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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ANAPC16 (ImmuneEditome ID:119504)

1. Gene summary of enriched editing regions for ANAPC16

check button Gene summary
Gene informationGene symbol

ANAPC16

Gene ID

119504

GeneSynonymsAPC16|C10orf104|CENP-27|MSAG|bA570G20.3
GeneCytomap

10q22.1

GeneTypeprotein-coding
GeneDescriptionanaphase-promoting complex subunit 16|centromere protein 27|cyclosome subunit 16|metabolic syndrome-associated protein
GeneModificationdate20230517
UniprotIDQ96DE5;A0A087WUN5
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr10:72219525-72223358:+ENST00000470481.2ENSG00000166295.7ANAPC16ncRNA_exonicAluSq2,AluSg,L1MB3,HY3,AluJo,AluSx,FLAM_C,AluJb,AluSc,(T)n,AluSx1,AluSp,MER3,A-richchr10:72219525-72223358:+.alignment
chr10:72224387-72226637:+ENST00000470481.2ENSG00000166295.7ANAPC16ncRNA_intronicMamSINE1,AluSx1,MER5A,MIR3,AluSx,AluJo,AluSc,AluJbchr10:72224387-72226637:+.alignment
chr10:72224387-72226637:+ENST00000478193.4ENSG00000166295.7ANAPC16ncRNA_intronicMamSINE1,AluSx1,MER5A,MIR3,AluSx,AluJo,AluSc,AluJbchr10:72224387-72226637:+.alignment
chr10:72233982-72235492:+ENST00000299381.4ENSG00000166295.7ANAPC16UTR3AluSz,AluSq2,AluJr,AluSq,MIR3chr10:72233982-72235492:+.alignment
chr10:72233982-72235492:+ENST00000615507.3ENSG00000166295.7ANAPC16UTR3AluSz,AluSq2,AluJr,AluSq,MIR3chr10:72233982-72235492:+.alignment
chr10:72233982-72235492:+ENST00000621663.3ENSG00000166295.7ANAPC16UTR3AluSz,AluSq2,AluJr,AluSq,MIR3chr10:72233982-72235492:+.alignment


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2. Tumor-specific enriched editing regions for ANAPC16


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr10:72233982-72235492:+BRCAEER4.0777e-24image
ENSG00000166295.7,ANAPC16BRCAEAG3.2148e-18image
chr10:72233982-72235492:+COADEER1.2633e-09image
ENSG00000166295.7,ANAPC16COADEAG4.5511e-07image
chr10:72233982-72235492:+HNSCEER4.2194e-10image
ENSG00000166295.7,ANAPC16HNSCEAG2.9689e-08image
chr10:72233982-72235492:+KIRCEER2.4266e-02image
ENSG00000166295.7,ANAPC16KIRCEAG1.4897e-02image
chr10:72233982-72235492:+LUADEER3.9663e-16image
ENSG00000166295.7,ANAPC16LUADEAG1.1935e-11image
chr10:72233982-72235492:+LUSCEER1.5962e-12image
ENSG00000166295.7,ANAPC16LUSCEAG5.5963e-12image
chr10:72233982-72235492:+UCECEER5.2498e-10image
ENSG00000166295.7,ANAPC16UCECEAG3.6825e-08image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr10:72233982-72235492:+READEER4.1934e-026.9104e-031.5089e+05image

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3. Enriched editing regions and immune related genes for ANAPC16


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr10:72233982-72235492:+COADEERENSG00000144504,ANKMY1-0.20241.8879e-027.9120e-160.4672imageNNNADendritic_cells_activatedGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr10:72233982-72235492:+COADEERENSG00000263050,RP11-667K14.30.19652.6452e-021.0202e-150.4656imageNNNANeutrophilsGSVA_HALLMARK_PEROXISOME
chr10:72233982-72235492:+COADEERENSG00000220205,VAMP20.18304.3916e-026.2969e-200.5212imageNNNADendritic_cells_activatedGSVA_HALLMARK_MYC_TARGETS_V2
chr10:72233982-72235492:+UVMEERENSG00000143314,MRPL240.45802.8915e-032.5152e-040.4215imageNNNAMast_cells_activatedGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr10:72233982-72235492:+UVMEERENSG00000173171,MTX10.44844.5335e-032.1097e-050.4817imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
chr10:72233982-72235492:+UVMEERENSG00000160688,FLAD10.45125.0048e-035.2503e-050.4608imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
chr10:72233982-72235492:+UVMEERENSG00000170906,NDUFA30.43806.7117e-033.0172e-040.4166imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
chr10:72233982-72235492:+UVMEERENSG00000242125,SNHG3-0.42788.4843e-035.3067e-04-0.4009imageNNNAEosinophilsGSVA_HALLMARK_APICAL_SURFACE
chr10:72233982-72235492:+UVMEERENSG00000163382,APOA1BP0.43278.6543e-034.1967e-060.5156imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr10:72233982-72235492:+UVMEERENSG00000125520,SLC2A4RG0.41969.6967e-031.9498e-040.4282imageNNNAMast_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr10:72233982-72235492:+COADEERENSG00000144504,ANKMY1-0.20241.8879e-027.9120e-160.4672imageNNNADendritic_cells_activatedGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr10:72233982-72235492:+COADEERENSG00000263050,RP11-667K14.30.19652.6452e-021.0202e-150.4656imageNNNANeutrophilsGSVA_HALLMARK_PEROXISOME
chr10:72233982-72235492:+COADEERENSG00000220205,VAMP20.18304.3916e-026.2969e-200.5212imageNNNADendritic_cells_activatedGSVA_HALLMARK_MYC_TARGETS_V2
chr10:72233982-72235492:+UVMEERENSG00000143314,MRPL240.45802.8915e-032.5152e-040.4215imageNNNAMast_cells_activatedGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr10:72233982-72235492:+UVMEERENSG00000173171,MTX10.44844.5335e-032.1097e-050.4817imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
chr10:72233982-72235492:+UVMEERENSG00000160688,FLAD10.45125.0048e-035.2503e-050.4608imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
chr10:72233982-72235492:+UVMEERENSG00000170906,NDUFA30.43806.7117e-033.0172e-040.4166imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
chr10:72233982-72235492:+UVMEERENSG00000242125,SNHG3-0.42788.4843e-035.3067e-04-0.4009imageNNNAEosinophilsGSVA_HALLMARK_APICAL_SURFACE
chr10:72233982-72235492:+UVMEERENSG00000163382,APOA1BP0.43278.6543e-034.1967e-060.5156imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr10:72233982-72235492:+UVMEERENSG00000125520,SLC2A4RG0.41969.6967e-031.9498e-040.4282imageNNNAMast_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr10:72233982-72235492:+COADEERENSG00000144504,ANKMY1-0.20241.8879e-027.9120e-160.4672imageNNNADendritic_cells_activatedGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr10:72233982-72235492:+COADEERENSG00000263050,RP11-667K14.30.19652.6452e-021.0202e-150.4656imageNNNANeutrophilsGSVA_HALLMARK_PEROXISOME
chr10:72233982-72235492:+COADEERENSG00000220205,VAMP20.18304.3916e-026.2969e-200.5212imageNNNADendritic_cells_activatedGSVA_HALLMARK_MYC_TARGETS_V2
chr10:72233982-72235492:+UVMEERENSG00000143314,MRPL240.45802.8915e-032.5152e-040.4215imageNNNAMast_cells_activatedGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr10:72233982-72235492:+UVMEERENSG00000173171,MTX10.44844.5335e-032.1097e-050.4817imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
chr10:72233982-72235492:+UVMEERENSG00000160688,FLAD10.45125.0048e-035.2503e-050.4608imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
chr10:72233982-72235492:+UVMEERENSG00000170906,NDUFA30.43806.7117e-033.0172e-040.4166imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
chr10:72233982-72235492:+UVMEERENSG00000242125,SNHG3-0.42788.4843e-035.3067e-04-0.4009imageNNNAEosinophilsGSVA_HALLMARK_APICAL_SURFACE
chr10:72233982-72235492:+UVMEERENSG00000163382,APOA1BP0.43278.6543e-034.1967e-060.5156imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr10:72233982-72235492:+UVMEERENSG00000125520,SLC2A4RG0.41969.6967e-031.9498e-040.4282imageNNNAMast_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION

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4. Enriched editing regions and immune related splicing for ANAPC16


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000166295.7,ANAPC16
COADEAGMEXENSG00000101391.16chr2033374139:33374212:33379460:33379691:33394031:33394066:33395012:33395116-0.22014.8279e-028.2562e-17-0.4802imageNADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RC3H1;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZNF184NANeutrophilsGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr10:72233982-72235492:+
COADEERIRENSG00000005436.9chr275662705:75670284:75671949:756720160.22264.2346e-025.6316e-190.5112imageNNNAEosinophilsGSVA_HALLMARK_DNA_REPAIR
chr10:72233982-72235492:+
COADEERA3ENSG00000221978.7chr11393395:1393439:1390765:1390865:1390765:13928030.23032.7856e-022.5490e-120.4127imageNNNADendritic_cells_activatedGSVA_HALLMARK_ANDROGEN_RESPONSE
chr10:72233982-72235492:+
COADEERMEXENSG00000145495.10chr510394752:10394785:10397292:10397307:10400783:10400842:10402058:10402139-0.24321.6112e-023.1914e-19-0.5126imageNNNADendritic_cells_activatedGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr10:72233982-72235492:+
COADEERMEXENSG00000145495.10chr510394752:10394785:10397292:10397307:10400837:10400842:10402058:10402139-0.24221.6888e-023.2175e-19-0.5125imageNNNADendritic_cells_activatedGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr10:72233982-72235492:+
COADEERMEXENSG00000105373.14chr1947751519:47751590:47752511:47752544:47754562:47754631:47754708:477547570.24171.8954e-021.9972e-160.4757imageNNNAEosinophilsGSVA_HALLMARK_P53_PATHWAY
chr10:72233982-72235492:+
COADEERIRENSG00000058673.11chr1203795653:203796496:203801574:2038016280.23371.1139e-022.7877e-100.4031imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_DNA_REPAIR
ENSG00000166295.7,ANAPC16
TGCTEAGESENSG00000204371.7chr631888598:31888747:31888968:31889070:31889227:31889340-0.39271.7945e-042.0100e-08-0.4583imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CPSF6;CSTF2T;DDX3X;DDX42;DGCR8;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM22;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YWHAG;ZNF184EHMT2T_cells_CD4_memory_activatedGSVA_HALLMARK_MTORC1_SIGNALING
chr10:72233982-72235492:+
TGCTEERESENSG00000139116.13chr1239326263:39326324:39330241:39330262:39330745:39330911-0.30272.7154e-036.2488e-06-0.4212imageNNNAMacrophages_M2GSVA_HALLMARK_MYC_TARGETS_V2
chr10:72233982-72235492:+
TGCTEERIRENSG00000075399.8chr1689711881:89711969:89712046:897120930.33341.5925e-032.3010e-060.4144imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MYC_TARGETS_V2

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5. Enriched editing regions and immune infiltration for ANAPC16


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr10:72233982-72235492:+BLCAEERT_cells_CD4_memory_activated1.6558e-070.2568image
ENSG00000166295.7,ANAPC16BLCAEAGT_cells_CD4_memory_activated1.2222e-060.2384image
chr10:72224387-72226637:+BRCAEERMast_cells_resting2.7907e-020.3080image
chr10:72233982-72235492:+BRCAEERT_cells_CD4_memory_activated6.6680e-040.1035image
ENSG00000166295.7,ANAPC16BRCAEAGT_cells_CD4_memory_activated9.0221e-050.1189image
chr10:72233982-72235492:+CESCEERMacrophages_M12.3423e-020.1302image
ENSG00000166295.7,ANAPC16CESCEAGDendritic_cells_activated1.7736e-020.1361image
chr10:72233982-72235492:+CHOLEERT_cells_CD84.3141e-02-0.3438image
chr10:72233982-72235492:+COADEERDendritic_cells_activated1.6544e-050.2607image
ENSG00000166295.7,ANAPC16COADEAGDendritic_cells_activated7.0320e-030.1640image
chr10:72233982-72235492:+DLBCEERNeutrophils5.0157e-030.3986image
ENSG00000166295.7,ANAPC16DLBCEAGNeutrophils5.5666e-030.3942image
chr10:72219525-72223358:+ESCAEERT_cells_regulatory_(Tregs)8.6872e-030.2164image
chr10:72224387-72226637:+ESCAEERT_cells_regulatory_(Tregs)2.8961e-04-0.3437image
chr10:72233982-72235492:+ESCAEERT_cells_regulatory_(Tregs)9.9031e-04-0.2580image
ENSG00000166295.7,ANAPC16ESCAEAGMast_cells_resting3.5361e-03-0.2286image
chr10:72233982-72235492:+GBMEERDendritic_cells_resting4.1302e-020.1600image
ENSG00000166295.7,ANAPC16GBMEAGMacrophages_M04.8040e-03-0.2185image
chr10:72233982-72235492:+HNSCEERT_cells_regulatory_(Tregs)7.8268e-05-0.1769image
ENSG00000166295.7,ANAPC16HNSCEAGT_cells_regulatory_(Tregs)1.0281e-04-0.1733image
ENSG00000166295.7,ANAPC16KICHEAGNK_cells_activated3.0803e-02-0.2681image
chr10:72233982-72235492:+KIRCEEREosinophils1.7733e-060.2410image
ENSG00000166295.7,ANAPC16KIRCEAGEosinophils2.6642e-060.2366image
chr10:72219525-72223358:+KIRPEERT_cells_CD4_memory_activated2.9105e-040.4384image
chr10:72233982-72235492:+KIRPEERT_cells_follicular_helper2.3304e-040.2152image
ENSG00000166295.7,ANAPC16KIRPEAGT_cells_follicular_helper3.2834e-040.2102image
chr10:72219525-72223358:+LAMLEERMacrophages_M26.7088e-040.3996image
chr10:72233982-72235492:+LAMLEERT_cells_CD4_memory_activated7.6935e-030.2383image
ENSG00000166295.7,ANAPC16LAMLEAGT_cells_CD4_memory_activated1.9823e-020.2057image
chr10:72233982-72235492:+LGGEERMacrophages_M16.4012e-030.1185image
ENSG00000166295.7,ANAPC16LGGEAGT_cells_gamma_delta9.8400e-030.1122image
chr10:72233982-72235492:+LIHCEERMacrophages_M01.3503e-02-0.1280image
ENSG00000166295.7,ANAPC16LIHCEAGMacrophages_M19.7201e-030.1337image
chr10:72233982-72235492:+LUADEERT_cells_CD4_naive4.2183e-04-0.1557image
ENSG00000166295.7,ANAPC16LUADEAGT_cells_CD4_naive5.8157e-04-0.1512image
chr10:72233982-72235492:+LUSCEERT_cells_CD4_memory_activated1.3684e-040.1703image
ENSG00000166295.7,ANAPC16LUSCEAGT_cells_CD4_memory_activated2.1660e-030.1371image
chr10:72233982-72235492:+MESOEERT_cells_CD81.3259e-020.2725image
ENSG00000166295.7,ANAPC16MESOEAGT_cells_CD86.7201e-030.2971image
chr10:72219525-72223358:+OVEERNeutrophils1.4055e-040.2362image
chr10:72233982-72235492:+OVEERT_cells_CD82.6177e-040.2121image
ENSG00000166295.7,ANAPC16OVEAGMacrophages_M13.0543e-030.1728image
chr10:72233982-72235492:+PAADEERMacrophages_M08.9016e-040.2470image
ENSG00000166295.7,ANAPC16PAADEAGMacrophages_M01.6219e-020.1800image
chr10:72233982-72235492:+PCPGEERT_cells_regulatory_(Tregs)5.1604e-040.2542image
ENSG00000166295.7,ANAPC16PCPGEAGT_cells_regulatory_(Tregs)4.1417e-040.2583image
chr10:72233982-72235492:+PRADEERNK_cells_resting5.3379e-050.1798image
ENSG00000166295.7,ANAPC16PRADEAGB_cells_naive9.1227e-040.1480image
chr10:72233982-72235492:+READEERNK_cells_activated3.2696e-02-0.2205image
ENSG00000166295.7,ANAPC16READEAGNK_cells_activated4.1442e-02-0.2108image
chr10:72233982-72235492:+SARCEERT_cells_CD4_naive1.7609e-02-0.1485image
ENSG00000166295.7,ANAPC16SARCEAGT_cells_CD4_naive1.0857e-02-0.1593image
chr10:72233982-72235492:+SKCMEERT_cells_follicular_helper7.1293e-030.1274image
ENSG00000166295.7,ANAPC16SKCMEAGT_cells_follicular_helper4.2492e-030.1338image
chr10:72219525-72223358:+STADEERT_cells_follicular_helper3.8331e-02-0.1197image
chr10:72224387-72226637:+STADEERDendritic_cells_resting2.5712e-030.2285image
chr10:72233982-72235492:+STADEERT_cells_CD4_memory_activated5.4464e-060.2387image
ENSG00000166295.7,ANAPC16STADEAGT_cells_CD4_memory_activated8.1133e-070.2565image
chr10:72233982-72235492:+TGCTEERT_cells_regulatory_(Tregs)1.0256e-04-0.3118image
ENSG00000166295.7,ANAPC16TGCTEAGT_cells_regulatory_(Tregs)2.2683e-04-0.2958image
chr10:72233982-72235492:+THCAEERB_cells_naive2.0179e-040.1648image
ENSG00000166295.7,ANAPC16THCAEAGB_cells_naive4.5733e-040.1555image
chr10:72233982-72235492:+THYMEERMacrophages_M21.6755e-050.3850image
ENSG00000166295.7,ANAPC16THYMEAGMacrophages_M21.2302e-030.2940image
chr10:72233982-72235492:+UCECEERT_cells_regulatory_(Tregs)4.7306e-02-0.1510image
ENSG00000166295.7,ANAPC16UCECEAGDendritic_cells_activated2.4327e-020.1707image


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6. Enriched editing regions and immune gene sets for ANAPC16


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr10:72219525-72223358:+STADEER2.4875e-02image5.3289e-06-0.2593image
ENSG00000166295.7,ANAPC16STADEAG3.2767e-05image9.7575e-03-0.1360image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000166295.7,ANAPC16BLCAEAG2.3795e-100.30805.4155e-070.24591.8417e-070.25561.2258e-040.1897image
chr10:72233982-72235492:+BLCAEER3.0909e-120.33782.8907e-080.27164.1001e-090.28722.7307e-050.2071image
ENSG00000166295.7,ANAPC16HNSCEAG6.6365e-040.15222.0656e-04-0.16572.9359e-040.16187.8007e-050.1763image
chr10:72233982-72235492:+HNSCEER5.8470e-030.12403.9986e-06-0.20602.7989e-030.13445.6674e-060.2028image
ENSG00000166295.7,ANAPC16LIHCEAG1.4072e-02-0.12701.3408e-03-0.16552.1840e-04-0.19031.4401e-020.1266image
chr10:72233982-72235492:+LIHCEER3.0471e-02-0.11222.1057e-03-0.15901.9383e-04-0.19211.1870e-020.1303image
ENSG00000166295.7,ANAPC16LUADEAG2.6644e-070.22461.2050e-050.19171.0543e-080.24902.8323e-050.1835image
chr10:72233982-72235492:+LUADEER1.7423e-070.22911.0066e-060.21482.8452e-080.24294.1133e-050.1807image
chr10:72233982-72235492:+PAADEER3.1373e-030.22024.8600e-040.25882.5877e-030.22452.4482e-030.2257image
chr10:72233982-72235492:+STADEER3.1228e-080.28852.3992e-030.16061.1317e-040.20352.0103e-030.1634image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000166295.7,ANAPC16ACCGSVA_HALLMARK_APICAL_SURFACEEAG2.3637e-02-0.2561image
chr10:72233982-72235492:+ACCGSVA_HALLMARK_APICAL_SURFACEEER2.5152e-02-0.2535image
ENSG00000166295.7,ANAPC16BLCAGSVA_HALLMARK_MTORC1_SIGNALINGEAG6.0700e-120.3330image
chr10:72233982-72235492:+BLCAGSVA_HALLMARK_MTORC1_SIGNALINGEER1.7295e-140.3692image
ENSG00000166295.7,ANAPC16BRCAGSVA_HALLMARK_MTORC1_SIGNALINGEAG4.9949e-100.1878image
chr10:72224387-72226637:+BRCAGSVA_HALLMARK_GLYCOLYSISEER7.6492e-030.3693image
chr10:72219525-72223358:+BRCAGSVA_HALLMARK_GLYCOLYSISEER8.5125e-07-0.2274image
chr10:72233982-72235492:+BRCAGSVA_HALLMARK_MTORC1_SIGNALINGEER8.1940e-120.2063image
chr10:72233982-72235492:+CESCGSVA_HALLMARK_COMPLEMENTEER5.3012e-060.2582image
ENSG00000166295.7,ANAPC16CESCGSVA_HALLMARK_COMPLEMENTEAG5.9250e-060.2569image
ENSG00000166295.7,ANAPC16CHOLGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.1885e-020.4206image
chr10:72233982-72235492:+CHOLGSVA_HALLMARK_MYOGENESISEER2.3859e-02-0.3812image
chr10:72233982-72235492:+COADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER5.0485e-030.1714image
ENSG00000166295.7,ANAPC16COADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG9.6707e-040.2001image
ENSG00000166295.7,ANAPC16DLBCGSVA_HALLMARK_IL2_STAT5_SIGNALINGEAG5.6389e-030.3936image
chr10:72233982-72235492:+DLBCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.2335e-020.3586image
chr10:72233982-72235492:+ESCAGSVA_HALLMARK_MTORC1_SIGNALINGEER3.3777e-030.2304image
ENSG00000166295.7,ANAPC16ESCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG5.3055e-030.2188image
chr10:72224387-72226637:+ESCAGSVA_HALLMARK_MTORC1_SIGNALINGEER2.6874e-040.3454image
chr10:72219525-72223358:+ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER2.8762e-03-0.2450image
chr10:72233982-72235492:+GBMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER4.5288e-02-0.1570image
chr10:72233982-72235492:+HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.2860e-120.3030image
ENSG00000166295.7,ANAPC16HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.2692e-100.2795image
ENSG00000166295.7,ANAPC16KICHGSVA_HALLMARK_G2M_CHECKPOINTEAG5.5953e-060.5301image
chr10:72233982-72235492:+KICHGSVA_HALLMARK_G2M_CHECKPOINTEER5.6733e-050.4779image
ENSG00000166295.7,ANAPC16KIRCGSVA_HALLMARK_ANDROGEN_RESPONSEEAG7.8886e-050.1998image
chr10:72219525-72223358:+KIRCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER9.2507e-06-0.3766image
chr10:72233982-72235492:+KIRCGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.0483e-050.2228image
chr10:72233982-72235492:+KIRPGSVA_HALLMARK_MTORC1_SIGNALINGEER4.0676e-030.1688image
ENSG00000166295.7,ANAPC16KIRPGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.0540e-020.1505image
chr10:72219525-72223358:+KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEER4.7151e-02-0.2491image
ENSG00000166295.7,ANAPC16LAMLGSVA_HALLMARK_DNA_REPAIREAG2.4969e-03-0.2651image
chr10:72233982-72235492:+LAMLGSVA_HALLMARK_ANDROGEN_RESPONSEEER6.4218e-030.2435image
chr10:72219525-72223358:+LAMLGSVA_HALLMARK_ANDROGEN_RESPONSEEER2.3930e-03-0.3598image
ENSG00000166295.7,ANAPC16LGGGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.7945e-090.2580image
chr10:72233982-72235492:+LGGGSVA_HALLMARK_ANDROGEN_RESPONSEEER2.1663e-110.2859image
ENSG00000166295.7,ANAPC16LIHCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.9952e-090.3042image
chr10:72233982-72235492:+LIHCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER2.0968e-090.3042image
ENSG00000166295.7,ANAPC16LUADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG6.0963e-110.2833image
chr10:72233982-72235492:+LUADGSVA_HALLMARK_GLYCOLYSISEER1.3065e-100.2798image
ENSG00000166295.7,ANAPC16LUSCGSVA_HALLMARK_UV_RESPONSE_UPEAG2.2646e-030.1365image
chr10:72233982-72235492:+LUSCGSVA_HALLMARK_UV_RESPONSE_UPEER7.0819e-040.1514image
chr10:72233982-72235492:+MESOGSVA_HALLMARK_COMPLEMENTEER5.4115e-060.4786image
ENSG00000166295.7,ANAPC16MESOGSVA_HALLMARK_COMPLEMENTEAG6.3664e-060.4754image
chr10:72224387-72226637:+OVGSVA_HALLMARK_PROTEIN_SECRETIONEER2.6611e-020.3305image
chr10:72233982-72235492:+OVGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.0565e-110.3841image
ENSG00000166295.7,ANAPC16OVGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG7.5509e-110.3690image
chr10:72219525-72223358:+OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.4418e-05-0.2680image
chr10:72233982-72235492:+PAADGSVA_HALLMARK_GLYCOLYSISEER1.4655e-040.2808image
ENSG00000166295.7,ANAPC16PAADGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.0643e-030.2433image
ENSG00000166295.7,ANAPC16PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.5091e-050.3139image
chr10:72233982-72235492:+PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.5735e-050.3133image
ENSG00000166295.7,ANAPC16PRADGSVA_HALLMARK_MITOTIC_SPINDLEEAG9.7575e-100.2693image
chr10:72233982-72235492:+PRADGSVA_HALLMARK_MITOTIC_SPINDLEEER1.4175e-100.2820image
chr10:72233982-72235492:+SARCGSVA_HALLMARK_PROTEIN_SECRETIONEER2.3479e-020.1418image
ENSG00000166295.7,ANAPC16SKCMGSVA_HALLMARK_DNA_REPAIREAG3.9354e-050.1915image
chr10:72233982-72235492:+SKCMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER7.3108e-060.2108image
chr10:72233982-72235492:+STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.7304e-090.3090image
chr10:72219525-72223358:+STADGSVA_HALLMARK_APICAL_JUNCTIONEER4.2039e-07-0.2871image
ENSG00000166295.7,ANAPC16STADGSVA_HALLMARK_MYC_TARGETS_V1EAG1.1398e-060.2531image
chr10:72224387-72226637:+STADGSVA_HALLMARK_NOTCH_SIGNALINGEER1.4242e-040.2861image
chr10:72233982-72235492:+TGCTGSVA_HALLMARK_MYC_TARGETS_V2EER1.7936e-070.4107image
ENSG00000166295.7,ANAPC16TGCTGSVA_HALLMARK_MYC_TARGETS_V2EAG3.5064e-060.3673image
chr10:72219525-72223358:+THCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER8.9916e-06-0.3594image
chr10:72233982-72235492:+THCAGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.4508e-100.2805image
ENSG00000166295.7,ANAPC16THCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.0964e-090.2672image
ENSG00000166295.7,ANAPC16THYMGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.3062e-040.3450image
chr10:72233982-72235492:+THYMGSVA_HALLMARK_PROTEIN_SECRETIONEER4.1921e-050.3677image
ENSG00000166295.7,ANAPC16UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.9298e-040.2790image
chr10:72233982-72235492:+UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER8.1996e-040.2521image
chr10:72233982-72235492:+UCSGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER7.3639e-040.4380image
ENSG00000166295.7,ANAPC16UCSGSVA_HALLMARK_P53_PATHWAYEAG1.3267e-030.4185image
chr10:72233982-72235492:+UVMGSVA_HALLMARK_PANCREAS_BETA_CELLSEER6.6422e-040.3945image
ENSG00000166295.7,ANAPC16UVMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG4.3942e-030.3319image


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7. Enriched editing regions and drugs for ANAPC16


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000166295.7,ANAPC16ACCAZD8055EAG4.0138e-020.2329image
chr10:72233982-72235492:+ACCAZD8055EER3.5541e-020.2384image
ENSG00000166295.7,ANAPC16BLCACMKEAG1.8716e-08-0.2749image
chr10:72233982-72235492:+BLCACMKEER1.7851e-09-0.2936image
chr10:72233982-72235492:+BRCACEP.701EER5.4161e-070.1520image
ENSG00000166295.7,ANAPC16BRCACEP.701EAG4.3065e-070.1532image
chr10:72219525-72223358:+BRCACCT007093EER2.9900e-05-0.1935image
chr10:72233982-72235492:+CESCGNF.2EER2.5201e-05-0.2395image
ENSG00000166295.7,ANAPC16CESCGNF.2EAG5.5825e-05-0.2294image
chr10:72233982-72235492:+CHOLAZ628EER1.6933e-030.5113image
ENSG00000166295.7,ANAPC16CHOLAZ628EAG2.8792e-030.4889image
chr10:72233982-72235492:+COADCCT007093EER6.7401e-05-0.2418image
ENSG00000166295.7,ANAPC16COADJNJ.26854165EAG7.8232e-04-0.2036image
ENSG00000166295.7,ANAPC16DLBCCytarabineEAG1.4256e-020.3516image
chr10:72233982-72235492:+DLBCCytarabineEER3.5798e-020.3038image
chr10:72233982-72235492:+ESCACMKEER2.2664e-03-0.2397image
ENSG00000166295.7,ANAPC16ESCAGNF.2EAG4.0944e-030.2251image
chr10:72224387-72226637:+ESCAAICAREER1.3541e-04-0.3607image
chr10:72219525-72223358:+ESCAGNF.2EER5.7443e-060.3654image
ENSG00000166295.7,ANAPC16GBMFTI.277EAG2.9905e-020.1691image
chr10:72233982-72235492:+GBMGW.441756EER1.7785e-020.1854image
chr10:72233982-72235492:+HNSCBMS.708163EER6.1499e-16-0.3533image
ENSG00000166295.7,ANAPC16HNSCBMS.708163EAG4.1279e-14-0.3303image
ENSG00000166295.7,ANAPC16KICHLFM.A13EAG5.9444e-030.3377image
chr10:72233982-72235492:+KICHEHT.1864EER1.7246e-020.2945image
ENSG00000166295.7,ANAPC16KIRCBMS.708163EAG3.8522e-05-0.2081image
chr10:72219525-72223358:+KIRCMethotrexateEER1.7607e-04-0.3220image
chr10:72233982-72235492:+KIRCLapatinibEER3.8533e-05-0.2087image
chr10:72219525-72223358:+KIRPGW.441756EER9.4444e-040.4036image
chr10:72233982-72235492:+KIRPDMOGEER5.2175e-04-0.2032image
ENSG00000166295.7,ANAPC16KIRPGW.441756EAG7.2235e-04-0.1981image
ENSG00000166295.7,ANAPC16LAMLCisplatinEAG1.8277e-03-0.2729image
chr10:72233982-72235492:+LAMLCisplatinEER2.3379e-06-0.4094image
chr10:72219525-72223358:+LAMLGDC0941EER1.9772e-02-0.2800image
ENSG00000166295.7,ANAPC16LGGBMS.536924EAG9.2137e-050.1697image
chr10:72233982-72235492:+LGGBMS.536924EER3.2227e-060.2014image
ENSG00000166295.7,ANAPC16LIHCFTI.277EAG2.7162e-070.2624image
chr10:72233982-72235492:+LIHCFTI.277EER8.5956e-090.2929image
chr10:72233982-72235492:+LUADCGP.082996EER3.2147e-06-0.2047image
ENSG00000166295.7,ANAPC16LUADDocetaxelEAG9.8193e-07-0.2139image
ENSG00000166295.7,ANAPC16LUSCGNF.2EAG1.0185e-03-0.1468image
chr10:72233982-72235492:+LUSCCGP.082996EER6.9832e-04-0.1516image
ENSG00000166295.7,ANAPC16MESOCGP.082996EAG3.1053e-04-0.3885image
chr10:72233982-72235492:+MESOBortezomibEER2.0554e-04-0.3989image
chr10:72224387-72226637:+OVJNK.Inhibitor.VIIIEER3.5950e-02-0.3136image
chr10:72219525-72223358:+OVAS601245EER1.7512e-02-0.1487image
chr10:72233982-72235492:+OVAG.014699EER1.8853e-050.2475image
ENSG00000166295.7,ANAPC16OVAxitinibEAG4.1492e-050.2375image
chr10:72233982-72235492:+PAADAZD8055EER3.4106e-040.2655image
ENSG00000166295.7,ANAPC16PAADAZD8055EAG7.8848e-040.2494image
chr10:72233982-72235492:+PCPGBosutinibEER1.8820e-050.3106image
ENSG00000166295.7,ANAPC16PCPGBosutinibEAG4.0440e-040.2588image
ENSG00000166295.7,ANAPC16PRADBMS.754807EAG4.7944e-060.2031image
chr10:72233982-72235492:+PRADBMS.754807EER2.4872e-070.2284image
ENSG00000166295.7,ANAPC16READAMG.706EAG1.1268e-020.2617image
chr10:72233982-72235492:+READAMG.706EER1.7970e-020.2449image
ENSG00000166295.7,ANAPC16SARCCisplatinEAG7.4490e-04-0.2099image
chr10:72233982-72235492:+SARCCisplatinEER2.2369e-03-0.1906image
chr10:72233982-72235492:+SKCMGNF.2EER1.3945e-06-0.2264image
ENSG00000166295.7,ANAPC16SKCMAxitinibEAG2.4156e-030.1419image
ENSG00000166295.7,ANAPC16STADImatinibEAG3.9053e-050.2150image
chr10:72219525-72223358:+STADBexaroteneEER3.1856e-050.2377image
chr10:72233982-72235492:+STADCCT007093EER2.2322e-050.2230image
chr10:72224387-72226637:+STADATRAEER1.0183e-040.2920image
chr10:72233982-72235492:+TGCTAxitinibEER1.5934e-05-0.3444image
ENSG00000166295.7,ANAPC16TGCTEHT.1864EAG1.4150e-050.3452image
chr10:72233982-72235492:+THCAAMG.706EER4.0022e-120.3025image
chr10:72219525-72223358:+THCAIPA.3EER1.4857e-03-0.2615image
ENSG00000166295.7,ANAPC16THCAAMG.706EAG1.9556e-100.2786image
chr10:72233982-72235492:+THYMGSK269962AEER9.6043e-090.4980image
ENSG00000166295.7,ANAPC16THYMGSK269962AEAG1.3802e-070.4621image
chr10:72233982-72235492:+UCECCisplatinEER1.0698e-05-0.3278image
ENSG00000166295.7,ANAPC16UCECCisplatinEAG5.0041e-04-0.2612image
chr10:72233982-72235492:+UCSMG.132EER1.7464e-06-0.5896image
ENSG00000166295.7,ANAPC16UCSMG.132EAG1.1649e-06-0.5975image
ENSG00000166295.7,ANAPC16UVMGNF.2EAG1.6777e-02-0.2811image
chr10:72233982-72235492:+UVMGNF.2EER7.3919e-03-0.3153image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType