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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ADSL (ImmuneEditome ID:158)

1. Gene summary of enriched editing regions for ADSL

check button Gene summary
Gene informationGene symbol

ADSL

Gene ID

158

GeneSynonymsAMPS|ASASE|ASL
GeneCytomap

22q13.1

GeneTypeprotein-coding
GeneDescriptionadenylosuccinate lyase|adenylosuccinase
GeneModificationdate20230329
UniprotIDA0A096LP92;P30566;B4DEP1;A0A096LP72;X5D8S6;A0A7P0T8E4;A0A7P0Z472;A0A096LNY4;A0A096LPA2;A0A7P0T9A7;A0A0A6YY92;A0A1B0GWJ0;A0A096LNY5;A0A1B0GTG9;A0A1B0GTJ7;A0A096LNY6;A0A1B0GWF8
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr22:40354700-40355292:+ENST00000477111.2ENSG00000239900.10ADSLncRNA_intronicAluSx1,AluSz,L1M5chr22:40354700-40355292:+.alignment
chr22:40356436-40356771:+ENST00000477111.2ENSG00000239900.10ADSLncRNA_intronicAluJr,AluSgchr22:40356436-40356771:+.alignment
chr22:40367151-40367447:+ENST00000623063.2ENSG00000239900.10ADSLUTR3AluSx1,L2achr22:40367151-40367447:+.alignment
chr22:40368702-40368933:+ENST00000623063.2ENSG00000239900.10ADSLUTR3AluSx1chr22:40368702-40368933:+.alignment


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2. Tumor-specific enriched editing regions for ADSL


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr22:40367151-40367447:+HNSCEER2.6860e-039.3264e-036.9689e+03image

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3. Enriched editing regions and immune related genes for ADSL


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for ADSL


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for ADSL


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000239900.10,ADSLBLCAEAGPlasma_cells6.0757e-030.3319image
ENSG00000239900.10,ADSLCESCEAGT_cells_CD4_naive4.2850e-030.4224image
ENSG00000239900.10,ADSLCOADEAGT_cells_CD4_memory_activated2.2334e-02-0.4462image
chr22:40367151-40367447:+ESCAEERDendritic_cells_activated2.6369e-020.3274image
chr22:40368702-40368933:+ESCAEEREosinophils5.1926e-030.5866image
ENSG00000239900.10,ADSLESCAEAGDendritic_cells_activated1.1145e-020.2878image
chr22:40367151-40367447:+HNSCEERB_cells_naive4.8793e-04-0.6353image
ENSG00000239900.10,ADSLHNSCEAGDendritic_cells_resting1.8456e-020.2771image
ENSG00000239900.10,ADSLKIRCEAGT_cells_regulatory_(Tregs)2.2568e-020.3901image
ENSG00000239900.10,ADSLKIRPEAGMacrophages_M23.4249e-020.3538image
ENSG00000239900.10,ADSLLAMLEAGMast_cells_activated2.1888e-050.7212image
ENSG00000239900.10,ADSLLGGEAGMast_cells_resting7.8581e-030.1954image
ENSG00000239900.10,ADSLLIHCEAGDendritic_cells_activated1.0007e-030.4601image
ENSG00000239900.10,ADSLLUADEAGNK_cells_resting2.5035e-020.2416image
chr22:40368702-40368933:+LUSCEERPlasma_cells5.0831e-03-0.2945image
ENSG00000239900.10,ADSLLUSCEAGNK_cells_activated8.4415e-030.2050image
ENSG00000239900.10,ADSLOVEAGB_cells_naive3.9236e-030.2647image
ENSG00000239900.10,ADSLPRADEAGNK_cells_resting1.8876e-020.2310image
ENSG00000239900.10,ADSLSARCEAGEosinophils4.1212e-020.3954image
chr22:40367151-40367447:+SKCMEERPlasma_cells3.0124e-030.2731image
ENSG00000239900.10,ADSLSKCMEAGPlasma_cells4.1939e-030.2037image
chr22:40354700-40355292:+STADEERT_cells_CD4_memory_resting3.5065e-02-0.3475image
chr22:40367151-40367447:+STADEERDendritic_cells_resting1.6159e-020.2602image
ENSG00000239900.10,ADSLSTADEAGT_cells_CD4_memory_activated2.2024e-030.2594image
ENSG00000239900.10,ADSLTGCTEAGMonocytes1.0249e-020.3188image
ENSG00000239900.10,ADSLTHCAEAGT_cells_CD4_memory_resting1.4925e-020.3689image
ENSG00000239900.10,ADSLUCECEAGDendritic_cells_activated2.6751e-030.3665image


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6. Enriched editing regions and immune gene sets for ADSL


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr22:40368702-40368933:+GBMEER1.7014e-020.43963.9430e-020.38451.0853e-020.46591.7897e-020.4366image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr22:40368702-40368933:+BLCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.8906e-030.4209image
ENSG00000239900.10,ADSLBLCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.5057e-020.2457image
ENSG00000239900.10,ADSLBRCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.3384e-02-0.1643image
ENSG00000239900.10,ADSLCESCGSVA_HALLMARK_COAGULATIONEAG3.0894e-030.4360image
ENSG00000239900.10,ADSLCOADGSVA_HALLMARK_UV_RESPONSE_UPEAG2.6468e-03-0.5648image
chr22:40368702-40368933:+GBMGSVA_HALLMARK_HYPOXIAEER1.7897e-020.4366image
chr22:40367151-40367447:+HNSCGSVA_HALLMARK_HYPOXIAEER4.5425e-030.5385image
ENSG00000239900.10,ADSLHNSCGSVA_HALLMARK_NOTCH_SIGNALINGEAG4.5935e-020.2360image
ENSG00000239900.10,ADSLKIRCGSVA_HALLMARK_UV_RESPONSE_DNEAG3.3108e-02-0.3663image
ENSG00000239900.10,ADSLLGGGSVA_HALLMARK_UV_RESPONSE_DNEAG2.5452e-03-0.2212image
chr22:40368702-40368933:+LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.7911e-020.2204image
ENSG00000239900.10,ADSLOVGSVA_HALLMARK_MYC_TARGETS_V1EAG4.8628e-020.1827image
ENSG00000239900.10,ADSLPRADGSVA_HALLMARK_KRAS_SIGNALING_DNEAG6.9266e-03-0.2645image
ENSG00000239900.10,ADSLSARCGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.2452e-02-0.3932image
ENSG00000239900.10,ADSLSKCMGSVA_HALLMARK_COMPLEMENTEAG9.0401e-030.1860image
chr22:40367151-40367447:+SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.6627e-050.3687image
chr22:40354700-40355292:+STADGSVA_HALLMARK_UV_RESPONSE_DNEER1.3605e-02-0.4022image
chr22:40367151-40367447:+STADGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER1.0967e-040.4072image
ENSG00000239900.10,ADSLSTADGSVA_HALLMARK_P53_PATHWAYEAG7.7718e-050.3310image
chr22:40368702-40368933:+TGCTGSVA_HALLMARK_MYC_TARGETS_V1EER3.4595e-02-0.4081image
ENSG00000239900.10,ADSLTHCAGSVA_HALLMARK_ANGIOGENESISEAG1.4668e-030.4702image
ENSG00000239900.10,ADSLUCECGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.6031e-02-0.2977image
ENSG00000239900.10,ADSLUCSGSVA_HALLMARK_MYOGENESISEAG2.0928e-02-0.4130image


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7. Enriched editing regions and drugs for ADSL


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr22:40368702-40368933:+BLCAGefitinibEER1.6987e-04-0.5167image
ENSG00000239900.10,ADSLBLCABosutinibEAG5.2873e-03-0.3370image
ENSG00000239900.10,ADSLCESCAMG.706EAG4.6931e-040.5105image
ENSG00000239900.10,ADSLCOADKIN001.135EAG3.0654e-03-0.5578image
chr22:40367151-40367447:+ESCABMS.536924EER1.0791e-020.3725image
ENSG00000239900.10,ADSLESCAGW.441756EAG1.4525e-03-0.3567image
ENSG00000239900.10,ADSLGBMCyclopamineEAG2.0733e-02-0.2842image
chr22:40367151-40367447:+HNSCBAY.61.3606EER1.8413e-030.5813image
ENSG00000239900.10,ADSLHNSCEHT.1864EAG5.8184e-030.3220image
ENSG00000239900.10,ADSLKIRCAP.24534EAG3.5173e-020.3624image
ENSG00000239900.10,ADSLLAMLEmbelinEAG4.9589e-030.5247image
ENSG00000239900.10,ADSLLGGGSK269962AEAG1.8644e-03-0.2285image
ENSG00000239900.10,ADSLLUADBMS.708163EAG1.6872e-020.2571image
chr22:40367151-40367447:+LUADBleomycinEER1.4482e-02-0.4282image
ENSG00000239900.10,ADSLOVImatinibEAG7.7352e-030.2451image
ENSG00000239900.10,ADSLPRADBX.795EAG1.5625e-020.2377image
ENSG00000239900.10,ADSLSARCBryostatin.1EAG6.2390e-03-0.5128image
ENSG00000239900.10,ADSLSKCMAG.014699EAG1.2559e-030.2288image
chr22:40367151-40367447:+SKCMCGP.60474EER8.4951e-03-0.2433image
chr22:40354700-40355292:+STADCisplatinEER4.1784e-03-0.4600image
chr22:40367151-40367447:+STADEHT.1864EER7.2313e-040.3597image
ENSG00000239900.10,ADSLSTADAZD6244EAG4.8398e-04-0.2942image
ENSG00000239900.10,ADSLTGCTLapatinibEAG4.4842e-02-0.2517image
chr22:40368702-40368933:+TGCTAZD6482EER2.2068e-03-0.5635image
ENSG00000239900.10,ADSLTHCAAS601245EAG1.1324e-02-0.3827image
ENSG00000239900.10,ADSLUCSMetforminEAG5.0591e-03-0.4908image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType