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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: APOOL (ImmuneEditome ID:139322)

1. Gene summary of enriched editing regions for APOOL

check button Gene summary
Gene informationGene symbol

APOOL

Gene ID

139322

GeneSynonymsCXorf33|FAM121A|MICOS27|Mic27|UNQ8193
GeneCytomap

Xq21.1

GeneTypeprotein-coding
GeneDescriptionMICOS complex subunit MIC27|AAIR8193|family with sequence similarity 121A|mitochondrial contact site and cristae organizing system subunit 27
GeneModificationdate20230329
UniprotIDQ6UXV4
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chrX:85088057-85089404:+ENST00000373173.5ENSG00000155008.12APOOLUTR3L2c,AluSx3,(T)nchrX:85088057-85089404:+.alignment
chrX:85088057-85089404:+ENST00000613473.1ENSG00000155008.12APOOLUTR3L2c,AluSx3,(T)nchrX:85088057-85089404:+.alignment
chrX:85088057-85089404:+ENST00000622540.3ENSG00000155008.12APOOLUTR3L2c,AluSx3,(T)nchrX:85088057-85089404:+.alignment
chrX:85090780-85092047:+ENST00000613473.1ENSG00000155008.12APOOLUTR3FLAM_C,AluSq2,Tigger19b,Kanga1c,L2cchrX:85090780-85092047:+.alignment
chrX:85090780-85092047:+ENST00000622540.3ENSG00000155008.12APOOLUTR3FLAM_C,AluSq2,Tigger19b,Kanga1c,L2cchrX:85090780-85092047:+.alignment


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2. Tumor-specific enriched editing regions for APOOL


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chrX:85088057-85089404:+BRCAEER4.7233e-04image
chrX:85090780-85092047:+BRCAEER1.6779e-38image
ENSG00000155008.12,APOOLBRCAEAG6.8311e-37image
chrX:85090780-85092047:+COADEER1.2995e-09image
ENSG00000155008.12,APOOLCOADEAG2.9613e-10image
chrX:85090780-85092047:+HNSCEER7.6972e-11image
ENSG00000155008.12,APOOLHNSCEAG9.0419e-11image
chrX:85090780-85092047:+KICHEER1.4532e-10image
ENSG00000155008.12,APOOLKICHEAG6.0677e-11image
chrX:85090780-85092047:+KIRCEER5.5294e-12image
ENSG00000155008.12,APOOLKIRCEAG8.8046e-13image
chrX:85090780-85092047:+LIHCEER2.1800e-03image
ENSG00000155008.12,APOOLLIHCEAG1.9268e-03image
chrX:85090780-85092047:+LUADEER3.7238e-02image
chrX:85090780-85092047:+LUSCEER5.1158e-03image
ENSG00000155008.12,APOOLLUSCEAG7.9381e-03image
chrX:85090780-85092047:+PRADEER7.2563e-04image
ENSG00000155008.12,APOOLPRADEAG8.6747e-04image
chrX:85090780-85092047:+THCAEER5.8660e-21image
ENSG00000155008.12,APOOLTHCAEAG2.1461e-20image
chrX:85090780-85092047:+UCECEER9.3625e-03image
ENSG00000155008.12,APOOLUCECEAG9.8056e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000155008.12,APOOLBRCAPathEAG5.2020e-031.0597e-020.0788image
chrX:85090780-85092047:+BRCAPathEER3.9760e-036.3068e-030.0842image
chrX:85090780-85092047:+KIRCPathEER1.8309e-044.5996e-050.1779image
ENSG00000155008.12,APOOLKIRCPathEAG3.6311e-047.5033e-050.1729image
chrX:85090780-85092047:+KIRPPathEER1.6954e-023.4107e-020.1374image
ENSG00000155008.12,APOOLKIRPPathEAG1.9537e-023.6849e-020.1354image
chrX:85090780-85092047:+THCAPathEER2.7978e-054.0560e-040.1601image
ENSG00000155008.12,APOOLTHCAPathEAG1.8682e-053.1916e-040.1629image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for APOOL


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chrX:85088057-85089404:+STADEERENSG00000155008,APOOL-0.49161.7827e-151.0471e-14-0.4173imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_ALLOGRAFT_REJECTION
chrX:85088057-85089404:+STADEERENSG00000155008,APOOL-0.49161.7827e-151.0471e-14-0.4173imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_ALLOGRAFT_REJECTION
chrX:85088057-85089404:+STADEERENSG00000155008,APOOL-0.49161.7827e-151.0471e-14-0.4173imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_ALLOGRAFT_REJECTION
chrX:85090780-85092047:+BLCAEERENSG00000134470,IL15RA0.46921.1086e-163.4179e-160.4186imageNNIL15RAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chrX:85090780-85092047:+BLCAEERENSG00000240065,PSMB90.44497.2483e-154.0912e-150.4043imageNNPSMB9T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chrX:85090780-85092047:+BLCAEERENSG00000204267,TAP20.44597.3267e-151.3549e-160.4237imageNNTAP2T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chrX:85090780-85092047:+BLCAEERENSG00000158869,FCER1G0.43252.1696e-146.1208e-150.4019imageNNFCER1GT_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chrX:85090780-85092047:+BLCAEERENSG00000275302,CCL40.43463.5343e-145.1995e-150.4028imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chrX:85090780-85092047:+BLCAEERENSG00000234745,HLA-B0.43474.4146e-143.2692e-160.4188imageNNHLA-BT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chrX:85090780-85092047:+BLCAEERENSG00000135077,HAVCR20.42785.9142e-145.6603e-170.4285imageNNHAVCR2T_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chrX:85090780-85092047:+BLCAEERENSG00000156587,UBE2L60.42233.1849e-133.2940e-200.4665imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chrX:85090780-85092047:+BLCAEERENSG00000166710,B2M0.41765.7780e-131.4407e-160.4234imageNNB2MT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chrX:85090780-85092047:+BLCAEERENSG00000123609,NMI0.41331.1565e-121.7070e-160.4224imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chrX:85090780-85092047:+BLCAEERENSG00000134470,IL15RA0.46921.1086e-163.4179e-160.4186imageNNIL15RAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chrX:85090780-85092047:+BLCAEERENSG00000240065,PSMB90.44497.2483e-154.0912e-150.4043imageNNPSMB9T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chrX:85090780-85092047:+BLCAEERENSG00000204267,TAP20.44597.3267e-151.3549e-160.4237imageNNTAP2T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chrX:85090780-85092047:+BLCAEERENSG00000158869,FCER1G0.43252.1696e-146.1208e-150.4019imageNNFCER1GT_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chrX:85090780-85092047:+BLCAEERENSG00000275302,CCL40.43463.5343e-145.1995e-150.4028imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chrX:85090780-85092047:+BLCAEERENSG00000234745,HLA-B0.43474.4146e-143.2692e-160.4188imageNNHLA-BT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chrX:85090780-85092047:+BLCAEERENSG00000135077,HAVCR20.42785.9142e-145.6603e-170.4285imageNNHAVCR2T_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chrX:85090780-85092047:+BLCAEERENSG00000156587,UBE2L60.42233.1849e-133.2940e-200.4665imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chrX:85090780-85092047:+BLCAEERENSG00000166710,B2M0.41765.7780e-131.4407e-160.4234imageNNB2MT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chrX:85090780-85092047:+BLCAEERENSG00000123609,NMI0.41331.1565e-121.7070e-160.4224imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE

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4. Enriched editing regions and immune related splicing for APOOL


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000155008.12,APOOL
BLCAEAGIRENSG00000122481.12chr195244210:95244698:95246541:95246657-0.34703.0175e-095.4887e-14-0.4045imageNADAR;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FUS;FXR2;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHDRBS3;LARP4B;LIN28B;MOV10;MSI1;NOP56;NOP58;PRPF8;PTBP1;RBFOX2;RBM10;RBM22;RBM47;RBM5;RC3H1;SLTM;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIAL1;U2AF2;UPF1;ZC3H7BNAT_cells_CD4_memory_activatedGSVA_HALLMARK_UV_RESPONSE_UP
chrX:85090780-85092047:+
BLCAEERIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.51923.9962e-191.2231e-23-0.5029imageNNPRKCSHMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000155008.12,APOOL
BLCAEAGIRENSG00000153048.6chr168857463:8859335:8860104:8860131-0.30374.2446e-087.4047e-12-0.4011imageNADAR;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FTO;FUS;FXR2;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;LARP4B;LIN28A;LIN28B;METTL14;MOV10;MSI1;MSI2;NOP56;NOP58;PRPF8;PTBP1;RBFOX2;RBM10;RBM22;RC3H1;SLTM;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIAL1;TRA2A;U2AF2;UPF1;YTHDC1;YTHDF1;ZC3H7BNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000155008.12,APOOL
BLCAEAGIRENSG00000185482.3chr1257244314:57244622:57244915:57244965-0.29606.7897e-082.7449e-11-0.4014imageNADAR;BCCIP;CELF2;CNBP;CSTF2T;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FUS;HNRNPA1;HNRNPC;IGF2BP2;KHDRBS1;LIN28B;NOP56;NOP58;PRPF8;PTBP1;RBFOX2;RBM10;SLTM;SRSF1;TAF15;TARDBP;TRA2A;U2AF2NAMacrophages_M1GSVA_HALLMARK_COMPLEMENT
ENSG00000155008.12,APOOL
BLCAEAGIRENSG00000083457.7chr173723263:3723383:3723687:3723744-0.28481.1435e-074.5463e-13-0.4298imageNADAR;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FTO;FUS;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHDRBS3;LARP4B;LIN28B;MOV10;MSI1;NOP56;NOP58;PRPF8;PTBP1;QKI;RBFOX2;RBM10;RBM22;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIAL1;U2AF2;UPF1;YTHDF1ITGAET_cells_CD4_memory_activatedGSVA_HALLMARK_UV_RESPONSE_UP
chrX:85090780-85092047:+
BLCAEERIRENSG00000122481.12chr195244210:95244698:95246541:95246657-0.35041.3692e-093.1833e-14-0.4080imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_UV_RESPONSE_UP
chrX:85090780-85092047:+
BLCAEERIRENSG00000135698.5chr1682149308:82149403:82151237:82151337-0.30277.3607e-091.9464e-11-0.4012imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_UV_RESPONSE_UP
chrX:85090780-85092047:+
BLCAEERIRENSG00000153048.6chr168857463:8859335:8860104:8860131-0.30731.9592e-084.1973e-12-0.4054imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000155008.12,APOOL
BLCAEAGIRENSG00000139725.3chr12121777757:121779662:121780871:121781006-0.39111.1047e-114.9400e-15-0.4178imageNADAR;BCCIP;BUD13;CELF2;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FTO;FUS;FXR2;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;LIN28B;MBNL2;MOV10;MSI1;NOP56;NOP58;PRPF8;PTBP1;RBFOX2;RBM10;RBM22;SLTM;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIAL1;TRA2A;U2AF2;UPF1;YTHDC1;YTHDF1NAMacrophages_M1GSVA_HALLMARK_COMPLEMENT
chrX:85090780-85092047:+
BLCAEERIRENSG00000185482.3chr1257244314:57244622:57244915:57244965-0.29764.0655e-082.3027e-11-0.4028imageNNNAMacrophages_M1GSVA_HALLMARK_COMPLEMENT

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5. Enriched editing regions and immune infiltration for APOOL


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chrX:85090780-85092047:+ACCEERMacrophages_M23.1359e-020.2613image
ENSG00000155008.12,APOOLACCEAGMacrophages_M23.0687e-020.2623image
chrX:85090780-85092047:+BLCAEERT_cells_CD4_memory_activated2.2945e-120.3644image
ENSG00000155008.12,APOOLBLCAEAGT_cells_CD4_memory_activated1.8189e-120.3659image
chrX:85088057-85089404:+BRCAEERPlasma_cells1.5832e-020.1054image
chrX:85090780-85092047:+BRCAEERT_cells_regulatory_(Tregs)1.2625e-100.1962image
ENSG00000155008.12,APOOLBRCAEAGT_cells_regulatory_(Tregs)1.1602e-100.1966image
chrX:85090780-85092047:+CESCEERDendritic_cells_activated4.4061e-050.2514image
ENSG00000155008.12,APOOLCESCEAGDendritic_cells_activated4.0078e-050.2528image
chrX:85090780-85092047:+CHOLEERT_cells_regulatory_(Tregs)1.1592e-020.4341image
ENSG00000155008.12,APOOLCHOLEAGT_cells_regulatory_(Tregs)1.2562e-020.4297image
chrX:85090780-85092047:+COADEERMacrophages_M11.2703e-040.2307image
ENSG00000155008.12,APOOLCOADEAGMacrophages_M15.5028e-030.1679image
chrX:85088057-85089404:+ESCAEERPlasma_cells2.5508e-020.1915image
chrX:85090780-85092047:+ESCAEERT_cells_regulatory_(Tregs)1.7180e-03-0.2460image
ENSG00000155008.12,APOOLESCAEAGT_cells_regulatory_(Tregs)1.0270e-03-0.2572image
chrX:85088057-85089404:+GBMEERMacrophages_M03.3509e-02-0.2683image
chrX:85090780-85092047:+GBMEERMacrophages_M05.9672e-06-0.3514image
ENSG00000155008.12,APOOLGBMEAGMacrophages_M04.7145e-06-0.3550image
chrX:85090780-85092047:+HNSCEERB_cells_naive1.3473e-03-0.1512image
ENSG00000155008.12,APOOLHNSCEAGB_cells_naive1.6789e-03-0.1482image
chrX:85090780-85092047:+KICHEERT_cells_CD4_memory_activated4.6590e-050.4827image
ENSG00000155008.12,APOOLKICHEAGT_cells_CD4_memory_activated3.0996e-050.4924image
chrX:85088057-85089404:+KIRCEERB_cells_naive4.4168e-030.2297image
chrX:85090780-85092047:+KIRCEERMacrophages_M21.9781e-07-0.2637image
ENSG00000155008.12,APOOLKIRCEAGT_cells_CD82.4318e-070.2618image
chrX:85090780-85092047:+KIRPEERT_cells_CD4_memory_resting2.4867e-07-0.3105image
ENSG00000155008.12,APOOLKIRPEAGT_cells_CD4_memory_resting2.2671e-07-0.3115image
chrX:85088057-85089404:+LAMLEERNK_cells_resting4.5860e-02-0.3136image
chrX:85090780-85092047:+LAMLEERDendritic_cells_activated1.4727e-020.2331image
chrX:85090780-85092047:+LGGEERMacrophages_M12.2700e-050.1855image
ENSG00000155008.12,APOOLLGGEAGMacrophages_M13.5508e-050.1811image
chrX:85090780-85092047:+LIHCEERMacrophages_M11.7899e-040.2033image
ENSG00000155008.12,APOOLLIHCEAGMacrophages_M13.0824e-040.1960image
chrX:85090780-85092047:+LUADEERT_cells_CD4_memory_activated1.6629e-060.2121image
ENSG00000155008.12,APOOLLUADEAGT_cells_CD4_memory_activated1.9494e-060.2107image
chrX:85090780-85092047:+LUSCEERT_cells_CD4_memory_activated2.6017e-060.2131image
ENSG00000155008.12,APOOLLUSCEAGT_cells_CD4_memory_activated5.5961e-060.2060image
chrX:85090780-85092047:+MESOEERT_cells_CD82.0554e-030.3438image
ENSG00000155008.12,APOOLMESOEAGT_cells_CD82.1027e-030.3431image
chrX:85088057-85089404:+OVEERMacrophages_M02.1380e-02-0.1729image
chrX:85090780-85092047:+OVEERT_cells_CD81.5409e-070.3063image
ENSG00000155008.12,APOOLOVEAGT_cells_CD81.2297e-070.3086image
chrX:85090780-85092047:+PAADEERMacrophages_M05.3197e-030.2122image
ENSG00000155008.12,APOOLPAADEAGMacrophages_M02.8609e-030.2268image
chrX:85090780-85092047:+PCPGEERT_cells_CD81.2273e-030.2488image
ENSG00000155008.12,APOOLPCPGEAGT_cells_CD81.2560e-030.2483image
chrX:85088057-85089404:+PRADEERT_cells_CD4_memory_resting4.5721e-02-0.1623image
chrX:85090780-85092047:+PRADEERT_cells_CD81.4540e-030.1452image
ENSG00000155008.12,APOOLPRADEAGT_cells_CD81.2738e-030.1470image
chrX:85090780-85092047:+SARCEERT_cells_CD4_memory_activated2.6133e-030.1976image
ENSG00000155008.12,APOOLSARCEAGT_cells_CD4_memory_activated2.5811e-030.1978image
chrX:85088057-85089404:+SKCMEERMacrophages_M21.4564e-020.2244image
chrX:85090780-85092047:+SKCMEERT_cells_CD81.6453e-110.3162image
ENSG00000155008.12,APOOLSKCMEAGT_cells_CD81.8342e-110.3155image
chrX:85088057-85089404:+STADEERT_cells_CD84.7946e-030.1585image
chrX:85090780-85092047:+STADEERT_cells_CD4_memory_activated9.1771e-040.1740image
ENSG00000155008.12,APOOLSTADEAGT_cells_CD88.3119e-060.2315image
chrX:85090780-85092047:+TGCTEERMacrophages_M21.5387e-07-0.4407image
ENSG00000155008.12,APOOLTGCTEAGMacrophages_M21.3987e-07-0.4421image
chrX:85090780-85092047:+THCAEERT_cells_regulatory_(Tregs)1.0888e-080.2559image
ENSG00000155008.12,APOOLTHCAEAGT_cells_regulatory_(Tregs)1.9754e-080.2515image
chrX:85090780-85092047:+THYMEERT_cells_gamma_delta3.7753e-030.3146image
ENSG00000155008.12,APOOLTHYMEAGT_cells_gamma_delta3.7608e-030.3147image
chrX:85090780-85092047:+UCECEERT_cells_CD4_memory_resting4.5156e-04-0.2926image
ENSG00000155008.12,APOOLUCECEAGT_cells_CD4_memory_resting6.4278e-04-0.2840image
chrX:85090780-85092047:+UVMEERT_cells_CD4_memory_resting2.4333e-03-0.3906image
ENSG00000155008.12,APOOLUVMEAGT_cells_CD4_memory_resting2.4516e-03-0.3903image


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6. Enriched editing regions and immune gene sets for APOOL


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000155008.12,APOOLBLCAEAG1.1243e-050.23301.6048e-020.12902.8204e-050.22251.3994e-080.2982image
chrX:85090780-85092047:+BLCAEER1.3008e-050.23141.7998e-020.12683.5649e-050.21971.2963e-080.2989image
ENSG00000155008.12,APOOLLUADEAG7.3665e-070.21912.8908e-050.18572.3851e-050.18762.3178e-090.2628image
chrX:85090780-85092047:+LUADEER9.6155e-070.21682.2356e-050.18822.6349e-050.18664.3849e-090.2584image
ENSG00000155008.12,APOOLPAADEAG1.7028e-020.18233.1976e-020.16414.3707e-020.15448.6809e-030.2001image
chrX:85090780-85092047:+PAADEER1.8772e-020.17962.5705e-020.17064.2885e-020.15501.3501e-020.1886image
chrX:85090780-85092047:+STADEER8.4537e-090.29775.6776e-030.14551.4224e-060.25096.8935e-040.1781image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chrX:85090780-85092047:+ACCGSVA_HALLMARK_PROTEIN_SECRETIONEER1.5625e-02-0.2922image
ENSG00000155008.12,APOOLACCGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.1402e-02-0.3051image
ENSG00000155008.12,APOOLBLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG4.0383e-190.4542image
chrX:85090780-85092047:+BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER3.5169e-190.4549image
chrX:85088057-85089404:+BRCAGSVA_HALLMARK_P53_PATHWAYEER1.9795e-030.1348image
ENSG00000155008.12,APOOLBRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG9.3962e-420.3996image
chrX:85090780-85092047:+BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.7478e-420.4006image
chrX:85090780-85092047:+CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.5624e-110.4037image
ENSG00000155008.12,APOOLCESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.3206e-110.4050image
ENSG00000155008.12,APOOLCOADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG3.9392e-060.2756image
chrX:85090780-85092047:+COADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER2.8960e-100.3709image
chrX:85090780-85092047:+DLBCGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.2069e-020.4678image
ENSG00000155008.12,APOOLDLBCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.2392e-020.4662image
chrX:85090780-85092047:+ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER8.4105e-040.2614image
ENSG00000155008.12,APOOLESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.9156e-040.2908image
ENSG00000155008.12,APOOLGBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.7270e-110.4911image
chrX:85090780-85092047:+GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.1160e-110.4969image
chrX:85088057-85089404:+GBMGSVA_HALLMARK_MITOTIC_SPINDLEEER2.9405e-02-0.2746image
ENSG00000155008.12,APOOLHNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.6722e-100.2962image
chrX:85090780-85092047:+HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2510e-100.2982image
ENSG00000155008.12,APOOLKICHGSVA_HALLMARK_APICAL_SURFACEEAG4.8022e-05-0.4820image
chrX:85090780-85092047:+KICHGSVA_HALLMARK_APICAL_SURFACEEER4.0111e-05-0.4863image
chrX:85088057-85089404:+KIRCGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.7808e-020.1920image
ENSG00000155008.12,APOOLKIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.8142e-130.3593image
chrX:85090780-85092047:+KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.0249e-130.3602image
chrX:85090780-85092047:+KIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER5.9090e-100.3687image
ENSG00000155008.12,APOOLKIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG5.1657e-100.3698image
chrX:85090780-85092047:+LAMLGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.1063e-020.2067image
chrX:85088057-85089404:+LAMLGSVA_HALLMARK_ADIPOGENESISEER2.3966e-050.6089image
chrX:85090780-85092047:+LGGGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER2.1136e-310.4826image
chrX:85088057-85089404:+LGGGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER1.3315e-03-0.2580image
ENSG00000155008.12,APOOLLGGGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG4.6350e-310.4802image
chrX:85090780-85092047:+LIHCGSVA_HALLMARK_COAGULATIONEER1.2636e-070.2838image
chrX:85088057-85089404:+LIHCGSVA_HALLMARK_PROTEIN_SECRETIONEER3.7569e-02-0.1855image
ENSG00000155008.12,APOOLLIHCGSVA_HALLMARK_COAGULATIONEAG1.0047e-070.2860image
chrX:85090780-85092047:+LUADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.0758e-110.2975image
ENSG00000155008.12,APOOLLUADGSVA_HALLMARK_UV_RESPONSE_UPEAG4.6247e-120.3025image
chrX:85090780-85092047:+LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.7643e-110.2964image
ENSG00000155008.12,APOOLLUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.6263e-110.2951image
ENSG00000155008.12,APOOLMESOGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG7.1031e-040.3753image
chrX:85090780-85092047:+MESOGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER7.2697e-040.3746image
ENSG00000155008.12,APOOLOVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.5934e-140.4308image
chrX:85090780-85092047:+OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.3438e-140.4373image
chrX:85088057-85089404:+OVGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER6.0458e-030.2056image
chrX:85090780-85092047:+PAADGSVA_HALLMARK_P53_PATHWAYEER8.9828e-060.3323image
ENSG00000155008.12,APOOLPAADGSVA_HALLMARK_P53_PATHWAYEAG6.0960e-060.3381image
chrX:85090780-85092047:+PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.0647e-040.2768image
ENSG00000155008.12,APOOLPCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.5748e-040.2801image
chrX:85090780-85092047:+PRADGSVA_HALLMARK_PROTEIN_SECRETIONEER7.3888e-11-0.2921image
ENSG00000155008.12,APOOLPRADGSVA_HALLMARK_PROTEIN_SECRETIONEAG6.7830e-11-0.2927image
chrX:85088057-85089404:+PRADGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.2941e-020.1844image
chrX:85090780-85092047:+READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.2424e-040.3581image
ENSG00000155008.12,APOOLREADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.7712e-040.3686image
chrX:85088057-85089404:+SARCGSVA_HALLMARK_KRAS_SIGNALING_DNEER4.1104e-02-0.3521image
ENSG00000155008.12,APOOLSARCGSVA_HALLMARK_COMPLEMENTEAG1.4472e-060.3115image
chrX:85090780-85092047:+SARCGSVA_HALLMARK_COMPLEMENTEER1.1202e-060.3146image
ENSG00000155008.12,APOOLSKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.2727e-110.3141image
chrX:85090780-85092047:+SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.8249e-110.3155image
chrX:85088057-85089404:+SKCMGSVA_HALLMARK_MITOTIC_SPINDLEEER2.0268e-02-0.2135image
ENSG00000155008.12,APOOLSTADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.2878e-200.4540image
chrX:85088057-85089404:+STADGSVA_HALLMARK_MITOTIC_SPINDLEEER3.4110e-05-0.2312image
chrX:85090780-85092047:+STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER9.8152e-190.4430image
chrX:85090780-85092047:+TGCTGSVA_HALLMARK_ANGIOGENESISEER1.1670e-07-0.4446image
ENSG00000155008.12,APOOLTGCTGSVA_HALLMARK_ANGIOGENESISEAG1.1663e-07-0.4446image
chrX:85090780-85092047:+THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER1.0742e-230.4340image
ENSG00000155008.12,APOOLTHCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG4.7687e-240.4371image
chrX:85090780-85092047:+THYMGSVA_HALLMARK_PANCREAS_BETA_CELLSEER8.4640e-030.2872image
ENSG00000155008.12,APOOLTHYMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG8.1166e-030.2887image
chrX:85090780-85092047:+UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.5365e-030.2653image
ENSG00000155008.12,APOOLUCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.3492e-030.2674image
chrX:85090780-85092047:+UCSGSVA_HALLMARK_MYOGENESISEER1.5219e-04-0.5351image
ENSG00000155008.12,APOOLUCSGSVA_HALLMARK_MYOGENESISEAG1.5109e-04-0.5354image
ENSG00000155008.12,APOOLUVMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG6.9266e-050.4981image
chrX:85090780-85092047:+UVMGSVA_HALLMARK_KRAS_SIGNALING_DNEER7.2277e-050.4970image


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7. Enriched editing regions and drugs for APOOL


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chrX:85090780-85092047:+ACCJW.7.52.1EER3.9041e-03-0.3455image
ENSG00000155008.12,APOOLACCJW.7.52.1EAG2.7661e-03-0.3575image
chrX:85090780-85092047:+BLCACGP.60474EER1.5063e-16-0.4231image
ENSG00000155008.12,APOOLBLCACGP.60474EAG1.4313e-16-0.4234image
chrX:85088057-85089404:+BRCABMS.509744EER2.9404e-07-0.2217image
ENSG00000155008.12,APOOLBRCACGP.082996EAG2.5173e-13-0.2226image
chrX:85090780-85092047:+BRCACGP.082996EER2.6114e-12-0.2131image
ENSG00000155008.12,APOOLCESCCI.1040EAG3.7962e-07-0.3099image
chrX:85090780-85092047:+CESCCI.1040EER4.5923e-07-0.3078image
ENSG00000155008.12,APOOLCHOLDocetaxelEAG3.6352e-020.3657image
chrX:85090780-85092047:+CHOLDocetaxelEER3.5555e-020.3672image
chrX:85090780-85092047:+COADBI.D1870EER4.7873e-09-0.3462image
ENSG00000155008.12,APOOLCOADGefitinibEAG4.1269e-07-0.3012image
chrX:85090780-85092047:+DLBCAZD.2281EER1.2627e-02-0.4651image
ENSG00000155008.12,APOOLDLBCAZD.2281EAG1.3475e-02-0.4613image
ENSG00000155008.12,APOOLESCAKU.55933EAG3.9103e-04-0.2779image
chrX:85090780-85092047:+ESCAAZD6244EER2.0330e-03-0.2422image
chrX:85088057-85089404:+ESCAAZD.2281EER4.2848e-03-0.2444image
ENSG00000155008.12,APOOLGBMBIBW2992EAG1.3899e-09-0.4584image
chrX:85088057-85089404:+GBMCI.1040EER3.5952e-02-0.2648image
chrX:85090780-85092047:+GBMBIBW2992EER1.2642e-09-0.4594image
ENSG00000155008.12,APOOLHNSCErlotinibEAG1.2396e-07-0.2469image
chrX:85090780-85092047:+HNSCErlotinibEER1.2015e-07-0.2472image
ENSG00000155008.12,APOOLKICHAKT.inhibitor.VIIIEAG1.9114e-060.5516image
chrX:85090780-85092047:+KICHAKT.inhibitor.VIIIEER2.5624e-060.5459image
chrX:85088057-85089404:+KIRCAZD6244EER1.2251e-02-0.2027image
ENSG00000155008.12,APOOLKIRCGDC.0449EAG1.2263e-13-0.3695image
chrX:85090780-85092047:+KIRCGDC.0449EER1.9509e-13-0.3666image
ENSG00000155008.12,APOOLKIRPCCT007093EAG1.3892e-160.4787image
chrX:85090780-85092047:+KIRPCCT007093EER2.2807e-160.4757image
chrX:85090780-85092047:+LAMLBIRB.0796EER3.7524e-02-0.1995image
chrX:85088057-85089404:+LAMLAZD6244EER6.2555e-03-0.4200image
ENSG00000155008.12,APOOLLAMLA.443654EAG4.2660e-020.1862image
ENSG00000155008.12,APOOLLGGMG.132EAG2.0764e-34-0.5032image
chrX:85090780-85092047:+LGGMG.132EER7.4651e-34-0.4995image
chrX:85088057-85089404:+LGGBryostatin.1EER2.0364e-03-0.2483image
ENSG00000155008.12,APOOLLIHCGemcitabineEAG2.7117e-090.3177image
chrX:85090780-85092047:+LIHCGemcitabineEER2.1527e-090.3196image
chrX:85088057-85089404:+LIHCDasatinibEER1.4734e-02-0.2195image
chrX:85090780-85092047:+LUADBMS.509744EER7.8774e-09-0.2542image
ENSG00000155008.12,APOOLLUADBMS.509744EAG2.0535e-09-0.2637image
ENSG00000155008.12,APOOLLUSCCGP.60474EAG2.9667e-07-0.2318image
chrX:85090780-85092047:+LUSCCGP.60474EER2.8928e-07-0.2320image
chrX:85088057-85089404:+LUSCCisplatinEER4.4578e-03-0.2645image
ENSG00000155008.12,APOOLMESOCisplatinEAG1.9936e-04-0.4092image
chrX:85090780-85092047:+MESOCisplatinEER2.1290e-04-0.4075image
chrX:85090780-85092047:+OVEmbelinEER1.2490e-110.3891image
chrX:85088057-85089404:+OVCCT007093EER1.0586e-030.2441image
ENSG00000155008.12,APOOLOVEmbelinEAG1.2425e-120.4063image
chrX:85090780-85092047:+PAADBIBW2992EER7.0105e-03-0.2055image
ENSG00000155008.12,APOOLPAADBIBW2992EAG5.7192e-03-0.2105image
chrX:85090780-85092047:+PCPGAZD6482EER2.8855e-080.4142image
ENSG00000155008.12,APOOLPCPGAZD6482EAG2.9163e-080.4141image
ENSG00000155008.12,APOOLPRADEmbelinEAG2.3174e-110.2995image
chrX:85090780-85092047:+PRADEmbelinEER1.7797e-110.3011image
chrX:85088057-85089404:+PRADAZD.0530EER3.2186e-03-0.2375image
chrX:85090780-85092047:+READBortezomibEER8.0691e-04-0.3415image
ENSG00000155008.12,APOOLREADCyclopamineEAG9.5139e-04-0.3389image
chrX:85088057-85089404:+SARCFH535EER2.0632e-02-0.3954image
chrX:85090780-85092047:+SARCCisplatinEER4.0129e-09-0.3757image
ENSG00000155008.12,APOOLSARCCisplatinEAG4.6502e-09-0.3742image
ENSG00000155008.12,APOOLSKCMCI.1040EAG1.6715e-09-0.2844image
chrX:85090780-85092047:+SKCMCI.1040EER1.0282e-09-0.2880image
chrX:85088057-85089404:+SKCMMidostaurinEER4.1779e-03-0.2619image
chrX:85088057-85089404:+STADElesclomolEER1.4491e-05-0.2417image
chrX:85090780-85092047:+STADCI.1040EER3.2892e-09-0.3054image
ENSG00000155008.12,APOOLSTADCI.1040EAG3.1961e-09-0.3044image
chrX:85090780-85092047:+TGCTBMS.754807EER3.3944e-080.4610image
ENSG00000155008.12,APOOLTGCTBMS.754807EAG3.3769e-080.4611image
chrX:85090780-85092047:+THCACI.1040EER3.1417e-33-0.5083image
ENSG00000155008.12,APOOLTHCACI.1040EAG1.4083e-33-0.5107image
chrX:85090780-85092047:+THYMEmbelinEER3.1034e-040.3862image
ENSG00000155008.12,APOOLTHYMEmbelinEAG4.1193e-040.3789image
chrX:85090780-85092047:+UCECCGP.60474EER1.0358e-03-0.2744image
ENSG00000155008.12,APOOLUCECCGP.60474EAG1.8504e-03-0.2600image
chrX:85090780-85092047:+UCSABT.888EER2.4880e-04-0.5203image
ENSG00000155008.12,APOOLUCSABT.888EAG2.4813e-04-0.5204image
ENSG00000155008.12,APOOLUVMCGP.60474EAG1.3688e-03-0.4106image
chrX:85090780-85092047:+UVMCGP.60474EER1.2497e-03-0.4136image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType