CAeditome Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: AEBP2 (ImmuneEditome ID:121536)

1. Gene summary of enriched editing regions for AEBP2

check button Gene summary
Gene informationGene symbol

AEBP2

Gene ID

121536

GeneSynonyms-
GeneCytomap

12p12.3

GeneTypeprotein-coding
GeneDescriptionzinc finger protein AEBP2|AE(adipocyte enhancer)-binding protein 2|adipocyte enhancer-binding protein 2
GeneModificationdate20230404
UniprotIDQ6ZN18;G5EA50;H7BYT4;H0YH08;A0A669KBL4;F5GZR7;A0A669KBC9
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr12:19406043-19407248:+ENST00000538425.4ENSG00000139154.13AEBP2intronicAluJo,L1MC1,AluSq2,AluSx1chr12:19406043-19407248:+.alignment
chr12:19406043-19407248:+ENST00000541908.4ENSG00000139154.13AEBP2intronicAluJo,L1MC1,AluSq2,AluSx1chr12:19406043-19407248:+.alignment
chr12:19487414-19487688:+ENST00000266508.12ENSG00000139154.13AEBP2intronicAluSzchr12:19487414-19487688:+.alignment
chr12:19487414-19487688:+ENST00000360995.7ENSG00000139154.13AEBP2intronicAluSzchr12:19487414-19487688:+.alignment
chr12:19487414-19487688:+ENST00000398864.6ENSG00000139154.13AEBP2intronicAluSzchr12:19487414-19487688:+.alignment
chr12:19487414-19487688:+ENST00000538425.4ENSG00000139154.13AEBP2intronicAluSzchr12:19487414-19487688:+.alignment
chr12:19487414-19487688:+ENST00000541908.4ENSG00000139154.13AEBP2intronicAluSzchr12:19487414-19487688:+.alignment
chr12:19554171-19554738:+ENST00000512223.5ENSG00000139154.13AEBP2intronicAluJo,AluSx3chr12:19554171-19554738:+.alignment
chr12:19579085-19579277:+ENST00000512223.5ENSG00000139154.13AEBP2intronicAluSq2chr12:19579085-19579277:+.alignment
chr12:19630275-19630397:+ENST00000512223.5ENSG00000139154.13AEBP2intronicAluJbchr12:19630275-19630397:+.alignment


Top

2. Tumor-specific enriched editing regions for AEBP2


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


Top

check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr12:19554171-19554738:+ESCACliEER1.4553e-024.2479e-03-0.4918image


Top

check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

Top

3. Enriched editing regions and immune related genes for AEBP2


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



Top

4. Enriched editing regions and immune related splicing for AEBP2


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000139154.13,AEBP2
ESCAEAGESENSG00000152457.13chr1014945104:14945189:14945434:14945565:14949035:149490870.30704.4167e-022.0512e-060.4916imageNACIN1;ADAR;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LIN28A;LIN28B;MOV10;MSI1;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184DCLRE1CNeutrophilsGSVA_HALLMARK_ANGIOGENESIS

More results



Top

5. Enriched editing regions and immune infiltration for AEBP2


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000139154.13,AEBP2BLCAEAGT_cells_regulatory_(Tregs)2.6017e-020.3179image
ENSG00000139154.13,AEBP2BRCAEAGT_cells_CD4_memory_resting2.3110e-020.2073image
ENSG00000139154.13,AEBP2CESCEAGMacrophages_M03.5191e-020.2821image
ENSG00000139154.13,AEBP2COADEAGT_cells_follicular_helper5.4659e-050.6772image
ENSG00000139154.13,AEBP2ESCAEAGT_cells_CD4_naive2.1058e-020.2140image
ENSG00000139154.13,AEBP2HNSCEAGT_cells_CD4_naive1.9809e-020.3163image
chr12:19554171-19554738:+KIRCEERT_cells_regulatory_(Tregs)3.2558e-030.5042image
ENSG00000139154.13,AEBP2KIRCEAGT_cells_follicular_helper1.9601e-020.3676image
ENSG00000139154.13,AEBP2LIHCEAGMacrophages_M09.3738e-030.5295image
chr12:19554171-19554738:+LUADEERT_cells_follicular_helper1.6149e-020.4760image
chr12:19554171-19554738:+OVEERMacrophages_M22.8826e-020.2057image
ENSG00000139154.13,AEBP2OVEAGMacrophages_M24.0129e-020.1803image
ENSG00000139154.13,AEBP2PRADEAGT_cells_CD4_memory_resting3.3381e-02-0.3330image
ENSG00000139154.13,AEBP2SKCMEAGT_cells_follicular_helper2.3899e-020.3924image
chr12:19487414-19487688:+STADEERNK_cells_activated2.3530e-030.4621image
chr12:19554171-19554738:+STADEERMacrophages_M21.0302e-020.1867image
ENSG00000139154.13,AEBP2STADEAGMacrophages_M12.4874e-020.1482image


Top

6. Enriched editing regions and immune gene sets for AEBP2


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


Top

check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


Top

check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000139154.13,AEBP2BLCAGSVA_HALLMARK_MYC_TARGETS_V2EAG3.0554e-020.3093image
chr12:19554171-19554738:+BLCAGSVA_HALLMARK_FATTY_ACID_METABOLISMEER2.1993e-020.3860image
ENSG00000139154.13,AEBP2BRCAGSVA_HALLMARK_GLYCOLYSISEAG1.7525e-02-0.2165image
ENSG00000139154.13,AEBP2CESCGSVA_HALLMARK_KRAS_SIGNALING_UPEAG3.7835e-020.2783image
chr12:19554171-19554738:+CESCGSVA_HALLMARK_COMPLEMENTEER4.2417e-020.2973image
ENSG00000139154.13,AEBP2COADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.8674e-020.4340image
ENSG00000139154.13,AEBP2ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2276e-020.2318image
chr12:19554171-19554738:+ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER9.4180e-030.2585image
ENSG00000139154.13,AEBP2HNSCGSVA_HALLMARK_ANGIOGENESISEAG2.9730e-02-0.2961image
ENSG00000139154.13,AEBP2KIRCGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.5851e-02-0.3791image
ENSG00000139154.13,AEBP2LUSCGSVA_HALLMARK_E2F_TARGETSEAG2.1085e-02-0.2456image
chr12:19554171-19554738:+LUSCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.6935e-020.3098image
chr12:19554171-19554738:+OVGSVA_HALLMARK_MYOGENESISEER3.1656e-020.2023image
ENSG00000139154.13,AEBP2SKCMGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.0871e-02-0.3579image
chr12:19554171-19554738:+STADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.3429e-050.3032image
ENSG00000139154.13,AEBP2STADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG5.3565e-030.1835image
chr12:19487414-19487688:+STADGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.6534e-020.3723image
chr12:19554171-19554738:+THCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER3.2858e-020.3054image


Top

7. Enriched editing regions and drugs for AEBP2


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000139154.13,AEBP2BLCAGDC.0449EAG3.4701e-02-0.3024image
chr12:19554171-19554738:+BLCACamptothecinEER1.9575e-02-0.3928image
ENSG00000139154.13,AEBP2BRCABI.D1870EAG1.3568e-020.2248image
ENSG00000139154.13,AEBP2CESCAZD.0530EAG2.7233e-02-0.2951image
chr12:19554171-19554738:+CESCBexaroteneEER1.1833e-02-0.3642image
ENSG00000139154.13,AEBP2COADGDC.0449EAG2.6043e-02-0.4128image
ENSG00000139154.13,AEBP2ESCADocetaxelEAG6.2430e-030.2525image
chr12:19554171-19554738:+ESCACI.1040EER1.1215e-02-0.2526image
ENSG00000139154.13,AEBP2HNSCBX.795EAG9.1573e-030.3515image
ENSG00000139154.13,AEBP2KIRCGSK.650394EAG1.6077e-040.5620image
chr12:19554171-19554738:+KIRCAUY922EER1.5888e-020.4229image
ENSG00000139154.13,AEBP2LIHCAZD6482EAG4.4342e-030.5710image
chr12:19554171-19554738:+LUADGDC0941EER1.4601e-020.4824image
ENSG00000139154.13,AEBP2LUADBosutinibEAG4.6791e-020.3290image
ENSG00000139154.13,AEBP2LUSCEtoposideEAG4.9532e-040.3637image
chr12:19554171-19554738:+LUSCAMG.706EER1.0765e-020.3542image
ENSG00000139154.13,AEBP2OVDoxorubicinEAG1.6944e-020.2091image
chr12:19554171-19554738:+OVGSK.650394EER1.9428e-020.2196image
ENSG00000139154.13,AEBP2PRADBMS.509744EAG5.4549e-03-0.4262image
ENSG00000139154.13,AEBP2SKCMCMKEAG2.0775e-020.4009image
chr12:19554171-19554738:+STADDocetaxelEER1.4560e-03-0.2306image
ENSG00000139154.13,AEBP2STADBryostatin.1EAG4.6415e-03-0.1864image
chr12:19554171-19554738:+THCAImatinibEER1.0234e-030.4549image
ENSG00000139154.13,AEBP2THCAImatinibEAG1.6787e-040.4602image


Top

check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType