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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: DENND6A (ImmuneEditome ID:201627)

1. Gene summary of enriched editing regions for DENND6A

check button Gene summary
Gene informationGene symbol

DENND6A

Gene ID

201627

GeneSynonymsAFI1A|FAM116A
GeneCytomap

3p14.3

GeneTypeprotein-coding
GeneDescriptionprotein DENND6A|DENN domain-containing protein 6A|DENN/MADD domain containing 6A|family with sequence similarity 116, member A|protein FAM116A
GeneModificationdate20230329
UniprotIDQ8IWF6
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr3:57626416-57627449:-ENST00000311128.8ENSG00000174839.11DENND6AUTR3AluSz,(AAC)n,AluSpchr3:57626416-57627449:-.alignment
chr3:57662280-57662484:-ENST00000487662.1ENSG00000174839.11DENND6AncRNA_intronicAluJbchr3:57662280-57662484:-.alignment
chr3:57673769-57674558:-ENST00000464875.1ENSG00000174839.11DENND6AncRNA_intronicAluSq2,AluSg,AluYcchr3:57673769-57674558:-.alignment
chr3:57677503-57677758:-ENST00000464875.1ENSG00000174839.11DENND6AncRNA_intronicAluJrchr3:57677503-57677758:-.alignment


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2. Tumor-specific enriched editing regions for DENND6A


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr3:57626416-57627449:-BRCAEER1.5454e-15image
ENSG00000174839.11,DENND6ABRCAEAG3.7801e-16image
chr3:57626416-57627449:-LUADEER1.7715e-05image
ENSG00000174839.11,DENND6ALUADEAG2.6337e-06image
chr3:57626416-57627449:-LUSCEER2.0176e-09image
ENSG00000174839.11,DENND6ALUSCEAG1.2822e-09image
chr3:57626416-57627449:-PRADEER8.4441e-04image
ENSG00000174839.11,DENND6APRADEAG1.6714e-04image
chr3:57626416-57627449:-THCAEER4.4888e-09image
ENSG00000174839.11,DENND6ATHCAEAG2.4279e-09image
chr3:57626416-57627449:-UCECEER4.5190e-04image
ENSG00000174839.11,DENND6AUCECEAG1.8947e-04image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr3:57626416-57627449:-KIRCPathEER5.1809e-031.4441e-020.1215image
ENSG00000174839.11,DENND6AKIRCPathEAG6.8109e-031.1228e-020.1248image
chr3:57662280-57662484:-OVCliEER1.2862e-021.2862e-02-0.5455image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr3:57626416-57627449:-LGGEER3.6590e-022.4300e-021.7799e+02image
ENSG00000174839.11,DENND6ALGGEAG3.3225e-023.6713e-021.8210e+01image

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3. Enriched editing regions and immune related genes for DENND6A


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr3:57626416-57627449:-CESCEERENSG00000130303,BST20.36582.0214e-051.7946e-120.4510imageNCNBP;EIF4A3;FAM120A;FMR1;FUS;FXR1;HNRNPA1;HNRNPK;IGF2BP1;IGF2BP2;IGF2BP3;LIN28B;PRPF8;PTBP1;TAF15;TIA1;TIAL1;U2AF2;UPF1BST2B_cells_memoryGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr3:57626416-57627449:-CESCEERENSG00000174744,BRMS10.33849.8544e-051.9325e-100.4115imageNCNBP;DDX54;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;HNRNPA1;HNRNPK;IGF2BP1;IGF2BP2;IGF2BP3;LIN28B;NOP56;NOP58;PRPF8;PTBP1;RBM10;TAF15;TIA1;U2AF2;UPF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr3:57626416-57627449:-CESCEERENSG00000042753,AP2S10.33831.1024e-041.2342e-180.5469imageNCNBP;DDX54;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;HNRNPA1;HNRNPK;IGF2BP1;IGF2BP2;IGF2BP3;LIN28B;NOP56;NOP58;PRPF8;PTBP1;RBM10;RBM47;TAF15;TIA1;U2AF2;UPF1AP2S1T_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr3:57626416-57627449:-CESCEERENSG00000034510,TMSB100.33061.8535e-041.5239e-270.6465imageNCNBP;DDX54;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;HNRNPA1;HNRNPK;IGF2BP1;IGF2BP2;IGF2BP3;LIN28B;NOP56;NOP58;PRPF8;PTBP1;RBM10;RBM47;TAF15;TIA1;TIAL1;U2AF2;UPF1NAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr3:57626416-57627449:-CESCEERENSG00000262814,MRPL120.29631.1061e-037.6204e-160.5071imageNCNBP;DDX54;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;HNRNPA1;HNRNPK;IGF2BP1;IGF2BP2;IGF2BP3;LIN28B;NOP56;NOP58;PRPF8;PTBP1;RBM10;TAF15;TIA1;U2AF2;UPF1NAB_cells_memoryGSVA_HALLMARK_UV_RESPONSE_DN
chr3:57626416-57627449:-CESCEERENSG00000042493,CAPG0.28951.4741e-031.0540e-110.4367imageNEIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;HNRNPA1;HNRNPK;IGF2BP1;IGF2BP2;LIN28B;PRPF8;PTBP1;TAF15;TIAL1;U2AF2;UPF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr3:57626416-57627449:-CESCEERENSG00000204922,UQCC30.27822.5586e-035.3428e-150.4940imageNCNBP;DDX54;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;HNRNPA1;IGF2BP1;IGF2BP2;IGF2BP3;LIN28B;NOP56;NOP58;PRPF8;TAF15;TIAL1;U2AF2;UPF1NAB_cells_memoryGSVA_HALLMARK_UV_RESPONSE_DN
chr3:57626416-57627449:-CESCEERENSG00000175756,AURKAIP10.27333.1051e-033.8097e-130.4631imageNCNBP;DDX54;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;HNRNPA1;HNRNPK;IGF2BP1;IGF2BP2;IGF2BP3;LIN28B;NOP56;NOP58;PRPF8;PTBP1;RBM10;TAF15;TIA1;U2AF2;UPF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr3:57626416-57627449:-CESCEERENSG00000228232,GAPDHP10.25586.7252e-039.2665e-140.4737imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr3:57626416-57627449:-CESCEERENSG00000168894,RNF1810.25337.6578e-031.3379e-160.5184imageNCNBP;DDX54;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;HNRNPA1;HNRNPK;IGF2BP1;IGF2BP2;IGF2BP3;LIN28B;NOP58;PRPF8;PTBP1;RBM10;TAF15;TIA1;TIAL1;U2AF2;UPF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE

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4. Enriched editing regions and immune related splicing for DENND6A


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr3:57626416-57627449:-
CESCEERIRENSG00000152795.13chr482424628:82425667:82426036:82426129-0.35553.0256e-042.9256e-10-0.4077imageNCNBP;DDX54;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;HNRNPA1;HNRNPK;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS3;LIN28B;NOP56;NOP58;PRPF8;PTBP1;RBM10;RBM47;TAF15;TIA1;TIAL1;U2AF2;UPF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
ENSG00000174839.11,DENND6A
CESCEAGIRENSG00000068438.10chrX48482596:48482794:48482985:484830270.32851.3053e-032.4167e-150.4965imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;YTHDF1;ZNF184NAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000174839.11,DENND6A
CESCEAGMEXENSG00000165819.7chr1421499024:21499137:21499305:21499371:21500494:21500682:21500912:215011290.32541.8485e-036.0098e-130.4568imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;ZC3H7B;ZNF184NAB_cells_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000174839.11,DENND6A
CESCEAGMEXENSG00000160741.12chr1153947677:153948329:153948457:153948644:153952017:153952262:153952396:1539524460.31583.0964e-032.5308e-100.4065imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL1;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;YTHDF1;ZC3H7B;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr3:57626416-57627449:-
CESCEERIRENSG00000068438.10chrX48482596:48482794:48482985:484830270.28751.3200e-024.6570e-180.5391imageNCNBP;DDX54;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;HNRNPA1;HNRNPK;IGF2BP1;IGF2BP2;IGF2BP3;LIN28B;NOP56;NOP58;PRPF8;PTBP1;RBM10;RBM47;TAF15;TIA1;TIAL1;U2AF2;UPF1NAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr3:57626416-57627449:-
CESCEERMEXENSG00000165819.7chr1421499024:21499137:21499305:21499371:21500494:21500682:21500912:215011290.28161.9260e-022.6186e-120.4480imageNCNBP;DDX54;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;HNRNPA1;HNRNPK;IGF2BP1;IGF2BP2;IGF2BP3;LIN28B;NOP56;NOP58;PRPF8;PTBP1;RBM10;TAF15;TIA1;TIAL1;U2AF2;UPF1NAB_cells_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
chr3:57626416-57627449:-
CESCEERIRENSG00000008952.12chr3169992593:169993101:169993654:169993831-0.26453.7036e-021.1122e-25-0.6284imageNCNBP;DDX54;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;HNRNPA1;HNRNPK;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS3;LIN28B;NOP56;NOP58;PRPF8;PTBP1;RBM10;RBM47;TAF15;TIA1;TIAL1;U2AF2;UPF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000174839.11,DENND6A
CESCEAGIRENSG00000008952.12chr3169992593:169993101:169993654:169993831-0.30066.6089e-035.2506e-17-0.5213imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;YTHDF1;ZC3H7B;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000174839.11,DENND6A
CESCEAGIRENSG00000136448.7chr1745105764:45105945:45107778:45108134-0.29697.7365e-036.7179e-18-0.5338imageNACIN1;ADAR;AIFM1;ALKBH5;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;YTHDF1;ZC3H7B;ZNF184NAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000174839.11,DENND6A
CESCEAGMEXENSG00000125970.7chr2034072065:34072330:34073562:34073635:34077027:34077245:34078504:34078545-0.29627.7501e-031.2719e-12-0.4510imageNACIN1;ADAR;AIFM1;AUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;LARP4B;LIN28;LIN28A;LIN28B;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;RBM5;SF3B4;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;YTHDF1;ZC3H7B;ZNF184NAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE

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5. Enriched editing regions and immune infiltration for DENND6A


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr3:57626416-57627449:-BLCAEERT_cells_CD4_memory_activated1.1733e-040.2456image
ENSG00000174839.11,DENND6ABLCAEAGT_cells_CD4_memory_activated2.7381e-040.2310image
chr3:57626416-57627449:-BRCAEERB_cells_naive1.5222e-06-0.1626image
ENSG00000174839.11,DENND6ABRCAEAGB_cells_naive2.3220e-05-0.1430image
chr3:57626416-57627449:-CESCEERDendritic_cells_activated2.3752e-030.2034image
ENSG00000174839.11,DENND6ACESCEAGDendritic_cells_activated1.0738e-030.2171image
ENSG00000174839.11,DENND6ACHOLEAGT_cells_gamma_delta4.9344e-020.4238image
chr3:57626416-57627449:-COADEERDendritic_cells_activated1.0642e-030.2988image
ENSG00000174839.11,DENND6ACOADEAGEosinophils4.5694e-050.3603image
chr3:57626416-57627449:-ESCAEERB_cells_naive3.2548e-03-0.2388image
ENSG00000174839.11,DENND6AESCAEAGT_cells_regulatory_(Tregs)7.5570e-04-0.2669image
chr3:57626416-57627449:-GBMEERNeutrophils7.8953e-03-0.2140image
ENSG00000174839.11,DENND6AGBMEAGNeutrophils7.8953e-03-0.2140image
chr3:57626416-57627449:-HNSCEERT_cells_regulatory_(Tregs)1.3231e-02-0.1224image
ENSG00000174839.11,DENND6AHNSCEAGT_cells_regulatory_(Tregs)1.0323e-02-0.1265image
chr3:57626416-57627449:-KIRCEERT_cells_follicular_helper1.6377e-030.1826image
ENSG00000174839.11,DENND6AKIRCEAGT_cells_follicular_helper1.9510e-030.1779image
chr3:57626416-57627449:-KIRPEERNeutrophils3.7245e-02-0.1756image
ENSG00000174839.11,DENND6AKIRPEAGB_cells_naive3.4535e-02-0.1769image
chr3:57626416-57627449:-LGGEERT_cells_CD4_memory_activated5.6118e-030.1533image
ENSG00000174839.11,DENND6ALGGEAGT_cells_CD4_naive4.2363e-030.1580image
ENSG00000174839.11,DENND6ALIHCEAGNK_cells_activated1.5977e-020.1939image
chr3:57626416-57627449:-LUADEERDendritic_cells_activated2.5112e-020.1276image
ENSG00000174839.11,DENND6ALUADEAGEosinophils1.2523e-080.3148image
chr3:57626416-57627449:-MESOEERMast_cells_resting3.5521e-02-0.2633image
ENSG00000174839.11,DENND6AMESOEAGMast_cells_resting3.5521e-02-0.2633image
chr3:57626416-57627449:-OVEERDendritic_cells_activated1.8686e-020.1452image
ENSG00000174839.11,DENND6AOVEAGDendritic_cells_activated4.2488e-020.1252image
chr3:57626416-57627449:-PAADEERT_cells_CD81.0006e-02-0.2515image
ENSG00000174839.11,DENND6APAADEAGNK_cells_activated2.5055e-020.2197image
ENSG00000174839.11,DENND6APCPGEAGB_cells_naive2.0967e-020.2881image
chr3:57626416-57627449:-PRADEERPlasma_cells8.3069e-03-0.1673image
ENSG00000174839.11,DENND6APRADEAGT_cells_gamma_delta1.7143e-030.1958image
chr3:57626416-57627449:-SARCEERNK_cells_resting1.8482e-02-0.1795image
ENSG00000174839.11,DENND6ASARCEAGNK_cells_activated1.0558e-020.1934image
chr3:57626416-57627449:-STADEERNeutrophils8.8585e-050.2305image
ENSG00000174839.11,DENND6ASTADEAGEosinophils3.3565e-040.2011image
ENSG00000174839.11,DENND6ATGCTEAGNK_cells_activated2.7602e-020.2945image
chr3:57626416-57627449:-THCAEERNeutrophils3.1652e-02-0.1189image
ENSG00000174839.11,DENND6ATHCAEAGT_cells_CD4_memory_activated4.6943e-020.1096image
chr3:57626416-57627449:-UCECEEREosinophils3.1330e-030.2985image
ENSG00000174839.11,DENND6AUCECEAGEosinophils2.8742e-020.2177image


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6. Enriched editing regions and immune gene sets for DENND6A


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr3:57626416-57627449:-THCAEER4.1272e-02image2.2670e-020.1260image
ENSG00000174839.11,DENND6ATHCAEAG2.9154e-02image1.5850e-020.1329image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000174839.11,DENND6ABLCAGSVA_HALLMARK_HEME_METABOLISMEAG3.4240e-03-0.1867image
chr3:57626416-57627449:-BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER9.6309e-040.2113image
ENSG00000174839.11,DENND6ABRCAGSVA_HALLMARK_UV_RESPONSE_DNEAG4.0597e-11-0.2215image
chr3:57626416-57627449:-BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.5643e-140.2572image
chr3:57626416-57627449:-CESCGSVA_HALLMARK_UV_RESPONSE_DNEER7.7397e-04-0.2245image
ENSG00000174839.11,DENND6ACESCGSVA_HALLMARK_UV_RESPONSE_DNEAG1.8144e-04-0.2476image
ENSG00000174839.11,DENND6ACHOLGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.7686e-03-0.6065image
chr3:57626416-57627449:-COADGSVA_HALLMARK_SPERMATOGENESISEER7.5000e-03-0.2460image
ENSG00000174839.11,DENND6ACOADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG1.3891e-04-0.3382image
ENSG00000174839.11,DENND6AESCAGSVA_HALLMARK_MTORC1_SIGNALINGEAG6.5569e-040.2699image
chr3:57626416-57627449:-ESCAGSVA_HALLMARK_MTORC1_SIGNALINGEER3.0747e-040.2907image
chr3:57626416-57627449:-GBMGSVA_HALLMARK_MYOGENESISEER6.5987e-030.2187image
ENSG00000174839.11,DENND6AGBMGSVA_HALLMARK_MYOGENESISEAG6.5987e-030.2187image
ENSG00000174839.11,DENND6AHNSCGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.9649e-07-0.2499image
chr3:57626416-57627449:-HNSCGSVA_HALLMARK_MITOTIC_SPINDLEEER8.6365e-07-0.2405image
ENSG00000174839.11,DENND6AKIRCGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.4926e-07-0.2860image
chr3:57626416-57627449:-KIRCGSVA_HALLMARK_MITOTIC_SPINDLEEER9.8268e-06-0.2542image
chr3:57626416-57627449:-KIRPGSVA_HALLMARK_UV_RESPONSE_DNEER3.3547e-04-0.2978image
ENSG00000174839.11,DENND6AKIRPGSVA_HALLMARK_UV_RESPONSE_DNEAG8.7843e-05-0.3220image
ENSG00000174839.11,DENND6ALGGGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.2224e-09-0.3181image
chr3:57626416-57627449:-LGGGSVA_HALLMARK_MITOTIC_SPINDLEEER9.4928e-09-0.3116image
chr3:57626416-57627449:-LIHCGSVA_HALLMARK_MITOTIC_SPINDLEEER9.0226e-04-0.2665image
ENSG00000174839.11,DENND6ALIHCGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.7327e-04-0.2981image
ENSG00000174839.11,DENND6ALUADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG5.9206e-05-0.2250image
chr3:57626416-57627449:-LUADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.7917e-03-0.1773image
chr3:57626416-57627449:-LUSCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER6.8127e-06-0.2262image
ENSG00000174839.11,DENND6ALUSCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG8.6832e-06-0.2234image
ENSG00000174839.11,DENND6AMESOGSVA_HALLMARK_MYC_TARGETS_V2EAG2.0620e-030.3782image
chr3:57626416-57627449:-MESOGSVA_HALLMARK_MYC_TARGETS_V2EER2.0620e-030.3782image
ENSG00000174839.11,DENND6AOVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.2831e-070.3125image
chr3:57626416-57627449:-OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.3415e-070.3188image
ENSG00000174839.11,DENND6APAADGSVA_HALLMARK_SPERMATOGENESISEAG7.9791e-05-0.3770image
chr3:57626416-57627449:-PAADGSVA_HALLMARK_SPERMATOGENESISEER1.6964e-04-0.3606image
ENSG00000174839.11,DENND6APCPGGSVA_HALLMARK_MYC_TARGETS_V1EAG2.9386e-02-0.2725image
ENSG00000174839.11,DENND6APRADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG8.0303e-07-0.3038image
chr3:57626416-57627449:-PRADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER8.1875e-05-0.2475image
ENSG00000174839.11,DENND6AREADGSVA_HALLMARK_GLYCOLYSISEAG1.4158e-020.4295image
chr3:57626416-57627449:-SARCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER3.5370e-040.2693image
ENSG00000174839.11,DENND6ASARCGSVA_HALLMARK_COAGULATIONEAG8.1503e-040.2515image
chr3:57626416-57627449:-SKCMGSVA_HALLMARK_UV_RESPONSE_DNEER1.1496e-04-0.2272image
ENSG00000174839.11,DENND6ASKCMGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.1141e-05-0.2574image
ENSG00000174839.11,DENND6ASTADGSVA_HALLMARK_COAGULATIONEAG7.6043e-030.1504image
chr3:57626416-57627449:-STADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.0269e-040.2284image
ENSG00000174839.11,DENND6ATGCTGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.4172e-030.4163image
chr3:57626416-57627449:-THCAGSVA_HALLMARK_HEME_METABOLISMEER1.5701e-06-0.2619image
ENSG00000174839.11,DENND6ATHCAGSVA_HALLMARK_HEME_METABOLISMEAG3.3939e-07-0.2767image
chr3:57626416-57627449:-UCECGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.7457e-03-0.3024image
ENSG00000174839.11,DENND6AUCECGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.1238e-04-0.3516image
chr3:57626416-57627449:-UCSGSVA_HALLMARK_DNA_REPAIREER5.7144e-050.5798image
ENSG00000174839.11,DENND6AUCSGSVA_HALLMARK_DNA_REPAIREAG1.9747e-050.6017image


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7. Enriched editing regions and drugs for DENND6A


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr3:57626416-57627449:-ACCEHT.1864EER3.0447e-030.5148image
ENSG00000174839.11,DENND6AACCEHT.1864EAG3.0447e-030.5148image
ENSG00000174839.11,DENND6ABLCAGefitinibEAG9.3558e-06-0.2800image
chr3:57626416-57627449:-BLCAGefitinibEER1.0196e-05-0.2806image
ENSG00000174839.11,DENND6ABRCACMKEAG3.9279e-11-0.2219image
chr3:57626416-57627449:-BRCACCT007093EER6.3328e-120.2308image
ENSG00000174839.11,DENND6ACESCDasatinibEAG6.5152e-10-0.3986image
chr3:57626416-57627449:-CESCDasatinibEER3.9802e-09-0.3829image
ENSG00000174839.11,DENND6ACHOLCHIR.99021EAG1.7542e-020.5010image
ENSG00000174839.11,DENND6ACOADCCT007093EAG3.8861e-06-0.4042image
chr3:57626416-57627449:-COADLFM.A13EER2.0705e-03-0.2820image
ENSG00000174839.11,DENND6AESCADocetaxelEAG1.3381e-05-0.3408image
chr3:57626416-57627449:-ESCAErlotinibEER1.6668e-05-0.3436image
chr3:57626416-57627449:-GBMBAY.61.3606EER1.2450e-050.3452image
ENSG00000174839.11,DENND6AGBMBAY.61.3606EAG1.2450e-050.3452image
ENSG00000174839.11,DENND6AHNSCErlotinibEAG7.0906e-10-0.2984image
chr3:57626416-57627449:-HNSCErlotinibEER6.6676e-09-0.2818image
chr3:57626416-57627449:-KIRCBAY.61.3606EER2.7263e-090.3375image
ENSG00000174839.11,DENND6AKIRCBAY.61.3606EAG2.8937e-070.2905image
chr3:57626416-57627449:-KIRPBMS.536924EER3.4015e-04-0.2985image
ENSG00000174839.11,DENND6AKIRPBMS.536924EAG5.6504e-05-0.3313image
ENSG00000174839.11,DENND6ALAMLBMS.754807EAG2.8909e-02-0.4059image
ENSG00000174839.11,DENND6ALGGEmbelinEAG2.6466e-100.3407image
chr3:57626416-57627449:-LGGDoxorubicinEER2.3538e-050.2322image
chr3:57626416-57627449:-LIHCLapatinibEER1.0626e-020.2087image
ENSG00000174839.11,DENND6ALIHCLapatinibEAG1.7427e-020.1933image
ENSG00000174839.11,DENND6ALUADGemcitabineEAG9.9873e-05-0.2181image
chr3:57626416-57627449:-LUADGemcitabineEER6.0992e-04-0.1942image
chr3:57626416-57627449:-LUSCAZD6482EER5.0491e-040.1758image
ENSG00000174839.11,DENND6ALUSCAZD6482EAG1.6604e-040.1898image
chr3:57626416-57627449:-MESOEHT.1864EER5.7615e-030.3414image
ENSG00000174839.11,DENND6AMESOEHT.1864EAG5.7615e-030.3414image
chr3:57626416-57627449:-OVBAY.61.3606EER3.7202e-080.3319image
ENSG00000174839.11,DENND6AOVBAY.61.3606EAG1.3614e-060.2927image
ENSG00000174839.11,DENND6APAADAZD6244EAG1.5435e-03-0.3067image
chr3:57626416-57627449:-PAADAZD6244EER2.8298e-03-0.2900image
ENSG00000174839.11,DENND6APCPGEtoposideEAG9.3352e-040.4039image
ENSG00000174839.11,DENND6APRADAZD.2281EAG7.4429e-07-0.3058image
chr3:57626416-57627449:-PRADAZD.2281EER5.7176e-03-0.1757image
ENSG00000174839.11,DENND6AREADMidostaurinEAG1.2410e-030.5455image
chr3:57626416-57627449:-SARCBexaroteneEER1.7877e-04-0.2820image
ENSG00000174839.11,DENND6ASARCAZD.2281EAG3.5251e-06-0.3433image
chr3:57626416-57627449:-SKCMGNF.2EER4.9122e-04-0.2059image
ENSG00000174839.11,DENND6ASKCMBIBW2992EAG2.7529e-06-0.2741image
chr3:57626416-57627449:-STADLapatinibEER8.1846e-040.1989image
ENSG00000174839.11,DENND6ASTADBAY.61.3606EAG9.2436e-040.1860image
ENSG00000174839.11,DENND6ATGCTGW.441756EAG7.3505e-03-0.3545image
chr3:57626416-57627449:-THCAEmbelinEER3.1377e-140.4034image
ENSG00000174839.11,DENND6ATHCAEmbelinEAG1.3948e-150.4212image
chr3:57626416-57627449:-UCECBIRB.0796EER1.0075e-03-0.3305image
ENSG00000174839.11,DENND6AUCECAZD6482EAG1.3853e-030.3140image
chr3:57626416-57627449:-UCSBMS.509744EER9.6719e-05-0.5651image
ENSG00000174839.11,DENND6AUCSBMS.509744EAG2.8068e-05-0.5928image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType