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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: PXMP4 (ImmuneEditome ID:11264)

1. Gene summary of enriched editing regions for PXMP4

check button Gene summary
Gene informationGene symbol

PXMP4

Gene ID

11264

GeneSynonymsPMP24
GeneCytomap

20q11.22

GeneTypeprotein-coding
GeneDescriptionperoxisomal membrane protein 4|24 kDa peroxisomal intrinsic membrane protein|peroxisomal membrane protein 4, 24kDa
GeneModificationdate20230329
UniprotIDQ9Y6I8;B4DWH1
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr20:33704947-33707196:-ENST00000409299.6ENSG00000101417.10PXMP4UTR3AluJb,AluJr,AluSx,MIRc,MIRb,AluSx1,MER33,AluYchr20:33704947-33707196:-.alignment


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2. Tumor-specific enriched editing regions for PXMP4


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr20:33704947-33707196:-BRCAEER2.2013e-17image
ENSG00000101417.10,PXMP4BRCAEAG5.0333e-09image
chr20:33704947-33707196:-COADEER1.2334e-12image
ENSG00000101417.10,PXMP4COADEAG1.6358e-10image
chr20:33704947-33707196:-HNSCEER1.8245e-13image
ENSG00000101417.10,PXMP4HNSCEAG6.1305e-08image
chr20:33704947-33707196:-KICHEER1.1615e-03image
ENSG00000101417.10,PXMP4KICHEAG5.7892e-04image
chr20:33704947-33707196:-KIRCEER3.5092e-10image
ENSG00000101417.10,PXMP4KIRCEAG4.8995e-04image
chr20:33704947-33707196:-KIRPEER2.6555e-05image
ENSG00000101417.10,PXMP4KIRPEAG1.1497e-04image
chr20:33704947-33707196:-LUADEER1.4933e-15image
ENSG00000101417.10,PXMP4LUADEAG2.9174e-08image
chr20:33704947-33707196:-LUSCEER2.3796e-19image
ENSG00000101417.10,PXMP4LUSCEAG2.2574e-12image
chr20:33704947-33707196:-THCAEER1.3612e-11image
ENSG00000101417.10,PXMP4THCAEAG3.0673e-09image
ENSG00000101417.10,PXMP4UCECEAG1.2451e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000101417.10,PXMP4HNSCPathEAG9.5522e-037.2098e-03-0.1406image
chr20:33704947-33707196:-LUADPathEER2.4455e-033.7711e-020.0956image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr20:33704947-33707196:-UCECEER6.7579e-033.1548e-021.6954e-02image

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3. Enriched editing regions and immune related genes for PXMP4


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr20:33704947-33707196:-LGGEERENSG00000101417,PXMP4-0.39566.8684e-184.3294e-23-0.4189imageNDKC1;EIF4A3;FBL;HNRNPA1;LIN28B;MSI1;U2AF2;UPF1;YTHDC1NAT_cells_follicular_helperGSVA_HALLMARK_E2F_TARGETS
chr20:33704947-33707196:-CESCEERENSG00000204525,HLA-C0.32466.5612e-056.1378e-120.4217imageNDKC1;EIF4A3;FBL;HNRNPA1;LIN28B;U2AF2;UPF1HLA-CT_cells_CD8GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr20:33704947-33707196:-COADEERENSG00000101417,PXMP4-0.48751.0590e-117.4021e-17-0.4882imageNDKC1;EIF4A3;FBL;HNRNPA1;LIN28B;MSI1;U2AF2;UPF1;YTHDC1NAT_cells_CD4_memory_activatedGSVA_HALLMARK_BILE_ACID_METABOLISM
chr20:33704947-33707196:-COADEERENSG00000126003,PLAGL2-0.45257.6794e-101.7191e-11-0.4029imageNDKC1;EIF4A3;FBL;HNRNPA1;LIN28B;MSI1;U2AF2;UPF1;YTHDC1PLAGL2T_cells_CD4_memory_activatedGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr20:33704947-33707196:-COADEERENSG00000168612,ZSWIM1-0.43076.5135e-097.3555e-12-0.4096imageNEIF4A3;FBL;HNRNPA1;LIN28B;MSI1;U2AF2;UPF1;YTHDC1NAT_cells_CD4_memory_activatedGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr20:33704947-33707196:-COADEERENSG00000101346,POFUT1-0.42411.2220e-084.2240e-12-0.4139imageNDKC1;EIF4A3;FBL;HNRNPA1;LIN28B;MSI1;U2AF2;UPF1;YTHDC1NAMacrophages_M0GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr20:33704947-33707196:-COADEERENSG00000131043,AAR2-0.41811.8305e-083.5749e-12-0.4152imageNDKC1;EIF4A3;FBL;HNRNPA1;LIN28B;U2AF2;UPF1;YTHDC1NAMacrophages_M0GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr20:33704947-33707196:-COADEERENSG00000125970,RALY-0.41432.4119e-081.5745e-11-0.4036imageNDKC1;EIF4A3;FBL;HNRNPA1;LIN28B;MSI1;U2AF2;UPF1;YTHDC1NAT_cells_CD4_memory_activatedGSVA_HALLMARK_DNA_REPAIR
chr20:33704947-33707196:-COADEERENSG00000101464,PIGU-0.41273.9308e-085.2586e-12-0.4122imageNDKC1;EIF4A3;FBL;HNRNPA1;LIN28B;MSI1;U2AF2;UPF1;YTHDC1NAT_cells_CD4_memory_activatedGSVA_HALLMARK_MYC_TARGETS_V2
chr20:33704947-33707196:-COADEERENSG00000128203,ASPHD20.39151.7232e-071.0314e-110.4070imageNDKC1;FBL;MSI1;U2AF2;UPF1;YTHDC1NAMacrophages_M1GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE

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4. Enriched editing regions and immune related splicing for PXMP4


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr20:33704947-33707196:-
COADEERIRENSG00000100453.8chr1424631538:24632118:24632323:24632459-0.39881.7573e-082.4208e-12-0.4468imageNDKC1GZMBT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
ENSG00000101417.10,PXMP4
COADEAGIRENSG00000100453.8chr1424631538:24632118:24632323:24632459-0.37432.7072e-074.1045e-11-0.4225imageNDKC1;TAF15GZMBT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
ENSG00000101417.10,PXMP4
KIRPEAGA3ENSG00000178927.12chr1782444446:82444528:82443448:82443505:82443448:824441240.23382.0010e-027.0069e-110.4003imageNADAR;CSTF2T;DDX3X;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LIN28B;MOV10;MSI2;NOP56;NOP58;NUMA1;PRPF8;PTBP1;QKI;RBM10;RBM27;SAFB2;SLTM;SND1;SRSF1;TAF15;TNRC6A;TROVE2;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000101417.10,PXMP4
KIRPEAGIRENSG00000136448.7chr1745105764:45105945:45107778:45108134-0.23392.1165e-025.1024e-14-0.4557imageNADAR;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28A;LIN28B;MBNL2;MOV10;MSI1;MSI2;NOP56;NOP58;NUMA1;PRPF8;PTBP1;PUM2;QKI;RBM10;RBM27;RTCB;SAFB2;SLTM;SND1;SRSF1;TAF15;TNRC6A;TROVE2;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
chr20:33704947-33707196:-
KIRPEERIRENSG00000187109.9chr1276046903:76047718:76048420:76048464-0.39622.9132e-079.6690e-13-0.4368imageNDKC1;EIF4A3;FBL;HNRNPA1;LIN28B;MSI1;U2AF2;UPF1;YTHDC1NAMast_cells_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr20:33704947-33707196:-
KIRPEERA3ENSG00000178927.12chr1782444446:82444528:82443448:82443505:82443448:824441240.24741.0609e-021.7762e-110.4139imageNDKC1;EIF4A3;FBL;HNRNPA1;LIN28B;U2AF2;UPF1;YTHDC1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
chr20:33704947-33707196:-
KIRPEERIRENSG00000166439.5chr1174836491:74836761:74842144:74842214-0.24385.9378e-049.9415e-13-0.4538imageNDKC1;EIF4A3;FBL;HNRNPA1;LIN28B;MSI1;U2AF2;UPF1;YTHDC1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000101417.10,PXMP4
KIRPEAGIRENSG00000136485.10chr1763588999:63589237:63594202:63594259-0.30942.3792e-047.3620e-13-0.4364imageNADAR;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28A;LIN28B;MBNL2;MOV10;MSI1;MSI2;NOP56;NOP58;NUMA1;PRPF8;PTBP1;PUM2;QKI;RBM10;RBM27;RTCB;SAFB2;SLTM;SND1;SRSF1;TAF15;TNRC6A;TROVE2;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000101417.10,PXMP4
KIRPEAGIRENSG00000196422.6chr9135483362:135484082:135488471:135488613-0.25715.0224e-034.4148e-11-0.4041imageNADAR;CSTF2T;DDX3X;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LIN28A;LIN28B;MOV10;MSI2;NOP58;NUMA1;PRPF8;PTBP1;PUM2;RBM27;SAFB2;SLTM;SND1;SRSF1;TAF15;TNRC6A;TROVE2;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1NAT_cells_gamma_deltaGSVA_HALLMARK_MITOTIC_SPINDLE
chr20:33704947-33707196:-
KIRPEERIRENSG00000136448.7chr1745105764:45105945:45107778:45108134-0.23861.7323e-026.8325e-14-0.4562imageNDKC1;EIF4A3;FBL;HNRNPA1;LIN28B;MSI1;U2AF2;UPF1;YTHDC1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION

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5. Enriched editing regions and immune infiltration for PXMP4


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr20:33704947-33707196:-ACCEERT_cells_gamma_delta3.7775e-030.3492image
ENSG00000101417.10,PXMP4ACCEAGT_cells_gamma_delta3.1849e-030.3526image
chr20:33704947-33707196:-BLCAEERB_cells_memory2.8379e-02-0.1203image
ENSG00000101417.10,PXMP4BLCAEAGMonocytes2.9923e-020.1148image
chr20:33704947-33707196:-BRCAEERMacrophages_M12.2069e-050.1350image
ENSG00000101417.10,PXMP4BRCAEAGB_cells_memory3.5399e-030.0922image
chr20:33704947-33707196:-CESCEERT_cells_CD84.6350e-030.1807image
ENSG00000101417.10,PXMP4CHOLEAGT_cells_CD4_memory_resting2.7776e-02-0.3831image
chr20:33704947-33707196:-COADEERMacrophages_M12.4635e-030.1877image
ENSG00000101417.10,PXMP4COADEAGMacrophages_M13.4295e-020.1316image
chr20:33704947-33707196:-ESCAEERT_cells_CD4_naive6.2610e-040.2700image
chr20:33704947-33707196:-GBMEERB_cells_memory3.5334e-040.2799image
ENSG00000101417.10,PXMP4GBMEAGB_cells_memory6.8856e-040.2664image
chr20:33704947-33707196:-HNSCEERMacrophages_M12.5361e-030.1515image
ENSG00000101417.10,PXMP4HNSCEAGT_cells_CD4_memory_resting2.2344e-020.1120image
chr20:33704947-33707196:-KICHEERMonocytes1.1663e-020.3135image
ENSG00000101417.10,PXMP4KICHEAGMonocytes7.1786e-030.3304image
chr20:33704947-33707196:-KIRCEERMacrophages_M22.1016e-03-0.1682image
ENSG00000101417.10,PXMP4KIRCEAGT_cells_CD4_memory_activated1.2206e-02-0.1352image
chr20:33704947-33707196:-KIRPEERT_cells_CD4_memory_resting5.9790e-04-0.2187image
ENSG00000101417.10,PXMP4KIRPEAGT_cells_CD4_memory_resting1.1403e-02-0.1611image
chr20:33704947-33707196:-LAMLEERT_cells_regulatory_(Tregs)8.4086e-030.5151image
ENSG00000101417.10,PXMP4LAMLEAGT_cells_regulatory_(Tregs)8.4086e-030.5151image
chr20:33704947-33707196:-LGGEERDendritic_cells_resting9.2079e-060.1950image
ENSG00000101417.10,PXMP4LGGEAGDendritic_cells_resting1.5745e-060.2107image
ENSG00000101417.10,PXMP4LIHCEAGT_cells_regulatory_(Tregs)2.8141e-02-0.1175image
chr20:33704947-33707196:-LUADEERT_cells_CD82.9163e-040.1660image
ENSG00000101417.10,PXMP4LUADEAGT_cells_CD81.8428e-020.1077image
chr20:33704947-33707196:-LUSCEERT_cells_CD4_memory_activated8.3642e-050.1860image
ENSG00000101417.10,PXMP4LUSCEAGT_cells_CD4_memory_activated2.5903e-020.1041image
chr20:33704947-33707196:-MESOEERMacrophages_M23.3672e-020.2456image
ENSG00000101417.10,PXMP4MESOEAGMacrophages_M21.0711e-020.2875image
chr20:33704947-33707196:-OVEERT_cells_CD4_naive3.0171e-02-0.1296image
ENSG00000101417.10,PXMP4OVEAGEosinophils7.4017e-05-0.2333image
chr20:33704947-33707196:-PAADEERT_cells_follicular_helper1.4558e-030.2620image
ENSG00000101417.10,PXMP4PAADEAGT_cells_CD83.5291e-020.1692image
chr20:33704947-33707196:-PCPGEERPlasma_cells3.3319e-040.2939image
ENSG00000101417.10,PXMP4PCPGEAGNK_cells_activated4.1760e-02-0.1654image
chr20:33704947-33707196:-PRADEERT_cells_regulatory_(Tregs)6.3220e-070.2239image
ENSG00000101417.10,PXMP4PRADEAGT_cells_CD86.1694e-040.1548image
chr20:33704947-33707196:-READEERMacrophages_M22.6161e-040.3681image
ENSG00000101417.10,PXMP4READEAGMast_cells_activated3.8343e-020.2140image
chr20:33704947-33707196:-SARCEERB_cells_naive1.7210e-03-0.2052image
ENSG00000101417.10,PXMP4SARCEAGMacrophages_M03.4960e-020.1374image
chr20:33704947-33707196:-SKCMEERNK_cells_resting3.0542e-04-0.1731image
ENSG00000101417.10,PXMP4SKCMEAGNK_cells_resting1.8083e-04-0.1788image
chr20:33704947-33707196:-STADEERT_cells_CD4_memory_activated6.4460e-040.1855image
ENSG00000101417.10,PXMP4STADEAGT_cells_CD83.1784e-040.1938image
chr20:33704947-33707196:-TGCTEERDendritic_cells_activated2.2885e-02-0.2384image
ENSG00000101417.10,PXMP4TGCTEAGT_cells_regulatory_(Tregs)1.9298e-03-0.2758image
chr20:33704947-33707196:-THCAEERT_cells_regulatory_(Tregs)4.2141e-040.1595image
ENSG00000101417.10,PXMP4THCAEAGPlasma_cells2.1795e-040.1668image
chr20:33704947-33707196:-THYMEERNK_cells_resting1.3590e-02-0.2565image
ENSG00000101417.10,PXMP4THYMEAGB_cells_memory2.3419e-02-0.2312image
chr20:33704947-33707196:-UCECEERDendritic_cells_resting3.7861e-020.1939image
ENSG00000101417.10,PXMP4UCECEAGDendritic_cells_resting4.5675e-030.2436image
chr20:33704947-33707196:-UVMEERMacrophages_M03.9092e-020.2628image
ENSG00000101417.10,PXMP4UVMEAGMacrophages_M03.8954e-020.2629image


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6. Enriched editing regions and immune gene sets for PXMP4


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr20:33704947-33707196:-KIRCEER3.0722e-040.19697.9123e-030.14551.0076e-030.17977.8839e-030.1456image
chr20:33704947-33707196:-LUADEER3.8780e-070.23101.3601e-050.19881.6667e-060.21841.2696e-040.1755image
ENSG00000101417.10,PXMP4LUADEAG9.8421e-040.15012.4121e-020.10303.0673e-030.13508.5352e-050.1785image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr20:33704947-33707196:-ACCGSVA_HALLMARK_PROTEIN_SECRETIONEER4.4017e-03-0.3437image
ENSG00000101417.10,PXMP4ACCGSVA_HALLMARK_PROTEIN_SECRETIONEAG5.4779e-03-0.3333image
chr20:33704947-33707196:-BLCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.1617e-050.2203image
chr20:33704947-33707196:-BRCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER3.2598e-090.1875image
ENSG00000101417.10,PXMP4BRCAGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG1.0217e-040.1226image
ENSG00000101417.10,PXMP4CESCGSVA_HALLMARK_HEME_METABOLISMEAG6.1374e-040.2095image
chr20:33704947-33707196:-CESCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER9.2180e-060.2797image
ENSG00000101417.10,PXMP4CHOLGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG3.2721e-030.4968image
chr20:33704947-33707196:-CHOLGSVA_HALLMARK_UV_RESPONSE_UPEER2.0855e-030.5239image
chr20:33704947-33707196:-COADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER6.5498e-090.3514image
ENSG00000101417.10,PXMP4COADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG8.0001e-070.3010image
chr20:33704947-33707196:-ESCAGSVA_HALLMARK_PROTEIN_SECRETIONEER1.0152e-040.3052image
ENSG00000101417.10,PXMP4ESCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG8.1471e-040.2637image
ENSG00000101417.10,PXMP4GBMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG6.3961e-050.3116image
chr20:33704947-33707196:-GBMGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER7.5507e-060.3468image
ENSG00000101417.10,PXMP4HNSCGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.9805e-030.1453image
chr20:33704947-33707196:-HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.6193e-040.1754image
ENSG00000101417.10,PXMP4KICHGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG3.6418e-03-0.3557image
chr20:33704947-33707196:-KICHGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER4.5095e-04-0.4258image
chr20:33704947-33707196:-KIRCGSVA_HALLMARK_PROTEIN_SECRETIONEER3.9316e-04-0.1934image
ENSG00000101417.10,PXMP4KIRCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG5.4733e-060.2427image
ENSG00000101417.10,PXMP4KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.2837e-06-0.3030image
chr20:33704947-33707196:-KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEER1.1521e-08-0.3559image
chr20:33704947-33707196:-LAMLGSVA_HALLMARK_APICAL_JUNCTIONEER6.5279e-040.6348image
ENSG00000101417.10,PXMP4LAMLGSVA_HALLMARK_APICAL_JUNCTIONEAG6.5279e-040.6348image
chr20:33704947-33707196:-LGGGSVA_HALLMARK_MITOTIC_SPINDLEEER2.0984e-08-0.2450image
ENSG00000101417.10,PXMP4LGGGSVA_HALLMARK_MITOTIC_SPINDLEEAG9.0277e-08-0.2340image
ENSG00000101417.10,PXMP4LIHCGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.3366e-040.1958image
chr20:33704947-33707196:-LIHCGSVA_HALLMARK_E2F_TARGETSEER2.6652e-03-0.1684image
chr20:33704947-33707196:-LUADGSVA_HALLMARK_GLYCOLYSISEER1.2549e-060.2209image
ENSG00000101417.10,PXMP4LUADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG5.6953e-050.1828image
chr20:33704947-33707196:-LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.0925e-040.1755image
ENSG00000101417.10,PXMP4LUSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.1767e-020.1176image
chr20:33704947-33707196:-MESOGSVA_HALLMARK_E2F_TARGETSEER2.2745e-020.2628image
ENSG00000101417.10,PXMP4OVGSVA_HALLMARK_COAGULATIONEAG4.3015e-030.1692image
chr20:33704947-33707196:-OVGSVA_HALLMARK_MITOTIC_SPINDLEEER3.7428e-03-0.1727image
ENSG00000101417.10,PXMP4PAADGSVA_HALLMARK_GLYCOLYSISEAG4.5113e-02-0.1612image
chr20:33704947-33707196:-PAADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.7374e-020.1973image
ENSG00000101417.10,PXMP4PCPGGSVA_HALLMARK_APOPTOSISEAG9.4659e-030.2098image
chr20:33704947-33707196:-PCPGGSVA_HALLMARK_MITOTIC_SPINDLEEER6.0856e-04-0.2813image
ENSG00000101417.10,PXMP4PRADGSVA_HALLMARK_ANDROGEN_RESPONSEEAG2.3262e-10-0.2824image
chr20:33704947-33707196:-PRADGSVA_HALLMARK_ANDROGEN_RESPONSEEER3.6909e-12-0.3086image
chr20:33704947-33707196:-READGSVA_HALLMARK_MYC_TARGETS_V2EER6.2400e-04-0.3465image
ENSG00000101417.10,PXMP4READGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG2.5626e-040.3686image
ENSG00000101417.10,PXMP4SARCGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG8.3040e-030.1714image
chr20:33704947-33707196:-SARCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER9.0257e-040.2170image
ENSG00000101417.10,PXMP4SKCMGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG2.7770e-040.1737image
chr20:33704947-33707196:-SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.1448e-060.2224image
ENSG00000101417.10,PXMP4STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.0930e-040.1942image
chr20:33704947-33707196:-STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.0525e-080.3062image
ENSG00000101417.10,PXMP4TGCTGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.5057e-04-0.3160image
chr20:33704947-33707196:-TGCTGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.3053e-020.2593image
chr20:33704947-33707196:-THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER2.7304e-100.2816image
ENSG00000101417.10,PXMP4THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG2.2646e-070.2320image
ENSG00000101417.10,PXMP4THYMGSVA_HALLMARK_UV_RESPONSE_UPEAG2.9352e-02-0.2225image
chr20:33704947-33707196:-THYMGSVA_HALLMARK_APICAL_SURFACEEER4.1357e-020.2131image
ENSG00000101417.10,PXMP4UCECGSVA_HALLMARK_HEME_METABOLISMEAG5.2703e-030.2397image


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7. Enriched editing regions and drugs for PXMP4


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr20:33704947-33707196:-ACCEpothilone.BEER3.8190e-020.2538image
ENSG00000101417.10,PXMP4ACCEpothilone.BEAG4.4212e-020.2448image
chr20:33704947-33707196:-BLCAGDC.0449EER1.8062e-05-0.2330image
ENSG00000101417.10,PXMP4BLCAJNK.9LEAG1.2313e-02-0.1322image
ENSG00000101417.10,PXMP4BRCAEHT.1864EAG9.7879e-060.1393image
chr20:33704947-33707196:-BRCAAZD.2281EER7.3455e-08-0.1709image
ENSG00000101417.10,PXMP4CESCAZD6482EAG2.5544e-04-0.2233image
chr20:33704947-33707196:-CESCAZD.2281EER1.5195e-06-0.3022image
ENSG00000101417.10,PXMP4CHOLMetforminEAG3.6408e-030.4919image
chr20:33704947-33707196:-CHOLDasatinibEER3.6233e-02-0.3716image
ENSG00000101417.10,PXMP4COADBIRB.0796EAG4.0297e-050.2522image
chr20:33704947-33707196:-COADBI.D1870EER1.5650e-06-0.2938image
ENSG00000101417.10,PXMP4ESCACI.1040EAG6.1729e-03-0.2170image
chr20:33704947-33707196:-ESCAABT.263EER3.0660e-020.1731image
chr20:33704947-33707196:-GBMCGP.082996EER1.8161e-06-0.3680image
ENSG00000101417.10,PXMP4GBMCGP.082996EAG1.4628e-05-0.3363image
ENSG00000101417.10,PXMP4HNSCJW.7.52.1EAG2.8777e-030.1458image
chr20:33704947-33707196:-HNSCCI.1040EER6.8666e-04-0.1701image
chr20:33704947-33707196:-KICHJNK.Inhibitor.VIIIEER1.5268e-06-0.5596image
ENSG00000101417.10,PXMP4KICHJW.7.52.1EAG2.1547e-070.5912image
chr20:33704947-33707196:-KIRCGSK269962AEER1.3189e-07-0.2846image
ENSG00000101417.10,PXMP4KIRCAUY922EAG6.3755e-06-0.2410image
chr20:33704947-33707196:-KIRPAZD6482EER2.1717e-130.4479image
ENSG00000101417.10,PXMP4KIRPAZD6482EAG6.4565e-120.4197image
ENSG00000101417.10,PXMP4LAMLJW.7.52.1EAG1.1032e-03-0.6137image
chr20:33704947-33707196:-LAMLJW.7.52.1EER1.1032e-03-0.6137image
ENSG00000101417.10,PXMP4LGGJNK.Inhibitor.VIIIEAG9.5482e-050.1719image
chr20:33704947-33707196:-LGGAZD6482EER3.2721e-050.1828image
ENSG00000101417.10,PXMP4LIHCImatinibEAG1.9859e-03-0.1650image
chr20:33704947-33707196:-LIHCBryostatin.1EER2.9240e-04-0.2024image
ENSG00000101417.10,PXMP4LUADAUY922EAG3.1648e-05-0.1889image
chr20:33704947-33707196:-LUADAUY922EER1.7832e-07-0.2375image
chr20:33704947-33707196:-LUSCCCT018159EER2.0755e-07-0.2439image
ENSG00000101417.10,PXMP4LUSCCCT018159EAG3.6243e-05-0.1917image
ENSG00000101417.10,PXMP4MESOBexaroteneEAG5.1934e-03-0.3135image
chr20:33704947-33707196:-MESOGSK269962AEER1.1895e-04-0.4298image
ENSG00000101417.10,PXMP4OVAZ628EAG3.8388e-03-0.1713image
chr20:33704947-33707196:-OVAZD6244EER7.6983e-06-0.2638image
ENSG00000101417.10,PXMP4PAADAZD6482EAG1.8989e-02-0.1914image
chr20:33704947-33707196:-PAADIPA.3EER2.8935e-02-0.1895image
chr20:33704947-33707196:-PCPGJNJ.26854165EER6.7953e-05-0.3246image
ENSG00000101417.10,PXMP4PCPGAP.24534EAG1.6015e-05-0.3421image
ENSG00000101417.10,PXMP4PRADA.770041EAG3.0284e-11-0.2957image
chr20:33704947-33707196:-PRADKU.55933EER3.3536e-14-0.3352image
ENSG00000101417.10,PXMP4READBI.2536EAG5.3773e-060.4499image
chr20:33704947-33707196:-READKU.55933EER2.1546e-04-0.3728image
chr20:33704947-33707196:-SARCCisplatinEER7.8284e-06-0.2894image
ENSG00000101417.10,PXMP4SARCEmbelinEAG6.7697e-05-0.2564image
ENSG00000101417.10,PXMP4SKCMCEP.701EAG1.0467e-05-0.2098image
chr20:33704947-33707196:-SKCMBMS.536924EER3.6942e-06-0.2216image
chr20:33704947-33707196:-STADImatinibEER5.2043e-040.1886image
ENSG00000101417.10,PXMP4STADImatinibEAG1.1367e-030.1755image
ENSG00000101417.10,PXMP4TGCTAZD6482EAG5.6573e-04-0.3053image
chr20:33704947-33707196:-TGCTAP.24534EER3.8249e-020.2176image
chr20:33704947-33707196:-THCACI.1040EER3.9394e-17-0.3694image
ENSG00000101417.10,PXMP4THCACGP.60474EAG9.5308e-12-0.3023image
chr20:33704947-33707196:-THYMCGP.60474EER5.3587e-03-0.2881image
ENSG00000101417.10,PXMP4THYMAZD6482EAG3.4685e-02-0.2158image
chr20:33704947-33707196:-UCECAZD6244EER5.2949e-03-0.2584image
ENSG00000101417.10,PXMP4UCECBI.D1870EAG2.0815e-040.3152image
ENSG00000101417.10,PXMP4UCSFTI.277EAG4.6129e-03-0.4239image
ENSG00000101417.10,PXMP4UVMGSK269962AEAG5.7657e-03-0.3467image
chr20:33704947-33707196:-UVMGSK269962AEER5.7466e-03-0.3469image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType