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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: WDR6 (ImmuneEditome ID:11180)

1. Gene summary of enriched editing regions for WDR6

check button Gene summary
Gene informationGene symbol

WDR6

Gene ID

11180

GeneSynonymsTrm734
GeneCytomap

3p21.31

GeneTypeprotein-coding
GeneDescriptionWD repeat-containing protein 6|Trm734 homolog
GeneModificationdate20230409
UniprotIDA0A087X295;Q9NNW5;F8WE36;V9GZ65;E9PDU5;E5RFX3;E9PBK6;C9K020;V9GYU1;V9GZ48;C9JFP6
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr3:49008926-49011498:+ENST00000420783.6ENSG00000178252.16WDR6exonic(C)n,AluSx1,AluY,L2c,(TTTTCA)n,AluSx,Alu,AluJb,(T)n,(TGACTGA)n,MER20chr3:49008926-49011498:+.alignment
chr3:49008926-49011498:+ENST00000438660.4ENSG00000178252.16WDR6exonic(C)n,AluSx1,AluY,L2c,(TTTTCA)n,AluSx,Alu,AluJb,(T)n,(TGACTGA)n,MER20chr3:49008926-49011498:+.alignment
chr3:49008926-49011498:+ENST00000452875.4ENSG00000178252.16WDR6exonic(C)n,AluSx1,AluY,L2c,(TTTTCA)n,AluSx,Alu,AluJb,(T)n,(TGACTGA)n,MER20chr3:49008926-49011498:+.alignment
chr3:49008926-49011498:+ENST00000627177.1ENSG00000178252.16WDR6exonic(C)n,AluSx1,AluY,L2c,(TTTTCA)n,AluSx,Alu,AluJb,(T)n,(TGACTGA)n,MER20chr3:49008926-49011498:+.alignment


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2. Tumor-specific enriched editing regions for WDR6


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr3:49008926-49011498:+BRCAEER4.0452e-03image
ENSG00000178252.16,WDR6BRCAEAG4.0938e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for WDR6


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for WDR6


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for WDR6


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr3:49008926-49011498:+BLCAEERMonocytes4.9060e-02-0.2396image
ENSG00000178252.16,WDR6BLCAEAGMonocytes4.9060e-02-0.2396image
chr3:49008926-49011498:+BRCAEERT_cells_CD4_memory_resting1.1694e-020.1328image
ENSG00000178252.16,WDR6BRCAEAGT_cells_CD4_memory_resting1.3367e-020.1301image
chr3:49008926-49011498:+CESCEERMast_cells_resting3.9649e-030.4257image
ENSG00000178252.16,WDR6CESCEAGMast_cells_resting1.3970e-020.3640image
chr3:49008926-49011498:+ESCAEERT_cells_CD4_naive3.5061e-02-0.2524image
ENSG00000178252.16,WDR6ESCAEAGT_cells_CD4_naive3.6469e-02-0.2505image
chr3:49008926-49011498:+GBMEERT_cells_CD4_memory_resting3.5307e-020.2616image
ENSG00000178252.16,WDR6GBMEAGT_cells_CD4_memory_resting3.5307e-020.2616image
chr3:49008926-49011498:+KIRPEERMacrophages_M14.6164e-020.2923image
ENSG00000178252.16,WDR6KIRPEAGMacrophages_M14.6164e-020.2923image
chr3:49008926-49011498:+LUADEEREosinophils8.5279e-030.1879image
ENSG00000178252.16,WDR6LUADEAGEosinophils8.4806e-030.1880image
chr3:49008926-49011498:+OVEERMast_cells_activated5.7690e-030.2267image
ENSG00000178252.16,WDR6OVEAGMast_cells_activated5.9149e-030.2252image
ENSG00000178252.16,WDR6PAADEAGPlasma_cells3.4418e-020.3396image
chr3:49008926-49011498:+PRADEERDendritic_cells_activated5.9359e-050.4908image
ENSG00000178252.16,WDR6PRADEAGDendritic_cells_activated5.9359e-050.4908image
chr3:49008926-49011498:+SARCEERMacrophages_M14.9212e-020.3018image
ENSG00000178252.16,WDR6SARCEAGMacrophages_M02.6643e-02-0.3341image
chr3:49008926-49011498:+STADEERMacrophages_M04.4390e-02-0.1553image
ENSG00000178252.16,WDR6STADEAGMacrophages_M04.6106e-02-0.1541image
chr3:49008926-49011498:+THCAEERPlasma_cells5.6316e-030.2121image
ENSG00000178252.16,WDR6THCAEAGPlasma_cells4.6510e-030.2161image


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6. Enriched editing regions and immune gene sets for WDR6


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000178252.16,WDR6BLCAGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.2376e-03-0.3521image
chr3:49008926-49011498:+BLCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER3.2376e-03-0.3521image
chr3:49008926-49011498:+BRCAGSVA_HALLMARK_G2M_CHECKPOINTEER2.4313e-03-0.1593image
ENSG00000178252.16,WDR6BRCAGSVA_HALLMARK_G2M_CHECKPOINTEAG3.0250e-03-0.1556image
chr3:49008926-49011498:+CESCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER4.6876e-04-0.5052image
ENSG00000178252.16,WDR6CESCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG1.5301e-03-0.4587image
chr3:49008926-49011498:+COADGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.8476e-020.2955image
ENSG00000178252.16,WDR6COADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.8476e-020.2955image
ENSG00000178252.16,WDR6ESCAGSVA_HALLMARK_APICAL_JUNCTIONEAG1.7092e-020.2842image
chr3:49008926-49011498:+ESCAGSVA_HALLMARK_APICAL_JUNCTIONEER1.7170e-020.2841image
chr3:49008926-49011498:+GBMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.2587e-02-0.2825image
ENSG00000178252.16,WDR6GBMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.2587e-02-0.2825image
chr3:49008926-49011498:+LGGGSVA_HALLMARK_DNA_REPAIREER4.2926e-03-0.1705image
ENSG00000178252.16,WDR6LGGGSVA_HALLMARK_DNA_REPAIREAG4.2926e-03-0.1705image
ENSG00000178252.16,WDR6LIHCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG2.5685e-03-0.6227image
chr3:49008926-49011498:+LUSCGSVA_HALLMARK_MYC_TARGETS_V2EER7.4856e-030.3127image
ENSG00000178252.16,WDR6LUSCGSVA_HALLMARK_MYC_TARGETS_V2EAG7.4856e-030.3127image
ENSG00000178252.16,WDR6MESOGSVA_HALLMARK_PEROXISOMEEAG1.0067e-02-0.5252image
chr3:49008926-49011498:+MESOGSVA_HALLMARK_PEROXISOMEEER1.0067e-02-0.5252image
ENSG00000178252.16,WDR6OVGSVA_HALLMARK_MYC_TARGETS_V2EAG2.1412e-020.1890image
chr3:49008926-49011498:+OVGSVA_HALLMARK_MYC_TARGETS_V2EER1.9968e-020.1918image
ENSG00000178252.16,WDR6PRADGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.0179e-03-0.3736image
chr3:49008926-49011498:+PRADGSVA_HALLMARK_MITOTIC_SPINDLEEER3.0179e-03-0.3736image
ENSG00000178252.16,WDR6SARCGSVA_HALLMARK_MTORC1_SIGNALINGEAG3.4253e-03-0.4318image
chr3:49008926-49011498:+SARCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER8.3030e-03-0.3975image
ENSG00000178252.16,WDR6SKCMGSVA_HALLMARK_SPERMATOGENESISEAG1.3970e-02-0.2791image
chr3:49008926-49011498:+SKCMGSVA_HALLMARK_SPERMATOGENESISEER1.3970e-02-0.2791image
chr3:49008926-49011498:+STADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER2.2603e-02-0.1758image
ENSG00000178252.16,WDR6STADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG2.1596e-02-0.1772image


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7. Enriched editing regions and drugs for WDR6


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr3:49008926-49011498:+BLCAKIN001.135EER2.3492e-020.2745image
ENSG00000178252.16,WDR6BLCAKIN001.135EAG2.3492e-020.2745image
chr3:49008926-49011498:+BRCABryostatin.1EER2.7641e-02-0.1161image
ENSG00000178252.16,WDR6BRCABryostatin.1EAG2.6561e-02-0.1167image
chr3:49008926-49011498:+CESCAxitinibEER9.2639e-04-0.4819image
ENSG00000178252.16,WDR6CESCAxitinibEAG5.0840e-04-0.4974image
ENSG00000178252.16,WDR6COADBicalutamideEAG1.4283e-03-0.4196image
chr3:49008926-49011498:+COADBicalutamideEER1.4283e-03-0.4196image
chr3:49008926-49011498:+ESCAAZD8055EER3.0922e-02-0.2582image
ENSG00000178252.16,WDR6ESCAAZD8055EAG3.0255e-02-0.2592image
chr3:49008926-49011498:+GBMCGP.082996EER2.4030e-020.2797image
ENSG00000178252.16,WDR6GBMCGP.082996EAG2.4030e-020.2797image
chr3:49008926-49011498:+KIRCMetforminEER2.3391e-040.4728image
ENSG00000178252.16,WDR6KIRCMetforminEAG2.3391e-040.4728image
ENSG00000178252.16,WDR6KIRPFTI.277EAG1.6362e-02-0.3485image
chr3:49008926-49011498:+KIRPFTI.277EER1.6362e-02-0.3485image
ENSG00000178252.16,WDR6LAMLBX.795EAG3.4239e-020.1896image
chr3:49008926-49011498:+LAMLBX.795EER3.4239e-020.1896image
ENSG00000178252.16,WDR6LGGCisplatinEAG3.8405e-040.2111image
chr3:49008926-49011498:+LGGCisplatinEER3.8405e-040.2111image
ENSG00000178252.16,WDR6LIHCCEP.701EAG3.3254e-03-0.6100image
ENSG00000178252.16,WDR6LUADElesclomolEAG5.7225e-03-0.1972image
chr3:49008926-49011498:+LUADElesclomolEER5.7839e-03-0.1970image
ENSG00000178252.16,WDR6LUSCGW843682XEAG1.3316e-02-0.2905image
chr3:49008926-49011498:+LUSCGW843682XEER1.3316e-02-0.2905image
ENSG00000178252.16,WDR6MESOBosutinibEAG1.6649e-02-0.4937image
chr3:49008926-49011498:+MESOBosutinibEER1.6649e-02-0.4937image
ENSG00000178252.16,WDR6PAADAKT.inhibitor.VIIIEAG3.2025e-03-0.4602image
ENSG00000178252.16,WDR6PRADDocetaxelEAG1.0758e-020.3244image
chr3:49008926-49011498:+PRADDocetaxelEER1.0758e-020.3244image
chr3:49008926-49011498:+SARCLenalidomideEER9.1862e-03-0.3927image
ENSG00000178252.16,WDR6SARCLenalidomideEAG1.3189e-02-0.3709image
chr3:49008926-49011498:+SKCMAZD6244EER2.7056e-02-0.2520image
ENSG00000178252.16,WDR6SKCMAZD6244EAG2.7056e-02-0.2520image
chr3:49008926-49011498:+STADJNJ.26854165EER7.0688e-030.2071image
ENSG00000178252.16,WDR6STADJNJ.26854165EAG6.1754e-030.2105image
ENSG00000178252.16,WDR6THCACCT018159EAG2.2609e-03-0.2327image
chr3:49008926-49011498:+THCACCT018159EER3.8894e-03-0.2210image
ENSG00000178252.16,WDR6UCECABT.888EAG1.5163e-020.5346image
chr3:49008926-49011498:+UCECABT.888EER1.5163e-020.5346image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType