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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ATG14 (ImmuneEditome ID:22863)

1. Gene summary of enriched editing regions for ATG14

check button Gene summary
Gene informationGene symbol

ATG14

Gene ID

22863

GeneSynonymsATG14L|BARKOR|KIAA0831
GeneCytomap

14q22.3

GeneTypeprotein-coding
GeneDescriptionbeclin 1-associated autophagy-related key regulator|ATG14 autophagy related 14 homolog|Beclin 1-Interacting protein|autophagy-related protein 14-like protein
GeneModificationdate20230329
UniprotIDQ6ZNE5
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr14:55367451-55368542:-ENST00000558189.1ENSG00000126775.8ATG14ncRNA_exonicAluSq2,AluSx1chr14:55367451-55368542:-.alignment
chr14:55393551-55394326:-ENST00000247178.5ENSG00000126775.8ATG14intronicAluJb,L1ME3G,AluSgchr14:55393551-55394326:-.alignment


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2. Tumor-specific enriched editing regions for ATG14


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr14:55367451-55368542:-BRCAEER2.9045e-30image
ENSG00000126775.8,ATG14BRCAEAG8.6099e-30image
chr14:55367451-55368542:-COADEER4.6543e-05image
ENSG00000126775.8,ATG14COADEAG2.4933e-05image
chr14:55367451-55368542:-HNSCEER9.1773e-08image
ENSG00000126775.8,ATG14HNSCEAG9.3473e-08image
chr14:55367451-55368542:-KICHEER1.3528e-04image
ENSG00000126775.8,ATG14KICHEAG1.3528e-04image
chr14:55367451-55368542:-KIRCEER3.5785e-02image
ENSG00000126775.8,ATG14KIRCEAG3.6840e-02image
chr14:55367451-55368542:-KIRPEER3.3307e-04image
ENSG00000126775.8,ATG14KIRPEAG3.3307e-04image
chr14:55367451-55368542:-LUADEER1.0019e-02image
ENSG00000126775.8,ATG14LUADEAG2.0119e-03image
chr14:55367451-55368542:-LUSCEER6.5054e-05image
ENSG00000126775.8,ATG14LUSCEAG9.1233e-05image
chr14:55367451-55368542:-PRADEER3.2844e-07image
ENSG00000126775.8,ATG14PRADEAG3.6722e-07image
chr14:55367451-55368542:-THCAEER3.9947e-19image
ENSG00000126775.8,ATG14THCAEAG3.9685e-19image
chr14:55367451-55368542:-UCECEER4.3654e-08image
ENSG00000126775.8,ATG14UCECEAG4.0844e-08image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr14:55367451-55368542:-KIRCPathEER2.7918e-043.5552e-050.1813image
ENSG00000126775.8,ATG14KIRCPathEAG1.8177e-042.3925e-050.1852image
chr14:55367451-55368542:-LUADPathEER1.1351e-022.7472e-030.1352image
ENSG00000126775.8,ATG14LUADPathEAG2.1817e-025.0198e-030.1262image
chr14:55367451-55368542:-THCAPathEER2.3390e-046.7782e-050.1786image
ENSG00000126775.8,ATG14THCAPathEAG2.3294e-046.7628e-050.1786image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr14:55367451-55368542:-LGGEER1.2829e-035.0227e-068.6021e+03image
ENSG00000126775.8,ATG14LGGEAG1.2829e-038.2787e-067.1659e+03image

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3. Enriched editing regions and immune related genes for ATG14


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr14:55367451-55368542:-CESCEERENSG00000143774,GUK10.36881.7035e-073.0945e-130.4134imageNACIN1;ELAVL1;FAM120A;FUS;GTF2F1;NOP58;PCBP2;TARDBP;TROVE2;U2AF2NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr14:55367451-55368542:-KICHEERENSG00000169439,SDC2-0.69423.0452e-032.8253e-07-0.5904imageNACIN1;ELAVL1;FAM120A;FUS;GTF2F1;NOP58;PCBP2;TARDBP;TROVE2;U2AF2NAMonocytesGSVA_HALLMARK_SPERMATOGENESIS
chr14:55367451-55368542:-KICHEERENSG00000147606,SLC26A7-0.69983.0452e-033.8384e-04-0.4305imageNACIN1;ELAVL1;FUS;NOP58;TARDBP;TROVE2;U2AF2NAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr14:55367451-55368542:-KICHEERENSG00000163257,DCAF16-0.64281.2131e-027.7185e-06-0.5269imageNACIN1;ELAVL1;FAM120A;FUS;GTF2F1;NOP58;PCBP2;TARDBP;TROVE2;U2AF2NADendritic_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr14:55367451-55368542:-KICHEERENSG00000266472,MRPS210.63711.4387e-029.1224e-100.6756imageNACIN1;ELAVL1;FAM120A;FUS;GTF2F1;NOP58;PCBP2;TARDBP;TROVE2;U2AF2NAT_cells_CD4_memory_activatedGSVA_HALLMARK_ANDROGEN_RESPONSE
chr14:55367451-55368542:-KICHEERENSG00000047662,FAM184B-0.62191.7174e-026.3658e-05-0.4784imageNELAVL1;FUS;NOP58;TARDBP;TROVE2;U2AF2NAGSVA_HALLMARK_PROTEIN_SECRETION
chr14:55367451-55368542:-KICHEERENSG00000267265,CTC-550B14.7-0.62861.7174e-027.8226e-07-0.5722imageNELAVL1;FUS;NOP58;TARDBP;TROVE2;U2AF2NAT_cells_CD4_memory_activatedGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
chr14:55367451-55368542:-KICHEERENSG00000172164,SNTB1-0.61631.7174e-023.8426e-04-0.4305imageNACIN1;ELAVL1;FAM120A;FUS;NOP58;PCBP2;TARDBP;U2AF2NADendritic_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr14:55367451-55368542:-KICHEERENSG00000139433,GLTP-0.62321.7277e-022.2736e-07-0.5941imageNELAVL1;FAM120A;FUS;GTF2F1;NOP58;PCBP2;TARDBP;TROVE2;U2AF2NAMonocytesGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
chr14:55367451-55368542:-KICHEERENSG00000279041,CTD-2373N4.3-0.62141.7536e-022.8650e-05-0.4977imageNFUS;TARDBPNAMonocytesGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS

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4. Enriched editing regions and immune related splicing for ATG14


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000126775.8,ATG14
COADEAGIRENSG00000100918.8chr1424178605:24179906:24180009:24180035-0.27773.8336e-047.8254e-09-0.4035imageNAIFM1;AUH;BUD13;CSTF2T;DDX54;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LIN28B;MOV10;NOP58;PCBP2;PRPF8;RBFOX2;RBM10;RBM22;SF3A3;SF3B4;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;XRN2;ZNF184NAPlasma_cellsGSVA_HALLMARK_COMPLEMENT
ENSG00000126775.8,ATG14
COADEAGA5ENSG00000131236.12chr140059333:40059458:40040719:40040801:40040719:40040783-0.23094.0923e-025.3931e-11-0.4017imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;RBM5;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZNF184CAP1EosinophilsGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
ENSG00000126775.8,ATG14
ESCAEAGIRENSG00000170291.10chr177254582:7254803:7258587:7258639-0.26054.6073e-022.5419e-06-0.4192imageNAIFM1;AUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr14:55367451-55368542:-
ESCAEERIRENSG00000170291.10chr177254582:7254803:7258587:7258639-0.25983.9764e-023.4146e-06-0.4143imageNELAVL1;FAM120A;FUS;GTF2F1;NOP58;PCBP2;TARDBP;TROVE2;U2AF2NAT_cells_CD4_memory_restingGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr14:55367451-55368542:-
KICHEERESENSG00000204469.8chr631636535:31636608:31636732:31636950:31637041:316371360.45402.7829e-022.5055e-060.6317imageNACIN1;ELAVL1;FAM120A;FUS;GTF2F1;NOP58;PCBP2;TARDBP;TROVE2;U2AF2PRRC2ADendritic_cells_activatedGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000126775.8,ATG14
KICHEAGESENSG00000204469.8chr631636535:31636608:31636732:31636950:31637041:316371360.45403.7901e-022.5055e-060.6317imageNACIN1;AIFM1;ALYREF;AUH;BUD13;CELF2;CPSF6;CSTF2T;DDX3X;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;RANGAP1;RBFOX2;RBM22;RBM47;RBM5;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZNF184PRRC2ADendritic_cells_activatedGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000126775.8,ATG14
KIRCEAGIRENSG00000072818.7chr177350389:7350999:7351294:7351476-0.36832.9682e-111.6054e-15-0.4009imageNCSTF2T;DDX3X;DGCR8;DKC1;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPL;HNRNPU;KHSRP;LIN28B;LSM11;MSI2;PRPF8;RBFOX2;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;TAF15;TRA2A;U2AF1;U2AF2;ZNF184ACAP1T_cells_regulatory_(Tregs)GSVA_HALLMARK_ALLOGRAFT_REJECTION
chr14:55367451-55368542:-
OVEERIRENSG00000158062.16chr126284361:26284482:26285463:26285541-0.44017.8685e-103.2011e-13-0.4179imageNACIN1;ELAVL1;FAM120A;FUS;GTF2F1;NOP58;PCBP2;TARDBP;TROVE2;U2AF2NAB_cells_naiveGSVA_HALLMARK_PANCREAS_BETA_CELLS
chr14:55367451-55368542:-
OVEERIRENSG00000120963.7chr8101202332:101202447:101204649:101204693-0.33358.8692e-084.3942e-13-0.4798imageNELAVL1;FAM120A;FUS;GTF2F1;NOP58;PCBP2;TARDBP;TROVE2;U2AF2NAMacrophages_M1GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr14:55367451-55368542:-
OVEERIRENSG00000101473.12chr2045843526:45843772:45844262:45844420-0.34322.0791e-062.1924e-11-0.4010imageNELAVL1;FAM120A;FUS;GTF2F1;NOP58;PCBP2;TARDBP;U2AF2NAB_cells_memoryGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION

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5. Enriched editing regions and immune infiltration for ATG14


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr14:55367451-55368542:-BLCAEERT_cells_CD4_memory_activated3.3655e-070.2588image
ENSG00000126775.8,ATG14BLCAEAGT_cells_CD4_memory_activated3.0784e-070.2596image
chr14:55367451-55368542:-BRCAEERT_cells_CD4_memory_activated1.4350e-090.1853image
ENSG00000126775.8,ATG14BRCAEAGT_cells_CD4_memory_activated2.9848e-090.1814image
chr14:55367451-55368542:-CESCEERNeutrophils7.4388e-030.1580image
ENSG00000126775.8,ATG14CESCEAGNeutrophils7.5278e-030.1577image
chr14:55367451-55368542:-COADEERMacrophages_M11.0208e-030.2074image
ENSG00000126775.8,ATG14COADEAGT_cells_follicular_helper1.3816e-020.1558image
chr14:55367451-55368542:-ESCAEERMacrophages_M23.0404e-040.2837image
ENSG00000126775.8,ATG14ESCAEAGMacrophages_M22.9900e-040.2840image
chr14:55367451-55368542:-GBMEERMacrophages_M01.9703e-03-0.2436image
ENSG00000126775.8,ATG14GBMEAGMacrophages_M02.1205e-03-0.2420image
chr14:55367451-55368542:-HNSCEERMacrophages_M12.2227e-030.1406image
ENSG00000126775.8,ATG14HNSCEAGMacrophages_M12.0892e-030.1414image
chr14:55367451-55368542:-KICHEERT_cells_CD4_memory_activated1.5552e-030.3876image
ENSG00000126775.8,ATG14KICHEAGT_cells_CD4_memory_activated1.5552e-030.3876image
chr14:55367451-55368542:-KIRCEERT_cells_CD86.0654e-050.2064image
ENSG00000126775.8,ATG14KIRCEAGT_cells_CD86.4003e-050.2057image
chr14:55367451-55368542:-KIRPEERT_cells_CD4_memory_resting3.3237e-06-0.2772image
ENSG00000126775.8,ATG14KIRPEAGT_cells_CD4_memory_resting3.3237e-06-0.2772image
ENSG00000126775.8,ATG14LAMLEAGNK_cells_activated4.6982e-020.2400image
chr14:55367451-55368542:-LGGEERMacrophages_M13.8681e-030.1260image
ENSG00000126775.8,ATG14LGGEAGMacrophages_M13.7662e-030.1264image
chr14:55367451-55368542:-LUADEERT_cells_CD4_memory_activated5.6436e-030.1250image
ENSG00000126775.8,ATG14LUADEAGT_cells_CD4_memory_activated8.3608e-030.1186image
chr14:55367451-55368542:-LUSCEERT_cells_CD4_memory_activated3.0006e-080.2471image
ENSG00000126775.8,ATG14LUSCEAGT_cells_CD4_memory_activated3.2888e-080.2464image
chr14:55367451-55368542:-MESOEERMast_cells_resting3.9612e-03-0.3247image
ENSG00000126775.8,ATG14MESOEAGMast_cells_resting3.9612e-03-0.3247image
chr14:55367451-55368542:-OVEERT_cells_gamma_delta1.0542e-020.1529image
ENSG00000126775.8,ATG14OVEAGT_cells_gamma_delta1.6471e-020.1432image
chr14:55367451-55368542:-PAADEERNK_cells_resting2.2975e-020.1749image
ENSG00000126775.8,ATG14PAADEAGNK_cells_resting2.3002e-020.1748image
chr14:55367451-55368542:-PCPGEEREosinophils5.0550e-030.2173image
ENSG00000126775.8,ATG14PCPGEAGEosinophils5.1365e-030.2169image
chr14:55367451-55368542:-PRADEERB_cells_naive3.4001e-02-0.0971image
ENSG00000126775.8,ATG14PRADEAGB_cells_naive3.3758e-02-0.0972image
chr14:55367451-55368542:-SARCEERNK_cells_resting4.4822e-03-0.1856image
ENSG00000126775.8,ATG14SARCEAGNK_cells_resting4.4604e-03-0.1857image
chr14:55367451-55368542:-SKCMEERT_cells_regulatory_(Tregs)8.6836e-040.1568image
ENSG00000126775.8,ATG14SKCMEAGT_cells_regulatory_(Tregs)9.5008e-040.1556image
chr14:55367451-55368542:-STADEERT_cells_CD4_memory_resting8.2187e-04-0.1957image
ENSG00000126775.8,ATG14STADEAGT_cells_CD4_memory_resting1.5238e-03-0.1853image
chr14:55367451-55368542:-TGCTEERMacrophages_M27.7569e-05-0.3159image
ENSG00000126775.8,ATG14TGCTEAGMacrophages_M28.1208e-05-0.3151image
chr14:55367451-55368542:-THCAEERT_cells_regulatory_(Tregs)1.0223e-060.2180image
ENSG00000126775.8,ATG14THCAEAGT_cells_regulatory_(Tregs)9.9896e-070.2182image
chr14:55367451-55368542:-THYMEERT_cells_CD4_memory_activated2.5634e-020.2232image
ENSG00000126775.8,ATG14THYMEAGT_cells_CD4_memory_activated2.5634e-020.2232image
chr14:55367451-55368542:-UCECEERMacrophages_M12.7226e-020.1803image
ENSG00000126775.8,ATG14UCECEAGMacrophages_M12.7586e-020.1793image
chr14:55367451-55368542:-UCSEERB_cells_naive1.9099e-02-0.3152image
ENSG00000126775.8,ATG14UCSEAGB_cells_naive1.9099e-02-0.3152image
chr14:55367451-55368542:-UVMEERNK_cells_resting2.2717e-02-0.2740image
ENSG00000126775.8,ATG14UVMEAGNK_cells_resting2.2447e-02-0.2745image


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6. Enriched editing regions and immune gene sets for ATG14


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr14:55367451-55368542:-KIRPEER2.1391e-02image2.3660e-030.1833image
ENSG00000126775.8,ATG14KIRPEAG2.1391e-02image2.3660e-030.1833image
chr14:55367451-55368542:-LUSCEER4.0416e-02image4.1009e-020.0924image
ENSG00000126775.8,ATG14LUSCEAG4.1957e-02image4.3331e-020.0913image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr14:55367451-55368542:-BLCAEER1.5581e-030.16222.1841e-020.11798.6345e-030.13495.0541e-100.3128image
ENSG00000126775.8,ATG14BLCAEAG1.5156e-030.16262.2797e-020.11718.4216e-030.13534.1584e-100.3142image
chr14:55367451-55368542:-BRCAEER3.8163e-150.23933.7388e-100.19188.1274e-060.13722.1641e-040.1139image
ENSG00000126775.8,ATG14BRCAEAG1.7933e-140.23311.0263e-090.18662.0799e-050.13075.2773e-040.1066image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000126775.8,ATG14ACCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.5046e-020.2981image
chr14:55367451-55368542:-ACCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.5046e-020.2981image
ENSG00000126775.8,ATG14BLCAGSVA_HALLMARK_COMPLEMENTEAG5.4276e-140.3740image
chr14:55367451-55368542:-BLCAGSVA_HALLMARK_COMPLEMENTEER5.6638e-140.3737image
chr14:55367451-55368542:-BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.0727e-250.3155image
ENSG00000126775.8,ATG14BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.0097e-230.3024image
chr14:55367451-55368542:-CESCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.4688e-070.3047image
ENSG00000126775.8,ATG14CESCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.3662e-070.3055image
ENSG00000126775.8,ATG14CHOLGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG1.4304e-020.4164image
chr14:55367451-55368542:-CHOLGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.4304e-020.4164image
ENSG00000126775.8,ATG14COADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG4.2647e-050.2563image
chr14:55367451-55368542:-COADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.3571e-060.2945image
ENSG00000126775.8,ATG14DLBCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG4.0776e-02-0.4119image
chr14:55393551-55394326:-ESCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER3.7330e-03-0.6173image
chr14:55367451-55368542:-ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER4.7392e-030.2236image
ENSG00000126775.8,ATG14ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG4.3964e-030.2255image
chr14:55367451-55368542:-GBMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER4.6116e-040.2746image
ENSG00000126775.8,ATG14GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG6.0991e-040.2689image
ENSG00000126775.8,ATG14HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.4482e-120.3095image
chr14:55367451-55368542:-HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.3258e-120.3097image
chr14:55367451-55368542:-KICHGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER2.5853e-02-0.2785image
ENSG00000126775.8,ATG14KICHGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG2.5853e-02-0.2785image
chr14:55367451-55368542:-KIRCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER4.0660e-100.3168image
ENSG00000126775.8,ATG14KIRCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.3226e-100.3251image
chr14:55367451-55368542:-KIRPGSVA_HALLMARK_COAGULATIONEER3.8800e-050.2463image
ENSG00000126775.8,ATG14KIRPGSVA_HALLMARK_COAGULATIONEAG3.8800e-050.2463image
ENSG00000126775.8,ATG14LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG6.9969e-030.3219image
ENSG00000126775.8,ATG14LGGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG6.5020e-11-0.2803image
chr14:55367451-55368542:-LGGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER4.7989e-11-0.2821image
chr14:55367451-55368542:-LIHCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER1.4340e-030.1963image
ENSG00000126775.8,ATG14LIHCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.4340e-030.1963image
ENSG00000126775.8,ATG14LUADGSVA_HALLMARK_PROTEIN_SECRETIONEAG7.9135e-080.2389image
chr14:55393551-55394326:-LUADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.0610e-020.3337image
chr14:55367451-55368542:-LUADGSVA_HALLMARK_PROTEIN_SECRETIONEER2.6708e-080.2482image
ENSG00000126775.8,ATG14LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.9146e-060.2068image
chr14:55367451-55368542:-LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.7834e-060.2071image
chr14:55367451-55368542:-MESOGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER1.2444e-020.2836image
ENSG00000126775.8,ATG14MESOGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.2444e-020.2836image
chr14:55367451-55368542:-OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.4677e-110.3898image
ENSG00000126775.8,ATG14OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.6718e-110.3882image
chr14:55367451-55368542:-PCPGGSVA_HALLMARK_KRAS_SIGNALING_DNEER3.8127e-040.2734image
ENSG00000126775.8,ATG14PCPGGSVA_HALLMARK_KRAS_SIGNALING_DNEAG3.9986e-040.2724image
ENSG00000126775.8,ATG14PRADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG2.5550e-06-0.2134image
chr14:55367451-55368542:-PRADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.3990e-06-0.2188image
ENSG00000126775.8,ATG14READGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.8931e-020.2231image
chr14:55367451-55368542:-READGSVA_HALLMARK_BILE_ACID_METABOLISMEER3.8931e-020.2231image
chr14:55367451-55368542:-SARCGSVA_HALLMARK_KRAS_SIGNALING_UPEER4.2209e-100.3946image
ENSG00000126775.8,ATG14SARCGSVA_HALLMARK_KRAS_SIGNALING_UPEAG4.2876e-100.3944image
chr14:55367451-55368542:-SKCMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.3042e-090.2775image
ENSG00000126775.8,ATG14SKCMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.3550e-090.2773image
ENSG00000126775.8,ATG14STADGSVA_HALLMARK_UV_RESPONSE_UPEAG8.5471e-050.2286image
chr14:55367451-55368542:-STADGSVA_HALLMARK_UV_RESPONSE_UPEER1.3097e-050.2533image
chr14:55367451-55368542:-TGCTGSVA_HALLMARK_TGF_BETA_SIGNALINGEER2.1073e-05-0.3386image
ENSG00000126775.8,ATG14TGCTGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG2.1920e-05-0.3380image
chr14:55367451-55368542:-THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER1.5603e-120.3112image
ENSG00000126775.8,ATG14THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.5615e-120.3112image
chr14:55367451-55368542:-THYMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.2048e-050.4106image
ENSG00000126775.8,ATG14THYMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.2048e-050.4106image
ENSG00000126775.8,ATG14UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.6410e-040.2710image
chr14:55367451-55368542:-UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.5371e-040.2722image
chr14:55367451-55368542:-UCSGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER7.4402e-040.4413image
ENSG00000126775.8,ATG14UCSGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG7.4402e-040.4413image
ENSG00000126775.8,ATG14UVMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG8.6445e-070.5523image
chr14:55367451-55368542:-UVMGSVA_HALLMARK_KRAS_SIGNALING_DNEER8.2794e-070.5531image


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7. Enriched editing regions and drugs for ATG14


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr14:55367451-55368542:-ACCAKT.inhibitor.VIIIEER1.7010e-040.4467image
ENSG00000126775.8,ATG14ACCAKT.inhibitor.VIIIEAG1.7010e-040.4467image
ENSG00000126775.8,ATG14BLCACMKEAG1.8332e-10-0.3203image
chr14:55367451-55368542:-BLCACMKEER1.7351e-10-0.3207image
chr14:55367451-55368542:-BRCACCT007093EER8.7339e-170.2529image
ENSG00000126775.8,ATG14BRCACCT007093EAG3.0101e-150.2398image
ENSG00000126775.8,ATG14CESCAZD.2281EAG6.0046e-07-0.2900image
chr14:55367451-55368542:-CESCAZD.2281EER6.3225e-07-0.2895image
ENSG00000126775.8,ATG14CHOLCMKEAG1.3295e-02-0.4204image
chr14:55367451-55368542:-CHOLCMKEER1.3295e-02-0.4204image
ENSG00000126775.8,ATG14COADJNJ.26854165EAG3.4120e-04-0.2252image
chr14:55367451-55368542:-COADCI.1040EER1.9855e-04-0.2342image
ENSG00000126775.8,ATG14DLBCAZ628EAG9.3636e-03-0.5090image
chr14:55393551-55394326:-ESCAJW.7.52.1EER4.3909e-03-0.6088image
ENSG00000126775.8,ATG14ESCAGSK269962AEAG1.2052e-05-0.3404image
chr14:55367451-55368542:-ESCAGSK269962AEER9.6264e-06-0.3440image
chr14:55367451-55368542:-GBMGSK.650394EER2.6089e-070.3948image
ENSG00000126775.8,ATG14GBMGSK.650394EAG3.8919e-070.3895image
ENSG00000126775.8,ATG14HNSCCI.1040EAG1.7054e-10-0.2887image
chr14:55367451-55368542:-HNSCCI.1040EER1.6144e-10-0.2891image
chr14:55367451-55368542:-KICHCisplatinEER2.1248e-12-0.7428image
ENSG00000126775.8,ATG14KICHCisplatinEAG2.1248e-12-0.7428image
chr14:55367451-55368542:-KIRCCisplatinEER2.5235e-09-0.3027image
ENSG00000126775.8,ATG14KIRCCI.1040EAG1.6242e-09-0.3062image
chr14:55367451-55368542:-KIRPBAY.61.3606EER4.9266e-070.2988image
ENSG00000126775.8,ATG14KIRPBAY.61.3606EAG4.9266e-070.2988image
ENSG00000126775.8,ATG14LAMLCisplatinEAG1.9236e-04-0.4343image
chr14:55367451-55368542:-LGGMG.132EER1.4889e-12-0.3026image
ENSG00000126775.8,ATG14LGGMG.132EAG2.2446e-12-0.3002image
ENSG00000126775.8,ATG14LIHCGSK.650394EAG2.6164e-030.1856image
chr14:55367451-55368542:-LIHCGSK.650394EER2.6164e-030.1856image
ENSG00000126775.8,ATG14LUADCisplatinEAG1.1876e-03-0.1456image
chr14:55367451-55368542:-LUADGemcitabineEER9.3899e-04-0.1492image
chr14:55393551-55394326:-LUADIPA.3EER2.9683e-020.3578image
ENSG00000126775.8,ATG14LUSCCEP.701EAG5.8497e-06-0.2031image
chr14:55367451-55368542:-LUSCCEP.701EER5.0168e-06-0.2045image
ENSG00000126775.8,ATG14MESODasatinibEAG5.8188e-05-0.4416image
chr14:55367451-55368542:-MESODasatinibEER5.8188e-05-0.4416image
chr14:55367451-55368542:-OVA.770041EER1.1179e-11-0.3919image
ENSG00000126775.8,ATG14OVDasatinibEAG8.4731e-12-0.3940image
ENSG00000126775.8,ATG14PAADAMG.706EAG6.8410e-03-0.2092image
chr14:55367451-55368542:-PAADAMG.706EER6.8843e-03-0.2090image
chr14:55367451-55368542:-PCPGBAY.61.3606EER1.0342e-040.2976image
ENSG00000126775.8,ATG14PCPGBAY.61.3606EAG1.1614e-040.2956image
ENSG00000126775.8,ATG14PRADBexaroteneEAG5.3280e-100.2794image
chr14:55367451-55368542:-PRADBexaroteneEER1.1874e-090.2738image
chr14:55367451-55368542:-READGSK.650394EER6.2301e-040.3617image
ENSG00000126775.8,ATG14READGSK.650394EAG6.2301e-040.3617image
chr14:55367451-55368542:-SARCAZD7762EER2.0554e-10-0.4010image
ENSG00000126775.8,ATG14SARCAZD7762EAG2.0734e-10-0.4009image
chr14:55367451-55368542:-SKCMGNF.2EER2.6249e-13-0.3363image
ENSG00000126775.8,ATG14SKCMGNF.2EAG2.5349e-13-0.3365image
chr14:55393551-55394326:-STADAZD6244EER3.9627e-02-0.3227image
chr14:55367451-55368542:-STADAZD.2281EER1.9990e-03-0.1814image
ENSG00000126775.8,ATG14STADAZD.2281EAG9.6585e-04-0.1931image
ENSG00000126775.8,ATG14TGCTBMS.754807EAG1.2933e-040.3065image
chr14:55367451-55368542:-TGCTBMS.754807EER1.1367e-040.3089image
ENSG00000126775.8,ATG14THCACI.1040EAG3.8588e-18-0.3775image
chr14:55367451-55368542:-THCACI.1040EER3.8033e-18-0.3775image
chr14:55367451-55368542:-THYMEmbelinEER2.9256e-070.4862image
ENSG00000126775.8,ATG14THYMEmbelinEAG2.9256e-070.4862image
chr14:55367451-55368542:-UCECFH535EER7.1547e-050.3184image
ENSG00000126775.8,ATG14UCECFH535EAG8.0154e-050.3154image
chr14:55367451-55368542:-UCSJNK.9LEER2.3211e-060.5883image
ENSG00000126775.8,ATG14UCSJNK.9LEAG2.3211e-060.5883image
ENSG00000126775.8,ATG14UVMGNF.2EAG6.6032e-06-0.5129image
chr14:55367451-55368542:-UVMGNF.2EER6.2136e-06-0.5142image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType