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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: RASSF1 (ImmuneEditome ID:11186)

1. Gene summary of enriched editing regions for RASSF1

check button Gene summary
Gene informationGene symbol

RASSF1

Gene ID

11186

GeneSynonyms123F2|NORE2A|RASSF1A|RDA32|REH3P21
GeneCytomap

3p21.31

GeneTypeprotein-coding
GeneDescriptionras association domain-containing protein 1|Ras association (RalGDS/AF-6) domain family member 1|WUGSC:H_LUCA12.5|cardiac-specific ras association domain family 1 protein|pancreas-specific ras association domain family 1 protein|tumor suppressor protein RDA32
GeneModificationdate20230329
UniprotIDQ9NS23
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr3:50332494-50333748:-ENST00000327761.6ENSG00000068028.16RASSF1intronicAluSp,AluJo,AluSzchr3:50332494-50333748:-.alignment
chr3:50332494-50333748:-ENST00000357043.5ENSG00000068028.16RASSF1intronicAluSp,AluJo,AluSzchr3:50332494-50333748:-.alignment
chr3:50332494-50333748:-ENST00000359365.7ENSG00000068028.16RASSF1intronicAluSp,AluJo,AluSzchr3:50332494-50333748:-.alignment
chr3:50332494-50333748:-ENST00000395117.5ENSG00000068028.16RASSF1intronicAluSp,AluJo,AluSzchr3:50332494-50333748:-.alignment
chr3:50332494-50333748:-ENST00000395126.6ENSG00000068028.16RASSF1intronicAluSp,AluJo,AluSzchr3:50332494-50333748:-.alignment
chr3:50332494-50333748:-ENST00000482447.1ENSG00000068028.16RASSF1intronicAluSp,AluJo,AluSzchr3:50332494-50333748:-.alignment
chr3:50332494-50333748:-ENST00000616212.3ENSG00000068028.16RASSF1intronicAluSp,AluJo,AluSzchr3:50332494-50333748:-.alignment
chr3:50334973-50336089:-ENST00000327761.6ENSG00000068028.16RASSF1intronicAluSz6,AluSx,AluSg7,AluSzchr3:50334973-50336089:-.alignment
chr3:50334973-50336089:-ENST00000357043.5ENSG00000068028.16RASSF1intronicAluSz6,AluSx,AluSg7,AluSzchr3:50334973-50336089:-.alignment
chr3:50334973-50336089:-ENST00000359365.7ENSG00000068028.16RASSF1intronicAluSz6,AluSx,AluSg7,AluSzchr3:50334973-50336089:-.alignment
chr3:50334973-50336089:-ENST00000395117.5ENSG00000068028.16RASSF1intronicAluSz6,AluSx,AluSg7,AluSzchr3:50334973-50336089:-.alignment
chr3:50334973-50336089:-ENST00000395126.6ENSG00000068028.16RASSF1intronicAluSz6,AluSx,AluSg7,AluSzchr3:50334973-50336089:-.alignment
chr3:50334973-50336089:-ENST00000482447.1ENSG00000068028.16RASSF1intronicAluSz6,AluSx,AluSg7,AluSzchr3:50334973-50336089:-.alignment
chr3:50334973-50336089:-ENST00000616212.3ENSG00000068028.16RASSF1intronicAluSz6,AluSx,AluSg7,AluSzchr3:50334973-50336089:-.alignment


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2. Tumor-specific enriched editing regions for RASSF1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000068028.16,RASSF1LUSCEAG2.4930e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr3:50332494-50333748:-KIRCPathEER2.7047e-034.2519e-040.2158image
ENSG00000068028.16,RASSF1KIRCPathEAG4.6030e-024.9621e-020.1189image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for RASSF1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr3:50334973-50336089:-ESCAEERENSG00000105778,AVL9-0.57352.3734e-061.8327e-09-0.5127imageNBUD13;CELF2;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2NAT_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
chr3:50334973-50336089:-ESCAEERENSG00000107643,MAPK8-0.53489.0691e-061.1796e-06-0.4250imageNBUD13;CELF2;CPSF6;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184MAPK8T_cells_regulatory_(Tregs)GSVA_HALLMARK_P53_PATHWAY
chr3:50334973-50336089:-ESCAEERENSG00000197183,NOL4L-0.51792.8760e-051.3783e-06-0.4226imageNBUD13;CELF2;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr3:50334973-50336089:-ESCAEERENSG00000226330,RP11-739N20.2-0.50893.0564e-053.6681e-08-0.4751imageNEIF4A3;FUS;HNRNPA1;HNRNPC;NOP56;NOP58;SRSF1;TAF15;U2AF2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr3:50334973-50336089:-ESCAEERENSG00000167861,HID1-0.49893.6586e-052.4340e-06-0.4135imageNBUD13;CSTF2T;DGCR8;EIF4A3;FAM120A;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPUL1;IGF2BP1;LIN28;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr3:50334973-50336089:-ESCAEERENSG00000168237,GLYCTK-0.51084.1372e-053.9297e-06-0.4056imageNBUD13;CELF2;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;LIN28;LSM11;NONO;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;U2AF1;U2AF2;XRN2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:50334973-50336089:-ESCAEERENSG00000204149,AGAP6-0.51075.2942e-053.4477e-07-0.4437imageNBUD13;CPSF6;CSTF2T;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184NAB_cells_naiveGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr3:50334973-50336089:-ESCAEERENSG00000227719,AC006042.6-0.47915.5627e-051.7996e-07-0.4531imageNEIF4A3;FUS;NOP58;TAF15NAB_cells_naiveGSVA_HALLMARK_APICAL_SURFACE
chr3:50334973-50336089:-ESCAEERENSG00000174233,ADCY6-0.49695.9535e-052.9853e-07-0.4458imageNBUD13;CSTF2T;DGCR8;EIF4A3;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;LIN28;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;U2AF1;U2AF2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:50334973-50336089:-ESCAEERENSG00000143375,CGN-0.49506.7149e-052.8476e-07-0.4465imageNBUD13;CSTF2T;DGCR8;EIF4A3;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;LIN28;NOP56;NOP58;PCBP2;PRPF8;RANGAP1;RBFOX2;SRSF1;TAF15;U2AF2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:50334973-50336089:-ESCAEERENSG00000105778,AVL9-0.57352.3734e-061.8327e-09-0.5127imageNBUD13;CELF2;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2NAT_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
chr3:50334973-50336089:-ESCAEERENSG00000107643,MAPK8-0.53489.0691e-061.1796e-06-0.4250imageNBUD13;CELF2;CPSF6;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184MAPK8T_cells_regulatory_(Tregs)GSVA_HALLMARK_P53_PATHWAY
chr3:50334973-50336089:-ESCAEERENSG00000197183,NOL4L-0.51792.8760e-051.3783e-06-0.4226imageNBUD13;CELF2;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr3:50334973-50336089:-ESCAEERENSG00000226330,RP11-739N20.2-0.50893.0564e-053.6681e-08-0.4751imageNEIF4A3;FUS;HNRNPA1;HNRNPC;NOP56;NOP58;SRSF1;TAF15;U2AF2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr3:50334973-50336089:-ESCAEERENSG00000167861,HID1-0.49893.6586e-052.4340e-06-0.4135imageNBUD13;CSTF2T;DGCR8;EIF4A3;FAM120A;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPUL1;IGF2BP1;LIN28;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr3:50334973-50336089:-ESCAEERENSG00000168237,GLYCTK-0.51084.1372e-053.9297e-06-0.4056imageNBUD13;CELF2;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;LIN28;LSM11;NONO;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;U2AF1;U2AF2;XRN2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:50334973-50336089:-ESCAEERENSG00000204149,AGAP6-0.51075.2942e-053.4477e-07-0.4437imageNBUD13;CPSF6;CSTF2T;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184NAB_cells_naiveGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr3:50334973-50336089:-ESCAEERENSG00000227719,AC006042.6-0.47915.5627e-051.7996e-07-0.4531imageNEIF4A3;FUS;NOP58;TAF15NAB_cells_naiveGSVA_HALLMARK_APICAL_SURFACE
chr3:50334973-50336089:-ESCAEERENSG00000174233,ADCY6-0.49695.9535e-052.9853e-07-0.4458imageNBUD13;CSTF2T;DGCR8;EIF4A3;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;LIN28;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;U2AF1;U2AF2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:50334973-50336089:-ESCAEERENSG00000143375,CGN-0.49506.7149e-052.8476e-07-0.4465imageNBUD13;CSTF2T;DGCR8;EIF4A3;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;LIN28;NOP56;NOP58;PCBP2;PRPF8;RANGAP1;RBFOX2;SRSF1;TAF15;U2AF2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:50334973-50336089:-ESCAEERENSG00000105778,AVL9-0.57352.3734e-061.8327e-09-0.5127imageNBUD13;CELF2;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2NAT_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
chr3:50334973-50336089:-ESCAEERENSG00000107643,MAPK8-0.53489.0691e-061.1796e-06-0.4250imageNBUD13;CELF2;CPSF6;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184MAPK8T_cells_regulatory_(Tregs)GSVA_HALLMARK_P53_PATHWAY
chr3:50334973-50336089:-ESCAEERENSG00000197183,NOL4L-0.51792.8760e-051.3783e-06-0.4226imageNBUD13;CELF2;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr3:50334973-50336089:-ESCAEERENSG00000226330,RP11-739N20.2-0.50893.0564e-053.6681e-08-0.4751imageNEIF4A3;FUS;HNRNPA1;HNRNPC;NOP56;NOP58;SRSF1;TAF15;U2AF2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr3:50334973-50336089:-ESCAEERENSG00000167861,HID1-0.49893.6586e-052.4340e-06-0.4135imageNBUD13;CSTF2T;DGCR8;EIF4A3;FAM120A;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPUL1;IGF2BP1;LIN28;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr3:50334973-50336089:-ESCAEERENSG00000168237,GLYCTK-0.51084.1372e-053.9297e-06-0.4056imageNBUD13;CELF2;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;LIN28;LSM11;NONO;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;U2AF1;U2AF2;XRN2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:50334973-50336089:-ESCAEERENSG00000204149,AGAP6-0.51075.2942e-053.4477e-07-0.4437imageNBUD13;CPSF6;CSTF2T;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184NAB_cells_naiveGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr3:50334973-50336089:-ESCAEERENSG00000227719,AC006042.6-0.47915.5627e-051.7996e-07-0.4531imageNEIF4A3;FUS;NOP58;TAF15NAB_cells_naiveGSVA_HALLMARK_APICAL_SURFACE
chr3:50334973-50336089:-ESCAEERENSG00000174233,ADCY6-0.49695.9535e-052.9853e-07-0.4458imageNBUD13;CSTF2T;DGCR8;EIF4A3;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;LIN28;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;U2AF1;U2AF2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:50334973-50336089:-ESCAEERENSG00000143375,CGN-0.49506.7149e-052.8476e-07-0.4465imageNBUD13;CSTF2T;DGCR8;EIF4A3;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;LIN28;NOP56;NOP58;PCBP2;PRPF8;RANGAP1;RBFOX2;SRSF1;TAF15;U2AF2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:50334973-50336089:-ESCAEERENSG00000105778,AVL9-0.57352.3734e-061.8327e-09-0.5127imageNBUD13;CELF2;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2NAT_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
chr3:50334973-50336089:-ESCAEERENSG00000107643,MAPK8-0.53489.0691e-061.1796e-06-0.4250imageNBUD13;CELF2;CPSF6;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184MAPK8T_cells_regulatory_(Tregs)GSVA_HALLMARK_P53_PATHWAY
chr3:50334973-50336089:-ESCAEERENSG00000197183,NOL4L-0.51792.8760e-051.3783e-06-0.4226imageNBUD13;CELF2;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr3:50334973-50336089:-ESCAEERENSG00000226330,RP11-739N20.2-0.50893.0564e-053.6681e-08-0.4751imageNEIF4A3;FUS;HNRNPA1;HNRNPC;NOP56;NOP58;SRSF1;TAF15;U2AF2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr3:50334973-50336089:-ESCAEERENSG00000167861,HID1-0.49893.6586e-052.4340e-06-0.4135imageNBUD13;CSTF2T;DGCR8;EIF4A3;FAM120A;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPUL1;IGF2BP1;LIN28;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr3:50334973-50336089:-ESCAEERENSG00000168237,GLYCTK-0.51084.1372e-053.9297e-06-0.4056imageNBUD13;CELF2;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;LIN28;LSM11;NONO;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;U2AF1;U2AF2;XRN2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:50334973-50336089:-ESCAEERENSG00000204149,AGAP6-0.51075.2942e-053.4477e-07-0.4437imageNBUD13;CPSF6;CSTF2T;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184NAB_cells_naiveGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr3:50334973-50336089:-ESCAEERENSG00000227719,AC006042.6-0.47915.5627e-051.7996e-07-0.4531imageNEIF4A3;FUS;NOP58;TAF15NAB_cells_naiveGSVA_HALLMARK_APICAL_SURFACE
chr3:50334973-50336089:-ESCAEERENSG00000174233,ADCY6-0.49695.9535e-052.9853e-07-0.4458imageNBUD13;CSTF2T;DGCR8;EIF4A3;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;LIN28;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;U2AF1;U2AF2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:50334973-50336089:-ESCAEERENSG00000143375,CGN-0.49506.7149e-052.8476e-07-0.4465imageNBUD13;CSTF2T;DGCR8;EIF4A3;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;LIN28;NOP56;NOP58;PCBP2;PRPF8;RANGAP1;RBFOX2;SRSF1;TAF15;U2AF2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:50334973-50336089:-ESCAEERENSG00000105778,AVL9-0.57352.3734e-061.8327e-09-0.5127imageNBUD13;CELF2;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2NAT_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
chr3:50334973-50336089:-ESCAEERENSG00000107643,MAPK8-0.53489.0691e-061.1796e-06-0.4250imageNBUD13;CELF2;CPSF6;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184MAPK8T_cells_regulatory_(Tregs)GSVA_HALLMARK_P53_PATHWAY
chr3:50334973-50336089:-ESCAEERENSG00000197183,NOL4L-0.51792.8760e-051.3783e-06-0.4226imageNBUD13;CELF2;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr3:50334973-50336089:-ESCAEERENSG00000226330,RP11-739N20.2-0.50893.0564e-053.6681e-08-0.4751imageNEIF4A3;FUS;HNRNPA1;HNRNPC;NOP56;NOP58;SRSF1;TAF15;U2AF2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr3:50334973-50336089:-ESCAEERENSG00000167861,HID1-0.49893.6586e-052.4340e-06-0.4135imageNBUD13;CSTF2T;DGCR8;EIF4A3;FAM120A;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPUL1;IGF2BP1;LIN28;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr3:50334973-50336089:-ESCAEERENSG00000168237,GLYCTK-0.51084.1372e-053.9297e-06-0.4056imageNBUD13;CELF2;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;LIN28;LSM11;NONO;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;U2AF1;U2AF2;XRN2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:50334973-50336089:-ESCAEERENSG00000204149,AGAP6-0.51075.2942e-053.4477e-07-0.4437imageNBUD13;CPSF6;CSTF2T;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184NAB_cells_naiveGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr3:50334973-50336089:-ESCAEERENSG00000227719,AC006042.6-0.47915.5627e-051.7996e-07-0.4531imageNEIF4A3;FUS;NOP58;TAF15NAB_cells_naiveGSVA_HALLMARK_APICAL_SURFACE
chr3:50334973-50336089:-ESCAEERENSG00000174233,ADCY6-0.49695.9535e-052.9853e-07-0.4458imageNBUD13;CSTF2T;DGCR8;EIF4A3;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;LIN28;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;U2AF1;U2AF2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:50334973-50336089:-ESCAEERENSG00000143375,CGN-0.49506.7149e-052.8476e-07-0.4465imageNBUD13;CSTF2T;DGCR8;EIF4A3;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;LIN28;NOP56;NOP58;PCBP2;PRPF8;RANGAP1;RBFOX2;SRSF1;TAF15;U2AF2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:50334973-50336089:-ESCAEERENSG00000105778,AVL9-0.57352.3734e-061.8327e-09-0.5127imageNBUD13;CELF2;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2NAT_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
chr3:50334973-50336089:-ESCAEERENSG00000107643,MAPK8-0.53489.0691e-061.1796e-06-0.4250imageNBUD13;CELF2;CPSF6;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184MAPK8T_cells_regulatory_(Tregs)GSVA_HALLMARK_P53_PATHWAY
chr3:50334973-50336089:-ESCAEERENSG00000197183,NOL4L-0.51792.8760e-051.3783e-06-0.4226imageNBUD13;CELF2;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr3:50334973-50336089:-ESCAEERENSG00000226330,RP11-739N20.2-0.50893.0564e-053.6681e-08-0.4751imageNEIF4A3;FUS;HNRNPA1;HNRNPC;NOP56;NOP58;SRSF1;TAF15;U2AF2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr3:50334973-50336089:-ESCAEERENSG00000167861,HID1-0.49893.6586e-052.4340e-06-0.4135imageNBUD13;CSTF2T;DGCR8;EIF4A3;FAM120A;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPUL1;IGF2BP1;LIN28;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr3:50334973-50336089:-ESCAEERENSG00000168237,GLYCTK-0.51084.1372e-053.9297e-06-0.4056imageNBUD13;CELF2;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;LIN28;LSM11;NONO;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;U2AF1;U2AF2;XRN2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:50334973-50336089:-ESCAEERENSG00000204149,AGAP6-0.51075.2942e-053.4477e-07-0.4437imageNBUD13;CPSF6;CSTF2T;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184NAB_cells_naiveGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr3:50334973-50336089:-ESCAEERENSG00000227719,AC006042.6-0.47915.5627e-051.7996e-07-0.4531imageNEIF4A3;FUS;NOP58;TAF15NAB_cells_naiveGSVA_HALLMARK_APICAL_SURFACE
chr3:50334973-50336089:-ESCAEERENSG00000174233,ADCY6-0.49695.9535e-052.9853e-07-0.4458imageNBUD13;CSTF2T;DGCR8;EIF4A3;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;LIN28;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;U2AF1;U2AF2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:50334973-50336089:-ESCAEERENSG00000143375,CGN-0.49506.7149e-052.8476e-07-0.4465imageNBUD13;CSTF2T;DGCR8;EIF4A3;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;LIN28;NOP56;NOP58;PCBP2;PRPF8;RANGAP1;RBFOX2;SRSF1;TAF15;U2AF2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:50334973-50336089:-ESCAEERENSG00000105778,AVL9-0.57352.3734e-061.8327e-09-0.5127imageNBUD13;CELF2;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2NAT_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
chr3:50334973-50336089:-ESCAEERENSG00000107643,MAPK8-0.53489.0691e-061.1796e-06-0.4250imageNBUD13;CELF2;CPSF6;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184MAPK8T_cells_regulatory_(Tregs)GSVA_HALLMARK_P53_PATHWAY
chr3:50334973-50336089:-ESCAEERENSG00000197183,NOL4L-0.51792.8760e-051.3783e-06-0.4226imageNBUD13;CELF2;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr3:50334973-50336089:-ESCAEERENSG00000226330,RP11-739N20.2-0.50893.0564e-053.6681e-08-0.4751imageNEIF4A3;FUS;HNRNPA1;HNRNPC;NOP56;NOP58;SRSF1;TAF15;U2AF2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr3:50334973-50336089:-ESCAEERENSG00000167861,HID1-0.49893.6586e-052.4340e-06-0.4135imageNBUD13;CSTF2T;DGCR8;EIF4A3;FAM120A;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPUL1;IGF2BP1;LIN28;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr3:50334973-50336089:-ESCAEERENSG00000168237,GLYCTK-0.51084.1372e-053.9297e-06-0.4056imageNBUD13;CELF2;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;LIN28;LSM11;NONO;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;U2AF1;U2AF2;XRN2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:50334973-50336089:-ESCAEERENSG00000204149,AGAP6-0.51075.2942e-053.4477e-07-0.4437imageNBUD13;CPSF6;CSTF2T;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184NAB_cells_naiveGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr3:50334973-50336089:-ESCAEERENSG00000227719,AC006042.6-0.47915.5627e-051.7996e-07-0.4531imageNEIF4A3;FUS;NOP58;TAF15NAB_cells_naiveGSVA_HALLMARK_APICAL_SURFACE
chr3:50334973-50336089:-ESCAEERENSG00000174233,ADCY6-0.49695.9535e-052.9853e-07-0.4458imageNBUD13;CSTF2T;DGCR8;EIF4A3;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;LIN28;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;U2AF1;U2AF2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:50334973-50336089:-ESCAEERENSG00000143375,CGN-0.49506.7149e-052.8476e-07-0.4465imageNBUD13;CSTF2T;DGCR8;EIF4A3;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;LIN28;NOP56;NOP58;PCBP2;PRPF8;RANGAP1;RBFOX2;SRSF1;TAF15;U2AF2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM

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4. Enriched editing regions and immune related splicing for RASSF1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr3:50334973-50336089:-
ESCAEERMEXENSG00000026508.12chr1135190014:35190065:35201081:35201195:35209964:35210054:35214851:352148610.44492.1071e-031.2717e-070.4633imageNCSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;HNRNPA1;HNRNPC;HNRNPU;IGF2BP1;ILF3;KHDRBS1;NONO;NOP56;NOP58;PTBP1;RBFOX2;SAFB2;SLTM;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF2;ZNF184CD44Dendritic_cells_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
chr3:50334973-50336089:-
ESCAEERIRENSG00000054654.11chr1464214143:64214470:64215285:64215354-0.41655.0568e-031.5818e-06-0.4220imageNBUD13;CELF2;CSTF2T;DGCR8;EIF4A3;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;LIN28;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_KRAS_SIGNALING_DN
ENSG00000068028.16,RASSF1
ESCAEAGMEXENSG00000182473.16chr1776089174:76089320:76090328:76090459:76091142:76091272:76094413:76094489-0.38071.3668e-027.7555e-08-0.4352imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184EXOC7Macrophages_M2GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr3:50334973-50336089:-
ESCAEERIRENSG00000178927.12chr1782445250:82445960:82446622:82446663-0.43916.6260e-033.1813e-06-0.4091imageNBUD13;CELF2;CPSF6;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_APICAL_SURFACE
chr3:50334973-50336089:-
ESCAEERIRENSG00000157916.14chr12395607:2395648:2395783:2395871-0.35084.9573e-024.6257e-07-0.4570imageNBUD13;CELF2;CPSF6;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING
chr3:50334973-50336089:-
ESCAEERIRENSG00000125901.5chr203046613:3046900:3047734:3048254-0.34432.3334e-024.2780e-05-0.4130imageNBUD13;CELF2;CPSF6;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;KHDRBS1;LIN28;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr3:50334973-50336089:-
ESCAEERIRENSG00000142733.10chr127364203:27364394:27364660:27364684-0.37603.3549e-027.8840e-06-0.4000imageNBUD13;CPSF6;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPK;HNRNPU;IGF2BP1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TROVE2;U2AF1;U2AF2;XRN2;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_APICAL_SURFACE
chr3:50334973-50336089:-
ESCAEERIRENSG00000186501.10chr127334150:27334754:27335378:27335648-0.32314.1481e-023.6772e-05-0.4250imageNBUD13;CELF2;CPSF6;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184NANeutrophilsGSVA_HALLMARK_GLYCOLYSIS
chr3:50334973-50336089:-
ESCAEERIRENSG00000213928.4chr1424164062:24164134:24164586:24164739-0.37654.1493e-025.2492e-07-0.4391imageNBUD13;CELF2;CPSF6;CSTF2T;DGCR8;EIF4A3;EIF4G2;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;ILF3;KHDRBS1;LIN28;LSM11;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SAFB2;SF3A3;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;TROVE2;U2AF1;U2AF2;XRN2;ZNF184IRF9T_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING
chr3:50334973-50336089:-
ESCAEERIRENSG00000182327.7chr174788958:4789677:4789758:47903900.33571.0433e-022.2366e-050.4309imageNBUD13;CSTF2T;EIF4A3;FAM120A;FUS;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPU;IGF2BP1;PCBP2;PRPF8;RBFOX2;SF3A3;SMNDC1;SRSF1;SRSF9;TAF15;U2AF1;U2AF2NADendritic_cells_restingGSVA_HALLMARK_KRAS_SIGNALING_DN

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5. Enriched editing regions and immune infiltration for RASSF1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000068028.16,RASSF1BLCAEAGNeutrophils4.5742e-030.2842image
chr3:50332494-50333748:-BRCAEERT_cells_gamma_delta5.9322e-030.1239image
chr3:50334973-50336089:-BRCAEERNK_cells_resting9.5834e-030.1905image
ENSG00000068028.16,RASSF1BRCAEAGT_cells_CD82.0691e-02-0.1007image
ENSG00000068028.16,RASSF1CESCEAGT_cells_follicular_helper2.2024e-020.1706image
chr3:50332494-50333748:-COADEERT_cells_gamma_delta2.4983e-020.2137image
ENSG00000068028.16,RASSF1COADEAGT_cells_gamma_delta1.7707e-020.2218image
ENSG00000068028.16,RASSF1DLBCEAGT_cells_gamma_delta4.9669e-02-0.3615image
chr3:50332494-50333748:-ESCAEERT_cells_CD4_memory_resting8.9968e-06-0.4059image
chr3:50334973-50336089:-ESCAEERT_cells_gamma_delta2.7985e-040.3247image
ENSG00000068028.16,RASSF1ESCAEAGMast_cells_resting9.7748e-050.3233image
chr3:50332494-50333748:-GBMEERT_cells_CD4_naive4.4618e-02-0.2671image
chr3:50332494-50333748:-HNSCEERT_cells_gamma_delta8.5501e-030.3452image
chr3:50332494-50333748:-KIRCEERDendritic_cells_activated1.2926e-040.2894image
chr3:50334973-50336089:-KIRCEERT_cells_regulatory_(Tregs)5.1547e-030.2909image
ENSG00000068028.16,RASSF1KIRCEAGDendritic_cells_activated5.3760e-070.3682image
chr3:50332494-50333748:-KIRPEERMast_cells_resting2.4187e-020.3394image
ENSG00000068028.16,RASSF1KIRPEAGMast_cells_resting1.5307e-020.3315image
chr3:50332494-50333748:-LAMLEERT_cells_CD4_memory_activated6.6284e-040.2749image
chr3:50334973-50336089:-LAMLEERNK_cells_activated4.5477e-020.1712image
ENSG00000068028.16,RASSF1LAMLEAGT_cells_CD4_memory_activated4.4608e-030.2310image
ENSG00000068028.16,RASSF1LGGEAGMast_cells_activated2.7547e-020.2693image
chr3:50332494-50333748:-LUADEERMonocytes3.4666e-020.1379image
chr3:50334973-50336089:-LUADEERB_cells_memory2.1997e-02-0.2173image
ENSG00000068028.16,RASSF1LUSCEAGNK_cells_activated2.7284e-020.1598image
chr3:50332494-50333748:-MESOEERMast_cells_activated1.3040e-030.5963image
ENSG00000068028.16,RASSF1MESOEAGT_cells_follicular_helper2.2649e-020.4370image
ENSG00000068028.16,RASSF1OVEAGMacrophages_M14.9931e-020.1484image
chr3:50334973-50336089:-PAADEERDendritic_cells_activated3.9213e-03-0.5458image
chr3:50332494-50333748:-PRADEERT_cells_gamma_delta1.6684e-020.2915image
chr3:50332494-50333748:-SARCEERT_cells_regulatory_(Tregs)1.5924e-020.2254image
ENSG00000068028.16,RASSF1SARCEAGT_cells_regulatory_(Tregs)2.3368e-030.2731image
chr3:50332494-50333748:-SKCMEERNK_cells_activated3.9239e-030.2381image
ENSG00000068028.16,RASSF1SKCMEAGNK_cells_activated5.1397e-030.2237image
chr3:50332494-50333748:-STADEERB_cells_naive7.0137e-04-0.2299image
chr3:50334973-50336089:-STADEERMacrophages_M17.8436e-050.2685image
ENSG00000068028.16,RASSF1STADEAGMacrophages_M16.0565e-040.2125image
chr3:50332494-50333748:-TGCTEERT_cells_CD4_memory_resting3.3234e-020.2513image
ENSG00000068028.16,RASSF1TGCTEAGT_cells_CD4_memory_resting3.2993e-020.2499image
ENSG00000068028.16,RASSF1UCECEAGNK_cells_activated6.4608e-030.5201image


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6. Enriched editing regions and immune gene sets for RASSF1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
ENSG00000068028.16,RASSF1BRCAEAG3.2621e-02image2.6266e-020.0967image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000068028.16,RASSF1BLCAGSVA_HALLMARK_ANGIOGENESISEAG1.0064e-030.3272image
chr3:50332494-50333748:-BRCAGSVA_HALLMARK_GLYCOLYSISEER4.8691e-070.2245image
chr3:50334973-50336089:-BRCAGSVA_HALLMARK_GLYCOLYSISEER1.2430e-040.2792image
ENSG00000068028.16,RASSF1BRCAGSVA_HALLMARK_GLYCOLYSISEAG1.8095e-070.2247image
chr3:50332494-50333748:-COADGSVA_HALLMARK_P53_PATHWAYEER2.8759e-02-0.2086image
ENSG00000068028.16,RASSF1DLBCGSVA_HALLMARK_SPERMATOGENESISEAG2.4660e-020.4094image
chr3:50332494-50333748:-DLBCGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.7144e-040.7052image
ENSG00000068028.16,RASSF1ESCAGSVA_HALLMARK_MYOGENESISEAG9.6263e-040.2760image
chr3:50332494-50333748:-ESCAGSVA_HALLMARK_MYOGENESISEER1.0985e-040.3573image
chr3:50334973-50336089:-ESCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER4.7951e-030.2548image
chr3:50332494-50333748:-GBMGSVA_HALLMARK_ADIPOGENESISEER4.7246e-030.3691image
ENSG00000068028.16,RASSF1GBMGSVA_HALLMARK_IL2_STAT5_SIGNALINGEAG3.7432e-030.3687image
chr3:50332494-50333748:-HNSCGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.4589e-030.4118image
chr3:50334973-50336089:-KIRCGSVA_HALLMARK_UV_RESPONSE_DNEER5.8284e-03-0.2869image
chr3:50332494-50333748:-KIRCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER4.4056e-03-0.2174image
ENSG00000068028.16,RASSF1KIRCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG6.3105e-03-0.2057image
chr3:50332494-50333748:-KIRPGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.2188e-020.3748image
ENSG00000068028.16,RASSF1KIRPGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG3.3336e-030.3960image
chr3:50334973-50336089:-KIRPGSVA_HALLMARK_SPERMATOGENESISEER8.1449e-030.5490image
chr3:50334973-50336089:-LAMLGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER2.8505e-03-0.2530image
ENSG00000068028.16,RASSF1LAMLGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.4892e-02-0.1985image
chr3:50332494-50333748:-LAMLGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2137e-030.2618image
ENSG00000068028.16,RASSF1LUADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.7430e-040.2405image
chr3:50334973-50336089:-LUADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER7.1742e-030.2539image
chr3:50332494-50333748:-LUADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER5.9609e-040.2223image
chr3:50332494-50333748:-LUSCGSVA_HALLMARK_PEROXISOMEEER6.1044e-040.2510image
ENSG00000068028.16,RASSF1LUSCGSVA_HALLMARK_PEROXISOMEEAG2.0888e-030.2214image
ENSG00000068028.16,RASSF1MESOGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG6.5192e-030.5104image
chr3:50334973-50336089:-OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.0048e-030.3108image
ENSG00000068028.16,RASSF1OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG5.5400e-040.2584image
chr3:50332494-50333748:-OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEER3.3189e-040.2920image
chr3:50332494-50333748:-PAADGSVA_HALLMARK_GLYCOLYSISEER3.2350e-020.2310image
ENSG00000068028.16,RASSF1PAADGSVA_HALLMARK_COAGULATIONEAG4.9979e-020.2073image
chr3:50334973-50336089:-PAADGSVA_HALLMARK_BILE_ACID_METABOLISMEER2.9237e-020.4278image
chr3:50332494-50333748:-READGSVA_HALLMARK_SPERMATOGENESISEER4.1537e-02-0.3323image
ENSG00000068028.16,RASSF1READGSVA_HALLMARK_SPERMATOGENESISEAG4.5458e-02-0.3142image
ENSG00000068028.16,RASSF1SARCGSVA_HALLMARK_DNA_REPAIREAG1.5197e-020.2194image
chr3:50332494-50333748:-SARCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER3.1150e-020.2020image
ENSG00000068028.16,RASSF1SKCMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.6002e-030.2514image
chr3:50332494-50333748:-SKCMGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.2464e-020.2070image
ENSG00000068028.16,RASSF1STADGSVA_HALLMARK_APOPTOSISEAG1.6729e-030.1951image
chr3:50334973-50336089:-STADGSVA_HALLMARK_SPERMATOGENESISEER3.0239e-040.2464image
chr3:50332494-50333748:-STADGSVA_HALLMARK_APOPTOSISEER1.2398e-040.2594image
chr3:50332494-50333748:-TGCTGSVA_HALLMARK_FATTY_ACID_METABOLISMEER2.1423e-020.2708image
ENSG00000068028.16,RASSF1TGCTGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG1.2458e-020.2911image
ENSG00000068028.16,RASSF1THCAGSVA_HALLMARK_PEROXISOMEEAG4.5043e-020.2084image
ENSG00000068028.16,RASSF1THYMGSVA_HALLMARK_ANDROGEN_RESPONSEEAG6.5035e-030.4453image


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7. Enriched editing regions and drugs for RASSF1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000068028.16,RASSF1BLCACGP.60474EAG2.9616e-03-0.2972image
chr3:50334973-50336089:-BRCALapatinibEER2.8162e-02-0.1627image
ENSG00000068028.16,RASSF1BRCAKIN001.135EAG7.4345e-04-0.1463image
chr3:50332494-50333748:-BRCAAS601245EER2.7818e-030.1346image
ENSG00000068028.16,RASSF1CESCGefitinibEAG4.5842e-04-0.2585image
chr3:50332494-50333748:-COADElesclomolEER1.1262e-030.3065image
ENSG00000068028.16,RASSF1COADElesclomolEAG1.0258e-030.3036image
chr3:50332494-50333748:-DLBCAMG.706EER4.6890e-03-0.5680image
ENSG00000068028.16,RASSF1DLBCMG.132EAG7.6251e-030.4775image
chr3:50334973-50336089:-ESCACCT018159EER1.8897e-06-0.4192image
ENSG00000068028.16,RASSF1ESCAGNF.2EAG1.4623e-06-0.3940image
chr3:50332494-50333748:-ESCAAZD.0530EER1.3459e-11-0.5843image
ENSG00000068028.16,RASSF1GBMErlotinibEAG3.3720e-03-0.3726image
chr3:50332494-50333748:-GBMErlotinibEER9.0242e-04-0.4278image
chr3:50332494-50333748:-HNSCJNJ.26854165EER1.3049e-03-0.4156image
ENSG00000068028.16,RASSF1HNSCAZD.0530EAG3.4437e-04-0.4435image
chr3:50334973-50336089:-KIRCEmbelinEER6.3921e-040.3513image
ENSG00000068028.16,RASSF1KIRCBexaroteneEAG4.5600e-040.2622image
chr3:50332494-50333748:-KIRCJNK.9LEER2.7002e-050.3160image
chr3:50332494-50333748:-KIRPCyclopamineEER4.1091e-03-0.4242image
chr3:50334973-50336089:-KIRPErlotinibEER1.3234e-02-0.5194image
ENSG00000068028.16,RASSF1KIRPErlotinibEAG3.3303e-03-0.3960image
ENSG00000068028.16,RASSF1LAMLATRAEAG9.5093e-040.2671image
chr3:50334973-50336089:-LAMLGemcitabineEER6.9098e-040.2864image
chr3:50332494-50333748:-LAMLCCT018159EER2.0744e-040.2985image
ENSG00000068028.16,RASSF1LGGBleomycinEAG2.4105e-030.3647image
chr3:50334973-50336089:-LUADBryostatin.1EER1.6921e-03-0.2947image
chr3:50332494-50333748:-LUADJNK.9LEER1.7081e-020.1555image
ENSG00000068028.16,RASSF1LUADJNK.9LEAG1.2515e-020.1613image
chr3:50332494-50333748:-LUSCJNJ.26854165EER2.3025e-03-0.2240image
ENSG00000068028.16,RASSF1LUSCCMKEAG2.2598e-02-0.1649image
chr3:50332494-50333748:-MESOBMS.708163EER3.2192e-020.4210image
ENSG00000068028.16,RASSF1MESOGDC0941EAG2.6764e-030.5547image
chr3:50332494-50333748:-OVBMS.708163EER1.6713e-02-0.1971image
chr3:50334973-50336089:-OVGW.441756EER8.0128e-04-0.3164image
ENSG00000068028.16,RASSF1OVMG.132EAG3.2320e-02-0.1624image
chr3:50334973-50336089:-PAADBleomycinEER5.4913e-030.5287image
ENSG00000068028.16,RASSF1PAADA.770041EAG3.9502e-02-0.2175image
chr3:50332494-50333748:-PAADA.770041EER1.2094e-02-0.2695image
ENSG00000068028.16,RASSF1PRADCCT018159EAG2.4768e-080.5808image
chr3:50332494-50333748:-PRADCCT018159EER7.8318e-080.6004image
ENSG00000068028.16,RASSF1READCisplatinEAG1.1833e-020.3895image
chr3:50332494-50333748:-SARCKIN001.135EER2.6445e-030.2790image
ENSG00000068028.16,RASSF1SKCMGDC0941EAG1.0609e-02-0.2054image
chr3:50332494-50333748:-SKCMGDC0941EER1.8652e-02-0.1958image
chr3:50334973-50336089:-STADGemcitabineEER2.2939e-04-0.2510image
ENSG00000068028.16,RASSF1STADBMS.509744EAG1.2849e-04-0.2366image
chr3:50332494-50333748:-STADBMS.509744EER2.6704e-03-0.2043image
ENSG00000068028.16,RASSF1TGCTIPA.3EAG3.7530e-02-0.2440image
ENSG00000068028.16,RASSF1THCADocetaxelEAG7.6047e-03-0.2751image
chr3:50332494-50333748:-THCALFM.A13EER2.4182e-02-0.2488image
chr3:50332494-50333748:-THYMABT.888EER9.6939e-030.4374image
ENSG00000068028.16,RASSF1THYMABT.888EAG7.6950e-040.5352image
ENSG00000068028.16,RASSF1UCECABT.888EAG3.0929e-030.5574image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType