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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: WAC-AS1 (ImmuneEditome ID:220906)

1. Gene summary of enriched editing regions for WAC-AS1

check button Gene summary
Gene informationGene symbol

WAC-AS1

Gene ID

220906

GeneSynonyms-
GeneCytomap

10p12.1

GeneTypencRNA
GeneDescription-
GeneModificationdate20230329
UniprotID.
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr10:28522999-28523779:-ENST00000527986.4ENSG00000254635.4WAC-AS1ncRNA_exonicL1M4,AluSc,AluSpchr10:28522999-28523779:-.alignment
chr10:28522999-28523779:-ENST00000528337.1ENSG00000254635.4WAC-AS1ncRNA_exonicL1M4,AluSc,AluSpchr10:28522999-28523779:-.alignment
chr10:28525066-28525791:-ENST00000527986.4ENSG00000254635.4WAC-AS1ncRNA_intronicL1M4,AluSx1,AluSqchr10:28525066-28525791:-.alignment
chr10:28525066-28525791:-ENST00000528337.1ENSG00000254635.4WAC-AS1ncRNA_intronicL1M4,AluSx1,AluSqchr10:28525066-28525791:-.alignment


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2. Tumor-specific enriched editing regions for WAC-AS1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr10:28525066-28525791:-BRCAEER6.0176e-05image
ENSG00000254635.4,WAC-AS1COADEAG2.3495e-02image
chr10:28525066-28525791:-HNSCEER1.2268e-02image
ENSG00000254635.4,WAC-AS1HNSCEAG4.8501e-03image
ENSG00000254635.4,WAC-AS1KICHEAG3.5531e-02image
chr10:28525066-28525791:-KIRPEER4.8329e-02image
chr10:28522999-28523779:-LUADEER3.0105e-02image
chr10:28525066-28525791:-LUSCEER9.4879e-06image
chr10:28525066-28525791:-THCAEER1.9961e-02image
ENSG00000254635.4,WAC-AS1UCECEAG2.4933e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000254635.4,WAC-AS1KIRCPathEAG3.2641e-023.6793e-02-0.0953image
ENSG00000254635.4,WAC-AS1LIHCPathEAG1.0252e-022.0768e-030.1823image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for WAC-AS1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr10:28525066-28525791:-OVEERENSG00000130255,RPL360.37008.4429e-071.4932e-110.4019imageNU2AF2NAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr10:28525066-28525791:-OVEERENSG00000130332,LSM70.36481.6467e-061.1830e-110.4037imageNU2AF2NAT_cells_CD8GSVA_HALLMARK_UV_RESPONSE_DN
chr10:28525066-28525791:-OVEERENSG00000115268,RPS150.36211.7130e-062.4314e-130.4328imageNU2AF2NAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr10:28525066-28525791:-OVEERENSG00000169253,RP11-220D10.10.36102.1803e-067.0018e-130.4252imageNNNANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr10:28525066-28525791:-OVEERENSG00000230629,RPS23P80.35622.4125e-061.8580e-110.4002imageNNNANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr10:28525066-28525791:-OVEERENSG00000233762,AC007969.50.35283.9429e-061.9054e-130.4346imageNNNAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr10:28525066-28525791:-OVEERENSG00000130255,RPL360.37008.4429e-071.4932e-110.4019imageNU2AF2NAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr10:28525066-28525791:-OVEERENSG00000130332,LSM70.36481.6467e-061.1830e-110.4037imageNU2AF2NAT_cells_CD8GSVA_HALLMARK_UV_RESPONSE_DN
chr10:28525066-28525791:-OVEERENSG00000115268,RPS150.36211.7130e-062.4314e-130.4328imageNU2AF2NAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr10:28525066-28525791:-OVEERENSG00000169253,RP11-220D10.10.36102.1803e-067.0018e-130.4252imageNNNANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr10:28525066-28525791:-OVEERENSG00000230629,RPS23P80.35622.4125e-061.8580e-110.4002imageNNNANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr10:28525066-28525791:-OVEERENSG00000233762,AC007969.50.35283.9429e-061.9054e-130.4346imageNNNAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE

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4. Enriched editing regions and immune related splicing for WAC-AS1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000254635.4,WAC-AS1
DLBCEAGMEXENSG00000104529.13chr8143586753:143586852:143592714:143592893:143596878:143597074:143597347:143597415-0.72503.5041e-022.7098e-06-0.7012imageNADAR;AIFM1;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;LSM11;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TRA2A;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAPlasma_cells
ENSG00000254635.4,WAC-AS1
GBMEAGIRENSG00000132128.12chr146280191:46280290:46281124:46281161-0.31447.4623e-031.2105e-06-0.4152imageNADAR;AIFM1;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;LSM11;MBNL2;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TRA2A;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAMonocytesGSVA_HALLMARK_PROTEIN_SECRETION
chr10:28525066-28525791:-
OVEERIRENSG00000162613.12chr177944054:77946576:77947452:77947547-0.35192.8119e-066.7821e-11-0.4075imageNU2AF2NAT_cells_CD8GSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000254635.4,WAC-AS1
TGCTEAGMEXENSG00000188690.8chr10125788724:125789005:125789186:125789363:125794021:125794388:125794879:125794978-0.31571.5427e-023.6510e-05-0.4344imageNADAR;AIFM1;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DIS3L2;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHSRP;LIN28;LIN28B;LSM11;MBNL2;MOV10;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TRA2A;U2AF1;U2AF2;UPF1;VIM;XRN2;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_GLYCOLYSIS
ENSG00000254635.4,WAC-AS1
TGCTEAGMEXENSG00000188690.8chr10125788724:125789005:125789186:125789363:125794262:125794388:125794879:125794978-0.28923.2659e-025.3623e-05-0.4307imageNADAR;AIFM1;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DIS3L2;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHSRP;LIN28;LIN28B;LSM11;MBNL2;MOV10;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TRA2A;U2AF1;U2AF2;UPF1;VIM;XRN2;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_GLYCOLYSIS
ENSG00000254635.4,WAC-AS1
TGCTEAGMEXENSG00000188690.8chr10125788724:125789005:125789186:125789363:125792578:125794388:125794879:125794978-0.32201.1983e-022.3357e-05-0.4464imageNADAR;AIFM1;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DIS3L2;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHSRP;LIN28;LIN28B;LSM11;MBNL2;MOV10;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TRA2A;U2AF1;U2AF2;UPF1;VIM;XRN2;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_GLYCOLYSIS
ENSG00000254635.4,WAC-AS1
TGCTEAGIRENSG00000179091.4chr8144095038:144095673:144095832:1440960290.27614.2000e-022.4625e-040.4038imageNAIFM1;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;LSM11;MBNL2;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TRA2A;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZNF184NAMacrophages_M0GSVA_HALLMARK_MYC_TARGETS_V2
ENSG00000254635.4,WAC-AS1
TGCTEAGIRENSG00000055950.12chr10100981375:100983817:100984033:1009840740.27014.9491e-026.8761e-050.4203imageNADAR;AIFM1;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LIN28;LIN28B;LSM11;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM47;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TRA2A;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDF1;ZC3H7B;ZNF184NANK_cells_activatedGSVA_HALLMARK_MTORC1_SIGNALING
ENSG00000254635.4,WAC-AS1
TGCTEAGA5ENSG00000153914.11chr566159218:66159334:66153462:66153596:66153462:66158932-0.32491.6595e-021.9083e-06-0.4641imageNADAR;AIFM1;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DIS3L2;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;LSM11;MBNL2;METTL14;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TRA2A;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAMacrophages_M2GSVA_HALLMARK_GLYCOLYSIS
ENSG00000254635.4,WAC-AS1
THYMEAGA3ENSG00000174500.8chr3112125225:112125254:112120840:112123772:112120840:1121237750.28343.2251e-022.2705e-050.4284imageNFUS;TAF15GCSAMT_cells_gamma_deltaGSVA_HALLMARK_ADIPOGENESIS

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5. Enriched editing regions and immune infiltration for WAC-AS1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000254635.4,WAC-AS1ACCEAGT_cells_CD4_memory_resting1.0779e-020.3353image
chr10:28522999-28523779:-BLCAEERB_cells_memory1.2734e-02-0.2196image
ENSG00000254635.4,WAC-AS1BLCAEAGB_cells_naive5.9243e-030.1444image
chr10:28522999-28523779:-BRCAEERT_cells_follicular_helper2.2704e-020.1129image
chr10:28525066-28525791:-BRCAEERPlasma_cells4.0206e-040.1139image
ENSG00000254635.4,WAC-AS1BRCAEAGMacrophages_M11.3278e-05-0.1377image
ENSG00000254635.4,WAC-AS1CESCEAGDendritic_cells_activated1.6172e-02-0.1591image
chr10:28522999-28523779:-COADEERNeutrophils8.0101e-080.7320image
ENSG00000254635.4,WAC-AS1COADEAGDendritic_cells_activated3.7023e-020.1615image
chr10:28522999-28523779:-ESCAEERNK_cells_resting4.0394e-020.1976image
ENSG00000254635.4,WAC-AS1ESCAEAGDendritic_cells_activated2.1330e-02-0.1842image
chr10:28522999-28523779:-GBMEERT_cells_CD4_memory_resting2.1751e-030.3108image
ENSG00000254635.4,WAC-AS1GBMEAGMacrophages_M01.0523e-040.3361image
chr10:28525066-28525791:-HNSCEERB_cells_naive1.1472e-02-0.1414image
ENSG00000254635.4,WAC-AS1HNSCEAGT_cells_follicular_helper3.2467e-030.1514image
chr10:28522999-28523779:-KIRCEERPlasma_cells9.4907e-030.2242image
ENSG00000254635.4,WAC-AS1KIRCEAGMast_cells_resting4.5139e-040.1881image
chr10:28525066-28525791:-KIRPEERMacrophages_M29.4056e-030.1646image
ENSG00000254635.4,WAC-AS1KIRPEAGT_cells_CD83.6067e-03-0.1785image
ENSG00000254635.4,WAC-AS1LAMLEAGEosinophils1.7082e-020.2174image
chr10:28525066-28525791:-LGGEERDendritic_cells_activated2.3405e-020.1018image
ENSG00000254635.4,WAC-AS1LGGEAGMacrophages_M19.1901e-04-0.1475image
chr10:28522999-28523779:-LIHCEERT_cells_regulatory_(Tregs)1.3233e-02-0.1541image
chr10:28525066-28525791:-LIHCEERMacrophages_M22.6986e-02-0.1653image
ENSG00000254635.4,WAC-AS1LIHCEAGMacrophages_M01.3434e-030.1843image
ENSG00000254635.4,WAC-AS1LUADEAGT_cells_CD4_memory_activated1.2238e-04-0.1855image
chr10:28522999-28523779:-LUSCEERT_cells_gamma_delta2.1713e-020.1660image
chr10:28525066-28525791:-LUSCEEREosinophils9.1747e-030.1349image
ENSG00000254635.4,WAC-AS1LUSCEAGT_cells_CD4_memory_resting6.6080e-030.1341image
ENSG00000254635.4,WAC-AS1MESOEAGPlasma_cells4.9748e-020.2305image
chr10:28522999-28523779:-OVEERT_cells_CD83.3930e-020.1402image
chr10:28525066-28525791:-OVEERT_cells_CD86.0419e-030.1695image
ENSG00000254635.4,WAC-AS1OVEAGT_cells_follicular_helper6.7083e-03-0.1617image
chr10:28525066-28525791:-PAADEERT_cells_CD4_memory_resting2.6657e-020.1786image
ENSG00000254635.4,WAC-AS1PRADEAGNK_cells_resting2.9697e-02-0.1014image
ENSG00000254635.4,WAC-AS1READEAGT_cells_CD4_naive1.5699e-020.2941image
ENSG00000254635.4,WAC-AS1SARCEAGT_cells_CD4_memory_activated4.6371e-02-0.1348image
chr10:28522999-28523779:-SKCMEERDendritic_cells_activated2.4536e-050.3734image
chr10:28522999-28523779:-STADEERT_cells_gamma_delta4.2056e-060.3026image
chr10:28525066-28525791:-STADEERT_cells_CD4_memory_activated7.0672e-040.1823image
ENSG00000254635.4,WAC-AS1STADEAGMacrophages_M29.7899e-030.1381image
ENSG00000254635.4,WAC-AS1THCAEAGT_cells_CD4_memory_activated2.2507e-03-0.1415image
ENSG00000254635.4,WAC-AS1THYMEAGNK_cells_resting1.3924e-02-0.2308image
chr10:28522999-28523779:-UCECEEREosinophils4.7062e-060.5922image
chr10:28525066-28525791:-UCECEERNeutrophils1.3573e-020.2152image
ENSG00000254635.4,WAC-AS1UCECEAGT_cells_CD4_memory_resting4.4703e-040.2928image
ENSG00000254635.4,WAC-AS1UVMEAGT_cells_CD4_naive1.3704e-020.3431image


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6. Enriched editing regions and immune gene sets for WAC-AS1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000254635.4,WAC-AS1BLCAEAG6.9230e-05-0.20764.9218e-03-0.14753.4218e-05-0.21591.3047e-02-0.1304image
ENSG00000254635.4,WAC-AS1LUADEAG8.8070e-06-0.21401.8747e-05-0.20624.1202e-04-0.17081.5601e-07-0.2514image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr10:28525066-28525791:-BLCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.8237e-020.1077image
ENSG00000254635.4,WAC-AS1BLCAGSVA_HALLMARK_GLYCOLYSISEAG4.0599e-04-0.1849image
chr10:28522999-28523779:-BRCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER8.7152e-03-0.1299image
chr10:28525066-28525791:-BRCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.4134e-050.1396image
ENSG00000254635.4,WAC-AS1BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.4161e-12-0.2151image
ENSG00000254635.4,WAC-AS1CESCGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.2156e-040.2423image
ENSG00000254635.4,WAC-AS1CHOLGSVA_HALLMARK_COAGULATIONEAG2.6159e-030.5466image
ENSG00000254635.4,WAC-AS1COADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG1.4105e-04-0.2904image
chr10:28522999-28523779:-COADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER4.0499e-04-0.5325image
chr10:28525066-28525791:-ESCAGSVA_HALLMARK_MITOTIC_SPINDLEEER8.0035e-03-0.2130image
ENSG00000254635.4,WAC-AS1ESCAGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG9.0075e-04-0.2632image
chr10:28522999-28523779:-ESCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER3.0811e-020.2079image
ENSG00000254635.4,WAC-AS1GBMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.1234e-04-0.3348image
chr10:28522999-28523779:-HNSCGSVA_HALLMARK_UV_RESPONSE_UPEER2.4843e-020.1594image
chr10:28525066-28525791:-HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.3329e-020.1384image
ENSG00000254635.4,WAC-AS1HNSCGSVA_HALLMARK_SPERMATOGENESISEAG2.1623e-050.2172image
ENSG00000254635.4,WAC-AS1KICHGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.6813e-03-0.4251image
chr10:28522999-28523779:-KIRCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER4.9864e-020.1704image
chr10:28525066-28525791:-KIRCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER5.6781e-03-0.1519image
ENSG00000254635.4,WAC-AS1KIRCGSVA_HALLMARK_COAGULATIONEAG1.3446e-02-0.1332image
ENSG00000254635.4,WAC-AS1KIRPGSVA_HALLMARK_KRAS_SIGNALING_DNEAG7.0206e-04-0.2073image
chr10:28525066-28525791:-KIRPGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER2.3854e-060.2944image
ENSG00000254635.4,WAC-AS1LAMLGSVA_HALLMARK_ANDROGEN_RESPONSEEAG5.9063e-03-0.2499image
ENSG00000254635.4,WAC-AS1LGGGSVA_HALLMARK_GLYCOLYSISEAG1.6467e-02-0.1070image
chr10:28525066-28525791:-LGGGSVA_HALLMARK_SPERMATOGENESISEER3.1162e-07-0.2273image
chr10:28522999-28523779:-LIHCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER6.5763e-070.3038image
chr10:28525066-28525791:-LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.9477e-020.1745image
ENSG00000254635.4,WAC-AS1LIHCGSVA_HALLMARK_COAGULATIONEAG5.3886e-09-0.3288image
chr10:28522999-28523779:-LUADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.1183e-02-0.1481image
chr10:28525066-28525791:-LUADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER1.7787e-030.1674image
ENSG00000254635.4,WAC-AS1LUADGSVA_HALLMARK_GLYCOLYSISEAG3.2293e-09-0.2824image
chr10:28525066-28525791:-LUSCGSVA_HALLMARK_SPERMATOGENESISEER1.7427e-02-0.1232image
chr10:28522999-28523779:-LUSCGSVA_HALLMARK_SPERMATOGENESISEER1.7013e-020.1725image
ENSG00000254635.4,WAC-AS1LUSCGSVA_HALLMARK_DNA_REPAIREAG2.0944e-05-0.2087image
ENSG00000254635.4,WAC-AS1MESOGSVA_HALLMARK_BILE_ACID_METABOLISMEAG4.6309e-020.2340image
chr10:28522999-28523779:-OVGSVA_HALLMARK_MITOTIC_SPINDLEEER1.5552e-03-0.2079image
chr10:28525066-28525791:-OVGSVA_HALLMARK_MITOTIC_SPINDLEEER3.8212e-07-0.3081image
ENSG00000254635.4,WAC-AS1OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.2963e-03-0.1815image
chr10:28525066-28525791:-PAADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER2.8561e-02-0.1765image
ENSG00000254635.4,WAC-AS1PAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.6509e-02-0.1738image
ENSG00000254635.4,WAC-AS1PCPGGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG7.3354e-03-0.2265image
ENSG00000254635.4,WAC-AS1READGSVA_HALLMARK_P53_PATHWAYEAG2.3814e-03-0.3651image
chr10:28525066-28525791:-SARCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER4.0673e-020.1445image
ENSG00000254635.4,WAC-AS1SARCGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.3403e-030.2046image
ENSG00000254635.4,WAC-AS1SKCMGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.0545e-020.1375image
chr10:28522999-28523779:-SKCMGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.8474e-030.2803image
chr10:28522999-28523779:-STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.9983e-030.2059image
chr10:28525066-28525791:-STADGSVA_HALLMARK_MTORC1_SIGNALINGEER7.9140e-060.2389image
ENSG00000254635.4,WAC-AS1TGCTGSVA_HALLMARK_GLYCOLYSISEAG5.2642e-03-0.2643image
ENSG00000254635.4,WAC-AS1THCAGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG4.5157e-03-0.1316image
chr10:28525066-28525791:-THCAGSVA_HALLMARK_UV_RESPONSE_DNEER1.1309e-04-0.1802image
chr10:28522999-28523779:-UCECGSVA_HALLMARK_PEROXISOMEEER1.5570e-02-0.3371image
ENSG00000254635.4,WAC-AS1UCECGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG1.4698e-040.3154image
chr10:28525066-28525791:-UCECGSVA_HALLMARK_UV_RESPONSE_DNEER4.6010e-030.2461image
chr10:28525066-28525791:-UCSGSVA_HALLMARK_NOTCH_SIGNALINGEER1.8269e-020.3326image
ENSG00000254635.4,WAC-AS1UCSGSVA_HALLMARK_E2F_TARGETSEAG4.0593e-03-0.3883image
ENSG00000254635.4,WAC-AS1UVMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG4.8140e-03-0.3888image


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7. Enriched editing regions and drugs for WAC-AS1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr10:28522999-28523779:-BLCACMKEER2.0468e-03-0.2701image
chr10:28525066-28525791:-BLCACamptothecinEER3.7268e-03-0.1576image
ENSG00000254635.4,WAC-AS1BLCAGefitinibEAG3.6867e-040.1864image
chr10:28522999-28523779:-BRCAAxitinibEER4.4517e-030.1407image
chr10:28525066-28525791:-BRCABryostatin.1EER1.4572e-04-0.1223image
ENSG00000254635.4,WAC-AS1BRCAImatinibEAG1.5039e-04-0.1200image
ENSG00000254635.4,WAC-AS1CESCAZD6482EAG1.3119e-05-0.2842image
ENSG00000254635.4,WAC-AS1CHOLJNK.9LEAG9.2461e-030.4829image
chr10:28522999-28523779:-COADGW843682XEER2.0916e-040.5539image
ENSG00000254635.4,WAC-AS1COADJNK.Inhibitor.VIIIEAG6.6084e-03-0.2094image
chr10:28525066-28525791:-ESCAKU.55933EER1.3495e-04-0.3038image
ENSG00000254635.4,WAC-AS1ESCAABT.263EAG4.2386e-05-0.3226image
chr10:28522999-28523779:-ESCAAICAREER3.0873e-02-0.2079image
ENSG00000254635.4,WAC-AS1GBMCyclopamineEAG6.4690e-030.2395image
chr10:28522999-28523779:-GBMBMS.708163EER3.4738e-03-0.2970image
chr10:28522999-28523779:-HNSCCEP.701EER1.8868e-04-0.2623image
chr10:28525066-28525791:-HNSCFH535EER1.1570e-020.1412image
ENSG00000254635.4,WAC-AS1HNSCAZD6244EAG6.4161e-060.2306image
ENSG00000254635.4,WAC-AS1KICHGNF.2EAG7.9019e-040.4511image
ENSG00000254635.4,WAC-AS1KIRCDasatinibEAG2.0568e-030.1663image
chr10:28525066-28525791:-KIRCEmbelinEER1.2541e-030.1769image
chr10:28522999-28523779:-KIRCCisplatinEER1.1960e-04-0.3274image
ENSG00000254635.4,WAC-AS1KIRPCGP.082996EAG9.3450e-050.2381image
chr10:28525066-28525791:-KIRPA.443654EER7.5302e-050.2487image
chr10:28525066-28525791:-LGGFH535EER1.1623e-07-0.2352image
ENSG00000254635.4,WAC-AS1LGGFH535EAG1.3364e-05-0.1930image
ENSG00000254635.4,WAC-AS1LIHCDoxorubicinEAG4.3219e-09-0.3308image
chr10:28522999-28523779:-LIHCAZD6244EER4.7315e-06-0.2894image
chr10:28525066-28525791:-LIHCFTI.277EER2.4639e-030.2250image
chr10:28522999-28523779:-LUADBX.795EER2.0820e-020.1587image
chr10:28525066-28525791:-LUADKU.55933EER2.4548e-03-0.1623image
ENSG00000254635.4,WAC-AS1LUADCGP.60474EAG3.6082e-070.2441image
chr10:28522999-28523779:-LUSCAKT.inhibitor.VIIIEER2.3355e-030.2190image
chr10:28525066-28525791:-LUSCCGP.60474EER1.0108e-02-0.1332image
ENSG00000254635.4,WAC-AS1LUSCImatinibEAG4.0723e-03-0.1418image
ENSG00000254635.4,WAC-AS1MESOAKT.inhibitor.VIIIEAG3.0339e-02-0.2537image
ENSG00000254635.4,WAC-AS1OVCHIR.99021EAG3.4820e-05-0.2447image
chr10:28525066-28525791:-OVAZD6482EER2.9895e-080.3353image
chr10:28522999-28523779:-OVAZ628EER5.2011e-04-0.2276image
chr10:28525066-28525791:-PAADJNJ.26854165EER4.2904e-040.2804image
ENSG00000254635.4,WAC-AS1PAADAZD6244EAG2.9604e-030.2314image
ENSG00000254635.4,WAC-AS1PCPGCGP.60474EAG2.5586e-040.3054image
ENSG00000254635.4,WAC-AS1PRADEpothilone.BEAG6.8742e-03-0.1259image
ENSG00000254635.4,WAC-AS1READCGP.082996EAG6.3786e-05-0.4685image
chr10:28525066-28525791:-SARCDasatinibEER5.4393e-03-0.1964image
ENSG00000254635.4,WAC-AS1SARCLapatinibEAG1.5750e-04-0.2527image
chr10:28522999-28523779:-SKCMAUY922EER2.0314e-05-0.3769image
ENSG00000254635.4,WAC-AS1SKCMGNF.2EAG3.2508e-040.1924image
chr10:28522999-28523779:-STADCisplatinEER8.1971e-03-0.1766image
ENSG00000254635.4,WAC-AS1STADCMKEAG3.5155e-030.1558image
chr10:28525066-28525791:-STADAS601245EER1.4056e-030.1720image
ENSG00000254635.4,WAC-AS1TGCTAICAREAG1.1460e-02-0.2403image
ENSG00000254635.4,WAC-AS1THCAKU.55933EAG7.3909e-030.1242image
chr10:28525066-28525791:-THCABexaroteneEER1.4514e-040.1774image
ENSG00000254635.4,WAC-AS1THYMCMKEAG7.0927e-030.2520image
chr10:28522999-28523779:-UCECDocetaxelEER4.7668e-030.3892image
chr10:28525066-28525791:-UCECBIRB.0796EER1.4342e-030.2757image
ENSG00000254635.4,WAC-AS1UCECBMS.754807EAG1.3352e-03-0.2686image
chr10:28525066-28525791:-UCSBIBW2992EER1.9206e-03-0.4282image
ENSG00000254635.4,WAC-AS1UCSAMG.706EAG3.2508e-030.3970image
ENSG00000254635.4,WAC-AS1UVMBMS.536924EAG1.0094e-030.4469image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType