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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: FUT11 (ImmuneEditome ID:170384)

1. Gene summary of enriched editing regions for FUT11

check button Gene summary
Gene informationGene symbol

FUT11

Gene ID

170384

GeneSynonymsFUCTXI
GeneCytomap

10q22.2

GeneTypeprotein-coding
GeneDescriptionalpha-(1,3)-fucosyltransferase 11|alpha (1,3) fucosyltransferase|fuc-TXI|fucT-XI|fucosyltransferase XI|galactoside 3-L-fucosyltransferase 11
GeneModificationdate20230329
UniprotIDQ495W5
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr10:73776234-73779600:+ENST00000489264.2ENSG00000196968.9FUT11ncRNA_exonicAluJb,(ATTT)n,AluJr,(T)n,AluSc,AluSz6,AluSx,AluJo,AluSq,AluSp,(TATCTA)nchr10:73776234-73779600:+.alignment


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2. Tumor-specific enriched editing regions for FUT11


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr10:73776234-73779600:+KICHEER6.1008e-03image
ENSG00000196968.9,FUT11KICHEAG6.1008e-03image
chr10:73776234-73779600:+KIRCEER1.5496e-06image
ENSG00000196968.9,FUT11KIRCEAG1.5496e-06image
chr10:73776234-73779600:+LUADEER1.5377e-04image
ENSG00000196968.9,FUT11LUADEAG1.5377e-04image
chr10:73776234-73779600:+LUSCEER1.3083e-07image
ENSG00000196968.9,FUT11LUSCEAG1.3083e-07image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for FUT11


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr10:73776234-73779600:+KICHEERENSG00000213977,TAX1BP3-0.59961.7536e-022.4313e-04-0.4466imageNNTAX1BP3T_cells_CD4_memory_activatedGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALING
chr10:73776234-73779600:+KICHEERENSG00000185201,IFITM2-0.55642.9803e-022.9560e-04-0.4412imageNNIFITM2T_cells_CD4_memory_activatedGSVA_HALLMARK_FATTY_ACID_METABOLISM
chr10:73776234-73779600:+KICHEERENSG00000126458,RRAS-0.54733.4210e-022.1494e-04-0.4500imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_FATTY_ACID_METABOLISM
chr10:73776234-73779600:+KICHEERENSG00000135723,FHOD1-0.52664.2150e-028.7184e-04-0.4091imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr10:73776234-73779600:+KICHEERENSG00000110171,TRIM3-0.52354.2783e-024.2249e-04-0.4309imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr10:73776234-73779600:+OVEERENSG00000214253,FIS10.29626.6986e-055.9940e-150.4369imageNNFIS1B_cells_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
chr10:73776234-73779600:+OVEERENSG00000249617,RP11-366M4.170.24681.4442e-039.0224e-130.4033imageNNNANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr10:73776234-73779600:+OVEERENSG00000239528,RPS14P80.23353.0453e-033.1261e-130.4108imageNNNAB_cells_memoryGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr10:73776234-73779600:+OVEERENSG00000124614,RPS100.23003.3416e-036.8493e-140.4211imageNNNANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr10:73776234-73779600:+OVEERENSG00000235354,CTA-276O3.40.22754.3095e-031.0838e-150.4476imageNNNAT_cells_CD8GSVA_HALLMARK_MITOTIC_SPINDLE

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4. Enriched editing regions and immune related splicing for FUT11


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr10:73776234-73779600:+
COADEERA3ENSG00000084207.11chr1167585137:67585241:67586106:67586123:67586078:67586123-0.07752.8538e-021.2033e-11-0.4303imageNNGSTP1Mast_cells_activatedGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
ENSG00000196968.9,FUT11
COADEAGA3ENSG00000084207.11chr1167585137:67585241:67586106:67586123:67586078:67586123-0.07753.2444e-021.2033e-11-0.4303imageNAUH;CELF2;CPSF6;CSTF2T;DDX3X;DDX42;DGCR8;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM22;RBM5;RNF219;SAFB2;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184GSTP1Mast_cells_activatedGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
ENSG00000196968.9,FUT11
THYMEAGMEXENSG00000138381.5chr2189665421:189665451:189666040:189666153:189667168:189667596:189667763:1896679450.41804.5108e-032.0678e-070.4810imageNAUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NOP56;NOP58;PRPF8;PTBP1;PUM2;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;RBM5;RNF219;RTCB;SAFB2;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1;XRN2;YTHDF1;ZC3H7B;ZNF184NAPlasma_cellsGSVA_HALLMARK_DNA_REPAIR
chr10:73776234-73779600:+
THYMEERMEXENSG00000141252.15chr17601794:601896:623532:623674:631549:631628:653290:653410-0.37424.0957e-032.2803e-05-0.4283imageNNNAMacrophages_M2GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
ENSG00000196968.9,FUT11
THYMEAGMEXENSG00000083857.9chr4186595688:186595826:186596539:186596968:186597033:186597171:186597681:186597792-0.35896.5376e-033.6608e-05-0.4206imageNALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;NONO;NOP56;NOP58;NPM1;PRPF8;PTBP1;PUM2;RANGAP1;RBFOX2;RBM10;RBM47;RBM5;RC3H1;RNF219;RTCB;SAFB2;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184FAT1T_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
chr10:73776234-73779600:+
THYMEERMEXENSG00000138381.5chr2189665421:189665451:189666040:189666153:189667168:189667596:189667763:1896679450.41804.3758e-032.0678e-070.4810imageNNNAPlasma_cellsGSVA_HALLMARK_DNA_REPAIR
chr10:73776234-73779600:+
THYMEERMEXENSG00000083857.9chr4186595688:186595826:186596539:186596968:186597033:186597171:186597681:186597792-0.35896.2784e-033.6608e-05-0.4206imageNNFAT1T_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
chr10:73776234-73779600:+
THYMEERMEXENSG00000174718.7chr1231970188:31970356:31980877:31986007:31987244:31987322:31992377:319929410.36291.8128e-021.6998e-050.4064imageNNNAMast_cells_restingGSVA_HALLMARK_PEROXISOME
ENSG00000196968.9,FUT11
THYMEAGMEXENSG00000141252.15chr17601794:601896:623532:623674:631549:631628:653290:653410-0.37424.2072e-032.2803e-05-0.4283imageNALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;RNF219;SAFB2;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAMacrophages_M2GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
ENSG00000196968.9,FUT11
THYMEAGMEXENSG00000138381.5chr2189665421:189665451:189666040:189666153:189667438:189667596:189667763:1896679450.41874.3985e-032.0914e-070.4808imageNAUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NOP56;NOP58;PRPF8;PTBP1;PUM2;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;RBM5;RNF219;RTCB;SAFB2;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1;XRN2;YTHDF1;ZC3H7B;ZNF184NAPlasma_cellsGSVA_HALLMARK_DNA_REPAIR

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5. Enriched editing regions and immune infiltration for FUT11


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr10:73776234-73779600:+ACCEERT_cells_CD4_memory_resting3.7361e-050.4572image
ENSG00000196968.9,FUT11ACCEAGT_cells_CD4_memory_resting3.7361e-050.4572image
chr10:73776234-73779600:+BLCAEERNK_cells_activated2.2571e-03-0.1531image
ENSG00000196968.9,FUT11BLCAEAGNK_cells_activated2.2571e-03-0.1531image
chr10:73776234-73779600:+BRCAEERT_cells_CD4_memory_activated1.7008e-050.1305image
ENSG00000196968.9,FUT11BRCAEAGT_cells_CD4_memory_activated1.7008e-050.1305image
chr10:73776234-73779600:+CHOLEERT_cells_gamma_delta2.6325e-020.3807image
ENSG00000196968.9,FUT11CHOLEAGT_cells_gamma_delta2.6325e-020.3807image
chr10:73776234-73779600:+COADEERMonocytes2.9523e-050.2614image
ENSG00000196968.9,FUT11COADEAGMonocytes2.9523e-050.2614image
chr10:73776234-73779600:+DLBCEERMacrophages_M21.6227e-02-0.3526image
ENSG00000196968.9,FUT11DLBCEAGMacrophages_M21.6227e-02-0.3526image
chr10:73776234-73779600:+ESCAEERMast_cells_activated4.8809e-02-0.1555image
ENSG00000196968.9,FUT11ESCAEAGMast_cells_activated4.8809e-02-0.1555image
chr10:73776234-73779600:+GBMEERMacrophages_M06.3458e-03-0.2123image
ENSG00000196968.9,FUT11GBMEAGMacrophages_M06.3458e-03-0.2123image
chr10:73776234-73779600:+HNSCEERT_cells_regulatory_(Tregs)3.3008e-06-0.2071image
ENSG00000196968.9,FUT11HNSCEAGT_cells_regulatory_(Tregs)3.3008e-06-0.2071image
chr10:73776234-73779600:+KICHEERDendritic_cells_activated1.7649e-020.2981image
ENSG00000196968.9,FUT11KICHEAGDendritic_cells_activated1.7649e-020.2981image
chr10:73776234-73779600:+KIRCEERDendritic_cells_activated7.3829e-070.2495image
ENSG00000196968.9,FUT11KIRCEAGDendritic_cells_activated7.3829e-070.2495image
chr10:73776234-73779600:+KIRPEERMonocytes1.9123e-020.1392image
ENSG00000196968.9,FUT11KIRPEAGMonocytes1.9123e-020.1392image
chr10:73776234-73779600:+LAMLEERB_cells_memory2.9967e-020.2228image
ENSG00000196968.9,FUT11LAMLEAGB_cells_memory2.9967e-020.2228image
chr10:73776234-73779600:+LGGEERT_cells_CD84.9182e-020.0856image
ENSG00000196968.9,FUT11LGGEAGT_cells_CD84.9182e-020.0856image
chr10:73776234-73779600:+LIHCEERMacrophages_M14.8135e-030.1686image
ENSG00000196968.9,FUT11LIHCEAGMacrophages_M14.8135e-030.1686image
chr10:73776234-73779600:+LUADEERMacrophages_M03.9105e-03-0.1273image
ENSG00000196968.9,FUT11LUADEAGMacrophages_M03.9105e-03-0.1273image
chr10:73776234-73779600:+LUSCEERT_cells_CD4_naive3.5847e-02-0.0944image
ENSG00000196968.9,FUT11LUSCEAGT_cells_CD4_naive3.5847e-02-0.0944image
chr10:73776234-73779600:+OVEERB_cells_memory2.7028e-040.2124image
ENSG00000196968.9,FUT11OVEAGB_cells_memory2.7028e-040.2124image
chr10:73776234-73779600:+PAADEERT_cells_regulatory_(Tregs)1.8893e-02-0.1768image
ENSG00000196968.9,FUT11PAADEAGT_cells_regulatory_(Tregs)1.8893e-02-0.1768image
chr10:73776234-73779600:+PCPGEERPlasma_cells4.7516e-020.1475image
ENSG00000196968.9,FUT11PCPGEAGPlasma_cells4.7516e-020.1475image
chr10:73776234-73779600:+PRADEERMonocytes1.9570e-020.1056image
ENSG00000196968.9,FUT11PRADEAGMonocytes1.9570e-020.1056image
chr10:73776234-73779600:+READEERDendritic_cells_activated1.7250e-040.3859image
ENSG00000196968.9,FUT11READEAGDendritic_cells_activated1.7250e-040.3859image
chr10:73776234-73779600:+SARCEERMast_cells_resting2.6924e-060.2879image
ENSG00000196968.9,FUT11SARCEAGMast_cells_resting2.6924e-060.2879image
chr10:73776234-73779600:+SKCMEERT_cells_gamma_delta8.7205e-040.1539image
ENSG00000196968.9,FUT11SKCMEAGT_cells_gamma_delta8.7205e-040.1539image
chr10:73776234-73779600:+STADEERT_cells_gamma_delta5.6728e-040.1828image
ENSG00000196968.9,FUT11STADEAGT_cells_gamma_delta5.6728e-040.1828image
chr10:73776234-73779600:+TGCTEERB_cells_naive2.4300e-020.1897image
ENSG00000196968.9,FUT11TGCTEAGB_cells_naive2.4300e-020.1897image
chr10:73776234-73779600:+THCAEERB_cells_memory2.5928e-03-0.1340image
ENSG00000196968.9,FUT11THCAEAGB_cells_memory2.5928e-03-0.1340image
chr10:73776234-73779600:+UCECEERNeutrophils3.8612e-020.1597image
ENSG00000196968.9,FUT11UCECEAGNeutrophils3.8612e-020.1597image
chr10:73776234-73779600:+UCSEERNeutrophils1.7769e-030.4084image
ENSG00000196968.9,FUT11UCSEAGNeutrophils1.7769e-030.4084image
chr10:73776234-73779600:+UVMEERT_cells_follicular_helper7.2420e-03-0.3097image
ENSG00000196968.9,FUT11UVMEAGT_cells_follicular_helper7.2420e-03-0.3097image


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6. Enriched editing regions and immune gene sets for FUT11


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr10:73776234-73779600:+BLCAEER1.1306e-03image2.2725e-02-0.1145image
ENSG00000196968.9,FUT11BLCAEAG1.1306e-03image2.2725e-02-0.1145image
chr10:73776234-73779600:+LUSCEER3.8176e-02image1.7720e-07-0.2321image
ENSG00000196968.9,FUT11LUSCEAG3.8176e-02image1.7720e-07-0.2321image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr10:73776234-73779600:+ACCGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.3060e-02-0.2854image
ENSG00000196968.9,FUT11ACCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.3060e-02-0.2854image
ENSG00000196968.9,FUT11BLCAGSVA_HALLMARK_BILE_ACID_METABOLISMEAG2.9841e-030.1488image
chr10:73776234-73779600:+BLCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER2.9841e-030.1488image
ENSG00000196968.9,FUT11BRCAGSVA_HALLMARK_MYOGENESISEAG4.5140e-11-0.1986image
chr10:73776234-73779600:+BRCAGSVA_HALLMARK_MYOGENESISEER4.5140e-11-0.1986image
ENSG00000196968.9,FUT11CESCGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.0424e-030.1881image
chr10:73776234-73779600:+CESCGSVA_HALLMARK_MITOTIC_SPINDLEEER1.0424e-030.1881image
ENSG00000196968.9,FUT11CHOLGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG4.5448e-03-0.4748image
chr10:73776234-73779600:+CHOLGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER4.5448e-03-0.4748image
ENSG00000196968.9,FUT11COADGSVA_HALLMARK_MYOGENESISEAG1.3270e-03-0.2023image
chr10:73776234-73779600:+COADGSVA_HALLMARK_MYOGENESISEER1.3270e-03-0.2023image
chr10:73776234-73779600:+DLBCGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.0355e-03-0.4432image
ENSG00000196968.9,FUT11DLBCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.0355e-03-0.4432image
ENSG00000196968.9,FUT11ESCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.3163e-030.2385image
chr10:73776234-73779600:+ESCAGSVA_HALLMARK_MITOTIC_SPINDLEEER2.3163e-030.2385image
ENSG00000196968.9,FUT11GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.9135e-030.2406image
chr10:73776234-73779600:+GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.9135e-030.2406image
chr10:73776234-73779600:+HNSCGSVA_HALLMARK_PROTEIN_SECRETIONEER4.6114e-070.2241image
ENSG00000196968.9,FUT11HNSCGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.6114e-070.2241image
ENSG00000196968.9,FUT11KICHGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG6.0140e-040.4205image
chr10:73776234-73779600:+KICHGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER6.0140e-040.4205image
ENSG00000196968.9,FUT11KIRCGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.4002e-050.2197image
chr10:73776234-73779600:+KIRCGSVA_HALLMARK_PROTEIN_SECRETIONEER1.4002e-050.2197image
chr10:73776234-73779600:+KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEER1.8950e-050.2513image
ENSG00000196968.9,FUT11KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.8950e-050.2513image
chr10:73776234-73779600:+LAMLGSVA_HALLMARK_HEME_METABOLISMEER2.3079e-02-0.2330image
ENSG00000196968.9,FUT11LAMLGSVA_HALLMARK_HEME_METABOLISMEAG2.3079e-02-0.2330image
ENSG00000196968.9,FUT11LGGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG4.9188e-03-0.1222image
chr10:73776234-73779600:+LGGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER4.9188e-03-0.1222image
chr10:73776234-73779600:+LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEER2.4028e-030.1814image
ENSG00000196968.9,FUT11LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG2.4028e-030.1814image
chr10:73776234-73779600:+LUADGSVA_HALLMARK_PROTEIN_SECRETIONEER1.0696e-090.2653image
ENSG00000196968.9,FUT11LUADGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.0696e-090.2653image
ENSG00000196968.9,FUT11LUSCGSVA_HALLMARK_MYOGENESISEAG3.8089e-08-0.2440image
chr10:73776234-73779600:+LUSCGSVA_HALLMARK_MYOGENESISEER3.8089e-08-0.2440image
ENSG00000196968.9,FUT11MESOGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.1125e-02-0.2543image
chr10:73776234-73779600:+MESOGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.1125e-02-0.2543image
chr10:73776234-73779600:+OVGSVA_HALLMARK_TGF_BETA_SIGNALINGEER4.3975e-05-0.2375image
ENSG00000196968.9,FUT11OVGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG4.3975e-05-0.2375image
ENSG00000196968.9,FUT11PAADGSVA_HALLMARK_MYOGENESISEAG3.7163e-04-0.2654image
chr10:73776234-73779600:+PAADGSVA_HALLMARK_MYOGENESISEER3.7163e-04-0.2654image
ENSG00000196968.9,FUT11PCPGGSVA_HALLMARK_MYC_TARGETS_V2EAG3.1057e-04-0.2651image
chr10:73776234-73779600:+PCPGGSVA_HALLMARK_MYC_TARGETS_V2EER3.1057e-04-0.2651image
ENSG00000196968.9,FUT11PRADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG3.4822e-04-0.1612image
chr10:73776234-73779600:+PRADGSVA_HALLMARK_PANCREAS_BETA_CELLSEER3.4822e-04-0.1612image
ENSG00000196968.9,FUT11READGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG1.6724e-040.3866image
chr10:73776234-73779600:+READGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER1.6724e-040.3866image
chr10:73776234-73779600:+SARCGSVA_HALLMARK_P53_PATHWAYEER4.5270e-09-0.3555image
ENSG00000196968.9,FUT11SARCGSVA_HALLMARK_P53_PATHWAYEAG4.5270e-09-0.3555image
chr10:73776234-73779600:+SKCMGSVA_HALLMARK_TGF_BETA_SIGNALINGEER5.1153e-05-0.1867image
ENSG00000196968.9,FUT11SKCMGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG5.1153e-05-0.1867image
ENSG00000196968.9,FUT11STADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG3.1030e-060.2456image
chr10:73776234-73779600:+STADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER3.1030e-060.2456image
ENSG00000196968.9,FUT11TGCTGSVA_HALLMARK_E2F_TARGETSEAG4.1941e-040.2931image
chr10:73776234-73779600:+TGCTGSVA_HALLMARK_E2F_TARGETSEER4.1941e-040.2931image
ENSG00000196968.9,FUT11THCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.8706e-080.2443image
chr10:73776234-73779600:+THCAGSVA_HALLMARK_PROTEIN_SECRETIONEER2.8706e-080.2443image
ENSG00000196968.9,FUT11THYMGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG7.7037e-03-0.2587image
chr10:73776234-73779600:+THYMGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER7.7037e-03-0.2587image
chr10:73776234-73779600:+UCECGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.7478e-03-0.2225image
ENSG00000196968.9,FUT11UCECGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.7478e-03-0.2225image
chr10:73776234-73779600:+UCSGSVA_HALLMARK_PROTEIN_SECRETIONEER2.9880e-040.4656image
ENSG00000196968.9,FUT11UCSGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.9880e-040.4656image
chr10:73776234-73779600:+UVMGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER2.5360e-02-0.2599image
ENSG00000196968.9,FUT11UVMGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG2.5360e-02-0.2599image


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7. Enriched editing regions and drugs for FUT11


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr10:73776234-73779600:+ACCGW843682XEER2.5261e-040.4107image
ENSG00000196968.9,FUT11ACCGW843682XEAG2.5261e-040.4107image
ENSG00000196968.9,FUT11BLCACEP.701EAG1.1709e-050.2183image
chr10:73776234-73779600:+BLCACEP.701EER1.1709e-050.2183image
ENSG00000196968.9,FUT11BRCABryostatin.1EAG3.7719e-130.2187image
chr10:73776234-73779600:+BRCABryostatin.1EER3.7719e-130.2187image
ENSG00000196968.9,FUT11CESCBMS.536924EAG6.3824e-050.2287image
chr10:73776234-73779600:+CESCBMS.536924EER6.3824e-050.2287image
ENSG00000196968.9,FUT11CHOLAZD6244EAG1.8692e-030.5141image
chr10:73776234-73779600:+CHOLAZD6244EER1.8692e-030.5141image
ENSG00000196968.9,FUT11COADAZD8055EAG6.5316e-050.2502image
chr10:73776234-73779600:+COADAZD8055EER6.5316e-050.2502image
chr10:73776234-73779600:+DLBCAZD6482EER3.8527e-06-0.6281image
ENSG00000196968.9,FUT11DLBCAZD6482EAG3.8527e-06-0.6281image
ENSG00000196968.9,FUT11ESCAJNJ.26854165EAG2.6975e-050.3253image
chr10:73776234-73779600:+ESCAJNJ.26854165EER2.6975e-050.3253image
ENSG00000196968.9,FUT11GBMBMS.754807EAG4.6190e-040.2704image
chr10:73776234-73779600:+GBMBMS.754807EER4.6190e-040.2704image
chr10:73776234-73779600:+HNSCA.770041EER3.2216e-090.2621image
ENSG00000196968.9,FUT11HNSCA.770041EAG3.2216e-090.2621image
ENSG00000196968.9,FUT11KICHCGP.60474EAG4.9536e-040.4262image
chr10:73776234-73779600:+KICHCGP.60474EER4.9536e-040.4262image
ENSG00000196968.9,FUT11KIRCGW843682XEAG1.4203e-200.4503image
chr10:73776234-73779600:+KIRCGW843682XEER1.4203e-200.4503image
chr10:73776234-73779600:+KIRPAMG.706EER5.2325e-080.3166image
ENSG00000196968.9,FUT11KIRPAMG.706EAG5.2325e-080.3166image
chr10:73776234-73779600:+LAMLMG.132EER3.1108e-020.2214image
ENSG00000196968.9,FUT11LAMLMG.132EAG3.1108e-020.2214image
ENSG00000196968.9,FUT11LGGAZ628EAG6.6052e-050.1727image
chr10:73776234-73779600:+LGGAZ628EER6.6052e-050.1727image
chr10:73776234-73779600:+LIHCBMS.754807EER8.7747e-050.2339image
ENSG00000196968.9,FUT11LIHCBMS.754807EAG8.7747e-050.2339image
chr10:73776234-73779600:+LUADLFM.A13EER9.4161e-050.1717image
ENSG00000196968.9,FUT11LUADLFM.A13EAG9.4161e-050.1717image
ENSG00000196968.9,FUT11LUSCBIRB.0796EAG2.1397e-06-0.2112image
chr10:73776234-73779600:+LUSCBIRB.0796EER2.1397e-06-0.2112image
ENSG00000196968.9,FUT11MESOMetforminEAG7.4219e-060.4724image
chr10:73776234-73779600:+MESOMetforminEER7.4219e-060.4724image
chr10:73776234-73779600:+OVCGP.082996EER5.6575e-080.3122image
ENSG00000196968.9,FUT11OVCGP.082996EAG5.6575e-080.3122image
ENSG00000196968.9,FUT11PAADDocetaxelEAG1.2513e-040.2892image
chr10:73776234-73779600:+PAADDocetaxelEER1.2513e-040.2892image
ENSG00000196968.9,FUT11PCPGGDC.0449EAG1.3728e-040.2797image
chr10:73776234-73779600:+PCPGGDC.0449EER1.3728e-040.2797image
ENSG00000196968.9,FUT11PRADA.770041EAG9.9836e-050.1754image
chr10:73776234-73779600:+PRADA.770041EER9.9836e-050.1754image
ENSG00000196968.9,FUT11READGSK269962AEAG3.7633e-030.3024image
chr10:73776234-73779600:+READGSK269962AEER3.7633e-030.3024image
chr10:73776234-73779600:+SARCAUY922EER1.7615e-070.3188image
ENSG00000196968.9,FUT11SARCAUY922EAG1.7615e-070.3188image
chr10:73776234-73779600:+SKCMAZD.2281EER4.7640e-030.1310image
ENSG00000196968.9,FUT11SKCMAZD.2281EAG4.7640e-030.1310image
ENSG00000196968.9,FUT11STADCCT007093EAG1.3188e-050.2299image
chr10:73776234-73779600:+STADCCT007093EER1.3188e-050.2299image
ENSG00000196968.9,FUT11TGCTLFM.A13EAG1.6781e-020.2011image
chr10:73776234-73779600:+TGCTLFM.A13EER1.6781e-020.2011image
ENSG00000196968.9,FUT11THCABMS.536924EAG5.0530e-120.3023image
chr10:73776234-73779600:+THCABMS.536924EER5.0530e-120.3023image
ENSG00000196968.9,FUT11THYMDocetaxelEAG1.0584e-020.2485image
chr10:73776234-73779600:+THYMDocetaxelEER1.0584e-020.2485image
chr10:73776234-73779600:+UCECABT.263EER2.4373e-04-0.2795image
ENSG00000196968.9,FUT11UCECABT.263EAG2.4373e-04-0.2795image
chr10:73776234-73779600:+UCSCyclopamineEER1.6053e-040.4834image
ENSG00000196968.9,FUT11UCSCyclopamineEAG1.6053e-040.4834image
chr10:73776234-73779600:+UVMABT.888EER2.2149e-030.3503image
ENSG00000196968.9,FUT11UVMABT.888EAG2.2149e-030.3503image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType