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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: DFFA (ImmuneEditome ID:1676)

1. Gene summary of enriched editing regions for DFFA

check button Gene summary
Gene informationGene symbol

DFFA

Gene ID

1676

GeneSynonymsDFF-45|DFF1|ICAD
GeneCytomap

1p36.22

GeneTypeprotein-coding
GeneDescriptionDNA fragmentation factor subunit alpha|DFF45|DNA fragmentation factor 45 kDa subunit|DNA fragmentation factor, 45kDa, alpha polypeptide|inhibitor of CAD
GeneModificationdate20230518
UniprotIDO00273;A0A024R4H5;K7ERT1
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr1:10457170-10458044:-ENST00000377038.6ENSG00000160049.10DFFAUTR3AluJr4,AluJr,AluSx1,MER20Bchr1:10457170-10458044:-.alignment
chr1:10459768-10462408:-ENST00000377038.6ENSG00000160049.10DFFAexonicAluY,AluSx1,AluSc8,AluSq2,AluJr,AluSxchr1:10459768-10462408:-.alignment


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2. Tumor-specific enriched editing regions for DFFA


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr1:10457170-10458044:-BRCAEER1.1425e-18image
chr1:10459768-10462408:-BRCAEER8.5425e-04image
ENSG00000160049.10,DFFABRCAEAG2.8946e-18image
chr1:10457170-10458044:-COADEER1.1374e-04image
chr1:10459768-10462408:-COADEER4.6888e-02image
ENSG00000160049.10,DFFACOADEAG1.8216e-04image
chr1:10457170-10458044:-HNSCEER5.8553e-13image
ENSG00000160049.10,DFFAHNSCEAG6.0955e-09image
chr1:10457170-10458044:-KICHEER7.7086e-04image
ENSG00000160049.10,DFFAKICHEAG3.7324e-03image
chr1:10457170-10458044:-KIRCEER1.6786e-20image
chr1:10459768-10462408:-KIRCEER5.8609e-10image
ENSG00000160049.10,DFFAKIRCEAG6.9358e-26image
chr1:10459768-10462408:-KIRPEER1.2018e-02image
ENSG00000160049.10,DFFAKIRPEAG5.9426e-03image
chr1:10457170-10458044:-LIHCEER7.4392e-04image
ENSG00000160049.10,DFFALIHCEAG9.9959e-04image
chr1:10457170-10458044:-LUADEER2.9498e-02image
ENSG00000160049.10,DFFALUADEAG4.5109e-02image
chr1:10457170-10458044:-LUSCEER4.3175e-03image
ENSG00000160049.10,DFFALUSCEAG2.4273e-02image
chr1:10457170-10458044:-PRADEER5.5907e-03image
chr1:10459768-10462408:-PRADEER3.9437e-03image
ENSG00000160049.10,DFFAPRADEAG5.0150e-04image
chr1:10457170-10458044:-STADEER4.7912e-02image
ENSG00000160049.10,DFFASTADEAG4.6600e-02image
chr1:10457170-10458044:-THCAEER2.1596e-08image
ENSG00000160049.10,DFFATHCAEAG2.4772e-07image
chr1:10457170-10458044:-UCECEER5.4397e-03image
chr1:10459768-10462408:-UCECEER4.2881e-02image
ENSG00000160049.10,DFFAUCECEAG8.4908e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr1:10457170-10458044:-BRCAPathEER4.6035e-023.6217e-020.0639image
ENSG00000160049.10,DFFAKICHPathEAG3.7385e-022.4944e-02-0.2802image
chr1:10457170-10458044:-KICHPathEER1.1934e-022.7077e-02-0.2763image
ENSG00000160049.10,DFFAKIRCPathEAG8.0997e-039.2121e-040.1442image
chr1:10459768-10462408:-KIRCPathEER1.5445e-024.6856e-030.1381image
chr1:10457170-10458044:-KIRCPathEER5.2123e-042.1451e-040.1615image
chr1:10459768-10462408:-TGCTCliEER6.6262e-031.5276e-03-0.3744image
ENSG00000160049.10,DFFATHCAPathEAG4.5966e-039.5409e-030.1158image
chr1:10457170-10458044:-THCAPathEER4.7412e-031.8158e-020.1058image
ENSG00000160049.10,DFFAUCSCliEAG1.3100e-023.7061e-03-0.3850image
chr1:10457170-10458044:-UCSCliEER4.7358e-027.2570e-03-0.3614image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for DFFA


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr1:10457170-10458044:-LIHCEERENSG00000116586,LAMTOR20.37391.4484e-093.2285e-200.4690imageNIGF2BP2;NOP58NANK_cells_activatedGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr1:10457170-10458044:-LIHCEERENSG00000148803,FUOM0.26581.3587e-053.7169e-150.4070imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr1:10457170-10458044:-LIHCEERENSG00000135441,BLOC1S10.23562.9656e-041.4822e-170.4380imageNIGF2BP2;NOP58BLOC1S1NK_cells_activatedGSVA_HALLMARK_UV_RESPONSE_DN
chr1:10457170-10458044:-LIHCEERENSG00000179085,DPM30.21828.9159e-044.5054e-260.5279imageNIGF2BP2;NOP58NAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr1:10457170-10458044:-LIHCEERENSG00000269313,MAGIX0.20771.5712e-031.4467e-160.4256imageNIGF2BP2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr1:10457170-10458044:-LIHCEERENSG00000128534,LSM8-0.18366.2748e-032.3791e-190.4592imageNIGF2BP2;NOP58NAMacrophages_M0GSVA_HALLMARK_BILE_ACID_METABOLISM
chr1:10457170-10458044:-LIHCEERENSG00000228300,C19orf240.17868.8669e-036.4417e-180.4424imageNIGF2BP2;NOP58NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr1:10457170-10458044:-LIHCEERENSG00000127540,UQCR110.16651.5940e-027.7271e-160.4161imageNIGF2BP2;NOP58NAMacrophages_M1GSVA_HALLMARK_UV_RESPONSE_DN
chr1:10457170-10458044:-LIHCEERENSG00000214253,FIS10.15122.8291e-022.5578e-250.5209imageNIGF2BP2;NOP58FIS1NK_cells_activatedGSVA_HALLMARK_UV_RESPONSE_DN
chr1:10457170-10458044:-LIHCEERENSG00000252147,RNY3P160.14593.3768e-023.0764e-160.4214imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr1:10459768-10462408:-KIRCEERENSG00000168701,TMEM2080.32411.1930e-063.4809e-200.4907imageNAUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;LARP7;LIN28B;MOV10;MSI2;NONO;NOP56;NOP58;PRPF8;PTBP1;RBM10;SF3A3;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TARDBP;TIA1;TNRC6A;TRA2A;U2AF1;U2AF2;UPF1;YWHAGNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr1:10459768-10462408:-KIRCEERENSG00000135404,CD630.31982.4609e-063.4944e-160.4410imageNACIN1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;LARP7;LIN28B;MOV10;MSI2;NONO;NOP56;NOP58;PRPF8;PTBP1;RBM10;RBM22;SF3A3;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TARDBP;TIA1;TNRC6A;TRA2A;U2AF1;U2AF2;UPF1;YWHAGCD63T_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
chr1:10459768-10462408:-KIRCEERENSG00000257727,CNPY20.30001.0256e-056.0293e-140.4092imageNACIN1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;LARP7;LIN28B;MOV10;MSI2;NONO;NOP56;NOP58;PRPF8;PTBP1;RBM10;RBM22;SF3A3;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TARBP2;TARDBP;TIA1;TNRC6A;TRA2A;U2AF1;U2AF2;UPF1;YWHAGNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr1:10459768-10462408:-KIRCEERENSG00000135441,BLOC1S10.30181.1000e-051.9750e-160.4443imageNACIN1;AUH;BUD13;CELF2;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;IGF2BP1;IGF2BP2;ILF3;KHDRBS1;KHDRBS2;LIN28B;MOV10;NOP56;NOP58;PRPF8;PTBP1;RBM10;SF3A3;SMNDC1;SND1;SRSF1;SRSF7;TARDBP;TNRC6A;TRA2A;U2AF1;U2AF2;UPF1BLOC1S1T_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr1:10459768-10462408:-KIRCEERENSG00000277791,PSMB30.29651.1238e-051.6198e-130.4027imageNACIN1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;LARP7;LIN28B;MOV10;MSI2;NONO;NOP56;NOP58;PRPF8;PTBP1;RBM10;RBM22;SF3A3;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TARBP2;TARDBP;TIA1;TNRC6A;TRA2A;U2AF1;U2AF2;UPF1;YWHAGNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr1:10459768-10462408:-KIRCEERENSG00000148834,GSTO10.29611.3915e-058.7054e-140.4068imageNACIN1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;LARP7;LIN28B;MOV10;MSI2;NONO;NOP56;NOP58;PRPF8;PTBP1;RBM10;RBM22;SF3A3;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TARDBP;TIA1;TNRC6A;TRA2A;U2AF1;U2AF2;UPF1;YWHAGNAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr1:10459768-10462408:-KIRCEERENSG00000140264,SERF20.29042.6626e-051.3060e-130.4042imageNACIN1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;LARP7;LIN28B;MOV10;MSI2;NONO;NOP56;NOP58;PRPF8;PTBP1;RBM10;RBM22;SF3A3;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TARDBP;TIA1;TNRC6A;TRA2A;U2AF1;U2AF2;UPF1;YWHAGNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
chr1:10459768-10462408:-KIRCEERENSG00000177556,ATOX10.28343.5558e-053.2247e-140.4133imageNACIN1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LARP7;LIN28B;MOV10;MSI2;NONO;NOP56;NOP58;PRPF8;PTBP1;RBM22;SF3A3;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF9;TARBP2;TIA1;TRA2A;U2AF1;U2AF2;UPF1;YWHAGNAT_cells_CD8GSVA_HALLMARK_UV_RESPONSE_DN
chr1:10459768-10462408:-KIRCEERENSG00000162910,MRPL550.28203.9222e-051.5100e-140.4181imageNAUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LIN28B;MOV10;NONO;NOP56;NOP58;PRPF8;PTBP1;RBM10;RBM22;SF3A3;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TARDBP;TIA1;TNRC6A;TRA2A;U2AF1;U2AF2;UPF1;YWHAGNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr1:10459768-10462408:-KIRCEERENSG00000175416,CLTB0.28364.1719e-052.1873e-170.4568imageNACIN1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;LARP7;LIN28B;MOV10;MSI2;NOP56;NOP58;PRPF8;PTBP1;QKI;RBM10;RBM22;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TARBP2;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1;YWHAGNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN

More results



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4. Enriched editing regions and immune related splicing for DFFA


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr1:10459768-10462408:-
COADEERIRENSG00000141258.8chr172379167:2379493:2380264:2380675-0.29981.7591e-031.9977e-25-0.6553imageNACIN1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LARP7;LIN28B;MOV10;MSI2;NONO;NOP56;NOP58;PRPF8;PTBP1;RBM10;RBM22;SF3A3;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TARBP2;TARDBP;TIA1;TNRC6A;TRA2A;U2AF1;U2AF2;UPF1NAEosinophilsGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr1:10459768-10462408:-
COADEERMEXENSG00000185043.6chr1590231356:90231507:90232218:90232427:90232978:90233703:90233834:902340470.26532.7413e-021.3952e-100.4289imageNAUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;LARP7;LIN28B;MOV10;MSI2;NONO;NOP56;NOP58;PRPF8;PTBP1;RBM10;RBM22;SF3A3;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TARDBP;TIA1;TNRC6A;TRA2A;U2AF1;U2AF2;UPF1;YWHAGCIB1Dendritic_cells_activatedGSVA_HALLMARK_P53_PATHWAY
chr1:10459768-10462408:-
COADEERIRENSG00000168488.14chr1628835932:28836490:28836727:28836919-0.24924.8249e-021.0805e-09-0.4095imageNACIN1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;LARP7;LIN28B;MOV10;MSI2;NONO;NOP56;NOP58;PRPF8;PTBP1;QKI;RBM10;RBM22;SF3A3;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TARBP2;TARDBP;TIA1;TNRC6A;TRA2A;U2AF1;U2AF2;UPF1;YWHAGNAMast_cells_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
ENSG00000160049.10,DFFA
DLBCEAGIRENSG00000101160.9chr2058996851:58997753:58997854:58997954-0.60764.3241e-026.7491e-05-0.6004imageNACIN1;ADAR;ALYREF;AUH;CAPRIN1;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28A;LIN28B;LSM11;METTL14;MOV10;MSI2;NOP58;NPM1;NUMA1;PTBP1;RANGAP1;RBFOX2;RBM22;RBM27;RBM47;RBM5;RTCB;SBDS;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1CTSZB_cells_naiveGSVA_HALLMARK_COAGULATION
chr1:10457170-10458044:-
HNSCEERMEXENSG00000150991.10chr12124911647:124911952:124912408:124912544:124913092:124913190:124913418:1249134400.24253.6088e-052.8080e-210.4118imageNIGF2BP2;NOP58NANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr1:10457170-10458044:-
HNSCEERMEXENSG00000150991.10chr12124911647:124911952:124912408:124912506:124913092:124913190:124913418:1249134280.23361.0476e-045.1438e-220.4188imageNIGF2BP2;NOP58NANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr1:10457170-10458044:-
HNSCEERMEXENSG00000150991.10chr12124911647:124911899:124912355:124912506:124913092:124913190:124913418:1249134280.22322.1442e-044.4563e-230.4285imageNIGF2BP2;NOP58NANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr1:10457170-10458044:-
HNSCEERESENSG00000092199.13chr1421234218:21234229:21263310:21263336:21269297:21269389-0.21595.1725e-041.8440e-20-0.4039imageNIGF2BP2;NOP58NAT_cells_CD4_memory_restingGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr1:10457170-10458044:-
HNSCEERIRENSG00000087269.11chr42939187:2941729:2942191:29423510.19582.8539e-031.6272e-230.4324imageNIGF2BP2;NOP58NAB_cells_naiveGSVA_HALLMARK_SPERMATOGENESIS
chr1:10457170-10458044:-
HNSCEERIRENSG00000117862.7chr152020130:52020405:52020925:52021012-0.18427.2653e-031.5014e-25-0.4500imageNIGF2BP2;NOP58NAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION

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5. Enriched editing regions and immune infiltration for DFFA


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr1:10457170-10458044:-ACCEERMacrophages_M22.5444e-020.2615image
chr1:10459768-10462408:-ACCEERB_cells_naive2.9684e-02-0.4268image
ENSG00000160049.10,DFFAACCEAGMacrophages_M22.4989e-020.2623image
chr1:10457170-10458044:-BLCAEERMacrophages_M11.7236e-090.2971image
chr1:10459768-10462408:-BLCAEERT_cells_CD84.3978e-020.1130image
ENSG00000160049.10,DFFABLCAEAGMacrophages_M17.5735e-100.3029image
chr1:10457170-10458044:-BRCAEERMacrophages_M12.5706e-040.1111image
chr1:10459768-10462408:-BRCAEERNK_cells_activated9.3158e-030.0837image
ENSG00000160049.10,DFFABRCAEAGNK_cells_activated1.1830e-040.1169image
chr1:10457170-10458044:-CESCEERT_cells_CD4_memory_resting1.1426e-03-0.1891image
chr1:10459768-10462408:-CESCEERDendritic_cells_resting4.4429e-030.1783image
ENSG00000160049.10,DFFACESCEAGDendritic_cells_activated8.0048e-040.1932image
chr1:10457170-10458044:-CHOLEERT_cells_CD4_naive8.3681e-030.4450image
chr1:10457170-10458044:-COADEERNeutrophils6.1861e-070.3006image
chr1:10459768-10462408:-COADEERDendritic_cells_activated1.0918e-020.1774image
ENSG00000160049.10,DFFACOADEAGNeutrophils6.2280e-060.2716image
chr1:10457170-10458044:-DLBCEERB_cells_naive2.8899e-03-0.4537image
ENSG00000160049.10,DFFADLBCEAGB_cells_naive2.8958e-03-0.4435image
chr1:10457170-10458044:-ESCAEERMacrophages_M25.4435e-030.2188image
ENSG00000160049.10,DFFAESCAEAGT_cells_regulatory_(Tregs)8.7982e-03-0.2065image
chr1:10457170-10458044:-GBMEERMonocytes8.8838e-050.2986image
chr1:10459768-10462408:-GBMEERT_cells_CD4_memory_resting2.9197e-020.1725image
ENSG00000160049.10,DFFAGBMEAGMonocytes1.0200e-040.2961image
chr1:10457170-10458044:-HNSCEERT_cells_CD4_memory_resting1.3818e-03-0.1448image
chr1:10459768-10462408:-HNSCEERB_cells_memory5.2534e-030.1384image
ENSG00000160049.10,DFFAHNSCEAGT_cells_CD84.6119e-040.1578image
chr1:10459768-10462408:-KICHEERB_cells_memory2.2066e-020.3264image
ENSG00000160049.10,DFFAKICHEAGT_cells_gamma_delta3.3063e-020.2668image
chr1:10457170-10458044:-KIRCEERT_cells_CD81.4114e-060.2448image
chr1:10459768-10462408:-KIRCEERT_cells_regulatory_(Tregs)1.0710e-030.1849image
ENSG00000160049.10,DFFAKIRCEAGT_cells_CD82.7610e-070.2599image
chr1:10457170-10458044:-KIRPEERT_cells_CD4_memory_resting1.2345e-03-0.1915image
ENSG00000160049.10,DFFAKIRPEAGT_cells_CD81.2908e-030.1907image
chr1:10457170-10458044:-LAMLEERMacrophages_M11.7572e-020.2080image
chr1:10459768-10462408:-LAMLEERMonocytes4.1389e-020.2377image
ENSG00000160049.10,DFFALAMLEAGMacrophages_M19.8747e-030.2182image
chr1:10457170-10458044:-LGGEERMacrophages_M11.4918e-050.1872image
chr1:10459768-10462408:-LGGEERPlasma_cells9.3434e-040.1468image
ENSG00000160049.10,DFFALGGEAGMacrophages_M12.5577e-050.1821image
chr1:10457170-10458044:-LIHCEERT_cells_CD81.1515e-020.1361image
chr1:10459768-10462408:-LIHCEERMast_cells_activated5.2361e-030.2284image
ENSG00000160049.10,DFFALIHCEAGT_cells_CD85.2110e-030.1501image
chr1:10457170-10458044:-LUADEERT_cells_CD4_memory_activated1.4274e-030.1414image
chr1:10459768-10462408:-LUADEERT_cells_gamma_delta5.0277e-030.1378image
ENSG00000160049.10,DFFALUADEAGT_cells_CD89.4741e-030.1143image
chr1:10457170-10458044:-LUSCEERT_cells_CD4_memory_activated1.5870e-100.2832image
chr1:10459768-10462408:-LUSCEERT_cells_CD4_naive1.1769e-020.1252image
ENSG00000160049.10,DFFALUSCEAGT_cells_CD4_memory_activated4.5785e-130.3179image
chr1:10457170-10458044:-MESOEERT_cells_gamma_delta2.3116e-030.3360image
chr1:10459768-10462408:-MESOEERMast_cells_resting3.5898e-02-0.3036image
ENSG00000160049.10,DFFAMESOEAGT_cells_CD82.6818e-030.3313image
chr1:10457170-10458044:-OVEERT_cells_CD85.5134e-050.2337image
chr1:10459768-10462408:-OVEERT_cells_follicular_helper3.7923e-030.1695image
ENSG00000160049.10,DFFAOVEAGMacrophages_M16.9512e-050.2306image
chr1:10457170-10458044:-PAADEERMast_cells_activated6.0247e-030.2080image
chr1:10459768-10462408:-PAADEERDendritic_cells_activated3.0527e-020.2123image
ENSG00000160049.10,DFFAPAADEAGMast_cells_activated1.7215e-020.1809image
chr1:10457170-10458044:-PCPGEERT_cells_CD4_memory_resting4.2455e-03-0.2151image
chr1:10459768-10462408:-PCPGEERPlasma_cells4.7734e-030.3016image
ENSG00000160049.10,DFFAPCPGEAGT_cells_CD4_memory_resting1.1032e-03-0.2446image
chr1:10457170-10458044:-PRADEERT_cells_regulatory_(Tregs)1.2226e-050.1946image
chr1:10459768-10462408:-PRADEERT_cells_CD4_memory_resting2.0447e-06-0.2405image
ENSG00000160049.10,DFFAPRADEAGT_cells_regulatory_(Tregs)3.5273e-070.2258image
chr1:10459768-10462408:-READEERT_cells_CD4_naive1.9576e-040.4048image
ENSG00000160049.10,DFFAREADEAGMonocytes9.3087e-030.2655image
chr1:10457170-10458044:-SARCEERMacrophages_M11.8222e-050.2659image
chr1:10459768-10462408:-SARCEERT_cells_CD4_memory_resting3.3735e-02-0.1452image
ENSG00000160049.10,DFFASARCEAGMacrophages_M14.4834e-060.2823image
chr1:10457170-10458044:-SKCMEERT_cells_CD84.4073e-070.2326image
ENSG00000160049.10,DFFASKCMEAGT_cells_CD82.0020e-070.2385image
chr1:10457170-10458044:-STADEERMacrophages_M11.3585e-030.1659image
chr1:10459768-10462408:-STADEERT_cells_CD84.6567e-030.1480image
ENSG00000160049.10,DFFASTADEAGT_cells_CD86.3094e-040.1764image
chr1:10457170-10458044:-TGCTEERMacrophages_M21.1904e-08-0.4394image
chr1:10459768-10462408:-TGCTEERDendritic_cells_resting4.3519e-030.2514image
ENSG00000160049.10,DFFATGCTEAGMacrophages_M23.5352e-06-0.3637image
chr1:10457170-10458044:-THCAEERPlasma_cells2.4846e-060.2090image
chr1:10459768-10462408:-THCAEERT_cells_regulatory_(Tregs)5.2719e-030.1326image
ENSG00000160049.10,DFFATHCAEAGT_cells_regulatory_(Tregs)4.9709e-070.2224image
chr1:10457170-10458044:-THYMEERT_cells_CD4_naive2.4698e-05-0.3856image
chr1:10459768-10462408:-THYMEERT_cells_CD4_memory_resting6.1068e-03-0.3098image
ENSG00000160049.10,DFFATHYMEAGT_cells_CD4_naive2.9729e-05-0.3805image
chr1:10459768-10462408:-UCECEERT_cells_regulatory_(Tregs)9.4307e-050.3395image
ENSG00000160049.10,DFFAUCECEAGPlasma_cells2.9673e-020.1654image
ENSG00000160049.10,DFFAUCSEAGT_cells_follicular_helper4.6863e-02-0.2692image


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6. Enriched editing regions and immune gene sets for DFFA


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr1:10459768-10462408:-LIHCEER2.1945e-02image4.7034e-030.2312image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000160049.10,DFFAPCPGEAG9.0923e-05-0.29151.7321e-03-0.23526.7534e-05-0.29654.8028e-02-0.1497image
ENSG00000160049.10,DFFASKCMEAG8.1052e-04-0.15504.2296e-07-0.23221.3032e-06-0.22244.7138e-020.0922image
ENSG00000160049.10,DFFATGCTEAG2.7123e-04-0.28951.5529e-02-0.19471.3189e-05-0.34326.5500e-04-0.2716image
chr1:10457170-10458044:-TGCTEER6.0313e-04-0.27343.7112e-02-0.16826.7302e-06-0.35393.5029e-04-0.2844image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr1:10459768-10462408:-ACCGSVA_HALLMARK_NOTCH_SIGNALINGEER1.5909e-02-0.4680image
ENSG00000160049.10,DFFAACCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.2247e-020.2509image
chr1:10457170-10458044:-ACCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.2475e-020.2911image
chr1:10457170-10458044:-BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER2.5807e-180.4200image
chr1:10459768-10462408:-BLCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER3.2224e-030.1647image
ENSG00000160049.10,DFFABLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.0667e-170.4125image
chr1:10457170-10458044:-BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.7200e-220.2887image
chr1:10459768-10462408:-BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER5.9321e-060.1453image
ENSG00000160049.10,DFFABRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.1649e-190.2692image
chr1:10459768-10462408:-CESCGSVA_HALLMARK_MITOTIC_SPINDLEEER1.6624e-03-0.1967image
chr1:10457170-10458044:-CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.0651e-120.3927image
ENSG00000160049.10,DFFACESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.3078e-100.3611image
ENSG00000160049.10,DFFACHOLGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG3.0718e-02-0.3711image
ENSG00000160049.10,DFFACOADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG5.9574e-04-0.2080image
chr1:10459768-10462408:-COADGSVA_HALLMARK_SPERMATOGENESISEER1.9912e-02-0.1625image
chr1:10457170-10458044:-COADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.5924e-04-0.2176image
ENSG00000160049.10,DFFADLBCGSVA_HALLMARK_MYOGENESISEAG9.3834e-030.3917image
chr1:10457170-10458044:-DLBCGSVA_HALLMARK_MITOTIC_SPINDLEEER2.2966e-03-0.4631image
chr1:10457170-10458044:-ESCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER2.4331e-040.2862image
chr1:10459768-10462408:-ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.3088e-030.2393image
ENSG00000160049.10,DFFAESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.2284e-050.3111image
chr1:10459768-10462408:-GBMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.4807e-03-0.2376image
ENSG00000160049.10,DFFAGBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.9424e-080.4178image
chr1:10457170-10458044:-GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.3336e-090.4415image
chr1:10459768-10462408:-HNSCGSVA_HALLMARK_MITOTIC_SPINDLEEER1.9217e-08-0.2747image
chr1:10457170-10458044:-HNSCGSVA_HALLMARK_SPERMATOGENESISEER1.2763e-10-0.2866image
ENSG00000160049.10,DFFAHNSCGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.7792e-14-0.3349image
ENSG00000160049.10,DFFAKICHGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG4.0265e-02-0.2571image
chr1:10457170-10458044:-KICHGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER4.4155e-02-0.2525image
chr1:10459768-10462408:-KIRCGSVA_HALLMARK_UV_RESPONSE_DNEER2.5465e-05-0.2367image
chr1:10457170-10458044:-KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.7530e-070.2574image
ENSG00000160049.10,DFFAKIRCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG3.8324e-060.2345image
ENSG00000160049.10,DFFAKIRPGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.3391e-05-0.2410image
chr1:10459768-10462408:-KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEER2.6719e-06-0.3373image
chr1:10457170-10458044:-KIRPGSVA_HALLMARK_UV_RESPONSE_DNEER2.6275e-04-0.2157image
chr1:10459768-10462408:-LAMLGSVA_HALLMARK_DNA_REPAIREER7.5406e-03-0.3083image
chr1:10457170-10458044:-LAMLGSVA_HALLMARK_MYC_TARGETS_V2EER2.0376e-05-0.3643image
ENSG00000160049.10,DFFALAMLGSVA_HALLMARK_MYC_TARGETS_V2EAG2.5410e-05-0.3490image
ENSG00000160049.10,DFFALGGGSVA_HALLMARK_MYOGENESISEAG1.4143e-220.4078image
chr1:10459768-10462408:-LGGGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER8.6044e-060.1966image
chr1:10457170-10458044:-LGGGSVA_HALLMARK_MYC_TARGETS_V2EER7.3982e-24-0.4190image
chr1:10459768-10462408:-LIHCGSVA_HALLMARK_IL2_STAT5_SIGNALINGEER3.9177e-050.3312image
chr1:10457170-10458044:-LIHCGSVA_HALLMARK_MITOTIC_SPINDLEEER6.2740e-08-0.2866image
ENSG00000160049.10,DFFALIHCGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.9288e-07-0.2690image
ENSG00000160049.10,DFFALUADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.5481e-050.1894image
chr1:10457170-10458044:-LUADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.9285e-070.2289image
ENSG00000160049.10,DFFALUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.5153e-210.4088image
chr1:10457170-10458044:-LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.4919e-240.4367image
ENSG00000160049.10,DFFAMESOGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG2.3287e-030.3358image
chr1:10457170-10458044:-MESOGSVA_HALLMARK_APOPTOSISEER4.8492e-030.3120image
chr1:10459768-10462408:-MESOGSVA_HALLMARK_COAGULATIONEER2.0483e-030.4342image
ENSG00000160049.10,DFFAOVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.8390e-120.3970image
chr1:10459768-10462408:-OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER6.6914e-060.2610image
chr1:10457170-10458044:-OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.5882e-140.4240image
chr1:10459768-10462408:-PAADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.3228e-020.2422image
chr1:10457170-10458044:-PAADGSVA_HALLMARK_UV_RESPONSE_DNEER1.9825e-02-0.1770image
ENSG00000160049.10,DFFAPAADGSVA_HALLMARK_UV_RESPONSE_DNEAG6.0450e-03-0.2079image
ENSG00000160049.10,DFFAPCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.4179e-050.3217image
chr1:10459768-10462408:-PCPGGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.4703e-020.2623image
chr1:10457170-10458044:-PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2878e-050.3232image
ENSG00000160049.10,DFFAPRADGSVA_HALLMARK_PROTEIN_SECRETIONEAG3.4662e-11-0.2912image
chr1:10459768-10462408:-PRADGSVA_HALLMARK_MITOTIC_SPINDLEEER6.6212e-06-0.2285image
chr1:10457170-10458044:-PRADGSVA_HALLMARK_PROTEIN_SECRETIONEER2.1268e-09-0.2642image
chr1:10459768-10462408:-READGSVA_HALLMARK_PANCREAS_BETA_CELLSEER3.6392e-020.2344image
chr1:10457170-10458044:-READGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER4.8376e-03-0.2883image
ENSG00000160049.10,DFFAREADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG7.3732e-03-0.2733image
ENSG00000160049.10,DFFASARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.4580e-080.3449image
chr1:10459768-10462408:-SARCGSVA_HALLMARK_G2M_CHECKPOINTEER3.5329e-04-0.2420image
chr1:10457170-10458044:-SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.3332e-060.2817image
chr1:10457170-10458044:-SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2447e-070.2432image
chr1:10459768-10462408:-SKCMGSVA_HALLMARK_MITOTIC_SPINDLEEER1.6361e-05-0.2118image
ENSG00000160049.10,DFFASKCMGSVA_HALLMARK_MITOTIC_SPINDLEEAG5.2734e-09-0.2668image
ENSG00000160049.10,DFFASTADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.1734e-070.2648image
chr1:10457170-10458044:-STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.4726e-080.2819image
chr1:10459768-10462408:-STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.4717e-050.2250image
ENSG00000160049.10,DFFATGCTGSVA_HALLMARK_GLYCOLYSISEAG1.4127e-05-0.3420image
chr1:10457170-10458044:-TGCTGSVA_HALLMARK_GLYCOLYSISEER3.2443e-06-0.3650image
chr1:10459768-10462408:-TGCTGSVA_HALLMARK_G2M_CHECKPOINTEER9.4696e-03-0.2294image
chr1:10457170-10458044:-THCAGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.8613e-050.1904image
ENSG00000160049.10,DFFATHCAGSVA_HALLMARK_UV_RESPONSE_DNEAG5.8865e-07-0.2209image
chr1:10459768-10462408:-THCAGSVA_HALLMARK_UV_RESPONSE_DNEER7.0272e-04-0.1608image
chr1:10459768-10462408:-THYMGSVA_HALLMARK_PROTEIN_SECRETIONEER2.4736e-04-0.4062image
ENSG00000160049.10,DFFATHYMGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.2046e-09-0.5160image
chr1:10457170-10458044:-THYMGSVA_HALLMARK_MITOTIC_SPINDLEEER1.2840e-07-0.4723image
chr1:10459768-10462408:-UCECGSVA_HALLMARK_MITOTIC_SPINDLEEER4.1969e-05-0.3551image
chr1:10457170-10458044:-UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.3196e-060.3411image
ENSG00000160049.10,DFFAUCECGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG2.3712e-05-0.3154image
chr1:10457170-10458044:-UCSGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.9724e-040.4856image
ENSG00000160049.10,DFFAUCSGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.6023e-040.4875image
ENSG00000160049.10,DFFAUVMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.5953e-040.4199image
chr1:10457170-10458044:-UVMGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.5962e-040.4225image


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7. Enriched editing regions and drugs for DFFA


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000160049.10,DFFAACCABT.263EAG1.2783e-030.3699image
chr1:10457170-10458044:-ACCABT.263EER1.2829e-030.3698image
chr1:10457170-10458044:-BLCACGP.60474EER2.1732e-16-0.3973image
chr1:10459768-10462408:-BLCAGDC.0449EER7.9250e-05-0.2195image
ENSG00000160049.10,DFFABLCACGP.60474EAG3.9615e-16-0.3937image
chr1:10457170-10458044:-BRCAAxitinibEER1.6650e-050.1307image
chr1:10459768-10462408:-BRCAA.770041EER6.5867e-04-0.1096image
ENSG00000160049.10,DFFABRCAAxitinibEAG1.5322e-050.1312image
chr1:10459768-10462408:-CESCBryostatin.1EER6.3814e-04-0.2133image
chr1:10457170-10458044:-CESCBMS.536924EER6.7951e-11-0.3692image
ENSG00000160049.10,DFFACESCBMS.536924EAG6.6518e-13-0.4010image
ENSG00000160049.10,DFFACHOLErlotinibEAG1.6392e-02-0.4087image
chr1:10457170-10458044:-CHOLBI.2536EER9.2621e-030.4397image
ENSG00000160049.10,DFFACOADCCT007093EAG3.6937e-05-0.2488image
chr1:10459768-10462408:-COADLFM.A13EER1.1776e-03-0.2250image
chr1:10457170-10458044:-COADGW843682XEER1.9455e-060.2875image
ENSG00000160049.10,DFFADLBCGNF.2EAG7.5555e-06-0.6247image
chr1:10457170-10458044:-DLBCGNF.2EER1.0582e-06-0.6790image
chr1:10457170-10458044:-ESCACGP.60474EER1.1563e-04-0.3001image
chr1:10459768-10462408:-ESCAAZD.2281EER2.1468e-04-0.2895image
ENSG00000160049.10,DFFAESCACGP.60474EAG3.6496e-05-0.3203image
chr1:10457170-10458044:-GBMBIBW2992EER1.5437e-10-0.4695image
ENSG00000160049.10,DFFAGBMBIBW2992EAG7.0044e-10-0.4542image
chr1:10459768-10462408:-GBMBIBW2992EER1.0042e-02-0.2030image
chr1:10459768-10462408:-HNSCBAY.61.3606EER2.5491e-060.2313image
chr1:10457170-10458044:-HNSCAZD6244EER5.5819e-16-0.3568image
ENSG00000160049.10,DFFAHNSCAZD6244EAG1.6624e-16-0.3614image
ENSG00000160049.10,DFFAKICHLenalidomideEAG3.6013e-03-0.3588image
chr1:10457170-10458044:-KICHLenalidomideEER2.3659e-03-0.3735image
ENSG00000160049.10,DFFAKIRCCI.1040EAG5.3685e-14-0.3731image
chr1:10459768-10462408:-KIRCA.770041EER1.3678e-08-0.3155image
chr1:10457170-10458044:-KIRCCI.1040EER1.5240e-11-0.3374image
ENSG00000160049.10,DFFAKIRPAZD6482EAG5.3162e-050.2382image
chr1:10459768-10462408:-KIRPGSK269962AEER2.5009e-03-0.2216image
chr1:10457170-10458044:-KIRPAZD6482EER1.1241e-050.2582image
chr1:10459768-10462408:-LAMLCytarabineEER8.5948e-040.3793image
chr1:10457170-10458044:-LAMLBAY.61.3606EER8.7922e-060.3789image
ENSG00000160049.10,DFFALAMLBAY.61.3606EAG3.8559e-060.3804image
chr1:10459768-10462408:-LGGEmbelinEER1.2608e-100.2811image
ENSG00000160049.10,DFFALGGGSK.650394EAG4.8180e-290.4603image
chr1:10457170-10458044:-LGGGSK.650394EER7.3748e-340.4942image
chr1:10457170-10458044:-LIHCBAY.61.3606EER1.6283e-090.3179image
chr1:10459768-10462408:-LIHCBMS.536924EER4.3816e-02-0.1677image
ENSG00000160049.10,DFFALIHCGSK.650394EAG1.4722e-070.2784image
ENSG00000160049.10,DFFALUADGefitinibEAG8.7451e-04-0.1468image
chr1:10457170-10458044:-LUADGefitinibEER5.0831e-04-0.1545image
chr1:10459768-10462408:-LUADBI.D1870EER1.3604e-020.1213image
ENSG00000160049.10,DFFALUSCCI.1040EAG4.2003e-08-0.2436image
chr1:10457170-10458044:-LUSCCI.1040EER2.8416e-08-0.2470image
ENSG00000160049.10,DFFAMESOLFM.A13EAG5.8963e-03-0.3053image
chr1:10457170-10458044:-MESODasatinibEER3.0032e-02-0.2428image
chr1:10459768-10462408:-MESOAZD.0530EER1.1607e-05-0.5870image
ENSG00000160049.10,DFFAOVBexaroteneEAG1.7392e-120.3974image
chr1:10459768-10462408:-OVBexaroteneEER1.2324e-090.3471image
chr1:10457170-10458044:-OVBexaroteneEER2.6791e-090.3393image
chr1:10459768-10462408:-PAADAZD6482EER2.5833e-020.2229image
chr1:10457170-10458044:-PAADGSK.650394EER1.4750e-030.2434image
ENSG00000160049.10,DFFAPAADGSK.650394EAG2.7323e-030.2298image
ENSG00000160049.10,DFFAPCPGEmbelinEAG7.9710e-070.3629image
chr1:10457170-10458044:-PCPGMidostaurinEER9.5207e-070.3606image
chr1:10459768-10462408:-PCPGAZD6244EER7.6540e-04-0.3561image
ENSG00000160049.10,DFFAPRADBAY.61.3606EAG4.9996e-140.3289image
chr1:10459768-10462408:-PRADBAY.61.3606EER2.4290e-050.2144image
chr1:10457170-10458044:-PRADBAY.61.3606EER1.3558e-120.3105image
chr1:10459768-10462408:-READDoxorubicinEER1.6394e-030.3465image
chr1:10457170-10458044:-READKU.55933EER1.3966e-05-0.4317image
ENSG00000160049.10,DFFAREADKU.55933EAG6.6306e-06-0.4438image
ENSG00000160049.10,DFFASARCAG.014699EAG1.4506e-060.2958image
chr1:10457170-10458044:-SARCGDC.0449EER7.7056e-07-0.3048image
chr1:10459768-10462408:-SARCGNF.2EER1.7854e-05-0.2887image
chr1:10457170-10458044:-SKCMGNF.2EER2.5298e-12-0.3184image
chr1:10459768-10462408:-SKCMBAY.61.3606EER1.5286e-040.1866image
ENSG00000160049.10,DFFASKCMGNF.2EAG1.7932e-14-0.3457image
ENSG00000160049.10,DFFASTADCI.1040EAG5.2215e-05-0.2081image
chr1:10457170-10458044:-STADCI.1040EER1.4679e-05-0.2232image
chr1:10459768-10462408:-STADCisplatinEER2.3652e-05-0.2196image
ENSG00000160049.10,DFFATGCTDocetaxelEAG9.4503e-060.3485image
chr1:10457170-10458044:-TGCTDocetaxelEER1.8177e-060.3736image
chr1:10459768-10462408:-TGCTAG.014699EER1.8114e-030.2742image
chr1:10457170-10458044:-THCAEmbelinEER4.6822e-380.5335image
ENSG00000160049.10,DFFATHCAEmbelinEAG6.6852e-410.5497image
chr1:10459768-10462408:-THCAEmbelinEER4.0438e-120.3223image
chr1:10459768-10462408:-THYMAxitinibEER4.3264e-05-0.4484image
ENSG00000160049.10,DFFATHYMBAY.61.3606EAG1.2445e-150.6608image
chr1:10457170-10458044:-THYMBAY.61.3606EER1.9781e-110.5783image
chr1:10459768-10462408:-UCECJNK.9LEER2.3770e-070.4393image
chr1:10457170-10458044:-UCECFH535EER2.4471e-070.3835image
ENSG00000160049.10,DFFAUCECFH535EAG6.5825e-110.4704image
chr1:10457170-10458044:-UCSCGP.60474EER4.7118e-05-0.5243image
chr1:10459768-10462408:-UCSA.443654EER3.1746e-02-0.3012image
ENSG00000160049.10,DFFAUCSCGP.60474EAG3.8768e-05-0.5250image
ENSG00000160049.10,DFFAUVMEmbelinEAG2.5174e-050.4632image
chr1:10457170-10458044:-UVMEmbelinEER2.4653e-050.4664image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType