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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: DNAJC24 (ImmuneEditome ID:120526)

1. Gene summary of enriched editing regions for DNAJC24

check button Gene summary
Gene informationGene symbol

DNAJC24

Gene ID

120526

GeneSynonymsDPH4|JJJ3|ZCSL3
GeneCytomap

11p13

GeneTypeprotein-coding
GeneDescriptiondnaJ homolog subfamily C member 24|1700030A21Rik|CSL-type zinc finger-containing protein 3|DPH4 homolog (JJJ3, S. cerevisiae)|DPH4, JJJ3 homolog|DnaJ (Hsp40) homolog, subfamily C, member 24|diphthamide biosynthesis protein 4|zinc finger, CSL domain containing 3|zinc finger, CSL-type containing 3
GeneModificationdate20230329
UniprotIDQ6P3W2;E9PRW3;E9PID3
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr11:31430976-31431853:+ENST00000465995.4ENSG00000170946.13DNAJC24UTR3AluSx1,AluSx,AluSzchr11:31430976-31431853:+.alignment


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2. Tumor-specific enriched editing regions for DNAJC24


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr11:31430976-31431853:+BRCAEER3.4416e-03image
ENSG00000170946.13,DNAJC24BRCAEAG3.5119e-03image
chr11:31430976-31431853:+KICHEER6.2975e-03image
ENSG00000170946.13,DNAJC24KICHEAG6.2975e-03image
chr11:31430976-31431853:+KIRPEER3.3593e-04image
ENSG00000170946.13,DNAJC24KIRPEAG3.3593e-04image
chr11:31430976-31431853:+LUSCEER4.1044e-02image
ENSG00000170946.13,DNAJC24LUSCEAG4.1044e-02image
chr11:31430976-31431853:+PRADEER2.9392e-09image
ENSG00000170946.13,DNAJC24PRADEAG2.9392e-09image
chr11:31430976-31431853:+THCAEER1.4118e-05image
ENSG00000170946.13,DNAJC24THCAEAG1.4118e-05image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000170946.13,DNAJC24HNSCPathEAG3.3461e-025.3623e-030.1465image
chr11:31430976-31431853:+HNSCPathEER3.3461e-025.3623e-030.1465image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr11:31430976-31431853:+SARCEER1.1376e-021.3269e-021.7055e+01image
ENSG00000170946.13,DNAJC24SARCEAG1.1376e-021.3269e-021.7055e+01image

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3. Enriched editing regions and immune related genes for DNAJC24


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr11:31430976-31431853:+LGGEERENSG00000170946,DNAJC24-0.36518.9788e-151.2587e-21-0.4017imageNELAVL1;FBL;HNRNPC;KHSRP;TIAL1;U2AF2NAMonocytesGSVA_HALLMARK_MYOGENESIS
chr11:31430976-31431853:+LGGEERENSG00000257704,INAFM10.23342.3746e-061.2446e-240.4281imageNELAVL1;FBL;U2AF2NAMacrophages_M2GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr11:31430976-31431853:+GBMEERENSG00000227939,RPL3P20.36243.8643e-047.2507e-090.4314imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_MYC_TARGETS_V1
chr11:31430976-31431853:+GBMEERENSG00000241431,RPL37P60.35137.2069e-044.1195e-080.4112imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr11:31430976-31431853:+GBMEERENSG00000250568,RP11-333E13.20.35657.4138e-042.3487e-160.5822imageNNNAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
chr11:31430976-31431853:+GBMEERENSG00000230383,AC009245.30.35168.8406e-042.7634e-100.4662imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_MYC_TARGETS_V1
chr11:31430976-31431853:+GBMEERENSG00000224094,RPS24P80.33631.3371e-031.0862e-090.4521imageNNNAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr11:31430976-31431853:+GBMEERENSG00000214485,RPL7P10.33691.4733e-032.2892e-130.5306imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_KRAS_SIGNALING_DN
chr11:31430976-31431853:+GBMEERENSG00000213178,RP11-641D5.10.32712.0513e-038.6740e-080.4020imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
chr11:31430976-31431853:+GBMEERENSG00000230207,RPL4P50.32122.6341e-032.6132e-090.4427imageNNNAT_cells_follicular_helperGSVA_HALLMARK_MYC_TARGETS_V1

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4. Enriched editing regions and immune related splicing for DNAJC24


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr11:31430976-31431853:+
ESCAEERMEXENSG00000181666.13chr1937324207:37324265:37324795:37324936:37335168:37335257:37347189:37347196-0.26424.9725e-022.2380e-06-0.4230imageNELAVL1;FBL;HNRNPC;TIAL1;U2AF2NAMast_cells_activatedGSVA_HALLMARK_MYOGENESIS
ENSG00000170946.13,DNAJC24
ESCAEAGIRENSG00000168003.12chr1162882666:62882807:62882907:62882930-0.31858.2781e-033.2763e-06-0.4167imageNACIN1;ADAR;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FTO;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;WTAP;XRN2;YTHDC1;ZC3H7B;ZNF184SLC3A2T_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr11:31430976-31431853:+
ESCAEERIRENSG00000168003.12chr1162882666:62882807:62882907:62882930-0.31787.3086e-033.2560e-06-0.4168imageNELAVL1;FBL;HNRNPC;KHSRP;TIAL1;U2AF2SLC3A2T_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr11:31430976-31431853:+
ESCAEERIRENSG00000128309.12chr2237024191:37024810:37026998:37027053-0.38721.2651e-031.9158e-07-0.4230imageNELAVL1;FBL;HNRNPC;KHSRP;TIAL1;U2AF2NAT_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING
ENSG00000170946.13,DNAJC24
ESCAEAGIRENSG00000128309.12chr2237024191:37024810:37026998:37027053-0.38881.3019e-031.8497e-07-0.4235imageNADAR;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28B;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RNF219;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING
chr11:31430976-31431853:+
ESCAEERIRENSG00000111011.13chr12122518838:122519051:122521384:122521428-0.27762.6085e-021.1719e-08-0.4762imageNELAVL1;FBL;HNRNPC;KHSRP;TIAL1;U2AF2NAMonocytesGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
ENSG00000170946.13,DNAJC24
ESCAEAGIRENSG00000111011.13chr12122518838:122519051:122521384:122521428-0.27902.9590e-021.1675e-08-0.4762imageNACIN1;ADAR;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;RC3H1;RNF219;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;ZC3H7B;ZNF184NAMonocytesGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr11:31430976-31431853:+
PCPGEERA5ENSG00000040933.11chr298559462:98559495:98555552:98555691:98555552:98555808-0.29445.2869e-034.4266e-08-0.4560imageNELAVL1;FBL;HNRNPC;KHSRP;TIAL1;U2AF2NANK_cells_restingGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
ENSG00000170946.13,DNAJC24
PCPGEAGA5ENSG00000040933.11chr298559462:98559495:98555552:98555691:98555552:98555808-0.29444.7695e-034.4266e-08-0.4560imageNADAR;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LIN28;LIN28A;LIN28B;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;RC3H1;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;WTAP;XRN2;YTHDC1;ZC3H7B;ZNF184NANK_cells_restingGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr11:31430976-31431853:+
THYMEERIRENSG00000130699.12chr2062003159:62003274:62003730:620038780.32523.7473e-029.6055e-060.4647imageNELAVL1;FBL;HNRNPC;KHSRP;TIAL1;U2AF2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION

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5. Enriched editing regions and immune infiltration for DNAJC24


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr11:31430976-31431853:+ACCEERMast_cells_resting2.7272e-020.2739image
ENSG00000170946.13,DNAJC24ACCEAGMast_cells_resting2.7272e-020.2739image
chr11:31430976-31431853:+BLCAEERT_cells_CD4_memory_resting4.8534e-03-0.1667image
ENSG00000170946.13,DNAJC24BLCAEAGT_cells_CD4_memory_resting4.8534e-03-0.1667image
chr11:31430976-31431853:+BRCAEERT_cells_CD4_memory_activated1.3194e-030.1003image
ENSG00000170946.13,DNAJC24BRCAEAGT_cells_regulatory_(Tregs)1.3985e-030.0998image
chr11:31430976-31431853:+CHOLEERT_cells_regulatory_(Tregs)2.8931e-02-0.4206image
ENSG00000170946.13,DNAJC24CHOLEAGT_cells_regulatory_(Tregs)2.8931e-02-0.4206image
chr11:31430976-31431853:+COADEEREosinophils1.2888e-020.1603image
ENSG00000170946.13,DNAJC24COADEAGEosinophils1.2888e-020.1603image
chr11:31430976-31431853:+ESCAEERT_cells_regulatory_(Tregs)7.3637e-03-0.2118image
ENSG00000170946.13,DNAJC24ESCAEAGT_cells_regulatory_(Tregs)7.9672e-03-0.2097image
chr11:31430976-31431853:+GBMEERB_cells_naive1.6751e-020.1860image
ENSG00000170946.13,DNAJC24GBMEAGB_cells_naive1.6751e-020.1860image
chr11:31430976-31431853:+KIRCEERMacrophages_M02.8577e-030.1544image
ENSG00000170946.13,DNAJC24KIRCEAGMacrophages_M02.8577e-030.1544image
chr11:31430976-31431853:+KIRPEERMast_cells_resting4.6445e-02-0.1292image
ENSG00000170946.13,DNAJC24KIRPEAGMast_cells_resting4.6445e-02-0.1292image
ENSG00000170946.13,DNAJC24LAMLEAGPlasma_cells1.5700e-020.2763image
chr11:31430976-31431853:+LGGEERNK_cells_activated4.2876e-020.0888image
ENSG00000170946.13,DNAJC24LGGEAGNK_cells_activated4.2876e-020.0888image
chr11:31430976-31431853:+LIHCEERMonocytes2.7872e-030.1910image
ENSG00000170946.13,DNAJC24LIHCEAGMonocytes2.7872e-030.1910image
chr11:31430976-31431853:+LUADEERT_cells_gamma_delta1.9174e-020.1120image
ENSG00000170946.13,DNAJC24LUADEAGT_cells_gamma_delta1.9174e-020.1120image
chr11:31430976-31431853:+LUSCEERNK_cells_resting2.4621e-020.1063image
ENSG00000170946.13,DNAJC24LUSCEAGNK_cells_resting2.4621e-020.1063image
chr11:31430976-31431853:+MESOEERB_cells_naive4.6746e-020.2438image
ENSG00000170946.13,DNAJC24MESOEAGB_cells_naive4.6746e-020.2438image
chr11:31430976-31431853:+PAADEERPlasma_cells3.3742e-02-0.1712image
ENSG00000170946.13,DNAJC24PAADEAGPlasma_cells3.3742e-02-0.1712image
chr11:31430976-31431853:+PRADEERNK_cells_activated6.8015e-030.1310image
ENSG00000170946.13,DNAJC24PRADEAGNK_cells_activated6.8015e-030.1310image
chr11:31430976-31431853:+READEERT_cells_gamma_delta2.4642e-020.2496image
ENSG00000170946.13,DNAJC24READEAGT_cells_gamma_delta2.4642e-020.2496image
chr11:31430976-31431853:+SARCEERMast_cells_resting1.0848e-02-0.1707image
ENSG00000170946.13,DNAJC24SARCEAGMast_cells_resting1.0848e-02-0.1707image
chr11:31430976-31431853:+SKCMEERMast_cells_activated5.4341e-030.1353image
ENSG00000170946.13,DNAJC24SKCMEAGMast_cells_activated5.4341e-030.1353image
chr11:31430976-31431853:+STADEERT_cells_CD4_memory_activated1.6521e-040.2026image
ENSG00000170946.13,DNAJC24STADEAGT_cells_CD4_memory_activated2.0013e-040.1998image
chr11:31430976-31431853:+TGCTEERMast_cells_resting4.6884e-020.1917image
ENSG00000170946.13,DNAJC24TGCTEAGMast_cells_resting4.6884e-020.1917image
chr11:31430976-31431853:+THCAEERDendritic_cells_activated2.1817e-020.1041image
ENSG00000170946.13,DNAJC24THCAEAGDendritic_cells_activated2.1817e-020.1041image
chr11:31430976-31431853:+THYMEERB_cells_memory1.7853e-020.2534image
ENSG00000170946.13,DNAJC24THYMEAGB_cells_memory1.7853e-020.2534image
chr11:31430976-31431853:+UCECEERMacrophages_M13.5676e-030.2630image
ENSG00000170946.13,DNAJC24UCECEAGMacrophages_M13.5676e-030.2630image
chr11:31430976-31431853:+UVMEERMast_cells_activated1.7376e-030.4587image
ENSG00000170946.13,DNAJC24UVMEAGMast_cells_activated1.7376e-030.4587image


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6. Enriched editing regions and immune gene sets for DNAJC24


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr11:31430976-31431853:+BRCAEER2.6977e-080.17284.2771e-040.11003.9746e-030.09001.4691e-030.0994image
ENSG00000170946.13,DNAJC24BRCAEAG3.1536e-080.17204.5535e-040.10954.2162e-030.08941.5549e-030.0989image
chr11:31430976-31431853:+STADEER2.3032e-050.22711.5069e-020.13154.4444e-030.15374.1452e-030.1549image
ENSG00000170946.13,DNAJC24STADEAG2.0639e-050.22801.4215e-020.13254.0867e-030.15493.9857e-030.1553image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000170946.13,DNAJC24ACCGSVA_HALLMARK_G2M_CHECKPOINTEAG8.9321e-03-0.3219image
chr11:31430976-31431853:+ACCGSVA_HALLMARK_G2M_CHECKPOINTEER8.9321e-03-0.3219image
ENSG00000170946.13,DNAJC24BLCAGSVA_HALLMARK_COAGULATIONEAG5.1155e-030.1657image
chr11:31430976-31431853:+BLCAGSVA_HALLMARK_COAGULATIONEER5.1155e-030.1657image
chr11:31430976-31431853:+BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER7.9230e-170.2566image
ENSG00000170946.13,DNAJC24BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.0117e-160.2557image
ENSG00000170946.13,DNAJC24CESCGSVA_HALLMARK_HEME_METABOLISMEAG9.4550e-03-0.1652image
chr11:31430976-31431853:+CESCGSVA_HALLMARK_HEME_METABOLISMEER9.4550e-03-0.1652image
chr11:31430976-31431853:+CHOLGSVA_HALLMARK_NOTCH_SIGNALINGEER6.8058e-030.5082image
ENSG00000170946.13,DNAJC24CHOLGSVA_HALLMARK_NOTCH_SIGNALINGEAG6.8058e-030.5082image
chr11:31430976-31431853:+COADGSVA_HALLMARK_HEME_METABOLISMEER8.4823e-03-0.1696image
ENSG00000170946.13,DNAJC24COADGSVA_HALLMARK_HEME_METABOLISMEAG8.4823e-03-0.1696image
ENSG00000170946.13,DNAJC24DLBCGSVA_HALLMARK_DNA_REPAIREAG4.3434e-020.3712image
chr11:31430976-31431853:+DLBCGSVA_HALLMARK_DNA_REPAIREER4.3434e-020.3712image
ENSG00000170946.13,DNAJC24ESCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG5.7212e-030.2182image
chr11:31430976-31431853:+ESCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER6.0981e-030.2166image
chr11:31430976-31431853:+GBMGSVA_HALLMARK_KRAS_SIGNALING_UPEER1.4370e-020.1903image
ENSG00000170946.13,DNAJC24GBMGSVA_HALLMARK_KRAS_SIGNALING_UPEAG1.4370e-020.1903image
chr11:31430976-31431853:+HNSCGSVA_HALLMARK_MYOGENESISEER1.1458e-02-0.1240image
ENSG00000170946.13,DNAJC24HNSCGSVA_HALLMARK_MYOGENESISEAG1.1458e-02-0.1240image
ENSG00000170946.13,DNAJC24KIRCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.4769e-04-0.1958image
chr11:31430976-31431853:+KIRCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.4769e-04-0.1958image
chr11:31430976-31431853:+KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEER1.9848e-02-0.1509image
ENSG00000170946.13,DNAJC24KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.9848e-02-0.1509image
ENSG00000170946.13,DNAJC24LGGGSVA_HALLMARK_MITOTIC_SPINDLEEAG9.6889e-07-0.2126image
chr11:31430976-31431853:+LGGGSVA_HALLMARK_MITOTIC_SPINDLEEER9.6889e-07-0.2126image
chr11:31430976-31431853:+LIHCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.8085e-03-0.1703image
ENSG00000170946.13,DNAJC24LIHCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.8085e-03-0.1703image
chr11:31430976-31431853:+LUADGSVA_HALLMARK_MYC_TARGETS_V1EER1.7454e-020.1137image
ENSG00000170946.13,DNAJC24LUADGSVA_HALLMARK_MYC_TARGETS_V1EAG1.7454e-020.1137image
chr11:31430976-31431853:+LUSCGSVA_HALLMARK_BILE_ACID_METABOLISMEER7.1433e-03-0.1271image
ENSG00000170946.13,DNAJC24LUSCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG7.1433e-03-0.1271image
chr11:31430976-31431853:+MESOGSVA_HALLMARK_PROTEIN_SECRETIONEER2.7349e-02-0.2696image
ENSG00000170946.13,DNAJC24MESOGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.7349e-02-0.2696image
ENSG00000170946.13,DNAJC24OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.2735e-030.1920image
chr11:31430976-31431853:+OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.0540e-030.1951image
chr11:31430976-31431853:+PAADGSVA_HALLMARK_SPERMATOGENESISEER2.9813e-02-0.1751image
ENSG00000170946.13,DNAJC24PAADGSVA_HALLMARK_SPERMATOGENESISEAG2.9813e-02-0.1751image
ENSG00000170946.13,DNAJC24PCPGGSVA_HALLMARK_SPERMATOGENESISEAG4.1550e-04-0.2733image
chr11:31430976-31431853:+PCPGGSVA_HALLMARK_SPERMATOGENESISEER4.1550e-04-0.2733image
chr11:31430976-31431853:+PRADGSVA_HALLMARK_HEME_METABOLISMEER1.3213e-03-0.1551image
ENSG00000170946.13,DNAJC24PRADGSVA_HALLMARK_HEME_METABOLISMEAG1.3213e-03-0.1551image
ENSG00000170946.13,DNAJC24READGSVA_HALLMARK_HEME_METABOLISMEAG8.9614e-030.2887image
chr11:31430976-31431853:+READGSVA_HALLMARK_HEME_METABOLISMEER8.9614e-030.2887image
ENSG00000170946.13,DNAJC24SARCGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.6450e-030.2101image
chr11:31430976-31431853:+SARCGSVA_HALLMARK_NOTCH_SIGNALINGEER1.6450e-030.2101image
ENSG00000170946.13,DNAJC24SKCMGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.4429e-05-0.2041image
chr11:31430976-31431853:+SKCMGSVA_HALLMARK_MITOTIC_SPINDLEEER2.4429e-05-0.2041image
ENSG00000170946.13,DNAJC24STADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG8.9350e-070.2620image
chr11:31430976-31431853:+STADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER8.8027e-070.2625image
chr11:31430976-31431853:+TGCTGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.3860e-020.2362image
ENSG00000170946.13,DNAJC24TGCTGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.3860e-020.2362image
ENSG00000170946.13,DNAJC24THCAGSVA_HALLMARK_GLYCOLYSISEAG1.2617e-050.1968image
chr11:31430976-31431853:+THCAGSVA_HALLMARK_GLYCOLYSISEER1.2617e-050.1968image
chr11:31430976-31431853:+THYMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.9189e-030.3062image
ENSG00000170946.13,DNAJC24THYMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.9189e-030.3062image
ENSG00000170946.13,DNAJC24UCECGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG2.6031e-030.2714image
chr11:31430976-31431853:+UCECGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER2.6031e-030.2714image


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7. Enriched editing regions and drugs for DNAJC24


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr11:31430976-31431853:+ACCGSK.650394EER4.8088e-020.2462image
ENSG00000170946.13,DNAJC24ACCGSK.650394EAG4.8088e-020.2462image
chr11:31430976-31431853:+BLCACGP.082996EER2.5983e-03-0.1781image
ENSG00000170946.13,DNAJC24BLCACGP.082996EAG2.5983e-03-0.1781image
chr11:31430976-31431853:+BRCACCT007093EER8.5079e-140.2306image
ENSG00000170946.13,DNAJC24BRCACCT007093EAG1.2715e-130.2290image
chr11:31430976-31431853:+CESCAZD.0530EER7.4476e-03-0.1702image
ENSG00000170946.13,DNAJC24CESCAZD.0530EAG7.4476e-03-0.1702image
chr11:31430976-31431853:+CHOLKIN001.135EER2.3204e-02-0.4354image
ENSG00000170946.13,DNAJC24CHOLKIN001.135EAG2.3204e-02-0.4354image
chr11:31430976-31431853:+COADAZ628EER9.6676e-030.1667image
ENSG00000170946.13,DNAJC24COADAZ628EAG9.6676e-030.1667image
chr11:31430976-31431853:+DLBCBX.795EER3.8610e-020.3795image
ENSG00000170946.13,DNAJC24DLBCBX.795EAG3.8610e-020.3795image
chr11:31430976-31431853:+ESCADocetaxelEER1.4875e-03-0.2499image
ENSG00000170946.13,DNAJC24ESCADocetaxelEAG1.5899e-03-0.2484image
chr11:31430976-31431853:+GBMCGP.082996EER4.6313e-04-0.2696image
ENSG00000170946.13,DNAJC24GBMCGP.082996EAG4.6313e-04-0.2696image
chr11:31430976-31431853:+HNSCCisplatinEER1.6490e-02-0.1177image
ENSG00000170946.13,DNAJC24HNSCCisplatinEAG1.6490e-02-0.1177image
ENSG00000170946.13,DNAJC24KICHAG.014699EAG4.5219e-02-0.2493image
chr11:31430976-31431853:+KICHAG.014699EER4.5219e-02-0.2493image
chr11:31430976-31431853:+KIRCBAY.61.3606EER2.6814e-040.1881image
ENSG00000170946.13,DNAJC24KIRCBAY.61.3606EAG2.6814e-040.1881image
chr11:31430976-31431853:+KIRPAZD6482EER2.8982e-030.1923image
ENSG00000170946.13,DNAJC24KIRPAZD6482EAG2.8982e-030.1923image
ENSG00000170946.13,DNAJC24LGGGNF.2EAG6.9378e-11-0.2806image
chr11:31430976-31431853:+LGGGNF.2EER6.9378e-11-0.2806image
chr11:31430976-31431853:+LIHCCamptothecinEER1.1462e-020.1620image
ENSG00000170946.13,DNAJC24LIHCCamptothecinEAG1.1462e-020.1620image
ENSG00000170946.13,DNAJC24LUADGW.441756EAG5.8047e-03-0.1318image
chr11:31430976-31431853:+LUADGW.441756EER5.8047e-03-0.1318image
chr11:31430976-31431853:+LUSCGW.441756EER6.8364e-04-0.1600image
ENSG00000170946.13,DNAJC24LUSCGW.441756EAG6.8364e-04-0.1600image
chr11:31430976-31431853:+MESOJNK.Inhibitor.VIIIEER3.2214e-020.2620image
ENSG00000170946.13,DNAJC24MESOJNK.Inhibitor.VIIIEAG3.2214e-020.2620image
ENSG00000170946.13,DNAJC24OVBMS.536924EAG2.6417e-04-0.2168image
chr11:31430976-31431853:+OVBMS.536924EER3.3726e-04-0.2131image
ENSG00000170946.13,DNAJC24PCPGJNJ.26854165EAG7.7544e-06-0.3423image
chr11:31430976-31431853:+PCPGJNJ.26854165EER7.7544e-06-0.3423image
chr11:31430976-31431853:+PRADAZ628EER2.8405e-04-0.1754image
ENSG00000170946.13,DNAJC24PRADAZ628EAG2.8405e-04-0.1754image
chr11:31430976-31431853:+READImatinibEER2.2724e-020.2529image
ENSG00000170946.13,DNAJC24READImatinibEAG2.2724e-020.2529image
chr11:31430976-31431853:+SARCBMS.708163EER3.6975e-040.2369image
ENSG00000170946.13,DNAJC24SARCBMS.708163EAG3.6975e-040.2369image
ENSG00000170946.13,DNAJC24SKCMBMS.509744EAG8.2775e-04-0.1624image
chr11:31430976-31431853:+SKCMBMS.509744EER8.2775e-04-0.1624image
ENSG00000170946.13,DNAJC24STADCCT007093EAG3.1929e-050.2229image
chr11:31430976-31431853:+STADCCT007093EER3.4558e-050.2223image
ENSG00000170946.13,DNAJC24TGCTAZD.2281EAG4.9244e-030.2687image
chr11:31430976-31431853:+TGCTAZD.2281EER4.9244e-030.2687image
ENSG00000170946.13,DNAJC24THCAEmbelinEAG1.2871e-070.2370image
chr11:31430976-31431853:+THCAEmbelinEER1.2871e-070.2370image
chr11:31430976-31431853:+THYMJW.7.52.1EER1.3286e-04-0.3983image
ENSG00000170946.13,DNAJC24THYMJW.7.52.1EAG1.3286e-04-0.3983image
chr11:31430976-31431853:+UCECGefitinibEER9.9255e-04-0.2957image
ENSG00000170946.13,DNAJC24UCECGefitinibEAG9.9255e-04-0.2957image
ENSG00000170946.13,DNAJC24UCSA.770041EAG4.1672e-03-0.3984image
chr11:31430976-31431853:+UCSA.770041EER4.1672e-03-0.3984image
chr11:31430976-31431853:+UVMA.770041EER2.2776e-02-0.3427image
ENSG00000170946.13,DNAJC24UVMA.770041EAG2.2776e-02-0.3427image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType