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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: CC2D1B (ImmuneEditome ID:200014)

1. Gene summary of enriched editing regions for CC2D1B

check button Gene summary
Gene informationGene symbol

CC2D1B

Gene ID

200014

GeneSynonymsLgd1
GeneCytomap

1p32.3

GeneTypeprotein-coding
GeneDescriptioncoiled-coil and C2 domain-containing protein 1B|FRE under dual repression-binding protein 2|five prime repressor element under dual repression-binding protein 2|freud-2|lethal (2) giant discs homolog 1
GeneModificationdate20230329
UniprotIDQ5T0F9
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr1:52347499-52348286:-ENST00000470844.4ENSG00000154222.13CC2D1BncRNA_intronicAluJr,L1MC4,AluSx1chr1:52347499-52348286:-.alignment
chr1:52349967-52351907:-ENST00000470844.4ENSG00000154222.13CC2D1BncRNA_intronicAluSp,AluSx1chr1:52349967-52351907:-.alignment


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2. Tumor-specific enriched editing regions for CC2D1B


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr1:52349967-52351907:-BRCAEER2.8742e-05image
ENSG00000154222.13,CC2D1BBRCAEAG3.3380e-05image
chr1:52349967-52351907:-LUSCEER5.8103e-06image
ENSG00000154222.13,CC2D1BLUSCEAG5.8404e-06image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr1:52349967-52351907:-LUADPathEER3.0191e-024.7943e-020.1030image
ENSG00000154222.13,CC2D1BLUADPathEAG3.0200e-024.7955e-020.1030image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for CC2D1B


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr1:52349967-52351907:-THYMEERENSG00000103275,UBE2I-0.38101.1970e-034.3480e-06-0.4152imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr1:52349967-52351907:-THYMEERENSG00000205464,ATP6AP1L-0.37301.4288e-039.8709e-06-0.4009imageNNNAMacrophages_M1GSVA_HALLMARK_E2F_TARGETS
chr1:52349967-52351907:-THYMEERENSG00000197746,PSAP0.35952.3043e-035.3251e-090.5131imageNNNAMacrophages_M1GSVA_HALLMARK_APICAL_JUNCTION
chr1:52349967-52351907:-THYMEERENSG00000101160,CTSZ0.33525.5551e-035.3497e-060.4117imageNNCTSZMacrophages_M1GSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr1:52349967-52351907:-THYMEERENSG00000117543,DPH5-0.32855.7911e-039.9665e-06-0.4007imageNNNAMacrophages_M1GSVA_HALLMARK_DNA_REPAIR
chr1:52349967-52351907:-THYMEERENSG00000114554,PLXNA10.32886.1140e-031.1231e-060.4376imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr1:52349967-52351907:-THYMEERENSG00000124596,OARD1-0.31929.6128e-039.9381e-06-0.4008imageNNNAMacrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr1:52349967-52351907:-THYMEERENSG00000100450,GZMH0.31241.0285e-022.9440e-060.4219imageNNGZMHT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:52349967-52351907:-THYMEERENSG00000170909,OSCAR0.31431.0833e-029.9784e-080.4740imageNNOSCARMacrophages_M1GSVA_HALLMARK_SPERMATOGENESIS
chr1:52349967-52351907:-THYMEERENSG00000136059,VILL-0.30811.2496e-026.1715e-06-0.4092imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_ESTROGEN_RESPONSE_LATE

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4. Enriched editing regions and immune related splicing for CC2D1B


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000154222.13,CC2D1B
GBMEAGESENSG00000114698.10chr3146222064:146222092:146223732:146223777:146250959:1462510790.30983.6992e-021.6404e-050.4164imageNADAR;AUH;BCCIP;BUD13;CNBP;CSTF2T;DGCR8;DKC1;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LIN28B;MOV10;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM47;SF3A3;SF3B4;SLTM;SMNDC1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;YTHDC1PLSCR4GSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:52349967-52351907:-
GBMEERESENSG00000114698.10chr3146222064:146222092:146223732:146223777:146250959:1462510790.30983.1941e-021.6404e-050.4164imageNNPLSCR4GSVA_HALLMARK_KRAS_SIGNALING_DN
chr1:52349967-52351907:-
THYMEERESENSG00000187609.11chr9137306916:137307263:137307607:137307646:137309606:137309700-0.36153.7199e-032.0721e-05-0.4218imageNNNAGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr1:52349967-52351907:-
THYMEERIRENSG00000133247.9chr1955342741:55343843:55343977:553439970.33222.4469e-021.9159e-050.4134imageNNNANK_cells_activatedGSVA_HALLMARK_DNA_REPAIR
ENSG00000154222.13,CC2D1B
THYMEAGIRENSG00000133247.9chr1955342741:55343843:55343977:553439970.33222.6304e-021.9159e-050.4134imageNADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDF1;YWHAG;ZNF184NANK_cells_activatedGSVA_HALLMARK_DNA_REPAIR
ENSG00000154222.13,CC2D1B
THYMEAGESENSG00000187609.11chr9137306916:137307263:137307607:137307646:137309606:137309700-0.36153.7793e-032.0721e-05-0.4218imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDF1;YWHAG;ZNF184NAGSVA_HALLMARK_XENOBIOTIC_METABOLISM
ENSG00000154222.13,CC2D1B
THYMEAGESENSG00000133112.12chr1345340168:45340184:45340711:45340820:45341041:453410860.34712.9754e-026.2764e-060.4089imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184TPT1T_cells_gamma_deltaGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr1:52349967-52351907:-
THYMEERESENSG00000133112.12chr1345340168:45340184:45340711:45340820:45341041:453410860.34712.7528e-026.2764e-060.4089imageNNTPT1T_cells_gamma_deltaGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY

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5. Enriched editing regions and immune infiltration for CC2D1B


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr1:52349967-52351907:-BLCAEERDendritic_cells_resting2.2918e-02-0.1359image
ENSG00000154222.13,CC2D1BBLCAEAGDendritic_cells_resting2.3195e-02-0.1357image
chr1:52349967-52351907:-CESCEERDendritic_cells_activated3.7384e-02-0.1373image
ENSG00000154222.13,CC2D1BCESCEAGDendritic_cells_activated3.7168e-02-0.1375image
chr1:52349967-52351907:-CHOLEERMacrophages_M12.0580e-020.4432image
ENSG00000154222.13,CC2D1BCHOLEAGMacrophages_M12.0580e-020.4432image
chr1:52349967-52351907:-ESCAEERMacrophages_M21.2344e-020.2232image
ENSG00000154222.13,CC2D1BESCAEAGMacrophages_M21.4840e-020.2175image
chr1:52349967-52351907:-GBMEERT_cells_gamma_delta1.7908e-020.2186image
ENSG00000154222.13,CC2D1BGBMEAGT_cells_gamma_delta1.7908e-020.2186image
chr1:52349967-52351907:-HNSCEERT_cells_CD4_memory_activated2.5618e-020.1544image
ENSG00000154222.13,CC2D1BHNSCEAGT_cells_CD4_memory_activated2.5618e-020.1544image
chr1:52349967-52351907:-KICHEEREosinophils3.8957e-020.2990image
ENSG00000154222.13,CC2D1BKICHEAGEosinophils3.8957e-020.2990image
chr1:52349967-52351907:-KIRCEERMast_cells_activated1.2207e-040.2175image
ENSG00000154222.13,CC2D1BKIRCEAGMast_cells_activated1.2207e-040.2175image
chr1:52349967-52351907:-KIRPEERT_cells_CD4_memory_resting3.8831e-02-0.1310image
ENSG00000154222.13,CC2D1BKIRPEAGT_cells_CD4_memory_resting3.8628e-02-0.1312image
chr1:52349967-52351907:-LUADEERT_cells_CD4_memory_activated3.0229e-040.1873image
ENSG00000154222.13,CC2D1BLUADEAGT_cells_CD4_memory_activated3.0227e-040.1873image
chr1:52349967-52351907:-MESOEERB_cells_naive3.8609e-030.3737image
ENSG00000154222.13,CC2D1BMESOEAGB_cells_naive3.8609e-030.3737image
chr1:52349967-52351907:-PCPGEERNK_cells_resting3.2276e-030.2635image
ENSG00000154222.13,CC2D1BPCPGEAGNK_cells_resting3.2276e-030.2635image
chr1:52349967-52351907:-PRADEERT_cells_CD4_memory_resting1.1718e-020.1290image
ENSG00000154222.13,CC2D1BPRADEAGT_cells_CD4_memory_resting1.1783e-020.1289image
chr1:52349967-52351907:-READEERMast_cells_resting1.3295e-02-0.4331image
ENSG00000154222.13,CC2D1BREADEAGMast_cells_resting1.3295e-02-0.4331image
chr1:52349967-52351907:-SARCEERMast_cells_resting7.7832e-030.2041image
ENSG00000154222.13,CC2D1BSARCEAGMast_cells_resting8.9858e-030.2004image
chr1:52349967-52351907:-SKCMEERT_cells_follicular_helper1.7254e-02-0.1218image
ENSG00000154222.13,CC2D1BSKCMEAGT_cells_follicular_helper1.6822e-02-0.1222image
chr1:52349967-52351907:-STADEERB_cells_naive1.0619e-02-0.1623image
ENSG00000154222.13,CC2D1BSTADEAGB_cells_naive1.2339e-02-0.1590image
chr1:52349967-52351907:-TGCTEERB_cells_naive6.1331e-03-0.2985image
ENSG00000154222.13,CC2D1BTGCTEAGB_cells_naive6.1331e-03-0.2985image
chr1:52349967-52351907:-THCAEERB_cells_naive1.0669e-030.1465image
ENSG00000154222.13,CC2D1BTHCAEAGB_cells_naive9.5252e-040.1479image
chr1:52349967-52351907:-THYMEERMacrophages_M16.2242e-060.4091image
ENSG00000154222.13,CC2D1BTHYMEAGMacrophages_M16.2242e-060.4091image


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6. Enriched editing regions and immune gene sets for CC2D1B


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr1:52349967-52351907:-KIRPEER2.8437e-02image2.3710e-030.1918image
ENSG00000154222.13,CC2D1BKIRPEAG2.8479e-02image2.3728e-030.1918image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000154222.13,CC2D1BBLCAEAG2.7842e-040.21564.8704e-040.20712.8471e-040.21533.5764e-060.2729image
chr1:52349967-52351907:-BLCAEER2.6895e-040.21614.8068e-040.20732.7553e-040.21583.3721e-060.2736image
ENSG00000154222.13,CC2D1BLUADEAG1.0993e-040.20023.9324e-050.21262.1327e-040.19191.9584e-050.2206image
chr1:52349967-52351907:-LUADEER1.0991e-040.20023.9318e-050.21262.1322e-040.19191.9578e-050.2206image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000154222.13,CC2D1BBLCAGSVA_HALLMARK_HEME_METABOLISMEAG1.0885e-080.3333image
chr1:52349967-52351907:-BLCAGSVA_HALLMARK_HEME_METABOLISMEER1.0253e-080.3338image
ENSG00000154222.13,CC2D1BBRCAGSVA_HALLMARK_GLYCOLYSISEAG2.2199e-060.1830image
chr1:52349967-52351907:-BRCAGSVA_HALLMARK_GLYCOLYSISEER2.0583e-060.1837image
ENSG00000154222.13,CC2D1BCESCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG3.9904e-040.2316image
chr1:52349967-52351907:-CESCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER3.9565e-040.2317image
chr1:52349967-52351907:-CHOLGSVA_HALLMARK_UV_RESPONSE_DNEER1.0301e-020.4852image
ENSG00000154222.13,CC2D1BCHOLGSVA_HALLMARK_UV_RESPONSE_DNEAG1.0301e-020.4852image
chr1:52349967-52351907:-COADGSVA_HALLMARK_HYPOXIAEER1.3521e-030.3209image
ENSG00000154222.13,CC2D1BCOADGSVA_HALLMARK_HYPOXIAEAG1.3521e-030.3209image
chr1:52349967-52351907:-ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER2.4845e-020.2007image
ENSG00000154222.13,CC2D1BESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG2.2163e-020.2045image
ENSG00000154222.13,CC2D1BGBMGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG2.0801e-030.2818image
chr1:52349967-52351907:-GBMGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER2.0801e-030.2818image
chr1:52349967-52351907:-HNSCGSVA_HALLMARK_ANGIOGENESISEER3.9194e-02-0.1428image
ENSG00000154222.13,CC2D1BHNSCGSVA_HALLMARK_ANGIOGENESISEAG3.9194e-02-0.1428image
ENSG00000154222.13,CC2D1BKICHGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.0304e-030.4591image
chr1:52349967-52351907:-KICHGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.0304e-030.4591image
ENSG00000154222.13,CC2D1BKIRCGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG9.1837e-050.2214image
chr1:52349967-52351907:-KIRCGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER9.1837e-050.2214image
ENSG00000154222.13,CC2D1BKIRPGSVA_HALLMARK_COAGULATIONEAG1.3164e-040.2400image
chr1:52349967-52351907:-KIRPGSVA_HALLMARK_COAGULATIONEER1.3164e-040.2400image
chr1:52349967-52351907:-LGGGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.9724e-03-0.1704image
ENSG00000154222.13,CC2D1BLGGGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG3.3231e-03-0.1682image
chr1:52349967-52351907:-LIHCGSVA_HALLMARK_DNA_REPAIREER4.1608e-06-0.2988image
ENSG00000154222.13,CC2D1BLIHCGSVA_HALLMARK_DNA_REPAIREAG4.1548e-06-0.2989image
ENSG00000154222.13,CC2D1BLUADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG2.9081e-070.2635image
chr1:52349967-52351907:-LUADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER2.9078e-070.2635image
chr1:52349967-52351907:-LUSCGSVA_HALLMARK_PROTEIN_SECRETIONEER2.7370e-030.1922image
ENSG00000154222.13,CC2D1BLUSCGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.8017e-030.1917image
chr1:52349967-52351907:-OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.0046e-020.1704image
ENSG00000154222.13,CC2D1BOVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.7039e-020.1734image
ENSG00000154222.13,CC2D1BPAADGSVA_HALLMARK_UV_RESPONSE_DNEAG3.2327e-020.1908image
chr1:52349967-52351907:-PAADGSVA_HALLMARK_UV_RESPONSE_DNEER3.2327e-020.1908image
chr1:52349967-52351907:-PCPGGSVA_HALLMARK_MITOTIC_SPINDLEEER2.7915e-020.1983image
ENSG00000154222.13,CC2D1BPCPGGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.7915e-020.1983image
chr1:52349967-52351907:-PRADGSVA_HALLMARK_TGF_BETA_SIGNALINGEER2.9141e-020.1118image
ENSG00000154222.13,CC2D1BPRADGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG2.9135e-020.1118image
chr1:52349967-52351907:-READGSVA_HALLMARK_APOPTOSISEER1.5337e-020.4249image
ENSG00000154222.13,CC2D1BREADGSVA_HALLMARK_APOPTOSISEAG1.5337e-020.4249image
chr1:52349967-52351907:-SARCGSVA_HALLMARK_APICAL_SURFACEEER1.2249e-02-0.1923image
ENSG00000154222.13,CC2D1BSARCGSVA_HALLMARK_APICAL_SURFACEEAG1.3394e-02-0.1899image
chr1:52349967-52351907:-SKCMGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.7324e-020.1217image
ENSG00000154222.13,CC2D1BSKCMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.6735e-020.1224image
ENSG00000154222.13,CC2D1BSTADGSVA_HALLMARK_APOPTOSISEAG3.2605e-030.1865image
chr1:52349967-52351907:-STADGSVA_HALLMARK_APOPTOSISEER2.5980e-030.1908image
ENSG00000154222.13,CC2D1BTGCTGSVA_HALLMARK_COAGULATIONEAG1.8406e-030.3370image
chr1:52349967-52351907:-TGCTGSVA_HALLMARK_COAGULATIONEER1.8406e-030.3370image
chr1:52349967-52351907:-THCAGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.5735e-080.2504image
ENSG00000154222.13,CC2D1BTHCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.5820e-080.2504image
ENSG00000154222.13,CC2D1BTHYMGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG8.0932e-030.2469image
chr1:52349967-52351907:-THYMGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER8.0932e-030.2469image
ENSG00000154222.13,CC2D1BUCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.3460e-030.2952image
chr1:52349967-52351907:-UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.2303e-030.2966image
ENSG00000154222.13,CC2D1BUVMGSVA_HALLMARK_UV_RESPONSE_DNEAG4.2804e-02-0.2820image
chr1:52349967-52351907:-UVMGSVA_HALLMARK_UV_RESPONSE_DNEER4.2804e-02-0.2820image


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7. Enriched editing regions and drugs for CC2D1B


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000154222.13,CC2D1BBLCAAICAREAG6.9624e-07-0.2914image
chr1:52349967-52351907:-BLCAAZD6482EER6.9424e-07-0.2914image
chr1:52349967-52351907:-BRCAEHT.1864EER2.3297e-030.1184image
ENSG00000154222.13,CC2D1BBRCAEHT.1864EAG2.3643e-030.1182image
chr1:52349967-52351907:-CESCAP.24534EER6.1074e-03-0.1803image
ENSG00000154222.13,CC2D1BCESCAP.24534EAG6.1898e-03-0.1800image
ENSG00000154222.13,CC2D1BCHOLMetforminEAG7.1382e-030.5056image
chr1:52349967-52351907:-CHOLMetforminEER7.1382e-030.5056image
chr1:52349967-52351907:-ESCAAZD7762EER5.6859e-04-0.3040image
ENSG00000154222.13,CC2D1BESCAAZD7762EAG6.6624e-04-0.3003image
ENSG00000154222.13,CC2D1BGBMAxitinibEAG6.2973e-03-0.2512image
chr1:52349967-52351907:-GBMAxitinibEER6.2973e-03-0.2512image
chr1:52349967-52351907:-HNSCElesclomolEER2.5027e-030.2081image
ENSG00000154222.13,CC2D1BHNSCElesclomolEAG2.5027e-030.2081image
chr1:52349967-52351907:-KICHEHT.1864EER4.8659e-030.3999image
ENSG00000154222.13,CC2D1BKICHEHT.1864EAG4.8659e-030.3999image
chr1:52349967-52351907:-KIRCDMOGEER9.6694e-03-0.1475image
ENSG00000154222.13,CC2D1BKIRCDMOGEAG9.6694e-03-0.1475image
chr1:52349967-52351907:-KIRPBX.795EER6.7378e-07-0.3087image
ENSG00000154222.13,CC2D1BKIRPBX.795EAG6.7148e-07-0.3087image
chr1:52349967-52351907:-LGGEtoposideEER6.8943e-05-0.2270image
ENSG00000154222.13,CC2D1BLGGEtoposideEAG6.7316e-05-0.2269image
chr1:52349967-52351907:-LIHCAZD.0530EER9.0251e-05-0.2746image
ENSG00000154222.13,CC2D1BLIHCAZD.0530EAG9.0146e-05-0.2746image
ENSG00000154222.13,CC2D1BLUADAKT.inhibitor.VIIIEAG6.9662e-05-0.2058image
chr1:52349967-52351907:-LUADAKT.inhibitor.VIIIEER6.9649e-05-0.2058image
ENSG00000154222.13,CC2D1BLUSCJW.7.52.1EAG4.7527e-03-0.1813image
chr1:52349967-52351907:-LUSCJW.7.52.1EER4.8031e-03-0.1811image
ENSG00000154222.13,CC2D1BMESODMOGEAG8.8588e-03-0.3408image
chr1:52349967-52351907:-MESODMOGEER8.8588e-03-0.3408image
chr1:52349967-52351907:-OVBI.D1870EER4.9238e-030.2054image
ENSG00000154222.13,CC2D1BOVBI.D1870EAG5.7895e-030.2000image
chr1:52349967-52351907:-PCPGDasatinibEER3.4738e-030.2659image
ENSG00000154222.13,CC2D1BPCPGDasatinibEAG3.4738e-030.2659image
chr1:52349967-52351907:-PRADCHIR.99021EER4.6071e-03-0.1449image
ENSG00000154222.13,CC2D1BPRADCHIR.99021EAG4.5815e-03-0.1450image
chr1:52349967-52351907:-SARCLFM.A13EER3.5808e-020.1616image
ENSG00000154222.13,CC2D1BSARCLFM.A13EAG3.9096e-020.1589image
chr1:52349967-52351907:-SKCMAxitinibEER3.5996e-03-0.1486image
ENSG00000154222.13,CC2D1BSKCMAxitinibEAG3.5439e-03-0.1489image
ENSG00000154222.13,CC2D1BSTADBMS.509744EAG3.3503e-02-0.1353image
chr1:52349967-52351907:-STADBMS.509744EER2.1120e-02-0.1467image
ENSG00000154222.13,CC2D1BTGCTBortezomibEAG1.8978e-04-0.3986image
chr1:52349967-52351907:-TGCTBortezomibEER1.8978e-04-0.3986image
chr1:52349967-52351907:-THCAMetforminEER2.0973e-070.2305image
ENSG00000154222.13,CC2D1BTHCAMetforminEAG2.1466e-070.2303image
chr1:52349967-52351907:-THYMDoxorubicinEER1.1782e-040.3529image
ENSG00000154222.13,CC2D1BTHYMDoxorubicinEAG1.1782e-040.3529image
chr1:52349967-52351907:-UCECAZD6244EER4.7793e-03-0.2760image
ENSG00000154222.13,CC2D1BUCECAZD6244EAG4.7762e-03-0.2760image
ENSG00000154222.13,CC2D1BUVMGNF.2EAG3.6841e-02-0.2903image
chr1:52349967-52351907:-UVMGNF.2EER3.6841e-02-0.2903image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType