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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: AHR (ImmuneEditome ID:196)

1. Gene summary of enriched editing regions for AHR

check button Gene summary
Gene informationGene symbol

AHR

Gene ID

196

GeneSynonymsRP85|bHLHe76
GeneCytomap

7p21.1

GeneTypeprotein-coding
GeneDescriptionaryl hydrocarbon receptor|AH-receptor|ah receptor|aromatic hydrocarbon receptor|class E basic helix-loop-helix protein 76
GeneModificationdate20230521
UniprotIDP35869;A0A024R9Z8;A0A2R8Y7G1
PubMed ID

37336251

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr7:17344636-17345270:+ENST00000242057.7ENSG00000106546.11AHRUTR3AluSc,AluSxchr7:17344636-17345270:+.alignment
chr7:17344636-17345270:+ENST00000463496.1ENSG00000106546.11AHRUTR3AluSc,AluSxchr7:17344636-17345270:+.alignment


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2. Tumor-specific enriched editing regions for AHR


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr7:17344636-17345270:+BRCAEER1.4135e-27image
ENSG00000106546.11,AHRBRCAEAG1.4023e-27image
chr7:17344636-17345270:+HNSCEER1.1581e-07image
ENSG00000106546.11,AHRHNSCEAG1.1718e-07image
chr7:17344636-17345270:+KICHEER1.8414e-03image
ENSG00000106546.11,AHRKICHEAG1.8414e-03image
chr7:17344636-17345270:+KIRPEER3.3132e-03image
ENSG00000106546.11,AHRKIRPEAG3.3132e-03image
chr7:17344636-17345270:+LIHCEER3.2975e-05image
ENSG00000106546.11,AHRLIHCEAG3.2284e-05image
chr7:17344636-17345270:+LUADEER3.0681e-05image
ENSG00000106546.11,AHRLUADEAG3.0681e-05image
chr7:17344636-17345270:+LUSCEER4.8255e-03image
ENSG00000106546.11,AHRLUSCEAG4.8255e-03image
chr7:17344636-17345270:+THCAEER1.7959e-03image
ENSG00000106546.11,AHRTHCAEAG1.7959e-03image
chr7:17344636-17345270:+UCECEER3.6814e-02image
ENSG00000106546.11,AHRUCECEAG3.6915e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000106546.11,AHRKIRPPathEAG1.1912e-036.1432e-040.2169image
chr7:17344636-17345270:+KIRPPathEER1.1912e-036.1432e-040.2169image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for AHR


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr7:17344636-17345270:+LIHCEERENSG00000162735,PEX190.44199.8698e-154.1619e-200.4562imageNBCCIP;DHX9;EIF4A3;FAM120A;HNRNPU;IGF2BP2;TAF15NAMast_cells_restingGSVA_HALLMARK_PEROXISOME
chr7:17344636-17345270:+LIHCEERENSG00000117601,SERPINC10.41434.1110e-147.5277e-180.4304imageNBCCIP;FAM120A;TAF15SERPINC1Mast_cells_restingGSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:17344636-17345270:+LIHCEERENSG00000143149,ALDH9A10.43045.4320e-144.6756e-160.4083imageNEIF4A3;FAM120A;HNRNPU;IGF2BP2;TAF15NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:17344636-17345270:+LIHCEERENSG00000173457,PPP1R14B-0.41421.0863e-124.6679e-17-0.4208imageNBCCIP;EIF4A3;FAM120A;HNRNPU;IGF2BP2;TAF15NAMacrophages_M0GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:17344636-17345270:+LIHCEERENSG00000179967,PPP1R14BP3-0.41181.5789e-124.2722e-16-0.4088imageNNNAMacrophages_M0GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:17344636-17345270:+LIHCEERENSG00000123838,C4BPA0.39248.4615e-121.4461e-150.4019imageNEIF4A3;TAF15C4BPAMast_cells_restingGSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:17344636-17345270:+SKCMEERENSG00000160710,ADAR0.40331.4040e-147.7362e-240.4529imageNBCCIP;DHX9;EIF4A3;FAM120A;HNRNPU;IGF2BP2;TAF15ADART_cells_CD8GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr7:17344636-17345270:+MESOEERENSG00000134574,DDB20.49633.2767e-022.8721e-050.4496imageNBCCIP;DHX9;EIF4A3;FAM120A;HNRNPU;IGF2BP2;TAF15NANeutrophilsGSVA_HALLMARK_P53_PATHWAY
chr7:17344636-17345270:+THYMEERENSG00000151470,C4orf330.31501.3523e-028.7884e-070.4624imageNEIF4A3;FAM120A;HNRNPU;IGF2BP2;TAF15NADendritic_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr7:17344636-17345270:+THYMEERENSG00000227540,RP11-152N13.50.25184.5181e-024.8815e-060.4331imageNEIF4A3;HNRNPU;IGF2BP2;TAF15NAT_cells_follicular_helperGSVA_HALLMARK_HEDGEHOG_SIGNALING
chr7:17344636-17345270:+LIHCEERENSG00000162735,PEX190.44199.8698e-154.1619e-200.4562imageNBCCIP;DHX9;EIF4A3;FAM120A;HNRNPU;IGF2BP2;TAF15NAMast_cells_restingGSVA_HALLMARK_PEROXISOME
chr7:17344636-17345270:+LIHCEERENSG00000117601,SERPINC10.41434.1110e-147.5277e-180.4304imageNBCCIP;FAM120A;TAF15SERPINC1Mast_cells_restingGSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:17344636-17345270:+LIHCEERENSG00000143149,ALDH9A10.43045.4320e-144.6756e-160.4083imageNEIF4A3;FAM120A;HNRNPU;IGF2BP2;TAF15NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:17344636-17345270:+LIHCEERENSG00000173457,PPP1R14B-0.41421.0863e-124.6679e-17-0.4208imageNBCCIP;EIF4A3;FAM120A;HNRNPU;IGF2BP2;TAF15NAMacrophages_M0GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:17344636-17345270:+LIHCEERENSG00000179967,PPP1R14BP3-0.41181.5789e-124.2722e-16-0.4088imageNNNAMacrophages_M0GSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:17344636-17345270:+LIHCEERENSG00000123838,C4BPA0.39248.4615e-121.4461e-150.4019imageNEIF4A3;TAF15C4BPAMast_cells_restingGSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:17344636-17345270:+SKCMEERENSG00000160710,ADAR0.40331.4040e-147.7362e-240.4529imageNBCCIP;DHX9;EIF4A3;FAM120A;HNRNPU;IGF2BP2;TAF15ADART_cells_CD8GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr7:17344636-17345270:+MESOEERENSG00000134574,DDB20.49633.2767e-022.8721e-050.4496imageNBCCIP;DHX9;EIF4A3;FAM120A;HNRNPU;IGF2BP2;TAF15NANeutrophilsGSVA_HALLMARK_P53_PATHWAY
chr7:17344636-17345270:+THYMEERENSG00000151470,C4orf330.31501.3523e-028.7884e-070.4624imageNEIF4A3;FAM120A;HNRNPU;IGF2BP2;TAF15NADendritic_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr7:17344636-17345270:+THYMEERENSG00000227540,RP11-152N13.50.25184.5181e-024.8815e-060.4331imageNEIF4A3;HNRNPU;IGF2BP2;TAF15NAT_cells_follicular_helperGSVA_HALLMARK_HEDGEHOG_SIGNALING

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4. Enriched editing regions and immune related splicing for AHR


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000106546.11,AHR
LIHCEAGMEXENSG00000131174.4chrX77899462:77899593:77901743:77901867:77901920:77902015:77902642:77902714-0.45194.1089e-151.1306e-20-0.4623imageNACIN1;AUH;BUD13;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHDRBS3;LARP4B;LIN28;LIN28A;LIN28B;MOV10;MSI2;NOP56;NOP58;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;ZNF184NAMast_cells_restingGSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:17344636-17345270:+
LIHCEERA5ENSG00000131174.4chrX77902642:77902714:77901798:77901867:77901798:77902015-0.46224.5079e-161.2674e-21-0.4723imageNDHX9;EIF4A3;FAM120A;HNRNPU;IGF2BP2;TAF15NAMast_cells_restingGSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:17344636-17345270:+
LIHCEERMEXENSG00000131174.4chrX77899462:77899593:77901743:77901867:77901920:77902015:77902642:77902714-0.45094.2734e-151.3858e-20-0.4613imageNDHX9;EIF4A3;FAM120A;HNRNPU;IGF2BP2;TAF15NAMast_cells_restingGSVA_HALLMARK_BILE_ACID_METABOLISM
ENSG00000106546.11,AHR
LIHCEAGA5ENSG00000131174.4chrX77902642:77902714:77901798:77901867:77901798:77902015-0.46304.1403e-161.0560e-21-0.4731imageNACIN1;AUH;BUD13;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHDRBS3;LARP4B;LIN28;LIN28A;LIN28B;MOV10;MSI2;NOP56;NOP58;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;ZNF184NAMast_cells_restingGSVA_HALLMARK_BILE_ACID_METABOLISM
chr7:17344636-17345270:+
SKCMEERIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.46701.9254e-191.6017e-21-0.4316imageNBCCIP;DHX9;EIF4A3;FAM120A;HNRNPU;IGF2BP2;TAF15PRKCSHT_cells_CD8GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000106546.11,AHR
SKCMEAGIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.46702.1682e-191.6017e-21-0.4316imageNACIN1;ADAR;ALYREF;AUH;BCCIP;BUD13;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DICER1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHDRBS3;LARP4B;LIN28;LIN28A;LIN28B;MOV10;MSI2;NOP56;NOP58;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM47;RBM5;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1;YTHDF2;ZNF184PRKCSHT_cells_CD8GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr7:17344636-17345270:+
TGCTEERA3ENSG00000159840.11chr7143382999:143383322:143387761:143387787:143384089:143387787-0.26252.2764e-024.6261e-06-0.4044imageNBCCIP;EIF4A3;FAM120A;HNRNPU;IGF2BP2;TAF15ZYXMacrophages_M2GSVA_HALLMARK_HYPOXIA
chr7:17344636-17345270:+
TGCTEERESENSG00000131236.12chr140040779:40040801:40041428:40041493:40059333:400594580.34542.7726e-033.0375e-070.4296imageNBCCIP;DHX9;EIF4A3;FAM120A;HNRNPU;IGF2BP2;TAF15CAP1Macrophages_M2GSVA_HALLMARK_MYOGENESIS
ENSG00000106546.11,AHR
TGCTEAGESENSG00000131236.12chr140040779:40040801:40041428:40041493:40059333:400594580.34542.3143e-033.0375e-070.4296imageNACIN1;ADAR;ALYREF;AUH;BCCIP;BUD13;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHDRBS3;LARP4B;LIN28;LIN28A;LIN28B;MBNL2;MOV10;MSI2;NOP56;NOP58;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;RBM5;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1;ZNF184CAP1Macrophages_M2GSVA_HALLMARK_MYOGENESIS
ENSG00000106546.11,AHR
TGCTEAGA3ENSG00000159840.11chr7143382999:143383322:143387761:143387787:143384089:143387787-0.26252.1248e-024.6261e-06-0.4044imageNACIN1;ADAR;AUH;BCCIP;BUD13;CNBP;CSTF2T;DDX54;DGCR8;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;LARP4B;LIN28;LIN28A;LIN28B;MBNL2;MOV10;MSI2;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM5;RC3H1;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1;ZNF184ZYXMacrophages_M2GSVA_HALLMARK_HYPOXIA

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5. Enriched editing regions and immune infiltration for AHR


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr7:17344636-17345270:+ACCEERMonocytes4.8705e-02-0.2436image
ENSG00000106546.11,AHRACCEAGMonocytes4.8705e-02-0.2436image
chr7:17344636-17345270:+BLCAEERT_cells_CD4_memory_activated1.0782e-120.3468image
ENSG00000106546.11,AHRBLCAEAGT_cells_CD4_memory_activated1.0782e-120.3468image
chr7:17344636-17345270:+BRCAEERMacrophages_M15.9246e-070.1522image
ENSG00000106546.11,AHRBRCAEAGMacrophages_M15.9346e-070.1522image
chr7:17344636-17345270:+CESCEERT_cells_CD87.3093e-030.1551image
ENSG00000106546.11,AHRCESCEAGT_cells_CD87.3093e-030.1551image
chr7:17344636-17345270:+CHOLEERT_cells_CD4_naive4.3880e-020.3427image
ENSG00000106546.11,AHRCHOLEAGT_cells_CD4_naive4.3880e-020.3427image
chr7:17344636-17345270:+COADEERMacrophages_M11.3068e-020.1520image
ENSG00000106546.11,AHRCOADEAGMacrophages_M11.3068e-020.1520image
chr7:17344636-17345270:+DLBCEERT_cells_gamma_delta7.2679e-030.3949image
ENSG00000106546.11,AHRDLBCEAGB_cells_naive5.7198e-03-0.4055image
chr7:17344636-17345270:+ESCAEERMacrophages_M12.4441e-030.2372image
ENSG00000106546.11,AHRESCAEAGMacrophages_M12.4441e-030.2372image
chr7:17344636-17345270:+GBMEERMacrophages_M03.6324e-03-0.2294image
ENSG00000106546.11,AHRGBMEAGMacrophages_M03.6973e-03-0.2290image
chr7:17344636-17345270:+HNSCEERMacrophages_M11.1321e-050.1961image
ENSG00000106546.11,AHRHNSCEAGMacrophages_M11.1197e-050.1962image
chr7:17344636-17345270:+KIRCEERT_cells_gamma_delta5.5530e-030.1416image
ENSG00000106546.11,AHRKIRCEAGT_cells_gamma_delta5.5530e-030.1416image
chr7:17344636-17345270:+KIRPEERB_cells_naive2.1055e-040.2229image
ENSG00000106546.11,AHRKIRPEAGB_cells_naive2.1055e-040.2229image
chr7:17344636-17345270:+LAMLEERT_cells_regulatory_(Tregs)1.8298e-050.5389image
ENSG00000106546.11,AHRLAMLEAGT_cells_regulatory_(Tregs)1.8298e-050.5389image
chr7:17344636-17345270:+LGGEERT_cells_CD4_naive6.1130e-030.1601image
ENSG00000106546.11,AHRLGGEAGT_cells_CD4_naive6.0027e-030.1604image
chr7:17344636-17345270:+LIHCEERMacrophages_M16.6922e-080.2783image
ENSG00000106546.11,AHRLIHCEAGMacrophages_M16.6217e-080.2784image
chr7:17344636-17345270:+LUADEERT_cells_CD4_memory_activated6.9790e-060.1973image
ENSG00000106546.11,AHRLUADEAGT_cells_CD4_memory_activated6.9790e-060.1973image
chr7:17344636-17345270:+LUSCEERT_cells_CD4_memory_activated1.1551e-110.2982image
ENSG00000106546.11,AHRLUSCEAGT_cells_CD4_memory_activated1.1551e-110.2982image
chr7:17344636-17345270:+MESOEERMacrophages_M14.6699e-030.3132image
ENSG00000106546.11,AHRMESOEAGMacrophages_M14.6699e-030.3132image
chr7:17344636-17345270:+OVEERT_cells_follicular_helper2.2632e-030.1799image
ENSG00000106546.11,AHROVEAGT_cells_follicular_helper1.7659e-030.1841image
chr7:17344636-17345270:+PAADEERDendritic_cells_activated6.2508e-040.2540image
ENSG00000106546.11,AHRPAADEAGDendritic_cells_activated6.2508e-040.2540image
chr7:17344636-17345270:+PCPGEERT_cells_regulatory_(Tregs)2.1799e-030.2806image
ENSG00000106546.11,AHRPCPGEAGT_cells_regulatory_(Tregs)2.1799e-030.2806image
chr7:17344636-17345270:+PRADEERMacrophages_M04.7984e-020.0943image
ENSG00000106546.11,AHRPRADEAGMacrophages_M04.7732e-020.0944image
chr7:17344636-17345270:+READEERB_cells_memory3.3013e-020.2225image
ENSG00000106546.11,AHRREADEAGB_cells_memory3.3013e-020.2225image
chr7:17344636-17345270:+SARCEERT_cells_CD4_naive3.9188e-02-0.1327image
ENSG00000106546.11,AHRSARCEAGT_cells_CD4_naive3.9188e-02-0.1327image
chr7:17344636-17345270:+SKCMEERT_cells_CD82.8026e-110.3090image
ENSG00000106546.11,AHRSKCMEAGT_cells_CD82.8026e-110.3090image
chr7:17344636-17345270:+STADEERMacrophages_M11.7239e-020.1238image
ENSG00000106546.11,AHRSTADEAGT_cells_CD81.8613e-020.1223image
chr7:17344636-17345270:+TGCTEERMacrophages_M25.5103e-03-0.2318image
ENSG00000106546.11,AHRTGCTEAGMacrophages_M25.5103e-03-0.2318image
chr7:17344636-17345270:+THCAEERT_cells_regulatory_(Tregs)3.3615e-030.1306image
ENSG00000106546.11,AHRTHCAEAGT_cells_regulatory_(Tregs)3.3615e-030.1306image
chr7:17344636-17345270:+THYMEERT_cells_follicular_helper2.9729e-020.2143image
ENSG00000106546.11,AHRTHYMEAGT_cells_follicular_helper2.9729e-020.2143image
chr7:17344636-17345270:+UCECEERT_cells_regulatory_(Tregs)1.4111e-020.1902image
ENSG00000106546.11,AHRUCECEAGT_cells_regulatory_(Tregs)1.4111e-020.1902image


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6. Enriched editing regions and immune gene sets for AHR


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr7:17344636-17345270:+BLCAEER5.5128e-04image7.5574e-060.2223image
ENSG00000106546.11,AHRBLCAEAG5.5128e-04image7.5574e-060.2223image
chr7:17344636-17345270:+HNSCEER5.1500e-04image1.5926e-020.1084image
ENSG00000106546.11,AHRHNSCEAG5.0946e-04image1.5503e-020.1088image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr7:17344636-17345270:+BLCAEER2.0381e-090.29478.5569e-060.22101.1400e-070.26207.3016e-070.2452image
ENSG00000106546.11,AHRBLCAEAG2.0381e-090.29478.5569e-060.22101.1400e-070.26207.3016e-070.2452image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000106546.11,AHRBLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG6.3271e-170.4024image
chr7:17344636-17345270:+BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER6.3271e-170.4024image
chr7:17344636-17345270:+BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.0506e-210.2840image
ENSG00000106546.11,AHRBRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.0202e-210.2840image
ENSG00000106546.11,AHRCESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.4024e-120.3855image
chr7:17344636-17345270:+CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.4024e-120.3855image
ENSG00000106546.11,AHRCHOLGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.5148e-020.4074image
chr7:17344636-17345270:+CHOLGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.5148e-020.4074image
ENSG00000106546.11,AHRCOADGSVA_HALLMARK_DNA_REPAIREAG2.2869e-02-0.1395image
chr7:17344636-17345270:+COADGSVA_HALLMARK_DNA_REPAIREER2.2869e-02-0.1395image
ENSG00000106546.11,AHRDLBCGSVA_HALLMARK_G2M_CHECKPOINTEAG3.3065e-03-0.4286image
chr7:17344636-17345270:+DLBCGSVA_HALLMARK_G2M_CHECKPOINTEER1.5383e-02-0.3592image
ENSG00000106546.11,AHRESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.1313e-050.3282image
chr7:17344636-17345270:+ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.1313e-050.3282image
chr7:17344636-17345270:+GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER8.8049e-050.3059image
ENSG00000106546.11,AHRGBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.0200e-040.3033image
ENSG00000106546.11,AHRHNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.9446e-190.3855image
chr7:17344636-17345270:+HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.4733e-190.3859image
chr7:17344636-17345270:+KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.0409e-030.1672image
ENSG00000106546.11,AHRKIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.0409e-030.1672image
ENSG00000106546.11,AHRKIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.1870e-030.1850image
chr7:17344636-17345270:+KIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.1870e-030.1850image
ENSG00000106546.11,AHRLAMLGSVA_HALLMARK_MTORC1_SIGNALINGEAG5.3410e-05-0.5127image
chr7:17344636-17345270:+LAMLGSVA_HALLMARK_MTORC1_SIGNALINGEER5.3410e-05-0.5127image
ENSG00000106546.11,AHRLGGGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG5.9789e-04-0.1997image
chr7:17344636-17345270:+LGGGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER6.1833e-04-0.1992image
chr7:17344636-17345270:+LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEER4.1674e-170.4215image
ENSG00000106546.11,AHRLIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.3477e-170.4226image
ENSG00000106546.11,AHRLUADGSVA_HALLMARK_E2F_TARGETSEAG4.0675e-100.2720image
chr7:17344636-17345270:+LUADGSVA_HALLMARK_E2F_TARGETSEER4.0675e-100.2720image
ENSG00000106546.11,AHRLUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2826e-150.3483image
chr7:17344636-17345270:+LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2826e-150.3483image
ENSG00000106546.11,AHRMESOGSVA_HALLMARK_P53_PATHWAYEAG5.9719e-030.3048image
chr7:17344636-17345270:+MESOGSVA_HALLMARK_P53_PATHWAYEER5.9719e-030.3048image
chr7:17344636-17345270:+OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.6173e-100.3664image
ENSG00000106546.11,AHROVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.0236e-110.3798image
ENSG00000106546.11,AHRPAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.1411e-020.1892image
chr7:17344636-17345270:+PAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.1411e-020.1892image
ENSG00000106546.11,AHRPCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.2484e-030.2514image
chr7:17344636-17345270:+PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.2484e-030.2514image
chr7:17344636-17345270:+PRADGSVA_HALLMARK_KRAS_SIGNALING_DNEER4.8593e-03-0.1340image
ENSG00000106546.11,AHRPRADGSVA_HALLMARK_KRAS_SIGNALING_DNEAG4.8539e-03-0.1340image
chr7:17344636-17345270:+READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER8.4506e-060.4458image
ENSG00000106546.11,AHRREADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG8.4506e-060.4458image
ENSG00000106546.11,AHRSARCGSVA_HALLMARK_ANGIOGENESISEAG1.2566e-02-0.1602image
chr7:17344636-17345270:+SARCGSVA_HALLMARK_ANGIOGENESISEER1.2566e-02-0.1602image
ENSG00000106546.11,AHRSKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG8.1522e-180.3926image
chr7:17344636-17345270:+SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER8.1522e-180.3926image
chr7:17344636-17345270:+STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.0742e-090.2997image
ENSG00000106546.11,AHRSTADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.1721e-090.2995image
chr7:17344636-17345270:+TGCTGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER1.0072e-04-0.3205image
ENSG00000106546.11,AHRTGCTGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG1.0072e-04-0.3205image
ENSG00000106546.11,AHRTHCAGSVA_HALLMARK_E2F_TARGETSEAG2.0436e-030.1373image
chr7:17344636-17345270:+THCAGSVA_HALLMARK_E2F_TARGETSEER2.0436e-030.1373image
ENSG00000106546.11,AHRTHYMGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.2616e-02-0.2450image
chr7:17344636-17345270:+THYMGSVA_HALLMARK_NOTCH_SIGNALINGEER1.2616e-02-0.2450image
chr7:17344636-17345270:+UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.2455e-030.2077image
ENSG00000106546.11,AHRUCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.2455e-030.2077image
chr7:17344636-17345270:+UCSGSVA_HALLMARK_DNA_REPAIREER1.7653e-040.5108image
ENSG00000106546.11,AHRUCSGSVA_HALLMARK_DNA_REPAIREAG2.0579e-040.5063image


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7. Enriched editing regions and drugs for AHR


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr7:17344636-17345270:+ACCAICAREER2.5736e-02-0.2745image
ENSG00000106546.11,AHRACCAICAREAG2.5736e-02-0.2745image
ENSG00000106546.11,AHRBLCAFH535EAG1.4215e-230.4729image
chr7:17344636-17345270:+BLCAFH535EER1.4215e-230.4729image
ENSG00000106546.11,AHRBRCAJNK.Inhibitor.VIIIEAG1.5027e-11-0.2047image
chr7:17344636-17345270:+BRCAJNK.Inhibitor.VIIIEER1.3950e-11-0.2050image
chr7:17344636-17345270:+CESCAZD6244EER7.0961e-06-0.2568image
ENSG00000106546.11,AHRCESCAZD6244EAG7.0961e-06-0.2568image
ENSG00000106546.11,AHRCHOLBleomycinEAG2.8028e-020.3714image
chr7:17344636-17345270:+CHOLBleomycinEER2.8028e-020.3714image
ENSG00000106546.11,AHRCOADAICAREAG2.1202e-04-0.2253image
chr7:17344636-17345270:+COADAICAREER2.1202e-04-0.2253image
ENSG00000106546.11,AHRDLBCAZD.2281EAG1.7425e-03-0.4538image
chr7:17344636-17345270:+DLBCAZ628EER1.4027e-03-0.4619image
ENSG00000106546.11,AHRESCACGP.60474EAG6.6945e-04-0.2653image
chr7:17344636-17345270:+ESCACGP.60474EER6.6945e-04-0.2653image
chr7:17344636-17345270:+GBMATRAEER2.3556e-05-0.3286image
ENSG00000106546.11,AHRGBMATRAEAG2.6825e-05-0.3264image
ENSG00000106546.11,AHRHNSCFH535EAG1.5984e-080.2508image
chr7:17344636-17345270:+HNSCFH535EER1.5725e-080.2509image
ENSG00000106546.11,AHRKIRCLFM.A13EAG3.0610e-040.1837image
chr7:17344636-17345270:+KIRCLFM.A13EER3.0610e-040.1837image
chr7:17344636-17345270:+KIRPGW.441756EER1.9130e-05-0.2560image
ENSG00000106546.11,AHRKIRPGW.441756EAG1.9130e-05-0.2560image
ENSG00000106546.11,AHRLAMLJNK.Inhibitor.VIIIEAG2.0665e-030.4031image
chr7:17344636-17345270:+LAMLJNK.Inhibitor.VIIIEER2.0665e-030.4031image
ENSG00000106546.11,AHRLGGJW.7.52.1EAG4.4741e-050.2365image
chr7:17344636-17345270:+LGGJW.7.52.1EER4.9178e-050.2352image
chr7:17344636-17345270:+LIHCBleomycinEER8.2109e-130.3668image
ENSG00000106546.11,AHRLIHCBleomycinEAG7.5312e-130.3674image
chr7:17344636-17345270:+LUADCMKEER9.7789e-06-0.1942image
ENSG00000106546.11,AHRLUADCMKEAG9.7789e-06-0.1942image
ENSG00000106546.11,AHRLUSCGemcitabineEAG1.9078e-05-0.1905image
chr7:17344636-17345270:+LUSCGemcitabineEER1.9078e-05-0.1905image
ENSG00000106546.11,AHRMESODMOGEAG3.5066e-02-0.2360image
chr7:17344636-17345270:+MESODMOGEER3.5066e-02-0.2360image
chr7:17344636-17345270:+OVBX.795EER2.7657e-060.2731image
ENSG00000106546.11,AHROVBX.795EAG3.8934e-060.2691image
ENSG00000106546.11,AHRPAADGSK.650394EAG2.7072e-040.2743image
chr7:17344636-17345270:+PAADGSK.650394EER2.7072e-040.2743image
ENSG00000106546.11,AHRPCPGAxitinibEAG1.5347e-030.2897image
chr7:17344636-17345270:+PCPGAxitinibEER1.5347e-030.2897image
chr7:17344636-17345270:+READCytarabineEER1.7230e-020.2478image
ENSG00000106546.11,AHRREADCytarabineEAG1.7230e-020.2478image
ENSG00000106546.11,AHRSARCAZ628EAG1.3111e-030.2054image
chr7:17344636-17345270:+SARCAZ628EER1.3111e-030.2054image
ENSG00000106546.11,AHRSKCMJNK.9LEAG1.5949e-05-0.2032image
chr7:17344636-17345270:+SKCMJNK.9LEER1.5949e-05-0.2032image
chr7:17344636-17345270:+STADAZD.2281EER1.0817e-05-0.2274image
ENSG00000106546.11,AHRSTADAZD.2281EAG1.0665e-05-0.2276image
chr7:17344636-17345270:+TGCTLFM.A13EER1.9215e-040.3080image
ENSG00000106546.11,AHRTGCTLFM.A13EAG1.9215e-040.3080image
chr7:17344636-17345270:+THCAGefitinibEER3.8697e-05-0.1828image
ENSG00000106546.11,AHRTHCAGefitinibEAG3.8697e-05-0.1828image
ENSG00000106546.11,AHRTHYMABT.888EAG5.1311e-03-0.2738image
chr7:17344636-17345270:+THYMABT.888EER5.1311e-03-0.2738image
chr7:17344636-17345270:+UCECKIN001.135EER1.1724e-030.2498image
ENSG00000106546.11,AHRUCECKIN001.135EAG1.1724e-030.2498image
ENSG00000106546.11,AHRUCSABT.263EAG2.6642e-030.4200image
chr7:17344636-17345270:+UCSABT.263EER2.5967e-030.4209image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType
chr7:17344636-17345270:+ENST00000242057.7P35869DB00338OmeprazoleSmallMoleculeDrug
chr7:17344636-17345270:+ENST00000242057.7P35869DB00379MexiletineSmallMoleculeDrug
chr7:17344636-17345270:+ENST00000242057.7P35869DB00393NimodipineSmallMoleculeDrug
chr7:17344636-17345270:+ENST00000242057.7P35869DB00499FlutamideSmallMoleculeDrug
chr7:17344636-17345270:+ENST00000242057.7P35869DB01076AtorvastatinSmallMoleculeDrug
chr7:17344636-17345270:+ENST00000242057.7P35869DB01097LeflunomideSmallMoleculeDrug
chr7:17344636-17345270:+ENST00000242057.7P35869DB06083TapinarofSmallMoleculeDrug
chr7:17344636-17345270:+ENST00000242057.7P35869DB08995DiosminSmallMoleculeDrug
chr7:17344636-17345270:+ENST00000242057.7P35869DB12328CantharidinSmallMoleculeDrug
chr7:17344636-17345270:+ENST00000463496.1P35869DB00338OmeprazoleSmallMoleculeDrug
chr7:17344636-17345270:+ENST00000463496.1P35869DB00379MexiletineSmallMoleculeDrug
chr7:17344636-17345270:+ENST00000463496.1P35869DB00393NimodipineSmallMoleculeDrug
chr7:17344636-17345270:+ENST00000463496.1P35869DB00499FlutamideSmallMoleculeDrug
chr7:17344636-17345270:+ENST00000463496.1P35869DB01076AtorvastatinSmallMoleculeDrug
chr7:17344636-17345270:+ENST00000463496.1P35869DB01097LeflunomideSmallMoleculeDrug
chr7:17344636-17345270:+ENST00000463496.1P35869DB06083TapinarofSmallMoleculeDrug
chr7:17344636-17345270:+ENST00000463496.1P35869DB08995DiosminSmallMoleculeDrug
chr7:17344636-17345270:+ENST00000463496.1P35869DB12328CantharidinSmallMoleculeDrug