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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: COX7B (ImmuneEditome ID:1349)

1. Gene summary of enriched editing regions for COX7B

check button Gene summary
Gene informationGene symbol

COX7B

Gene ID

1349

GeneSynonymsAPLCC|LSDMCA2
GeneCytomap

Xq21.1

GeneTypeprotein-coding
GeneDescriptioncytochrome c oxidase subunit 7B, mitochondrial|cytochrome c oxidase polypeptide VIIb|cytochrome c oxidase subunit VIIb|cytochrome-c oxidase chain VIIb
GeneModificationdate20230329
UniprotIDP24311;A0A3B3ISY5;A0A3B3ITX0;A0A3B3IRN8
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chrX:77901701-77902047:+ENST00000373335.3ENSG00000131174.4COX7BncRNA_exonicAluJr,L2cchrX:77901701-77902047:+.alignment
chrX:77903275-77904540:+ENST00000373335.3ENSG00000131174.4COX7BncRNA_intronicAluY,AluSx1,(TTTTATA)n,CR1-3_CrocchrX:77903275-77904540:+.alignment


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2. Tumor-specific enriched editing regions for COX7B


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chrX:77901701-77902047:+BRCAEER4.5057e-04image
ENSG00000131174.4,COX7BBRCAEAG1.1654e-03image
chrX:77901701-77902047:+COADEER1.5250e-02image
ENSG00000131174.4,COX7BCOADEAG3.2826e-02image
chrX:77901701-77902047:+KICHEER1.9395e-03image
ENSG00000131174.4,COX7BKICHEAG8.4535e-04image
ENSG00000131174.4,COX7BKIRCEAG1.8952e-02image
chrX:77901701-77902047:+LIHCEER3.3470e-02image
ENSG00000131174.4,COX7BLIHCEAG2.2012e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chrX:77901701-77902047:+SKCMPathEER2.9014e-024.7254e-03-0.1976image
ENSG00000131174.4,COX7BSKCMPathEAG4.9356e-026.4827e-03-0.1877image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for COX7B


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for COX7B


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000131174.4,COX7B
GBMEAGIRENSG00000108846.11chr1750676277:50677943:50678092:50678102-0.35591.0592e-037.7120e-08-0.4616imageNACIN1;AUH;BUD13;CSTF2T;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;LIN28A;LIN28B;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;TAF15;TARBP2;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1NAT_cells_follicular_helperGSVA_HALLMARK_ADIPOGENESIS
chrX:77901701-77902047:+
THYMEERIRENSG00000122965.6chr12113822056:113822608:113823208:113823321-0.24974.1692e-021.1014e-04-0.4006imageNNNADendritic_cells_activatedGSVA_HALLMARK_NOTCH_SIGNALING
chrX:77901701-77902047:+
THYMEERA3ENSG00000122965.6chr12113823208:113823321:113822056:113822608:113822056:1138226460.25553.0530e-023.4256e-050.4358imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_NOTCH_SIGNALING
ENSG00000131174.4,COX7B
THYMEAGIRENSG00000142541.12chr1949489848:49489912:49490231:494902970.46023.1876e-034.5196e-050.4183imageNACIN1;AUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YWHAG;ZNF184NAMast_cells_restingGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chrX:77901701-77902047:+
THYMEERA3ENSG00000140104.9chr14104988942:104989088:104991490:104991620:104989631:104991620-0.37498.3130e-035.3520e-05-0.4545imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PEROXISOME
ENSG00000131174.4,COX7B
THYMEAGA5ENSG00000140104.9chr14104991490:104991620:104988942:104989088:104988942:104989707-0.36162.5397e-021.2519e-04-0.4208imageNACIN1;AUH;BUD13;CNBP;CSTF2T;DDX3X;DDX54;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;HNRNPA2B1;HNRNPC;HNRNPK;IGF2BP1;IGF2BP2;IGF2BP3;LARP4B;LIN28;LIN28B;MOV10;NOP56;NOP58;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SF3A3;SMNDC1;SRSF1;TAF15;TNRC6A;TROVE2;U2AF2;UPF1;ZNF184NADendritic_cells_restingGSVA_HALLMARK_MTORC1_SIGNALING
ENSG00000131174.4,COX7B
THYMEAGESENSG00000148832.10chr10133388955:133389068:133389589:133389747:133391311:133391624-0.33314.3132e-021.7113e-04-0.4034imageNBUD13;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;GTF2F1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP2;KHDRBS1;LIN28;LSM11;NONO;NOP58;NUMA1;PRPF8;PTBP1;RBFOX2;RBM10;RBM22;RBM27;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;TAF15;TARDBP;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZNF184NAGSVA_HALLMARK_MYC_TARGETS_V2
chrX:77901701-77902047:+
THYMEERIRENSG00000131591.13chr11081817:1084383:1084480:1084506-0.40879.1819e-031.3055e-05-0.4611imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
ENSG00000131174.4,COX7B
THYMEAGMEXENSG00000104529.13chr8143590017:143590081:143590607:143590729:143592714:143592893:143597347:1435974150.34492.5436e-022.1118e-040.4180imageNACIN1;AUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YWHAG;ZNF184NAT_cells_gamma_deltaGSVA_HALLMARK_NOTCH_SIGNALING
chrX:77901701-77902047:+
THYMEERESENSG00000140104.9chr14104988942:104989088:104989631:104989707:104991490:1049916200.36291.2391e-026.5434e-050.4498imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PEROXISOME

More results



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5. Enriched editing regions and immune infiltration for COX7B


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000131174.4,COX7BBLCAEAGT_cells_CD4_memory_activated2.7415e-030.2290image
chrX:77901701-77902047:+BRCAEERT_cells_CD4_memory_activated5.0442e-03-0.0943image
ENSG00000131174.4,COX7BBRCAEAGT_cells_CD4_memory_activated1.4176e-02-0.0821image
chrX:77901701-77902047:+CESCEERDendritic_cells_resting1.5834e-02-0.1786image
ENSG00000131174.4,COX7BCESCEAGPlasma_cells3.9544e-020.1515image
chrX:77901701-77902047:+COADEERMast_cells_resting2.5147e-030.2434image
ENSG00000131174.4,COX7BCOADEAGMast_cells_resting4.5519e-020.1614image
chrX:77901701-77902047:+ESCAEERDendritic_cells_resting2.0224e-02-0.1934image
ENSG00000131174.4,COX7BESCAEAGDendritic_cells_resting2.2415e-02-0.1902image
chrX:77901701-77902047:+GBMEERT_cells_regulatory_(Tregs)4.5456e-020.1625image
ENSG00000131174.4,COX7BHNSCEAGNK_cells_activated4.8045e-020.1724image
chrX:77901701-77902047:+KICHEERT_cells_gamma_delta4.2457e-020.2565image
chrX:77901701-77902047:+KIRPEERT_cells_CD4_memory_activated9.7037e-030.1740image
ENSG00000131174.4,COX7BKIRPEAGT_cells_CD4_memory_activated3.4013e-030.1915image
ENSG00000131174.4,COX7BLAMLEAGMacrophages_M22.4926e-02-0.2918image
chrX:77901701-77902047:+LGGEERNK_cells_resting1.7041e-030.1414image
ENSG00000131174.4,COX7BLGGEAGNK_cells_resting1.0911e-020.1148image
chrX:77901701-77902047:+LUADEERT_cells_CD4_memory_resting2.8195e-020.1284image
chrX:77903275-77904540:+LUADEERMacrophages_M12.2264e-02-0.4551image
ENSG00000131174.4,COX7BLUADEAGT_cells_CD4_memory_resting3.4267e-020.1225image
chrX:77901701-77902047:+LUSCEERNeutrophils1.7219e-02-0.1299image
ENSG00000131174.4,COX7BLUSCEAGNeutrophils2.4953e-02-0.1218image
chrX:77901701-77902047:+MESOEERB_cells_naive4.1890e-020.3233image
ENSG00000131174.4,COX7BMESOEAGB_cells_naive4.2190e-020.3228image
chrX:77901701-77902047:+OVEERT_cells_gamma_delta7.1638e-050.2367image
chrX:77903275-77904540:+OVEERT_cells_CD4_memory_resting9.5967e-04-0.5481image
ENSG00000131174.4,COX7BOVEAGT_cells_gamma_delta4.1870e-050.2440image
ENSG00000131174.4,COX7BPAADEAGB_cells_memory3.6026e-02-0.2030image
chrX:77901701-77902047:+PRADEERB_cells_memory2.6119e-02-0.1236image
ENSG00000131174.4,COX7BPRADEAGB_cells_memory3.1270e-02-0.1188image
chrX:77901701-77902047:+SARCEERMacrophages_M17.4511e-030.2245image
ENSG00000131174.4,COX7BSARCEAGMacrophages_M18.3891e-030.2204image
chrX:77901701-77902047:+SKCMEERMacrophages_M17.8917e-030.1736image
ENSG00000131174.4,COX7BSKCMEAGMacrophages_M13.4651e-020.1367image
ENSG00000131174.4,COX7BTGCTEAGNK_cells_resting1.4042e-020.3237image
chrX:77901701-77902047:+THCAEEREosinophils1.6880e-03-0.1445image
ENSG00000131174.4,COX7BTHCAEAGEosinophils2.0883e-03-0.1415image
chrX:77901701-77902047:+THYMEERT_cells_CD4_memory_activated3.5437e-020.2233image
ENSG00000131174.4,COX7BTHYMEAGT_cells_CD4_memory_activated3.3468e-020.2257image
ENSG00000131174.4,COX7BUCECEAGT_cells_CD4_memory_resting1.9646e-02-0.2416image
ENSG00000131174.4,COX7BUCSEAGT_cells_regulatory_(Tregs)2.8208e-020.4075image
chrX:77901701-77902047:+UVMEERT_cells_CD4_naive3.0705e-020.3887image
ENSG00000131174.4,COX7BUVMEAGT_cells_CD4_naive4.8653e-020.3513image


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6. Enriched editing regions and immune gene sets for COX7B


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chrX:77901701-77902047:+ACCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER4.4525e-020.3278image
ENSG00000131174.4,COX7BBLCAGSVA_HALLMARK_COMPLEMENTEAG2.7412e-040.2765image
chrX:77901701-77902047:+BRCAGSVA_HALLMARK_MTORC1_SIGNALINGEER3.5571e-03-0.0980image
ENSG00000131174.4,COX7BBRCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG5.3467e-030.0932image
chrX:77901701-77902047:+COADGSVA_HALLMARK_PANCREAS_BETA_CELLSEER7.4833e-040.2706image
ENSG00000131174.4,COX7BCOADGSVA_HALLMARK_KRAS_SIGNALING_DNEAG5.6767e-040.2746image
ENSG00000131174.4,COX7BGBMGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG1.2553e-020.2020image
chrX:77903275-77904540:+GBMGSVA_HALLMARK_COMPLEMENTEER1.1066e-040.6386image
ENSG00000131174.4,COX7BHNSCGSVA_HALLMARK_MYOGENESISEAG7.7142e-03-0.2310image
chrX:77901701-77902047:+KICHGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER4.6237e-020.2521image
ENSG00000131174.4,COX7BKICHGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.4725e-020.3036image
chrX:77901701-77902047:+KIRCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER4.5357e-02-0.1130image
ENSG00000131174.4,COX7BKIRCGSVA_HALLMARK_APOPTOSISEAG6.8478e-030.1523image
chrX:77901701-77902047:+KIRPGSVA_HALLMARK_KRAS_SIGNALING_DNEER2.5663e-020.1504image
ENSG00000131174.4,COX7BKIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.5154e-050.2728image
ENSG00000131174.4,COX7BLAMLGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.4311e-02-0.3174image
chrX:77901701-77902047:+LGGGSVA_HALLMARK_SPERMATOGENESISEER6.2905e-03-0.1233image
ENSG00000131174.4,COX7BLGGGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG3.3985e-030.1320image
ENSG00000131174.4,COX7BLUADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG2.7926e-02-0.1271image
chrX:77901701-77902047:+LUADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER5.9984e-03-0.1604image
ENSG00000131174.4,COX7BLUSCGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG3.1300e-02-0.1170image
chrX:77901701-77902047:+LUSCGSVA_HALLMARK_P53_PATHWAYEER1.2113e-02-0.1367image
chrX:77901701-77902047:+MESOGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER1.3133e-02-0.3889image
ENSG00000131174.4,COX7BMESOGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.4107e-020.3852image
chrX:77901701-77902047:+OVGSVA_HALLMARK_KRAS_SIGNALING_DNEER2.6412e-030.1803image
ENSG00000131174.4,COX7BOVGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.9902e-030.1853image
chrX:77903275-77904540:+OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER4.2420e-020.3554image
chrX:77901701-77902047:+PCPGGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.3596e-03-0.2403image
ENSG00000131174.4,COX7BPCPGGSVA_HALLMARK_BILE_ACID_METABOLISMEAG6.5675e-03-0.2042image
ENSG00000131174.4,COX7BPRADGSVA_HALLMARK_APICAL_JUNCTIONEAG1.8136e-020.1302image
ENSG00000131174.4,COX7BREADGSVA_HALLMARK_KRAS_SIGNALING_UPEAG2.2281e-020.2854image
ENSG00000131174.4,COX7BSARCGSVA_HALLMARK_MYOGENESISEAG6.4475e-050.3288image
chrX:77901701-77902047:+SARCGSVA_HALLMARK_MYOGENESISEER8.5629e-050.3247image
ENSG00000131174.4,COX7BSKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.6703e-040.2338image
chrX:77901701-77902047:+SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.9374e-040.2351image
chrX:77901701-77902047:+STADGSVA_HALLMARK_DNA_REPAIREER2.0976e-040.2183image
ENSG00000131174.4,COX7BSTADGSVA_HALLMARK_DNA_REPAIREAG8.6708e-050.2304image
ENSG00000131174.4,COX7BTHCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG5.8648e-090.2641image
chrX:77901701-77902047:+THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER1.0972e-070.2419image
chrX:77901701-77902047:+THYMGSVA_HALLMARK_NOTCH_SIGNALINGEER6.9628e-03-0.2842image
ENSG00000131174.4,COX7BTHYMGSVA_HALLMARK_NOTCH_SIGNALINGEAG2.2525e-02-0.2417image
ENSG00000131174.4,COX7BUCECGSVA_HALLMARK_KRAS_SIGNALING_DNEAG3.2841e-020.2215image
ENSG00000131174.4,COX7BUCSGSVA_HALLMARK_SPERMATOGENESISEAG1.2610e-020.4574image


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7. Enriched editing regions and drugs for COX7B


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000131174.4,COX7BACCDocetaxelEAG2.5294e-020.3579image
chrX:77901701-77902047:+ACCCytarabineEER2.5340e-020.3624image
ENSG00000131174.4,COX7BBLCACGP.082996EAG8.4989e-05-0.2976image
chrX:77901701-77902047:+BRCAATRAEER3.4537e-04-0.1203image
ENSG00000131174.4,COX7BBRCAABT.263EAG1.3182e-030.1076image
chrX:77901701-77902047:+CESCMidostaurinEER3.0354e-030.2186image
ENSG00000131174.4,COX7BCESCEpothilone.BEAG3.0754e-030.2165image
chrX:77901701-77902047:+COADGSK.650394EER3.1385e-020.1747image
ENSG00000131174.4,COX7BCOADCMKEAG4.4355e-030.2281image
chrX:77903275-77904540:+GBMEHT.1864EER2.8212e-030.5183image
ENSG00000131174.4,COX7BGBMGW.441756EAG2.4362e-020.1826image
chrX:77901701-77902047:+GBMGefitinibEER2.2649e-02-0.1848image
ENSG00000131174.4,COX7BHNSCDoxorubicinEAG7.0597e-03-0.2335image
ENSG00000131174.4,COX7BKICHAZD7762EAG4.7520e-030.3486image
chrX:77901701-77902047:+KICHGefitinibEER2.6126e-03-0.3729image
chrX:77901701-77902047:+KIRCABT.888EER1.6697e-02-0.1352image
ENSG00000131174.4,COX7BKIRCEHT.1864EAG3.9661e-020.1164image
chrX:77901701-77902047:+KIRPEHT.1864EER1.8293e-020.1590image
ENSG00000131174.4,COX7BKIRPEHT.1864EAG5.4394e-040.2253image
ENSG00000131174.4,COX7BLAMLGDC0941EAG2.2618e-04-0.4625image
ENSG00000131174.4,COX7BLGGJNK.Inhibitor.VIIIEAG7.0672e-030.1214image
chrX:77901701-77902047:+LGGJNJ.26854165EER6.6832e-030.1224image
chrX:77901701-77902047:+LIHCMetforminEER1.2772e-02-0.1489image
ENSG00000131174.4,COX7BLIHCMetforminEAG6.3282e-03-0.1625image
ENSG00000131174.4,COX7BLUADDasatinibEAG3.1209e-030.1721image
chrX:77901701-77902047:+LUADAZD.0530EER1.1648e-040.2236image
ENSG00000131174.4,COX7BLUSCGSK.650394EAG2.8147e-030.1618image
chrX:77901701-77902047:+LUSCA.443654EER1.7511e-030.1701image
ENSG00000131174.4,COX7BOVATRAEAG2.9222e-030.1785image
chrX:77903275-77904540:+OVJNJ.26854165EER1.0232e-030.5456image
chrX:77901701-77902047:+OVATRAEER6.5690e-030.1632image
ENSG00000131174.4,COX7BPAADAUY922EAG1.4787e-020.2351image
chrX:77901701-77902047:+PAADBAY.61.3606EER2.3237e-020.2214image
ENSG00000131174.4,COX7BPCPGAG.014699EAG1.5934e-02-0.1815image
chrX:77901701-77902047:+PCPGAG.014699EER9.8875e-03-0.1945image
chrX:77901701-77902047:+PRADLFM.A13EER3.6283e-02-0.1164image
chrX:77901701-77902047:+SARCCyclopamineEER1.1607e-03-0.2708image
ENSG00000131174.4,COX7BSARCCGP.082996EAG6.0913e-04-0.2842image
ENSG00000131174.4,COX7BSKCMEHT.1864EAG1.2881e-040.2452image
chrX:77901701-77902047:+SKCMEHT.1864EER1.7039e-040.2439image
chrX:77901701-77902047:+STADCCT007093EER2.3789e-020.1341image
ENSG00000131174.4,COX7BSTADCisplatinEAG1.7927e-02-0.1401image
ENSG00000131174.4,COX7BTGCTAMG.706EAG2.8591e-020.2901image
ENSG00000131174.4,COX7BTHCACI.1040EAG5.5652e-08-0.2471image
chrX:77901701-77902047:+THCACI.1040EER2.2446e-07-0.2361image
chrX:77901701-77902047:+THYMLFM.A13EER3.0039e-020.2301image
ENSG00000131174.4,COX7BTHYMLFM.A13EAG3.8098e-020.2202image
ENSG00000131174.4,COX7BUCECA.770041EAG2.1831e-03-0.3139image
chrX:77901701-77902047:+UCECA.770041EER5.1687e-03-0.2908image
ENSG00000131174.4,COX7BUCSCHIR.99021EAG3.1634e-040.6219image
chrX:77901701-77902047:+UVMGDC0941EER1.4312e-020.4356image
ENSG00000131174.4,COX7BUVMGDC0941EAG1.4011e-020.4301image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType