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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: HSPA4L (ImmuneEditome ID:22824)

1. Gene summary of enriched editing regions for HSPA4L

check button Gene summary
Gene informationGene symbol

HSPA4L

Gene ID

22824

GeneSynonymsAPG-1|APG1|HSPH3|Osp94
GeneCytomap

4q28.1

GeneTypeprotein-coding
GeneDescriptionheat shock 70 kDa protein 4L|HSPA4-like protein|heat shock 70 kDa protein 4-like protein|heat shock 70-related protein APG-1|heat shock 70kDa protein 4-like|heat shock protein (hsp110 family)|heat-shock protein family A member 4-like protein|osmotic stress protein 94|testis tissue sperm-binding protein Li 64n
GeneModificationdate20230329
UniprotIDO95757;D6RJ96;E9PDE8
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr4:127835397-127838126:+ENST00000296464.7ENSG00000164070.10HSPA4LUTR3AluSx,AluJb,AluY,AluSx1chr4:127835397-127838126:+.alignment
chr4:127839282-127840182:+ENST00000296464.7ENSG00000164070.10HSPA4LUTR3AluSx3,AluSxchr4:127839282-127840182:+.alignment


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2. Tumor-specific enriched editing regions for HSPA4L


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr4:127835397-127838126:+BRCAEER1.5811e-02image
chr4:127839282-127840182:+BRCAEER1.4927e-05image
ENSG00000164070.10,HSPA4LBRCAEAG1.4030e-06image
chr4:127835397-127838126:+HNSCEER3.2098e-08image
chr4:127839282-127840182:+HNSCEER2.0489e-05image
ENSG00000164070.10,HSPA4LHNSCEAG2.6321e-04image
ENSG00000164070.10,HSPA4LKIRCEAG5.4940e-04image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr4:127835397-127838126:+ACCPathEER2.0508e-036.9419e-030.4749image
chr4:127835397-127838126:+ESCACliEER3.3934e-023.3396e-02-0.3214image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr4:127835397-127838126:+BRCAEER1.2858e-022.9248e-025.4699e-03image

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3. Enriched editing regions and immune related genes for HSPA4L


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr4:127835397-127838126:+KICHEERENSG00000168769,TET2-0.67166.4059e-035.1262e-05-0.5097imageNNTET2B_cells_naiveGSVA_HALLMARK_UV_RESPONSE_DN
chr4:127835397-127838126:+KICHEERENSG00000126804,ZBTB1-0.67119.2760e-035.7262e-05-0.5069imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr4:127835397-127838126:+KICHEERENSG00000186376,ZNF75D-0.66161.0927e-021.4430e-05-0.5402imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr4:127835397-127838126:+KICHEERENSG00000138688,KIAA1109-0.66201.2131e-029.7657e-06-0.5490imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr4:127835397-127838126:+KICHEERENSG00000163110,PDLIM5-0.65201.4688e-021.5010e-05-0.5393imageNNPDLIM5T_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr4:127835397-127838126:+KICHEERENSG00000145388,METTL14-0.64341.7174e-024.0376e-06-0.5681imageNNMETTL14T_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr4:127835397-127838126:+KICHEERENSG00000183808,RBM12B-0.63931.7174e-021.5942e-05-0.5379imageNNNAB_cells_naiveGSVA_HALLMARK_PROTEIN_SECRETION
chr4:127835397-127838126:+KICHEERENSG00000165288,BRWD3-0.63991.7174e-027.9938e-05-0.4983imageNNNAEosinophilsGSVA_HALLMARK_PROTEIN_SECRETION
chr4:127835397-127838126:+KICHEERENSG00000109606,DHX15-0.63881.7174e-025.1182e-06-0.5631imageNNNAB_cells_naiveGSVA_HALLMARK_PROTEIN_SECRETION
chr4:127835397-127838126:+KICHEERENSG00000151458,ANKRD50-0.64041.7174e-021.1288e-04-0.4892imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr4:127839282-127840182:+PCPGEERENSG00000125898,FAM110A0.26382.0536e-026.6406e-090.4385imageNNNADendritic_cells_activatedGSVA_HALLMARK_DNA_REPAIR

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4. Enriched editing regions and immune related splicing for HSPA4L


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000164070.10,HSPA4L
CESCEAGMEXENSG00000110321.11chr1110798991:10799113:10799212:10799309:10799551:10799756:10800089:10800348-0.26602.8483e-025.9730e-10-0.4011imageNACIN1;ADAR;BCCIP;BUD13;CAPRIN1;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;ZC3H7B;ZNF184NAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000164070.10,HSPA4L
CESCEAGMEXENSG00000110321.11chr1110798991:10799113:10799212:10799305:10799551:10799756:10800089:10800348-0.26602.8509e-026.2824e-10-0.4006imageNACIN1;ADAR;BCCIP;BUD13;CAPRIN1;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;ZC3H7B;ZNF184NAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000164070.10,HSPA4L
CESCEAGMEXENSG00000090861.11chr1670261043:70261157:70262345:70262524:70265537:70265662:70267658:70267796-0.26332.9800e-022.9557e-13-0.4650imageNACIN1;ADAR;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;ZC3H7B;ZNF184NAGSVA_HALLMARK_MITOTIC_SPINDLE
chr4:127835397-127838126:+
ESCAEERIRENSG00000175711.4chr1782942154:82944049:82946878:82946959-0.41106.9311e-038.1908e-06-0.4316imageNNB3GNTL1T_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr4:127835397-127838126:+
ESCAEERIRENSG00000136448.7chr1745105643:45105877:45108677:45109016-0.42311.0891e-022.7649e-06-0.4195imageNNNANK_cells_activatedGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr4:127835397-127838126:+
ESCAEERA3ENSG00000139211.5chr1247079461:47079642:47076497:47079248:47076497:470790650.33714.4835e-023.8773e-050.4090imageNNAMIGO2T_cells_regulatory_(Tregs)GSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr4:127835397-127838126:+
ESCAEERIRENSG00000166685.7chr1773206707:73207256:73208313:73208420-0.39721.7834e-021.4644e-06-0.4299imageNNNAMacrophages_M2GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr4:127835397-127838126:+
ESCAEERIRENSG00000116957.8chr1235448348:235448440:235448669:235448899-0.38583.0855e-022.3275e-07-0.4581imageNNNADendritic_cells_restingGSVA_HALLMARK_HEDGEHOG_SIGNALING
chr4:127835397-127838126:+
ESCAEERMEXENSG00000104131.8chr1544550875:44550930:44551430:44551522:44554550:44554667:44557488:445576500.39801.8077e-027.4835e-060.4025imageNNNANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr4:127835397-127838126:+
ESCAEERA3ENSG00000082497.7chr1210239492:210239608:210245799:210245927:210241557:2102459270.35971.2347e-023.2246e-060.4593imageNNNAMast_cells_restingGSVA_HALLMARK_UV_RESPONSE_DN

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5. Enriched editing regions and immune infiltration for HSPA4L


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr4:127835397-127838126:+ACCEERMacrophages_M21.7938e-03-0.5381image
chr4:127839282-127840182:+ACCEERMacrophages_M19.0685e-030.3288image
ENSG00000164070.10,HSPA4LACCEAGT_cells_CD81.2855e-020.3118image
chr4:127835397-127838126:+BLCAEERMast_cells_activated3.4058e-020.3494image
ENSG00000164070.10,HSPA4LBLCAEAGT_cells_CD83.6301e-020.2438image
chr4:127839282-127840182:+BRCAEERMast_cells_resting7.0035e-030.1781image
ENSG00000164070.10,HSPA4LBRCAEAGT_cells_CD4_memory_resting1.8696e-020.1376image
chr4:127835397-127838126:+CESCEERMast_cells_activated3.4784e-02-0.1686image
chr4:127839282-127840182:+CESCEERDendritic_cells_activated6.1437e-030.1917image
ENSG00000164070.10,HSPA4LCESCEAGNK_cells_resting3.6315e-020.1409image
chr4:127835397-127838126:+COADEERB_cells_memory1.6353e-050.7189image
ENSG00000164070.10,HSPA4LCOADEAGNeutrophils3.0370e-030.3960image
chr4:127835397-127838126:+ESCAEERDendritic_cells_resting5.7933e-03-0.2547image
chr4:127839282-127840182:+ESCAEERDendritic_cells_resting3.4191e-02-0.2003image
ENSG00000164070.10,HSPA4LESCAEAGDendritic_cells_resting3.7723e-03-0.2533image
chr4:127835397-127838126:+GBMEERMast_cells_resting3.0414e-020.2730image
chr4:127839282-127840182:+GBMEERT_cells_gamma_delta4.0062e-020.2007image
ENSG00000164070.10,HSPA4LGBMEAGT_cells_follicular_helper4.7949e-02-0.1849image
chr4:127835397-127838126:+HNSCEERPlasma_cells8.6307e-03-0.1429image
chr4:127839282-127840182:+HNSCEERPlasma_cells1.7425e-03-0.1661image
ENSG00000164070.10,HSPA4LHNSCEAGT_cells_CD4_memory_resting1.9334e-040.1856image
chr4:127835397-127838126:+KICHEERMacrophages_M11.2338e-020.3294image
ENSG00000164070.10,HSPA4LKICHEAGB_cells_memory5.2337e-040.4345image
chr4:127835397-127838126:+KIRCEERT_cells_regulatory_(Tregs)3.4945e-030.1785image
chr4:127839282-127840182:+KIRCEERT_cells_CD4_memory_resting1.8884e-02-0.1376image
chr4:127835397-127838126:+KIRPEERNK_cells_resting1.5959e-030.2692image
chr4:127839282-127840182:+KIRPEERT_cells_CD4_memory_activated7.2027e-030.2036image
ENSG00000164070.10,HSPA4LKIRPEAGNK_cells_resting1.4629e-030.2224image
chr4:127835397-127838126:+LGGEERMacrophages_M22.1965e-020.1443image
chr4:127839282-127840182:+LGGEERMacrophages_M23.0125e-050.2424image
ENSG00000164070.10,HSPA4LLGGEAGMacrophages_M22.5015e-030.1637image
chr4:127835397-127838126:+LIHCEERNK_cells_resting1.7514e-030.4909image
chr4:127839282-127840182:+LIHCEERMonocytes4.2039e-020.1875image
ENSG00000164070.10,HSPA4LLIHCEAGMonocytes6.0811e-030.2461image
chr4:127835397-127838126:+LUADEERT_cells_CD4_memory_resting3.3981e-02-0.4536image
ENSG00000164070.10,HSPA4LLUADEAGNK_cells_resting2.3947e-020.3159image
chr4:127835397-127838126:+LUSCEERDendritic_cells_activated1.9277e-040.2775image
chr4:127839282-127840182:+LUSCEERT_cells_gamma_delta4.7804e-020.1394image
ENSG00000164070.10,HSPA4LLUSCEAGMast_cells_activated1.2400e-020.1619image
chr4:127839282-127840182:+OVEERT_cells_regulatory_(Tregs)3.1880e-030.5464image
ENSG00000164070.10,HSPA4LOVEAGT_cells_regulatory_(Tregs)1.1920e-020.4460image
ENSG00000164070.10,HSPA4LPAADEAGMonocytes9.0071e-03-0.5318image
chr4:127835397-127838126:+PCPGEERT_cells_regulatory_(Tregs)8.3937e-030.2718image
chr4:127839282-127840182:+PCPGEERT_cells_CD83.7489e-030.2279image
ENSG00000164070.10,HSPA4LPCPGEAGT_cells_CD83.4711e-020.1645image
ENSG00000164070.10,HSPA4LPRADEAGPlasma_cells4.9424e-030.4776image
chr4:127835397-127838126:+SARCEERB_cells_memory3.5705e-020.3418image
chr4:127839282-127840182:+SARCEERNK_cells_activated8.0713e-040.4146image
ENSG00000164070.10,HSPA4LSARCEAGNK_cells_activated3.0347e-020.2554image
ENSG00000164070.10,HSPA4LSKCMEAGMacrophages_M12.7387e-02-0.2133image
chr4:127835397-127838126:+STADEERMast_cells_resting1.3041e-03-0.2602image
chr4:127839282-127840182:+STADEERPlasma_cells6.9748e-030.2304image
ENSG00000164070.10,HSPA4LSTADEAGMacrophages_M01.4452e-030.2397image
ENSG00000164070.10,HSPA4LTHCAEAGT_cells_CD4_memory_activated7.2853e-040.3746image
chr4:127835397-127838126:+THYMEERT_cells_gamma_delta1.1915e-020.4685image
chr4:127839282-127840182:+UCECEERT_cells_regulatory_(Tregs)7.1070e-030.5568image
ENSG00000164070.10,HSPA4LUCECEAGT_cells_regulatory_(Tregs)5.9700e-030.5666image


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6. Enriched editing regions and immune gene sets for HSPA4L


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr4:127839282-127840182:+HNSCEER1.4675e-03image2.1404e-050.2241image
ENSG00000164070.10,HSPA4LHNSCEAG3.3553e-03image1.1296e-080.2810image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000164070.10,HSPA4LACCGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.8333e-020.2964image
chr4:127839282-127840182:+ACCGSVA_HALLMARK_IL2_STAT5_SIGNALINGEER1.2687e-030.4002image
chr4:127835397-127838126:+ACCGSVA_HALLMARK_G2M_CHECKPOINTEER9.3421e-040.5647image
chr4:127839282-127840182:+BRCAGSVA_HALLMARK_E2F_TARGETSEER2.3017e-06-0.3070image
ENSG00000164070.10,HSPA4LBRCAGSVA_HALLMARK_MYC_TARGETS_V2EAG1.2797e-03-0.1876image
chr4:127835397-127838126:+CESCGSVA_HALLMARK_MITOTIC_SPINDLEEER1.4859e-02-0.1941image
chr4:127839282-127840182:+CESCGSVA_HALLMARK_G2M_CHECKPOINTEER9.7821e-03-0.1809image
ENSG00000164070.10,HSPA4LCOADGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG3.2071e-050.5340image
ENSG00000164070.10,HSPA4LESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.3419e-030.2496image
chr4:127839282-127840182:+ESCAGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.3559e-03-0.2991image
chr4:127835397-127838126:+ESCAGSVA_HALLMARK_DNA_REPAIREER2.3735e-030.2796image
chr4:127839282-127840182:+GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.5006e-030.2691image
chr4:127835397-127838126:+GBMGSVA_HALLMARK_MITOTIC_SPINDLEEER4.7037e-03-0.3517image
ENSG00000164070.10,HSPA4LGBMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG3.2718e-02-0.1993image
chr4:127839282-127840182:+HNSCGSVA_HALLMARK_COAGULATIONEER6.5279e-070.2611image
chr4:127835397-127838126:+HNSCGSVA_HALLMARK_COAGULATIONEER1.7738e-040.2029image
ENSG00000164070.10,HSPA4LHNSCGSVA_HALLMARK_KRAS_SIGNALING_UPEAG2.0003e-090.2945image
chr4:127835397-127838126:+KICHGSVA_HALLMARK_UV_RESPONSE_DNEER3.3484e-04-0.4585image
chr4:127835397-127838126:+KIRCGSVA_HALLMARK_DNA_REPAIREER7.0327e-050.2413image
chr4:127839282-127840182:+KIRCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER7.5809e-040.1963image
chr4:127839282-127840182:+KIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.9166e-020.1780image
chr4:127835397-127838126:+KIRPGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER5.9094e-03-0.2358image
ENSG00000164070.10,HSPA4LKIRPGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.1260e-030.2010image
chr4:127835397-127838126:+LGGGSVA_HALLMARK_SPERMATOGENESISEER1.4470e-04-0.2371image
chr4:127839282-127840182:+LGGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.3332e-050.2526image
ENSG00000164070.10,HSPA4LLGGGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG2.0796e-040.2002image
chr4:127839282-127840182:+LIHCGSVA_HALLMARK_NOTCH_SIGNALINGEER4.5183e-03-0.2597image
chr4:127835397-127838126:+LIHCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER7.1633e-03-0.4292image
chr4:127835397-127838126:+LUADGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER3.7638e-020.4457image
chr4:127835397-127838126:+LUSCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER8.0487e-030.1992image
chr4:127839282-127840182:+LUSCGSVA_HALLMARK_MYC_TARGETS_V2EER5.1309e-03-0.1962image
chr4:127839282-127840182:+OVGSVA_HALLMARK_UV_RESPONSE_DNEER2.5975e-02-0.4279image
ENSG00000164070.10,HSPA4LOVGSVA_HALLMARK_UV_RESPONSE_DNEAG2.8979e-02-0.3925image
ENSG00000164070.10,HSPA4LPAADGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.6925e-030.5960image
chr4:127839282-127840182:+PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.0506e-050.3406image
ENSG00000164070.10,HSPA4LPCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.4335e-050.3123image
chr4:127835397-127838126:+PCPGGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.1202e-030.3148image
ENSG00000164070.10,HSPA4LPRADGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.8224e-020.4086image
chr4:127835397-127838126:+SARCGSVA_HALLMARK_SPERMATOGENESISEER2.6019e-02-0.3609image
ENSG00000164070.10,HSPA4LSARCGSVA_HALLMARK_KRAS_SIGNALING_DNEAG4.2206e-03-0.3333image
chr4:127839282-127840182:+SARCGSVA_HALLMARK_PROTEIN_SECRETIONEER2.2533e-020.2894image
ENSG00000164070.10,HSPA4LSKCMGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG1.7781e-030.2987image
chr4:127835397-127838126:+STADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.7455e-030.2535image
ENSG00000164070.10,HSPA4LTHCAGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.8023e-02-0.2672image
chr4:127835397-127838126:+THYMGSVA_HALLMARK_APICAL_JUNCTIONEER4.1717e-020.3873image
ENSG00000164070.10,HSPA4LUCECGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG1.6562e-020.5048image
chr4:127839282-127840182:+UCECGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER1.7186e-020.5024image


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7. Enriched editing regions and drugs for HSPA4L


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000164070.10,HSPA4LACCCI.1040EAG2.7745e-02-0.2774image
chr4:127839282-127840182:+ACCAZ628EER2.7687e-03-0.3738image
ENSG00000164070.10,HSPA4LBLCAJNK.Inhibitor.VIIIEAG1.5381e-02-0.2808image
chr4:127835397-127838126:+BLCACGP.082996EER1.2318e-02-0.4074image
chr4:127839282-127840182:+BRCACCT007093EER7.7564e-05-0.2587image
ENSG00000164070.10,HSPA4LBRCAGW843682XEAG8.3037e-050.2282image
ENSG00000164070.10,HSPA4LCESCJW.7.52.1EAG3.1787e-05-0.2760image
chr4:127839282-127840182:+CESCJW.7.52.1EER3.6249e-08-0.3747image
chr4:127835397-127838126:+CESCAS601245EER4.9895e-03-0.2230image
ENSG00000164070.10,HSPA4LCHOLCEP.701EAG5.3166e-03-0.5984image
chr4:127835397-127838126:+COADGNF.2EER1.0904e-02-0.4736image
ENSG00000164070.10,HSPA4LCOADBX.795EAG3.1311e-03-0.3948image
chr4:127839282-127840182:+ESCAJNJ.26854165EER1.8366e-050.3945image
ENSG00000164070.10,HSPA4LESCAJNJ.26854165EAG4.2200e-030.2513image
chr4:127835397-127838126:+ESCABMS.536924EER2.9472e-04-0.3302image
ENSG00000164070.10,HSPA4LGBMAS601245EAG1.5945e-02-0.2243image
chr4:127835397-127838126:+GBMLenalidomideEER3.5010e-040.4364image
chr4:127839282-127840182:+GBMCGP.60474EER5.4735e-04-0.3317image
ENSG00000164070.10,HSPA4LHNSCBexaroteneEAG5.4924e-09-0.2867image
chr4:127839282-127840182:+HNSCBexaroteneEER1.3838e-07-0.2759image
chr4:127835397-127838126:+HNSCBMS.509744EER7.9182e-10-0.3268image
ENSG00000164070.10,HSPA4LKICHA.443654EAG3.9521e-030.3667image
chr4:127835397-127838126:+KICHEmbelinEER3.2076e-040.4598image
chr4:127839282-127840182:+KIRCGDC.0449EER3.7950e-03-0.1692image
chr4:127835397-127838126:+KIRCBMS.536924EER2.5139e-09-0.3551image
ENSG00000164070.10,HSPA4LKIRCLFM.A13EAG1.9222e-030.1714image
chr4:127835397-127838126:+KIRPCamptothecinEER1.0819e-02-0.2187image
ENSG00000164070.10,HSPA4LKIRPAS601245EAG6.4989e-040.2379image
chr4:127839282-127840182:+KIRPFTI.277EER4.5768e-040.2636image
chr4:127835397-127838126:+LGGErlotinibEER1.2418e-05-0.2720image
chr4:127839282-127840182:+LGGAKT.inhibitor.VIIIEER3.1515e-11-0.3770image
ENSG00000164070.10,HSPA4LLGGAKT.inhibitor.VIIIEAG1.3567e-07-0.2815image
ENSG00000164070.10,HSPA4LLIHCBI.2536EAG1.1114e-020.2282image
chr4:127839282-127840182:+LIHCBI.2536EER4.1605e-030.2620image
chr4:127835397-127838126:+LIHCGW843682XEER1.1711e-050.6463image
ENSG00000164070.10,HSPA4LLUADGW.441756EAG7.4319e-030.3706image
chr4:127835397-127838126:+LUADGW.441756EER2.8010e-020.4681image
chr4:127839282-127840182:+LUSCErlotinibEER4.4879e-030.1992image
chr4:127835397-127838126:+LUSCBleomycinEER4.0003e-03-0.2159image
ENSG00000164070.10,HSPA4LLUSCEtoposideEAG2.0307e-02-0.1504image
ENSG00000164070.10,HSPA4LOVBexaroteneEAG4.2726e-030.4990image
chr4:127839282-127840182:+OVBexaroteneEER3.2525e-040.6399image
ENSG00000164070.10,HSPA4LPAADAKT.inhibitor.VIIIEAG8.0102e-04-0.6493image
chr4:127835397-127838126:+PCPGBMS.536924EER2.0381e-04-0.3760image
ENSG00000164070.10,HSPA4LPCPGAZD6244EAG1.5049e-03-0.2452image
chr4:127839282-127840182:+PCPGAZD6244EER1.6379e-05-0.3335image
ENSG00000164070.10,HSPA4LPRADAZD7762EAG2.4404e-030.5098image
chr4:127839282-127840182:+SARCBIRB.0796EER1.5967e-02-0.3049image
chr4:127835397-127838126:+SARCAS601245EER5.8086e-03-0.4392image
ENSG00000164070.10,HSPA4LSARCAS601245EAG2.3107e-03-0.3536image
chr4:127835397-127838126:+SKCMBAY.61.3606EER8.6890e-03-0.3182image
ENSG00000164070.10,HSPA4LSKCMBIBW2992EAG1.7806e-020.2287image
chr4:127835397-127838126:+STADImatinibEER1.3441e-030.2595image
chr4:127839282-127840182:+STADBleomycinEER1.2988e-020.2125image
ENSG00000164070.10,HSPA4LSTADGSK.650394EAG4.1231e-030.2164image
ENSG00000164070.10,HSPA4LTHCALenalidomideEAG3.4294e-03-0.3274image
ENSG00000164070.10,HSPA4LTHYMDocetaxelEAG9.4875e-040.3919image
chr4:127835397-127838126:+THYMEpothilone.BEER9.7084e-030.4802image
ENSG00000164070.10,HSPA4LUCECLFM.A13EAG1.2148e-02-0.5248image
chr4:127839282-127840182:+UCECLFM.A13EER1.4486e-02-0.5136image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType