CAeditome Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: SLC25A29 (ImmuneEditome ID:123096)

1. Gene summary of enriched editing regions for SLC25A29

check button Gene summary
Gene informationGene symbol

SLC25A29

Gene ID

123096

GeneSynonymsC14orf69|CACL|ORNT3
GeneCytomap

14q32.2

GeneTypeprotein-coding
GeneDescriptionmitochondrial basic amino acids transporter|carnitine-acylcarnitine translocase like|mitochondrial carnitine/acylcarnitine carrier protein CACL|mitochondrial ornithine transporter 3|solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
GeneModificationdate20230329
UniprotIDQ8N8R3;G3V441;G3V4H8;G3V477;G3V5F4
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr14:100296258-100297094:-ENST00000553359.4ENSG00000197119.11SLC25A29ncRNA_intronicAluY,L1ME3A,AluSx,AluJochr14:100296258-100297094:-.alignment
chr14:100296258-100297094:-ENST00000553574.1ENSG00000197119.11SLC25A29ncRNA_intronicAluY,L1ME3A,AluSx,AluJochr14:100296258-100297094:-.alignment
chr14:100296258-100297094:-ENST00000555051.4ENSG00000197119.11SLC25A29ncRNA_intronicAluY,L1ME3A,AluSx,AluJochr14:100296258-100297094:-.alignment
chr14:100296258-100297094:-ENST00000556873.4ENSG00000197119.11SLC25A29ncRNA_intronicAluY,L1ME3A,AluSx,AluJochr14:100296258-100297094:-.alignment
chr14:100299965-100302676:-ENST00000553359.4ENSG00000197119.11SLC25A29ncRNA_intronicAluSc,L1MD,AluSx,AluJo,L1MEj,AluSz6,AluSx1,AluYm1,AluYj4chr14:100299965-100302676:-.alignment
chr14:100299965-100302676:-ENST00000555949.2ENSG00000197119.11SLC25A29ncRNA_intronicAluSc,L1MD,AluSx,AluJo,L1MEj,AluSz6,AluSx1,AluYm1,AluYj4chr14:100299965-100302676:-.alignment
chr14:100299965-100302676:-ENST00000557438.1ENSG00000197119.11SLC25A29ncRNA_intronicAluSc,L1MD,AluSx,AluJo,L1MEj,AluSz6,AluSx1,AluYm1,AluYj4chr14:100299965-100302676:-.alignment


Top

2. Tumor-specific enriched editing regions for SLC25A29


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000197119.11,SLC25A29KICHEAG9.5341e-03image
chr14:100299965-100302676:-THCAEER3.6820e-13image
ENSG00000197119.11,SLC25A29THCAEAG1.1033e-05image


Top

check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


Top

check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr14:100299965-100302676:-ESCAEER1.8449e-021.1641e-022.3519e+07image

Top

3. Enriched editing regions and immune related genes for SLC25A29


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr14:100296258-100297094:-ESCAEERENSG00000197119,SLC25A29-0.42143.2055e-041.2457e-07-0.4220imageNADAR;ELAVL1;PTBP1NANK_cells_restingGSVA_HALLMARK_MTORC1_SIGNALING
chr14:100296258-100297094:-OVEERENSG00000204392,LSM20.35394.9107e-061.9350e-110.4042imageNADAR;ELAVL1;PTBP1NAT_cells_CD4_memory_restingGSVA_HALLMARK_DNA_REPAIR
chr14:100296258-100297094:-OVEERENSG00000179271,GADD45GIP10.33831.7322e-058.0295e-120.4112imageNADAR;ELAVL1;PTBP1NANK_cells_activatedGSVA_HALLMARK_HEDGEHOG_SIGNALING
chr14:100296258-100297094:-OVEERENSG00000214725,CDIPT-AS10.26481.2308e-035.7541e-150.4632imageNNNAB_cells_memoryGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr14:100296258-100297094:-OVEERENSG00000227507,LTB0.19633.0124e-022.0087e-160.4846imageNNLTBNK_cells_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr14:100296258-100297094:-ESCAEERENSG00000197119,SLC25A29-0.42143.2055e-041.2457e-07-0.4220imageNADAR;ELAVL1;PTBP1NANK_cells_restingGSVA_HALLMARK_MTORC1_SIGNALING
chr14:100296258-100297094:-OVEERENSG00000204392,LSM20.35394.9107e-061.9350e-110.4042imageNADAR;ELAVL1;PTBP1NAT_cells_CD4_memory_restingGSVA_HALLMARK_DNA_REPAIR
chr14:100296258-100297094:-OVEERENSG00000179271,GADD45GIP10.33831.7322e-058.0295e-120.4112imageNADAR;ELAVL1;PTBP1NANK_cells_activatedGSVA_HALLMARK_HEDGEHOG_SIGNALING
chr14:100296258-100297094:-OVEERENSG00000214725,CDIPT-AS10.26481.2308e-035.7541e-150.4632imageNNNAB_cells_memoryGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr14:100296258-100297094:-OVEERENSG00000227507,LTB0.19633.0124e-022.0087e-160.4846imageNNLTBNK_cells_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr14:100296258-100297094:-ESCAEERENSG00000197119,SLC25A29-0.42143.2055e-041.2457e-07-0.4220imageNADAR;ELAVL1;PTBP1NANK_cells_restingGSVA_HALLMARK_MTORC1_SIGNALING
chr14:100296258-100297094:-OVEERENSG00000204392,LSM20.35394.9107e-061.9350e-110.4042imageNADAR;ELAVL1;PTBP1NAT_cells_CD4_memory_restingGSVA_HALLMARK_DNA_REPAIR
chr14:100296258-100297094:-OVEERENSG00000179271,GADD45GIP10.33831.7322e-058.0295e-120.4112imageNADAR;ELAVL1;PTBP1NANK_cells_activatedGSVA_HALLMARK_HEDGEHOG_SIGNALING
chr14:100296258-100297094:-OVEERENSG00000214725,CDIPT-AS10.26481.2308e-035.7541e-150.4632imageNNNAB_cells_memoryGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr14:100296258-100297094:-OVEERENSG00000227507,LTB0.19633.0124e-022.0087e-160.4846imageNNLTBNK_cells_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr14:100296258-100297094:-ESCAEERENSG00000197119,SLC25A29-0.42143.2055e-041.2457e-07-0.4220imageNADAR;ELAVL1;PTBP1NANK_cells_restingGSVA_HALLMARK_MTORC1_SIGNALING
chr14:100296258-100297094:-OVEERENSG00000204392,LSM20.35394.9107e-061.9350e-110.4042imageNADAR;ELAVL1;PTBP1NAT_cells_CD4_memory_restingGSVA_HALLMARK_DNA_REPAIR
chr14:100296258-100297094:-OVEERENSG00000179271,GADD45GIP10.33831.7322e-058.0295e-120.4112imageNADAR;ELAVL1;PTBP1NANK_cells_activatedGSVA_HALLMARK_HEDGEHOG_SIGNALING
chr14:100296258-100297094:-OVEERENSG00000214725,CDIPT-AS10.26481.2308e-035.7541e-150.4632imageNNNAB_cells_memoryGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr14:100296258-100297094:-OVEERENSG00000227507,LTB0.19633.0124e-022.0087e-160.4846imageNNLTBNK_cells_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION

More results



Top

4. Enriched editing regions and immune related splicing for SLC25A29


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr14:100296258-100297094:-
ESCAEERIRENSG00000198668.6chr1490398990:90399087:90400064:90400095-0.35786.7348e-033.2970e-07-0.4410imageNADAR;ELAVL1;PTBP1CALM1T_cells_CD4_memory_restingGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSE
chr14:100296258-100297094:-
ESCAEERIRENSG00000080845.13chr2036496704:36497066:36497446:36497602-0.32313.0413e-025.5727e-07-0.4254imageNADAR;ELAVL1;PTBP1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MTORC1_SIGNALING
ENSG00000197119.11,SLC25A29
ESCAEAGIRENSG00000144354.9chr2173363817:173364161:173364794:173364873-0.30981.5278e-022.2965e-06-0.4331imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YWHAG;ZNF184NAMacrophages_M2GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
ENSG00000197119.11,SLC25A29
ESCAEAGIRENSG00000072210.14chr1719652546:19652632:19656398:19656574-0.22013.4513e-022.5847e-06-0.4190imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;LARP7;LIN28;LIN28B;MBNL2;MOV10;MSI1;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1;ZNF184NAMast_cells_activatedGSVA_HALLMARK_MTORC1_SIGNALING
chr14:100296258-100297094:-
ESCAEERIRENSG00000072210.14chr1719652546:19652632:19656398:19656574-0.21513.8731e-021.7979e-06-0.4266imageNADAR;ELAVL1;PTBP1NAMast_cells_activatedGSVA_HALLMARK_MTORC1_SIGNALING
chr14:100296258-100297094:-
ESCAEERIRENSG00000144354.9chr2173363817:173364161:173364794:173364873-0.30731.5293e-022.5704e-06-0.4312imageNADAR;ELAVL1;PTBP1NAMacrophages_M2GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
ENSG00000197119.11,SLC25A29
TGCTEAGESENSG00000174718.7chr1231970188:31970356:31980877:31985957:31987238:31987322-0.35665.8428e-032.8059e-07-0.4450imageNADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAMacrophages_M2GSVA_HALLMARK_TGF_BETA_SIGNALING
ENSG00000197119.11,SLC25A29
TGCTEAGESENSG00000011426.6chr736415757:36415884:36417079:36417190:36419243:364194670.37921.3960e-034.2133e-060.4060imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SF3A3;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184ANLNMacrophages_M2GSVA_HALLMARK_TGF_BETA_SIGNALING

More results



Top

5. Enriched editing regions and immune infiltration for SLC25A29


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr14:100296258-100297094:-BRCAEERT_cells_CD4_memory_activated1.3231e-040.1378image
ENSG00000197119.11,SLC25A29BRCAEAGT_cells_CD4_memory_activated3.5866e-040.1284image
ENSG00000197119.11,SLC25A29CESCEAGMacrophages_M11.3692e-020.2548image
chr14:100296258-100297094:-ESCAEERMast_cells_activated3.1836e-020.1784image
ENSG00000197119.11,SLC25A29ESCAEAGMast_cells_activated1.5608e-020.1998image
ENSG00000197119.11,SLC25A29HNSCEAGT_cells_gamma_delta4.2247e-030.4717image
ENSG00000197119.11,SLC25A29KICHEAGT_cells_CD4_memory_resting4.3024e-020.4454image
chr14:100296258-100297094:-KIRCEERNK_cells_resting4.7946e-02-0.1738image
ENSG00000197119.11,SLC25A29KIRCEAGEosinophils1.7463e-020.2066image
chr14:100296258-100297094:-KIRPEERT_cells_CD4_naive2.7736e-020.1961image
ENSG00000197119.11,SLC25A29KIRPEAGNK_cells_resting1.2338e-020.2223image
chr14:100296258-100297094:-LAMLEERMacrophages_M27.7995e-040.2911image
chr14:100299965-100302676:-LAMLEERMacrophages_M14.3776e-040.3795image
ENSG00000197119.11,SLC25A29LAMLEAGMacrophages_M29.3332e-030.2206image
chr14:100296258-100297094:-LGGEERMacrophages_M11.1120e-020.1262image
ENSG00000197119.11,SLC25A29LGGEAGT_cells_CD4_memory_resting1.0799e-02-0.1262image
ENSG00000197119.11,SLC25A29LIHCEAGEosinophils4.1115e-050.7597image
chr14:100296258-100297094:-LUADEERMast_cells_resting4.4189e-02-0.1271image
chr14:100299965-100302676:-LUSCEERNK_cells_activated5.9114e-030.5448image
ENSG00000197119.11,SLC25A29LUSCEAGT_cells_follicular_helper1.0999e-020.2031image
chr14:100296258-100297094:-OVEERT_cells_CD81.2488e-020.1562image
chr14:100299965-100302676:-OVEEREosinophils1.6044e-040.2914image
ENSG00000197119.11,SLC25A29OVEAGEosinophils3.2941e-050.2550image
ENSG00000197119.11,SLC25A29PAADEAGMast_cells_resting2.0849e-02-0.2564image
chr14:100296258-100297094:-PCPGEERPlasma_cells1.1980e-020.3637image
ENSG00000197119.11,SLC25A29PCPGEAGPlasma_cells6.4501e-030.3879image
chr14:100296258-100297094:-SKCMEERMacrophages_M12.0141e-020.2276image
ENSG00000197119.11,SLC25A29SKCMEAGMacrophages_M12.0142e-020.2276image
chr14:100296258-100297094:-STADEEREosinophils2.1058e-040.2160image
chr14:100299965-100302676:-STADEERDendritic_cells_resting1.5961e-020.2851image
ENSG00000197119.11,SLC25A29STADEAGEosinophils8.4603e-040.1939image
chr14:100299965-100302676:-TGCTEERT_cells_regulatory_(Tregs)9.2389e-050.3673image
ENSG00000197119.11,SLC25A29TGCTEAGT_cells_regulatory_(Tregs)1.7578e-030.2793image
chr14:100296258-100297094:-THCAEERMonocytes5.3148e-040.1571image
chr14:100299965-100302676:-THCAEERMonocytes1.5945e-03-0.1618image
ENSG00000197119.11,SLC25A29THCAEAGMonocytes4.7320e-030.1275image
chr14:100296258-100297094:-THYMEERNeutrophils8.0090e-030.4038image
ENSG00000197119.11,SLC25A29THYMEAGMacrophages_M23.1984e-030.4443image
chr14:100296258-100297094:-UCECEERPlasma_cells1.4382e-020.2572image
ENSG00000197119.11,SLC25A29UCECEAGT_cells_regulatory_(Tregs)4.4644e-02-0.2076image


Top

6. Enriched editing regions and immune gene sets for SLC25A29


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
ENSG00000197119.11,SLC25A29THCAEAG1.6833e-02image1.4572e-04-0.1709image


Top

check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


Top

check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000197119.11,SLC25A29BLCAGSVA_HALLMARK_KRAS_SIGNALING_DNEAG6.3001e-03-0.3148image
ENSG00000197119.11,SLC25A29BRCAGSVA_HALLMARK_MYC_TARGETS_V1EAG3.6612e-040.1282image
chr14:100299965-100302676:-BRCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.2485e-020.1772image
chr14:100296258-100297094:-BRCAGSVA_HALLMARK_MYC_TARGETS_V1EER1.0833e-040.1396image
ENSG00000197119.11,SLC25A29CESCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG3.7141e-020.2165image
ENSG00000197119.11,SLC25A29COADGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG2.1504e-020.2988image
chr14:100296258-100297094:-ESCAGSVA_HALLMARK_MTORC1_SIGNALINGEER1.1137e-020.2103image
ENSG00000197119.11,SLC25A29ESCAGSVA_HALLMARK_MTORC1_SIGNALINGEAG2.7469e-020.1825image
chr14:100299965-100302676:-ESCAGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER4.4949e-02-0.3038image
ENSG00000197119.11,SLC25A29GBMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG4.1184e-030.2818image
chr14:100296258-100297094:-GBMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER1.8581e-030.3045image
ENSG00000197119.11,SLC25A29KICHGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG2.3113e-020.4931image
ENSG00000197119.11,SLC25A29KIRCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG1.1593e-02-0.2191image
chr14:100296258-100297094:-KIRCGSVA_HALLMARK_MYC_TARGETS_V2EER3.6029e-02-0.1841image
ENSG00000197119.11,SLC25A29KIRPGSVA_HALLMARK_UV_RESPONSE_DNEAG4.5508e-02-0.1785image
chr14:100296258-100297094:-KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEER3.0470e-02-0.1929image
chr14:100299965-100302676:-LAMLGSVA_HALLMARK_PEROXISOMEEER2.1138e-030.3347image
ENSG00000197119.11,SLC25A29LAMLGSVA_HALLMARK_E2F_TARGETSEAG2.5636e-030.2548image
chr14:100296258-100297094:-LAMLGSVA_HALLMARK_E2F_TARGETSEER4.2666e-030.2491image
ENSG00000197119.11,SLC25A29LGGGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.9338e-060.2334image
chr14:100296258-100297094:-LGGGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER3.7596e-080.2695image
ENSG00000197119.11,SLC25A29LUADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.7940e-03-0.1814image
chr14:100296258-100297094:-LUADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER6.9383e-040.2127image
ENSG00000197119.11,SLC25A29LUSCGSVA_HALLMARK_MYOGENESISEAG7.0636e-03-0.2149image
chr14:100299965-100302676:-LUSCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER2.8937e-02-0.4460image
ENSG00000197119.11,SLC25A29OVGSVA_HALLMARK_MYC_TARGETS_V1EAG3.3473e-050.2547image
chr14:100296258-100297094:-OVGSVA_HALLMARK_MYC_TARGETS_V1EER6.1167e-060.2789image
chr14:100296258-100297094:-PCPGGSVA_HALLMARK_KRAS_SIGNALING_DNEER3.4327e-020.3094image
chr14:100299965-100302676:-PRADGSVA_HALLMARK_ADIPOGENESISEER2.3562e-020.3933image
chr14:100296258-100297094:-PRADGSVA_HALLMARK_DNA_REPAIREER3.8972e-020.1246image
ENSG00000197119.11,SLC25A29PRADGSVA_HALLMARK_DNA_REPAIREAG3.1698e-020.1291image
ENSG00000197119.11,SLC25A29SARCGSVA_HALLMARK_APICAL_SURFACEEAG3.3317e-020.2986image
ENSG00000197119.11,SLC25A29SKCMGSVA_HALLMARK_E2F_TARGETSEAG3.9817e-02-0.2019image
chr14:100296258-100297094:-STADGSVA_HALLMARK_MITOTIC_SPINDLEEER3.0359e-02-0.1272image
chr14:100299965-100302676:-STADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.6297e-02-0.2842image
ENSG00000197119.11,SLC25A29STADGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.8985e-02-0.1276image
ENSG00000197119.11,SLC25A29TGCTGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.1467e-040.3408image
chr14:100299965-100302676:-TGCTGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.9679e-050.3982image
chr14:100296258-100297094:-TGCTGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.9467e-020.2322image
ENSG00000197119.11,SLC25A29THCAGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG6.6122e-09-0.2585image
chr14:100299965-100302676:-THCAGSVA_HALLMARK_APOPTOSISEER1.3192e-080.2871image
chr14:100296258-100297094:-THCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.4924e-020.1107image
chr14:100296258-100297094:-THYMGSVA_HALLMARK_HEME_METABOLISMEER1.6691e-02-0.3674image
ENSG00000197119.11,SLC25A29THYMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG2.7790e-02-0.3396image
ENSG00000197119.11,SLC25A29UCECGSVA_HALLMARK_HYPOXIAEAG8.5716e-030.2697image
chr14:100296258-100297094:-UCECGSVA_HALLMARK_HYPOXIAEER9.1532e-030.2733image


Top

7. Enriched editing regions and drugs for SLC25A29


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000197119.11,SLC25A29BLCAAG.014699EAG9.3285e-030.3003image
ENSG00000197119.11,SLC25A29BRCAAZD.2281EAG3.6084e-04-0.1284image
chr14:100296258-100297094:-BRCACyclopamineEER1.7114e-04-0.1358image
ENSG00000197119.11,SLC25A29CESCBMS.708163EAG2.0708e-02-0.2396image
ENSG00000197119.11,SLC25A29COADLapatinibEAG1.3612e-020.3223image
ENSG00000197119.11,SLC25A29ESCACMKEAG6.1215e-04-0.2803image
chr14:100296258-100297094:-ESCADocetaxelEER1.9353e-04-0.3048image
chr14:100299965-100302676:-ESCACisplatinEER2.8533e-030.4393image
ENSG00000197119.11,SLC25A29GBMErlotinibEAG7.4161e-04-0.3288image
chr14:100296258-100297094:-GBMCGP.082996EER6.3144e-04-0.3328image
ENSG00000197119.11,SLC25A29HNSCAKT.inhibitor.VIIIEAG2.0793e-02-0.3893image
ENSG00000197119.11,SLC25A29KICHKIN001.135EAG1.0085e-040.7467image
ENSG00000197119.11,SLC25A29KIRCBI.D1870EAG2.5109e-030.2609image
chr14:100296258-100297094:-KIRCBI.2536EER5.0083e-030.2448image
chr14:100296258-100297094:-KIRPEmbelinEER4.6855e-040.3071image
ENSG00000197119.11,SLC25A29KIRPEmbelinEAG1.4171e-030.2813image
chr14:100296258-100297094:-LAMLEmbelinEER1.5944e-020.2110image
chr14:100299965-100302676:-LAMLCGP.082996EER8.0594e-03-0.2907image
ENSG00000197119.11,SLC25A29LAMLImatinibEAG2.3914e-020.1922image
chr14:100296258-100297094:-LGGAP.24534EER4.5479e-040.1736image
ENSG00000197119.11,SLC25A29LGGAP.24534EAG3.0497e-030.1465image
ENSG00000197119.11,SLC25A29LIHCCGP.082996EAG2.3284e-02-0.4926image
ENSG00000197119.11,SLC25A29LUADMetforminEAG1.6486e-020.1506image
chr14:100299965-100302676:-LUADBMS.536924EER7.2086e-03-0.3910image
chr14:100296258-100297094:-LUADMG.132EER1.6015e-02-0.1519image
chr14:100299965-100302676:-LUSCAZD7762EER1.6019e-020.4861image
ENSG00000197119.11,SLC25A29LUSCBIBW2992EAG1.1335e-02-0.2023image
chr14:100299965-100302676:-OVAZD.2281EER3.8511e-020.1623image
ENSG00000197119.11,SLC25A29OVImatinibEAG7.6005e-070.3016image
chr14:100296258-100297094:-OVImatinibEER1.3806e-080.3461image
ENSG00000197119.11,SLC25A29PCPGDMOGEAG1.1690e-02-0.3611image
chr14:100296258-100297094:-PCPGDMOGEER4.0853e-02-0.2995image
ENSG00000197119.11,SLC25A29PRADCI.1040EAG4.5635e-020.1202image
chr14:100299965-100302676:-PRADBicalutamideEER6.8525e-04-0.5609image
ENSG00000197119.11,SLC25A29SKCMElesclomolEAG2.6626e-04-0.3504image
chr14:100296258-100297094:-SKCMGDC0941EER1.9990e-04-0.3569image
ENSG00000197119.11,SLC25A29STADCI.1040EAG1.1785e-02-0.1470image
chr14:100296258-100297094:-STADCI.1040EER1.7843e-02-0.1390image
chr14:100299965-100302676:-STADEmbelinEER2.1513e-02-0.2725image
chr14:100299965-100302676:-TGCTEmbelinEER1.1020e-030.3098image
ENSG00000197119.11,SLC25A29TGCTAZD8055EAG2.1850e-04-0.3274image
chr14:100296258-100297094:-TGCTBicalutamideEER1.4592e-02-0.2424image
chr14:100296258-100297094:-THCAAZD6482EER4.2186e-080.2462image
ENSG00000197119.11,SLC25A29THCABX.795EAG2.9660e-080.2474image
chr14:100299965-100302676:-THCACGP.60474EER4.0445e-07-0.2571image
ENSG00000197119.11,SLC25A29THYMFTI.277EAG1.2623e-02-0.3817image
chr14:100296258-100297094:-THYMElesclomolEER1.1029e-02-0.3884image
chr14:100296258-100297094:-UCECAKT.inhibitor.VIIIEER5.8565e-030.2883image
ENSG00000197119.11,SLC25A29UCECCCT007093EAG1.0691e-020.2622image


Top

check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType