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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: AAK1 (ImmuneEditome ID:22848)

1. Gene summary of enriched editing regions for AAK1

check button Gene summary
Gene informationGene symbol

AAK1

Gene ID

22848

GeneSynonyms-
GeneCytomap

2p13.3

GeneTypeprotein-coding
GeneDescriptionAP2-associated protein kinase 1|adaptor-associated kinase 1
GeneModificationdate20230509
UniprotIDQ2M2I8;A0A096LP60;A0A096LNZ0;A0A096LP25;E9PG46
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr2:69459300-69459490:-ENST00000606389.4ENSG00000115977.17AAK1UTR3AluJbchr2:69459300-69459490:-.alignment
chr2:69461572-69463973:-ENST00000409068.4ENSG00000115977.17AAK1exonicL1PA3,AluSq2,AluSg,AluJr,AluSx3chr2:69461572-69463973:-.alignment
chr2:69503745-69504283:-ENST00000489327.1ENSG00000115977.17AAK1ncRNA_intronicAluSp,AluSzchr2:69503745-69504283:-.alignment
chr2:69511037-69511790:-ENST00000406297.6ENSG00000115977.17AAK1intronicNoRepeatchr2:69511037-69511790:-.alignment
chr2:69511037-69511790:-ENST00000409068.4ENSG00000115977.17AAK1intronicNoRepeatchr2:69511037-69511790:-.alignment
chr2:69511037-69511790:-ENST00000409085.7ENSG00000115977.17AAK1intronicNoRepeatchr2:69511037-69511790:-.alignment
chr2:69626579-69626821:-ENST00000495836.1ENSG00000115977.17AAK1ncRNA_intronicAluJbchr2:69626579-69626821:-.alignment


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2. Tumor-specific enriched editing regions for AAK1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr2:69461572-69463973:-COADEER2.9313e-02image
chr2:69461572-69463973:-KIRCEER1.7287e-04image
ENSG00000115977.17,AAK1KIRCEAG1.8574e-03image
chr2:69461572-69463973:-LUSCEER2.1076e-02image
ENSG00000115977.17,AAK1LUSCEAG2.1235e-02image
chr2:69461572-69463973:-THCAEER3.8710e-05image
ENSG00000115977.17,AAK1THCAEAG5.0311e-13image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000115977.17,AAK1KIRPCliEAG2.0523e-024.3901e-030.2464image
ENSG00000115977.17,AAK1SKCMPathEAG4.4150e-022.7044e-020.1351image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr2:69461572-69463973:-SKCMEER4.8335e-033.2754e-028.7567e+00image

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3. Enriched editing regions and immune related genes for AAK1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr2:69461572-69463973:-OVEERENSG00000164758,MED300.31201.5069e-041.9353e-130.4487imageNIGF2BP2;NOP56;UPF1NAT_cells_follicular_helperGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr2:69461572-69463973:-OVEERENSG00000173113,TRMT1120.31091.5257e-043.9686e-110.4073imageNIGF2BP2;NOP56;UPF1NAT_cells_CD8GSVA_HALLMARK_HEDGEHOG_SIGNALING
chr2:69461572-69463973:-OVEERENSG00000182117,NOP100.29923.1033e-041.5259e-110.4152imageNIGF2BP2;NOP56;UPF1NAT_cells_CD8GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr2:69461572-69463973:-OVEERENSG00000140264,SERF20.26391.5687e-032.9120e-110.4099imageNDHX9;IGF2BP2;NOP56;UPF1NANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr2:69461572-69463973:-OVEERENSG00000147654,EBAG90.22649.9481e-031.5206e-110.4152imageNDHX9;IGF2BP2;NOP56;UPF1EBAG9B_cells_naiveGSVA_HALLMARK_ADIPOGENESIS
chr2:69461572-69463973:-OVEERENSG00000169020,ATP5I0.22761.0150e-024.6241e-110.4060imageNIGF2BP2;NOP56;UPF1NANK_cells_activatedGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr2:69461572-69463973:-OVEERENSG00000279225,RP11-2K6.10.21351.8557e-022.5577e-120.4293imageNNNAT_cells_CD8GSVA_HALLMARK_MITOTIC_SPINDLE

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4. Enriched editing regions and immune related splicing for AAK1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000115977.17,AAK1
ESCAEAGESENSG00000105341.14chr1941433626:41433673:41438217:41438414:41439881:41439896-0.27779.0665e-031.2854e-07-0.4562imageNADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NANK_cells_activatedGSVA_HALLMARK_DNA_REPAIR
ENSG00000115977.17,AAK1
ESCAEAGESENSG00000145390.7chr4119212742:119212873:119214069:119214222:119217549:1192176730.32233.0576e-027.1242e-080.4214imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TROVE2;U2AF1;U2AF2;UPF1;WTAP;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000115977.17,AAK1
HNSCEAGMEXENSG00000153201.11chr2108772867:108773046:108775731:108775780:108777129:108777231:108781268:108781429-0.19671.5594e-021.0435e-15-0.4003imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
ENSG00000115977.17,AAK1
HNSCEAGA3ENSG00000115207.9chr227327176:27327258:27326292:27326723:27326292:273268930.18662.6792e-024.9179e-170.4169imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000115977.17,AAK1
HNSCEAGA5ENSG00000160271.10chr9133100263:133100382:133101519:133101582:133100495:133101582-0.18382.8420e-027.7678e-16-0.4019imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;MBNL2;METTL3;MOV10;MSI1;MSI2;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM5;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1;YWHAG;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_ANDROGEN_RESPONSE
ENSG00000115977.17,AAK1
HNSCEAGIRENSG00000175727.9chr12122132524:122133987:122135223:1221353450.27591.1720e-055.5290e-180.4304imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;WTAP;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
ENSG00000115977.17,AAK1
HNSCEAGMEXENSG00000063046.13chr1253034645:53034709:53037408:53037622:53039234:53039343:53039629:53039702-0.22662.6352e-031.6213e-18-0.4345imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;WTAP;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000115977.17,AAK1
HNSCEAGMEXENSG00000063046.13chr1253034645:53034709:53037408:53037622:53039237:53039343:53039629:53039702-0.22652.6367e-031.6147e-18-0.4345imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;WTAP;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000115977.17,AAK1
OVEAGIRENSG00000196670.9chr5180847614:180850784:180851380:180851493-0.16431.2947e-023.2097e-10-0.4094imageNADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RBM5;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAGSVA_HALLMARK_HEDGEHOG_SIGNALING
ENSG00000115977.17,AAK1
THCAEAGMEXENSG00000022840.11chr12120557545:120557682:120560725:120560886:120571190:120571291:120575630:120575688-0.24691.5711e-045.6530e-17-0.4002imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;WTAP;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NANK_cells_activatedGSVA_HALLMARK_HEME_METABOLISM

More results



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5. Enriched editing regions and immune infiltration for AAK1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr2:69461572-69463973:-ACCEERNK_cells_activated4.6154e-030.5689image
ENSG00000115977.17,AAK1ACCEAGB_cells_naive1.4487e-02-0.4652image
chr2:69461572-69463973:-BLCAEERMast_cells_resting1.7385e-020.1697image
ENSG00000115977.17,AAK1BLCAEAGMast_cells_resting2.2680e-020.1587image
ENSG00000115977.17,AAK1BRCAEAGT_cells_regulatory_(Tregs)9.9685e-030.0910image
chr2:69461572-69463973:-CESCEERDendritic_cells_activated2.0878e-020.1911image
ENSG00000115977.17,AAK1CESCEAGMonocytes4.4551e-020.1611image
chr2:69461572-69463973:-COADEERPlasma_cells1.9319e-02-0.2170image
ENSG00000115977.17,AAK1COADEAGMast_cells_activated3.4482e-020.1924image
chr2:69461572-69463973:-ESCAEERNeutrophils3.9942e-030.2278image
ENSG00000115977.17,AAK1ESCAEAGPlasma_cells1.2249e-040.2990image
chr2:69461572-69463973:-HNSCEERT_cells_CD4_memory_resting1.6026e-03-0.1642image
ENSG00000115977.17,AAK1HNSCEAGT_cells_CD4_memory_resting1.3547e-03-0.1658image
chr2:69461572-69463973:-KICHEERNK_cells_activated1.9706e-030.4356image
ENSG00000115977.17,AAK1KICHEAGNK_cells_activated1.9584e-030.4316image
chr2:69461572-69463973:-KIRCEERMacrophages_M22.2694e-03-0.1774image
ENSG00000115977.17,AAK1KIRCEAGDendritic_cells_resting1.0694e-02-0.1474image
chr2:69461572-69463973:-KIRPEERNK_cells_resting4.9800e-030.2004image
ENSG00000115977.17,AAK1KIRPEAGNK_cells_resting4.3133e-030.2020image
chr2:69461572-69463973:-LAMLEERT_cells_CD4_memory_resting3.6776e-030.2747image
ENSG00000115977.17,AAK1LAMLEAGT_cells_CD4_memory_resting3.8233e-020.1879image
chr2:69461572-69463973:-LGGEERMonocytes1.4434e-030.1580image
ENSG00000115977.17,AAK1LGGEAGMonocytes4.2286e-030.1402image
chr2:69461572-69463973:-LUADEERPlasma_cells1.0509e-020.1438image
ENSG00000115977.17,AAK1LUADEAGEosinophils9.1612e-03-0.1455image
chr2:69461572-69463973:-LUSCEERB_cells_memory9.2732e-040.1640image
ENSG00000115977.17,AAK1LUSCEAGB_cells_memory7.1199e-040.1673image
chr2:69461572-69463973:-MESOEERT_cells_CD4_memory_activated1.5591e-020.4058image
chr2:69461572-69463973:-OVEERT_cells_CD82.0342e-030.1970image
ENSG00000115977.17,AAK1OVEAGEosinophils2.5853e-02-0.1393image
chr2:69461572-69463973:-PAADEERT_cells_gamma_delta3.6594e-020.2093image
ENSG00000115977.17,AAK1PAADEAGT_cells_gamma_delta2.9170e-020.2150image
chr2:69461572-69463973:-PCPGEERB_cells_naive9.3422e-030.2726image
ENSG00000115977.17,AAK1PCPGEAGB_cells_naive3.2170e-020.2113image
chr2:69461572-69463973:-PRADEERT_cells_CD85.1512e-030.1434image
ENSG00000115977.17,AAK1PRADEAGMast_cells_activated2.4938e-02-0.1137image
chr2:69461572-69463973:-READEERB_cells_naive6.3965e-04-0.4897image
ENSG00000115977.17,AAK1READEAGB_cells_naive9.9905e-04-0.4742image
chr2:69461572-69463973:-SARCEERMacrophages_M01.3798e-02-0.2027image
chr2:69461572-69463973:-STADEERT_cells_follicular_helper2.9438e-020.1206image
chr2:69626579-69626821:-STADEERMacrophages_M22.9743e-020.4637image
ENSG00000115977.17,AAK1STADEAGT_cells_follicular_helper1.9537e-020.1248image
chr2:69461572-69463973:-TGCTEERNK_cells_resting1.9114e-02-0.4185image
ENSG00000115977.17,AAK1TGCTEAGNK_cells_resting1.9114e-02-0.4185image
chr2:69461572-69463973:-THCAEERT_cells_regulatory_(Tregs)3.8025e-020.1040image
ENSG00000115977.17,AAK1THCAEAGNK_cells_activated3.6801e-020.1039image
chr2:69461572-69463973:-THYMEERDendritic_cells_activated1.5340e-030.4208image
ENSG00000115977.17,AAK1THYMEAGMast_cells_activated3.7506e-030.3748image
ENSG00000115977.17,AAK1UCECEAGNK_cells_activated2.8894e-02-0.3334image


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6. Enriched editing regions and immune gene sets for AAK1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr2:69461572-69463973:-BLCAGSVA_HALLMARK_MITOTIC_SPINDLEEER2.1856e-02-0.1637image
ENSG00000115977.17,AAK1BLCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.7457e-03-0.2076image
chr2:69461572-69463973:-BRCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.2622e-110.2350image
ENSG00000115977.17,AAK1BRCAGSVA_HALLMARK_DNA_REPAIREAG3.1433e-060.1638image
ENSG00000115977.17,AAK1CESCGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.4781e-03-0.2406image
chr2:69461572-69463973:-CESCGSVA_HALLMARK_MITOTIC_SPINDLEEER3.1029e-03-0.2432image
ENSG00000115977.17,AAK1COADGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.5161e-02-0.2203image
chr2:69461572-69463973:-COADGSVA_HALLMARK_NOTCH_SIGNALINGEER4.8651e-03-0.2598image
chr2:69461572-69463973:-ESCAGSVA_HALLMARK_DNA_REPAIREER1.4744e-020.1937image
ENSG00000115977.17,AAK1ESCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.4965e-04-0.2792image
chr2:69461572-69463973:-GBMGSVA_HALLMARK_APICAL_JUNCTIONEER1.6586e-03-0.3076image
ENSG00000115977.17,AAK1GBMGSVA_HALLMARK_UV_RESPONSE_UPEAG1.4289e-02-0.2374image
chr2:69461572-69463973:-HNSCGSVA_HALLMARK_MITOTIC_SPINDLEEER3.0842e-06-0.2408image
ENSG00000115977.17,AAK1HNSCGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.7690e-06-0.2350image
ENSG00000115977.17,AAK1KICHGSVA_HALLMARK_MYC_TARGETS_V1EAG3.4122e-02-0.3033image
chr2:69461572-69463973:-KICHGSVA_HALLMARK_MITOTIC_SPINDLEEER3.4476e-03-0.4139image
chr2:69461572-69463973:-KIRCGSVA_HALLMARK_MITOTIC_SPINDLEEER2.3731e-04-0.2128image
ENSG00000115977.17,AAK1KIRCGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.1960e-02-0.1325image
ENSG00000115977.17,AAK1KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.4968e-03-0.2011image
chr2:69461572-69463973:-KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEER1.7934e-03-0.2222image
ENSG00000115977.17,AAK1LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG5.3546e-03-0.2507image
chr2:69461572-69463973:-LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.0399e-02-0.2434image
ENSG00000115977.17,AAK1LGGGSVA_HALLMARK_ANGIOGENESISEAG4.0648e-03-0.1408image
chr2:69461572-69463973:-LGGGSVA_HALLMARK_ANGIOGENESISEER2.6396e-03-0.1492image
ENSG00000115977.17,AAK1LIHCGSVA_HALLMARK_GLYCOLYSISEAG2.4783e-02-0.2741image
chr2:69461572-69463973:-LIHCGSVA_HALLMARK_HEME_METABOLISMEER2.8997e-02-0.2798image
ENSG00000115977.17,AAK1LUADGSVA_HALLMARK_ANGIOGENESISEAG1.5354e-040.2101image
chr2:69461572-69463973:-LUADGSVA_HALLMARK_ANGIOGENESISEER1.3654e-030.1794image
chr2:69461572-69463973:-LUSCGSVA_HALLMARK_UV_RESPONSE_DNEER5.1591e-06-0.2243image
ENSG00000115977.17,AAK1LUSCGSVA_HALLMARK_UV_RESPONSE_DNEAG6.9885e-06-0.2210image
ENSG00000115977.17,AAK1MESOGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.1287e-020.3774image
chr2:69461572-69463973:-MESOGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.5634e-030.4439image
ENSG00000115977.17,AAK1OVGSVA_HALLMARK_DNA_REPAIREAG1.4182e-030.1984image
chr2:69461572-69463973:-OVGSVA_HALLMARK_DNA_REPAIREER3.5833e-050.2618image
chr2:69461572-69463973:-PAADGSVA_HALLMARK_UV_RESPONSE_DNEER2.9839e-02-0.2174image
ENSG00000115977.17,AAK1PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.5989e-030.2771image
chr2:69461572-69463973:-PCPGGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER4.3366e-030.2980image
chr2:69461572-69463973:-PRADGSVA_HALLMARK_MITOTIC_SPINDLEEER1.3824e-08-0.2864image
ENSG00000115977.17,AAK1PRADGSVA_HALLMARK_MITOTIC_SPINDLEEAG6.9342e-09-0.2884image
chr2:69461572-69463973:-READGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.5028e-02-0.3003image
ENSG00000115977.17,AAK1READGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG3.5857e-02-0.3137image
chr2:69461572-69463973:-SARCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER8.9049e-040.2712image
ENSG00000115977.17,AAK1SARCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.0898e-02-0.2027image
chr2:69461572-69463973:-SKCMGSVA_HALLMARK_MITOTIC_SPINDLEEER4.8776e-03-0.1616image
ENSG00000115977.17,AAK1SKCMGSVA_HALLMARK_P53_PATHWAYEAG6.2718e-030.1552image
chr2:69461572-69463973:-STADGSVA_HALLMARK_DNA_REPAIREER2.3254e-040.2025image
ENSG00000115977.17,AAK1STADGSVA_HALLMARK_UV_RESPONSE_DNEAG3.0035e-09-0.3103image
ENSG00000115977.17,AAK1TGCTGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.7313e-02-0.4245image
chr2:69461572-69463973:-TGCTGSVA_HALLMARK_NOTCH_SIGNALINGEER1.7313e-02-0.4245image
chr2:69461572-69463973:-THCAGSVA_HALLMARK_UV_RESPONSE_DNEER6.6168e-04-0.1700image
ENSG00000115977.17,AAK1THCAGSVA_HALLMARK_UV_RESPONSE_DNEAG3.0299e-05-0.2059image
chr2:69461572-69463973:-THYMGSVA_HALLMARK_GLYCOLYSISEER5.8246e-040.4530image
ENSG00000115977.17,AAK1THYMGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG2.4276e-02-0.2956image
chr2:69461572-69463973:-UCECGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.2230e-020.4078image
ENSG00000115977.17,AAK1UCSGSVA_HALLMARK_UV_RESPONSE_DNEAG3.2552e-020.4569image


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7. Enriched editing regions and drugs for AAK1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000115977.17,AAK1ACCBicalutamideEAG3.6586e-03-0.5398image
chr2:69461572-69463973:-ACCAZD8055EER1.0317e-040.7212image
chr2:69461572-69463973:-BLCAAKT.inhibitor.VIIIEER2.6941e-030.2132image
ENSG00000115977.17,AAK1BLCABMS.536924EAG4.8275e-03-0.1956image
chr2:69461572-69463973:-BRCAAZD6482EER7.8811e-080.1898image
ENSG00000115977.17,AAK1BRCAAZD6482EAG2.0656e-060.1670image
chr2:69461572-69463973:-CESCAZD6482EER1.1199e-040.3143image
ENSG00000115977.17,AAK1CESCAZD6482EAG2.4014e-060.3673image
ENSG00000115977.17,AAK1COADFH535EAG2.3982e-030.2736image
chr2:69461572-69463973:-COADFH535EER7.5045e-030.2470image
chr2:69461572-69463973:-ESCABMS.509744EER1.3075e-03-0.2535image
ENSG00000115977.17,AAK1ESCABMS.509744EAG4.1826e-03-0.2253image
chr2:69461572-69463973:-GBMCMKEER6.8695e-030.2661image
ENSG00000115977.17,AAK1GBMGDC.0449EAG9.0107e-030.2525image
ENSG00000115977.17,AAK1HNSCAZD6482EAG3.6729e-070.2603image
chr2:69461572-69463973:-HNSCDocetaxelEER1.3841e-05-0.2247image
ENSG00000115977.17,AAK1KICHEtoposideEAG1.1146e-020.3596image
chr2:69461572-69463973:-KICHDoxorubicinEER9.4631e-030.3708image
ENSG00000115977.17,AAK1KIRCCyclopamineEAG1.6525e-03-0.1815image
chr2:69461572-69463973:-KIRCAZD6482EER5.9804e-050.2326image
chr2:69461572-69463973:-KIRPAZD.0530EER7.7232e-03-0.1903image
ENSG00000115977.17,AAK1KIRPAZD.0530EAG6.7649e-03-0.1919image
chr2:69461572-69463973:-LAMLGDC.0449EER1.9770e-03-0.2919image
ENSG00000115977.17,AAK1LAMLGDC.0449EAG3.0150e-04-0.3218image
chr2:69461572-69463973:-LGGEmbelinEER1.6684e-040.1862image
ENSG00000115977.17,AAK1LGGCMKEAG5.1322e-030.1371image
ENSG00000115977.17,AAK1LIHCGNF.2EAG3.0684e-030.3565image
chr2:69461572-69463973:-LIHCCGP.60474EER3.0869e-02-0.2767image
chr2:69461572-69463973:-LUADATRAEER4.2857e-040.1970image
ENSG00000115977.17,AAK1LUADATRAEAG2.3912e-040.2040image
chr2:69461572-69463973:-LUSCABT.888EER1.4709e-06-0.2366image
ENSG00000115977.17,AAK1LUSCABT.888EAG2.2714e-06-0.2321image
chr2:69461572-69463973:-OVBexaroteneEER5.6471e-060.2865image
ENSG00000115977.17,AAK1OVBexaroteneEAG3.2921e-050.2564image
ENSG00000115977.17,AAK1PAADCCT007093EAG8.6403e-030.2575image
chr2:69461572-69463973:-PAADCCT007093EER5.4841e-030.2758image
ENSG00000115977.17,AAK1PCPGGW.441756EAG4.1592e-04-0.3415image
chr2:69461572-69463973:-PCPGGW.441756EER1.3998e-04-0.3908image
chr2:69461572-69463973:-PRADAZD6482EER4.3751e-070.2563image
ENSG00000115977.17,AAK1PRADAZD6482EAG1.0058e-090.3037image
chr2:69461572-69463973:-READAMG.706EER2.0716e-020.3439image
ENSG00000115977.17,AAK1READAMG.706EAG2.2134e-020.3404image
ENSG00000115977.17,AAK1SARCMG.132EAG2.7829e-03-0.2372image
chr2:69461572-69463973:-SARCEmbelinEER2.1231e-030.2515image
chr2:69461572-69463973:-SKCMBMS.536924EER1.7536e-04-0.2146image
ENSG00000115977.17,AAK1SKCMBMS.536924EAG1.8698e-03-0.1765image
ENSG00000115977.17,AAK1STADAZD6482EAG3.7250e-050.2185image
chr2:69461572-69463973:-STADAZD6482EER4.3815e-030.1574image
chr2:69626579-69626821:-STADAZD6244EER2.2135e-02-0.4850image
chr2:69461572-69463973:-TGCTGDC.0449EER1.7445e-020.4240image
ENSG00000115977.17,AAK1TGCTGDC.0449EAG1.7445e-020.4240image
chr2:69461572-69463973:-THCAEmbelinEER7.7387e-110.3186image
ENSG00000115977.17,AAK1THCAEmbelinEAG5.7747e-120.3337image
chr2:69461572-69463973:-THYMImatinibEER2.7145e-030.4002image
ENSG00000115977.17,AAK1THYMImatinibEAG1.6488e-020.3137image
chr2:69461572-69463973:-UCECGDC0941EER3.6679e-020.3447image
ENSG00000115977.17,AAK1UCECElesclomolEAG3.4794e-02-0.3227image
ENSG00000115977.17,AAK1UCSBMS.509744EAG4.1416e-020.4381image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType
chr2:69511037-69511790:-ENST00000406297.6Q2M2I8DB12010FostamatinibSmallMoleculeDrug
chr2:69511037-69511790:-ENST00000409085.7Q2M2I8DB12010FostamatinibSmallMoleculeDrug