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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: PGAM5 (ImmuneEditome ID:192111)

1. Gene summary of enriched editing regions for PGAM5

check button Gene summary
Gene informationGene symbol

PGAM5

Gene ID

192111

GeneSynonymsBXLBV68
GeneCytomap

12q24.33

GeneTypeprotein-coding
GeneDescriptionserine/threonine-protein phosphatase PGAM5, mitochondrial|Bcl-XL-binding protein v68|PGAM family member 5, serine/threonine protein phosphatase, mitochondrial|phosphoglycerate mutase family member 5
GeneModificationdate20230518
UniprotIDQ96HS1;F5GXG4
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr12:132721279-132722380:+ENST00000498926.5ENSG00000247077.5PGAM5UTR3AluJo,AluSg,AluSqchr12:132721279-132722380:+.alignment
chr12:132721279-132722380:+ENST00000543955.4ENSG00000247077.5PGAM5UTR3AluJo,AluSg,AluSqchr12:132721279-132722380:+.alignment


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2. Tumor-specific enriched editing regions for PGAM5


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr12:132721279-132722380:+BRCAEER2.6129e-08image
ENSG00000247077.5,PGAM5BRCAEAG2.7216e-08image
chr12:132721279-132722380:+COADEER1.5905e-10image
ENSG00000247077.5,PGAM5COADEAG1.6653e-10image
chr12:132721279-132722380:+HNSCEER5.2350e-12image
ENSG00000247077.5,PGAM5HNSCEAG5.2350e-12image
chr12:132721279-132722380:+KIRCEER8.0468e-09image
ENSG00000247077.5,PGAM5KIRCEAG1.1146e-08image
chr12:132721279-132722380:+LIHCEER2.2097e-03image
ENSG00000247077.5,PGAM5LIHCEAG2.0995e-03image
chr12:132721279-132722380:+LUADEER2.8180e-02image
ENSG00000247077.5,PGAM5LUADEAG2.8180e-02image
chr12:132721279-132722380:+THCAEER1.0477e-09image
ENSG00000247077.5,PGAM5THCAEAG1.0477e-09image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr12:132721279-132722380:+BLCAPathEER8.2102e-031.9900e-020.1155image
ENSG00000247077.5,PGAM5BLCAPathEAG8.2102e-031.9900e-020.1155image
ENSG00000247077.5,PGAM5CESCCliEAG3.1700e-023.9252e-03-0.1663image
chr12:132721279-132722380:+CESCCliEER3.1700e-023.9252e-03-0.1663image
chr12:132721279-132722380:+HNSCCliEER8.3919e-031.2754e-030.1457image
ENSG00000247077.5,PGAM5HNSCCliEAG8.3919e-031.2754e-030.1457image
chr12:132721279-132722380:+READPathEER1.7879e-026.9002e-03-0.2155image
ENSG00000247077.5,PGAM5READPathEAG1.7879e-026.9002e-03-0.2155image
chr12:132721279-132722380:+THCAPathEER3.0418e-029.3597e-030.1159image
ENSG00000247077.5,PGAM5THCAPathEAG3.0418e-029.3597e-030.1159image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr12:132721279-132722380:+BRCAEER3.0607e-021.0748e-023.6412e-03image
ENSG00000247077.5,PGAM5BRCAEAG3.0607e-021.0748e-023.6412e-03image
chr12:132721279-132722380:+LIHCEER3.5654e-022.4333e-032.5096e-03image
ENSG00000247077.5,PGAM5LIHCEAG2.9792e-022.7864e-032.7679e-03image
chr12:132721279-132722380:+STADEER1.5311e-025.5498e-031.1966e+02image
ENSG00000247077.5,PGAM5STADEAG4.1929e-026.3535e-031.1360e+02image

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3. Enriched editing regions and immune related genes for PGAM5


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr12:132721279-132722380:+COADEERENSG00000173193,PARP140.44256.0884e-105.7144e-250.5696imageNNNAMacrophages_M1GSVA_HALLMARK_PEROXISOME
chr12:132721279-132722380:+COADEERENSG00000160710,ADAR0.42763.0489e-091.4158e-140.4426imageNNADARMacrophages_M1GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr12:132721279-132722380:+COADEERENSG00000138496,PARP90.42743.4391e-097.5714e-170.4753imageNNNAMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr12:132721279-132722380:+COADEERENSG00000152778,IFIT50.41301.1454e-082.2055e-170.4825imageNNIFIT5Macrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr12:132721279-132722380:+COADEERENSG00000114383,TUSC2-0.40792.4414e-085.7474e-13-0.4172imageNNNANeutrophilsGSVA_HALLMARK_DNA_REPAIR
chr12:132721279-132722380:+COADEERENSG00000132530,XAF10.40264.7228e-082.0483e-170.4829imageNNXAF1Macrophages_M1GSVA_HALLMARK_PEROXISOME
chr12:132721279-132722380:+COADEERENSG00000181381,DDX60L0.40065.8617e-081.5550e-130.4265imageNNDDX60LNeutrophilsGSVA_HALLMARK_DNA_REPAIR
chr12:132721279-132722380:+COADEERENSG00000177409,SAMD9L0.39637.4713e-084.3773e-120.4024imageNNNAMacrophages_M1GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr12:132721279-132722380:+COADEERENSG00000168101,NUDT16L1-0.39337.8780e-081.0290e-13-0.4293imageNNNANeutrophilsGSVA_HALLMARK_DNA_REPAIR
chr12:132721279-132722380:+COADEERENSG00000147459,DOCK50.37999.0068e-081.8126e-200.5210imageNNDOCK5EosinophilsGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr12:132721279-132722380:+COADEERENSG00000173193,PARP140.44256.0884e-105.7144e-250.5696imageNNNAMacrophages_M1GSVA_HALLMARK_PEROXISOME
chr12:132721279-132722380:+COADEERENSG00000160710,ADAR0.42763.0489e-091.4158e-140.4426imageNNADARMacrophages_M1GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr12:132721279-132722380:+COADEERENSG00000138496,PARP90.42743.4391e-097.5714e-170.4753imageNNNAMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr12:132721279-132722380:+COADEERENSG00000152778,IFIT50.41301.1454e-082.2055e-170.4825imageNNIFIT5Macrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr12:132721279-132722380:+COADEERENSG00000114383,TUSC2-0.40792.4414e-085.7474e-13-0.4172imageNNNANeutrophilsGSVA_HALLMARK_DNA_REPAIR
chr12:132721279-132722380:+COADEERENSG00000132530,XAF10.40264.7228e-082.0483e-170.4829imageNNXAF1Macrophages_M1GSVA_HALLMARK_PEROXISOME
chr12:132721279-132722380:+COADEERENSG00000181381,DDX60L0.40065.8617e-081.5550e-130.4265imageNNDDX60LNeutrophilsGSVA_HALLMARK_DNA_REPAIR
chr12:132721279-132722380:+COADEERENSG00000177409,SAMD9L0.39637.4713e-084.3773e-120.4024imageNNNAMacrophages_M1GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr12:132721279-132722380:+COADEERENSG00000168101,NUDT16L1-0.39337.8780e-081.0290e-13-0.4293imageNNNANeutrophilsGSVA_HALLMARK_DNA_REPAIR
chr12:132721279-132722380:+COADEERENSG00000147459,DOCK50.37999.0068e-081.8126e-200.5210imageNNDOCK5EosinophilsGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING

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4. Enriched editing regions and immune related splicing for PGAM5


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000247077.5,PGAM5
COADEAGIRENSG00000165724.5chr9137586966:137587823:137588658:1375887180.22233.3934e-021.3576e-130.4295imageNACIN1;AIFM1;AUH;BCCIP;BUD13;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000247077.5,PGAM5
COADEAGMEXENSG00000141971.8chr1917406144:17406296:17413096:17413305:17422331:17422458:17423497:174236170.38505.5241e-071.4462e-140.4477imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;ZNF184NAMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000247077.5,PGAM5
COADEAGIRENSG00000137145.16chr919369836:19369987:19371755:193718200.22713.4216e-029.0379e-180.4884imageNACIN1;ADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000247077.5,PGAM5
COADEAGIRENSG00000187742.10chr989338457:89338580:89339863:893399470.22613.4242e-022.8692e-130.4229imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr12:132721279-132722380:+
COADEERIRENSG00000120549.11chr1024494499:24494604:24495146:244951960.20313.8998e-023.1503e-130.4451imageNNNAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000247077.5,PGAM5
COADEAGIRENSG00000158941.12chr822612702:22613136:22614091:226143140.25081.1052e-023.1074e-140.4374imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000247077.5,PGAM5
COADEAGESENSG00000168827.10chr3158684630:158684668:158690162:158690323:158691138:158691192-0.22247.0506e-032.4679e-12-0.4073imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RC3H1;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NANK_cells_activatedGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr12:132721279-132722380:+
COADEERIRENSG00000103064.9chr1668287322:68287871:68290395:682904910.24281.2649e-021.0943e-120.4197imageNNNADendritic_cells_activatedGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000247077.5,PGAM5
COADEAGIRENSG00000083223.13chr986298766:86299272:86301275:863016010.24737.2014e-032.7354e-150.4739imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;MOV10;MSI2;NOP56;NOP58;NPM1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RC3H1;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NANeutrophilsGSVA_HALLMARK_DNA_REPAIR
chr12:132721279-132722380:+
COADEERIRENSG00000123636.13chr2159336941:159337077:159337461:1593377720.19941.2691e-025.0712e-100.4069imageNNNAEosinophilsGSVA_HALLMARK_P53_PATHWAY

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5. Enriched editing regions and immune infiltration for PGAM5


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr12:132721279-132722380:+ACCEERNK_cells_resting2.8656e-020.2495image
ENSG00000247077.5,PGAM5ACCEAGNK_cells_resting2.8656e-020.2495image
chr12:132721279-132722380:+BLCAEERMacrophages_M13.4581e-100.3054image
ENSG00000247077.5,PGAM5BLCAEAGMacrophages_M13.4581e-100.3054image
chr12:132721279-132722380:+BRCAEERT_cells_CD4_memory_resting2.6132e-040.1108image
ENSG00000247077.5,PGAM5BRCAEAGT_cells_CD4_memory_resting2.5077e-040.1112image
chr12:132721279-132722380:+CESCEERT_cells_CD83.2527e-060.2633image
ENSG00000247077.5,PGAM5CESCEAGT_cells_CD83.2527e-060.2633image
chr12:132721279-132722380:+CHOLEERMacrophages_M24.2100e-02-0.3455image
ENSG00000247077.5,PGAM5CHOLEAGMacrophages_M24.2100e-02-0.3455image
chr12:132721279-132722380:+COADEERMacrophages_M12.4507e-030.1823image
ENSG00000247077.5,PGAM5COADEAGMacrophages_M12.4507e-030.1823image
ENSG00000247077.5,PGAM5DLBCEAGDendritic_cells_activated9.0944e-030.3727image
chr12:132721279-132722380:+ESCAEERT_cells_CD4_memory_activated1.5087e-020.1912image
ENSG00000247077.5,PGAM5ESCAEAGT_cells_CD4_memory_activated1.5087e-020.1912image
chr12:132721279-132722380:+GBMEERMacrophages_M03.4173e-08-0.4111image
ENSG00000247077.5,PGAM5GBMEAGMacrophages_M03.4173e-08-0.4111image
chr12:132721279-132722380:+HNSCEERMacrophages_M11.2912e-110.2969image
ENSG00000247077.5,PGAM5HNSCEAGMacrophages_M11.2912e-110.2969image
chr12:132721279-132722380:+KIRCEERT_cells_gamma_delta4.4801e-050.2070image
ENSG00000247077.5,PGAM5KIRCEAGT_cells_gamma_delta4.4801e-050.2070image
chr12:132721279-132722380:+KIRPEERNK_cells_resting4.9201e-020.1160image
ENSG00000247077.5,PGAM5KIRPEAGNK_cells_resting4.9201e-020.1160image
chr12:132721279-132722380:+LAMLEERMacrophages_M25.6051e-03-0.2321image
ENSG00000247077.5,PGAM5LAMLEAGMacrophages_M25.6051e-03-0.2321image
chr12:132721279-132722380:+LGGEERT_cells_CD4_memory_resting6.3074e-03-0.1186image
ENSG00000247077.5,PGAM5LGGEAGT_cells_CD4_memory_resting6.3074e-03-0.1186image
chr12:132721279-132722380:+LIHCEERMacrophages_M02.0473e-07-0.2650image
ENSG00000247077.5,PGAM5LIHCEAGMacrophages_M02.0554e-07-0.2650image
chr12:132721279-132722380:+LUADEERT_cells_CD89.4695e-050.1722image
ENSG00000247077.5,PGAM5LUADEAGT_cells_CD89.4682e-050.1722image
chr12:132721279-132722380:+LUSCEERT_cells_CD85.5533e-090.2575image
ENSG00000247077.5,PGAM5LUSCEAGT_cells_CD85.5533e-090.2575image
chr12:132721279-132722380:+MESOEERNeutrophils1.7432e-03-0.3406image
ENSG00000247077.5,PGAM5MESOEAGNeutrophils1.7432e-03-0.3406image
chr12:132721279-132722380:+OVEERT_cells_CD88.2331e-030.1544image
ENSG00000247077.5,PGAM5OVEAGT_cells_CD81.1502e-020.1477image
chr12:132721279-132722380:+PAADEERNK_cells_resting2.4455e-030.2258image
ENSG00000247077.5,PGAM5PAADEAGNK_cells_resting2.4455e-030.2258image
chr12:132721279-132722380:+PCPGEERPlasma_cells2.9789e-030.2208image
ENSG00000247077.5,PGAM5PCPGEAGPlasma_cells2.9789e-030.2208image
chr12:132721279-132722380:+PRADEERMacrophages_M11.9801e-030.1382image
ENSG00000247077.5,PGAM5PRADEAGMacrophages_M11.6720e-030.1404image
chr12:132721279-132722380:+READEERT_cells_CD4_naive7.6808e-030.2719image
ENSG00000247077.5,PGAM5READEAGT_cells_CD4_naive7.6808e-030.2719image
chr12:132721279-132722380:+SARCEERT_cells_gamma_delta1.6735e-040.2327image
ENSG00000247077.5,PGAM5SARCEAGT_cells_gamma_delta1.6921e-040.2325image
chr12:132721279-132722380:+SKCMEERT_cells_CD86.0359e-110.2955image
ENSG00000247077.5,PGAM5SKCMEAGT_cells_CD86.0359e-110.2955image
chr12:132721279-132722380:+STADEERMacrophages_M13.0186e-040.1873image
ENSG00000247077.5,PGAM5STADEAGMacrophages_M12.9511e-040.1876image
chr12:132721279-132722380:+TGCTEERMacrophages_M26.7071e-08-0.4171image
ENSG00000247077.5,PGAM5TGCTEAGMacrophages_M26.7071e-08-0.4171image
chr12:132721279-132722380:+THCAEERT_cells_CD4_memory_activated1.2354e-040.1703image
ENSG00000247077.5,PGAM5THCAEAGT_cells_CD4_memory_activated1.2354e-040.1703image
chr12:132721279-132722380:+THYMEERT_cells_CD4_naive1.3455e-09-0.5220image
ENSG00000247077.5,PGAM5THYMEAGT_cells_CD4_naive1.3455e-09-0.5220image
chr12:132721279-132722380:+UCECEERDendritic_cells_activated4.1944e-020.1540image
ENSG00000247077.5,PGAM5UCECEAGDendritic_cells_activated4.1944e-020.1540image


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6. Enriched editing regions and immune gene sets for PGAM5


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr12:132721279-132722380:+BLCAEER8.4814e-050.19402.0370e-030.15293.5097e-050.20418.6870e-070.2416image
ENSG00000247077.5,PGAM5BLCAEAG8.4814e-050.19402.0370e-030.15293.5097e-050.20418.6870e-070.2416image
chr12:132721279-132722380:+LUADEER2.0528e-030.13637.2924e-040.14933.0350e-030.13116.6404e-030.1202image
ENSG00000247077.5,PGAM5LUADEAG2.0527e-030.13637.2924e-040.14933.0349e-030.13116.6407e-030.1202image
ENSG00000247077.5,PGAM5STADEAG4.4412e-030.14804.7844e-020.10321.3407e-020.12881.4257e-020.1277image
chr12:132721279-132722380:+TGCTEER1.1061e-02-0.20364.0196e-02-0.16506.9031e-05-0.31414.1594e-04-0.2801image
ENSG00000247077.5,PGAM5TGCTEAG1.1061e-02-0.20364.0196e-02-0.16506.9031e-05-0.31414.1594e-04-0.2801image
chr12:132721279-132722380:+THYMEER1.6760e-02-0.21987.5139e-05-0.35621.4029e-020.22561.6045e-050.3857image
ENSG00000247077.5,PGAM5THYMEAG1.6760e-02-0.21987.5139e-05-0.35621.4029e-020.22561.6045e-050.3857image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000247077.5,PGAM5ACCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG1.5779e-02-0.2743image
chr12:132721279-132722380:+ACCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.5779e-02-0.2743image
ENSG00000247077.5,PGAM5BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG3.8286e-170.4018image
chr12:132721279-132722380:+BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER3.8286e-170.4018image
chr12:132721279-132722380:+BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.5249e-170.2536image
ENSG00000247077.5,PGAM5BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.8278e-170.2532image
chr12:132721279-132722380:+CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.2011e-200.4972image
ENSG00000247077.5,PGAM5CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.2011e-200.4972image
chr12:132721279-132722380:+CHOLGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.2051e-02-0.4198image
ENSG00000247077.5,PGAM5CHOLGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.2051e-02-0.4198image
chr12:132721279-132722380:+COADGSVA_HALLMARK_PEROXISOMEEER8.3825e-11-0.3793image
ENSG00000247077.5,PGAM5COADGSVA_HALLMARK_PEROXISOMEEAG8.3825e-11-0.3793image
ENSG00000247077.5,PGAM5DLBCGSVA_HALLMARK_HYPOXIAEAG1.6468e-020.3446image
chr12:132721279-132722380:+ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.1213e-050.3283image
ENSG00000247077.5,PGAM5ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.1213e-050.3283image
ENSG00000247077.5,PGAM5GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.8702e-080.4096image
chr12:132721279-132722380:+GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.8702e-080.4096image
ENSG00000247077.5,PGAM5HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.7902e-280.4661image
chr12:132721279-132722380:+HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.7902e-280.4661image
ENSG00000247077.5,PGAM5KICHGSVA_HALLMARK_DNA_REPAIREAG1.0004e-02-0.3173image
ENSG00000247077.5,PGAM5KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.6159e-030.1606image
chr12:132721279-132722380:+KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.6159e-030.1606image
ENSG00000247077.5,PGAM5KIRPGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG4.3461e-04-0.2060image
chr12:132721279-132722380:+KIRPGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER4.3461e-04-0.2060image
ENSG00000247077.5,PGAM5LAMLGSVA_HALLMARK_E2F_TARGETSEAG4.1412e-03-0.2401image
chr12:132721279-132722380:+LAMLGSVA_HALLMARK_E2F_TARGETSEER4.1412e-03-0.2401image
ENSG00000247077.5,PGAM5LGGGSVA_HALLMARK_MYC_TARGETS_V1EAG8.8761e-07-0.2118image
chr12:132721279-132722380:+LGGGSVA_HALLMARK_MYC_TARGETS_V1EER8.8761e-07-0.2118image
chr12:132721279-132722380:+LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEER4.8325e-130.3627image
ENSG00000247077.5,PGAM5LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG5.7742e-130.3616image
ENSG00000247077.5,PGAM5LUADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.4075e-090.2642image
chr12:132721279-132722380:+LUADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.4077e-090.2642image
chr12:132721279-132722380:+LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER9.4370e-240.4293image
ENSG00000247077.5,PGAM5LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG9.4370e-240.4293image
ENSG00000247077.5,PGAM5MESOGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG3.1541e-02-0.2377image
chr12:132721279-132722380:+MESOGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER3.1541e-02-0.2377image
ENSG00000247077.5,PGAM5OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.2581e-060.2609image
chr12:132721279-132722380:+OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.5090e-060.2647image
ENSG00000247077.5,PGAM5PAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.1023e-020.1901image
chr12:132721279-132722380:+PAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.1023e-020.1901image
chr12:132721279-132722380:+PCPGGSVA_HALLMARK_E2F_TARGETSEER1.9441e-04-0.2750image
ENSG00000247077.5,PGAM5PCPGGSVA_HALLMARK_E2F_TARGETSEAG1.9441e-04-0.2750image
chr12:132721279-132722380:+PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER9.1958e-060.1971image
ENSG00000247077.5,PGAM5PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.1156e-060.2009image
chr12:132721279-132722380:+READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.7924e-050.3940image
ENSG00000247077.5,PGAM5READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.7924e-050.3940image
ENSG00000247077.5,PGAM5SARCGSVA_HALLMARK_MYC_TARGETS_V2EAG6.4560e-04-0.2114image
chr12:132721279-132722380:+SARCGSVA_HALLMARK_MYC_TARGETS_V2EER4.4285e-04-0.2176image
ENSG00000247077.5,PGAM5SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.1510e-100.2872image
chr12:132721279-132722380:+SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.1510e-100.2872image
ENSG00000247077.5,PGAM5STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.8834e-120.3486image
chr12:132721279-132722380:+STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER9.4992e-120.3454image
ENSG00000247077.5,PGAM5TGCTGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.3828e-07-0.4079image
chr12:132721279-132722380:+TGCTGSVA_HALLMARK_TGF_BETA_SIGNALINGEER1.3828e-07-0.4079image
ENSG00000247077.5,PGAM5THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG5.6838e-090.2560image
chr12:132721279-132722380:+THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER5.6838e-090.2560image
chr12:132721279-132722380:+THYMGSVA_HALLMARK_G2M_CHECKPOINTEER1.3937e-08-0.4932image
ENSG00000247077.5,PGAM5THYMGSVA_HALLMARK_G2M_CHECKPOINTEAG1.3937e-08-0.4932image
ENSG00000247077.5,PGAM5UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.0534e-060.3500image
chr12:132721279-132722380:+UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.0534e-060.3500image
chr12:132721279-132722380:+UCSGSVA_HALLMARK_MYOGENESISEER1.0601e-03-0.4261image
ENSG00000247077.5,PGAM5UCSGSVA_HALLMARK_MYOGENESISEAG1.0601e-03-0.4261image
ENSG00000247077.5,PGAM5UVMGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG4.6585e-05-0.4389image


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7. Enriched editing regions and drugs for PGAM5


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000247077.5,PGAM5ACCBleomycinEAG2.0803e-030.3456image
chr12:132721279-132722380:+ACCBleomycinEER2.0803e-030.3456image
ENSG00000247077.5,PGAM5BLCAAxitinibEAG2.1343e-100.3088image
chr12:132721279-132722380:+BLCAAxitinibEER2.1343e-100.3088image
chr12:132721279-132722380:+BRCAJNK.Inhibitor.VIIIEER1.3197e-07-0.1597image
ENSG00000247077.5,PGAM5BRCAJNK.Inhibitor.VIIIEAG1.1534e-07-0.1604image
chr12:132721279-132722380:+CESCGDC.0449EER1.6528e-11-0.3737image
ENSG00000247077.5,PGAM5CESCGDC.0449EAG1.6528e-11-0.3737image
chr12:132721279-132722380:+CHOLBMS.708163EER1.0368e-020.4278image
ENSG00000247077.5,PGAM5CHOLBMS.708163EAG1.0368e-020.4278image
chr12:132721279-132722380:+COADGefitinibEER4.5816e-08-0.3228image
ENSG00000247077.5,PGAM5COADGefitinibEAG4.5816e-08-0.3228image
ENSG00000247077.5,PGAM5DLBCDoxorubicinEAG9.9194e-040.4604image
chr12:132721279-132722380:+ESCAEHT.1864EER8.4923e-030.2068image
ENSG00000247077.5,PGAM5ESCAEHT.1864EAG8.4923e-030.2068image
ENSG00000247077.5,PGAM5GBMBIBW2992EAG1.1125e-06-0.3665image
chr12:132721279-132722380:+GBMBIBW2992EER1.1125e-06-0.3665image
ENSG00000247077.5,PGAM5HNSCFH535EAG1.8134e-100.2804image
chr12:132721279-132722380:+HNSCFH535EER1.8134e-100.2804image
ENSG00000247077.5,PGAM5KICHLFM.A13EAG3.3041e-03-0.3591image
ENSG00000247077.5,PGAM5KIRCCisplatinEAG1.7973e-10-0.3184image
chr12:132721279-132722380:+KIRCCisplatinEER1.7973e-10-0.3184image
ENSG00000247077.5,PGAM5KIRPEpothilone.BEAG4.9240e-040.2041image
chr12:132721279-132722380:+KIRPEpothilone.BEER4.9240e-040.2041image
ENSG00000247077.5,PGAM5LGGCamptothecinEAG9.3690e-050.1690image
chr12:132721279-132722380:+LGGCamptothecinEER9.3690e-050.1690image
ENSG00000247077.5,PGAM5LIHCBleomycinEAG3.8326e-170.4208image
chr12:132721279-132722380:+LIHCBleomycinEER3.4674e-170.4214image
chr12:132721279-132722380:+LUADAxitinibEER2.0364e-040.1639image
ENSG00000247077.5,PGAM5LUADAxitinibEAG2.0363e-040.1639image
ENSG00000247077.5,PGAM5LUSCGemcitabineEAG6.0297e-10-0.2728image
chr12:132721279-132722380:+LUSCGemcitabineEER6.0297e-10-0.2728image
ENSG00000247077.5,PGAM5MESODoxorubicinEAG1.4873e-03-0.3453image
chr12:132721279-132722380:+MESODoxorubicinEER1.4873e-03-0.3453image
chr12:132721279-132722380:+OVCHIR.99021EER3.0722e-030.1727image
ENSG00000247077.5,PGAM5OVCHIR.99021EAG2.9346e-030.1735image
ENSG00000247077.5,PGAM5PAADDMOGEAG2.7472e-020.1681image
chr12:132721279-132722380:+PAADDMOGEER2.7472e-020.1681image
chr12:132721279-132722380:+PCPGBAY.61.3606EER2.1539e-030.2279image
ENSG00000247077.5,PGAM5PCPGBAY.61.3606EAG2.1539e-030.2279image
chr12:132721279-132722380:+PRADATRAEER6.6179e-06-0.2004image
ENSG00000247077.5,PGAM5PRADATRAEAG1.6684e-05-0.1916image
chr12:132721279-132722380:+READJNK.9LEER4.0827e-03-0.2920image
ENSG00000247077.5,PGAM5READJNK.9LEAG4.0827e-03-0.2920image
ENSG00000247077.5,PGAM5SARCCytarabineEAG1.0540e-030.2032image
chr12:132721279-132722380:+SARCAKT.inhibitor.VIIIEER7.7667e-04-0.2084image
ENSG00000247077.5,PGAM5SKCMCytarabineEAG8.0225e-060.2041image
chr12:132721279-132722380:+SKCMCytarabineEER8.0225e-060.2041image
chr12:132721279-132722380:+STADCI.1040EER1.0684e-04-0.2006image
ENSG00000247077.5,PGAM5STADCI.1040EAG1.3392e-04-0.1978image
ENSG00000247077.5,PGAM5TGCTDocetaxelEAG2.2815e-050.3331image
chr12:132721279-132722380:+TGCTDocetaxelEER2.2815e-050.3331image
ENSG00000247077.5,PGAM5THCACI.1040EAG1.7574e-12-0.3076image
chr12:132721279-132722380:+THCACI.1040EER1.7574e-12-0.3076image
chr12:132721279-132722380:+THYMDoxorubicinEER1.8704e-110.5685image
ENSG00000247077.5,PGAM5THYMDoxorubicinEAG1.8704e-110.5685image
ENSG00000247077.5,PGAM5UCECABT.888EAG6.8478e-06-0.3327image
chr12:132721279-132722380:+UCECABT.888EER6.8478e-06-0.3327image
chr12:132721279-132722380:+UCSCisplatinEER7.9906e-05-0.5023image
ENSG00000247077.5,PGAM5UCSCisplatinEAG7.9906e-05-0.5023image
ENSG00000247077.5,PGAM5UVMEmbelinEAG1.0413e-020.2849image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType