CAeditome Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: IRAK1BP1 (ImmuneEditome ID:134728)

1. Gene summary of enriched editing regions for IRAK1BP1

check button Gene summary
Gene informationGene symbol

IRAK1BP1

Gene ID

134728

GeneSynonymsAIP70|SIMPL
GeneCytomap

6q14.1

GeneTypeprotein-coding
GeneDescriptioninterleukin-1 receptor-associated kinase 1-binding protein 1|ActA binding protein 3|IRAK1-binding protein 1
GeneModificationdate20230329
UniprotIDQ5VVH5;U3KQ34;U3KQ57
PubMed ID

20534545

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr6:78873091-78873740:+ENST00000369940.5ENSG00000146243.12IRAK1BP1intronicAluJr,L1M5,AluSx1chr6:78873091-78873740:+.alignment
chr6:78873091-78873740:+ENST00000606868.4ENSG00000146243.12IRAK1BP1intronicAluJr,L1M5,AluSx1chr6:78873091-78873740:+.alignment
chr6:78873091-78873740:+ENST00000607739.1ENSG00000146243.12IRAK1BP1intronicAluJr,L1M5,AluSx1chr6:78873091-78873740:+.alignment
chr6:78902197-78903490:+ENST00000606868.4ENSG00000146243.12IRAK1BP1exonicAluSz6,AluJr,(TACA)n,AluSzchr6:78902197-78903490:+.alignment
chr6:78902197-78903490:+ENST00000606929.1ENSG00000146243.12IRAK1BP1exonicAluSz6,AluJr,(TACA)n,AluSzchr6:78902197-78903490:+.alignment
chr6:78902197-78903490:+ENST00000607739.1ENSG00000146243.12IRAK1BP1exonicAluSz6,AluJr,(TACA)n,AluSzchr6:78902197-78903490:+.alignment


Top

2. Tumor-specific enriched editing regions for IRAK1BP1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


Top

check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


Top

check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000146243.12,IRAK1BP1LAMLEAG1.2222e-025.7625e-036.1529e+06image

Top

3. Enriched editing regions and immune related genes for IRAK1BP1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr6:78902197-78903490:+THYMEERENSG00000272338,RP11-722E23.2-0.51352.7312e-053.8908e-07-0.5049imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+THYMEERENSG00000276075,CTD-2012K14.8-0.47694.2931e-055.1124e-05-0.4135imageNNNAMacrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+THYMEERENSG00000100288,CHKB-0.47841.7365e-042.9492e-05-0.4252imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+THYMEERENSG00000104918,RETN-0.46761.9358e-043.3141e-05-0.4227imageNNRETNMacrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+THYMEERENSG00000273973,RP11-973D8.5-0.42904.3568e-045.1798e-05-0.4132imageNNNAMacrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+THYMEERENSG00000185324,CDK10-0.43774.7984e-044.9547e-05-0.4141imageNNNAMacrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+THYMEERENSG00000272440,RP11-379F4.6-0.43815.4609e-046.7206e-05-0.4075imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+THYMEERENSG00000197912,SPG7-0.41697.7445e-042.0820e-05-0.4324imageNNNAMacrophages_M1GSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
chr6:78902197-78903490:+THYMEERENSG00000273156,RP11-127B20.2-0.43037.8906e-045.8874e-05-0.4104imageNNNAT_cells_CD4_naiveGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr6:78902197-78903490:+THYMEERENSG00000162148,PPP1R32-0.43437.9264e-041.4553e-05-0.4396imageNNNAMacrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr6:78902197-78903490:+THYMEERENSG00000272338,RP11-722E23.2-0.51352.7312e-053.8908e-07-0.5049imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+THYMEERENSG00000276075,CTD-2012K14.8-0.47694.2931e-055.1124e-05-0.4135imageNNNAMacrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+THYMEERENSG00000100288,CHKB-0.47841.7365e-042.9492e-05-0.4252imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+THYMEERENSG00000104918,RETN-0.46761.9358e-043.3141e-05-0.4227imageNNRETNMacrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+THYMEERENSG00000273973,RP11-973D8.5-0.42904.3568e-045.1798e-05-0.4132imageNNNAMacrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+THYMEERENSG00000185324,CDK10-0.43774.7984e-044.9547e-05-0.4141imageNNNAMacrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+THYMEERENSG00000272440,RP11-379F4.6-0.43815.4609e-046.7206e-05-0.4075imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+THYMEERENSG00000197912,SPG7-0.41697.7445e-042.0820e-05-0.4324imageNNNAMacrophages_M1GSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
chr6:78902197-78903490:+THYMEERENSG00000273156,RP11-127B20.2-0.43037.8906e-045.8874e-05-0.4104imageNNNAT_cells_CD4_naiveGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr6:78902197-78903490:+THYMEERENSG00000162148,PPP1R32-0.43437.9264e-041.4553e-05-0.4396imageNNNAMacrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr6:78902197-78903490:+THYMEERENSG00000272338,RP11-722E23.2-0.51352.7312e-053.8908e-07-0.5049imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+THYMEERENSG00000276075,CTD-2012K14.8-0.47694.2931e-055.1124e-05-0.4135imageNNNAMacrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+THYMEERENSG00000100288,CHKB-0.47841.7365e-042.9492e-05-0.4252imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+THYMEERENSG00000104918,RETN-0.46761.9358e-043.3141e-05-0.4227imageNNRETNMacrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+THYMEERENSG00000273973,RP11-973D8.5-0.42904.3568e-045.1798e-05-0.4132imageNNNAMacrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+THYMEERENSG00000185324,CDK10-0.43774.7984e-044.9547e-05-0.4141imageNNNAMacrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+THYMEERENSG00000272440,RP11-379F4.6-0.43815.4609e-046.7206e-05-0.4075imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+THYMEERENSG00000197912,SPG7-0.41697.7445e-042.0820e-05-0.4324imageNNNAMacrophages_M1GSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
chr6:78902197-78903490:+THYMEERENSG00000273156,RP11-127B20.2-0.43037.8906e-045.8874e-05-0.4104imageNNNAT_cells_CD4_naiveGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr6:78902197-78903490:+THYMEERENSG00000162148,PPP1R32-0.43437.9264e-041.4553e-05-0.4396imageNNNAMacrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY

More results



Top

4. Enriched editing regions and immune related splicing for IRAK1BP1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr6:78902197-78903490:+
THYMEERMEXENSG00000146574.11chr76799194:6799279:6800947:6801044:6806003:6806037:6811951:6812063-0.38262.7692e-025.9467e-05-0.4102imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000146243.12,IRAK1BP1
THYMEAGIRENSG00000165644.6chr1075235059:75235743:75235834:75235925-0.39551.5880e-021.6306e-04-0.4000imageNADAR;CNBP;CPSF6;CSTF2T;DDX54;DGCR8;DHX9;DICER1;EIF4A3;ELAVL1;FBL;FMR1;FTO;FUS;HNRNPC;HNRNPK;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;LARP4B;LIN28B;MOV10;NOP58;PRPF8;PTBP1;RBFOX2;RBM10;SRSF1;SRSF3;TAF15;TARDBP;U2AF1;U2AF2;UPF1NANeutrophilsGSVA_HALLMARK_KRAS_SIGNALING_DN
chr6:78902197-78903490:+
THYMEERMEXENSG00000198034.6chrX72273231:72273389:72273800:72273867:72273867:72273972:72275052:72275150-0.40971.5428e-021.8413e-05-0.4349imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+
THYMEERMEXENSG00000198034.6chrX72273231:72273389:72273800:72273849:72273867:72273972:72275052:72275150-0.40581.6887e-022.3196e-05-0.4302imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000146243.12,IRAK1BP1
THYMEAGMEXENSG00000159352.11chr1151265165:151265234:151265393:151265532:151266003:151266112:151266307:1512664390.39582.1856e-025.9116e-050.4103imageNADAR;CELF2;CNBP;CPSF6;CSTF2T;DDX54;DGCR8;DHX9;DICER1;EIF4A3;ELAVL1;EWSR1;FBL;FMR1;FTO;FUS;HNRNPA1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LIN28A;LIN28B;MOV10;NOP56;NOP58;PRPF8;PTBP1;QKI;RBFOX2;RBM10;SRSF1;SRSF3;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1PSMD4T_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+
THYMEERMEXENSG00000167613.11chr1954355979:54356006:54356229:54356267:54356291:54356398:54356490:54356619-0.38652.6627e-027.8147e-05-0.4041imageNNLAIR1NK_cells_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr6:78902197-78903490:+
THYMEERMEXENSG00000121310.12chr152899176:52899224:52904645:52904833:52906172:52906611:52907867:52907954-0.48331.2625e-031.6782e-07-0.5182imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_HEME_METABOLISM
ENSG00000146243.12,IRAK1BP1
THYMEAGMEXENSG00000198034.6chrX72273231:72273389:72273800:72273867:72273867:72273972:72275052:72275150-0.40971.6464e-021.8413e-05-0.4349imageNADAR;CELF2;CNBP;CPSF6;CSTF2T;DDX54;DGCR8;DHX9;DICER1;EIF4A3;ELAVL1;EWSR1;FBL;FMR1;FTO;FUS;HNRNPA1;HNRNPC;HNRNPD;HNRNPK;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28A;LIN28B;MOV10;NOP56;NOP58;PRPF8;PTBP1;PUM2;QKI;RBFOX2;RBM10;SRSF1;SRSF3;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1;YTHDC1;ZC3H7BNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+
THYMEERMEXENSG00000140988.11chr161962551:1962656:1962735:1962756:1962761:1962909:1963148:1963256-0.39252.2401e-026.9814e-05-0.4066imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr6:78902197-78903490:+
THYMEERMEXENSG00000126934.9chr194095387:4095449:4097278:4097343:4101081:4101143:4101228:4101272-0.39292.3377e-022.7844e-05-0.4264imageNNMAP2K2T_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION

More results



Top

5. Enriched editing regions and immune infiltration for IRAK1BP1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr6:78902197-78903490:+BLCAEERT_cells_CD4_naive2.7072e-020.3096image
ENSG00000146243.12,IRAK1BP1BLCAEAGT_cells_CD4_naive2.7072e-020.3096image
chr6:78902197-78903490:+BRCAEERMast_cells_resting2.4456e-020.1159image
chr6:78902197-78903490:+CESCEERT_cells_CD4_naive3.7734e-030.4645image
ENSG00000146243.12,IRAK1BP1CESCEAGT_cells_CD4_naive1.3323e-020.3980image
chr6:78902197-78903490:+COADEERMacrophages_M24.2197e-020.2775image
ENSG00000146243.12,IRAK1BP1COADEAGMacrophages_M24.0885e-020.2742image
chr6:78902197-78903490:+ESCAEERNK_cells_resting4.5177e-020.2105image
chr6:78902197-78903490:+GBMEERMast_cells_activated6.0676e-030.2726image
ENSG00000146243.12,IRAK1BP1GBMEAGMonocytes3.5112e-020.2069image
chr6:78902197-78903490:+HNSCEERPlasma_cells2.2251e-02-0.4742image
ENSG00000146243.12,IRAK1BP1HNSCEAGPlasma_cells2.5218e-02-0.4654image
ENSG00000146243.12,IRAK1BP1KIRPEAGT_cells_regulatory_(Tregs)4.2814e-02-0.2010image
ENSG00000146243.12,IRAK1BP1LAMLEAGB_cells_naive3.4545e-02-0.4523image
chr6:78902197-78903490:+LGGEERT_cells_CD4_naive2.3306e-02-0.1505image
ENSG00000146243.12,IRAK1BP1LGGEAGT_cells_CD4_naive2.0144e-02-0.1532image
chr6:78902197-78903490:+LUSCEERMacrophages_M02.0630e-02-0.2493image
ENSG00000146243.12,IRAK1BP1LUSCEAGMacrophages_M02.2922e-02-0.2437image
chr6:78902197-78903490:+OVEERMast_cells_activated3.7130e-040.2318image
ENSG00000146243.12,IRAK1BP1OVEAGMast_cells_activated2.9373e-040.2346image
chr6:78902197-78903490:+PCPGEERB_cells_memory1.9681e-020.1878image
ENSG00000146243.12,IRAK1BP1PCPGEAGB_cells_memory1.5098e-020.1955image
chr6:78902197-78903490:+PRADEERB_cells_memory1.3636e-030.2812image
ENSG00000146243.12,IRAK1BP1PRADEAGB_cells_memory9.7744e-040.2859image
chr6:78902197-78903490:+READEERT_cells_CD4_naive4.1642e-02-0.4481image
ENSG00000146243.12,IRAK1BP1READEAGT_cells_CD4_naive4.8439e-02-0.4355image
ENSG00000146243.12,IRAK1BP1SARCEAGPlasma_cells6.0618e-030.3624image
chr6:78902197-78903490:+STADEERB_cells_memory5.2633e-040.2538image
ENSG00000146243.12,IRAK1BP1STADEAGEosinophils9.7472e-03-0.1852image
chr6:78902197-78903490:+TGCTEERNeutrophils3.7701e-030.4706image
ENSG00000146243.12,IRAK1BP1TGCTEAGNeutrophils4.0069e-030.4619image
chr6:78902197-78903490:+THCAEERNK_cells_activated8.0539e-04-0.1696image
ENSG00000146243.12,IRAK1BP1THCAEAGNK_cells_activated6.2191e-04-0.1727image
chr6:78902197-78903490:+THYMEERT_cells_CD4_memory_resting2.1083e-020.2429image
ENSG00000146243.12,IRAK1BP1THYMEAGT_cells_CD4_memory_resting2.1083e-020.2429image
chr6:78902197-78903490:+UCECEERT_cells_CD4_memory_resting3.9596e-02-0.2366image
ENSG00000146243.12,IRAK1BP1UCECEAGT_cells_CD4_memory_resting4.1484e-02-0.2314image
chr6:78902197-78903490:+UCSEERMacrophages_M04.1222e-020.4030image
ENSG00000146243.12,IRAK1BP1UCSEAGMacrophages_M03.7929e-020.4015image


Top

6. Enriched editing regions and immune gene sets for IRAK1BP1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


Top

check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


Top

check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr6:78902197-78903490:+BRCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER2.5078e-030.1552image
ENSG00000146243.12,IRAK1BP1BRCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG3.5236e-030.1482image
chr6:78902197-78903490:+CESCGSVA_HALLMARK_UV_RESPONSE_DNEER3.0256e-020.3566image
chr6:78902197-78903490:+COADGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.1255e-020.3129image
ENSG00000146243.12,IRAK1BP1COADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.4227e-020.3259image
chr6:78902197-78903490:+ESCAGSVA_HALLMARK_TGF_BETA_SIGNALINGEER8.0088e-030.2764image
ENSG00000146243.12,IRAK1BP1ESCAGSVA_HALLMARK_UV_RESPONSE_DNEAG7.5087e-030.2699image
ENSG00000146243.12,IRAK1BP1GBMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG2.1212e-020.2258image
chr6:78902197-78903490:+GBMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER2.2939e-020.2273image
ENSG00000146243.12,IRAK1BP1KIRCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG4.7188e-050.3248image
chr6:78902197-78903490:+KIRCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER1.5859e-050.3456image
ENSG00000146243.12,IRAK1BP1KIRPGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG2.4536e-020.2226image
chr6:78902197-78903490:+KIRPGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.6928e-020.2372image
ENSG00000146243.12,IRAK1BP1LAMLGSVA_HALLMARK_APOPTOSISEAG3.8405e-030.5901image
ENSG00000146243.12,IRAK1BP1LGGGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG4.3001e-040.2303image
chr6:78902197-78903490:+LGGGSVA_HALLMARK_TGF_BETA_SIGNALINGEER2.9234e-040.2382image
chr6:78902197-78903490:+LUADGSVA_HALLMARK_GLYCOLYSISEER1.3325e-02-0.2675image
ENSG00000146243.12,IRAK1BP1LUADGSVA_HALLMARK_GLYCOLYSISEAG1.2568e-02-0.2681image
ENSG00000146243.12,IRAK1BP1LUSCGSVA_HALLMARK_HEME_METABOLISMEAG1.4112e-030.3371image
chr6:78902197-78903490:+LUSCGSVA_HALLMARK_HEME_METABOLISMEER1.8816e-030.3305image
chr6:78902197-78903490:+OVGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER2.2762e-040.2398image
ENSG00000146243.12,IRAK1BP1OVGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG1.6641e-030.2045image
ENSG00000146243.12,IRAK1BP1PAADGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.3456e-030.5668image
chr6:78902197-78903490:+PAADGSVA_HALLMARK_MITOTIC_SPINDLEEER1.3456e-030.5668image
chr6:78902197-78903490:+PCPGGSVA_HALLMARK_APICAL_SURFACEEER5.3381e-030.2235image
ENSG00000146243.12,IRAK1BP1PCPGGSVA_HALLMARK_APICAL_SURFACEEAG5.3434e-030.2234image
chr6:78902197-78903490:+PRADGSVA_HALLMARK_MITOTIC_SPINDLEEER4.0351e-020.1822image
ENSG00000146243.12,IRAK1BP1READGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG2.6469e-020.4833image
chr6:78902197-78903490:+READGSVA_HALLMARK_TGF_BETA_SIGNALINGEER3.3476e-020.4654image
ENSG00000146243.12,IRAK1BP1SARCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG5.9070e-050.5102image
ENSG00000146243.12,IRAK1BP1SKCMGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.4691e-020.3240image
chr6:78902197-78903490:+SKCMGSVA_HALLMARK_MITOTIC_SPINDLEEER2.4691e-020.3240image
ENSG00000146243.12,IRAK1BP1STADGSVA_HALLMARK_KRAS_SIGNALING_DNEAG9.1243e-030.1868image
ENSG00000146243.12,IRAK1BP1TGCTGSVA_HALLMARK_KRAS_SIGNALING_UPEAG1.8374e-030.4951image
chr6:78902197-78903490:+TGCTGSVA_HALLMARK_HEME_METABOLISMEER2.3669e-030.4909image
chr6:78902197-78903490:+THCAGSVA_HALLMARK_MITOTIC_SPINDLEEER1.1619e-060.2442image
ENSG00000146243.12,IRAK1BP1THCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.2505e-060.2371image
ENSG00000146243.12,IRAK1BP1THYMGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.7622e-020.2094image
chr6:78902197-78903490:+THYMGSVA_HALLMARK_PROTEIN_SECRETIONEER4.7622e-020.2094image
ENSG00000146243.12,IRAK1BP1UCECGSVA_HALLMARK_MYC_TARGETS_V2EAG2.3108e-020.2570image
chr6:78902197-78903490:+UCECGSVA_HALLMARK_MYC_TARGETS_V2EER2.6161e-020.2551image


Top

7. Enriched editing regions and drugs for IRAK1BP1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000146243.12,IRAK1BP1BRCALapatinibEAG4.7378e-03-0.1442image
chr6:78902197-78903490:+BRCALapatinibEER2.7931e-03-0.1544image
chr6:78902197-78903490:+CESCBIRB.0796EER2.5143e-020.3677image
ENSG00000146243.12,IRAK1BP1CESCBAY.61.3606EAG6.9195e-030.4309image
ENSG00000146243.12,IRAK1BP1ESCAAP.24534EAG4.5239e-03-0.2859image
chr6:78902197-78903490:+ESCAAP.24534EER1.0353e-02-0.2675image
chr6:78902197-78903490:+GBMGNF.2EER2.0652e-02-0.2312image
ENSG00000146243.12,IRAK1BP1GBMA.770041EAG1.2075e-02-0.2453image
ENSG00000146243.12,IRAK1BP1HNSCCytarabineEAG2.4605e-020.4672image
chr6:78902197-78903490:+HNSCCytarabineEER2.3963e-020.4690image
ENSG00000146243.12,IRAK1BP1KIRCEmbelinEAG1.1562e-03-0.2620image
chr6:78902197-78903490:+KIRCEmbelinEER7.3946e-04-0.2735image
chr6:78902197-78903490:+KIRPAZ628EER3.1869e-030.2907image
ENSG00000146243.12,IRAK1BP1KIRPGDC0941EAG1.5236e-02-0.2397image
ENSG00000146243.12,IRAK1BP1LAMLLenalidomideEAG2.1507e-020.4871image
chr6:78902197-78903490:+LGGDoxorubicinEER1.3013e-03-0.2122image
ENSG00000146243.12,IRAK1BP1LGGDoxorubicinEAG2.7373e-03-0.1967image
ENSG00000146243.12,IRAK1BP1LUADLenalidomideEAG1.2444e-04-0.4021image
chr6:78902197-78903490:+LUADLenalidomideEER1.0927e-04-0.4073image
chr6:78902197-78903490:+LUSCAZD8055EER8.5543e-040.3530image
ENSG00000146243.12,IRAK1BP1LUSCAZD8055EAG5.6964e-040.3620image
chr6:78902197-78903490:+OVAMG.706EER9.8227e-03-0.1692image
ENSG00000146243.12,IRAK1BP1OVAMG.706EAG3.2410e-03-0.1917image
ENSG00000146243.12,IRAK1BP1PCPGCI.1040EAG9.6565e-030.2080image
chr6:78902197-78903490:+PCPGCI.1040EER1.9991e-020.1873image
chr6:78902197-78903490:+PRADFH535EER3.0899e-02-0.1916image
ENSG00000146243.12,IRAK1BP1PRADDMOGEAG4.5902e-02-0.1754image
ENSG00000146243.12,IRAK1BP1SARCCMKEAG1.2103e-030.4216image
chr6:78902197-78903490:+STADCGP.60474EER7.3791e-03-0.1975image
ENSG00000146243.12,IRAK1BP1STADCCT018159EAG4.3359e-03-0.2040image
chr6:78902197-78903490:+TGCTAS601245EER5.6167e-03-0.4523image
ENSG00000146243.12,IRAK1BP1TGCTGDC.0449EAG5.9790e-03-0.4434image
chr6:78902197-78903490:+THCAAMG.706EER3.6702e-060.2328image
ENSG00000146243.12,IRAK1BP1THCAAMG.706EAG1.0582e-050.2213image
ENSG00000146243.12,IRAK1BP1THYMAP.24534EAG4.6349e-030.2959image
chr6:78902197-78903490:+THYMAP.24534EER4.6349e-030.2959image
ENSG00000146243.12,IRAK1BP1UCECBIRB.0796EAG7.3154e-04-0.3745image
chr6:78902197-78903490:+UCECBIRB.0796EER5.3878e-04-0.3877image


Top

check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType