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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: EIF2B1 (ImmuneEditome ID:1967)

1. Gene summary of enriched editing regions for EIF2B1

check button Gene summary
Gene informationGene symbol

EIF2B1

Gene ID

1967

GeneSynonymsEIF2B|EIF2BA|EIF2Balpha|VWM1
GeneCytomap

12q24.31

GeneTypeprotein-coding
GeneDescriptiontranslation initiation factor eIF-2B subunit alpha|eIF-2B GDP-GTP exchange factor subunit alpha|eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
GeneModificationdate20230506
UniprotIDQ14232;F5H0D0
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr12:123622831-123626143:-ENST00000424014.5ENSG00000111361.11EIF2B1exonicAluSx1,L1M3,(TA)n,Charlie9,AluSq2,AluSx,AluJr,AluYh3,AluJbchr12:123622831-123626143:-.alignment
chr12:123622831-123626143:-ENST00000534960.4ENSG00000111361.11EIF2B1exonicAluSx1,L1M3,(TA)n,Charlie9,AluSq2,AluSx,AluJr,AluYh3,AluJbchr12:123622831-123626143:-.alignment
chr12:123628261-123628576:-ENST00000424014.5ENSG00000111361.11EIF2B1intronicAluJr,AluJbchr12:123628261-123628576:-.alignment
chr12:123628261-123628576:-ENST00000534960.4ENSG00000111361.11EIF2B1intronicAluJr,AluJbchr12:123628261-123628576:-.alignment
chr12:123628261-123628576:-ENST00000537073.1ENSG00000111361.11EIF2B1intronicAluJr,AluJbchr12:123628261-123628576:-.alignment
chr12:123628261-123628576:-ENST00000539951.4ENSG00000111361.11EIF2B1intronicAluJr,AluJbchr12:123628261-123628576:-.alignment


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2. Tumor-specific enriched editing regions for EIF2B1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for EIF2B1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for EIF2B1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for EIF2B1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr12:123622831-123626143:-BRCAEERT_cells_CD4_memory_resting2.2277e-02-0.1210image
ENSG00000111361.11,EIF2B1BRCAEAGT_cells_CD4_memory_resting2.0118e-02-0.1228image
chr12:123622831-123626143:-CESCEERT_cells_CD4_naive1.1689e-030.3126image
ENSG00000111361.11,EIF2B1CESCEAGT_cells_CD4_naive1.1689e-030.3126image
chr12:123622831-123626143:-ESCAEERMast_cells_activated2.6875e-020.2101image
ENSG00000111361.11,EIF2B1ESCAEAGMast_cells_activated9.0322e-030.2468image
chr12:123622831-123626143:-HNSCEERNeutrophils8.8052e-030.4941image
ENSG00000111361.11,EIF2B1HNSCEAGNeutrophils2.0746e-020.4349image
chr12:123622831-123626143:-KIRPEERMast_cells_activated3.8754e-030.3101image
ENSG00000111361.11,EIF2B1KIRPEAGMast_cells_activated3.8754e-030.3101image
chr12:123622831-123626143:-LAMLEERNK_cells_activated3.8219e-020.2252image
ENSG00000111361.11,EIF2B1LAMLEAGNK_cells_activated3.8219e-020.2252image
chr12:123622831-123626143:-LGGEERMast_cells_activated1.4079e-02-0.1493image
ENSG00000111361.11,EIF2B1LGGEAGMast_cells_activated1.4079e-02-0.1493image
chr12:123622831-123626143:-LUADEERDendritic_cells_resting4.8837e-02-0.1518image
ENSG00000111361.11,EIF2B1LUADEAGDendritic_cells_resting4.8837e-02-0.1518image
chr12:123622831-123626143:-LUSCEERT_cells_CD4_memory_resting7.1483e-030.1966image
ENSG00000111361.11,EIF2B1LUSCEAGT_cells_CD4_memory_resting7.1483e-030.1966image
chr12:123622831-123626143:-MESOEERMacrophages_M11.2054e-020.5253image
ENSG00000111361.11,EIF2B1MESOEAGMacrophages_M11.2054e-020.5253image
chr12:123622831-123626143:-PAADEERB_cells_memory1.8082e-020.3472image
ENSG00000111361.11,EIF2B1PAADEAGB_cells_memory1.8082e-020.3472image
chr12:123622831-123626143:-PCPGEERT_cells_CD4_memory_resting5.1235e-03-0.4507image
ENSG00000111361.11,EIF2B1PCPGEAGT_cells_CD4_memory_resting5.1235e-03-0.4507image
chr12:123622831-123626143:-READEERDendritic_cells_activated1.6950e-040.7055image
ENSG00000111361.11,EIF2B1READEAGDendritic_cells_activated1.6950e-040.7055image
chr12:123622831-123626143:-SARCEERT_cells_follicular_helper4.3714e-030.4311image
ENSG00000111361.11,EIF2B1SARCEAGT_cells_follicular_helper4.3714e-030.4311image
chr12:123622831-123626143:-SKCMEEREosinophils1.6525e-020.2454image
ENSG00000111361.11,EIF2B1SKCMEAGEosinophils1.6784e-020.2448image
chr12:123622831-123626143:-STADEERMast_cells_activated9.3208e-030.2089image
ENSG00000111361.11,EIF2B1STADEAGMast_cells_activated1.7080e-020.1889image
chr12:123622831-123626143:-TGCTEERT_cells_follicular_helper1.5181e-02-0.3071image
ENSG00000111361.11,EIF2B1TGCTEAGT_cells_follicular_helper1.5181e-02-0.3071image
chr12:123622831-123626143:-UCECEERB_cells_memory1.2485e-020.4828image
ENSG00000111361.11,EIF2B1UCECEAGB_cells_memory1.0476e-020.4843image


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6. Enriched editing regions and immune gene sets for EIF2B1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000111361.11,EIF2B1BLCAGSVA_HALLMARK_MYC_TARGETS_V2EAG1.8144e-030.3261image
chr12:123622831-123626143:-BLCAGSVA_HALLMARK_MYC_TARGETS_V2EER3.4166e-030.3088image
ENSG00000111361.11,EIF2B1BRCAGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG3.8948e-020.1092image
chr12:123622831-123626143:-BRCAGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER4.2604e-020.1074image
chr12:123622831-123626143:-CESCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER4.0057e-02-0.2007image
ENSG00000111361.11,EIF2B1CESCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG4.0057e-02-0.2007image
ENSG00000111361.11,EIF2B1COADGSVA_HALLMARK_HEME_METABOLISMEAG3.2751e-03-0.3621image
chr12:123622831-123626143:-COADGSVA_HALLMARK_HEME_METABOLISMEER2.1407e-03-0.3798image
ENSG00000111361.11,EIF2B1ESCAGSVA_HALLMARK_P53_PATHWAYEAG1.9689e-040.3463image
chr12:123622831-123626143:-ESCAGSVA_HALLMARK_P53_PATHWAYEER5.7477e-040.3217image
chr12:123622831-123626143:-GBMGSVA_HALLMARK_PANCREAS_BETA_CELLSEER7.0841e-040.4064image
ENSG00000111361.11,EIF2B1GBMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG7.0841e-040.4064image
ENSG00000111361.11,EIF2B1HNSCGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG2.0549e-02-0.4355image
chr12:123622831-123626143:-KIRCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER5.6942e-030.2278image
ENSG00000111361.11,EIF2B1KIRCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG5.6942e-030.2278image
ENSG00000111361.11,EIF2B1KIRPGSVA_HALLMARK_DNA_REPAIREAG3.0508e-02-0.2348image
chr12:123622831-123626143:-KIRPGSVA_HALLMARK_DNA_REPAIREER3.0508e-02-0.2348image
ENSG00000111361.11,EIF2B1LGGGSVA_HALLMARK_APICAL_JUNCTIONEAG1.1409e-020.1538image
chr12:123622831-123626143:-LGGGSVA_HALLMARK_APICAL_JUNCTIONEER1.1409e-020.1538image
ENSG00000111361.11,EIF2B1LUADGSVA_HALLMARK_COMPLEMENTEAG2.7903e-020.1692image
chr12:123622831-123626143:-LUADGSVA_HALLMARK_COMPLEMENTEER2.7903e-020.1692image
chr12:123622831-123626143:-MESOGSVA_HALLMARK_MTORC1_SIGNALINGEER9.1297e-030.5423image
ENSG00000111361.11,EIF2B1MESOGSVA_HALLMARK_MTORC1_SIGNALINGEAG9.1297e-030.5423image
chr12:123622831-123626143:-OVGSVA_HALLMARK_MYC_TARGETS_V1EER2.5941e-020.1896image
ENSG00000111361.11,EIF2B1OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG4.9040e-030.2357image
chr12:123622831-123626143:-PAADGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER9.5737e-030.3781image
ENSG00000111361.11,EIF2B1PAADGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG9.5737e-030.3781image
ENSG00000111361.11,EIF2B1READGSVA_HALLMARK_MYOGENESISEAG2.6650e-02-0.4615image
chr12:123622831-123626143:-READGSVA_HALLMARK_MYOGENESISEER2.6650e-02-0.4615image
ENSG00000111361.11,EIF2B1SARCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG2.9113e-020.3369image
chr12:123622831-123626143:-SARCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER2.9113e-020.3369image
ENSG00000111361.11,EIF2B1SKCMGSVA_HALLMARK_UV_RESPONSE_UPEAG8.0413e-030.2704image
chr12:123622831-123626143:-SKCMGSVA_HALLMARK_UV_RESPONSE_UPEER5.5856e-030.2822image
chr12:123622831-123626143:-STADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER8.9406e-040.2650image
ENSG00000111361.11,EIF2B1STADGSVA_HALLMARK_GLYCOLYSISEAG1.5925e-030.2484image
chr12:123622831-123626143:-THYMGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.6214e-02-0.4036image
ENSG00000111361.11,EIF2B1THYMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.6214e-02-0.4036image
chr12:123622831-123626143:-UCECGSVA_HALLMARK_KRAS_SIGNALING_DNEER2.4455e-020.4401image


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7. Enriched editing regions and drugs for EIF2B1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000111361.11,EIF2B1BLCALFM.A13EAG8.3182e-040.3480image
chr12:123622831-123626143:-BLCALFM.A13EER1.8199e-030.3278image
chr12:123622831-123626143:-BRCAEtoposideEER3.4581e-020.1119image
ENSG00000111361.11,EIF2B1BRCAEtoposideEAG3.3425e-020.1124image
ENSG00000111361.11,EIF2B1COADCyclopamineEAG1.0278e-020.3211image
chr12:123622831-123626143:-COADCyclopamineEER4.5613e-030.3556image
chr12:123622831-123626143:-ESCAJNK.9LEER2.2419e-03-0.2872image
ENSG00000111361.11,EIF2B1ESCAJNK.9LEAG7.0415e-03-0.2544image
ENSG00000111361.11,EIF2B1GBMAKT.inhibitor.VIIIEAG1.1558e-030.3914image
chr12:123622831-123626143:-GBMAKT.inhibitor.VIIIEER1.1558e-030.3914image
chr12:123622831-123626143:-HNSCGemcitabineEER2.4754e-02-0.4311image
ENSG00000111361.11,EIF2B1HNSCGemcitabineEAG2.5967e-02-0.4203image
chr12:123622831-123626143:-KIRCCI.1040EER3.0795e-05-0.3376image
ENSG00000111361.11,EIF2B1KIRCCI.1040EAG3.0795e-05-0.3376image
chr12:123622831-123626143:-KIRPIPA.3EER1.7195e-02-0.2579image
ENSG00000111361.11,EIF2B1KIRPIPA.3EAG1.7195e-02-0.2579image
ENSG00000111361.11,EIF2B1LAMLGemcitabineEAG7.7396e-03-0.2870image
chr12:123622831-123626143:-LAMLGemcitabineEER7.7396e-03-0.2870image
ENSG00000111361.11,EIF2B1LGGDoxorubicinEAG2.8181e-020.1336image
chr12:123622831-123626143:-LGGDoxorubicinEER2.8181e-020.1336image
ENSG00000111361.11,EIF2B1LUADCGP.60474EAG2.5368e-02-0.1720image
chr12:123622831-123626143:-LUADCGP.60474EER2.5368e-02-0.1720image
ENSG00000111361.11,EIF2B1LUSCElesclomolEAG7.8819e-04-0.2440image
chr12:123622831-123626143:-LUSCElesclomolEER7.8819e-04-0.2440image
ENSG00000111361.11,EIF2B1MESOCGP.082996EAG1.1138e-02-0.5302image
chr12:123622831-123626143:-MESOCGP.082996EER1.1138e-02-0.5302image
chr12:123622831-123626143:-OVMG.132EER8.6471e-03-0.2227image
ENSG00000111361.11,EIF2B1OVMG.132EAG6.8515e-03-0.2268image
chr12:123622831-123626143:-PAADCamptothecinEER1.8964e-02-0.3447image
ENSG00000111361.11,EIF2B1PAADCamptothecinEAG1.8964e-02-0.3447image
ENSG00000111361.11,EIF2B1READBIBW2992EAG3.8353e-03-0.5784image
chr12:123622831-123626143:-READBIBW2992EER3.8353e-03-0.5784image
ENSG00000111361.11,EIF2B1SARCGNF.2EAG6.6162e-040.5043image
chr12:123622831-123626143:-SARCGNF.2EER6.6162e-040.5043image
ENSG00000111361.11,EIF2B1SKCMCCT007093EAG4.2644e-020.2084image
chr12:123622831-123626143:-SKCMCCT007093EER3.6795e-020.2146image
chr12:123622831-123626143:-STADABT.263EER1.6741e-030.2512image
ENSG00000111361.11,EIF2B1STADABT.263EAG9.6740e-040.2592image
chr12:123622831-123626143:-TGCTBMS.536924EER1.6656e-02-0.3031image
ENSG00000111361.11,EIF2B1TGCTBMS.536924EAG1.6656e-02-0.3031image
chr12:123622831-123626143:-THCAKIN001.135EER5.3528e-030.2220image
ENSG00000111361.11,EIF2B1THCAKIN001.135EAG5.3528e-030.2220image
chr12:123622831-123626143:-THYMGSK.650394EER6.3787e-03-0.4523image
ENSG00000111361.11,EIF2B1THYMGSK.650394EAG6.3787e-03-0.4523image
chr12:123622831-123626143:-UCECCamptothecinEER7.8000e-030.5098image
ENSG00000111361.11,EIF2B1UCECCamptothecinEAG1.0092e-020.4864image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType