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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: PLBD2 (ImmuneEditome ID:196463)

1. Gene summary of enriched editing regions for PLBD2

check button Gene summary
Gene informationGene symbol

PLBD2

Gene ID

196463

GeneSynonymsP76
GeneCytomap

12q24.13

GeneTypeprotein-coding
GeneDescriptionputative phospholipase B-like 2|76 kDa protein|LAMA-like protein 2|PLB homolog 2|lamina ancestor homolog 2|mannose-6-phosphate protein associated protein p76|phospholipase B domain-containing protein 2|phospholipase B-like 2 32 kDa form|phospholipase B-like 2 45 kDa form
GeneModificationdate20230329
UniprotIDQ8NHP8;H0YIX0
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr12:113367580-113368033:+ENST00000280800.4ENSG00000151176.6PLBD2intronicAluSz,AluSz6chr12:113367580-113368033:+.alignment
chr12:113367580-113368033:+ENST00000545182.5ENSG00000151176.6PLBD2intronicAluSz,AluSz6chr12:113367580-113368033:+.alignment
chr12:113367580-113368033:+ENST00000548997.1ENSG00000151176.6PLBD2intronicAluSz,AluSz6chr12:113367580-113368033:+.alignment
chr12:113379005-113379277:+ENST00000280800.4ENSG00000151176.6PLBD2intronicAluSzchr12:113379005-113379277:+.alignment
chr12:113379005-113379277:+ENST00000545182.5ENSG00000151176.6PLBD2intronicAluSzchr12:113379005-113379277:+.alignment
chr12:113389784-113391202:+ENST00000280800.4ENSG00000151176.6PLBD2UTR3(CCAT)n,AluSzchr12:113389784-113391202:+.alignment


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2. Tumor-specific enriched editing regions for PLBD2


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr12:113389784-113391202:+BRCAEER1.4364e-20image
ENSG00000151176.6,PLBD2BRCAEAG6.3605e-21image
chr12:113389784-113391202:+COADEER1.7225e-07image
ENSG00000151176.6,PLBD2COADEAG1.3453e-07image
chr12:113389784-113391202:+HNSCEER3.7885e-19image
ENSG00000151176.6,PLBD2HNSCEAG3.8148e-19image
ENSG00000151176.6,PLBD2KICHEAG1.2897e-10image
chr12:113389784-113391202:+KIRCEER6.5094e-05image
ENSG00000151176.6,PLBD2KIRCEAG6.7176e-05image
chr12:113389784-113391202:+LUADEER1.1100e-02image
ENSG00000151176.6,PLBD2LUADEAG8.9277e-03image
chr12:113389784-113391202:+LUSCEER2.0808e-04image
ENSG00000151176.6,PLBD2LUSCEAG2.0264e-04image
chr12:113389784-113391202:+STADEER4.2694e-02image
ENSG00000151176.6,PLBD2STADEAG3.6022e-02image
chr12:113389784-113391202:+THCAEER3.4747e-03image
ENSG00000151176.6,PLBD2THCAEAG3.5069e-03image
chr12:113389784-113391202:+UCECEER5.2976e-08image
ENSG00000151176.6,PLBD2UCECEAG2.8149e-08image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr12:113389784-113391202:+KIRCPathEER1.2828e-022.2503e-030.1326image
ENSG00000151176.6,PLBD2KIRCPathEAG1.2768e-022.2611e-030.1325image
chr12:113389784-113391202:+PAADPathEER1.1986e-022.4550e-020.1699image
ENSG00000151176.6,PLBD2PAADPathEAG1.1218e-022.3592e-020.1711image
ENSG00000151176.6,PLBD2THCAPathEAG3.5356e-066.0262e-050.1786image
chr12:113389784-113391202:+THCAPathEER3.5611e-066.1225e-050.1784image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for PLBD2


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr12:113389784-113391202:+BLCAEERENSG00000134470,IL15RA0.63898.7675e-393.3710e-470.6447imageNNOP56IL15RAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr12:113389784-113391202:+BLCAEERENSG00000204267,TAP20.63918.7675e-394.7448e-500.6596imageNNOP56TAP2T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr12:113389784-113391202:+BLCAEERENSG00000025708,TYMP0.62277.7447e-373.0355e-410.6108imageNNTYMPT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr12:113389784-113391202:+BLCAEERENSG00000154451,GBP50.62419.8884e-372.2261e-190.4344imageNNOP56GBP5T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr12:113389784-113391202:+BLCAEERENSG00000197646,PDCD1LG20.61161.5280e-361.0154e-200.4487imageNNPDCD1LG2T_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr12:113389784-113391202:+BLCAEERENSG00000234745,HLA-B0.61984.5651e-364.2626e-480.6495imageNNOP56HLA-BT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr12:113389784-113391202:+BLCAEERENSG00000240065,PSMB90.61608.8495e-367.0697e-430.6205imageNNPSMB9T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr12:113389784-113391202:+BLCAEERENSG00000114013,CD860.61068.8495e-361.8659e-320.5518imageNNOP56CD86T_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr12:113389784-113391202:+BLCAEERENSG00000168394,TAP10.61304.5802e-351.0444e-430.6253imageNNOP56TAP1T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr12:113389784-113391202:+BLCAEERENSG00000156587,UBE2L60.61215.8586e-355.8876e-430.6210imageNNOP56NAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE

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4. Enriched editing regions and immune related splicing for PLBD2


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000151176.6,PLBD2
BLCAEAGIRENSG00000185482.3chr1257244314:57244366:57244536:57244564-0.38454.2546e-153.1403e-18-0.4694imageNADAR;BCCIP;CELF2;CNBP;CPSF6;CSTF2T;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPU;HNRNPUL1;IGF2BP2;ILF3;KHDRBS1;LIN28B;LSM11;NOP56;NOP58;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;SAFB2;SLTM;SND1;SRSF1;TAF15;TARDBP;TRA2A;U2AF1;U2AF2NAT_cells_CD4_memory_activatedGSVA_HALLMARK_COMPLEMENT
ENSG00000151176.6,PLBD2
BLCAEAGIRENSG00000196998.11chrX49076644:49076753:49077642:49077747-0.34213.0175e-092.9298e-16-0.4093imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;YTHDC1;YTHDF1;YWHAGNAT_cells_CD4_memory_activatedGSVA_HALLMARK_APOPTOSIS
chr12:113389784-113391202:+
BLCAEERIRENSG00000076662.5chr1910333775:10334782:10335065:10335353-0.35365.6880e-111.8305e-15-0.4106imageNNICAM3T_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr12:113389784-113391202:+
BLCAEERIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.57328.5368e-299.2204e-43-0.6205imageNNOP56PRKCSHMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr12:113389784-113391202:+
BLCAEERIRENSG00000139278.5chr1275495576:75495662:75498693:75498717-0.51104.0232e-231.0986e-30-0.5389imageNNOP56NAMacrophages_M1GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr12:113389784-113391202:+
BLCAEERIRENSG00000077454.11chr7100574010:100574356:100575704:100575782-0.52105.0072e-234.2106e-28-0.5181imageNNOP56NAT_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr12:113389784-113391202:+
BLCAEERIRENSG00000139278.5chr1275495576:75498720:75498823:75503853-0.50348.7032e-228.0494e-31-0.5406imageNNOP56NADendritic_cells_activatedGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr12:113389784-113391202:+
BLCAEERIRENSG00000184922.9chr1745242340:45244244:45244818:45244899-0.48516.0197e-211.3014e-16-0.4133imageNNOP56NAT_cells_CD4_naiveGSVA_HALLMARK_IL2_STAT5_SIGNALING
chr12:113389784-113391202:+
BLCAEERIRENSG00000076928.13chr1941897314:41898113:41898441:41898587-0.47491.0773e-202.6860e-28-0.5403imageNNOP56NAT_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr12:113389784-113391202:+
BLCAEERIRENSG00000111641.6chr126566100:6566324:6566528:6566559-0.34889.4857e-111.8629e-14-0.4016imageNNOP56NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MTORC1_SIGNALING

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5. Enriched editing regions and immune infiltration for PLBD2


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr12:113389784-113391202:+ACCEERT_cells_CD4_memory_activated1.2541e-040.4367image
ENSG00000151176.6,PLBD2ACCEAGT_cells_CD4_memory_activated1.2541e-040.4367image
chr12:113389784-113391202:+BLCAEERT_cells_CD4_memory_activated1.6719e-210.4568image
ENSG00000151176.6,PLBD2BLCAEAGT_cells_CD4_memory_activated1.7339e-210.4567image
chr12:113389784-113391202:+BRCAEERT_cells_CD4_memory_activated4.9445e-130.2171image
ENSG00000151176.6,PLBD2BRCAEAGT_cells_CD4_memory_activated4.8806e-130.2172image
chr12:113389784-113391202:+CESCEERT_cells_CD4_memory_resting1.7505e-07-0.2956image
ENSG00000151176.6,PLBD2CESCEAGT_cells_CD4_memory_resting1.7873e-07-0.2954image
chr12:113389784-113391202:+CHOLEERT_cells_CD4_naive2.2781e-020.3840image
ENSG00000151176.6,PLBD2CHOLEAGT_cells_CD4_naive4.7965e-020.3367image
chr12:113389784-113391202:+COADEERNeutrophils3.8856e-050.2472image
ENSG00000151176.6,PLBD2COADEAGNeutrophils3.1675e-050.2494image
chr12:113389784-113391202:+DLBCEERMacrophages_M14.1452e-060.6101image
ENSG00000151176.6,PLBD2DLBCEAGMacrophages_M14.1452e-060.6101image
chr12:113389784-113391202:+ESCAEERT_cells_regulatory_(Tregs)1.7807e-03-0.2444image
ENSG00000151176.6,PLBD2ESCAEAGT_cells_regulatory_(Tregs)1.8056e-03-0.2441image
chr12:113389784-113391202:+GBMEERMacrophages_M02.9792e-05-0.3237image
ENSG00000151176.6,PLBD2GBMEAGMacrophages_M02.9435e-05-0.3239image
chr12:113389784-113391202:+HNSCEERMacrophages_M17.2798e-120.3010image
ENSG00000151176.6,PLBD2HNSCEAGMacrophages_M16.9902e-120.3012image
ENSG00000151176.6,PLBD2KICHEAGB_cells_memory3.4765e-020.2906image
chr12:113389784-113391202:+KIRCEERT_cells_CD85.5663e-070.2518image
ENSG00000151176.6,PLBD2KIRCEAGT_cells_CD85.6126e-070.2517image
chr12:113389784-113391202:+KIRPEERT_cells_CD4_memory_resting7.9103e-08-0.3104image
ENSG00000151176.6,PLBD2KIRPEAGT_cells_CD4_memory_resting7.5178e-08-0.3109image
chr12:113389784-113391202:+LAMLEERT_cells_follicular_helper2.0750e-030.2698image
ENSG00000151176.6,PLBD2LAMLEAGT_cells_follicular_helper2.2279e-030.2680image
chr12:113389784-113391202:+LGGEERT_cells_CD4_naive3.8898e-07-0.2483image
ENSG00000151176.6,PLBD2LGGEAGT_cells_CD4_naive3.8792e-07-0.2484image
chr12:113389784-113391202:+LIHCEERMacrophages_M15.5698e-070.2557image
ENSG00000151176.6,PLBD2LIHCEAGMacrophages_M15.5651e-070.2557image
chr12:113389784-113391202:+LUADEERT_cells_CD4_memory_activated3.2488e-070.2228image
ENSG00000151176.6,PLBD2LUADEAGT_cells_CD4_memory_activated5.4267e-070.2186image
chr12:113389784-113391202:+LUSCEERT_cells_CD4_memory_activated3.9100e-100.2765image
ENSG00000151176.6,PLBD2LUSCEAGT_cells_CD4_memory_activated4.1215e-100.2761image
chr12:113389784-113391202:+MESOEERT_cells_CD83.1851e-040.3878image
ENSG00000151176.6,PLBD2MESOEAGT_cells_CD83.1851e-040.3878image
chr12:113389784-113391202:+OVEERMacrophages_M15.0265e-070.2910image
ENSG00000151176.6,PLBD2OVEAGMacrophages_M14.8865e-070.2912image
chr12:113389784-113391202:+PAADEERNK_cells_activated1.1151e-02-0.1904image
ENSG00000151176.6,PLBD2PAADEAGNK_cells_activated1.1140e-02-0.1904image
chr12:113389784-113391202:+PCPGEERT_cells_regulatory_(Tregs)3.0250e-060.3418image
ENSG00000151176.6,PLBD2PCPGEAGT_cells_regulatory_(Tregs)3.5950e-060.3393image
chr12:113389784-113391202:+PRADEERT_cells_regulatory_(Tregs)2.5659e-050.1878image
ENSG00000151176.6,PLBD2PRADEAGT_cells_regulatory_(Tregs)2.5725e-050.1878image
chr12:113389784-113391202:+READEERT_cells_CD4_memory_activated1.3922e-02-0.2516image
ENSG00000151176.6,PLBD2READEAGT_cells_CD4_memory_activated1.3922e-02-0.2516image
chr12:113389784-113391202:+SARCEERMacrophages_M12.5522e-040.2267image
ENSG00000151176.6,PLBD2SARCEAGMacrophages_M12.5604e-040.2266image
chr12:113389784-113391202:+SKCMEERT_cells_CD84.1114e-170.3769image
ENSG00000151176.6,PLBD2SKCMEAGT_cells_CD84.1420e-170.3769image
chr12:113389784-113391202:+STADEERT_cells_CD84.4132e-060.2352image
ENSG00000151176.6,PLBD2STADEAGT_cells_CD81.7197e-060.2447image
chr12:113389784-113391202:+TGCTEERMacrophages_M22.5190e-17-0.6140image
ENSG00000151176.6,PLBD2TGCTEAGMacrophages_M22.5025e-17-0.6140image
chr12:113389784-113391202:+THCAEERT_cells_regulatory_(Tregs)1.4656e-110.2959image
ENSG00000151176.6,PLBD2THCAEAGT_cells_regulatory_(Tregs)1.4401e-110.2960image
chr12:113389784-113391202:+THYMEERT_cells_gamma_delta1.2358e-040.3461image
ENSG00000151176.6,PLBD2THYMEAGT_cells_gamma_delta1.2358e-040.3461image
chr12:113389784-113391202:+UCECEERDendritic_cells_activated1.0438e-020.1943image
ENSG00000151176.6,PLBD2UCECEAGDendritic_cells_activated9.3458e-030.1960image
chr12:113389784-113391202:+UCSEERT_cells_CD4_memory_activated2.2340e-020.3163image
ENSG00000151176.6,PLBD2UCSEAGT_cells_CD4_memory_activated2.2340e-020.3163image
chr12:113389784-113391202:+UVMEERT_cells_CD82.3944e-040.3997image
ENSG00000151176.6,PLBD2UVMEAGT_cells_CD82.3944e-040.3997image


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6. Enriched editing regions and immune gene sets for PLBD2


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr12:113389784-113391202:+BLCAEER2.7763e-06image8.3942e-200.4390image
ENSG00000151176.6,PLBD2BLCAEAG2.7379e-06image9.0729e-200.4386image
chr12:113389784-113391202:+HNSCEER5.9263e-04image1.7784e-050.1912image
ENSG00000151176.6,PLBD2HNSCEAG5.8834e-04image1.7905e-050.1911image
chr12:113389784-113391202:+LUSCEER5.7270e-05image2.5778e-090.2636image
ENSG00000151176.6,PLBD2LUSCEAG5.5965e-05image2.7387e-090.2632image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr12:113389784-113391202:+BLCAEER3.3406e-120.34292.5897e-030.15224.4214e-110.32561.0219e-180.4270image
ENSG00000151176.6,PLBD2BLCAEAG3.4711e-120.34272.5692e-030.15234.4146e-110.32561.1531e-180.4264image
chr12:113389784-113391202:+BRCAEER4.5472e-110.19824.0005e-070.15323.2831e-050.12588.6244e-100.1849image
ENSG00000151176.6,PLBD2BRCAEAG5.8072e-110.19724.4169e-070.15273.9317e-050.12451.1908e-090.1834image
chr12:113389784-113391202:+LIHCEER3.0024e-05-0.21431.5131e-09-0.30642.3245e-07-0.26391.5487e-020.1253image
ENSG00000151176.6,PLBD2LIHCEAG2.9605e-05-0.21451.4581e-09-0.30662.2834e-07-0.26401.5399e-020.1254image
chr12:113389784-113391202:+PAADEER1.9064e-040.27695.5753e-040.25691.8353e-040.27767.9897e-050.2921image
ENSG00000151176.6,PLBD2PAADEAG1.9492e-040.27655.7749e-040.25621.8677e-040.27738.0353e-050.2920image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000151176.6,PLBD2ACCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG7.4197e-040.3886image
chr12:113389784-113391202:+ACCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER7.4197e-040.3886image
ENSG00000151176.6,PLBD2BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.3749e-560.6907image
chr12:113389784-113391202:+BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.0369e-560.6913image
ENSG00000151176.6,PLBD2BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.0991e-910.5631image
chr12:113389784-113391202:+BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.7722e-920.5636image
chr12:113389784-113391202:+CESCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER9.0541e-310.5996image
ENSG00000151176.6,PLBD2CESCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG8.0991e-310.6000image
ENSG00000151176.6,PLBD2CHOLGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.8997e-020.3352image
chr12:113389784-113391202:+CHOLGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.5421e-020.3404image
ENSG00000151176.6,PLBD2COADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.4124e-120.4121image
chr12:113389784-113391202:+COADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER7.7239e-140.4334image
ENSG00000151176.6,PLBD2DLBCGSVA_HALLMARK_COMPLEMENTEAG1.8545e-080.7077image
chr12:113389784-113391202:+DLBCGSVA_HALLMARK_COMPLEMENTEER1.8545e-080.7077image
ENSG00000151176.6,PLBD2ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.2453e-100.4670image
chr12:113389784-113391202:+ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.4454e-100.4726image
ENSG00000151176.6,PLBD2GBMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG7.1427e-080.4102image
chr12:113389784-113391202:+GBMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER7.1648e-080.4102image
ENSG00000151176.6,PLBD2HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.1002e-560.6304image
chr12:113389784-113391202:+HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.4801e-560.6300image
chr12:113389784-113391202:+KIRCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.6703e-120.3495image
ENSG00000151176.6,PLBD2KIRCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.8221e-120.3490image
chr12:113389784-113391202:+KIRPGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER6.5294e-110.3731image
ENSG00000151176.6,PLBD2KIRPGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG6.3917e-110.3733image
chr12:113389784-113391202:+LAMLGSVA_HALLMARK_PEROXISOMEEER3.4882e-02-0.1867image
ENSG00000151176.6,PLBD2LAMLGSVA_HALLMARK_PEROXISOMEEAG3.9577e-02-0.1822image
chr12:113389784-113391202:+LGGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.1153e-390.5909image
ENSG00000151176.6,PLBD2LGGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.0878e-390.5910image
chr12:113389784-113391202:+LIHCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2068e-240.4968image
ENSG00000151176.6,PLBD2LIHCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.3173e-240.4965image
ENSG00000151176.6,PLBD2LUADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG5.4372e-230.4162image
chr12:113389784-113391202:+LUADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER4.5392e-230.4169image
chr12:113389784-113391202:+LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.2362e-460.5802image
ENSG00000151176.6,PLBD2LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG9.7331e-460.5795image
ENSG00000151176.6,PLBD2MESOGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.2025e-100.6304image
chr12:113389784-113391202:+MESOGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.2025e-100.6304image
ENSG00000151176.6,PLBD2OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG9.1779e-230.5354image
chr12:113389784-113391202:+OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.7690e-230.5368image
chr12:113389784-113391202:+PAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER8.1112e-110.4636image
ENSG00000151176.6,PLBD2PAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG8.4116e-110.4633image
chr12:113389784-113391202:+PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.3308e-170.5773image
ENSG00000151176.6,PLBD2PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.4845e-170.5753image
ENSG00000151176.6,PLBD2PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.7320e-310.4875image
chr12:113389784-113391202:+PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.5455e-310.4876image
ENSG00000151176.6,PLBD2READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.4448e-070.4908image
chr12:113389784-113391202:+READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.4448e-070.4908image
chr12:113389784-113391202:+SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.3290e-220.5525image
ENSG00000151176.6,PLBD2SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.3628e-220.5525image
chr12:113389784-113391202:+SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.0714e-340.5282image
ENSG00000151176.6,PLBD2SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.0093e-340.5284image
chr12:113389784-113391202:+STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.1099e-230.4877image
ENSG00000151176.6,PLBD2STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.6312e-230.4827image
chr12:113389784-113391202:+TGCTGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER1.6435e-170.6168image
ENSG00000151176.6,PLBD2TGCTGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.6358e-170.6168image
ENSG00000151176.6,PLBD2THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG3.2186e-340.5084image
chr12:113389784-113391202:+THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER3.4438e-340.5082image
ENSG00000151176.6,PLBD2THYMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.8621e-100.5397image
chr12:113389784-113391202:+THYMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.8621e-100.5397image
chr12:113389784-113391202:+UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.9840e-090.4362image
ENSG00000151176.6,PLBD2UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG9.3557e-060.3280image
chr12:113389784-113391202:+UCSGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.5824e-050.5482image
ENSG00000151176.6,PLBD2UCSGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.5824e-050.5482image
ENSG00000151176.6,PLBD2UVMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.3258e-100.6425image
chr12:113389784-113391202:+UVMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.3258e-100.6425image


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7. Enriched editing regions and drugs for PLBD2


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000151176.6,PLBD2ACCEHT.1864EAG2.6696e-040.4172image
chr12:113389784-113391202:+ACCEHT.1864EER2.6696e-040.4172image
chr12:113389784-113391202:+BLCACGP.60474EER9.9464e-39-0.5951image
ENSG00000151176.6,PLBD2BLCACGP.60474EAG1.1810e-38-0.5946image
ENSG00000151176.6,PLBD2BRCAEHT.1864EAG3.4017e-220.2883image
chr12:113389784-113391202:+BRCACGP.082996EER2.8590e-22-0.2888image
chr12:113389784-113391202:+CESCCI.1040EER6.9217e-23-0.5267image
ENSG00000151176.6,PLBD2CESCCI.1040EAG6.3124e-23-0.5271image
ENSG00000151176.6,PLBD2CHOLFH535EAG7.8213e-03-0.4422image
chr12:113389784-113391202:+CHOLFH535EER8.6955e-03-0.4368image
chr12:113389784-113391202:+COADAICAREER3.3854e-09-0.3494image
ENSG00000151176.6,PLBD2COADAICAREAG1.1777e-09-0.3582image
ENSG00000151176.6,PLBD2DLBCImatinibEAG1.0822e-05-0.5886image
chr12:113389784-113391202:+DLBCImatinibEER1.0822e-05-0.5886image
chr12:113389784-113391202:+ESCACGP.60474EER4.5101e-06-0.3525image
ENSG00000151176.6,PLBD2ESCACGP.60474EAG4.4779e-06-0.3526image
chr12:113389784-113391202:+GBMBIBW2992EER8.6613e-08-0.4078image
ENSG00000151176.6,PLBD2GBMBIBW2992EAG8.5066e-08-0.4081image
chr12:113389784-113391202:+HNSCCGP.60474EER5.5001e-25-0.4403image
ENSG00000151176.6,PLBD2HNSCCGP.60474EAG5.4049e-25-0.4404image
ENSG00000151176.6,PLBD2KICHCisplatinEAG7.7719e-04-0.4476image
chr12:113389784-113391202:+KIRCAZD.2281EER6.0728e-17-0.4098image
ENSG00000151176.6,PLBD2KIRCAZD.2281EAG6.0728e-17-0.4098image
ENSG00000151176.6,PLBD2KIRPAZD7762EAG1.8316e-16-0.4604image
chr12:113389784-113391202:+KIRPAZD7762EER2.0316e-16-0.4598image
chr12:113389784-113391202:+LAMLGefitinibEER6.8562e-03-0.2379image
ENSG00000151176.6,PLBD2LAMLGefitinibEAG5.1353e-03-0.2460image
chr12:113389784-113391202:+LGGBexaroteneEER8.0512e-26-0.4887image
ENSG00000151176.6,PLBD2LGGBexaroteneEAG7.9445e-26-0.4888image
chr12:113389784-113391202:+LIHCGSK.650394EER7.9032e-160.4008image
ENSG00000151176.6,PLBD2LIHCGSK.650394EAG7.5274e-160.4011image
ENSG00000151176.6,PLBD2LUADCI.1040EAG1.6293e-15-0.3413image
chr12:113389784-113391202:+LUADCI.1040EER1.6200e-15-0.3413image
ENSG00000151176.6,PLBD2LUSCCGP.60474EAG1.5737e-19-0.3910image
chr12:113389784-113391202:+LUSCCGP.60474EER1.5720e-19-0.3910image
ENSG00000151176.6,PLBD2MESOAxitinibEAG2.1735e-040.3975image
chr12:113389784-113391202:+MESOAxitinibEER2.1735e-040.3975image
ENSG00000151176.6,PLBD2OVCGP.60474EAG2.4570e-08-0.3212image
chr12:113389784-113391202:+OVCGP.60474EER2.5024e-08-0.3211image
chr12:113389784-113391202:+PAADBexaroteneEER4.0958e-09-0.4240image
ENSG00000151176.6,PLBD2PAADBexaroteneEAG4.0068e-09-0.4242image
ENSG00000151176.6,PLBD2PCPGBI.2536EAG1.9333e-060.3480image
chr12:113389784-113391202:+PCPGBI.2536EER1.8610e-060.3486image
chr12:113389784-113391202:+PRADAxitinibEER2.3095e-130.3212image
ENSG00000151176.6,PLBD2PRADAxitinibEAG2.2713e-130.3212image
ENSG00000151176.6,PLBD2READBIRB.0796EAG2.1739e-030.3108image
chr12:113389784-113391202:+READBIRB.0796EER2.1739e-030.3108image
ENSG00000151176.6,PLBD2SARCAG.014699EAG6.1826e-150.4619image
chr12:113389784-113391202:+SARCAG.014699EER6.2296e-150.4619image
chr12:113389784-113391202:+SKCMCI.1040EER7.6170e-15-0.3503image
ENSG00000151176.6,PLBD2SKCMCI.1040EAG7.5477e-15-0.3504image
chr12:113389784-113391202:+STADCI.1040EER3.2835e-14-0.3793image
ENSG00000151176.6,PLBD2STADCI.1040EAG6.7425e-14-0.3750image
chr12:113389784-113391202:+TGCTABT.888EER9.1206e-17-0.6053image
ENSG00000151176.6,PLBD2TGCTABT.888EAG8.7144e-17-0.6056image
ENSG00000151176.6,PLBD2THCACI.1040EAG2.8237e-37-0.5282image
chr12:113389784-113391202:+THCACI.1040EER2.9669e-37-0.5281image
ENSG00000151176.6,PLBD2THYMDoxorubicinEAG4.1637e-060.4094image
chr12:113389784-113391202:+THYMDoxorubicinEER4.1637e-060.4094image
chr12:113389784-113391202:+UCECABT.888EER2.7154e-04-0.2735image
ENSG00000151176.6,PLBD2UCECABT.888EAG5.6389e-04-0.2581image
chr12:113389784-113391202:+UCSCGP.60474EER1.5931e-04-0.5002image
ENSG00000151176.6,PLBD2UCSCGP.60474EAG1.5931e-04-0.5002image
ENSG00000151176.6,PLBD2UVMBortezomibEAG3.8180e-09-0.6008image
chr12:113389784-113391202:+UVMBortezomibEER3.8180e-09-0.6008image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType