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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ZNF780B (ImmuneEditome ID:163131)

1. Gene summary of enriched editing regions for ZNF780B

check button Gene summary
Gene informationGene symbol

ZNF780B

Gene ID

163131

GeneSynonymsZNF779
GeneCytomap

19q13.2

GeneTypeprotein-coding
GeneDescriptionzinc finger protein 780B|zinc finger protein 779
GeneModificationdate20230517
UniprotIDQ9Y6R6;C9JTJ1;M0R0W9;M0R168
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr19:40031207-40032704:-ENST00000434248.4ENSG00000128000.14ZNF780BUTR3AluY,(TTCAATT)n,MER5A,L2a,AluSx,L1MC4chr19:40031207-40032704:-.alignment
chr19:40031207-40032704:-ENST00000617676.3ENSG00000128000.14ZNF780BUTR3AluY,(TTCAATT)n,MER5A,L2a,AluSx,L1MC4chr19:40031207-40032704:-.alignment
chr19:40035939-40037157:-ENST00000221355.9ENSG00000128000.14ZNF780BexonicMER5A,AluSq2chr19:40035939-40037157:-.alignment
chr19:40035939-40037157:-ENST00000434248.4ENSG00000128000.14ZNF780BexonicMER5A,AluSq2chr19:40035939-40037157:-.alignment
chr19:40035939-40037157:-ENST00000595995.4ENSG00000128000.14ZNF780BexonicMER5A,AluSq2chr19:40035939-40037157:-.alignment
chr19:40035939-40037157:-ENST00000598845.4ENSG00000128000.14ZNF780BexonicMER5A,AluSq2chr19:40035939-40037157:-.alignment
chr19:40035939-40037157:-ENST00000617676.3ENSG00000128000.14ZNF780BexonicMER5A,AluSq2chr19:40035939-40037157:-.alignment
chr19:40045333-40045659:-ENST00000221355.9ENSG00000128000.14ZNF780BintronicL1MA4Achr19:40045333-40045659:-.alignment
chr19:40045333-40045659:-ENST00000434248.4ENSG00000128000.14ZNF780BintronicL1MA4Achr19:40045333-40045659:-.alignment
chr19:40045333-40045659:-ENST00000595995.4ENSG00000128000.14ZNF780BintronicL1MA4Achr19:40045333-40045659:-.alignment
chr19:40045333-40045659:-ENST00000598845.4ENSG00000128000.14ZNF780BintronicL1MA4Achr19:40045333-40045659:-.alignment
chr19:40045333-40045659:-ENST00000617676.3ENSG00000128000.14ZNF780BintronicL1MA4Achr19:40045333-40045659:-.alignment


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2. Tumor-specific enriched editing regions for ZNF780B


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr19:40031207-40032704:-BRCAEER2.3988e-11image
ENSG00000128000.14,ZNF780BBRCAEAG2.0971e-11image
chr19:40031207-40032704:-LUSCEER3.7644e-02image
ENSG00000128000.14,ZNF780BLUSCEAG3.7247e-02image
chr19:40031207-40032704:-THCAEER1.0195e-05image
ENSG00000128000.14,ZNF780BTHCAEAG1.9442e-05image
chr19:40031207-40032704:-UCECEER4.1079e-05image
ENSG00000128000.14,ZNF780BUCECEAG7.1743e-05image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000128000.14,ZNF780BKICHPathEAG1.2195e-022.1530e-020.3039image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000128000.14,ZNF780BCESCEAG3.3932e-031.8600e-025.1218e+01image

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3. Enriched editing regions and immune related genes for ZNF780B


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:40031207-40032704:-THYMEERENSG00000021762,OSBPL5-0.51324.8477e-062.1894e-08-0.4929imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_G2M_CHECKPOINT
chr19:40031207-40032704:-THYMEERENSG00000231062,AC103563.9-0.48345.5741e-068.6450e-08-0.4742imageNNNAT_cells_CD4_naiveGSVA_HALLMARK_G2M_CHECKPOINT
chr19:40031207-40032704:-THYMEERENSG00000266947,RP11-799D4.4-0.49098.5700e-061.1615e-08-0.5012imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_E2F_TARGETS
chr19:40031207-40032704:-THYMEERENSG00000183688,FAM101B-0.50901.0012e-053.5750e-07-0.4536imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_G2M_CHECKPOINT
chr19:40031207-40032704:-THYMEERENSG00000183134,PTGDR2-0.49191.5202e-057.9918e-07-0.4412imageNNPTGDR2T_cells_regulatory_(Tregs)GSVA_HALLMARK_E2F_TARGETS
chr19:40031207-40032704:-THYMEERENSG00000140398,NEIL1-0.47081.8925e-051.4092e-07-0.4672imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr19:40031207-40032704:-THYMEERENSG00000266074,BAHCC1-0.49171.9478e-051.3789e-07-0.4675imageNNNAT_cells_CD4_naiveGSVA_HALLMARK_G2M_CHECKPOINT
chr19:40031207-40032704:-THYMEERENSG00000248890,HHIP-AS1-0.48732.0602e-058.0516e-08-0.4752imageNNNAT_cells_CD4_naiveGSVA_HALLMARK_E2F_TARGETS
chr19:40031207-40032704:-THYMEERENSG00000273893,RP1-101A2.1-0.47342.7004e-057.0840e-09-0.5075imageNNNAMacrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr19:40031207-40032704:-THYMEERENSG00000166963,MAP1A-0.48062.7682e-051.6302e-07-0.4651imageNNNAMacrophages_M1GSVA_HALLMARK_E2F_TARGETS
chr19:40031207-40032704:-THYMEERENSG00000021762,OSBPL5-0.51324.8477e-062.1894e-08-0.4929imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_G2M_CHECKPOINT
chr19:40031207-40032704:-THYMEERENSG00000231062,AC103563.9-0.48345.5741e-068.6450e-08-0.4742imageNNNAT_cells_CD4_naiveGSVA_HALLMARK_G2M_CHECKPOINT
chr19:40031207-40032704:-THYMEERENSG00000266947,RP11-799D4.4-0.49098.5700e-061.1615e-08-0.5012imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_E2F_TARGETS
chr19:40031207-40032704:-THYMEERENSG00000183688,FAM101B-0.50901.0012e-053.5750e-07-0.4536imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_G2M_CHECKPOINT
chr19:40031207-40032704:-THYMEERENSG00000183134,PTGDR2-0.49191.5202e-057.9918e-07-0.4412imageNNPTGDR2T_cells_regulatory_(Tregs)GSVA_HALLMARK_E2F_TARGETS
chr19:40031207-40032704:-THYMEERENSG00000140398,NEIL1-0.47081.8925e-051.4092e-07-0.4672imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr19:40031207-40032704:-THYMEERENSG00000266074,BAHCC1-0.49171.9478e-051.3789e-07-0.4675imageNNNAT_cells_CD4_naiveGSVA_HALLMARK_G2M_CHECKPOINT
chr19:40031207-40032704:-THYMEERENSG00000248890,HHIP-AS1-0.48732.0602e-058.0516e-08-0.4752imageNNNAT_cells_CD4_naiveGSVA_HALLMARK_E2F_TARGETS
chr19:40031207-40032704:-THYMEERENSG00000273893,RP1-101A2.1-0.47342.7004e-057.0840e-09-0.5075imageNNNAMacrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr19:40031207-40032704:-THYMEERENSG00000166963,MAP1A-0.48062.7682e-051.6302e-07-0.4651imageNNNAMacrophages_M1GSVA_HALLMARK_E2F_TARGETS

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4. Enriched editing regions and immune related splicing for ZNF780B


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000128000.14,ZNF780B
ESCAEAGIRENSG00000133142.13chrX103585491:103585683:103586218:103586291-0.33861.8083e-026.5141e-06-0.4508imageNACIN1;AIFM1;AUH;BCCIP;BUD13;CNBP;CSTF2T;DDX54;DGCR8;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;LARP4B;LIN28A;LIN28B;MBNL2;MOV10;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TIA1;TRA2A;U2AF1;U2AF2;UPF1;VIM;YTHDC1;YTHDF1;ZNF184NAMast_cells_restingGSVA_HALLMARK_APICAL_SURFACE
ENSG00000128000.14,ZNF780B
ESCAEAGA5ENSG00000213903.4chr1424315636:24315688:24314699:24315016:24314699:243150200.33414.9435e-024.4610e-060.4367imageNADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX54;DGCR8;DHX9;DICER1;EIF4A3;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184LTB4RB_cells_naiveGSVA_HALLMARK_KRAS_SIGNALING_DN
ENSG00000128000.14,ZNF780B
ESCAEAGIRENSG00000103495.9chr1629808050:29808293:29808430:29808741-0.32973.7233e-021.7363e-06-0.4414imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184MAZB_cells_naiveGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr19:40031207-40032704:-
GBMEERIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.35624.4506e-032.4069e-07-0.4030imageNNPRKCSHMacrophages_M0GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000128000.14,ZNF780B
GBMEAGIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.35625.1540e-032.4069e-07-0.4030imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184PRKCSHMacrophages_M0GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000128000.14,ZNF780B
PCPGEAGIRENSG00000133142.13chrX103585504:103585624:103585969:103586291-0.25001.0258e-028.6965e-09-0.4294imageNACIN1;AIFM1;AUH;BCCIP;BUD13;CNBP;CSTF2T;DDX54;DGCR8;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;LARP4B;LIN28A;LIN28B;MBNL2;MOV10;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TIA1;TRA2A;U2AF1;U2AF2;UPF1;VIM;YTHDC1;YTHDF1;ZNF184NAT_cells_CD4_memory_activatedGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr19:40031207-40032704:-
THYMEERESENSG00000198814.8chrX30724100:30724181:30727465:30727552:30728731:30729170-0.40141.4048e-031.6931e-08-0.5521imageNNNAMacrophages_M1GSVA_HALLMARK_E2F_TARGETS
ENSG00000128000.14,ZNF780B
THYMEAGIRENSG00000106624.4chr744110724:44110809:44110912:44111057-0.36931.3617e-023.2909e-06-0.4252imageNCELF2;CPSF6;CSTF2T;DKC1;EIF4A3;EWSR1;FBL;FUS;HNRNPA2B1;HNRNPK;HNRNPL;IGF2BP2;IGF2BP3;ILF3;LIN28A;MBNL2;MSI2;NOP56;PRPF8;RBFOX2;SF3B4;TAF15;TARDBP;UPF1;YTHDC1AEBP1Macrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
ENSG00000128000.14,ZNF780B
THYMEAGESENSG00000001497.12chrX65524055:65524262:65524563:65524614:65524964:65525046-0.45771.0009e-036.1489e-07-0.4489imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_G2M_CHECKPOINT
ENSG00000128000.14,ZNF780B
THYMEAGIRENSG00000064601.12chr2045890143:45891762:45891915:45892027-0.34343.4509e-025.4173e-06-0.4201imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184CTSAMacrophages_M1GSVA_HALLMARK_HYPOXIA

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5. Enriched editing regions and immune infiltration for ZNF780B


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000128000.14,ZNF780BBLCAEAGT_cells_CD4_memory_activated7.7250e-050.2273image
chr19:40031207-40032704:-BRCAEERNeutrophils2.2842e-040.1288image
ENSG00000128000.14,ZNF780BBRCAEAGNeutrophils3.8994e-040.1233image
ENSG00000128000.14,ZNF780BCHOLEAGMacrophages_M24.1489e-030.5529image
ENSG00000128000.14,ZNF780BDLBCEAGT_cells_gamma_delta4.8383e-02-0.3141image
chr19:40045333-40045659:-ESCAEERNK_cells_resting2.3893e-020.4184image
ENSG00000128000.14,ZNF780BESCAEAGB_cells_naive5.5283e-04-0.3046image
ENSG00000128000.14,ZNF780BHNSCEAGNK_cells_resting3.2326e-030.2344image
ENSG00000128000.14,ZNF780BKICHEAGB_cells_memory3.7259e-050.5177image
ENSG00000128000.14,ZNF780BKIRCEAGT_cells_regulatory_(Tregs)2.6031e-020.1422image
ENSG00000128000.14,ZNF780BKIRPEAGNK_cells_activated3.3019e-02-0.1520image
ENSG00000128000.14,ZNF780BLAMLEAGMast_cells_resting2.2248e-030.3117image
ENSG00000128000.14,ZNF780BLGGEAGMacrophages_M02.9116e-02-0.0976image
ENSG00000128000.14,ZNF780BLIHCEAGEosinophils3.3461e-02-0.1911image
ENSG00000128000.14,ZNF780BLUADEAGT_cells_CD4_memory_resting2.1242e-04-0.2300image
chr19:40031207-40032704:-LUSCEERT_cells_CD4_memory_activated9.5599e-030.1444image
ENSG00000128000.14,ZNF780BLUSCEAGT_cells_CD4_memory_activated9.3495e-030.1449image
ENSG00000128000.14,ZNF780BMESOEAGEosinophils3.0089e-02-0.2901image
chr19:40031207-40032704:-OVEERT_cells_regulatory_(Tregs)2.8794e-020.1409image
ENSG00000128000.14,ZNF780BOVEAGT_cells_regulatory_(Tregs)2.7161e-020.1417image
ENSG00000128000.14,ZNF780BPAADEAGMast_cells_activated9.6818e-030.2324image
chr19:40031207-40032704:-PCPGEERMast_cells_resting8.8855e-03-0.1956image
ENSG00000128000.14,ZNF780BPCPGEAGMast_cells_resting6.9594e-03-0.2016image
chr19:40031207-40032704:-PRADEERT_cells_follicular_helper6.1565e-04-0.1584image
ENSG00000128000.14,ZNF780BPRADEAGT_cells_follicular_helper5.5247e-04-0.1596image
ENSG00000128000.14,ZNF780BSARCEAGMast_cells_resting3.5695e-020.1517image
chr19:40031207-40032704:-SKCMEERMast_cells_activated4.8704e-02-0.1121image
ENSG00000128000.14,ZNF780BSKCMEAGMast_cells_activated4.8566e-02-0.1121image
chr19:40031207-40032704:-STADEERNK_cells_resting1.6141e-030.2072image
chr19:40045333-40045659:-STADEERT_cells_CD4_memory_activated2.5773e-020.3568image
ENSG00000128000.14,ZNF780BSTADEAGNK_cells_resting5.9241e-030.1798image
chr19:40031207-40032704:-THCAEERDendritic_cells_activated4.9371e-050.1838image
ENSG00000128000.14,ZNF780BTHCAEAGDendritic_cells_activated4.8266e-050.1838image
chr19:40031207-40032704:-THYMEERT_cells_gamma_delta3.6629e-070.4532image
ENSG00000128000.14,ZNF780BTHYMEAGT_cells_gamma_delta4.0967e-070.4515image
ENSG00000128000.14,ZNF780BUCSEAGB_cells_naive1.4625e-02-0.3504image


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6. Enriched editing regions and immune gene sets for ZNF780B


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
ENSG00000128000.14,ZNF780BBLCAEAG1.0571e-02image1.1439e-070.3017image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000128000.14,ZNF780BLUADEAG6.2272e-050.24801.9515e-020.14621.0182e-020.16074.1158e-060.2838image
ENSG00000128000.14,ZNF780BSTADEAG6.7933e-060.29001.4683e-030.20729.0865e-070.31521.1794e-030.2112image
chr19:40031207-40032704:-STADEER2.1226e-060.30741.1764e-030.21313.2560e-070.32991.8120e-030.2051image
ENSG00000128000.14,ZNF780BUCSEAG2.4475e-020.32443.4418e-020.30602.7155e-020.31898.0388e-040.4676image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000128000.14,ZNF780BACCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG3.4711e-020.2709image
ENSG00000128000.14,ZNF780BBLCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG6.7068e-090.3284image
ENSG00000128000.14,ZNF780BBRCAGSVA_HALLMARK_PEROXISOMEEAG1.2078e-080.1969image
chr19:40031207-40032704:-BRCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.2030e-070.1803image
ENSG00000128000.14,ZNF780BCESCGSVA_HALLMARK_ADIPOGENESISEAG3.2947e-030.2173image
ENSG00000128000.14,ZNF780BCHOLGSVA_HALLMARK_ADIPOGENESISEAG4.4058e-030.5499image
ENSG00000128000.14,ZNF780BCOADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.7319e-030.2465image
ENSG00000128000.14,ZNF780BESCAGSVA_HALLMARK_HYPOXIAEAG2.9228e-020.1951image
chr19:40045333-40045659:-ESCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER3.0824e-02-0.4016image
chr19:40031207-40032704:-GBMGSVA_HALLMARK_HEME_METABOLISMEER4.4932e-030.2256image
ENSG00000128000.14,ZNF780BGBMGSVA_HALLMARK_HEME_METABOLISMEAG4.4932e-030.2256image
ENSG00000128000.14,ZNF780BHNSCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG2.7412e-040.2875image
ENSG00000128000.14,ZNF780BKICHGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.2200e-02-0.3299image
ENSG00000128000.14,ZNF780BKIRCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG3.5748e-040.2262image
ENSG00000128000.14,ZNF780BKIRPGSVA_HALLMARK_HEME_METABOLISMEAG5.6405e-030.1965image
ENSG00000128000.14,ZNF780BLGGGSVA_HALLMARK_HEME_METABOLISMEAG1.9894e-040.1656image
ENSG00000128000.14,ZNF780BLIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG2.2685e-040.3253image
ENSG00000128000.14,ZNF780BLUADGSVA_HALLMARK_HYPOXIAEAG4.1158e-060.2838image
chr19:40031207-40032704:-LUSCGSVA_HALLMARK_UV_RESPONSE_UPEER1.9986e-050.2356image
ENSG00000128000.14,ZNF780BLUSCGSVA_HALLMARK_UV_RESPONSE_UPEAG2.0040e-050.2356image
chr19:40031207-40032704:-OVGSVA_HALLMARK_SPERMATOGENESISEER4.0900e-02-0.1318image
ENSG00000128000.14,ZNF780BPAADGSVA_HALLMARK_GLYCOLYSISEAG2.2772e-030.2727image
chr19:40031207-40032704:-PCPGGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER5.8723e-030.2057image
ENSG00000128000.14,ZNF780BPCPGGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG2.8603e-030.2223image
ENSG00000128000.14,ZNF780BPRADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.0253e-020.1190image
chr19:40031207-40032704:-PRADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.4194e-020.1138image
ENSG00000128000.14,ZNF780BREADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG2.7442e-020.3059image
ENSG00000128000.14,ZNF780BSARCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG4.9711e-020.1418image
ENSG00000128000.14,ZNF780BSKCMGSVA_HALLMARK_APOPTOSISEAG1.5536e-040.2132image
chr19:40031207-40032704:-SKCMGSVA_HALLMARK_APOPTOSISEER1.4835e-040.2138image
ENSG00000128000.14,ZNF780BSTADGSVA_HALLMARK_GLYCOLYSISEAG9.3526e-070.3148image
chr19:40031207-40032704:-STADGSVA_HALLMARK_GLYCOLYSISEER1.5972e-060.3109image
ENSG00000128000.14,ZNF780BTGCTGSVA_HALLMARK_PEROXISOMEEAG3.4935e-020.1741image
chr19:40031207-40032704:-THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER1.6884e-070.2355image
ENSG00000128000.14,ZNF780BTHCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG1.5518e-070.2360image
chr19:40031207-40032704:-THYMGSVA_HALLMARK_HYPOXIAEER5.5854e-050.3666image
ENSG00000128000.14,ZNF780BTHYMGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG5.2702e-050.3678image
chr19:40031207-40032704:-UCECGSVA_HALLMARK_COAGULATIONEER1.5245e-020.2070image
ENSG00000128000.14,ZNF780BUCECGSVA_HALLMARK_COAGULATIONEAG4.0840e-030.2396image
ENSG00000128000.14,ZNF780BUCSGSVA_HALLMARK_GLYCOLYSISEAG1.2687e-040.5252image


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7. Enriched editing regions and drugs for ZNF780B


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000128000.14,ZNF780BBLCAKU.55933EAG1.5339e-10-0.3604image
ENSG00000128000.14,ZNF780BBRCAAP.24534EAG3.6496e-060.1605image
chr19:40031207-40032704:-BRCAAP.24534EER1.3084e-050.1520image
ENSG00000128000.14,ZNF780BCESCCI.1040EAG3.0065e-03-0.2194image
ENSG00000128000.14,ZNF780BCHOLBIRB.0796EAG7.7285e-030.5199image
ENSG00000128000.14,ZNF780BCOADBMS.509744EAG3.9132e-03-0.2276image
ENSG00000128000.14,ZNF780BESCAAZD.2281EAG1.9714e-04-0.3283image
chr19:40045333-40045659:-ESCALFM.A13EER2.5208e-02-0.4149image
ENSG00000128000.14,ZNF780BGBMAZD6244EAG4.7748e-030.2241image
chr19:40031207-40032704:-GBMAZD6244EER4.7748e-030.2241image
ENSG00000128000.14,ZNF780BHNSCAZD6244EAG6.8252e-05-0.3133image
ENSG00000128000.14,ZNF780BKICHDoxorubicinEAG1.1559e-03-0.4196image
ENSG00000128000.14,ZNF780BKIRCCI.1040EAG6.9549e-05-0.2513image
ENSG00000128000.14,ZNF780BKIRPCCT018159EAG1.3026e-030.2275image
ENSG00000128000.14,ZNF780BLGGDocetaxelEAG2.1700e-040.1647image
ENSG00000128000.14,ZNF780BLIHCGW.441756EAG8.1982e-04-0.2967image
ENSG00000128000.14,ZNF780BLUADCGP.60474EAG1.2709e-02-0.1559image
chr19:40031207-40032704:-LUSCCI.1040EER5.3757e-05-0.2234image
ENSG00000128000.14,ZNF780BLUSCCI.1040EAG5.8657e-05-0.2223image
ENSG00000128000.14,ZNF780BOVAS601245EAG1.1806e-02-0.1613image
chr19:40031207-40032704:-OVAS601245EER1.3778e-02-0.1585image
ENSG00000128000.14,ZNF780BPAADAICAREAG2.7495e-020.1988image
chr19:40031207-40032704:-PCPGBI.D1870EER2.5512e-020.1674image
ENSG00000128000.14,ZNF780BPCPGBI.D1870EAG2.5390e-020.1676image
chr19:40031207-40032704:-PRADBIBW2992EER3.6007e-030.1349image
ENSG00000128000.14,ZNF780BPRADBIBW2992EAG4.0715e-030.1330image
ENSG00000128000.14,ZNF780BREADEmbelinEAG2.2503e-02-0.3159image
ENSG00000128000.14,ZNF780BSARCAKT.inhibitor.VIIIEAG8.4334e-03-0.1896image
chr19:40031207-40032704:-SKCMErlotinibEER1.4325e-040.2143image
ENSG00000128000.14,ZNF780BSKCMErlotinibEAG1.4359e-040.2143image
chr19:40045333-40045659:-STADCMKEER2.7772e-02-0.3524image
ENSG00000128000.14,ZNF780BSTADLenalidomideEAG1.0293e-050.2845image
chr19:40031207-40032704:-STADLenalidomideEER1.4709e-050.2820image
ENSG00000128000.14,ZNF780BTGCTAUY922EAG3.8649e-020.1708image
ENSG00000128000.14,ZNF780BTHCAABT.263EAG3.2147e-100.2811image
chr19:40031207-40032704:-THCAABT.263EER1.1676e-090.2726image
chr19:40031207-40032704:-THYMIPA.3EER3.6410e-100.5429image
ENSG00000128000.14,ZNF780BTHYMIPA.3EAG2.5100e-100.5471image
chr19:40031207-40032704:-UCECA.770041EER7.4784e-04-0.2847image
ENSG00000128000.14,ZNF780BUCECA.770041EAG1.3325e-03-0.2667image
ENSG00000128000.14,ZNF780BUCSJNK.9LEAG7.0843e-050.5414image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType