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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: TRIM69 (ImmuneEditome ID:140691)

1. Gene summary of enriched editing regions for TRIM69

check button Gene summary
Gene informationGene symbol

TRIM69

Gene ID

140691

GeneSynonymsHSD-34|HSD34|RNF36|Trif
GeneCytomap

15q21.1

GeneTypeprotein-coding
GeneDescriptionE3 ubiquitin-protein ligase TRIM69|RFP-like domain-containing protein trimless|RING-type E3 ubiquitin transferase TRIM69|ring finger protein 36
GeneModificationdate20230329
UniprotIDQ86WT6;A0A0G2JPI4;H0YL66;H0YKB8
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr15:44733037-44735168:+ENST00000560141.2ENSG00000185880.11TRIM69ncRNA_exonicMLT2C1,AluSz,FLAM_C,AluJb,AluY,MLT1J,L2c,MER49chr15:44733037-44735168:+.alignment


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2. Tumor-specific enriched editing regions for TRIM69


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr15:44733037-44735168:+HNSCEER1.8514e-05image
ENSG00000185880.11,TRIM69HNSCEAG1.8992e-05image
chr15:44733037-44735168:+LUADEER2.2379e-03image
ENSG00000185880.11,TRIM69LUADEAG2.2154e-03image
chr15:44733037-44735168:+LUSCEER8.2639e-05image
ENSG00000185880.11,TRIM69LUSCEAG6.7107e-05image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for TRIM69


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr15:44733037-44735168:+KICHEERENSG00000273179,RP11-20I20.4-0.59741.7174e-022.1656e-05-0.5041imageNNNAGSVA_HALLMARK_SPERMATOGENESIS
chr15:44733037-44735168:+KICHEERENSG00000149091,DGKZ-0.58181.8562e-022.5150e-05-0.5007imageNBCCIP;CSTF2T;DDX42;DGCR8;DHX9;EIF4A3;ELAVL1;FAM120A;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;NONO;NOP56;NOP58;PTBP1;RBFOX2;SLTM;U2AF1;U2AF2;UPF1DGKZGSVA_HALLMARK_SPERMATOGENESIS
chr15:44733037-44735168:+KICHEERENSG00000172531,PPP1CA-0.57782.0732e-023.9187e-07-0.5847imageNBCCIP;CSTF2T;DDX42;DGCR8;EIF4A3;ELAVL1;FAM120A;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;NONO;NOP56;NOP58;PTBP1;RBFOX2;SLTM;U2AF1;U2AF2;UPF1PPP1CAMacrophages_M2GSVA_HALLMARK_SPERMATOGENESIS
chr15:44733037-44735168:+KICHEERENSG00000136819,C9orf780.55482.3602e-021.3292e-050.5151imageNCSTF2T;DDX42;DGCR8;EIF4A3;ELAVL1;FAM120A;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;NONO;NOP56;NOP58;PTBP1;RBFOX2;SLTM;U2AF1;U2AF2;UPF1NANK_cells_activatedGSVA_HALLMARK_DNA_REPAIR
chr15:44733037-44735168:+KICHEERENSG00000180806,HOXC9-0.54472.6978e-025.9131e-05-0.4803imageNCSTF2T;DGCR8;DHX9;EIF4A3;ELAVL1;HNRNPC;HNRNPK;HNRNPM;NOP56;NOP58;PTBP1;RBFOX2;SLTM;U2AF1;U2AF2;UPF1NAGSVA_HALLMARK_SPERMATOGENESIS
chr15:44733037-44735168:+KICHEERENSG00000175634,RPS6KB2-0.53692.7403e-027.9629e-05-0.4728imageNBCCIP;CSTF2T;DDX42;DGCR8;DHX9;EIF4A3;ELAVL1;FAM120A;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;NONO;NOP56;NOP58;PTBP1;RBFOX2;SLTM;U2AF1;U2AF2;UPF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_FATTY_ACID_METABOLISM
chr15:44733037-44735168:+KICHEERENSG00000100300,TSPO-0.55172.9215e-021.3516e-06-0.5620imageNCSTF2T;DDX42;DGCR8;EIF4A3;ELAVL1;FAM120A;HNRNPC;HNRNPM;NOP56;PTBP1;RBFOX2;SLTM;U2AF1;U2AF2;UPF1TSPOT_cells_CD8GSVA_HALLMARK_SPERMATOGENESIS
chr15:44733037-44735168:+KICHEERENSG00000105131,EPHX3-0.54952.9215e-024.9297e-05-0.4847imageNDGCR8;DHX9;EIF4A3;ELAVL1;HNRNPC;NOP56;NOP58;U2AF1;U2AF2NAGSVA_HALLMARK_APICAL_SURFACE
chr15:44733037-44735168:+KICHEERENSG00000172830,SSH3-0.54592.9448e-028.7646e-06-0.5242imageNBCCIP;CSTF2T;DGCR8;EIF4A3;FAM120A;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;NONO;NOP56;NOP58;PTBP1;RBFOX2;SLTM;U2AF1;U2AF2;UPF1NAGSVA_HALLMARK_APICAL_SURFACE
chr15:44733037-44735168:+KICHEERENSG00000064547,LPAR2-0.54202.9696e-029.3104e-05-0.4689imageNBCCIP;CSTF2T;DDX42;DGCR8;EIF4A3;FAM120A;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;NONO;NOP56;NOP58;PTBP1;RBFOX2;SLTM;U2AF1;U2AF2;UPF1NANK_cells_activatedGSVA_HALLMARK_SPERMATOGENESIS

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4. Enriched editing regions and immune related splicing for TRIM69


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000185880.11,TRIM69
ESCAEAGA3ENSG00000115241.9chr227382125:27382228:27381193:27381721:27381193:27381759-0.18773.0570e-021.0670e-07-0.4338imageNADAR;CNBP;CPSF6;DDX3X;DGCR8;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;HNRNPA2B1;HNRNPD;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;LARP4B;LIN28B;MBNL2;METTL3;MOV10;MSI1;MSI2;NOP56;NOP58;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SAFB2;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;U2AF2;UPF1;YTHDC1;ZNF184NAGSVA_HALLMARK_MYC_TARGETS_V1
chr15:44733037-44735168:+
ESCAEERA3ENSG00000115241.9chr227382125:27382228:27381193:27381721:27381193:27381759-0.18672.6952e-021.2669e-07-0.4315imageNBCCIP;CSTF2T;DDX42;DGCR8;DHX9;EIF4A3;ELAVL1;FAM120A;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;NONO;NOP56;NOP58;PTBP1;RBFOX2;SLTM;U2AF1;U2AF2;UPF1NAGSVA_HALLMARK_MYC_TARGETS_V1
chr15:44733037-44735168:+
KICHEERESENSG00000166352.11chr1136633283:36633438:36636050:36636117:36648015:36648151-0.60092.7829e-021.5691e-07-0.6004imageNCSTF2T;DGCR8;DHX9;EIF4A3;ELAVL1;FAM120A;HNRNPM;NOP56;NOP58;PTBP1;RBFOX2;U2AF2;UPF1NAGSVA_HALLMARK_APICAL_SURFACE
ENSG00000185880.11,TRIM69
KICHEAGESENSG00000166352.11chr1136633283:36633438:36636050:36636117:36648015:36648151-0.60093.7901e-021.5691e-07-0.6004imageNADAR;CNBP;CPSF6;DDX3X;DGCR8;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FUS;HNRNPD;HNRNPL;IGF2BP1;IGF2BP2;IGF2BP3;LIN28B;MOV10;MSI1;MSI2;NOP56;NOP58;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;U2AF2;UPF1;ZNF184NAGSVA_HALLMARK_APICAL_SURFACE
chr15:44733037-44735168:+
UVMEERESENSG00000168675.14chr1813621116:13621271:13643358:13643412:13645126:136452050.41404.9557e-025.7109e-040.4658imageNBCCIP;CSTF2T;DGCR8;DHX9;EIF4A3;ELAVL1;FAM120A;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;NOP56;NOP58;PTBP1;RBFOX2;SLTM;U2AF1;U2AF2;UPF1NAT_cells_CD4_memory_resting
chr15:44733037-44735168:+
UVMEERIRENSG00000130827.5chrX154468302:154468559:154468662:154468729-0.40553.8081e-021.1891e-04-0.5175imageNBCCIP;CSTF2T;DDX42;DGCR8;DHX9;EIF4A3;ELAVL1;FAM120A;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;NONO;NOP58;PTBP1;RBFOX2;SLTM;U2AF1;U2AF2;UPF1PLXNA3T_cells_CD4_memory_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr15:44733037-44735168:+
UVMEERA3ENSG00000196872.6chr298796119:98796264:98793845:98794671:98793845:987946740.46263.6590e-024.4280e-040.4465imageNCSTF2T;DGCR8;DHX9;EIF4A3;ELAVL1;HNRNPC;NOP56;NOP58;PTBP1;RBFOX2;U2AF2;UPF1NAMacrophages_M1
chr15:44733037-44735168:+
UVMEERIRENSG00000138668.14chr482356536:82356683:82356798:823568950.24263.4525e-023.6034e-040.4388imageNBCCIP;CSTF2T;DDX42;DGCR8;DHX9;EIF4A3;ELAVL1;FAM120A;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;NONO;NOP56;NOP58;PTBP1;RBFOX2;SLTM;U2AF1;U2AF2;UPF1NAMast_cells_activatedGSVA_HALLMARK_E2F_TARGETS

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5. Enriched editing regions and immune infiltration for TRIM69


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr15:44733037-44735168:+BLCAEEREosinophils1.6377e-020.1303image
ENSG00000185880.11,TRIM69BLCAEAGEosinophils1.9749e-020.1266image
chr15:44733037-44735168:+BRCAEERB_cells_naive7.2250e-030.0876image
ENSG00000185880.11,TRIM69BRCAEAGB_cells_naive7.8377e-030.0867image
chr15:44733037-44735168:+CHOLEERB_cells_naive3.0106e-020.4103image
ENSG00000185880.11,TRIM69CHOLEAGMast_cells_resting2.5506e-02-0.4142image
chr15:44733037-44735168:+COADEERT_cells_CD81.9675e-020.1942image
ENSG00000185880.11,TRIM69COADEAGT_cells_CD81.9675e-020.1942image
ENSG00000185880.11,TRIM69DLBCEAGMacrophages_M23.6482e-02-0.3060image
chr15:44733037-44735168:+ESCAEERMacrophages_M22.2188e-030.2471image
ENSG00000185880.11,TRIM69ESCAEAGMacrophages_M21.9268e-030.2504image
chr15:44733037-44735168:+GBMEERT_cells_CD4_memory_resting2.1191e-02-0.1799image
ENSG00000185880.11,TRIM69GBMEAGT_cells_CD4_memory_resting2.1480e-02-0.1795image
chr15:44733037-44735168:+HNSCEERMast_cells_activated2.3973e-040.1718image
ENSG00000185880.11,TRIM69HNSCEAGMast_cells_activated2.4245e-040.1716image
chr15:44733037-44735168:+KICHEERMacrophages_M21.3491e-02-0.3074image
ENSG00000185880.11,TRIM69KICHEAGMacrophages_M21.3491e-02-0.3074image
chr15:44733037-44735168:+KIRPEERT_cells_CD4_memory_resting6.3241e-03-0.1643image
ENSG00000185880.11,TRIM69KIRPEAGT_cells_CD4_memory_resting6.3862e-03-0.1641image
chr15:44733037-44735168:+LGGEERMacrophages_M11.1712e-02-0.1099image
ENSG00000185880.11,TRIM69LGGEAGMacrophages_M11.1415e-02-0.1103image
chr15:44733037-44735168:+LIHCEERT_cells_CD4_memory_resting4.9037e-02-0.1482image
chr15:44733037-44735168:+MESOEEREosinophils1.9510e-050.4996image
ENSG00000185880.11,TRIM69MESOEAGEosinophils1.9510e-050.4996image
chr15:44733037-44735168:+OVEERB_cells_naive6.9620e-03-0.1607image
ENSG00000185880.11,TRIM69OVEAGB_cells_naive4.3946e-03-0.1694image
chr15:44733037-44735168:+PCPGEERMast_cells_activated2.3543e-030.2247image
ENSG00000185880.11,TRIM69PCPGEAGMast_cells_activated2.3194e-030.2250image
chr15:44733037-44735168:+PRADEERT_cells_follicular_helper1.4088e-02-0.1151image
ENSG00000185880.11,TRIM69PRADEAGT_cells_follicular_helper1.4145e-02-0.1151image
chr15:44733037-44735168:+SARCEERMacrophages_M14.2624e-02-0.1307image
ENSG00000185880.11,TRIM69SARCEAGMacrophages_M14.0428e-02-0.1321image
chr15:44733037-44735168:+SKCMEERB_cells_naive5.3395e-030.1367image
ENSG00000185880.11,TRIM69SKCMEAGPlasma_cells6.5714e-030.1334image
ENSG00000185880.11,TRIM69STADEAGT_cells_follicular_helper2.7803e-020.1285image
chr15:44733037-44735168:+THCAEERPlasma_cells1.5460e-050.1924image
ENSG00000185880.11,TRIM69THCAEAGPlasma_cells1.4922e-050.1927image
chr15:44733037-44735168:+THYMEERMacrophages_M02.1952e-03-0.2816image
ENSG00000185880.11,TRIM69THYMEAGMacrophages_M02.0730e-03-0.2831image
chr15:44733037-44735168:+UCSEERT_cells_gamma_delta4.8664e-02-0.3099image
ENSG00000185880.11,TRIM69UCSEAGT_cells_gamma_delta4.8664e-02-0.3099image
chr15:44733037-44735168:+UVMEERT_cells_CD4_memory_activated3.6883e-020.2636image
ENSG00000185880.11,TRIM69UVMEAGT_cells_CD4_memory_activated3.6883e-020.2636image


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6. Enriched editing regions and immune gene sets for TRIM69


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr15:44733037-44735168:+STADEER4.1731e-04image1.1662e-02-0.1479image
ENSG00000185880.11,TRIM69STADEAG2.9589e-04image1.1179e-02-0.1480image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000185880.11,TRIM69ACCGSVA_HALLMARK_UV_RESPONSE_DNEAG3.4077e-02-0.2764image
chr15:44733037-44735168:+ACCGSVA_HALLMARK_UV_RESPONSE_DNEER3.6500e-02-0.2729image
ENSG00000185880.11,TRIM69BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.1046e-05-0.1382image
chr15:44733037-44735168:+BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.1782e-05-0.1424image
chr15:44733037-44735168:+CESCGSVA_HALLMARK_UV_RESPONSE_DNEER3.9235e-020.1233image
ENSG00000185880.11,TRIM69CESCGSVA_HALLMARK_UV_RESPONSE_DNEAG3.9199e-020.1233image
ENSG00000185880.11,TRIM69CHOLGSVA_HALLMARK_MYC_TARGETS_V2EAG7.5424e-030.4858image
chr15:44733037-44735168:+CHOLGSVA_HALLMARK_MYC_TARGETS_V2EER3.8809e-030.5280image
ENSG00000185880.11,TRIM69COADGSVA_HALLMARK_UV_RESPONSE_UPEAG2.2841e-02-0.1896image
chr15:44733037-44735168:+COADGSVA_HALLMARK_UV_RESPONSE_UPEER2.2841e-02-0.1896image
chr15:44733037-44735168:+DLBCGSVA_HALLMARK_PROTEIN_SECRETIONEER1.7614e-020.3448image
ENSG00000185880.11,TRIM69DLBCGSVA_HALLMARK_PROTEIN_SECRETIONEAG3.5948e-020.3068image
ENSG00000185880.11,TRIM69ESCAGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.5218e-020.1972image
chr15:44733037-44735168:+ESCAGSVA_HALLMARK_DNA_REPAIREER1.7742e-020.1927image
ENSG00000185880.11,TRIM69GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2195e-03-0.2504image
chr15:44733037-44735168:+GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2045e-03-0.2507image
ENSG00000185880.11,TRIM69HNSCGSVA_HALLMARK_MYOGENESISEAG1.1880e-02-0.1181image
chr15:44733037-44735168:+HNSCGSVA_HALLMARK_MYOGENESISEER1.2973e-02-0.1167image
ENSG00000185880.11,TRIM69KICHGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.1593e-02-0.3137image
chr15:44733037-44735168:+KICHGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.1593e-02-0.3137image
ENSG00000185880.11,TRIM69KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.8156e-02-0.1218image
chr15:44733037-44735168:+KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.3265e-02-0.1278image
chr15:44733037-44735168:+KIRPGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER3.3298e-050.2475image
ENSG00000185880.11,TRIM69KIRPGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.4250e-050.2516image
chr15:44733037-44735168:+LGGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.1351e-03-0.1220image
ENSG00000185880.11,TRIM69LGGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.4026e-03-0.1213image
ENSG00000185880.11,TRIM69LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.4033e-02-0.1838image
chr15:44733037-44735168:+LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEER2.0123e-02-0.1746image
ENSG00000185880.11,TRIM69LUADGSVA_HALLMARK_DNA_REPAIREAG3.2081e-03-0.1615image
chr15:44733037-44735168:+LUADGSVA_HALLMARK_DNA_REPAIREER2.7682e-03-0.1642image
chr15:44733037-44735168:+LUSCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER4.7862e-020.0941image
ENSG00000185880.11,TRIM69LUSCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG4.9090e-020.0935image
chr15:44733037-44735168:+MESOGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER8.6941e-03-0.3205image
ENSG00000185880.11,TRIM69MESOGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG8.6941e-03-0.3205image
chr15:44733037-44735168:+PAADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER3.0470e-02-0.1750image
ENSG00000185880.11,TRIM69PAADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG3.0584e-02-0.1749image
ENSG00000185880.11,TRIM69PCPGGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG6.4866e-04-0.2512image
chr15:44733037-44735168:+PCPGGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER6.8358e-04-0.2501image
ENSG00000185880.11,TRIM69READGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.3402e-020.3251image
chr15:44733037-44735168:+READGSVA_HALLMARK_MITOTIC_SPINDLEEER3.3402e-020.3251image
chr15:44733037-44735168:+SARCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.1849e-020.1477image
ENSG00000185880.11,TRIM69SARCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.2582e-020.1469image
chr15:44733037-44735168:+SKCMGSVA_HALLMARK_MYOGENESISEER6.0561e-03-0.1347image
ENSG00000185880.11,TRIM69SKCMGSVA_HALLMARK_MYOGENESISEAG4.5140e-03-0.1393image
chr15:44733037-44735168:+STADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER1.1662e-02-0.1479image
ENSG00000185880.11,TRIM69STADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG4.3265e-03-0.1662image
chr15:44733037-44735168:+TGCTGSVA_HALLMARK_G2M_CHECKPOINTEER9.6168e-03-0.2493image
ENSG00000185880.11,TRIM69TGCTGSVA_HALLMARK_G2M_CHECKPOINTEAG4.5436e-03-0.2711image
ENSG00000185880.11,TRIM69THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.6372e-090.2660image
chr15:44733037-44735168:+THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER1.6414e-090.2660image
ENSG00000185880.11,TRIM69THYMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.2326e-02-0.2120image
chr15:44733037-44735168:+THYMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.1773e-02-0.2129image
ENSG00000185880.11,TRIM69UCECGSVA_HALLMARK_SPERMATOGENESISEAG1.3666e-02-0.2087image
chr15:44733037-44735168:+UCECGSVA_HALLMARK_SPERMATOGENESISEER3.7772e-02-0.1777image
ENSG00000185880.11,TRIM69UVMGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.5705e-02-0.2652image
chr15:44733037-44735168:+UVMGSVA_HALLMARK_MITOTIC_SPINDLEEER3.5705e-02-0.2652image


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7. Enriched editing regions and drugs for TRIM69


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000185880.11,TRIM69ACCAxitinibEAG2.1834e-020.2981image
chr15:44733037-44735168:+ACCAUY922EER1.8483e-020.3058image
ENSG00000185880.11,TRIM69BLCAAS601245EAG4.5284e-030.1538image
chr15:44733037-44735168:+BLCAAS601245EER4.4915e-030.1540image
ENSG00000185880.11,TRIM69BRCACHIR.99021EAG2.4853e-02-0.0732image
chr15:44733037-44735168:+BRCAEmbelinEER2.6664e-020.0723image
chr15:44733037-44735168:+CESCEHT.1864EER4.9895e-030.1674image
ENSG00000185880.11,TRIM69CESCEHT.1864EAG5.2116e-030.1665image
ENSG00000185880.11,TRIM69CHOLAKT.inhibitor.VIIIEAG1.1069e-020.4648image
chr15:44733037-44735168:+CHOLAKT.inhibitor.VIIIEER2.4794e-020.4233image
ENSG00000185880.11,TRIM69COADCGP.082996EAG1.9982e-020.1937image
chr15:44733037-44735168:+COADCGP.082996EER1.9982e-020.1937image
chr15:44733037-44735168:+DLBCBexaroteneEER2.6112e-04-0.5087image
ENSG00000185880.11,TRIM69DLBCBexaroteneEAG5.9186e-04-0.4826image
ENSG00000185880.11,TRIM69ESCAGefitinibEAG2.0182e-020.1895image
chr15:44733037-44735168:+ESCAGefitinibEER2.3701e-020.1846image
ENSG00000185880.11,TRIM69GBMABT.888EAG5.6632e-030.2152image
chr15:44733037-44735168:+GBMABT.888EER5.6740e-030.2151image
ENSG00000185880.11,TRIM69HNSCGNF.2EAG9.3654e-040.1555image
chr15:44733037-44735168:+HNSCGNF.2EER1.0606e-030.1538image
ENSG00000185880.11,TRIM69KICHCGP.082996EAG2.1785e-040.4464image
chr15:44733037-44735168:+KICHCGP.082996EER2.1785e-040.4464image
ENSG00000185880.11,TRIM69KIRCDocetaxelEAG1.7273e-030.1611image
chr15:44733037-44735168:+KIRCDocetaxelEER2.3115e-030.1569image
chr15:44733037-44735168:+KIRPFH535EER1.4108e-04-0.2275image
ENSG00000185880.11,TRIM69KIRPFH535EAG1.0285e-04-0.2320image
ENSG00000185880.11,TRIM69LGGFH535EAG5.2938e-05-0.1755image
chr15:44733037-44735168:+LGGFH535EER4.8548e-05-0.1763image
ENSG00000185880.11,TRIM69LIHCErlotinibEAG9.3664e-030.2101image
chr15:44733037-44735168:+LIHCAZ628EER9.4521e-03-0.1974image
ENSG00000185880.11,TRIM69LUADLFM.A13EAG3.4412e-02-0.1163image
chr15:44733037-44735168:+LUADLFM.A13EER4.5119e-02-0.1104image
ENSG00000185880.11,TRIM69LUSCBX.795EAG3.9716e-03-0.1366image
chr15:44733037-44735168:+LUSCBX.795EER3.5914e-03-0.1381image
chr15:44733037-44735168:+MESOCGP.60474EER1.6612e-020.2939image
ENSG00000185880.11,TRIM69MESOCGP.60474EAG1.6612e-020.2939image
ENSG00000185880.11,TRIM69OVGNF.2EAG2.1084e-03-0.1827image
chr15:44733037-44735168:+OVGNF.2EER1.0017e-03-0.1953image
ENSG00000185880.11,TRIM69PAADAS601245EAG5.5573e-03-0.2246image
chr15:44733037-44735168:+PAADAS601245EER5.6067e-03-0.2244image
chr15:44733037-44735168:+PCPGBortezomibEER4.2115e-030.2118image
ENSG00000185880.11,TRIM69PCPGBortezomibEAG4.4780e-030.2104image
chr15:44733037-44735168:+READBexaroteneEER5.3964e-03-0.4171image
ENSG00000185880.11,TRIM69READBexaroteneEAG5.3964e-03-0.4171image
chr15:44733037-44735168:+SARCMG.132EER8.0789e-03-0.1703image
ENSG00000185880.11,TRIM69SARCMG.132EAG8.2552e-03-0.1698image
chr15:44733037-44735168:+SKCMBMS.708163EER2.1608e-04-0.1809image
ENSG00000185880.11,TRIM69SKCMBMS.708163EAG2.0774e-04-0.1813image
chr15:44733037-44735168:+STADAZ628EER7.1120e-040.1977image
ENSG00000185880.11,TRIM69STADAZ628EAG9.4183e-050.2261image
chr15:44733037-44735168:+TGCTDasatinibEER6.2966e-03-0.2625image
ENSG00000185880.11,TRIM69TGCTDasatinibEAG5.5913e-03-0.2649image
ENSG00000185880.11,TRIM69THCACI.1040EAG1.3799e-08-0.2509image
chr15:44733037-44735168:+THCACI.1040EER1.3349e-08-0.2511image
chr15:44733037-44735168:+UCECCGP.082996EER3.7489e-030.2461image
ENSG00000185880.11,TRIM69UCECCGP.082996EAG6.3250e-030.2306image
ENSG00000185880.11,TRIM69UCSBX.795EAG2.8820e-020.3416image
chr15:44733037-44735168:+UCSBX.795EER2.8820e-020.3416image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType