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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: CYB5A (ImmuneEditome ID:1528)

1. Gene summary of enriched editing regions for CYB5A

check button Gene summary
Gene informationGene symbol

CYB5A

Gene ID

1528

GeneSynonymsCYB5|MCB5|METAG
GeneCytomap

18q22.3

GeneTypeprotein-coding
GeneDescriptioncytochrome b5|cytochrome b5 type A (microsomal)|epididymis secretory sperm binding protein|type 1 cyt-b5
GeneModificationdate20230329
UniprotIDP00167;J3KNC7
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr18:74250898-74251137:-ENST00000340533.7ENSG00000166347.17CYB5AUTR3AluSxchr18:74250898-74251137:-.alignment
chr18:74252694-74254744:-ENST00000299438.12ENSG00000166347.17CYB5Aexonic(A)n,AluSx1,AluY,AluSq2chr18:74252694-74254744:-.alignment
chr18:74252694-74254744:-ENST00000340533.7ENSG00000166347.17CYB5Aexonic(A)n,AluSx1,AluY,AluSq2chr18:74252694-74254744:-.alignment
chr18:74252694-74254744:-ENST00000397914.4ENSG00000166347.17CYB5Aexonic(A)n,AluSx1,AluY,AluSq2chr18:74252694-74254744:-.alignment


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2. Tumor-specific enriched editing regions for CYB5A


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr18:74252694-74254744:-KIRCEER3.2714e-04image
ENSG00000166347.17,CYB5AKIRCEAG9.6042e-06image
ENSG00000166347.17,CYB5ALIHCEAG6.4801e-06image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for CYB5A


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for CYB5A


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for CYB5A


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr18:74250898-74251137:-BLCAEERDendritic_cells_resting4.5328e-02-0.3033image
chr18:74250898-74251137:-BRCAEERMacrophages_M03.1586e-020.2162image
ENSG00000166347.17,CYB5ABRCAEAGT_cells_CD4_memory_resting2.7955e-02-0.1914image
chr18:74252694-74254744:-KIRCEERT_cells_regulatory_(Tregs)3.4624e-03-0.2270image
ENSG00000166347.17,CYB5AKIRPEAGNK_cells_activated3.9595e-02-0.3842image
chr18:74252694-74254744:-LIHCEERMast_cells_resting3.9849e-020.2348image
ENSG00000166347.17,CYB5ALIHCEAGMacrophages_M11.3899e-02-0.1759image
chr18:74250898-74251137:-LUADEERT_cells_CD4_memory_activated6.8539e-030.3250image
ENSG00000166347.17,CYB5ALUADEAGMacrophages_M26.5590e-03-0.2862image


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6. Enriched editing regions and immune gene sets for CYB5A


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
ENSG00000166347.17,CYB5ALIHCEAG3.5978e-03image3.7543e-020.1491image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr18:74250898-74251137:-LUADEER1.4619e-030.37843.5281e-030.34911.5850e-030.37594.4935e-050.4737image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr18:74250898-74251137:-BLCAGSVA_HALLMARK_UV_RESPONSE_DNEER6.6723e-030.4031image
ENSG00000166347.17,CYB5ABLCAGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG7.5480e-030.3534image
chr18:74250898-74251137:-BRCAGSVA_HALLMARK_ANGIOGENESISEER3.4529e-030.2912image
ENSG00000166347.17,CYB5ABRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.2751e-020.2163image
ENSG00000166347.17,CYB5AKIRCGSVA_HALLMARK_APICAL_SURFACEEAG2.4112e-070.3299image
chr18:74252694-74254744:-KIRCGSVA_HALLMARK_ANDROGEN_RESPONSEEER6.0370e-070.3780image
ENSG00000166347.17,CYB5AKIRPGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG3.7960e-020.3872image
ENSG00000166347.17,CYB5ALIHCGSVA_HALLMARK_ANGIOGENESISEAG2.1748e-020.1643image
chr18:74252694-74254744:-LIHCGSVA_HALLMARK_PROTEIN_SECRETIONEER1.2898e-020.2822image
ENSG00000166347.17,CYB5ALUADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG3.1860e-050.4258image
chr18:74250898-74251137:-LUADGSVA_HALLMARK_APOPTOSISEER4.2974e-050.4748image


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7. Enriched editing regions and drugs for CYB5A


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000166347.17,CYB5ABLCACyclopamineEAG9.2569e-03-0.3448image
chr18:74250898-74251137:-BRCAMidostaurinEER8.8681e-03-0.2618image
ENSG00000166347.17,CYB5ABRCACisplatinEAG1.2940e-02-0.2158image
ENSG00000166347.17,CYB5AKIRCLapatinibEAG4.5361e-06-0.2946image
chr18:74252694-74254744:-KIRCLapatinibEER5.3876e-08-0.4090image
ENSG00000166347.17,CYB5AKIRPAG.014699EAG1.2470e-020.4580image
ENSG00000166347.17,CYB5ALIHCAMG.706EAG1.0493e-02-0.1829image
chr18:74252694-74254744:-LIHCCCT007093EER9.9288e-03-0.2922image
ENSG00000166347.17,CYB5ALUADAZD.0530EAG4.1048e-05-0.4204image
chr18:74250898-74251137:-LUADAUY922EER2.3108e-04-0.4324image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType
chr18:74250898-74251137:-ENST00000340533.7P00167DB11136ChromiumSmallMoleculeDrug
chr18:74250898-74251137:-ENST00000340533.7P00167DB14527Chromic nitrateSmallMoleculeDrug
chr18:74250898-74251137:-ENST00000340533.7P00167DB14528Chromium gluconateSmallMoleculeDrug
chr18:74250898-74251137:-ENST00000340533.7P00167DB14529Chromium nicotinateSmallMoleculeDrug
chr18:74250898-74251137:-ENST00000340533.7P00167DB14530Chromous sulfateSmallMoleculeDrug
chr18:74252694-74254744:-ENST00000340533.7P00167DB11136ChromiumSmallMoleculeDrug
chr18:74252694-74254744:-ENST00000340533.7P00167DB14527Chromic nitrateSmallMoleculeDrug
chr18:74252694-74254744:-ENST00000340533.7P00167DB14528Chromium gluconateSmallMoleculeDrug
chr18:74252694-74254744:-ENST00000340533.7P00167DB14529Chromium nicotinateSmallMoleculeDrug
chr18:74252694-74254744:-ENST00000340533.7P00167DB14530Chromous sulfateSmallMoleculeDrug
chr18:74252694-74254744:-ENST00000397914.4P00167DB11136ChromiumSmallMoleculeDrug
chr18:74252694-74254744:-ENST00000397914.4P00167DB14527Chromic nitrateSmallMoleculeDrug
chr18:74252694-74254744:-ENST00000397914.4P00167DB14528Chromium gluconateSmallMoleculeDrug
chr18:74252694-74254744:-ENST00000397914.4P00167DB14529Chromium nicotinateSmallMoleculeDrug
chr18:74252694-74254744:-ENST00000397914.4P00167DB14530Chromous sulfateSmallMoleculeDrug