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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: PDE12 (ImmuneEditome ID:201626)

1. Gene summary of enriched editing regions for PDE12

check button Gene summary
Gene informationGene symbol

PDE12

Gene ID

201626

GeneSynonyms2'-PDE|2-PDE
GeneCytomap

3p14.3

GeneTypeprotein-coding
GeneDescription2',5'-phosphodiesterase 12|2'-phosphodiesterase|mitochondrial deadenylase
GeneModificationdate20230404
UniprotIDQ6L8Q7;F6T1Q0
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr3:57563144-57565833:+ENST00000311180.8ENSG00000174840.8PDE12UTR3AluJr,AluSc,AluJb,AluJo,AluSz,L1PA6,L1MA3chr3:57563144-57565833:+.alignment


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2. Tumor-specific enriched editing regions for PDE12


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr3:57563144-57565833:+BRCAEER5.1543e-03image
ENSG00000174840.8,PDE12BRCAEAG5.7039e-03image
chr3:57563144-57565833:+KIRCEER8.6605e-03image
ENSG00000174840.8,PDE12KIRCEAG1.1128e-02image
chr3:57563144-57565833:+LUSCEER2.5527e-02image
ENSG00000174840.8,PDE12LUSCEAG2.5527e-02image
chr3:57563144-57565833:+STADEER3.3728e-02image
ENSG00000174840.8,PDE12STADEAG3.8752e-02image
chr3:57563144-57565833:+THCAEER4.5507e-02image
ENSG00000174840.8,PDE12THCAEAG4.5507e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr3:57563144-57565833:+KIRCPathEER4.5442e-025.5166e-030.2171image
ENSG00000174840.8,PDE12KIRCPathEAG3.5766e-024.2045e-030.2231image
chr3:57563144-57565833:+THCAPathEER4.0157e-021.3695e-020.1202image
ENSG00000174840.8,PDE12THCAPathEAG4.0157e-021.3695e-020.1202image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for PDE12


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr3:57563144-57565833:+ESCAEERENSG00000131966,ACTR100.35955.7670e-031.3729e-070.4377imageNADAR;CSTF2T;EIF4A3;ELAVL1;FBL;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;MSI1;RBM47;SRSF3;SRSF9;TARDBP;U2AF1;U2AF2;UPF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr3:57563144-57565833:+ESCAEERENSG00000185650,ZFP36L10.31501.9883e-022.1531e-080.4621imageNADAR;CSTF2T;EIF4A3;ELAVL1;FBL;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;MSI1;RBM47;SRSF3;SRSF9;TARDBP;U2AF1;U2AF2;UPF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_HYPOXIA
chr3:57563144-57565833:+ESCAEERENSG00000175183,CSRP20.30052.8600e-025.5087e-070.4181imageNEIF4A3;ELAVL1;FBL;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;MSI1;SRSF3;TARDBP;U2AF2;UPF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:57563144-57565833:+ESCAEERENSG00000153976,HS3ST3A10.29064.0363e-023.2380e-070.4258imageNADAR;CSTF2T;EIF4A3;ELAVL1;FBL;FUS;HNRNPA1;HNRNPC;IGF2BP2;MSI1;SRSF3;SRSF9;TARDBP;U2AF1;U2AF2;UPF1NAT_cells_CD4_naiveGSVA_HALLMARK_HYPOXIA
chr3:57563144-57565833:+ESCAEERENSG00000100504,PYGL0.27874.5190e-021.6166e-060.4020imageNADAR;CSTF2T;EIF4A3;ELAVL1;FBL;FUS;HNRNPA1;HNRNPC;IGF2BP2;MSI1;RBM47;SRSF3;SRSF9;TARDBP;U2AF1;U2AF2;UPF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr3:57563144-57565833:+OVEERENSG00000169241,SLC50A10.41432.8298e-081.3911e-110.4083imageNADAR;CSTF2T;EIF4A3;ELAVL1;FBL;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;RBM47;SRSF3;SRSF9;TARDBP;U2AF1;U2AF2;UPF1SLC50A1Macrophages_M1GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION

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4. Enriched editing regions and immune related splicing for PDE12


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr3:57563144-57565833:+
ESCAEERESENSG00000120868.9chr1298699495:98699569:98703370:98703499:98706484:98706610-0.36281.3035e-023.5878e-06-0.4135imageNADAR;CSTF2T;EIF4A3;ELAVL1;FBL;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;MSI1;RBM47;SRSF3;SRSF9;TARDBP;U2AF1;U2AF2;UPF1APAF1GSVA_HALLMARK_PEROXISOME
chr3:57563144-57565833:+
ESCAEERIRENSG00000159140.13chr2133568970:33569087:33569223:33569283-0.27503.7347e-027.5691e-06-0.4160imageNADAR;CSTF2T;EIF4A3;ELAVL1;FBL;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;METTL3;MSI1;RBM47;SRSF3;SRSF9;TARBP2;TARDBP;U2AF1;U2AF2;UPF1SONT_cells_regulatory_(Tregs)GSVA_HALLMARK_P53_PATHWAY
chr3:57563144-57565833:+
ESCAEERA3ENSG00000177885.9chr1775321658:75321753:75318075:75318796:75318075:75320550-0.29624.5961e-021.0583e-05-0.4268imageNADAR;CSTF2T;EIF4A3;ELAVL1;FBL;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;METTL3;MSI1;RBM47;SRSF3;SRSF9;TARBP2;TARDBP;U2AF1;U2AF2;UPF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr3:57563144-57565833:+
ESCAEERESENSG00000148700.9chr10110130362:110130486:110132304:110132400:110133325:110133348-0.36502.5806e-028.7365e-07-0.4113imageNADAR;CSTF2T;EIF4A3;ELAVL1;FBL;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;MSI1;RBM47;SRSF3;SRSF9;TARDBP;U2AF1;U2AF2;UPF1ADD3T_cells_regulatory_(Tregs)GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
ENSG00000174840.8,PDE12
ESCAEAGESENSG00000120868.9chr1298699495:98699569:98703370:98703499:98706484:98706610-0.36281.5519e-023.5878e-06-0.4135imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;RNF219;SAFB2;SF3A3;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;U2AF1;U2AF2;UPF1;YTHDC1;ZC3H7B;ZNF184APAF1GSVA_HALLMARK_PEROXISOME
ENSG00000174840.8,PDE12
ESCAEAGIRENSG00000159140.13chr2133568970:33569087:33569223:33569283-0.27504.4581e-027.5691e-06-0.4160imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;RBM5;RNF219;RTCB;SAFB2;SF3A3;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TNRC6A;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1;YTHDF2;ZC3H7B;ZNF184SONT_cells_regulatory_(Tregs)GSVA_HALLMARK_P53_PATHWAY
ENSG00000174840.8,PDE12
ESCAEAGESENSG00000148700.9chr10110130362:110130486:110132304:110132400:110133325:110133348-0.36503.0761e-028.7365e-07-0.4113imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;RBM5;SF3A3;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;U2AF1;U2AF2;UPF1;YTHDC1;ZC3H7B;ZNF184ADD3T_cells_regulatory_(Tregs)GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr3:57563144-57565833:+
PCPGEERMEXENSG00000129657.10chr1777216075:77216088:77216218:77216374:77216374:77216387:77216413:772168020.27821.2968e-021.4899e-050.4088imageNADAR;CSTF2T;EIF4A3;ELAVL1;FBL;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;METTL3;MSI1;RBM47;SRSF3;SRSF9;TARBP2;TARDBP;U2AF1;U2AF2;UPF1NAGSVA_HALLMARK_HYPOXIA
ENSG00000174840.8,PDE12
PCPGEAGMEXENSG00000129657.10chr1777216075:77216088:77216218:77216374:77216374:77216387:77216413:772168020.27821.1983e-021.4899e-050.4088imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;RNF219;RTCB;SAFB2;SF3A3;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TNRC6A;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAGSVA_HALLMARK_HYPOXIA

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5. Enriched editing regions and immune infiltration for PDE12


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr3:57563144-57565833:+ACCEERPlasma_cells2.2453e-020.3074image
ENSG00000174840.8,PDE12ACCEAGPlasma_cells2.2453e-020.3074image
chr3:57563144-57565833:+BLCAEERMacrophages_M24.1931e-040.2765image
ENSG00000174840.8,PDE12BLCAEAGMacrophages_M24.1931e-040.2765image
chr3:57563144-57565833:+BRCAEERMacrophages_M15.5858e-040.1312image
ENSG00000174840.8,PDE12BRCAEAGMacrophages_M15.1294e-040.1320image
chr3:57563144-57565833:+CESCEERB_cells_naive9.1583e-030.3138image
ENSG00000174840.8,PDE12CESCEAGB_cells_naive9.1583e-030.3138image
chr3:57563144-57565833:+COADEERDendritic_cells_activated4.4483e-040.3430image
ENSG00000174840.8,PDE12COADEAGDendritic_cells_activated3.9338e-040.3444image
chr3:57563144-57565833:+ESCAEERT_cells_regulatory_(Tregs)1.8946e-03-0.2670image
ENSG00000174840.8,PDE12ESCAEAGT_cells_regulatory_(Tregs)1.8946e-03-0.2670image
chr3:57563144-57565833:+GBMEERB_cells_naive9.7158e-03-0.2226image
ENSG00000174840.8,PDE12GBMEAGB_cells_naive9.7158e-03-0.2226image
chr3:57563144-57565833:+HNSCEERB_cells_naive2.7088e-02-0.3224image
ENSG00000174840.8,PDE12HNSCEAGB_cells_naive2.7088e-02-0.3224image
chr3:57563144-57565833:+KICHEERT_cells_follicular_helper2.4582e-02-0.3794image
ENSG00000174840.8,PDE12KICHEAGT_cells_follicular_helper2.4582e-02-0.3794image
chr3:57563144-57565833:+KIRCEERT_cells_CD4_memory_activated6.3568e-030.2478image
ENSG00000174840.8,PDE12KIRCEAGT_cells_CD4_memory_activated6.3568e-030.2478image
chr3:57563144-57565833:+KIRPEERMacrophages_M21.5386e-020.1907image
ENSG00000174840.8,PDE12KIRPEAGMacrophages_M21.5386e-020.1907image
ENSG00000174840.8,PDE12LAMLEAGMast_cells_resting1.1295e-020.4421image
chr3:57563144-57565833:+LGGEERB_cells_naive2.1007e-020.1095image
ENSG00000174840.8,PDE12LGGEAGB_cells_naive1.9393e-020.1108image
chr3:57563144-57565833:+LIHCEERMacrophages_M21.0607e-030.2953image
ENSG00000174840.8,PDE12LIHCEAGMacrophages_M21.0607e-030.2953image
chr3:57563144-57565833:+LUADEERMast_cells_activated1.2079e-030.2748image
ENSG00000174840.8,PDE12LUADEAGMast_cells_activated1.1009e-030.2769image
chr3:57563144-57565833:+LUSCEERT_cells_regulatory_(Tregs)7.4762e-030.3478image
ENSG00000174840.8,PDE12LUSCEAGT_cells_regulatory_(Tregs)7.4762e-030.3478image
chr3:57563144-57565833:+MESOEEREosinophils6.4756e-040.5959image
ENSG00000174840.8,PDE12MESOEAGEosinophils6.4756e-040.5959image
chr3:57563144-57565833:+OVEERT_cells_CD81.0967e-020.1597image
ENSG00000174840.8,PDE12OVEAGT_cells_CD81.0967e-020.1597image
chr3:57563144-57565833:+PCPGEERT_cells_CD81.0918e-020.2116image
ENSG00000174840.8,PDE12PCPGEAGT_cells_CD81.0918e-020.2116image
chr3:57563144-57565833:+PRADEERMast_cells_resting2.8623e-020.1168image
ENSG00000174840.8,PDE12PRADEAGMast_cells_resting2.8573e-020.1167image
ENSG00000174840.8,PDE12READEAGMacrophages_M13.3714e-020.3548image
chr3:57563144-57565833:+SKCMEERMacrophages_M23.9037e-03-0.1627image
ENSG00000174840.8,PDE12SKCMEAGMacrophages_M23.9037e-03-0.1627image
chr3:57563144-57565833:+STADEERT_cells_gamma_delta2.1573e-030.1696image
ENSG00000174840.8,PDE12STADEAGT_cells_gamma_delta1.8379e-030.1722image
ENSG00000174840.8,PDE12TGCTEAGNK_cells_resting6.2076e-03-0.5319image
chr3:57563144-57565833:+THCAEERB_cells_memory2.4421e-03-0.1473image
ENSG00000174840.8,PDE12THCAEAGB_cells_memory2.4421e-03-0.1473image
chr3:57563144-57565833:+THYMEERT_cells_CD4_naive8.2572e-06-0.4703image
ENSG00000174840.8,PDE12THYMEAGT_cells_CD4_naive8.2572e-06-0.4703image


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6. Enriched editing regions and immune gene sets for PDE12


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr3:57563144-57565833:+ACCGSVA_HALLMARK_MYC_TARGETS_V2EER8.4954e-03-0.3515image
ENSG00000174840.8,PDE12ACCGSVA_HALLMARK_MYC_TARGETS_V2EAG8.4954e-03-0.3515image
chr3:57563144-57565833:+BLCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER6.2024e-060.3498image
ENSG00000174840.8,PDE12BLCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG6.2024e-060.3498image
ENSG00000174840.8,PDE12BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.7493e-080.2077image
chr3:57563144-57565833:+BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.9251e-080.2122image
chr3:57563144-57565833:+CESCGSVA_HALLMARK_KRAS_SIGNALING_UPEER6.6999e-040.4024image
ENSG00000174840.8,PDE12CESCGSVA_HALLMARK_KRAS_SIGNALING_UPEAG6.6999e-040.4024image
ENSG00000174840.8,PDE12COADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG4.9461e-04-0.3388image
chr3:57563144-57565833:+COADGSVA_HALLMARK_BILE_ACID_METABOLISMEER5.6268e-04-0.3373image
ENSG00000174840.8,PDE12ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEAG7.5278e-03-0.2308image
chr3:57563144-57565833:+ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER7.5278e-03-0.2308image
ENSG00000174840.8,PDE12GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.3182e-030.2747image
chr3:57563144-57565833:+GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.3182e-030.2747image
ENSG00000174840.8,PDE12HNSCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG4.7915e-05-0.5569image
chr3:57563144-57565833:+HNSCGSVA_HALLMARK_BILE_ACID_METABOLISMEER4.7915e-05-0.5569image
chr3:57563144-57565833:+KICHGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER6.4365e-03-0.4518image
ENSG00000174840.8,PDE12KICHGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG6.4365e-03-0.4518image
ENSG00000174840.8,PDE12KIRCGSVA_HALLMARK_MYC_TARGETS_V2EAG2.0515e-020.2113image
chr3:57563144-57565833:+KIRCGSVA_HALLMARK_MYC_TARGETS_V2EER2.0515e-020.2113image
chr3:57563144-57565833:+KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEER1.6806e-03-0.2457image
ENSG00000174840.8,PDE12KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.6806e-03-0.2457image
ENSG00000174840.8,PDE12LAMLGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG2.2366e-020.4025image
chr3:57563144-57565833:+LGGGSVA_HALLMARK_MYC_TARGETS_V2EER4.8509e-05-0.1916image
ENSG00000174840.8,PDE12LGGGSVA_HALLMARK_MYC_TARGETS_V2EAG6.8699e-05-0.1876image
ENSG00000174840.8,PDE12LIHCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG4.0638e-040.3177image
chr3:57563144-57565833:+LIHCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER4.0638e-040.3177image
ENSG00000174840.8,PDE12LUADGSVA_HALLMARK_HYPOXIAEAG6.4671e-030.2324image
chr3:57563144-57565833:+LUADGSVA_HALLMARK_HYPOXIAEER9.7918e-030.2208image
chr3:57563144-57565833:+LUSCGSVA_HALLMARK_IL2_STAT5_SIGNALINGEER2.5465e-020.2933image
ENSG00000174840.8,PDE12LUSCGSVA_HALLMARK_IL2_STAT5_SIGNALINGEAG2.5465e-020.2933image
ENSG00000174840.8,PDE12MESOGSVA_HALLMARK_APICAL_SURFACEEAG1.3408e-020.4538image
chr3:57563144-57565833:+MESOGSVA_HALLMARK_APICAL_SURFACEEER1.3408e-020.4538image
chr3:57563144-57565833:+OVGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER8.0904e-070.3043image
ENSG00000174840.8,PDE12OVGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG8.0904e-070.3043image
chr3:57563144-57565833:+PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.1291e-030.2376image
ENSG00000174840.8,PDE12PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.1291e-030.2376image
ENSG00000174840.8,PDE12READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.0485e-030.4488image
chr3:57563144-57565833:+SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.7043e-020.2071image
ENSG00000174840.8,PDE12SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.7043e-020.2071image
ENSG00000174840.8,PDE12SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG9.8425e-030.1457image
chr3:57563144-57565833:+SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER9.8425e-030.1457image
ENSG00000174840.8,PDE12STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.0563e-030.1520image
chr3:57563144-57565833:+STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER9.8978e-030.1429image
ENSG00000174840.8,PDE12TGCTGSVA_HALLMARK_UV_RESPONSE_DNEAG3.0837e-02-0.4325image
chr3:57563144-57565833:+THCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER1.3016e-060.2333image
ENSG00000174840.8,PDE12THCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG1.3016e-060.2333image
chr3:57563144-57565833:+THYMGSVA_HALLMARK_KRAS_SIGNALING_DNEER5.2917e-050.4310image
ENSG00000174840.8,PDE12THYMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG5.2917e-050.4310image
chr3:57563144-57565833:+UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.8775e-020.2220image
ENSG00000174840.8,PDE12UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.8775e-020.2220image
chr3:57563144-57565833:+UCSGSVA_HALLMARK_HYPOXIAEER7.1652e-040.6538image
ENSG00000174840.8,PDE12UCSGSVA_HALLMARK_HYPOXIAEAG7.1652e-040.6538image


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7. Enriched editing regions and drugs for PDE12


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr3:57563144-57565833:+ACCGW843682XEER1.4595e-030.4188image
ENSG00000174840.8,PDE12ACCGW843682XEAG1.4595e-030.4188image
chr3:57563144-57565833:+BLCACisplatinEER4.8540e-05-0.3164image
ENSG00000174840.8,PDE12BLCACisplatinEAG4.8540e-05-0.3164image
ENSG00000174840.8,PDE12BRCACGP.082996EAG2.0959e-03-0.1170image
chr3:57563144-57565833:+BRCACGP.082996EER1.9530e-03-0.1179image
ENSG00000174840.8,PDE12CESCGSK.650394EAG1.3016e-030.3821image
chr3:57563144-57565833:+CESCGSK.650394EER1.3016e-030.3821image
ENSG00000174840.8,PDE12COADAG.014699EAG5.8585e-04-0.3347image
chr3:57563144-57565833:+COADAG.014699EER5.3508e-04-0.3385image
ENSG00000174840.8,PDE12ESCAKU.55933EAG5.8770e-05-0.3423image
chr3:57563144-57565833:+ESCAKU.55933EER5.8770e-05-0.3423image
chr3:57563144-57565833:+GBMGefitinibEER4.3516e-05-0.3455image
ENSG00000174840.8,PDE12GBMGefitinibEAG4.3516e-05-0.3455image
ENSG00000174840.8,PDE12HNSCCEP.701EAG9.7537e-06-0.5963image
chr3:57563144-57565833:+HNSCCEP.701EER9.7537e-06-0.5963image
chr3:57563144-57565833:+KICHAS601245EER1.2982e-020.4158image
ENSG00000174840.8,PDE12KICHAS601245EAG1.2982e-020.4158image
ENSG00000174840.8,PDE12KIRCCCT007093EAG7.2440e-030.2440image
chr3:57563144-57565833:+KIRCCCT007093EER7.2440e-030.2440image
chr3:57563144-57565833:+KIRPFTI.277EER8.3281e-040.2608image
ENSG00000174840.8,PDE12KIRPFTI.277EAG8.3281e-040.2608image
ENSG00000174840.8,PDE12LAMLCCT018159EAG1.7707e-04-0.6155image
chr3:57563144-57565833:+LGGAxitinibEER1.3960e-060.2267image
ENSG00000174840.8,PDE12LGGAxitinibEAG1.7881e-060.2242image
ENSG00000174840.8,PDE12LIHCCamptothecinEAG1.5272e-020.2210image
chr3:57563144-57565833:+LIHCCamptothecinEER1.5272e-020.2210image
chr3:57563144-57565833:+LUADBryostatin.1EER2.5810e-020.1911image
ENSG00000174840.8,PDE12LUADBosutinibEAG2.4643e-02-0.1926image
chr3:57563144-57565833:+MESOAP.24534EER5.7617e-03-0.4999image
ENSG00000174840.8,PDE12MESOAP.24534EAG5.7617e-03-0.4999image
chr3:57563144-57565833:+OVBAY.61.3606EER2.8000e-040.2266image
ENSG00000174840.8,PDE12OVBAY.61.3606EAG2.8000e-040.2266image
ENSG00000174840.8,PDE12PCPGIPA.3EAG5.1692e-03-0.2319image
chr3:57563144-57565833:+PCPGIPA.3EER5.1692e-03-0.2319image
chr3:57563144-57565833:+PRADGNF.2EER6.5534e-04-0.1813image
ENSG00000174840.8,PDE12PRADGNF.2EAG6.5120e-04-0.1811image
ENSG00000174840.8,PDE12READBexaroteneEAG1.6153e-02-0.3982image
chr3:57563144-57565833:+SARCCCT018159EER1.6438e-02-0.2243image
ENSG00000174840.8,PDE12SARCCCT018159EAG1.6438e-02-0.2243image
ENSG00000174840.8,PDE12SKCMKU.55933EAG5.0317e-03-0.1582image
chr3:57563144-57565833:+SKCMKU.55933EER5.0317e-03-0.1582image
ENSG00000174840.8,PDE12STADBMS.754807EAG4.6953e-030.1565image
chr3:57563144-57565833:+STADJNJ.26854165EER2.5757e-03-0.1667image
ENSG00000174840.8,PDE12TGCTFTI.277EAG6.8758e-030.5263image
ENSG00000174840.8,PDE12THCACI.1040EAG3.3511e-07-0.2456image
chr3:57563144-57565833:+THCACI.1040EER3.3511e-07-0.2456image
ENSG00000174840.8,PDE12THYMABT.263EAG1.8030e-060.4992image
chr3:57563144-57565833:+THYMABT.263EER1.8030e-060.4992image
chr3:57563144-57565833:+UCECJNK.Inhibitor.VIIIEER4.3546e-03-0.3028image
ENSG00000174840.8,PDE12UCECJNK.Inhibitor.VIIIEAG4.3546e-03-0.3028image
ENSG00000174840.8,PDE12UCSDoxorubicinEAG6.4241e-030.5511image
chr3:57563144-57565833:+UCSDoxorubicinEER6.4241e-030.5511image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType