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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: PTGR1 (ImmuneEditome ID:22949)

1. Gene summary of enriched editing regions for PTGR1

check button Gene summary
Gene informationGene symbol

PTGR1

Gene ID

22949

GeneSynonymsDIG-1|LTB4DH|PGR1|ZADH3
GeneCytomap

9q31.3

GeneTypeprotein-coding
GeneDescriptionprostaglandin reductase 1|15-oxoprostaglandin 13-reductase|D3T-inducible gene 1 protein|NAD(P)H-dependent alkenal/one oxidoreductase|NADP-dependent leukotriene B4 12-hydroxydehydrogenase|PRG-1|dithiolethione-inducible gene 1 protein|leukotriene B4 12-hydroxydehydrogenase|zinc binding alcohol dehydrogenase domain containing 3
GeneModificationdate20230329
UniprotIDQ14914;F6XGT7;Q5JVP2;F2Z3J9
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr9:111589787-111591686:-ENST00000309195.8ENSG00000106853.15PTGR1intronicAluSz6,L1M5,AluSz,AluSx1,AluSpchr9:111589787-111591686:-.alignment
chr9:111589787-111591686:-ENST00000374324.4ENSG00000106853.15PTGR1intronicAluSz6,L1M5,AluSz,AluSx1,AluSpchr9:111589787-111591686:-.alignment
chr9:111589787-111591686:-ENST00000407693.5ENSG00000106853.15PTGR1intronicAluSz6,L1M5,AluSz,AluSx1,AluSpchr9:111589787-111591686:-.alignment
chr9:111589787-111591686:-ENST00000422125.1ENSG00000106853.15PTGR1intronicAluSz6,L1M5,AluSz,AluSx1,AluSpchr9:111589787-111591686:-.alignment
chr9:111589787-111591686:-ENST00000538962.4ENSG00000106853.15PTGR1intronicAluSz6,L1M5,AluSz,AluSx1,AluSpchr9:111589787-111591686:-.alignment
chr9:111594574-111595155:-ENST00000374308.1ENSG00000106853.15PTGR1ncRNA_intronicAluY,AluSx1chr9:111594574-111595155:-.alignment
chr9:111594574-111595155:-ENST00000374313.4ENSG00000106853.15PTGR1ncRNA_intronicAluY,AluSx1chr9:111594574-111595155:-.alignment
chr9:111594574-111595155:-ENST00000485319.1ENSG00000106853.15PTGR1ncRNA_intronicAluY,AluSx1chr9:111594574-111595155:-.alignment
chr9:111596341-111596698:-ENST00000374308.1ENSG00000106853.15PTGR1ncRNA_intronicAluSx1,AluSxchr9:111596341-111596698:-.alignment
chr9:111596341-111596698:-ENST00000374313.4ENSG00000106853.15PTGR1ncRNA_intronicAluSx1,AluSxchr9:111596341-111596698:-.alignment
chr9:111596341-111596698:-ENST00000485319.1ENSG00000106853.15PTGR1ncRNA_intronicAluSx1,AluSxchr9:111596341-111596698:-.alignment


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2. Tumor-specific enriched editing regions for PTGR1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr9:111589787-111591686:-KICHEER9.2616e-04image
ENSG00000106853.15,PTGR1KICHEAG9.2616e-04image
chr9:111589787-111591686:-KIRCEER4.3736e-02image
chr9:111589787-111591686:-KIRPEER7.9535e-04image
ENSG00000106853.15,PTGR1KIRPEAG7.8728e-04image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000106853.15,PTGR1BLCAPathEAG4.8579e-029.7919e-030.2241image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for PTGR1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr9:111589787-111591686:-KICHEERENSG00000132199,ENOSF10.61264.3887e-022.0450e-030.4431imageNNNAMacrophages_M1GSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
chr9:111589787-111591686:-KICHEERENSG00000132199,ENOSF10.61264.3887e-022.0450e-030.4431imageNNNAMacrophages_M1GSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
chr9:111589787-111591686:-KICHEERENSG00000132199,ENOSF10.61264.3887e-022.0450e-030.4431imageNNNAMacrophages_M1GSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
chr9:111589787-111591686:-KICHEERENSG00000132199,ENOSF10.61264.3887e-022.0450e-030.4431imageNNNAMacrophages_M1GSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
chr9:111589787-111591686:-KICHEERENSG00000132199,ENOSF10.61264.3887e-022.0450e-030.4431imageNNNAMacrophages_M1GSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS

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4. Enriched editing regions and immune related splicing for PTGR1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for PTGR1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr9:111589787-111591686:-ACCEERB_cells_naive7.9958e-030.4086image
ENSG00000106853.15,PTGR1ACCEAGB_cells_naive7.9958e-030.4086image
chr9:111589787-111591686:-BLCAEERT_cells_regulatory_(Tregs)3.2890e-02-0.1866image
ENSG00000106853.15,PTGR1BLCAEAGT_cells_regulatory_(Tregs)3.2665e-02-0.1868image
chr9:111589787-111591686:-BRCAEERDendritic_cells_resting4.1964e-020.1348image
ENSG00000106853.15,PTGR1BRCAEAGDendritic_cells_resting4.3916e-020.1336image
chr9:111589787-111591686:-CESCEERMonocytes2.3995e-030.4841image
ENSG00000106853.15,PTGR1CESCEAGMonocytes2.3944e-030.4842image
chr9:111589787-111591686:-ESCAEERB_cells_naive8.6233e-030.2504image
chr9:111594574-111595155:-ESCAEERMonocytes2.2986e-02-0.4209image
ENSG00000106853.15,PTGR1ESCAEAGB_cells_naive7.4396e-030.2550image
chr9:111589787-111591686:-GBMEERNeutrophils1.4685e-020.2205image
ENSG00000106853.15,PTGR1GBMEAGNeutrophils1.4685e-020.2205image
chr9:111589787-111591686:-HNSCEERT_cells_CD4_memory_resting2.0320e-030.3485image
ENSG00000106853.15,PTGR1HNSCEAGT_cells_CD4_memory_resting2.0320e-030.3485image
chr9:111589787-111591686:-KICHEEREosinophils4.3280e-020.2994image
ENSG00000106853.15,PTGR1KICHEAGEosinophils4.3280e-020.2994image
ENSG00000106853.15,PTGR1LGGEAGNeutrophils3.7665e-020.2421image
chr9:111589787-111591686:-LIHCEERMacrophages_M13.0676e-020.1393image
ENSG00000106853.15,PTGR1LIHCEAGMacrophages_M13.0404e-020.1395image
chr9:111589787-111591686:-LUSCEERPlasma_cells3.5190e-02-0.1479image
ENSG00000106853.15,PTGR1LUSCEAGPlasma_cells3.9398e-02-0.1447image
chr9:111589787-111591686:-OVEERT_cells_follicular_helper1.5584e-02-0.1805image
ENSG00000106853.15,PTGR1OVEAGT_cells_follicular_helper1.6920e-02-0.1783image
ENSG00000106853.15,PTGR1SARCEAGT_cells_follicular_helper2.5903e-02-0.3874image
chr9:111589787-111591686:-STADEERT_cells_CD4_naive3.7623e-020.1522image
ENSG00000106853.15,PTGR1STADEAGT_cells_CD4_naive3.2347e-020.1558image
chr9:111589787-111591686:-THCAEERNK_cells_activated6.7261e-03-0.3381image
ENSG00000106853.15,PTGR1THCAEAGNK_cells_activated6.7261e-03-0.3381image


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6. Enriched editing regions and immune gene sets for PTGR1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000106853.15,PTGR1BLCAGSVA_HALLMARK_HYPOXIAEAG1.2922e-030.2782image
chr9:111589787-111591686:-BLCAGSVA_HALLMARK_HYPOXIAEER1.5587e-030.2737image
chr9:111589787-111591686:-BRCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER5.4965e-040.2271image
ENSG00000106853.15,PTGR1BRCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG5.5517e-040.2269image
chr9:111594574-111595155:-ESCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.8123e-020.3701image
chr9:111589787-111591686:-ESCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.4661e-03-0.3011image
ENSG00000106853.15,PTGR1ESCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG8.8433e-04-0.3140image
chr9:111589787-111591686:-HNSCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.2884e-02-0.2608image
ENSG00000106853.15,PTGR1HNSCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.2884e-02-0.2608image
ENSG00000106853.15,PTGR1KICHGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG4.0876e-020.3027image
chr9:111589787-111591686:-KICHGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER4.0876e-020.3027image
ENSG00000106853.15,PTGR1KIRCGSVA_HALLMARK_ADIPOGENESISEAG5.0385e-03-0.2644image
chr9:111589787-111591686:-KIRCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.0488e-02-0.2431image
ENSG00000106853.15,PTGR1LGGGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.1597e-02-0.2920image
ENSG00000106853.15,PTGR1LIHCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.7542e-02-0.1529image
chr9:111589787-111591686:-LIHCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.7742e-02-0.1526image
chr9:111589787-111591686:-LUADGSVA_HALLMARK_MYC_TARGETS_V1EER1.0045e-02-0.2731image
ENSG00000106853.15,PTGR1LUADGSVA_HALLMARK_MYC_TARGETS_V1EAG9.1879e-03-0.2762image
ENSG00000106853.15,PTGR1LUSCGSVA_HALLMARK_G2M_CHECKPOINTEAG4.8798e-030.1968image
chr9:111589787-111591686:-LUSCGSVA_HALLMARK_G2M_CHECKPOINTEER6.7801e-030.1895image
chr9:111589787-111591686:-OVGSVA_HALLMARK_ADIPOGENESISEER1.0047e-020.1920image
ENSG00000106853.15,PTGR1OVGSVA_HALLMARK_ADIPOGENESISEAG1.0145e-020.1917image
chr9:111589787-111591686:-PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.0901e-020.2532image
ENSG00000106853.15,PTGR1PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.0901e-020.2532image
ENSG00000106853.15,PTGR1PRADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG3.0110e-040.1921image
chr9:111589787-111591686:-PRADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER3.0162e-040.1921image
ENSG00000106853.15,PTGR1SARCGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG1.8043e-020.4092image
ENSG00000106853.15,PTGR1SKCMGSVA_HALLMARK_APICAL_SURFACEEAG9.5332e-030.2496image
chr9:111589787-111591686:-SKCMGSVA_HALLMARK_APICAL_SURFACEEER9.5332e-030.2496image
chr9:111589787-111591686:-STADGSVA_HALLMARK_ANGIOGENESISEER2.1616e-02-0.1679image
ENSG00000106853.15,PTGR1STADGSVA_HALLMARK_HYPOXIAEAG4.4197e-02-0.1465image
chr9:111589787-111591686:-TGCTGSVA_HALLMARK_HEME_METABOLISMEER4.2573e-02-0.3665image
ENSG00000106853.15,PTGR1TGCTGSVA_HALLMARK_HEME_METABOLISMEAG4.2573e-02-0.3665image
ENSG00000106853.15,PTGR1THCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG4.6150e-02-0.2522image
chr9:111589787-111591686:-THCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER4.6150e-02-0.2522image
chr9:111589787-111591686:-UCECGSVA_HALLMARK_DNA_REPAIREER2.6698e-02-0.3073image
ENSG00000106853.15,PTGR1UCECGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.3862e-02-0.3101image


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7. Enriched editing regions and drugs for PTGR1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000106853.15,PTGR1BLCAEHT.1864EAG2.6325e-020.1941image
chr9:111589787-111591686:-BLCAEHT.1864EER2.5615e-020.1950image
ENSG00000106853.15,PTGR1BRCABIRB.0796EAG1.3963e-020.1626image
chr9:111589787-111591686:-BRCABIRB.0796EER1.5515e-020.1601image
ENSG00000106853.15,PTGR1CESCMG.132EAG4.2896e-020.3347image
chr9:111589787-111591686:-CESCMG.132EER4.2987e-020.3345image
chr9:111594574-111595155:-ESCAATRAEER8.7071e-040.5844image
chr9:111589787-111591686:-ESCAElesclomolEER3.5615e-020.2015image
ENSG00000106853.15,PTGR1ESCAElesclomolEAG1.9178e-020.2240image
chr9:111589787-111591686:-GBMBleomycinEER9.2931e-03-0.2346image
ENSG00000106853.15,PTGR1GBMBleomycinEAG9.2931e-03-0.2346image
chr9:111589787-111591686:-HNSCBI.2536EER3.1083e-03-0.3349image
ENSG00000106853.15,PTGR1HNSCBI.2536EAG3.1083e-03-0.3349image
ENSG00000106853.15,PTGR1KICHBI.D1870EAG2.4868e-020.3305image
chr9:111589787-111591686:-KICHBI.D1870EER2.4868e-020.3305image
ENSG00000106853.15,PTGR1KIRCKIN001.135EAG1.0962e-020.2406image
chr9:111589787-111591686:-KIRCKIN001.135EER1.0012e-020.2446image
ENSG00000106853.15,PTGR1KIRPDocetaxelEAG4.5785e-020.2135image
chr9:111589787-111591686:-KIRPDocetaxelEER4.5439e-020.2138image
ENSG00000106853.15,PTGR1LGGBAY.61.3606EAG1.9104e-03-0.3550image
ENSG00000106853.15,PTGR1LIHCCEP.701EAG8.9348e-030.1681image
chr9:111589787-111591686:-LIHCCEP.701EER9.0540e-030.1678image
chr9:111589787-111591686:-LUADFH535EER2.0368e-020.2470image
ENSG00000106853.15,PTGR1LUADEpothilone.BEAG2.0032e-020.2476image
ENSG00000106853.15,PTGR1LUSCMetforminEAG2.6280e-03-0.2101image
chr9:111589787-111591686:-LUSCMetforminEER3.4532e-03-0.2043image
chr9:111589787-111591686:-OVCGP.60474EER7.6189e-04-0.2494image
ENSG00000106853.15,PTGR1OVA.443654EAG5.9783e-04-0.2541image
chr9:111589787-111591686:-PRADGSK269962AEER2.1148e-06-0.2503image
ENSG00000106853.15,PTGR1PRADGSK269962AEAG2.1151e-06-0.2503image
ENSG00000106853.15,PTGR1SARCJNJ.26854165EAG1.8044e-02-0.4092image
ENSG00000106853.15,PTGR1SKCMBI.2536EAG1.3989e-020.2370image
chr9:111589787-111591686:-SKCMBI.2536EER1.3989e-020.2370image
chr9:111589787-111591686:-STADBIBW2992EER2.3397e-03-0.2242image
ENSG00000106853.15,PTGR1STADBIBW2992EAG1.7218e-03-0.2295image
chr9:111589787-111591686:-TGCTAZD6482EER2.4051e-020.4044image
ENSG00000106853.15,PTGR1TGCTAZD6482EAG2.4051e-020.4044image
chr9:111589787-111591686:-THCAAxitinibEER2.5915e-020.2806image
ENSG00000106853.15,PTGR1THCAAxitinibEAG2.5915e-020.2806image
chr9:111589787-111591686:-UCECFH535EER1.4770e-020.3364image
ENSG00000106853.15,PTGR1UCECFH535EAG5.2654e-030.3780image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType