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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ZNF600 (ImmuneEditome ID:162966)

1. Gene summary of enriched editing regions for ZNF600

check button Gene summary
Gene informationGene symbol

ZNF600

Gene ID

162966

GeneSynonymsKR-ZNF1
GeneCytomap

19q13.41

GeneTypeprotein-coding
GeneDescriptionzinc finger protein 600|zinc finger protein KR-ZNF1
GeneModificationdate20230518
UniprotIDQ6ZNG1;A0A3B3IT03;A0A3B3ITY9;A0A3B3ITH4
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr19:52764259-52765036:-ENST00000338230.3ENSG00000189190.8ZNF600UTR3AluYj4,AluSx,AluSzchr19:52764259-52765036:-.alignment
chr19:52764259-52765036:-ENST00000360272.5ENSG00000189190.8ZNF600UTR3AluYj4,AluSx,AluSzchr19:52764259-52765036:-.alignment
chr19:52783482-52785437:-ENST00000594028.1ENSG00000189190.8ZNF600ncRNA_intronicAluSp,AluY,AluJb,AluJochr19:52783482-52785437:-.alignment
chr19:52783482-52785437:-ENST00000597124.1ENSG00000189190.8ZNF600ncRNA_intronicAluSp,AluY,AluJb,AluJochr19:52783482-52785437:-.alignment
chr19:52783482-52785437:-ENST00000598369.1ENSG00000189190.8ZNF600ncRNA_intronicAluSp,AluY,AluJb,AluJochr19:52783482-52785437:-.alignment
chr19:52783482-52785437:-ENST00000599893.1ENSG00000189190.8ZNF600ncRNA_intronicAluSp,AluY,AluJb,AluJochr19:52783482-52785437:-.alignment
chr19:52795610-52795852:-ENST00000360272.5ENSG00000189190.8ZNF600intronicAluSx1chr19:52795610-52795852:-.alignment


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2. Tumor-specific enriched editing regions for ZNF600


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000189190.8,ZNF600STADPathEAG3.3162e-037.1950e-03-0.1764image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000189190.8,ZNF600CESCEAG1.6945e-051.0167e-031.4082e+03image
ENSG00000189190.8,ZNF600LUADEAG3.3819e-024.1688e-032.3690e+01image

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3. Enriched editing regions and immune related genes for ZNF600


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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4. Enriched editing regions and immune related splicing for ZNF600


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000189190.8,ZNF600
ESCAEAGIRENSG00000172493.16chr487131792:87132408:87134473:871346940.32513.9349e-029.4829e-050.4019imageNACIN1;ADAR;BUD13;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;IGF2BP1;IGF2BP2;ILF3;KHDRBS1;KHSRP;LIN28B;LSM11;NONO;NOP56;NOP58;PRPF8;PTBP1;RBFOX2;RBM22;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDF1AFF1Macrophages_M2GSVA_HALLMARK_SPERMATOGENESIS

More results



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5. Enriched editing regions and immune infiltration for ZNF600


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000189190.8,ZNF600BLCAEAGT_cells_CD4_naive2.3546e-020.1706image
ENSG00000189190.8,ZNF600BRCAEAGNK_cells_activated4.6915e-020.0811image
ENSG00000189190.8,ZNF600CESCEAGB_cells_naive1.2732e-02-0.2347image
ENSG00000189190.8,ZNF600COADEAGEosinophils2.3466e-070.6948image
chr19:52764259-52765036:-ESCAEERB_cells_naive2.9740e-02-0.3046image
chr19:52783482-52785437:-ESCAEERMast_cells_resting2.8750e-020.3192image
ENSG00000189190.8,ZNF600HNSCEAGDendritic_cells_resting2.6870e-020.1767image
ENSG00000189190.8,ZNF600KIRCEAGEosinophils1.1112e-020.2493image
ENSG00000189190.8,ZNF600KIRPEAGNK_cells_resting1.4903e-040.6763image
ENSG00000189190.8,ZNF600LGGEAGDendritic_cells_activated3.3240e-040.5451image
ENSG00000189190.8,ZNF600LUADEAGT_cells_gamma_delta3.7332e-020.1348image
ENSG00000189190.8,ZNF600LUSCEAGEosinophils3.3922e-040.2842image
ENSG00000189190.8,ZNF600MESOEAGT_cells_follicular_helper2.0517e-020.4356image
chr19:52764259-52765036:-OVEEREosinophils2.3879e-020.2173image
chr19:52783482-52785437:-OVEERDendritic_cells_activated1.2271e-020.4751image
ENSG00000189190.8,ZNF600OVEAGDendritic_cells_resting1.3597e-02-0.1705image
ENSG00000189190.8,ZNF600PAADEAGT_cells_follicular_helper3.3375e-020.2706image
ENSG00000189190.8,ZNF600SARCEAGB_cells_naive3.8639e-02-0.2823image
ENSG00000189190.8,ZNF600SKCMEAGT_cells_CD4_memory_activated2.6051e-020.2660image
chr19:52764259-52765036:-STADEERT_cells_gamma_delta9.9342e-030.2406image
chr19:52783482-52785437:-STADEERNK_cells_resting4.5435e-030.2981image
ENSG00000189190.8,ZNF600STADEAGT_cells_gamma_delta4.9457e-020.1257image
ENSG00000189190.8,ZNF600TGCTEAGMacrophages_M23.2964e-03-0.2842image
ENSG00000189190.8,ZNF600THCAEAGNeutrophils7.2276e-060.4339image
ENSG00000189190.8,ZNF600THYMEAGMacrophages_M01.5847e-020.4230image
ENSG00000189190.8,ZNF600UCECEAGT_cells_regulatory_(Tregs)1.6723e-020.2893image


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6. Enriched editing regions and immune gene sets for ZNF600


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000189190.8,ZNF600BLCAGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG6.0299e-04-0.2561image
ENSG00000189190.8,ZNF600BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.2967e-040.1390image
ENSG00000189190.8,ZNF600CESCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG4.5392e-02-0.1895image
ENSG00000189190.8,ZNF600COADGSVA_HALLMARK_ADIPOGENESISEAG4.3624e-06-0.6371image
ENSG00000189190.8,ZNF600ESCAGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG9.4678e-03-0.2380image
chr19:52764259-52765036:-ESCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER4.6011e-030.3906image
ENSG00000189190.8,ZNF600HNSCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.4507e-02-0.1948image
ENSG00000189190.8,ZNF600KIRCGSVA_HALLMARK_APOPTOSISEAG4.9782e-04-0.3371image
ENSG00000189190.8,ZNF600KIRPGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG1.8245e-03-0.5818image
ENSG00000189190.8,ZNF600LGGGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.7853e-020.3774image
ENSG00000189190.8,ZNF600LIHCGSVA_HALLMARK_COAGULATIONEAG1.2248e-040.3491image
ENSG00000189190.8,ZNF600LUADGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.2116e-02-0.1621image
ENSG00000189190.8,ZNF600LUSCGSVA_HALLMARK_SPERMATOGENESISEAG3.6687e-030.2320image
ENSG00000189190.8,ZNF600MESOGSVA_HALLMARK_E2F_TARGETSEAG3.7743e-02-0.3945image
ENSG00000189190.8,ZNF600OVGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.4995e-03-0.2183image
chr19:52764259-52765036:-OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.9856e-02-0.2091image
ENSG00000189190.8,ZNF600PRADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG1.0609e-03-0.3274image
ENSG00000189190.8,ZNF600SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.4789e-020.2879image
ENSG00000189190.8,ZNF600SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.9837e-030.3146image
chr19:52764259-52765036:-STADGSVA_HALLMARK_APOPTOSISEER1.9953e-020.2177image
ENSG00000189190.8,ZNF600STADGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.9612e-03-0.1790image
chr19:52783482-52785437:-STADGSVA_HALLMARK_HYPOXIAEER9.3748e-040.3448image
ENSG00000189190.8,ZNF600TGCTGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.7361e-04-0.3585image
ENSG00000189190.8,ZNF600THCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.6567e-02-0.2403image
ENSG00000189190.8,ZNF600THYMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG9.1168e-030.4536image
ENSG00000189190.8,ZNF600UCECGSVA_HALLMARK_PROTEIN_SECRETIONEAG7.5390e-03-0.3214image


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7. Enriched editing regions and drugs for ZNF600


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000189190.8,ZNF600BLCAABT.263EAG9.1656e-03-0.1959image
ENSG00000189190.8,ZNF600BRCADasatinibEAG1.6483e-02-0.0981image
ENSG00000189190.8,ZNF600CESCMidostaurinEAG3.8158e-020.1962image
ENSG00000189190.8,ZNF600COADCCT007093EAG3.1234e-07-0.6897image
chr19:52783482-52785437:-ESCAAxitinibEER4.9460e-02-0.2882image
chr19:52764259-52765036:-ESCAAZD7762EER3.1529e-04-0.4845image
ENSG00000189190.8,ZNF600HNSCBIBW2992EAG2.0643e-04-0.2920image
ENSG00000189190.8,ZNF600KIRCKU.55933EAG7.7036e-050.3795image
ENSG00000189190.8,ZNF600KIRPFH535EAG2.0729e-020.4511image
ENSG00000189190.8,ZNF600LGGBMS.708163EAG2.1775e-02-0.3664image
ENSG00000189190.8,ZNF600LIHCGDC0941EAG1.2014e-03-0.2971image
ENSG00000189190.8,ZNF600LUADCCT007093EAG1.9229e-030.1997image
ENSG00000189190.8,ZNF600LUSCLapatinibEAG1.5315e-030.2532image
ENSG00000189190.8,ZNF600MESOErlotinibEAG6.9430e-03-0.4984image
ENSG00000189190.8,ZNF600OVEmbelinEAG2.0282e-030.2123image
chr19:52764259-52765036:-OVBMS.754807EER1.1101e-02-0.2435image
chr19:52783482-52785437:-OVBIBW2992EER2.1189e-02-0.4414image
ENSG00000189190.8,ZNF600PAADBleomycinEAG7.8377e-030.3347image
ENSG00000189190.8,ZNF600PRADBMS.708163EAG5.5775e-050.3974image
ENSG00000189190.8,ZNF600SARCCisplatinEAG1.7798e-03-0.4155image
ENSG00000189190.8,ZNF600SKCMAKT.inhibitor.VIIIEAG7.7798e-03-0.3179image
chr19:52764259-52765036:-STADBortezomibEER1.1461e-02-0.2360image
ENSG00000189190.8,ZNF600STADBAY.61.3606EAG1.6159e-020.1535image
ENSG00000189190.8,ZNF600TGCTIPA.3EAG5.2905e-04-0.3325image
ENSG00000189190.8,ZNF600THCAEmbelinEAG5.2580e-080.5141image
ENSG00000189190.8,ZNF600THYMAZD6244EAG2.8640e-08-0.8046image
ENSG00000189190.8,ZNF600UCECGW.441756EAG2.2912e-040.4326image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType