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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: TRIM65 (ImmuneEditome ID:201292)

1. Gene summary of enriched editing regions for TRIM65

check button Gene summary
Gene informationGene symbol

TRIM65

Gene ID

201292

GeneSynonyms4732463G12Rik
GeneCytomap

17q25.1

GeneTypeprotein-coding
GeneDescriptionE3 ubiquitin-protein ligase TRIM65|tripartite motif-containing protein 65
GeneModificationdate20230520
UniprotIDQ6PJ69;K7EM44
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr17:75889103-75890824:-ENST00000269383.6ENSG00000141569.9TRIM65exonicAluJr,AluJo,AluSg,L1M5,L1ME3Bchr17:75889103-75890824:-.alignment


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2. Tumor-specific enriched editing regions for TRIM65


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr17:75889103-75890824:-BRCAEER2.8854e-02image
ENSG00000141569.9,TRIM65BRCAEAG2.6460e-02image
ENSG00000141569.9,TRIM65PRADEAG2.8251e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000141569.9,TRIM65ACCPathEAG2.9443e-023.5711e-02-0.3290image
chr17:75889103-75890824:-ACCPathEER2.9443e-023.5711e-02-0.3290image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr17:75889103-75890824:-LUSCEER3.4108e-023.1795e-021.8455e-02image
ENSG00000141569.9,TRIM65LUSCEAG3.4108e-023.1795e-021.8455e-02image
ENSG00000141569.9,TRIM65MESOEAG4.1611e-023.8825e-026.3429e-04image

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3. Enriched editing regions and immune related genes for TRIM65


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr17:75889103-75890824:-PCPGEERENSG00000120694,HSPH10.29356.8708e-033.4382e-080.4088imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_ANDROGEN_RESPONSE

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4. Enriched editing regions and immune related splicing for TRIM65


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for TRIM65


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr17:75889103-75890824:-BLCAEERMacrophages_M19.0617e-030.1543image
ENSG00000141569.9,TRIM65BLCAEAGMacrophages_M19.0617e-030.1543image
chr17:75889103-75890824:-BRCAEEREosinophils2.3139e-020.0715image
ENSG00000141569.9,TRIM65BRCAEAGDendritic_cells_activated1.0331e-020.0807image
chr17:75889103-75890824:-CESCEERMast_cells_resting4.3913e-02-0.1360image
ENSG00000141569.9,TRIM65CESCEAGMast_cells_resting4.3913e-02-0.1360image
ENSG00000141569.9,TRIM65CHOLEAGT_cells_CD4_naive1.0523e-030.5859image
chr17:75889103-75890824:-COADEERDendritic_cells_activated4.8203e-030.2165image
ENSG00000141569.9,TRIM65COADEAGDendritic_cells_activated4.8203e-030.2165image
chr17:75889103-75890824:-ESCAEERT_cells_follicular_helper2.7950e-02-0.1899image
ENSG00000141569.9,TRIM65ESCAEAGT_cells_follicular_helper2.7950e-02-0.1899image
chr17:75889103-75890824:-GBMEERPlasma_cells3.1940e-020.1783image
ENSG00000141569.9,TRIM65GBMEAGPlasma_cells3.1940e-020.1783image
chr17:75889103-75890824:-HNSCEERB_cells_naive2.2759e-02-0.1136image
ENSG00000141569.9,TRIM65HNSCEAGB_cells_naive2.2759e-02-0.1136image
ENSG00000141569.9,TRIM65KICHEAGDendritic_cells_resting1.3593e-030.6157image
chr17:75889103-75890824:-LGGEEREosinophils7.2547e-030.1220image
ENSG00000141569.9,TRIM65LGGEAGEosinophils7.6869e-030.1212image
chr17:75889103-75890824:-LIHCEERT_cells_CD4_naive2.8656e-030.1736image
ENSG00000141569.9,TRIM65LIHCEAGT_cells_CD4_naive2.8656e-030.1736image
chr17:75889103-75890824:-LUADEERT_cells_gamma_delta5.9043e-070.2304image
ENSG00000141569.9,TRIM65LUADEAGT_cells_gamma_delta5.9043e-070.2304image
chr17:75889103-75890824:-LUSCEEREosinophils3.1797e-030.1481image
ENSG00000141569.9,TRIM65LUSCEAGEosinophils3.1797e-030.1481image
chr17:75889103-75890824:-OVEERT_cells_CD83.8013e-050.2502image
ENSG00000141569.9,TRIM65OVEAGT_cells_CD83.7626e-050.2503image
chr17:75889103-75890824:-PAADEERMonocytes3.3029e-020.1719image
ENSG00000141569.9,TRIM65PAADEAGMonocytes3.3029e-020.1719image
ENSG00000141569.9,TRIM65PRADEAGEosinophils1.4267e-040.1965image
ENSG00000141569.9,TRIM65READEAGMast_cells_resting8.8075e-030.3439image
chr17:75889103-75890824:-SARCEERT_cells_follicular_helper1.9604e-020.1552image
ENSG00000141569.9,TRIM65SARCEAGT_cells_follicular_helper1.9604e-020.1552image
chr17:75889103-75890824:-TGCTEERMacrophages_M28.0662e-07-0.4199image
ENSG00000141569.9,TRIM65TGCTEAGMacrophages_M28.0662e-07-0.4199image
chr17:75889103-75890824:-THCAEERDendritic_cells_activated1.1999e-030.1534image
ENSG00000141569.9,TRIM65THCAEAGDendritic_cells_activated1.0258e-030.1555image
chr17:75889103-75890824:-UCECEERT_cells_gamma_delta2.9705e-020.1806image
ENSG00000141569.9,TRIM65UCECEAGT_cells_gamma_delta2.9705e-020.1806image


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6. Enriched editing regions and immune gene sets for TRIM65


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000141569.9,TRIM65ACCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG4.4180e-02-0.3121image
chr17:75889103-75890824:-ACCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER4.4180e-02-0.3121image
ENSG00000141569.9,TRIM65BLCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.9794e-030.1753image
chr17:75889103-75890824:-BLCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.9794e-030.1753image
chr17:75889103-75890824:-BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.5393e-040.1188image
ENSG00000141569.9,TRIM65BRCAGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.1510e-04-0.1210image
ENSG00000141569.9,TRIM65CESCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG4.0405e-020.1383image
chr17:75889103-75890824:-CESCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER4.0405e-020.1383image
ENSG00000141569.9,TRIM65CHOLGSVA_HALLMARK_MYC_TARGETS_V1EAG3.6709e-03-0.5307image
chr17:75889103-75890824:-COADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER9.3829e-04-0.2530image
ENSG00000141569.9,TRIM65COADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG9.3829e-04-0.2530image
ENSG00000141569.9,TRIM65DLBCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG3.4261e-030.5172image
ENSG00000141569.9,TRIM65ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.8443e-020.1893image
chr17:75889103-75890824:-ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.8443e-020.1893image
chr17:75889103-75890824:-GBMGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER3.5106e-02-0.1752image
ENSG00000141569.9,TRIM65GBMGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG3.5106e-02-0.1752image
ENSG00000141569.9,TRIM65HNSCGSVA_HALLMARK_SPERMATOGENESISEAG5.4369e-03-0.1384image
chr17:75889103-75890824:-HNSCGSVA_HALLMARK_SPERMATOGENESISEER5.4369e-03-0.1384image
chr17:75889103-75890824:-KIRCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.7767e-03-0.1674image
ENSG00000141569.9,TRIM65KIRCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.7767e-03-0.1674image
ENSG00000141569.9,TRIM65KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEAG5.2937e-03-0.1975image
chr17:75889103-75890824:-LAMLGSVA_HALLMARK_DNA_REPAIREER4.2107e-02-0.2549image
ENSG00000141569.9,TRIM65LAMLGSVA_HALLMARK_DNA_REPAIREAG4.2107e-02-0.2549image
chr17:75889103-75890824:-LGGGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER4.1535e-040.1600image
ENSG00000141569.9,TRIM65LGGGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG5.2831e-040.1571image
ENSG00000141569.9,TRIM65LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG5.0542e-080.3117image
chr17:75889103-75890824:-LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEER5.0542e-080.3117image
ENSG00000141569.9,TRIM65LUADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG7.6825e-06-0.2069image
chr17:75889103-75890824:-LUADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER7.6825e-06-0.2069image
chr17:75889103-75890824:-LUSCGSVA_HALLMARK_PROTEIN_SECRETIONEER1.0216e-020.1291image
ENSG00000141569.9,TRIM65LUSCGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.0216e-020.1291image
ENSG00000141569.9,TRIM65OVGSVA_HALLMARK_DNA_REPAIREAG4.9284e-070.3031image
chr17:75889103-75890824:-OVGSVA_HALLMARK_DNA_REPAIREER4.4607e-070.3042image
chr17:75889103-75890824:-PCPGGSVA_HALLMARK_UV_RESPONSE_DNEER1.2465e-030.2463image
ENSG00000141569.9,TRIM65PCPGGSVA_HALLMARK_UV_RESPONSE_DNEAG1.2465e-030.2463image
ENSG00000141569.9,TRIM65PRADGSVA_HALLMARK_G2M_CHECKPOINTEAG4.6020e-05-0.2102image
ENSG00000141569.9,TRIM65READGSVA_HALLMARK_BILE_ACID_METABOLISMEAG2.3346e-020.3001image
chr17:75889103-75890824:-SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.1611e-030.1435image
ENSG00000141569.9,TRIM65SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.1611e-030.1435image
ENSG00000141569.9,TRIM65STADGSVA_HALLMARK_COAGULATIONEAG3.9163e-020.1139image
chr17:75889103-75890824:-STADGSVA_HALLMARK_COAGULATIONEER1.6027e-020.1331image
ENSG00000141569.9,TRIM65TGCTGSVA_HALLMARK_MYOGENESISEAG3.6678e-07-0.4315image
chr17:75889103-75890824:-TGCTGSVA_HALLMARK_MYOGENESISEER3.6678e-07-0.4315image
ENSG00000141569.9,TRIM65THCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG4.2318e-03-0.1357image
chr17:75889103-75890824:-THCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.4495e-03-0.1349image
ENSG00000141569.9,TRIM65THYMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.7823e-020.2643image
ENSG00000141569.9,TRIM65UCSGSVA_HALLMARK_MYC_TARGETS_V2EAG4.3955e-02-0.2952image
ENSG00000141569.9,TRIM65UVMGSVA_HALLMARK_MYC_TARGETS_V1EAG1.8561e-03-0.4770image


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7. Enriched editing regions and drugs for TRIM65


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr17:75889103-75890824:-ACCKIN001.135EER3.6242e-02-0.3241image
ENSG00000141569.9,TRIM65ACCKIN001.135EAG3.6242e-02-0.3241image
ENSG00000141569.9,TRIM65BLCAAZD7762EAG1.8542e-02-0.1394image
chr17:75889103-75890824:-BLCAAZD7762EER1.8542e-02-0.1394image
chr17:75889103-75890824:-BRCAAxitinibEER3.1402e-040.1132image
ENSG00000141569.9,TRIM65BRCAAxitinibEAG2.0734e-040.1165image
ENSG00000141569.9,TRIM65CESCMetforminEAG5.0724e-030.1883image
chr17:75889103-75890824:-CESCMetforminEER5.0724e-030.1883image
ENSG00000141569.9,TRIM65CHOLAKT.inhibitor.VIIIEAG1.3037e-04-0.6606image
chr17:75889103-75890824:-COADAZ628EER4.3552e-030.2189image
ENSG00000141569.9,TRIM65COADAZ628EAG4.3552e-030.2189image
ENSG00000141569.9,TRIM65DLBCGW843682XEAG1.0009e-03-0.5703image
ENSG00000141569.9,TRIM65ESCAFH535EAG1.1349e-020.2181image
chr17:75889103-75890824:-ESCAFH535EER1.1349e-020.2181image
ENSG00000141569.9,TRIM65GBMKIN001.135EAG9.0298e-030.2161image
chr17:75889103-75890824:-GBMKIN001.135EER9.0298e-030.2161image
ENSG00000141569.9,TRIM65HNSCBAY.61.3606EAG1.3923e-040.1889image
chr17:75889103-75890824:-HNSCBAY.61.3606EER1.3923e-040.1889image
ENSG00000141569.9,TRIM65KICHCCT018159EAG9.2916e-030.5194image
ENSG00000141569.9,TRIM65KIRCCHIR.99021EAG9.8265e-050.2078image
chr17:75889103-75890824:-KIRCCHIR.99021EER9.8265e-050.2078image
ENSG00000141569.9,TRIM65KIRPAZD6482EAG1.8089e-030.2204image
chr17:75889103-75890824:-LAMLBicalutamideEER1.0007e-02-0.3198image
ENSG00000141569.9,TRIM65LAMLBicalutamideEAG1.0007e-02-0.3198image
ENSG00000141569.9,TRIM65LGGEmbelinEAG2.0946e-060.2139image
chr17:75889103-75890824:-LGGEmbelinEER1.6854e-060.2158image
ENSG00000141569.9,TRIM65LIHCBMS.708163EAG2.5328e-05-0.2434image
chr17:75889103-75890824:-LIHCBMS.708163EER2.5328e-05-0.2434image
ENSG00000141569.9,TRIM65LUADAKT.inhibitor.VIIIEAG3.2048e-07-0.2356image
chr17:75889103-75890824:-LUADAKT.inhibitor.VIIIEER3.2048e-07-0.2356image
ENSG00000141569.9,TRIM65LUSCMidostaurinEAG8.1081e-03-0.1330image
chr17:75889103-75890824:-LUSCMidostaurinEER8.1081e-03-0.1330image
ENSG00000141569.9,TRIM65MESOAS601245EAG1.5298e-02-0.2974image
chr17:75889103-75890824:-OVDMOGEER4.6073e-040.2137image
ENSG00000141569.9,TRIM65OVDMOGEAG4.4991e-040.2141image
ENSG00000141569.9,TRIM65PAADEmbelinEAG1.3217e-02-0.1993image
chr17:75889103-75890824:-PAADEmbelinEER1.3217e-02-0.1993image
ENSG00000141569.9,TRIM65PCPGBIBW2992EAG2.0880e-030.2351image
chr17:75889103-75890824:-PCPGBIBW2992EER2.0880e-030.2351image
ENSG00000141569.9,TRIM65PRADBryostatin.1EAG2.2231e-04-0.1908image
ENSG00000141569.9,TRIM65READIPA.3EAG1.4152e-030.4128image
ENSG00000141569.9,TRIM65SKCMCCT007093EAG5.2972e-040.1810image
chr17:75889103-75890824:-SKCMCCT007093EER5.2972e-040.1810image
ENSG00000141569.9,TRIM65STADGNF.2EAG2.3848e-05-0.2310image
chr17:75889103-75890824:-STADGNF.2EER1.1415e-05-0.2400image
chr17:75889103-75890824:-TGCTFTI.277EER3.5112e-070.4322image
ENSG00000141569.9,TRIM65TGCTFTI.277EAG3.5112e-070.4322image
ENSG00000141569.9,TRIM65THCABX.795EAG9.0282e-040.1572image
chr17:75889103-75890824:-THCABX.795EER1.4471e-030.1509image
ENSG00000141569.9,TRIM65THYMBIRB.0796EAG1.7512e-030.3445image
ENSG00000141569.9,TRIM65UCECA.770041EAG9.6405e-08-0.4254image
chr17:75889103-75890824:-UCECA.770041EER9.6405e-08-0.4254image
ENSG00000141569.9,TRIM65UVMGSK269962AEAG3.0888e-02-0.3418image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType