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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: SLC25A43 (ImmuneEditome ID:203427)

1. Gene summary of enriched editing regions for SLC25A43

check button Gene summary
Gene informationGene symbol

SLC25A43

Gene ID

203427

GeneSynonyms-
GeneCytomap

Xq24

GeneTypeprotein-coding
GeneDescriptionsolute carrier family 25 member 43
GeneModificationdate20230329
UniprotIDQ8WUT9
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chrX:119415848-119416453:+ENST00000484058.1ENSG00000077713.17SLC25A43ncRNA_intronicAluJb,AluSx3,L1ME4achrX:119415848-119416453:+.alignment
chrX:119415848-119416453:+ENST00000488158.4ENSG00000077713.17SLC25A43ncRNA_intronicAluJb,AluSx3,L1ME4achrX:119415848-119416453:+.alignment
chrX:119415848-119416453:+ENST00000493093.4ENSG00000077713.17SLC25A43ncRNA_intronicAluJb,AluSx3,L1ME4achrX:119415848-119416453:+.alignment
chrX:119420313-119421082:+ENST00000484058.1ENSG00000077713.17SLC25A43ncRNA_intronicAluJr,AluSx1chrX:119420313-119421082:+.alignment
chrX:119420313-119421082:+ENST00000488158.4ENSG00000077713.17SLC25A43ncRNA_intronicAluJr,AluSx1chrX:119420313-119421082:+.alignment
chrX:119420313-119421082:+ENST00000493093.4ENSG00000077713.17SLC25A43ncRNA_intronicAluJr,AluSx1chrX:119420313-119421082:+.alignment
chrX:119431268-119432717:+ENST00000484058.1ENSG00000077713.17SLC25A43ncRNA_intronicAluSz,L1MC5,A-rich,AluSx1chrX:119431268-119432717:+.alignment
chrX:119431268-119432717:+ENST00000488158.4ENSG00000077713.17SLC25A43ncRNA_intronicAluSz,L1MC5,A-rich,AluSx1chrX:119431268-119432717:+.alignment
chrX:119431268-119432717:+ENST00000493093.4ENSG00000077713.17SLC25A43ncRNA_intronicAluSz,L1MC5,A-rich,AluSx1chrX:119431268-119432717:+.alignment
chrX:119444582-119446051:+ENST00000484058.1ENSG00000077713.17SLC25A43ncRNA_intronicAluSq2,AluSx,AluSz6,MIRb,MIR3chrX:119444582-119446051:+.alignment
chrX:119444582-119446051:+ENST00000488158.4ENSG00000077713.17SLC25A43ncRNA_intronicAluSq2,AluSx,AluSz6,MIRb,MIR3chrX:119444582-119446051:+.alignment
chrX:119444582-119446051:+ENST00000493093.4ENSG00000077713.17SLC25A43ncRNA_intronicAluSq2,AluSx,AluSz6,MIRb,MIR3chrX:119444582-119446051:+.alignment
chrX:119447176-119447486:+ENST00000484058.1ENSG00000077713.17SLC25A43ncRNA_intronicAluSx1,L2a,AluJrchrX:119447176-119447486:+.alignment
chrX:119447176-119447486:+ENST00000488158.4ENSG00000077713.17SLC25A43ncRNA_intronicAluSx1,L2a,AluJrchrX:119447176-119447486:+.alignment
chrX:119447176-119447486:+ENST00000493093.4ENSG00000077713.17SLC25A43ncRNA_intronicAluSx1,L2a,AluJrchrX:119447176-119447486:+.alignment
chrX:119448707-119450540:+ENST00000484058.1ENSG00000077713.17SLC25A43ncRNA_intronicL2b,MIRb,(AAAAG)n,L2a,AluJb,AluSxchrX:119448707-119450540:+.alignment
chrX:119448707-119450540:+ENST00000488158.4ENSG00000077713.17SLC25A43ncRNA_intronicL2b,MIRb,(AAAAG)n,L2a,AluJb,AluSxchrX:119448707-119450540:+.alignment
chrX:119448707-119450540:+ENST00000493093.4ENSG00000077713.17SLC25A43ncRNA_intronicL2b,MIRb,(AAAAG)n,L2a,AluJb,AluSxchrX:119448707-119450540:+.alignment


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2. Tumor-specific enriched editing regions for SLC25A43


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000077713.17,SLC25A43STADPathEAG5.0244e-032.3795e-02-0.1749image
ENSG00000077713.17,SLC25A43THCAPathEAG2.7298e-024.8945e-020.1794image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for SLC25A43


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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4. Enriched editing regions and immune related splicing for SLC25A43


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000077713.17,SLC25A43
ESCAEAGA5ENSG00000165219.17chr9125323797:125323923:125321432:125321499:125321432:1253215620.42561.4498e-023.0536e-060.4196imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;MBNL2;MOV10;MSI1;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;RBM47;RNF219;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZNF184GAPVD1EosinophilsGSVA_HALLMARK_FATTY_ACID_METABOLISM
ENSG00000077713.17,SLC25A43
ESCAEAGIRENSG00000144381.12chr2197495050:197495364:197497139:197497392-0.20813.7249e-022.4535e-07-0.4784imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CBX7;CELF2;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;METTL14;MOV10;MSI1;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;RBM47;RNF219;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZNF184HSPD1GSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSE

More results



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5. Enriched editing regions and immune infiltration for SLC25A43


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000077713.17,SLC25A43BLCAEAGMacrophages_M29.5279e-030.4207image
ENSG00000077713.17,SLC25A43COADEAGT_cells_regulatory_(Tregs)4.5145e-03-0.5941image
chrX:119431268-119432717:+ESCAEERT_cells_regulatory_(Tregs)2.1699e-020.3240image
ENSG00000077713.17,SLC25A43KIRCEAGMacrophages_M01.5332e-030.3404image
ENSG00000077713.17,SLC25A43KIRPEAGMast_cells_resting1.3611e-020.4191image
ENSG00000077713.17,SLC25A43LGGEAGNK_cells_activated2.0189e-050.3111image
ENSG00000077713.17,SLC25A43LIHCEAGT_cells_CD4_memory_resting3.1367e-020.3812image
ENSG00000077713.17,SLC25A43PAADEAGMast_cells_activated1.5422e-040.5401image
ENSG00000077713.17,SLC25A43PCPGEAGNK_cells_resting5.1970e-030.4335image
ENSG00000077713.17,SLC25A43PRADEAGEosinophils8.5786e-110.7121image
ENSG00000077713.17,SLC25A43SARCEAGT_cells_CD4_memory_activated2.2672e-020.2530image
chrX:119415848-119416453:+STADEERPlasma_cells4.7142e-02-0.2531image
chrX:119420313-119421082:+STADEERDendritic_cells_activated1.2073e-020.3050image
chrX:119444582-119446051:+STADEERMonocytes3.1894e-020.3687image
chrX:119448707-119450540:+STADEERDendritic_cells_activated3.1347e-040.4496image
ENSG00000077713.17,SLC25A43STADEAGDendritic_cells_activated2.8399e-030.2250image
ENSG00000077713.17,SLC25A43THCAEAGEosinophils3.2548e-060.4103image
ENSG00000077713.17,SLC25A43UCECEAGT_cells_regulatory_(Tregs)9.0253e-030.4542image


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6. Enriched editing regions and immune gene sets for SLC25A43


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000077713.17,SLC25A43PRADEAG6.3939e-05-0.48533.6506e-02-0.26623.5058e-05-0.50001.2581e-03-0.4005image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000077713.17,SLC25A43BLCAGSVA_HALLMARK_HEME_METABOLISMEAG7.0758e-04-0.5317image
ENSG00000077713.17,SLC25A43BRCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.1104e-03-0.1780image
ENSG00000077713.17,SLC25A43COADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG5.1283e-05-0.7662image
ENSG00000077713.17,SLC25A43ESCAGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG1.7431e-020.2214image
chrX:119444582-119446051:+ESCAGSVA_HALLMARK_GLYCOLYSISEER2.9477e-020.4869image
chrX:119431268-119432717:+ESCAGSVA_HALLMARK_MTORC1_SIGNALINGEER2.0555e-02-0.3268image
ENSG00000077713.17,SLC25A43GBMGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG7.6247e-03-0.2859image
ENSG00000077713.17,SLC25A43KIRCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.2025e-03-0.3180image
ENSG00000077713.17,SLC25A43LAMLGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG4.7662e-04-0.3534image
ENSG00000077713.17,SLC25A43LGGGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG2.5643e-06-0.3414image
ENSG00000077713.17,SLC25A43LUADGSVA_HALLMARK_HEME_METABOLISMEAG3.7938e-03-0.3596image
ENSG00000077713.17,SLC25A43LUSCGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG8.7434e-03-0.3670image
ENSG00000077713.17,SLC25A43OVGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG5.0349e-03-0.2855image
ENSG00000077713.17,SLC25A43PAADGSVA_HALLMARK_G2M_CHECKPOINTEAG1.7267e-02-0.3573image
ENSG00000077713.17,SLC25A43PCPGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG2.5639e-020.3526image
ENSG00000077713.17,SLC25A43PRADGSVA_HALLMARK_HEME_METABOLISMEAG1.5107e-07-0.6089image
ENSG00000077713.17,SLC25A43SARCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.4765e-020.2349image
ENSG00000077713.17,SLC25A43SKCMGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.8025e-03-0.5227image
chrX:119415848-119416453:+STADGSVA_HALLMARK_GLYCOLYSISEER1.3913e-020.3109image
chrX:119448707-119450540:+STADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER1.9775e-030.3915image
ENSG00000077713.17,SLC25A43STADGSVA_HALLMARK_MYOGENESISEAG9.4538e-05-0.2916image
ENSG00000077713.17,SLC25A43THCAGSVA_HALLMARK_ANGIOGENESISEAG4.3633e-03-0.2585image
ENSG00000077713.17,SLC25A43UCECGSVA_HALLMARK_G2M_CHECKPOINTEAG3.0208e-03-0.5076image


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7. Enriched editing regions and drugs for SLC25A43


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000077713.17,SLC25A43BLCALenalidomideEAG6.9946e-04-0.5321image
ENSG00000077713.17,SLC25A43BRCAGefitinibEAG2.6281e-02-0.1352image
ENSG00000077713.17,SLC25A43CESCATRAEAG1.8948e-040.6583image
ENSG00000077713.17,SLC25A43COADBMS.708163EAG6.8462e-04-0.6806image
ENSG00000077713.17,SLC25A43ESCAAZD6244EAG3.9124e-03-0.2670image
chrX:119420313-119421082:+ESCAAZD6244EER4.2322e-03-0.3798image
chrX:119444582-119446051:+ESCAAZD6244EER4.6799e-02-0.4494image
chrX:119431268-119432717:+ESCACCT007093EER1.5183e-02-0.3416image
ENSG00000077713.17,SLC25A43GBMAMG.706EAG8.0641e-03-0.2839image
ENSG00000077713.17,SLC25A43KIRCAZ628EAG2.4499e-05-0.4430image
ENSG00000077713.17,SLC25A43KIRPJNK.9LEAG2.4390e-020.3854image
ENSG00000077713.17,SLC25A43LAMLBortezomibEAG1.1559e-020.2595image
ENSG00000077713.17,SLC25A43LGGCMKEAG3.5153e-050.3024image
ENSG00000077713.17,SLC25A43LIHCGSK269962AEAG1.5546e-02-0.4242image
ENSG00000077713.17,SLC25A43LUADCMKEAG2.1724e-02-0.2888image
ENSG00000077713.17,SLC25A43LUSCImatinibEAG4.8339e-020.2807image
ENSG00000077713.17,SLC25A43OVA.443654EAG1.9509e-02-0.2393image
ENSG00000077713.17,SLC25A43PAADAICAREAG7.1548e-060.6201image
ENSG00000077713.17,SLC25A43PCPGCEP.701EAG3.3551e-02-0.3368image
ENSG00000077713.17,SLC25A43PRADATRAEAG7.2998e-05-0.4855image
ENSG00000077713.17,SLC25A43SARCABT.263EAG3.2984e-07-0.5315image
ENSG00000077713.17,SLC25A43SKCMErlotinibEAG2.7184e-03-0.5051image
chrX:119420313-119421082:+STADAMG.706EER1.4280e-02-0.2981image
chrX:119415848-119416453:+STADABT.263EER1.5388e-030.3939image
chrX:119444582-119446051:+STADGSK.650394EER1.1746e-030.5329image
chrX:119448707-119450540:+STADFTI.277EER3.4534e-03-0.3717image
ENSG00000077713.17,SLC25A43STADDasatinibEAG1.5075e-040.2850image
ENSG00000077713.17,SLC25A43THCABexaroteneEAG4.7459e-030.2561image
ENSG00000077713.17,SLC25A43UCECCEP.701EAG5.7609e-05-0.6495image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType