CAeditome Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: WDSUB1 (ImmuneEditome ID:151525)

1. Gene summary of enriched editing regions for WDSUB1

check button Gene summary
Gene informationGene symbol

WDSUB1

Gene ID

151525

GeneSynonymsUBOX6|WDSAM1
GeneCytomap

2q24.2

GeneTypeprotein-coding
GeneDescriptionWD repeat, SAM and U-box domain-containing protein 1
GeneModificationdate20230517
UniprotIDD3DPA6;Q8N9V3;B8ZZF2
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr2:159236737-159237352:-ENST00000358147.7ENSG00000196151.9WDSUB1intronicL1MC5a,AluSx1chr2:159236737-159237352:-.alignment
chr2:159236737-159237352:-ENST00000359774.7ENSG00000196151.9WDSUB1intronicL1MC5a,AluSx1chr2:159236737-159237352:-.alignment
chr2:159236737-159237352:-ENST00000392796.6ENSG00000196151.9WDSUB1intronicL1MC5a,AluSx1chr2:159236737-159237352:-.alignment
chr2:159236737-159237352:-ENST00000409124.1ENSG00000196151.9WDSUB1intronicL1MC5a,AluSx1chr2:159236737-159237352:-.alignment
chr2:159236737-159237352:-ENST00000409990.6ENSG00000196151.9WDSUB1intronicL1MC5a,AluSx1chr2:159236737-159237352:-.alignment
chr2:159241461-159242192:-ENST00000358147.7ENSG00000196151.9WDSUB1intronicAluSz6,AluSx3,AluYj4chr2:159241461-159242192:-.alignment
chr2:159241461-159242192:-ENST00000359774.7ENSG00000196151.9WDSUB1intronicAluSz6,AluSx3,AluYj4chr2:159241461-159242192:-.alignment
chr2:159241461-159242192:-ENST00000392796.6ENSG00000196151.9WDSUB1intronicAluSz6,AluSx3,AluYj4chr2:159241461-159242192:-.alignment
chr2:159241461-159242192:-ENST00000409124.1ENSG00000196151.9WDSUB1intronicAluSz6,AluSx3,AluYj4chr2:159241461-159242192:-.alignment
chr2:159241461-159242192:-ENST00000409990.6ENSG00000196151.9WDSUB1intronicAluSz6,AluSx3,AluYj4chr2:159241461-159242192:-.alignment
chr2:159265160-159265648:-ENST00000358147.7ENSG00000196151.9WDSUB1intronic(CA)n,AluJbchr2:159265160-159265648:-.alignment
chr2:159265160-159265648:-ENST00000359774.7ENSG00000196151.9WDSUB1intronic(CA)n,AluJbchr2:159265160-159265648:-.alignment
chr2:159265160-159265648:-ENST00000392796.6ENSG00000196151.9WDSUB1intronic(CA)n,AluJbchr2:159265160-159265648:-.alignment
chr2:159265160-159265648:-ENST00000409124.1ENSG00000196151.9WDSUB1intronic(CA)n,AluJbchr2:159265160-159265648:-.alignment
chr2:159265160-159265648:-ENST00000409990.6ENSG00000196151.9WDSUB1intronic(CA)n,AluJbchr2:159265160-159265648:-.alignment
chr2:159266904-159267600:-ENST00000358147.7ENSG00000196151.9WDSUB1intronicAluJr,AluJochr2:159266904-159267600:-.alignment
chr2:159266904-159267600:-ENST00000359774.7ENSG00000196151.9WDSUB1intronicAluJr,AluJochr2:159266904-159267600:-.alignment
chr2:159266904-159267600:-ENST00000392796.6ENSG00000196151.9WDSUB1intronicAluJr,AluJochr2:159266904-159267600:-.alignment
chr2:159266904-159267600:-ENST00000409124.1ENSG00000196151.9WDSUB1intronicAluJr,AluJochr2:159266904-159267600:-.alignment
chr2:159266904-159267600:-ENST00000409990.6ENSG00000196151.9WDSUB1intronicAluJr,AluJochr2:159266904-159267600:-.alignment


Top

2. Tumor-specific enriched editing regions for WDSUB1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


Top

check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000196151.9,WDSUB1BRCAPathEAG2.4004e-028.2184e-030.2116image


Top

check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr2:159241461-159242192:-ESCAEER2.4201e-023.0416e-023.2002e+01image

Top

3. Enriched editing regions and immune related genes for WDSUB1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



Top

4. Enriched editing regions and immune related splicing for WDSUB1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



Top

5. Enriched editing regions and immune infiltration for WDSUB1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000196151.9,WDSUB1BRCAEAGMacrophages_M13.2710e-020.1722image
chr2:159241461-159242192:-ESCAEERB_cells_naive5.5937e-03-0.3400image
ENSG00000196151.9,WDSUB1ESCAEAGB_cells_naive8.4864e-03-0.2729image
ENSG00000196151.9,WDSUB1KIRCEAGPlasma_cells3.3998e-020.2091image
ENSG00000196151.9,WDSUB1LAMLEAGDendritic_cells_activated3.8973e-020.3363image
ENSG00000196151.9,WDSUB1LGGEAGT_cells_CD4_memory_resting3.4324e-03-0.3526image
ENSG00000196151.9,WDSUB1LUSCEAGB_cells_memory9.3509e-030.4011image
chr2:159241461-159242192:-OVEERT_cells_CD4_memory_activated2.7596e-020.2419image
ENSG00000196151.9,WDSUB1PRADEAGT_cells_follicular_helper8.7944e-030.4555image
ENSG00000196151.9,WDSUB1STADEAGNK_cells_resting7.8603e-030.1928image
ENSG00000196151.9,WDSUB1THCAEAGMacrophages_M21.3927e-02-0.1768image


Top

6. Enriched editing regions and immune gene sets for WDSUB1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


Top

check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000196151.9,WDSUB1STADEAG2.3341e-020.16492.3572e-020.16464.8254e-020.14393.3796e-020.1545image


Top

check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000196151.9,WDSUB1BRCAGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG1.2365e-020.2012image
ENSG00000196151.9,WDSUB1COADGSVA_HALLMARK_UV_RESPONSE_UPEAG2.2949e-020.3949image
ENSG00000196151.9,WDSUB1ESCAGSVA_HALLMARK_NOTCH_SIGNALINGEAG6.5463e-040.3488image
chr2:159241461-159242192:-ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER4.7551e-020.2467image
ENSG00000196151.9,WDSUB1KIRCGSVA_HALLMARK_COAGULATIONEAG4.2372e-030.2796image
ENSG00000196151.9,WDSUB1LAMLGSVA_HALLMARK_G2M_CHECKPOINTEAG3.9876e-020.3349image
ENSG00000196151.9,WDSUB1LGGGSVA_HALLMARK_ANDROGEN_RESPONSEEAG4.8259e-02-0.2422image
ENSG00000196151.9,WDSUB1LUADGSVA_HALLMARK_UV_RESPONSE_UPEAG2.1139e-040.3751image
ENSG00000196151.9,WDSUB1LUSCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG2.1248e-02-0.3588image
ENSG00000196151.9,WDSUB1OVGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.1147e-020.2254image
chr2:159241461-159242192:-OVGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.1290e-020.2768image
ENSG00000196151.9,WDSUB1STADGSVA_HALLMARK_GLYCOLYSISEAG2.0047e-040.2673image
chr2:159241461-159242192:-STADGSVA_HALLMARK_HYPOXIAEER8.6147e-040.2562image
chr2:159266904-159267600:-STADGSVA_HALLMARK_DNA_REPAIREER2.8331e-020.3762image
ENSG00000196151.9,WDSUB1THCAGSVA_HALLMARK_MYC_TARGETS_V1EAG2.7168e-030.2147image
ENSG00000196151.9,WDSUB1THYMGSVA_HALLMARK_GLYCOLYSISEAG5.2441e-030.5737image


Top

7. Enriched editing regions and drugs for WDSUB1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000196151.9,WDSUB1BRCAAZD6482EAG2.5505e-020.1806image
ENSG00000196151.9,WDSUB1COADCGP.60474EAG1.2762e-02-0.4289image
ENSG00000196151.9,WDSUB1ESCABexaroteneEAG2.6030e-03-0.3104image
chr2:159241461-159242192:-ESCABexaroteneEER1.5685e-03-0.3844image
ENSG00000196151.9,WDSUB1KIRCCisplatinEAG9.5509e-03-0.2543image
chr2:159236737-159237352:-KIRCCI.1040EER3.5524e-02-0.2219image
ENSG00000196151.9,WDSUB1LAMLLapatinibEAG4.1041e-060.6705image
ENSG00000196151.9,WDSUB1LUADKU.55933EAG1.7826e-02-0.2452image
ENSG00000196151.9,WDSUB1LUSCCEP.701EAG1.3775e-02-0.3818image
ENSG00000196151.9,WDSUB1OVBX.795EAG5.4052e-030.2464image
chr2:159241461-159242192:-OVBAY.61.3606EER2.5957e-02-0.2444image
ENSG00000196151.9,WDSUB1STADDocetaxelEAG1.2173e-02-0.1820image
chr2:159241461-159242192:-STADAS601245EER2.3039e-03-0.2350image
ENSG00000196151.9,WDSUB1TGCTDocetaxelEAG2.5224e-030.6370image
ENSG00000196151.9,WDSUB1THCACCT007093EAG2.6052e-020.1602image
ENSG00000196151.9,WDSUB1THYMDocetaxelEAG4.6564e-02-0.4286image


Top

check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType