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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: DNM1 (ImmuneEditome ID:1759)

1. Gene summary of enriched editing regions for DNM1

check button Gene summary
Gene informationGene symbol

DNM1

Gene ID

1759

GeneSynonymsDEE31|DEE31A|DEE31B|DNM|EIEE31
GeneCytomap

9q34.11

GeneTypeprotein-coding
GeneDescriptiondynamin-1
GeneModificationdate20230517
UniprotIDQ05193;A0A0D9SFE4;A0A0D9SFB1;A0A1B0GUX5;A0A0U1RQP1
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr9:128227065-128231524:+ENST00000441149.5ENSG00000106976.17DNM1ncRNA_intronicAluJb,AluJr4,AluJr,AluSg7,AluSx,AluSq2,L1ME4c,AluSz,AluSx4,L1ME3Cz,(TTTA)n,AluSq,AluSp,AluSx1chr9:128227065-128231524:+.alignment


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2. Tumor-specific enriched editing regions for DNM1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for DNM1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for DNM1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for DNM1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr9:128227065-128231524:+BRCAEERMonocytes1.5079e-020.2936image
ENSG00000106976.17,DNM1BRCAEAGMonocytes3.4605e-020.2494image
chr9:128227065-128231524:+ESCAEERNeutrophils1.4206e-020.2522image
ENSG00000106976.17,DNM1ESCAEAGNeutrophils1.4630e-020.2511image
ENSG00000106976.17,DNM1GBMEAGB_cells_naive2.8534e-02-0.2582image
chr9:128227065-128231524:+KIRCEERDendritic_cells_activated3.8681e-020.2460image
ENSG00000106976.17,DNM1KIRCEAGDendritic_cells_activated3.8355e-020.2464image
chr9:128227065-128231524:+KIRPEERMacrophages_M03.7770e-030.2230image
ENSG00000106976.17,DNM1KIRPEAGMacrophages_M03.5883e-030.2242image
chr9:128227065-128231524:+LGGEERMast_cells_activated1.1493e-020.2079image
ENSG00000106976.17,DNM1LGGEAGT_cells_CD4_naive1.3111e-020.2002image
ENSG00000106976.17,DNM1LUADEAGEosinophils9.6022e-030.5639image
chr9:128227065-128231524:+LUSCEERNK_cells_resting3.0395e-020.3664image
ENSG00000106976.17,DNM1LUSCEAGNK_cells_resting3.0823e-020.3604image
chr9:128227065-128231524:+SARCEERPlasma_cells2.1611e-020.3038image
ENSG00000106976.17,DNM1SARCEAGPlasma_cells1.5420e-020.3167image
chr9:128227065-128231524:+SKCMEERT_cells_regulatory_(Tregs)2.7543e-020.4023image
ENSG00000106976.17,DNM1SKCMEAGT_cells_regulatory_(Tregs)2.7543e-020.4023image
chr9:128227065-128231524:+STADEERMonocytes3.5573e-030.2465image
ENSG00000106976.17,DNM1STADEAGMonocytes1.9988e-030.2609image
chr9:128227065-128231524:+TGCTEERT_cells_regulatory_(Tregs)2.0679e-020.5011image
ENSG00000106976.17,DNM1TGCTEAGMonocytes1.9800e-020.4928image


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6. Enriched editing regions and immune gene sets for DNM1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr9:128227065-128231524:+BRCAGSVA_HALLMARK_FATTY_ACID_METABOLISMEER3.7177e-040.4193image
ENSG00000106976.17,DNM1BRCAGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG3.8801e-050.4649image
ENSG00000106976.17,DNM1ESCAGSVA_HALLMARK_ADIPOGENESISEAG2.6921e-030.3061image
chr9:128227065-128231524:+ESCAGSVA_HALLMARK_ADIPOGENESISEER3.7797e-030.2959image
chr9:128227065-128231524:+GBMGSVA_HALLMARK_HEME_METABOLISMEER4.9106e-030.3280image
ENSG00000106976.17,DNM1GBMGSVA_HALLMARK_HEME_METABOLISMEAG8.7614e-030.3068image
chr9:128227065-128231524:+KIRCGSVA_HALLMARK_KRAS_SIGNALING_DNEER4.4568e-040.4058image
ENSG00000106976.17,DNM1KIRCGSVA_HALLMARK_KRAS_SIGNALING_DNEAG4.6199e-040.4048image
ENSG00000106976.17,DNM1KIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.2158e-080.4162image
chr9:128227065-128231524:+KIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.7982e-080.4186image
chr9:128227065-128231524:+LAMLGSVA_HALLMARK_G2M_CHECKPOINTEER3.5892e-020.2266image
ENSG00000106976.17,DNM1LAMLGSVA_HALLMARK_G2M_CHECKPOINTEAG3.6558e-020.2258image
chr9:128227065-128231524:+LGGGSVA_HALLMARK_G2M_CHECKPOINTEER3.6616e-02-0.1726image
ENSG00000106976.17,DNM1LUADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG2.8684e-02-0.4890image
chr9:128227065-128231524:+OVGSVA_HALLMARK_UV_RESPONSE_UPEER1.0447e-040.3569image
ENSG00000106976.17,DNM1OVGSVA_HALLMARK_UV_RESPONSE_UPEAG1.0383e-040.3570image
ENSG00000106976.17,DNM1SARCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG3.3609e-020.2795image
chr9:128227065-128231524:+SARCGSVA_HALLMARK_PANCREAS_BETA_CELLSEER3.5208e-020.2796image
ENSG00000106976.17,DNM1SKCMGSVA_HALLMARK_APICAL_JUNCTIONEAG3.5066e-040.6094image
chr9:128227065-128231524:+SKCMGSVA_HALLMARK_APICAL_JUNCTIONEER3.5066e-040.6094image
ENSG00000106976.17,DNM1STADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG3.3129e-020.1815image
chr9:128227065-128231524:+STADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER3.1415e-020.1833image
ENSG00000106976.17,DNM1TGCTGSVA_HALLMARK_DNA_REPAIREAG3.2532e-020.4569image


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7. Enriched editing regions and drugs for DNM1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr9:128227065-128231524:+BRCAElesclomolEER1.5766e-03-0.3760image
ENSG00000106976.17,DNM1BRCAElesclomolEAG2.1230e-03-0.3564image
chr9:128227065-128231524:+CESCDasatinibEER2.3466e-04-0.4727image
ENSG00000106976.17,DNM1CESCDasatinibEAG2.3473e-04-0.4727image
ENSG00000106976.17,DNM1ESCABexaroteneEAG3.6137e-02-0.2165image
chr9:128227065-128231524:+ESCABexaroteneEER2.9955e-02-0.2240image
chr9:128227065-128231524:+GBMCEP.701EER6.2939e-050.4536image
ENSG00000106976.17,DNM1GBMCEP.701EAG1.5997e-040.4306image
chr9:128227065-128231524:+KIRCBexaroteneEER2.2450e-04-0.4245image
ENSG00000106976.17,DNM1KIRCBexaroteneEAG2.4413e-04-0.4223image
ENSG00000106976.17,DNM1KIRPMG.132EAG8.8231e-05-0.2996image
chr9:128227065-128231524:+KIRPMG.132EER6.1603e-05-0.3058image
chr9:128227065-128231524:+LAMLAICAREER2.1152e-02-0.2483image
ENSG00000106976.17,DNM1LAMLAICAREAG2.0952e-02-0.2487image
chr9:128227065-128231524:+LGGCMKEER4.0999e-020.1688image
ENSG00000106976.17,DNM1LUADCisplatinEAG9.3424e-03-0.5656image
chr9:128227065-128231524:+LUSCMG.132EER2.4162e-02-0.3860image
chr9:128227065-128231524:+OVCCT007093EER1.8821e-030.2893image
ENSG00000106976.17,DNM1OVCCT007093EAG1.8253e-030.2901image
ENSG00000106976.17,DNM1PAADKU.55933EAG4.7111e-020.4008image
ENSG00000106976.17,DNM1SARCBIRB.0796EAG1.8691e-02-0.3079image
chr9:128227065-128231524:+SARCMetforminEER1.5672e-02-0.3187image
ENSG00000106976.17,DNM1SKCMGefitinibEAG5.1790e-03-0.4973image
chr9:128227065-128231524:+SKCMGefitinibEER5.1790e-03-0.4973image
chr9:128227065-128231524:+TGCTCisplatinEER1.0250e-02-0.5472image
ENSG00000106976.17,DNM1TGCTCisplatinEAG3.9865e-03-0.5882image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType