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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: KCTD7 (ImmuneEditome ID:154881)

1. Gene summary of enriched editing regions for KCTD7

check button Gene summary
Gene informationGene symbol

KCTD7

Gene ID

154881

GeneSynonymsCLN14|EPM3
GeneCytomap

7q11.21

GeneTypeprotein-coding
GeneDescriptionBTB/POZ domain-containing protein KCTD7|potassium channel tetramerisation domain containing 7
GeneModificationdate20230518
UniprotIDQ96MP8;A0A024RDN7;A0A1W2PS30;A0A1W2PP71;A0A1X7SBW1;A0A1W2PQL2
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr7:66670563-66671299:+ENST00000503687.1ENSG00000243335.7KCTD7intronicAluSz,(AC)n,FAM,AluJr,(TATATA)nchr7:66670563-66671299:+.alignment
chr7:66674210-66675399:+ENST00000503687.1ENSG00000243335.7KCTD7intronicMIR,AluSx1,AluSq10,(TA)n,L1ME3chr7:66674210-66675399:+.alignment
chr7:66680923-66681577:+ENST00000503687.1ENSG00000243335.7KCTD7intronicMIRb,AluSx1,AluJrchr7:66680923-66681577:+.alignment
chr7:66683723-66692055:+ENST00000503687.1ENSG00000243335.7KCTD7intronicA-rich,L1ME2,MER47A,AluY,AluSp,(AAACA)n,(TTAT)n,MLT1B,AluSz6,AluJo,AluSx,AluSg7,FRAM,AluJr,AluSc,AluJb,AluJr4,L1M4c,AluSz,AluSg,AluSq2chr7:66683723-66692055:+.alignment
chr7:66695184-66696659:+ENST00000503687.1ENSG00000243335.7KCTD7intronicAluSx1,L2c,AluYk11,AluSz,AluJrchr7:66695184-66696659:+.alignment
chr7:66701195-66701748:+ENST00000503687.1ENSG00000243335.7KCTD7intronicAluJo,AluSq2chr7:66701195-66701748:+.alignment
chr7:66703005-66703282:+ENST00000503687.1ENSG00000243335.7KCTD7intronicL1MB5,AluYchr7:66703005-66703282:+.alignment
chr7:66714637-66717829:+ENST00000503687.1ENSG00000243335.7KCTD7intronicFAM,L1MD2,L1M5,AluSz6,AluSx,AluJr,AluJb,AluY,(TCC)nchr7:66714637-66717829:+.alignment
chr7:66721017-66721991:+ENST00000503687.1ENSG00000243335.7KCTD7intronicL1M4,AluSz,AluJr,MLT1Dchr7:66721017-66721991:+.alignment
chr7:66726428-66726798:+ENST00000503687.1ENSG00000243335.7KCTD7intronicAluJr,L1MB8,AluSzchr7:66726428-66726798:+.alignment
chr7:66738516-66739632:+ENST00000503687.1ENSG00000243335.7KCTD7intronicLTR54,AluJb,L2a,MIRb,AluSx1,AluSpchr7:66738516-66739632:+.alignment
chr7:66741834-66745912:+ENST00000503687.1ENSG00000243335.7KCTD7intronicL2c,AluY,AluJb,AluJr,FRAM,FLAM_C,AluSz6,AluSg,AluSx4chr7:66741834-66745912:+.alignment


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2. Tumor-specific enriched editing regions for KCTD7


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000243335.7,KCTD7BRCAEAG4.2894e-02image
chr7:66714637-66717829:+KIRPEER1.2445e-02image
ENSG00000243335.7,KCTD7KIRPEAG6.0718e-03image
chr7:66714637-66717829:+THCAEER3.8195e-02image
ENSG00000243335.7,KCTD7THCAEAG3.3074e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr7:66714637-66717829:+ESCACliEER3.3526e-021.2673e-02-0.3815image
chr7:66683723-66692055:+STADPathEER2.7303e-021.4763e-020.1525image
chr7:66680923-66681577:+STADPathEER1.2377e-032.7261e-030.5954image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for KCTD7


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr7:66714637-66717829:+PRADEERENSG00000153317,ASAP10.45581.2104e-181.8875e-180.4042imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr7:66714637-66717829:+PRADEERENSG00000010404,IDS0.44775.8837e-186.3380e-190.4094imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr7:66714637-66717829:+UCECEERENSG00000163125,RPRD20.54111.8274e-063.6636e-070.4270imageNNNAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE
chr7:66714637-66717829:+UCECEERENSG00000160710,ADAR0.52138.0065e-068.6922e-080.4470imageNNADARDendritic_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr7:66714637-66717829:+UCECEERENSG00000116580,GON4L0.51908.3765e-061.4190e-070.4403imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr7:66714637-66717829:+UCECEERENSG00000186063,AIDA0.51521.1988e-051.2096e-090.4999imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr7:66714637-66717829:+UCECEERENSG00000149806,FAU-0.49993.1245e-051.6663e-06-0.4044imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr7:66714637-66717829:+UCECEERENSG00000116539,ASH1L0.49623.7061e-056.4672e-070.4187imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr7:66714637-66717829:+UCECEERENSG00000118217,ATF60.49053.9479e-056.1282e-090.4809imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr7:66714637-66717829:+UCECEERENSG00000263001,GTF2I0.49563.9644e-051.4061e-060.4070imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE

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4. Enriched editing regions and immune related splicing for KCTD7


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000243335.7,KCTD7
DLBCEAGIRENSG00000114942.9chr2206159584:206159684:206159958:2061600590.80054.0042e-029.6236e-040.5269imageNACIN1;AUH;CELF2;CNBP;CSTF2T;DDX3X;DDX42;DGCR8;DICER1;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;LARP4B;LARP7;LIN28B;MBNL2;MOV10;MSI1;NOP56;NOP58;PRPF8;PTBP1;RBFOX2;RBM10;RBM27;SF3B4;SLBP;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TNRC6A;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1NANeutrophilsGSVA_HALLMARK_SPERMATOGENESIS
chr7:66683723-66692055:+
OVEERIRENSG00000125089.12chr48232407:8233513:8235432:82355550.21003.6091e-023.9065e-140.5237imageNADAR;CELF2;EIF4A3;ELAVL1;FUS;IGF2BP2;PTBP1;RBFOX2;TARDBP;U2AF2NA
ENSG00000243335.7,KCTD7
TGCTEAGESENSG00000133110.10chr1337571368:37571458:37574571:37574652:37577752:375777970.28621.8728e-021.7670e-040.4199imageNDKC1;ELAVL1;EWSR1;FBL;FUS;HNRNPL;IGF2BP2;NOP58;SRSF10;TAF15POSTNMacrophages_M2GSVA_HALLMARK_HEDGEHOG_SIGNALING
ENSG00000243335.7,KCTD7
TGCTEAGMEXENSG00000133110.10chr1337569743:37569821:37570579:37570667:37574571:37574652:37577752:37577798-0.30323.3046e-023.7933e-05-0.4035imageNDKC1;ELAVL1;EWSR1;FBL;FUS;HNRNPL;IGF2BP2;NOP58;SRSF10;TAF15POSTNMacrophages_M2GSVA_HALLMARK_HEDGEHOG_SIGNALING
ENSG00000243335.7,KCTD7
THYMEAGA5ENSG00000101361.10chr202656400:2656549:2655933:2656034:2655933:26562140.36842.5909e-024.2624e-050.4050imageNACIN1;ADAR;AUH;CELF2;CNBP;CSTF2T;DDX3X;DDX42;DGCR8;DICER1;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;LARP4B;LARP7;LIN28B;MBNL2;MOV10;MSI1;NOP56;NOP58;PRPF8;PTBP1;QKI;RBFOX2;RBM10;RBM27;RBM47;SF3B4;SLBP;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TNRC6A;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1NAMast_cells_restingGSVA_HALLMARK_E2F_TARGETS
chr7:66714637-66717829:+
THYMEERIRENSG00000100412.11chr2241526261:41527420:41527900:415280220.60814.5712e-064.6095e-080.5404imageNNNANK_cells_activatedGSVA_HALLMARK_TGF_BETA_SIGNALING
chr7:66714637-66717829:+
THYMEERIRENSG00000076662.5chr1910333775:10334408:10334527:103347230.58222.1195e-052.6141e-070.5138imageNNICAM3Mast_cells_restingGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr7:66714637-66717829:+
THYMEERMEXENSG00000171298.8chr1780111982:80112100:80112577:80112711:80113217:80113366:80116967:801170820.53573.4714e-043.4297e-080.5473imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr7:66714637-66717829:+
THYMEERMEXENSG00000106400.7chr7101218180:101218217:101218318:101218435:101221616:101221796:101222603:1012227740.40322.1235e-029.1054e-050.4028imageNNNAMacrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION
chr7:66714637-66717829:+
THYMEERA3ENSG00000150787.3chr11112228593:112228673:112230625:112230682:112230207:112230682-0.37962.5300e-021.1894e-05-0.4482imageNNNAMacrophages_M1GSVA_HALLMARK_ANGIOGENESIS

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5. Enriched editing regions and immune infiltration for KCTD7


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000243335.7,KCTD7ACCEAGMast_cells_activated2.6296e-020.3808image
chr7:66683723-66692055:+BLCAEERMacrophages_M01.6353e-03-0.2344image
chr7:66714637-66717829:+BLCAEERT_cells_CD81.2150e-020.1559image
ENSG00000243335.7,KCTD7BLCAEAGT_cells_regulatory_(Tregs)4.4407e-020.1143image
chr7:66683723-66692055:+BRCAEERMast_cells_resting1.1981e-040.1955image
chr7:66714637-66717829:+BRCAEERT_cells_CD4_memory_resting1.1458e-030.1341image
ENSG00000243335.7,KCTD7BRCAEAGT_cells_CD4_memory_resting2.5072e-040.1347image
ENSG00000243335.7,KCTD7CHOLEAGMonocytes1.1618e-020.5520image
ENSG00000243335.7,KCTD7COADEAGMast_cells_activated2.2834e-020.1916image
ENSG00000243335.7,KCTD7DLBCEAGDendritic_cells_activated2.8790e-030.4825image
chr7:66683723-66692055:+ESCAEERNK_cells_activated4.1421e-020.1714image
chr7:66695184-66696659:+ESCAEERNK_cells_resting1.9840e-02-0.2779image
chr7:66701195-66701748:+ESCAEERMast_cells_activated3.3501e-020.3656image
chr7:66703005-66703282:+ESCAEERMacrophages_M23.5591e-020.4607image
ENSG00000243335.7,KCTD7ESCAEAGMacrophages_M13.2530e-020.1686image
chr7:66714637-66717829:+GBMEERMacrophages_M11.2923e-020.1999image
ENSG00000243335.7,KCTD7GBMEAGMacrophages_M12.6816e-030.2373image
chr7:66714637-66717829:+HNSCEERMacrophages_M11.2871e-030.1986image
ENSG00000243335.7,KCTD7HNSCEAGMacrophages_M11.9728e-040.2116image
chr7:66714637-66717829:+KICHEERNK_cells_activated2.2645e-02-0.3790image
chr7:66714637-66717829:+KIRCEERNK_cells_activated2.4599e-02-0.2035image
chr7:66683723-66692055:+KIRPEERMast_cells_resting2.6503e-020.2219image
chr7:66714637-66717829:+KIRPEERT_cells_CD83.3115e-03-0.2033image
ENSG00000243335.7,KCTD7KIRPEAGT_cells_CD83.4792e-04-0.2364image
chr7:66683723-66692055:+LAMLEERB_cells_naive2.3183e-020.2089image
chr7:66695184-66696659:+LAMLEERT_cells_follicular_helper4.3811e-030.5309image
chr7:66741834-66745912:+LAMLEERNK_cells_resting1.8876e-020.2310image
ENSG00000243335.7,KCTD7LAMLEAGMonocytes5.9936e-03-0.2264image
chr7:66714637-66717829:+LGGEERNeutrophils1.6765e-020.1106image
ENSG00000243335.7,KCTD7LGGEAGT_cells_CD4_naive1.7217e-030.1412image
chr7:66714637-66717829:+LIHCEERNeutrophils6.0913e-030.3270image
ENSG00000243335.7,KCTD7LIHCEAGT_cells_CD4_memory_activated3.2742e-020.1727image
chr7:66683723-66692055:+LUADEERT_cells_follicular_helper3.5534e-02-0.1551image
chr7:66714637-66717829:+LUADEERMast_cells_resting1.2390e-050.2593image
ENSG00000243335.7,KCTD7LUADEAGMast_cells_resting1.9777e-070.2783image
chr7:66670563-66671299:+LUSCEERB_cells_memory7.8138e-030.3959image
chr7:66683723-66692055:+LUSCEERMast_cells_resting2.8460e-03-0.1938image
chr7:66714637-66717829:+LUSCEERMonocytes7.0769e-03-0.1598image
ENSG00000243335.7,KCTD7LUSCEAGMonocytes3.3764e-02-0.1084image
ENSG00000243335.7,KCTD7MESOEAGMacrophages_M09.7305e-03-0.3588image
chr7:66683723-66692055:+OVEERMacrophages_M24.2505e-02-0.1405image
chr7:66695184-66696659:+OVEERMast_cells_activated7.3843e-040.4342image
chr7:66701195-66701748:+OVEERT_cells_regulatory_(Tregs)4.3931e-030.5604image
chr7:66714637-66717829:+OVEERNeutrophils4.0859e-020.1225image
chr7:66741834-66745912:+OVEERT_cells_regulatory_(Tregs)1.3404e-020.2453image
ENSG00000243335.7,KCTD7PAADEAGMacrophages_M13.7270e-030.2744image
chr7:66683723-66692055:+PCPGEERMacrophages_M01.3952e-030.3233image
chr7:66683723-66692055:+PRADEERT_cells_CD83.3718e-020.1843image
chr7:66714637-66717829:+PRADEERT_cells_CD4_memory_resting2.8595e-050.1996image
ENSG00000243335.7,KCTD7PRADEAGT_cells_CD4_memory_resting7.2988e-040.1599image
chr7:66683723-66692055:+SARCEERB_cells_naive2.6442e-030.3565image
chr7:66714637-66717829:+SARCEERT_cells_CD4_memory_resting3.3154e-030.2360image
ENSG00000243335.7,KCTD7SARCEAGMast_cells_resting3.4696e-030.2168image
chr7:66670563-66671299:+SKCMEERB_cells_memory1.9585e-02-0.3032image
chr7:66683723-66692055:+SKCMEERB_cells_memory1.9345e-02-0.1548image
chr7:66714637-66717829:+SKCMEERT_cells_CD82.7760e-030.1745image
ENSG00000243335.7,KCTD7SKCMEAGMacrophages_M01.6741e-02-0.1235image
chr7:66680923-66681577:+STADEERT_cells_regulatory_(Tregs)2.4958e-020.4662image
chr7:66683723-66692055:+STADEERNK_cells_resting5.8193e-03-0.1684image
chr7:66695184-66696659:+STADEERB_cells_memory2.2083e-020.2181image
chr7:66701195-66701748:+STADEERMacrophages_M15.7944e-030.3848image
ENSG00000243335.7,KCTD7STADEAGT_cells_CD4_naive2.4982e-02-0.1227image
chr7:66714637-66717829:+THCAEERNK_cells_activated5.4350e-04-0.1669image
ENSG00000243335.7,KCTD7THCAEAGNK_cells_activated1.0560e-04-0.1808image
chr7:66714637-66717829:+THYMEERNK_cells_activated4.8273e-040.3624image
ENSG00000243335.7,KCTD7THYMEAGNK_cells_activated1.1877e-040.3828image
chr7:66683723-66692055:+UCECEERT_cells_CD4_memory_resting1.6386e-020.2860image
chr7:66714637-66717829:+UCECEERMast_cells_activated1.0288e-020.2235image
ENSG00000243335.7,KCTD7UCECEAGNK_cells_activated2.2017e-02-0.1875image
chr7:66714637-66717829:+UCSEERMast_cells_activated3.8796e-030.4266image
ENSG00000243335.7,KCTD7UVMEAGT_cells_gamma_delta4.5955e-02-0.4201image


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6. Enriched editing regions and immune gene sets for KCTD7


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr7:66683723-66692055:+BRCAEER3.0861e-13-0.36151.2356e-06-0.24522.1464e-11-0.33385.9256e-04-0.1750image
ENSG00000243335.7,KCTD7LUADEAG5.9886e-05-0.21652.9747e-03-0.16111.2362e-04-0.20731.6209e-02-0.1307image
chr7:66741834-66745912:+STADEER2.3989e-040.27431.2595e-020.18836.4031e-040.25561.4169e-060.3552image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000243335.7,KCTD7ACCGSVA_HALLMARK_NOTCH_SIGNALINGEAG4.3784e-02-0.3479image
chr7:66683723-66692055:+BLCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER8.0001e-04-0.2491image
chr7:66714637-66717829:+BLCAGSVA_HALLMARK_MITOTIC_SPINDLEEER2.2593e-030.1893image
ENSG00000243335.7,KCTD7BRCAGSVA_HALLMARK_MYC_TARGETS_V2EAG4.9961e-07-0.1841image
chr7:66683723-66692055:+BRCAGSVA_HALLMARK_MYC_TARGETS_V2EER5.6770e-10-0.3103image
chr7:66714637-66717829:+BRCAGSVA_HALLMARK_MYC_TARGETS_V2EER8.1180e-04-0.1381image
chr7:66670563-66671299:+BRCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER3.7130e-050.4079image
ENSG00000243335.7,KCTD7CESCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.2571e-03-0.2227image
chr7:66714637-66717829:+CESCGSVA_HALLMARK_PROTEIN_SECRETIONEER1.3632e-040.2852image
ENSG00000243335.7,KCTD7COADGSVA_HALLMARK_MYC_TARGETS_V2EAG5.4051e-03-0.2331image
ENSG00000243335.7,KCTD7DLBCGSVA_HALLMARK_ADIPOGENESISEAG1.5483e-02-0.4006image
chr7:66683723-66692055:+ESCAGSVA_HALLMARK_FATTY_ACID_METABOLISMEER6.4256e-05-0.3289image
chr7:66703005-66703282:+ESCAGSVA_HALLMARK_MYC_TARGETS_V2EER1.0235e-02-0.5473image
chr7:66701195-66701748:+ESCAGSVA_HALLMARK_HEME_METABOLISMEER4.2474e-020.3499image
chr7:66741834-66745912:+ESCAGSVA_HALLMARK_HEME_METABOLISMEER1.2502e-020.2465image
ENSG00000243335.7,KCTD7ESCAGSVA_HALLMARK_MYOGENESISEAG3.0244e-030.2323image
chr7:66714637-66717829:+GBMGSVA_HALLMARK_ANDROGEN_RESPONSEEER6.3404e-040.2723image
ENSG00000243335.7,KCTD7GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.5365e-030.2197image
chr7:66714637-66717829:+HNSCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER4.7124e-040.2153image
ENSG00000243335.7,KCTD7HNSCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG3.4953e-050.2346image
ENSG00000243335.7,KCTD7KICHGSVA_HALLMARK_HEME_METABOLISMEAG2.6304e-020.3556image
chr7:66714637-66717829:+KICHGSVA_HALLMARK_NOTCH_SIGNALINGEER1.9939e-020.3864image
ENSG00000243335.7,KCTD7KIRCGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.2304e-020.1471image
ENSG00000243335.7,KCTD7KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEAG6.5497e-040.2255image
chr7:66714637-66717829:+KIRPGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER1.8459e-030.2152image
chr7:66683723-66692055:+KIRPGSVA_HALLMARK_P53_PATHWAYEER9.8913e-06-0.4261image
ENSG00000243335.7,KCTD7LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.5129e-02-0.1853image
ENSG00000243335.7,KCTD7LGGGSVA_HALLMARK_DNA_REPAIREAG1.3564e-07-0.2354image
chr7:66714637-66717829:+LGGGSVA_HALLMARK_DNA_REPAIREER5.0377e-06-0.2094image
ENSG00000243335.7,KCTD7LIHCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG4.3664e-03-0.2292image
chr7:66714637-66717829:+LIHCGSVA_HALLMARK_MITOTIC_SPINDLEEER1.1221e-030.3841image
ENSG00000243335.7,KCTD7LUADGSVA_HALLMARK_MTORC1_SIGNALINGEAG2.6106e-04-0.1974image
chr7:66714637-66717829:+LUADGSVA_HALLMARK_SPERMATOGENESISEER1.0783e-02-0.1530image
chr7:66683723-66692055:+LUADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.2810e-03-0.2236image
chr7:66670563-66671299:+LUSCGSVA_HALLMARK_MYC_TARGETS_V2EER1.2444e-02-0.3738image
chr7:66683723-66692055:+LUSCGSVA_HALLMARK_MITOTIC_SPINDLEEER6.8563e-04-0.2199image
ENSG00000243335.7,KCTD7LUSCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG9.5260e-06-0.2238image
chr7:66714637-66717829:+LUSCGSVA_HALLMARK_ADIPOGENESISEER4.1675e-04-0.2084image
ENSG00000243335.7,KCTD7MESOGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG7.2686e-04-0.4580image
ENSG00000243335.7,KCTD7OVGSVA_HALLMARK_HEME_METABOLISMEAG7.9814e-040.1976image
chr7:66695184-66696659:+OVGSVA_HALLMARK_GLYCOLYSISEER7.2504e-030.3520image
chr7:66701195-66701748:+OVGSVA_HALLMARK_BILE_ACID_METABOLISMEER3.3196e-02-0.4360image
chr7:66714637-66717829:+OVGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER4.2349e-040.2096image
chr7:66683723-66692055:+OVGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.2702e-03-0.2215image
ENSG00000243335.7,KCTD7PAADGSVA_HALLMARK_MITOTIC_SPINDLEEAG7.6949e-030.2529image
chr7:66683723-66692055:+PCPGGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.8858e-02-0.2406image
chr7:66714637-66717829:+PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEER2.8796e-030.3814image
ENSG00000243335.7,KCTD7PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEAG6.9880e-030.2471image
chr7:66683723-66692055:+PRADGSVA_HALLMARK_GLYCOLYSISEER7.8095e-05-0.3357image
ENSG00000243335.7,KCTD7PRADGSVA_HALLMARK_UV_RESPONSE_DNEAG1.9226e-130.3399image
chr7:66714637-66717829:+PRADGSVA_HALLMARK_UV_RESPONSE_DNEER9.5632e-150.3606image
chr7:66714637-66717829:+SARCGSVA_HALLMARK_DNA_REPAIREER1.2710e-04-0.3049image
ENSG00000243335.7,KCTD7SARCGSVA_HALLMARK_DNA_REPAIREAG1.1480e-05-0.3206image
chr7:66683723-66692055:+SARCGSVA_HALLMARK_GLYCOLYSISEER3.5986e-03-0.3459image
chr7:66670563-66671299:+SKCMGSVA_HALLMARK_APOPTOSISEER2.6190e-020.2894image
chr7:66714637-66717829:+SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.0112e-040.2100image
ENSG00000243335.7,KCTD7SKCMGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG4.8793e-04-0.1792image
chr7:66683723-66692055:+SKCMGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.1946e-04-0.2520image
ENSG00000243335.7,KCTD7STADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.6214e-050.2335image
chr7:66738516-66739632:+STADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER9.1854e-030.4402image
chr7:66701195-66701748:+STADGSVA_HALLMARK_NOTCH_SIGNALINGEER6.3290e-030.3811image
chr7:66714637-66717829:+STADGSVA_HALLMARK_APICAL_SURFACEEER1.0914e-030.2087image
chr7:66695184-66696659:+STADGSVA_HALLMARK_APICAL_SURFACEEER6.4659e-030.2582image
chr7:66741834-66745912:+STADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER3.7005e-070.3730image
chr7:66683723-66692055:+STADGSVA_HALLMARK_PEROXISOMEEER5.4472e-03-0.1696image
chr7:66674210-66675399:+STADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.4689e-030.6381image
chr7:66714637-66717829:+TGCTGSVA_HALLMARK_PROTEIN_SECRETIONEER2.9065e-020.2972image
ENSG00000243335.7,KCTD7TGCTGSVA_HALLMARK_UV_RESPONSE_DNEAG1.4408e-020.2317image
ENSG00000243335.7,KCTD7THCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.2357e-070.2448image
chr7:66714637-66717829:+THCAGSVA_HALLMARK_MITOTIC_SPINDLEEER8.3994e-090.2745image
chr7:66714637-66717829:+THYMGSVA_HALLMARK_PROTEIN_SECRETIONEER1.4022e-080.5574image
ENSG00000243335.7,KCTD7THYMGSVA_HALLMARK_UV_RESPONSE_DNEAG3.8276e-090.5568image
ENSG00000243335.7,KCTD7UCECGSVA_HALLMARK_UV_RESPONSE_DNEAG7.3399e-040.2736image
chr7:66714637-66717829:+UCECGSVA_HALLMARK_PROTEIN_SECRETIONEER1.1550e-040.3305image
chr7:66683723-66692055:+UCECGSVA_HALLMARK_DNA_REPAIREER1.1635e-03-0.3803image
ENSG00000243335.7,KCTD7UCSGSVA_HALLMARK_ANDROGEN_RESPONSEEAG3.0911e-050.5683image
chr7:66714637-66717829:+UCSGSVA_HALLMARK_TGF_BETA_SIGNALINGEER1.0688e-030.4768image


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7. Enriched editing regions and drugs for KCTD7


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000243335.7,KCTD7ACCCytarabineEAG7.4938e-030.4506image
chr7:66714637-66717829:+ACCAZD8055EER4.9472e-020.3681image
ENSG00000243335.7,KCTD7BLCACEP.701EAG2.8426e-030.1690image
chr7:66714637-66717829:+BLCAElesclomolEER1.5152e-040.2337image
chr7:66683723-66692055:+BLCAGNF.2EER1.2466e-040.2836image
chr7:66670563-66671299:+BRCACCT007093EER9.9372e-04-0.3308image
ENSG00000243335.7,KCTD7BRCACCT007093EAG1.1090e-12-0.2584image
chr7:66714637-66717829:+BRCACCT007093EER2.9099e-08-0.2268image
chr7:66683723-66692055:+BRCACCT007093EER7.6645e-14-0.3700image
chr7:66714637-66717829:+CESCBMS.536924EER1.3065e-070.3882image
ENSG00000243335.7,KCTD7CESCBMS.536924EAG1.0444e-060.3333image
ENSG00000243335.7,KCTD7CHOLCCT007093EAG4.7615e-02-0.4480image
ENSG00000243335.7,KCTD7COADBMS.708163EAG5.5543e-05-0.3327image
ENSG00000243335.7,KCTD7DLBCGW843682XEAG3.3657e-020.3549image
chr7:66695184-66696659:+ESCACI.1040EER4.8033e-020.2372image
chr7:66683723-66692055:+ESCAGDC.0449EER3.1361e-02-0.1814image
chr7:66741834-66745912:+ESCAAZD6482EER4.9875e-02-0.1947image
chr7:66701195-66701748:+ESCALapatinibEER1.0370e-02-0.4401image
ENSG00000243335.7,KCTD7ESCAKIN001.135EAG1.0272e-02-0.2018image
chr7:66703005-66703282:+ESCACCT007093EER2.6667e-03-0.6209image
chr7:66714637-66717829:+GBMCytarabineEER1.3048e-030.2568image
ENSG00000243335.7,KCTD7GBMCytarabineEAG7.0929e-040.2666image
chr7:66714637-66717829:+HNSCDMOGEER3.4262e-04-0.2204image
ENSG00000243335.7,KCTD7HNSCBAY.61.3606EAG4.5335e-04-0.1996image
ENSG00000243335.7,KCTD7KICHLenalidomideEAG1.6023e-020.3833image
chr7:66714637-66717829:+KIRCAKT.inhibitor.VIIIEER5.4910e-03-0.2500image
chr7:66683723-66692055:+KIRCKIN001.135EER2.6245e-040.3540image
ENSG00000243335.7,KCTD7KIRCAKT.inhibitor.VIIIEAG1.0164e-04-0.2775image
ENSG00000243335.7,KCTD7KIRPBAY.61.3606EAG1.1048e-04-0.2549image
chr7:66683723-66692055:+KIRPAS601245EER4.4928e-030.2819image
chr7:66714637-66717829:+KIRPAZD6244EER9.7898e-050.2674image
ENSG00000243335.7,KCTD7LAMLGSK269962AEAG1.1039e-08-0.4511image
chr7:66741834-66745912:+LAMLBI.2536EER1.9314e-02-0.2302image
chr7:66695184-66696659:+LAMLKIN001.135EER3.5672e-02-0.4059image
chr7:66683723-66692055:+LAMLCamptothecinEER4.0811e-020.1886image
chr7:66714637-66717829:+LGGGW843682XEER4.9925e-090.2664image
ENSG00000243335.7,KCTD7LGGGW843682XEAG7.3973e-100.2735image
ENSG00000243335.7,KCTD7LIHCCMKEAG1.5028e-020.1963image
chr7:66714637-66717829:+LIHCCI.1040EER4.0037e-030.3422image
chr7:66714637-66717829:+LUADGSK269962AEER1.4207e-040.2270image
chr7:66683723-66692055:+LUADEmbelinEER6.2344e-03-0.2009image
ENSG00000243335.7,KCTD7LUADGSK269962AEAG2.0149e-040.2012image
chr7:66714637-66717829:+LUSCBAY.61.3606EER2.7083e-05-0.2467image
chr7:66683723-66692055:+LUSCAZD.2281EER5.8243e-03-0.1798image
ENSG00000243335.7,KCTD7LUSCMethotrexateEAG2.9761e-08-0.2792image
ENSG00000243335.7,KCTD7MESOCCT007093EAG5.8816e-05-0.5320image
chr7:66695184-66696659:+OVAZD.0530EER3.0294e-030.3859image
chr7:66714637-66717829:+OVEmbelinEER2.0742e-03-0.1836image
chr7:66683723-66692055:+OVGSK.650394EER3.7889e-03-0.1995image
ENSG00000243335.7,KCTD7OVBAY.61.3606EAG4.3225e-03-0.1686image
chr7:66741834-66745912:+OVABT.263EER8.0172e-030.2624image
ENSG00000243335.7,KCTD7PAADATRAEAG1.1496e-04-0.3595image
chr7:66683723-66692055:+PCPGEmbelinEER3.3218e-03-0.2983image
chr7:66714637-66717829:+PCPGGDC.0449EER4.4864e-030.3649image
ENSG00000243335.7,KCTD7PCPGEmbelinEAG1.4930e-02-0.2236image
chr7:66683723-66692055:+PRADCCT007093EER9.4223e-03-0.2244image
ENSG00000243335.7,KCTD7PRADCCT007093EAG2.7970e-09-0.2776image
chr7:66714637-66717829:+PRADCCT007093EER7.8502e-12-0.3210image
ENSG00000243335.7,KCTD7READCCT007093EAG4.1323e-02-0.2712image
chr7:66714637-66717829:+SARCBMS.509744EER7.5747e-070.3873image
chr7:66683723-66692055:+SARCCCT007093EER7.7354e-05-0.4575image
ENSG00000243335.7,KCTD7SARCDMOGEAG9.7612e-06-0.3230image
chr7:66683723-66692055:+SKCMBMS.754807EER4.4065e-03-0.1879image
chr7:66714637-66717829:+SKCMATRAEER2.5595e-04-0.2124image
chr7:66670563-66671299:+SKCMGW843682XEER2.0750e-020.3005image
ENSG00000243335.7,KCTD7SKCMATRAEAG6.3894e-05-0.2052image
chr7:66714637-66717829:+STADCyclopamineEER1.7220e-03-0.2009image
chr7:66683723-66692055:+STADGDC0941EER1.0956e-03-0.1987image
ENSG00000243335.7,KCTD7STADAZ628EAG4.8416e-05-0.2204image
chr7:66738516-66739632:+STADCCT018159EER4.6393e-020.3440image
chr7:66741834-66745912:+STADBMS.509744EER4.4590e-03-0.2140image
chr7:66695184-66696659:+STADEHT.1864EER4.1946e-03-0.2710image
chr7:66674210-66675399:+STADCCT007093EER3.7869e-020.4671image
chr7:66680923-66681577:+STADAZD7762EER3.7541e-02-0.4360image
ENSG00000243335.7,KCTD7TGCTAZD6482EAG1.5367e-02-0.2296image
chr7:66714637-66717829:+TGCTDMOGEER3.0062e-03-0.3964image
chr7:66714637-66717829:+THCAAICAREER2.1640e-10-0.3013image
ENSG00000243335.7,KCTD7THCABAY.61.3606EAG3.3683e-07-0.2364image
ENSG00000243335.7,KCTD7THYMAKT.inhibitor.VIIIEAG7.7747e-13-0.6500image
chr7:66714637-66717829:+THYMAKT.inhibitor.VIIIEER4.4948e-12-0.6520image
ENSG00000243335.7,KCTD7UCECAZD6482EAG2.8137e-03-0.2431image
chr7:66714637-66717829:+UCECBMS.536924EER6.5608e-060.3824image
chr7:66683723-66692055:+UCECGefitinibEER5.0377e-03-0.3316image
chr7:66714637-66717829:+UCSMidostaurinEER1.3495e-02-0.3698image
ENSG00000243335.7,KCTD7UCSBicalutamideEAG2.9012e-03-0.4250image
ENSG00000243335.7,KCTD7UVMBAY.61.3606EAG1.7800e-02-0.4893image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType