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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: KLHL23 (ImmuneEditome ID:151230)

1. Gene summary of enriched editing regions for KLHL23

check button Gene summary
Gene informationGene symbol

KLHL23

Gene ID

151230

GeneSynonymsDITHP
GeneCytomap

2q31.1

GeneTypeprotein-coding
GeneDescriptionkelch-like protein 23|kelch-like 23
GeneModificationdate20230329
UniprotIDQ8NBE8;H7C0F4;S4R452;S4R3P4
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr2:169702301-169704473:+ENST00000272797.7ENSG00000213160.8KLHL23intronicMLT1E2,MLT1E1A,FLAM_C,AluJb,L1MEg,AluJrchr2:169702301-169704473:+.alignment
chr2:169702301-169704473:+ENST00000498202.5ENSG00000213160.8KLHL23intronicMLT1E2,MLT1E1A,FLAM_C,AluJb,L1MEg,AluJrchr2:169702301-169704473:+.alignment
chr2:169702301-169704473:+ENST00000602521.1ENSG00000213160.8KLHL23intronicMLT1E2,MLT1E1A,FLAM_C,AluJb,L1MEg,AluJrchr2:169702301-169704473:+.alignment
chr2:169709466-169709756:+ENST00000272797.7ENSG00000213160.8KLHL23intronicAluJr,(ATTT)nchr2:169709466-169709756:+.alignment
chr2:169709466-169709756:+ENST00000498202.5ENSG00000213160.8KLHL23intronicAluJr,(ATTT)nchr2:169709466-169709756:+.alignment
chr2:169709466-169709756:+ENST00000602521.1ENSG00000213160.8KLHL23intronicAluJr,(ATTT)nchr2:169709466-169709756:+.alignment
chr2:169744639-169745503:+ENST00000494387.1ENSG00000213160.8KLHL23ncRNA_intronicAluY,AluSx3,AluSz6chr2:169744639-169745503:+.alignment
chr2:169752479-169753012:+ENST00000437875.1ENSG00000213160.8KLHL23intronicAluJr,AluSxchr2:169752479-169753012:+.alignment
chr2:169752479-169753012:+ENST00000448589.1ENSG00000213160.8KLHL23intronicAluJr,AluSxchr2:169752479-169753012:+.alignment
chr2:169754426-169754611:+ENST00000437875.1ENSG00000213160.8KLHL23intronicAluScchr2:169754426-169754611:+.alignment
chr2:169754426-169754611:+ENST00000448589.1ENSG00000213160.8KLHL23intronicAluScchr2:169754426-169754611:+.alignment
chr2:169758524-169759211:+ENST00000437875.1ENSG00000213160.8KLHL23intronicAluJr,AluSx1chr2:169758524-169759211:+.alignment
chr2:169758524-169759211:+ENST00000448589.1ENSG00000213160.8KLHL23intronicAluJr,AluSx1chr2:169758524-169759211:+.alignment


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2. Tumor-specific enriched editing regions for KLHL23


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000213160.8,KLHL23THCAEAG4.3958e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for KLHL23


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for KLHL23


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000213160.8,KLHL23
STADEAGIRENSG00000213676.6chr632119823:32119957:32120770:321209020.32604.7188e-053.1567e-120.4089imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CPSF6;CSTF2T;DDX3X;DDX42;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM22;RBM27;RBM47;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NANK_cells_restingGSVA_HALLMARK_HEME_METABOLISM
ENSG00000213160.8,KLHL23
STADEAGIRENSG00000141452.5chr1823524129:23526765:23527794:235279010.32015.5172e-053.5573e-130.4249imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZNF184NANK_cells_activatedGSVA_HALLMARK_HEME_METABOLISM

More results



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5. Enriched editing regions and immune infiltration for KLHL23


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr2:169709466-169709756:+BLCAEERT_cells_follicular_helper1.8370e-030.6520image
ENSG00000213160.8,KLHL23BLCAEAGNK_cells_activated1.9554e-030.3222image
chr2:169702301-169704473:+BRCAEERPlasma_cells2.6251e-03-0.1214image
chr2:169709466-169709756:+BRCAEERMast_cells_resting5.1174e-04-0.1788image
ENSG00000213160.8,KLHL23BRCAEAGB_cells_naive3.6843e-02-0.0765image
ENSG00000213160.8,KLHL23CESCEAGT_cells_regulatory_(Tregs)2.5954e-020.3030image
chr2:169702301-169704473:+COADEERMacrophages_M11.4381e-030.5179image
ENSG00000213160.8,KLHL23COADEAGMacrophages_M11.9814e-02-0.2480image
chr2:169709466-169709756:+ESCAEERNK_cells_resting3.5959e-02-0.2974image
chr2:169709466-169709756:+GBMEERNK_cells_activated5.9499e-030.4556image
ENSG00000213160.8,KLHL23HNSCEAGDendritic_cells_resting3.6024e-020.3909image
chr2:169702301-169704473:+KIRCEERPlasma_cells9.0237e-030.2884image
chr2:169709466-169709756:+KIRCEERB_cells_memory3.7270e-02-0.3264image
ENSG00000213160.8,KLHL23KIRCEAGNK_cells_activated3.9660e-020.1628image
chr2:169702301-169704473:+LAMLEERT_cells_CD82.9946e-020.2399image
ENSG00000213160.8,KLHL23LAMLEAGT_cells_CD84.7734e-020.2141image
chr2:169702301-169704473:+LGGEERPlasma_cells1.3737e-020.2421image
chr2:169709466-169709756:+LGGEERMast_cells_activated2.5049e-020.1900image
ENSG00000213160.8,KLHL23LIHCEAGMacrophages_M12.1361e-02-0.2494image
chr2:169709466-169709756:+LUADEERT_cells_CD4_memory_resting2.6511e-03-0.4992image
ENSG00000213160.8,KLHL23LUADEAGT_cells_CD4_memory_activated4.1036e-020.1500image
chr2:169702301-169704473:+LUSCEERB_cells_memory1.2370e-020.4306image
ENSG00000213160.8,KLHL23LUSCEAGDendritic_cells_resting6.0770e-03-0.2359image
chr2:169702301-169704473:+OVEERNeutrophils1.0381e-020.1938image
ENSG00000213160.8,KLHL23OVEAGT_cells_CD82.6364e-020.1443image
chr2:169702301-169704473:+PCPGEERT_cells_CD4_memory_resting4.0667e-02-0.3172image
ENSG00000213160.8,KLHL23PCPGEAGT_cells_CD83.4480e-020.2445image
chr2:169702301-169704473:+PRADEERB_cells_naive5.1098e-030.1657image
chr2:169709466-169709756:+PRADEERMacrophages_M13.4600e-030.2464image
ENSG00000213160.8,KLHL23PRADEAGT_cells_CD89.7969e-03-0.1367image
ENSG00000213160.8,KLHL23READEAGMast_cells_resting4.2993e-020.3491image
chr2:169702301-169704473:+STADEEREosinophils6.2664e-050.2778image
chr2:169709466-169709756:+STADEERT_cells_CD4_memory_resting3.5831e-03-0.3968image
chr2:169752479-169753012:+STADEERDendritic_cells_resting2.0863e-020.3197image
chr2:169754426-169754611:+STADEERT_cells_CD4_naive1.4943e-02-0.3181image
ENSG00000213160.8,KLHL23STADEAGMonocytes5.2385e-030.1701image
ENSG00000213160.8,KLHL23THYMEAGMacrophages_M07.3857e-030.3859image
chr2:169702301-169704473:+UCECEERMacrophages_M04.3812e-020.4239image
ENSG00000213160.8,KLHL23UCSEAGB_cells_memory2.4905e-030.6116image


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6. Enriched editing regions and immune gene sets for KLHL23


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000213160.8,KLHL23SKCMEAG6.1887e-04-0.55011.9431e-05-0.65529.7523e-03-0.43104.4316e-02-0.3420image
ENSG00000213160.8,KLHL23STADEAG1.5775e-04-0.22881.7570e-03-0.19021.4053e-03-0.19413.5608e-05-0.2497image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000213160.8,KLHL23BLCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG8.9879e-03-0.2739image
chr2:169709466-169709756:+BLCAGSVA_HALLMARK_FATTY_ACID_METABOLISMEER2.8318e-020.4899image
chr2:169709466-169709756:+BRCAGSVA_HALLMARK_COMPLEMENTEER4.9700e-040.1792image
chr2:169702301-169704473:+BRCAGSVA_HALLMARK_MTORC1_SIGNALINGEER5.7536e-050.1619image
ENSG00000213160.8,KLHL23BRCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.4597e-030.1108image
ENSG00000213160.8,KLHL23CESCGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.6552e-03-0.4010image
chr2:169702301-169704473:+COADGSVA_HALLMARK_UV_RESPONSE_DNEER4.4253e-030.4696image
ENSG00000213160.8,KLHL23COADGSVA_HALLMARK_UV_RESPONSE_UPEAG4.0745e-04-0.3688image
chr2:169702301-169704473:+ESCAGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER1.2471e-040.3743image
ENSG00000213160.8,KLHL23GBMGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG7.7247e-03-0.2822image
ENSG00000213160.8,KLHL23HNSCGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.1285e-02-0.4637image
chr2:169702301-169704473:+KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.7848e-020.2626image
chr2:169709466-169709756:+KIRCGSVA_HALLMARK_P53_PATHWAYEER4.7295e-020.3117image
ENSG00000213160.8,KLHL23KIRCGSVA_HALLMARK_KRAS_SIGNALING_UPEAG3.5823e-05-0.3206image
ENSG00000213160.8,KLHL23LAMLGSVA_HALLMARK_PROTEIN_SECRETIONEAG5.5572e-03-0.2966image
chr2:169702301-169704473:+LAMLGSVA_HALLMARK_PROTEIN_SECRETIONEER7.0251e-03-0.2955image
chr2:169709466-169709756:+LGGGSVA_HALLMARK_APICAL_SURFACEEER2.7396e-020.1871image
ENSG00000213160.8,KLHL23LGGGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.0298e-06-0.2352image
ENSG00000213160.8,KLHL23LIHCGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.6276e-04-0.3861image
ENSG00000213160.8,KLHL23LUADGSVA_HALLMARK_PEROXISOMEEAG6.7756e-03-0.1979image
chr2:169709466-169709756:+LUADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.6265e-030.4853image
ENSG00000213160.8,KLHL23LUSCGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.3034e-02-0.2140image
chr2:169702301-169704473:+LUSCGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER1.5340e-020.4186image
chr2:169702301-169704473:+OVGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER1.2300e-050.3248image
chr2:169709466-169709756:+OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.9704e-020.2603image
ENSG00000213160.8,KLHL23PAADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG3.7352e-03-0.4282image
chr2:169702301-169704473:+PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEER4.1801e-020.3155image
ENSG00000213160.8,KLHL23PCPGGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG1.2490e-02-0.2872image
chr2:169702301-169704473:+PRADGSVA_HALLMARK_HEME_METABOLISMEER1.0647e-060.2848image
ENSG00000213160.8,KLHL23PRADGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.3004e-020.1315image
ENSG00000213160.8,KLHL23READGSVA_HALLMARK_COMPLEMENTEAG7.9829e-03-0.4474image
ENSG00000213160.8,KLHL23SARCGSVA_HALLMARK_APICAL_JUNCTIONEAG6.9079e-03-0.3370image
ENSG00000213160.8,KLHL23SKCMGSVA_HALLMARK_E2F_TARGETSEAG8.3352e-05-0.6154image
chr2:169758524-169759211:+STADGSVA_HALLMARK_COAGULATIONEER2.3731e-020.4697image
chr2:169754426-169754611:+STADGSVA_HALLMARK_APICAL_SURFACEEER1.4780e-020.3186image
ENSG00000213160.8,KLHL23STADGSVA_HALLMARK_GLYCOLYSISEAG1.8186e-07-0.3121image
chr2:169752479-169753012:+STADGSVA_HALLMARK_SPERMATOGENESISEER5.7893e-04-0.4612image
chr2:169702301-169704473:+STADGSVA_HALLMARK_UV_RESPONSE_UPEER3.9376e-020.1451image
ENSG00000213160.8,KLHL23THYMGSVA_HALLMARK_HEME_METABOLISMEAG9.5700e-04-0.4662image
ENSG00000213160.8,KLHL23UCECGSVA_HALLMARK_MYOGENESISEAG6.2673e-030.3357image
chr2:169702301-169704473:+UCECGSVA_HALLMARK_MYOGENESISEER4.3095e-020.4252image


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7. Enriched editing regions and drugs for KLHL23


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr2:169709466-169709756:+BLCAFH535EER2.8512e-020.4894image
ENSG00000213160.8,KLHL23BLCAAKT.inhibitor.VIIIEAG3.4216e-030.3054image
chr2:169702301-169704473:+BRCAImatinibEER9.4954e-03-0.1048image
ENSG00000213160.8,KLHL23BRCABI.2536EAG8.3733e-030.0965image
chr2:169709466-169709756:+BRCACamptothecinEER3.1720e-04-0.1852image
ENSG00000213160.8,KLHL23CESCDasatinibEAG5.7693e-04-0.4613image
chr2:169702301-169704473:+COADKIN001.135EER6.1901e-03-0.4537image
ENSG00000213160.8,KLHL23COADBI.D1870EAG5.4049e-030.2942image
chr2:169702301-169704473:+ESCAAICAREER3.6723e-03-0.2879image
ENSG00000213160.8,KLHL23GBMAS601245EAG3.8913e-020.2206image
chr2:169709466-169709756:+GBMEHT.1864EER1.3471e-020.4138image
ENSG00000213160.8,KLHL23KIRCBexaroteneEAG4.0743e-030.2259image
chr2:169702301-169704473:+KIRCKU.55933EER1.9346e-02-0.2594image
ENSG00000213160.8,KLHL23KIRPGSK.650394EAG2.7108e-030.3967image
chr2:169702301-169704473:+KIRPGSK.650394EER7.3981e-030.4224image
ENSG00000213160.8,KLHL23LAMLBicalutamideEAG2.8932e-02-0.2357image
chr2:169702301-169704473:+LAMLGW843682XEER6.1024e-03-0.3004image
chr2:169702301-169704473:+LGGGW.441756EER3.4336e-03-0.2858image
ENSG00000213160.8,KLHL23LGGAMG.706EAG3.7962e-04-0.1771image
chr2:169709466-169709756:+LGGBMS.536924EER4.9122e-03-0.2373image
ENSG00000213160.8,KLHL23LIHCMG.132EAG5.2540e-03-0.3111image
ENSG00000213160.8,KLHL23LUADATRAEAG2.1844e-02-0.1681image
chr2:169709466-169709756:+LUADAZD7762EER5.1381e-03-0.4690image
chr2:169702301-169704473:+LUSCJNJ.26854165EER7.3881e-03-0.4578image
ENSG00000213160.8,KLHL23LUSCGW843682XEAG1.4040e-040.3231image
chr2:169702301-169704473:+OVCI.1040EER4.3552e-03-0.2152image
ENSG00000213160.8,KLHL23OVBMS.536924EAG8.0989e-04-0.2161image
ENSG00000213160.8,KLHL23PAADDasatinibEAG1.0807e-020.3806image
chr2:169702301-169704473:+PCPGAxitinibEER9.2343e-030.3970image
ENSG00000213160.8,KLHL23PCPGJNK.Inhibitor.VIIIEAG7.8289e-03-0.3048image
ENSG00000213160.8,KLHL23PRADAZD6482EAG4.2268e-04-0.1861image
chr2:169702301-169704473:+PRADAZD6482EER5.6525e-06-0.2661image
ENSG00000213160.8,KLHL23READCGP.082996EAG2.6416e-030.4994image
ENSG00000213160.8,KLHL23SKCMGSK269962AEAG2.9051e-040.5764image
chr2:169752479-169753012:+STADEtoposideEER2.6216e-030.4088image
chr2:169709466-169709756:+STADA.443654EER8.3491e-03-0.3621image
chr2:169754426-169754611:+STADLenalidomideEER1.9177e-020.3068image
chr2:169702301-169704473:+STADMidostaurinEER3.6063e-040.2486image
chr2:169744639-169745503:+STADCI.1040EER2.1139e-030.5234image
ENSG00000213160.8,KLHL23STADAMG.706EAG6.9748e-05-0.2405image
chr2:169702301-169704473:+THCABMS.708163EER1.1534e-02-0.2595image
ENSG00000213160.8,KLHL23THYMBosutinibEAG1.4980e-04-0.5253image
ENSG00000213160.8,KLHL23UCECCGP.60474EAG2.7735e-04-0.4366image
chr2:169702301-169704473:+UCECCHIR.99021EER4.2691e-02-0.4260image
ENSG00000213160.8,KLHL23UCSGW.441756EAG3.4649e-02-0.4521image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType