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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: CPM (ImmuneEditome ID:1368)

1. Gene summary of enriched editing regions for CPM

check button Gene summary
Gene informationGene symbol

CPM

Gene ID

1368

GeneSynonyms-
GeneCytomap

12q15

GeneTypeprotein-coding
GeneDescriptioncarboxypeptidase M|renal carboxypeptidase|urinary carboxypeptidase B
GeneModificationdate20230329
UniprotIDP14384;F8VR29;F8W111;F8VU13;F8VVI6;H0YHG6
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr12:68851291-68852883:-ENST00000338356.6ENSG00000135678.10CPMUTR3AluSc8,AluSx1,MIRcchr12:68851291-68852883:-.alignment
chr12:68851291-68852883:-ENST00000551568.4ENSG00000135678.10CPMUTR3AluSc8,AluSx1,MIRcchr12:68851291-68852883:-.alignment
chr12:68855827-68856063:-ENST00000338356.6ENSG00000135678.10CPMUTR3AluSx1chr12:68855827-68856063:-.alignment
chr12:68855827-68856063:-ENST00000546373.4ENSG00000135678.10CPMUTR3AluSx1chr12:68855827-68856063:-.alignment
chr12:68855827-68856063:-ENST00000546556.1ENSG00000135678.10CPMUTR3AluSx1chr12:68855827-68856063:-.alignment
chr12:68855827-68856063:-ENST00000551568.4ENSG00000135678.10CPMUTR3AluSx1chr12:68855827-68856063:-.alignment
chr12:68878973-68879174:-ENST00000547924.1ENSG00000135678.10CPMncRNA_intronicAluJr4chr12:68878973-68879174:-.alignment
chr12:68897649-68898008:-ENST00000547924.1ENSG00000135678.10CPMncRNA_intronicAluSx3,AluJbchr12:68897649-68898008:-.alignment
chr12:68920720-68921023:-ENST00000547924.1ENSG00000135678.10CPMncRNA_intronicAluSz6chr12:68920720-68921023:-.alignment
chr12:68930160-68930349:-ENST00000547924.1ENSG00000135678.10CPMncRNA_intronicAluSq2chr12:68930160-68930349:-.alignment


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2. Tumor-specific enriched editing regions for CPM


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr12:68851291-68852883:-BRCAEER2.9581e-07image
ENSG00000135678.10,CPMBRCAEAG1.6492e-05image
chr12:68851291-68852883:-KIRCEER6.5894e-04image
ENSG00000135678.10,CPMKIRCEAG3.4326e-03image
chr12:68851291-68852883:-KIRPEER8.6059e-06image
ENSG00000135678.10,CPMKIRPEAG1.8099e-05image
chr12:68851291-68852883:-LUADEER1.6953e-19image
ENSG00000135678.10,CPMLUADEAG2.5690e-19image
chr12:68851291-68852883:-LUSCEER4.8906e-28image
ENSG00000135678.10,CPMLUSCEAG4.3784e-26image
chr12:68851291-68852883:-STADEER4.5692e-04image
ENSG00000135678.10,CPMSTADEAG5.8112e-06image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000135678.10,CPMKIRCPathEAG1.4871e-021.4028e-030.1511image
chr12:68851291-68852883:-KIRCPathEER1.1512e-021.0847e-030.1551image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for CPM


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for CPM


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000135678.10,CPM
ESCAEAGA5ENSG00000175634.10chr1167433339:67433447:67433125:67433257:67433125:674331940.15992.6871e-026.9043e-060.4431imageNACIN1;AUH;BCCIP;CNBP;CPSF6;CSTF2T;DDX3X;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;GNL3;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28A;LIN28B;MOV10;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;RBM22;RBM27;SAFB2;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;ZNF184NANK_cells_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
ENSG00000135678.10,CPM
ESCAEAGA3ENSG00000177697.13chr11838179:838367:838450:838522:838444:8385220.23884.1033e-022.6870e-060.4012imageNACIN1;ADAR;AUH;BCCIP;CNBP;CPSF6;CSTF2T;DDX3X;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;GNL3;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP7;LIN28;LIN28A;LIN28B;MBNL2;MOV10;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;RBM22;RBM27;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;ZNF184CD151Dendritic_cells_activatedGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSE
ENSG00000135678.10,CPM
ESCAEAGIRENSG00000175634.10chr1167433125:67433257:67433339:67433447-0.17121.2515e-021.8024e-06-0.4525imageNACIN1;AUH;BCCIP;CNBP;CPSF6;CSTF2T;DDX3X;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;GNL3;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28A;LIN28B;MOV10;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;RBM22;RBM27;SAFB2;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;ZNF184NAGSVA_HALLMARK_P53_PATHWAY
chr12:68851291-68852883:-
ESCAEERIRENSG00000175634.10chr1167433125:67433257:67433339:67433447-0.16442.2892e-022.0829e-05-0.4098imageNNNAGSVA_HALLMARK_P53_PATHWAY

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5. Enriched editing regions and immune infiltration for CPM


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr12:68851291-68852883:-ACCEEREosinophils1.1213e-060.5655image
ENSG00000135678.10,CPMACCEAGEosinophils9.3420e-070.5689image
chr12:68851291-68852883:-BLCAEERT_cells_CD4_memory_activated7.2600e-050.3202image
ENSG00000135678.10,CPMBLCAEAGT_cells_CD4_memory_activated9.4131e-050.3154image
chr12:68851291-68852883:-BRCAEERT_cells_regulatory_(Tregs)2.3510e-020.1083image
ENSG00000135678.10,CPMBRCAEAGT_cells_regulatory_(Tregs)2.0994e-020.1070image
chr12:68851291-68852883:-CESCEERMacrophages_M13.4728e-030.2297image
ENSG00000135678.10,CPMCESCEAGMacrophages_M12.2911e-030.2387image
chr12:68851291-68852883:-COADEERT_cells_regulatory_(Tregs)2.0078e-020.3710image
ENSG00000135678.10,CPMCOADEAGDendritic_cells_activated3.5342e-020.3146image
chr12:68851291-68852883:-DLBCEERB_cells_memory1.6749e-020.4264image
ENSG00000135678.10,CPMDLBCEAGB_cells_memory1.6749e-020.4264image
chr12:68851291-68852883:-ESCAEERDendritic_cells_activated4.4609e-020.1758image
chr12:68851291-68852883:-GBMEERT_cells_CD4_memory_resting1.5752e-020.2386image
ENSG00000135678.10,CPMGBMEAGT_cells_CD4_memory_resting1.7922e-020.2329image
ENSG00000135678.10,CPMHNSCEAGDendritic_cells_resting4.8755e-020.1687image
chr12:68851291-68852883:-KICHEERT_cells_gamma_delta9.3320e-030.5297image
ENSG00000135678.10,CPMKICHEAGT_cells_gamma_delta6.8439e-030.5368image
chr12:68851291-68852883:-KIRCEERT_cells_regulatory_(Tregs)5.6637e-070.2745image
ENSG00000135678.10,CPMKIRCEAGT_cells_regulatory_(Tregs)1.9331e-060.2605image
chr12:68851291-68852883:-KIRPEERDendritic_cells_activated2.8909e-020.1414image
ENSG00000135678.10,CPMKIRPEAGDendritic_cells_activated2.0259e-020.1501image
chr12:68851291-68852883:-LGGEEREosinophils4.4577e-030.1869image
ENSG00000135678.10,CPMLGGEAGT_cells_regulatory_(Tregs)3.9703e-030.1864image
chr12:68851291-68852883:-LIHCEERT_cells_regulatory_(Tregs)4.4269e-02-0.1160image
ENSG00000135678.10,CPMLIHCEAGT_cells_regulatory_(Tregs)4.5228e-02-0.1153image
chr12:68851291-68852883:-LUADEERT_cells_CD4_memory_resting9.4197e-06-0.2051image
ENSG00000135678.10,CPMLUADEAGMacrophages_M01.8471e-030.1436image
chr12:68851291-68852883:-LUSCEERT_cells_CD4_memory_resting6.3365e-03-0.1995image
ENSG00000135678.10,CPMLUSCEAGT_cells_CD4_memory_resting4.9996e-03-0.2034image
ENSG00000135678.10,CPMPAADEAGB_cells_naive4.6992e-02-0.1795image
chr12:68851291-68852883:-PCPGEERT_cells_gamma_delta6.9020e-030.4424image
ENSG00000135678.10,CPMPCPGEAGDendritic_cells_resting2.8094e-02-0.3611image
chr12:68851291-68852883:-PRADEERT_cells_gamma_delta3.4253e-030.1812image
ENSG00000135678.10,CPMPRADEAGDendritic_cells_activated2.9282e-03-0.1824image
chr12:68851291-68852883:-SARCEERT_cells_CD4_memory_activated2.1084e-020.1999image
ENSG00000135678.10,CPMSARCEAGT_cells_regulatory_(Tregs)2.5474e-020.1923image
chr12:68851291-68852883:-SKCMEERT_cells_CD4_memory_activated8.1250e-040.2349image
ENSG00000135678.10,CPMSKCMEAGT_cells_CD4_memory_activated9.3742e-040.2311image
chr12:68851291-68852883:-STADEERMacrophages_M01.0967e-040.2256image
ENSG00000135678.10,CPMSTADEAGB_cells_naive6.8265e-03-0.1556image
chr12:68851291-68852883:-TGCTEERDendritic_cells_activated3.9720e-030.4167image
ENSG00000135678.10,CPMTGCTEAGDendritic_cells_activated3.9720e-030.4167image
chr12:68851291-68852883:-THCAEERT_cells_regulatory_(Tregs)1.9933e-020.1348image
ENSG00000135678.10,CPMTHCAEAGT_cells_regulatory_(Tregs)1.7687e-020.1355image
chr12:68851291-68852883:-THYMEERDendritic_cells_activated1.3441e-030.6054image
ENSG00000135678.10,CPMTHYMEAGDendritic_cells_activated1.3441e-030.6054image
chr12:68851291-68852883:-UCECEERDendritic_cells_resting1.8155e-03-0.3052image
ENSG00000135678.10,CPMUCECEAGDendritic_cells_resting9.7766e-04-0.3187image


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6. Enriched editing regions and immune gene sets for CPM


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr12:68851291-68852883:-BLCAEER5.4444e-03image4.4821e-030.2324image
ENSG00000135678.10,CPMBLCAEAG2.0925e-03image1.6349e-030.2567image
chr12:68851291-68852883:-LUSCEER4.9637e-03image1.6667e-02-0.1754image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr12:68851291-68852883:-BLCAEER1.1700e-060.38711.1696e-030.26433.0090e-060.37311.4521e-030.2594image
ENSG00000135678.10,CPMBLCAEAG4.3386e-070.40121.1107e-020.20823.4658e-060.37094.0638e-040.2870image
chr12:68851291-68852883:-LUADEER1.3055e-130.33651.9130e-070.24022.0887e-120.32022.9014e-070.2367image
ENSG00000135678.10,CPMLUADEAG2.3903e-110.30231.6831e-060.21925.2729e-110.29735.7379e-050.1849image
chr12:68851291-68852883:-STADEER7.0015e-070.28694.1062e-070.29269.0847e-060.25789.4612e-030.1524image
ENSG00000135678.10,CPMSTADEAG2.0463e-040.21255.1043e-040.19915.3838e-030.16003.7913e-020.1197image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000135678.10,CPMACCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG8.9608e-040.4052image
chr12:68851291-68852883:-ACCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.0647e-030.3998image
ENSG00000135678.10,CPMBLCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.4570e-050.3481image
chr12:68851291-68852883:-BLCAGSVA_HALLMARK_GLYCOLYSISEER9.9303e-060.3544image
ENSG00000135678.10,CPMBRCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG7.0131e-04-0.1566image
chr12:68851291-68852883:-BRCAGSVA_HALLMARK_P53_PATHWAYEER2.0485e-030.1471image
ENSG00000135678.10,CPMCESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2214e-060.3715image
chr12:68851291-68852883:-CESCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER2.7720e-060.3608image
ENSG00000135678.10,CPMCOADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.7535e-02-0.3526image
ENSG00000135678.10,CPMESCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.5842e-030.2509image
chr12:68855827-68856063:-ESCAGSVA_HALLMARK_MYC_TARGETS_V2EER2.9731e-020.4637image
chr12:68851291-68852883:-ESCAGSVA_HALLMARK_MITOTIC_SPINDLEEER1.5583e-030.2737image
ENSG00000135678.10,CPMHNSCGSVA_HALLMARK_SPERMATOGENESISEAG5.2293e-03-0.2373image
chr12:68851291-68852883:-HNSCGSVA_HALLMARK_MTORC1_SIGNALINGEER9.7685e-03-0.2250image
ENSG00000135678.10,CPMKIRCGSVA_HALLMARK_MYC_TARGETS_V2EAG9.1387e-060.2433image
chr12:68851291-68852883:-KIRCGSVA_HALLMARK_MYC_TARGETS_V2EER1.2659e-050.2406image
ENSG00000135678.10,CPMKIRPGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG3.2009e-02-0.1388image
chr12:68851291-68852883:-KIRPGSVA_HALLMARK_TGF_BETA_SIGNALINGEER2.8480e-02-0.1417image
ENSG00000135678.10,CPMLGGGSVA_HALLMARK_KRAS_SIGNALING_UPEAG6.3276e-03-0.1769image
chr12:68851291-68852883:-LGGGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER1.5095e-03-0.2080image
ENSG00000135678.10,CPMLIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG5.9114e-050.2290image
chr12:68851291-68852883:-LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEER9.5239e-050.2230image
ENSG00000135678.10,CPMLUADGSVA_HALLMARK_GLYCOLYSISEAG1.3347e-090.2756image
chr12:68851291-68852883:-LUADGSVA_HALLMARK_GLYCOLYSISEER9.0124e-150.3512image
ENSG00000135678.10,CPMLUSCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.6532e-03-0.2274image
chr12:68851291-68852883:-LUSCGSVA_HALLMARK_COAGULATIONEER2.9402e-05-0.3012image
chr12:68851291-68852883:-PAADGSVA_HALLMARK_SPERMATOGENESISEER1.0453e-02-0.2301image
ENSG00000135678.10,CPMPAADGSVA_HALLMARK_SPERMATOGENESISEAG1.2305e-02-0.2251image
chr12:68851291-68852883:-PCPGGSVA_HALLMARK_BILE_ACID_METABOLISMEER3.2033e-040.5661image
ENSG00000135678.10,CPMPCPGGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.5102e-030.5030image
ENSG00000135678.10,CPMPRADGSVA_HALLMARK_PROTEIN_SECRETIONEAG9.0132e-03-0.1604image
chr12:68851291-68852883:-PRADGSVA_HALLMARK_PROTEIN_SECRETIONEER4.9259e-05-0.2494image
chr12:68851291-68852883:-SARCGSVA_HALLMARK_DNA_REPAIREER9.5810e-050.3318image
ENSG00000135678.10,CPMSARCGSVA_HALLMARK_DNA_REPAIREAG5.2067e-050.3409image
ENSG00000135678.10,CPMSKCMGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.5660e-050.2988image
chr12:68851291-68852883:-SKCMGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER2.6569e-050.2924image
ENSG00000135678.10,CPMSTADGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.6971e-070.2959image
chr12:68851291-68852883:-STADGSVA_HALLMARK_MTORC1_SIGNALINGEER1.7222e-100.3641image
chr12:68851291-68852883:-TGCTGSVA_HALLMARK_DNA_REPAIREER1.6066e-030.4522image
ENSG00000135678.10,CPMTGCTGSVA_HALLMARK_DNA_REPAIREAG1.6066e-030.4522image
chr12:68851291-68852883:-THCAGSVA_HALLMARK_HYPOXIAEER7.7661e-040.1937image
ENSG00000135678.10,CPMTHCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG6.9389e-040.1929image
ENSG00000135678.10,CPMUCECGSVA_HALLMARK_BILE_ACID_METABOLISMEAG4.8329e-03-0.2743image
chr12:68851291-68852883:-UCECGSVA_HALLMARK_UV_RESPONSE_UPEER5.4788e-030.2731image


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7. Enriched editing regions and drugs for CPM


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr12:68851291-68852883:-ACCBI.D1870EER1.6916e-03-0.3848image
ENSG00000135678.10,CPMACCBI.D1870EAG1.9381e-03-0.3803image
chr12:68851291-68852883:-BLCAAUY922EER3.4894e-06-0.3708image
ENSG00000135678.10,CPMBLCAAUY922EAG6.7827e-08-0.4259image
ENSG00000135678.10,CPMBRCAAZD.2281EAG1.4106e-02-0.1139image
chr12:68851291-68852883:-BRCAA.443654EER1.4145e-02-0.1173image
chr12:68851291-68852883:-CESCCMKEER3.7564e-04-0.2778image
ENSG00000135678.10,CPMCESCJNK.Inhibitor.VIIIEAG5.7757e-04-0.2684image
ENSG00000135678.10,CPMCOADLFM.A13EAG4.8727e-02-0.2955image
ENSG00000135678.10,CPMDLBCCGP.082996EAG1.5757e-020.4300image
chr12:68851291-68852883:-DLBCCGP.082996EER1.5757e-020.4300image
chr12:68851291-68852883:-ESCAABT.263EER4.3045e-040.3044image
chr12:68855827-68856063:-ESCAElesclomolEER1.5941e-02-0.5074image
ENSG00000135678.10,CPMESCAABT.263EAG3.0786e-030.2558image
ENSG00000135678.10,CPMGBMJNJ.26854165EAG1.5846e-020.2372image
chr12:68851291-68852883:-GBMJNJ.26854165EER1.4972e-030.3104image
ENSG00000135678.10,CPMHNSCMetforminEAG4.8090e-04-0.2943image
chr12:68851291-68852883:-HNSCGW.441756EER1.4992e-030.2747image
ENSG00000135678.10,CPMKICHBosutinibEAG1.4993e-020.4903image
chr12:68851291-68852883:-KICHBosutinibEER1.0198e-020.5244image
chr12:68851291-68852883:-KIRCCCT007093EER6.0066e-090.3170image
ENSG00000135678.10,CPMKIRCCCT007093EAG4.0301e-070.2767image
chr12:68851291-68852883:-KIRPCyclopamineEER3.4044e-02-0.1372image
ENSG00000135678.10,CPMKIRPCCT007093EAG2.4667e-020.1453image
chr12:68851291-68852883:-LGGBicalutamideEER2.4516e-040.2396image
ENSG00000135678.10,CPMLGGDocetaxelEAG8.1721e-04-0.2160image
chr12:68851291-68852883:-LIHCGSK.650394EER7.0262e-050.2271image
ENSG00000135678.10,CPMLIHCGSK.650394EAG4.7066e-050.2320image
ENSG00000135678.10,CPMLUADDocetaxelEAG2.8765e-08-0.2530image
chr12:68851291-68852883:-LUADDocetaxelEER1.0172e-10-0.2958image
ENSG00000135678.10,CPMLUSCBI.2536EAG4.0152e-04-0.2549image
chr12:68851291-68852883:-LUSCBI.2536EER1.2091e-04-0.2782image
ENSG00000135678.10,CPMOVEHT.1864EAG1.6957e-020.1730image
ENSG00000135678.10,CPMPAADCI.1040EAG4.5228e-03-0.2544image
chr12:68851291-68852883:-PAADBMS.708163EER2.2121e-030.2734image
ENSG00000135678.10,CPMPCPGJNJ.26854165EAG8.1300e-05-0.6019image
chr12:68851291-68852883:-PCPGCamptothecinEER6.1798e-050.6168image
ENSG00000135678.10,CPMPRADBicalutamideEAG7.0594e-030.1655image
chr12:68851291-68852883:-PRADKU.55933EER3.4811e-04-0.2206image
ENSG00000135678.10,CPMSARCCyclopamineEAG1.2421e-03-0.2751image
chr12:68851291-68852883:-SARCCyclopamineEER6.8762e-04-0.2907image
chr12:68851291-68852883:-SKCMCCT018159EER1.8177e-03-0.2192image
ENSG00000135678.10,CPMSKCMCCT018159EAG7.0487e-04-0.2364image
chr12:68851291-68852883:-STADGW.441756EER4.0169e-05-0.2391image
ENSG00000135678.10,CPMSTADGW.441756EAG5.5405e-04-0.1979image
chr12:68920720-68921023:-STADBMS.708163EER1.3436e-030.4588image
chr12:68851291-68852883:-TGCTAKT.inhibitor.VIIIEER1.2924e-030.4602image
ENSG00000135678.10,CPMTGCTAKT.inhibitor.VIIIEAG1.2924e-030.4602image
ENSG00000135678.10,CPMTHCAKU.55933EAG4.6063e-03-0.1618image
chr12:68851291-68852883:-THCAKU.55933EER8.5136e-03-0.1524image
ENSG00000135678.10,CPMTHYMMethotrexateEAG1.4434e-03-0.6023image
chr12:68851291-68852883:-THYMMethotrexateEER1.4434e-03-0.6023image
ENSG00000135678.10,CPMUCECCGP.082996EAG2.0919e-03-0.2984image
chr12:68851291-68852883:-UCECA.770041EER1.0728e-07-0.4970image
ENSG00000135678.10,CPMUCSAUY922EAG4.5643e-02-0.4405image
chr12:68851291-68852883:-UCSEHT.1864EER1.0171e-020.5604image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType