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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: CCDC125 (ImmuneEditome ID:202243)

1. Gene summary of enriched editing regions for CCDC125

check button Gene summary
Gene informationGene symbol

CCDC125

Gene ID

202243

GeneSynonymsKENAE
GeneCytomap

5q13.2

GeneTypeprotein-coding
GeneDescriptioncoiled-coil domain-containing protein 125
GeneModificationdate20230517
UniprotIDF8W912;Q86Z20
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr5:69280880-69282563:-ENST00000460090.4ENSG00000183323.11CCDC125ncRNA_exonic(TGTAA)n,AluSp,AluJb,AluJr,AluSz,(AC)nchr5:69280880-69282563:-.alignment
chr5:69289731-69290843:-ENST00000460090.4ENSG00000183323.11CCDC125ncRNA_intronicAluSx1,AluJo,AluSx,L4_B_Mam,(TTA)nchr5:69289731-69290843:-.alignment
chr5:69292943-69293575:-ENST00000460090.4ENSG00000183323.11CCDC125ncRNA_intronicAluJb,AluSg7,AluSxchr5:69292943-69293575:-.alignment
chr5:69311491-69312051:-ENST00000460090.4ENSG00000183323.11CCDC125ncRNA_intronicAluSc5,AluSz,MER57C2,AluSxchr5:69311491-69312051:-.alignment
chr5:69311491-69312051:-ENST00000512045.4ENSG00000183323.11CCDC125ncRNA_intronicAluSc5,AluSz,MER57C2,AluSxchr5:69311491-69312051:-.alignment
chr5:69314316-69316834:-ENST00000460090.4ENSG00000183323.11CCDC125ncRNA_intronicMLT1D,(A)n,AluSq2,AluSz,7SLRNA,AluJr4,AluJr,AluSx,AluSz6chr5:69314316-69316834:-.alignment
chr5:69314316-69316834:-ENST00000512045.4ENSG00000183323.11CCDC125ncRNA_intronicMLT1D,(A)n,AluSq2,AluSz,7SLRNA,AluJr4,AluJr,AluSx,AluSz6chr5:69314316-69316834:-.alignment
chr5:69314316-69316834:-ENST00000513172.1ENSG00000183323.11CCDC125ncRNA_intronicMLT1D,(A)n,AluSq2,AluSz,7SLRNA,AluJr4,AluJr,AluSx,AluSz6chr5:69314316-69316834:-.alignment
chr5:69317906-69320070:-ENST00000460090.4ENSG00000183323.11CCDC125ncRNA_intronicAluSx1,AluY,L2a,AluSg,AluSz,AluSz6,AluJr4chr5:69317906-69320070:-.alignment
chr5:69317906-69320070:-ENST00000512045.4ENSG00000183323.11CCDC125ncRNA_intronicAluSx1,AluY,L2a,AluSg,AluSz,AluSz6,AluJr4chr5:69317906-69320070:-.alignment
chr5:69317906-69320070:-ENST00000513172.1ENSG00000183323.11CCDC125ncRNA_intronicAluSx1,AluY,L2a,AluSg,AluSz,AluSz6,AluJr4chr5:69317906-69320070:-.alignment


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2. Tumor-specific enriched editing regions for CCDC125


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr5:69280880-69282563:-BRCAEER2.6860e-05image
ENSG00000183323.11,CCDC125BRCAEAG2.6524e-05image
chr5:69280880-69282563:-HNSCEER4.6939e-05image
ENSG00000183323.11,CCDC125HNSCEAG4.6939e-05image
chr5:69280880-69282563:-LUSCEER1.5901e-02image
ENSG00000183323.11,CCDC125LUSCEAG1.5960e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000183323.11,CCDC125PAADPathEAG3.5096e-021.5405e-020.2264image
chr5:69280880-69282563:-PAADPathEER3.5096e-021.5405e-020.2264image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr5:69280880-69282563:-LGGEER3.7275e-021.1907e-031.5192e+02image
ENSG00000183323.11,CCDC125LGGEAG3.9293e-021.2792e-031.4177e+02image

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3. Enriched editing regions and immune related genes for CCDC125


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr5:69280880-69282563:-GBMEERENSG00000197291,RAMP2-AS10.39991.2872e-033.6297e-060.4054imageNNNAT_cells_follicular_helperGSVA_HALLMARK_COAGULATION
chr5:69280880-69282563:-GBMEERENSG00000138074,SLC5A60.38682.1137e-031.7017e-070.4522imageNNNAMonocytesGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr5:69280880-69282563:-GBMEERENSG00000198393,ZNF260.38722.3650e-034.9773e-060.4001imageNNNAT_cells_follicular_helperGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr5:69280880-69282563:-GBMEERENSG00000231160,KLF3-AS10.38602.4048e-037.3700e-070.4307imageNNNAT_cells_follicular_helperGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr5:69280880-69282563:-GBMEERENSG00000214578,HMGN2P150.37453.2061e-031.2290e-060.4228imageNNNAT_cells_follicular_helperGSVA_HALLMARK_COAGULATION
chr5:69280880-69282563:-GBMEERENSG00000201772,SNORA5C0.36814.3290e-035.4116e-070.4353imageNNNAMonocytesGSVA_HALLMARK_BILE_ACID_METABOLISM
chr5:69280880-69282563:-GBMEERENSG00000120458,MSANTD20.30912.2808e-022.1944e-060.4136imageNNNAMonocytesGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE

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4. Enriched editing regions and immune related splicing for CCDC125


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr5:69280880-69282563:-
GBMEERIRENSG00000185189.11chr8143837622:143837755:143838679:1438387750.34443.7230e-025.1832e-060.4009imageNNNRBP2MonocytesGSVA_HALLMARK_ADIPOGENESIS
ENSG00000183323.11,CCDC125
GBMEAGIRENSG00000136002.12chr2131040260:131040440:131041229:1310412760.40435.8808e-037.7347e-070.4349imageNACIN1;ADAR;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FBL;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;LIN28;MBNL2;MOV10;NOP56;NOP58;NUMA1;PTBP1;RANGAP1;RBFOX2;RBM10;RBM47;RBM5;RNF219;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIAL1;TROVE2;U2AF2;UPF1;VIM;YTHDF1;ZNF184ARHGEF4MonocytesGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr5:69280880-69282563:-
GBMEERESENSG00000147854.12chr96493825:6493932:6496959:6497103:6497197:64972680.31281.1240e-022.5333e-060.4261imageNNNAMonocytesGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr5:69280880-69282563:-
GBMEERIRENSG00000136002.12chr2131040260:131040440:131041229:1310412760.40435.0539e-037.7347e-070.4349imageNNARHGEF4MonocytesGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000183323.11,CCDC125
GBMEAGA5ENSG00000177728.10chr1775492473:75492742:75491698:75491852:75491698:75492337-0.30394.0624e-023.8991e-05-0.4010imageNACIN1;ADAR;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDF1;ZNF184NAT_cells_follicular_helperGSVA_HALLMARK_HEME_METABOLISM
ENSG00000183323.11,CCDC125
GBMEAGIRENSG00000185189.11chr8143837622:143837755:143838679:1438387750.34444.3032e-025.1832e-060.4009imageNBUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28B;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDF1;YWHAG;ZNF184NRBP2MonocytesGSVA_HALLMARK_ADIPOGENESIS
chr5:69280880-69282563:-
GBMEERIRENSG00000134222.12chr1109282517:109282736:109283062:1092831150.43531.8759e-031.5558e-070.4535imageNNNAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
ENSG00000183323.11,CCDC125
GBMEAGESENSG00000147854.12chr96493825:6493932:6496959:6497103:6497197:64972680.31281.3180e-022.5333e-060.4261imageNACIN1;ADAR;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDF1;YWHAG;ZNF184NAMonocytesGSVA_HALLMARK_XENOBIOTIC_METABOLISM
ENSG00000183323.11,CCDC125
GBMEAGIRENSG00000115970.14chr243291695:43291768:43292103:432922220.35752.5772e-023.7471e-060.4064imageNACIN1;ADAR;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;SAFB2;SF3A3;SF3B4;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDF1NAT_cells_follicular_helperGSVA_HALLMARK_ADIPOGENESIS
chr5:69280880-69282563:-
GBMEERIRENSG00000115970.14chr243291695:43291768:43292103:432922220.35752.2094e-023.7471e-060.4064imageNNNAT_cells_follicular_helperGSVA_HALLMARK_ADIPOGENESIS

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5. Enriched editing regions and immune infiltration for CCDC125


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr5:69280880-69282563:-ACCEERPlasma_cells3.1152e-02-0.3758image
ENSG00000183323.11,CCDC125ACCEAGPlasma_cells3.8316e-02-0.3622image
chr5:69280880-69282563:-BLCAEERB_cells_memory2.5475e-040.2395image
ENSG00000183323.11,CCDC125BLCAEAGB_cells_memory2.9514e-040.2356image
chr5:69280880-69282563:-BRCAEERT_cells_regulatory_(Tregs)3.0524e-05-0.1320image
chr5:69311491-69312051:-BRCAEERMonocytes4.0592e-02-0.4300image
chr5:69314316-69316834:-BRCAEERT_cells_CD4_memory_resting1.4688e-02-0.3879image
ENSG00000183323.11,CCDC125BRCAEAGT_cells_regulatory_(Tregs)3.4579e-05-0.1306image
chr5:69280880-69282563:-CESCEERT_cells_CD4_memory_resting6.7530e-030.1944image
ENSG00000183323.11,CCDC125CESCEAGT_cells_CD4_memory_resting6.0914e-030.1963image
chr5:69280880-69282563:-CHOLEERMacrophages_M04.8583e-020.3760image
ENSG00000183323.11,CCDC125CHOLEAGMacrophages_M04.8583e-020.3760image
chr5:69280880-69282563:-COADEERT_cells_gamma_delta1.5291e-020.1776image
ENSG00000183323.11,CCDC125COADEAGEosinophils1.1698e-040.2766image
chr5:69280880-69282563:-ESCAEEREosinophils4.7986e-02-0.1738image
ENSG00000183323.11,CCDC125ESCAEAGEosinophils3.1070e-02-0.1885image
chr5:69280880-69282563:-GBMEERB_cells_memory7.4089e-04-0.3014image
ENSG00000183323.11,CCDC125GBMEAGB_cells_memory7.4089e-04-0.3014image
chr5:69280880-69282563:-HNSCEERT_cells_CD4_naive2.3439e-02-0.1661image
ENSG00000183323.11,CCDC125HNSCEAGT_cells_CD4_naive2.3439e-02-0.1661image
chr5:69280880-69282563:-KIRCEERMacrophages_M21.8817e-040.2296image
ENSG00000183323.11,CCDC125KIRCEAGMacrophages_M22.0391e-040.2280image
chr5:69280880-69282563:-KIRPEERMast_cells_resting2.1515e-030.2564image
ENSG00000183323.11,CCDC125KIRPEAGMast_cells_resting2.1515e-030.2564image
chr5:69280880-69282563:-LGGEERT_cells_CD81.3614e-020.1862image
ENSG00000183323.11,CCDC125LGGEAGT_cells_CD82.1907e-020.1732image
chr5:69280880-69282563:-LUADEERMacrophages_M01.5241e-04-0.1885image
ENSG00000183323.11,CCDC125LUADEAGMacrophages_M02.4493e-04-0.1820image
chr5:69280880-69282563:-LUSCEERMast_cells_resting1.5581e-030.1999image
ENSG00000183323.11,CCDC125LUSCEAGMast_cells_resting1.5491e-030.2000image
ENSG00000183323.11,CCDC125MESOEAGB_cells_memory3.1728e-040.5127image
chr5:69280880-69282563:-PAADEERT_cells_CD4_memory_resting1.6093e-020.2240image
ENSG00000183323.11,CCDC125PAADEAGT_cells_CD4_memory_resting1.6093e-020.2240image
chr5:69280880-69282563:-PRADEERT_cells_regulatory_(Tregs)1.1903e-04-0.1790image
ENSG00000183323.11,CCDC125PRADEAGMast_cells_activated8.2652e-040.1542image
chr5:69280880-69282563:-READEERT_cells_CD4_naive9.9969e-040.3988image
ENSG00000183323.11,CCDC125READEAGT_cells_CD4_naive9.9295e-040.3990image
ENSG00000183323.11,CCDC125SARCEAGT_cells_CD4_memory_resting1.4346e-040.3766image
chr5:69280880-69282563:-SKCMEERT_cells_CD81.6076e-05-0.3089image
ENSG00000183323.11,CCDC125SKCMEAGT_cells_CD81.6076e-05-0.3089image
chr5:69289731-69290843:-STADEERT_cells_CD85.1891e-030.4389image
chr5:69314316-69316834:-STADEERT_cells_regulatory_(Tregs)1.6960e-02-0.3467image
chr5:69317906-69320070:-STADEERB_cells_memory3.5019e-050.4558image
chr5:69280880-69282563:-TGCTEERNK_cells_activated7.8434e-03-0.3110image
ENSG00000183323.11,CCDC125TGCTEAGNK_cells_activated7.8434e-03-0.3110image
chr5:69280880-69282563:-THCAEERDendritic_cells_resting1.7938e-03-0.1566image
ENSG00000183323.11,CCDC125THCAEAGDendritic_cells_resting1.1789e-03-0.1622image
chr5:69280880-69282563:-THYMEERMast_cells_activated1.5695e-020.3215image
ENSG00000183323.11,CCDC125THYMEAGMast_cells_activated1.7192e-020.3145image
chr5:69280880-69282563:-UCECEERDendritic_cells_activated4.6096e-02-0.1753image
ENSG00000183323.11,CCDC125UCECEAGDendritic_cells_activated3.5067e-02-0.1836image
chr5:69280880-69282563:-UCSEERNeutrophils3.3073e-020.3968image
ENSG00000183323.11,CCDC125UCSEAGNeutrophils3.3073e-020.3968image


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6. Enriched editing regions and immune gene sets for CCDC125


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr5:69280880-69282563:-BLCAEER3.8120e-04-0.23285.7268e-03-0.18211.0077e-04-0.25419.1384e-04-0.2177image
ENSG00000183323.11,CCDC125BLCAEAG3.3367e-04-0.23356.3667e-03-0.17861.0325e-04-0.25226.6247e-04-0.2219image
chr5:69280880-69282563:-LUADEER4.2643e-04-0.17566.1620e-04-0.17071.4748e-03-0.15871.9069e-02-0.1173image
ENSG00000183323.11,CCDC125LUADEAG2.1073e-04-0.18384.4977e-04-0.17429.4782e-04-0.16431.0220e-02-0.1280image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000183323.11,CCDC125ACCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG1.1563e-020.4343image
chr5:69280880-69282563:-ACCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER1.1891e-020.4328image
ENSG00000183323.11,CCDC125BLCAGSVA_HALLMARK_COMPLEMENTEAG3.9702e-07-0.3255image
chr5:69280880-69282563:-BLCAGSVA_HALLMARK_COMPLEMENTEER5.9925e-07-0.3227image
ENSG00000183323.11,CCDC125BRCAGSVA_HALLMARK_UV_RESPONSE_DNEAG1.7066e-070.1644image
chr5:69280880-69282563:-BRCAGSVA_HALLMARK_UV_RESPONSE_DNEER4.0703e-070.1600image
chr5:69314316-69316834:-BRCAGSVA_HALLMARK_ADIPOGENESISEER9.0084e-050.5856image
chr5:69311491-69312051:-BRCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER2.6587e-020.4617image
chr5:69280880-69282563:-CESCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER8.7037e-05-0.2787image
ENSG00000183323.11,CCDC125CESCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG7.5368e-05-0.2803image
chr5:69280880-69282563:-CHOLGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER2.7571e-03-0.5442image
ENSG00000183323.11,CCDC125CHOLGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG2.7571e-03-0.5442image
chr5:69280880-69282563:-COADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.0004e-02-0.1884image
ENSG00000183323.11,CCDC125COADGSVA_HALLMARK_P53_PATHWAYEAG2.1252e-03-0.2221image
chr5:69280880-69282563:-GBMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER2.1515e-03-0.2752image
ENSG00000183323.11,CCDC125GBMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG2.1515e-03-0.2752image
ENSG00000183323.11,CCDC125HNSCGSVA_HALLMARK_MITOTIC_SPINDLEEAG9.5559e-060.3183image
chr5:69280880-69282563:-HNSCGSVA_HALLMARK_MITOTIC_SPINDLEEER9.5559e-060.3183image
ENSG00000183323.11,CCDC125KIRCGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.4091e-020.1518image
chr5:69280880-69282563:-KIRCGSVA_HALLMARK_PROTEIN_SECRETIONEER2.2964e-030.1883image
ENSG00000183323.11,CCDC125LGGGSVA_HALLMARK_ADIPOGENESISEAG1.0110e-02-0.1940image
chr5:69280880-69282563:-LGGGSVA_HALLMARK_ADIPOGENESISEER1.3782e-02-0.1859image
chr5:69280880-69282563:-LIHCGSVA_HALLMARK_PROTEIN_SECRETIONEER7.3414e-080.2949image
ENSG00000183323.11,CCDC125LIHCGSVA_HALLMARK_PROTEIN_SECRETIONEAG7.3414e-080.2949image
ENSG00000183323.11,CCDC125LUADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG8.9689e-040.1650image
chr5:69280880-69282563:-LUADGSVA_HALLMARK_BILE_ACID_METABOLISMEER2.3324e-040.1832image
chr5:69280880-69282563:-LUSCGSVA_HALLMARK_HEME_METABOLISMEER4.7499e-040.2203image
ENSG00000183323.11,CCDC125LUSCGSVA_HALLMARK_HEME_METABOLISMEAG4.9123e-040.2197image
ENSG00000183323.11,CCDC125MESOGSVA_HALLMARK_UV_RESPONSE_UPEAG2.8403e-02-0.3269image
chr5:69280880-69282563:-OVGSVA_HALLMARK_UV_RESPONSE_DNEER4.0850e-040.2395image
ENSG00000183323.11,CCDC125OVGSVA_HALLMARK_UV_RESPONSE_DNEAG1.7266e-030.2106image
chr5:69280880-69282563:-PAADGSVA_HALLMARK_UV_RESPONSE_UPEER1.9054e-02-0.2184image
ENSG00000183323.11,CCDC125PAADGSVA_HALLMARK_UV_RESPONSE_UPEAG1.9054e-02-0.2184image
ENSG00000183323.11,CCDC125PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEAG6.0222e-030.2271image
chr5:69280880-69282563:-PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEER6.0222e-030.2271image
chr5:69280880-69282563:-PRADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER2.7619e-02-0.1030image
chr5:69292943-69293575:-PRADGSVA_HALLMARK_G2M_CHECKPOINTEER1.8278e-020.4592image
ENSG00000183323.11,CCDC125PRADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG2.4042e-02-0.1044image
ENSG00000183323.11,CCDC125READGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG3.3310e-02-0.2644image
chr5:69280880-69282563:-READGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER3.3906e-02-0.2635image
ENSG00000183323.11,CCDC125SARCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.7817e-03-0.3133image
chr5:69280880-69282563:-SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.9994e-05-0.2913image
ENSG00000183323.11,CCDC125SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.9994e-05-0.2913image
ENSG00000183323.11,CCDC125STADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.3981e-020.1437image
chr5:69317906-69320070:-STADGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER4.0560e-040.3955image
chr5:69289731-69290843:-STADGSVA_HALLMARK_UV_RESPONSE_UPEER4.5600e-020.3220image
chr5:69314316-69316834:-STADGSVA_HALLMARK_MYC_TARGETS_V1EER1.4285e-020.3552image
ENSG00000183323.11,CCDC125THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG4.0062e-06-0.2291image
chr5:69280880-69282563:-THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER1.7345e-06-0.2379image
chr5:69280880-69282563:-THYMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER4.0325e-02-0.2749image
ENSG00000183323.11,CCDC125THYMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG4.9970e-02-0.2609image
ENSG00000183323.11,CCDC125UCECGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.4821e-020.2117image
chr5:69280880-69282563:-UCECGSVA_HALLMARK_PROTEIN_SECRETIONEER4.1159e-030.2500image
ENSG00000183323.11,CCDC125UCSGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.3494e-02-0.4534image
chr5:69280880-69282563:-UCSGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER1.3494e-02-0.4534image


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7. Enriched editing regions and drugs for CCDC125


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr5:69280880-69282563:-ACCAKT.inhibitor.VIIIEER1.3072e-02-0.4275image
ENSG00000183323.11,CCDC125ACCAKT.inhibitor.VIIIEAG1.4180e-02-0.4230image
ENSG00000183323.11,CCDC125BLCACGP.60474EAG7.9652e-080.3435image
chr5:69280880-69282563:-BLCACGP.60474EER1.1457e-070.3416image
ENSG00000183323.11,CCDC125BRCACCT007093EAG1.0340e-09-0.1915image
chr5:69314316-69316834:-BRCAABT.888EER3.6165e-040.5424image
chr5:69280880-69282563:-BRCACCT007093EER1.2393e-09-0.1913image
chr5:69311491-69312051:-BRCAJW.7.52.1EER4.8941e-02-0.4150image
chr5:69280880-69282563:-CESCErlotinibEER7.8931e-070.3466image
ENSG00000183323.11,CCDC125CESCErlotinibEAG6.9177e-070.3474image
chr5:69280880-69282563:-CHOLLFM.A13EER2.4835e-02-0.4232image
ENSG00000183323.11,CCDC125CHOLLFM.A13EAG2.4835e-02-0.4232image
chr5:69280880-69282563:-COADCI.1040EER6.6195e-030.1985image
ENSG00000183323.11,CCDC125COADAZ628EAG5.7270e-040.2482image
chr5:69280880-69282563:-GBMAxitinibEER8.8744e-04-0.2972image
ENSG00000183323.11,CCDC125GBMAxitinibEAG8.8744e-04-0.2972image
ENSG00000183323.11,CCDC125HNSCDocetaxelEAG7.0712e-050.2872image
chr5:69280880-69282563:-HNSCDocetaxelEER7.0712e-050.2872image
ENSG00000183323.11,CCDC125KIRCBMS.536924EAG4.3330e-050.2512image
chr5:69280880-69282563:-KIRCBMS.536924EER4.3425e-050.2512image
chr5:69280880-69282563:-KIRPGW843682XEER1.9778e-030.2584image
ENSG00000183323.11,CCDC125KIRPGW843682XEAG1.9778e-030.2584image
chr5:69280880-69282563:-LAMLGDC0941EER1.1721e-020.3376image
ENSG00000183323.11,CCDC125LAMLGDC0941EAG3.3875e-030.3126image
ENSG00000183323.11,CCDC125LGGJNK.Inhibitor.VIIIEAG3.0442e-04-0.2699image
chr5:69280880-69282563:-LGGJNK.Inhibitor.VIIIEER4.8864e-04-0.2609image
chr5:69280880-69282563:-LIHCErlotinibEER5.1445e-050.2438image
ENSG00000183323.11,CCDC125LIHCErlotinibEAG5.1445e-050.2438image
ENSG00000183323.11,CCDC125LUADGSK269962AEAG2.1623e-070.2557image
chr5:69280880-69282563:-LUADGSK269962AEER5.8676e-070.2476image
ENSG00000183323.11,CCDC125LUSCAS601245EAG3.9718e-02-0.1307image
chr5:69280880-69282563:-LUSCAS601245EER3.9327e-02-0.1310image
ENSG00000183323.11,CCDC125MESOCEP.701EAG7.2337e-030.3951image
ENSG00000183323.11,CCDC125OVCHIR.99021EAG2.6861e-04-0.2439image
chr5:69280880-69282563:-OVGefitinibEER1.3990e-040.2580image
ENSG00000183323.11,CCDC125PAADA.770041EAG1.5877e-020.2254image
chr5:69280880-69282563:-PAADA.770041EER1.5877e-020.2254image
chr5:69280880-69282563:-PCPGBryostatin.1EER2.7267e-030.2472image
ENSG00000183323.11,CCDC125PCPGBryostatin.1EAG2.7267e-030.2472image
chr5:69280880-69282563:-PRADBIRB.0796EER1.0656e-03-0.1526image
ENSG00000183323.11,CCDC125PRADElesclomolEAG1.2800e-04-0.1765image
chr5:69292943-69293575:-PRADGSK269962AEER3.4215e-020.4167image
chr5:69280880-69282563:-READBIRB.0796EER8.8494e-03-0.3222image
ENSG00000183323.11,CCDC125READBIRB.0796EAG8.9256e-03-0.3219image
ENSG00000183323.11,CCDC125SARCCCT007093EAG5.5780e-04-0.3441image
chr5:69280880-69282563:-SKCMAZD6244EER1.0039e-050.3159image
ENSG00000183323.11,CCDC125SKCMAZD6244EAG1.0039e-050.3159image
chr5:69317906-69320070:-STADAP.24534EER2.7011e-05-0.4616image
chr5:69289731-69290843:-STADBleomycinEER1.5837e-02-0.3839image
chr5:69292943-69293575:-STADAZD6244EER2.7319e-020.4501image
ENSG00000183323.11,CCDC125STADBAY.61.3606EAG3.0556e-03-0.1728image
chr5:69280880-69282563:-STADGNF.2EER1.5818e-030.1880image
chr5:69314316-69316834:-STADBI.2536EER5.7483e-040.4836image
chr5:69280880-69282563:-TGCTAG.014699EER2.6055e-02-0.2622image
ENSG00000183323.11,CCDC125TGCTAG.014699EAG2.6055e-02-0.2622image
chr5:69280880-69282563:-THCAKU.55933EER3.9128e-100.3085image
ENSG00000183323.11,CCDC125THCAKU.55933EAG1.9669e-090.2957image
chr5:69280880-69282563:-THYMBIBW2992EER1.1272e-02-0.3363image
ENSG00000183323.11,CCDC125THYMBIBW2992EAG8.6711e-03-0.3446image
ENSG00000183323.11,CCDC125UCECAS601245EAG1.5266e-03-0.2732image
chr5:69280880-69282563:-UCECAS601245EER2.5133e-03-0.2629image
chr5:69280880-69282563:-UCSCGP.082996EER1.5829e-040.6450image
ENSG00000183323.11,CCDC125UCSCGP.082996EAG1.5829e-040.6450image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType