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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: CFAP36 (ImmuneEditome ID:112942)

1. Gene summary of enriched editing regions for CFAP36

check button Gene summary
Gene informationGene symbol

CFAP36

Gene ID

112942

GeneSynonymsBARTL1|CCDC104
GeneCytomap

2p16.1

GeneTypeprotein-coding
GeneDescriptioncilia- and flagella-associated protein 36|coiled-coil domain containing 104|coiled-coil domain-containing protein 104
GeneModificationdate20230329
UniprotIDQ96G28;B5MCA1;B5MC35;B5MD16
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr2:55524310-55525937:+ENST00000339012.6ENSG00000163001.10CFAP36intronicAluSp,MIR,AluSq2,AluJo,(T)n,AluJrchr2:55524310-55525937:+.alignment
chr2:55524310-55525937:+ENST00000349456.7ENSG00000163001.10CFAP36intronicAluSp,MIR,AluSq2,AluJo,(T)n,AluJrchr2:55524310-55525937:+.alignment
chr2:55524310-55525937:+ENST00000403007.4ENSG00000163001.10CFAP36intronicAluSp,MIR,AluSq2,AluJo,(T)n,AluJrchr2:55524310-55525937:+.alignment
chr2:55524310-55525937:+ENST00000406691.6ENSG00000163001.10CFAP36intronicAluSp,MIR,AluSq2,AluJo,(T)n,AluJrchr2:55524310-55525937:+.alignment
chr2:55524310-55525937:+ENST00000407816.6ENSG00000163001.10CFAP36intronicAluSp,MIR,AluSq2,AluJo,(T)n,AluJrchr2:55524310-55525937:+.alignment
chr2:55536825-55537365:+ENST00000490934.1ENSG00000163001.10CFAP36ncRNA_intronicAluSz6,AluSx1chr2:55536825-55537365:+.alignment
chr2:55538525-55538744:+ENST00000490934.1ENSG00000163001.10CFAP36ncRNA_intronicAluJr,AluSpchr2:55538525-55538744:+.alignment
chr2:55540712-55541358:+ENST00000490934.1ENSG00000163001.10CFAP36ncRNA_intronicL1MC1,AluJb,AluSq2chr2:55540712-55541358:+.alignment


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2. Tumor-specific enriched editing regions for CFAP36


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr2:55538525-55538744:+OVCliEER2.1946e-022.1946e-020.4653image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for CFAP36


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for CFAP36


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for CFAP36


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr2:55540712-55541358:+BRCAEERT_cells_CD4_memory_activated1.0938e-020.4310image
ENSG00000163001.10,CFAP36BRCAEAGT_cells_CD83.2517e-02-0.2335image
ENSG00000163001.10,CFAP36GBMEAGMast_cells_resting3.7855e-020.2452image
chr2:55536825-55537365:+KIRCEERDendritic_cells_activated3.8576e-030.4364image
ENSG00000163001.10,CFAP36KIRCEAGT_cells_regulatory_(Tregs)1.2906e-020.2687image
ENSG00000163001.10,CFAP36KIRPEAGT_cells_gamma_delta2.6642e-020.3504image
chr2:55540712-55541358:+LGGEERNK_cells_resting7.0327e-03-0.1605image
ENSG00000163001.10,CFAP36LUADEAGT_cells_follicular_helper2.8263e-020.3386image
ENSG00000163001.10,CFAP36LUSCEAGT_cells_follicular_helper1.6723e-020.5042image
chr2:55524310-55525937:+OVEERDendritic_cells_resting2.0244e-020.4807image
chr2:55536825-55537365:+OVEERT_cells_CD4_memory_resting3.1154e-020.4080image
chr2:55540712-55541358:+OVEERMacrophages_M01.2019e-03-0.3742image
ENSG00000163001.10,CFAP36OVEAGDendritic_cells_resting9.7976e-030.2510image
chr2:55540712-55541358:+PCPGEERNK_cells_resting3.1009e-030.3535image
ENSG00000163001.10,CFAP36PCPGEAGNK_cells_resting1.4033e-030.3695image
ENSG00000163001.10,CFAP36PRADEAGT_cells_follicular_helper8.4725e-030.4266image
chr2:55536825-55537365:+STADEERDendritic_cells_resting3.4606e-050.7193image
ENSG00000163001.10,CFAP36STADEAGDendritic_cells_resting1.1149e-020.3153image
ENSG00000163001.10,CFAP36UCECEAGT_cells_CD82.6780e-020.4424image


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6. Enriched editing regions and immune gene sets for CFAP36


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000163001.10,CFAP36BRCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG4.1599e-030.3096image
chr2:55540712-55541358:+BRCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER2.7192e-02-0.3787image
ENSG00000163001.10,CFAP36GBMGSVA_HALLMARK_SPERMATOGENESISEAG3.5303e-02-0.2485image
chr2:55540712-55541358:+GBMGSVA_HALLMARK_COMPLEMENTEER6.4908e-030.3343image
ENSG00000163001.10,CFAP36KIRCGSVA_HALLMARK_MYOGENESISEAG4.1977e-020.2211image
chr2:55540712-55541358:+KIRCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.4142e-020.4410image
ENSG00000163001.10,CFAP36KIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.7842e-030.4786image
chr2:55540712-55541358:+LGGGSVA_HALLMARK_COAGULATIONEER1.5799e-020.1439image
ENSG00000163001.10,CFAP36LGGGSVA_HALLMARK_ANGIOGENESISEAG3.5816e-020.1202image
ENSG00000163001.10,CFAP36LUADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG2.4538e-030.4552image
ENSG00000163001.10,CFAP36OVGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG2.0648e-030.2974image
chr2:55536825-55537365:+OVGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER1.5556e-020.4527image
chr2:55540712-55541358:+OVGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER6.3335e-040.3932image
chr2:55524310-55525937:+OVGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER6.3840e-030.5514image
ENSG00000163001.10,CFAP36PRADGSVA_HALLMARK_ANGIOGENESISEAG4.8495e-02-0.3266image
chr2:55536825-55537365:+STADGSVA_HALLMARK_FATTY_ACID_METABOLISMEER4.9770e-020.3886image
ENSG00000163001.10,CFAP36THCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.4091e-02-0.1574image
chr2:55540712-55541358:+THCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.5374e-020.1793image
ENSG00000163001.10,CFAP36UCECGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG2.9151e-020.4365image


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7. Enriched editing regions and drugs for CFAP36


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000163001.10,CFAP36BRCAEHT.1864EAG1.1992e-030.3475image
chr2:55540712-55541358:+BRCABosutinibEER1.6014e-020.4101image
ENSG00000163001.10,CFAP36ESCAGW.441756EAG2.5612e-020.3220image
ENSG00000163001.10,CFAP36GBMGW843682XEAG4.9320e-02-0.2326image
chr2:55540712-55541358:+GBMAICAREER1.6124e-03-0.3835image
ENSG00000163001.10,CFAP36KIRCCyclopamineEAG8.3418e-03-0.2844image
chr2:55536825-55537365:+KIRCDoxorubicinEER8.8441e-030.3991image
chr2:55540712-55541358:+KIRCCI.1040EER1.4077e-02-0.4755image
ENSG00000163001.10,CFAP36KIRPBAY.61.3606EAG8.8739e-070.6889image
chr2:55540712-55541358:+LGGKU.55933EER3.4969e-03-0.1737image
ENSG00000163001.10,CFAP36LGGCHIR.99021EAG2.2943e-03-0.1740image
ENSG00000163001.10,CFAP36LUADKIN001.135EAG6.3609e-03-0.4144image
ENSG00000163001.10,CFAP36OVCI.1040EAG6.5258e-05-0.3795image
chr2:55536825-55537365:+OVLFM.A13EER6.7441e-030.5000image
chr2:55540712-55541358:+OVAZD6244EER1.5045e-04-0.4321image
chr2:55524310-55525937:+OVGNF.2EER3.0445e-02-0.4518image
chr2:55540712-55541358:+PCPGImatinibEER3.9890e-03-0.3448image
ENSG00000163001.10,CFAP36PCPGImatinibEAG4.7812e-03-0.3290image
ENSG00000163001.10,CFAP36PRADFTI.277EAG4.1225e-030.4606image
ENSG00000163001.10,CFAP36STADBX.795EAG2.1468e-020.2870image
chr2:55536825-55537365:+STADATRAEER1.6513e-020.4656image
ENSG00000163001.10,CFAP36TGCTBMS.509744EAG4.5259e-02-0.4412image
ENSG00000163001.10,CFAP36THCAAICAREAG1.8209e-050.3279image
chr2:55540712-55541358:+THCACCT007093EER1.0238e-040.3404image
ENSG00000163001.10,CFAP36UCECAZD7762EAG6.3441e-05-0.7130image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType