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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: KAT7 (ImmuneEditome ID:11143)

1. Gene summary of enriched editing regions for KAT7

check button Gene summary
Gene informationGene symbol

KAT7

Gene ID

11143

GeneSynonymsHBO1|HBOA|MYST2|ZC2HC7
GeneCytomap

17q21.33

GeneTypeprotein-coding
GeneDescriptionhistone acetyltransferase KAT7|K(lysine) acetyltransferase 7|MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2|MYST histone acetyltransferase 2|histone acetyltransferase MYST2|histone acetyltransferase binding to ORC1
GeneModificationdate20230518
UniprotIDO95251;A0A6Q8PHH2;E7EUP3
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr17:49830360-49832257:+ENST00000259021.7ENSG00000136504.10KAT7UTR3AluSz6,AluSz,MIRc,(TTTTATT)n,MIRb,AluSx1,AluYchr17:49830360-49832257:+.alignment


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2. Tumor-specific enriched editing regions for KAT7


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr17:49830360-49832257:+BRCAPathEER4.4782e-023.0164e-020.1146image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000136504.10,KAT7GBMEAG3.8977e-021.2133e-025.4759e+01image

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3. Enriched editing regions and immune related genes for KAT7


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr17:49830360-49832257:+TGCTEERENSG00000136451,VEZF10.39723.7201e-046.9658e-070.4236imageNELAVL1;FUS;HNRNPLVEZF1Macrophages_M2GSVA_HALLMARK_UV_RESPONSE_DN
chr17:49830360-49832257:+TGCTEERENSG00000106246,PTCD1-0.39204.4680e-042.9456e-06-0.4012imageNELAVL1;FUS;HNRNPLNAMacrophages_M2GSVA_HALLMARK_UV_RESPONSE_DN
chr17:49830360-49832257:+TGCTEERENSG00000167693,NXN0.36827.0759e-041.7288e-070.4438imageNELAVL1;FUS;HNRNPLNXNMacrophages_M2GSVA_HALLMARK_ANGIOGENESIS
chr17:49830360-49832257:+TGCTEERENSG00000186174,BCL9L0.38247.5704e-041.7238e-070.4439imageNELAVL1;FUSBCL9LMacrophages_M2GSVA_HALLMARK_TGF_BETA_SIGNALING
chr17:49830360-49832257:+TGCTEERENSG00000085382,HACE10.37051.2418e-031.4802e-090.5044imageNELAVL1;FUS;HNRNPLHACE1Macrophages_M2GSVA_HALLMARK_HEDGEHOG_SIGNALING
chr17:49830360-49832257:+TGCTEERENSG00000151743,AMN10.36571.5520e-031.1387e-060.4162imageNELAVL1;FUS;HNRNPLNAMacrophages_M2GSVA_HALLMARK_HEDGEHOG_SIGNALING
chr17:49830360-49832257:+TGCTEERENSG00000175183,CSRP20.34361.6548e-031.3615e-070.4472imageNELAVL1;FUS;HNRNPLNAMacrophages_M2GSVA_HALLMARK_ANGIOGENESIS
chr17:49830360-49832257:+TGCTEERENSG00000152104,PTPN140.36251.7318e-031.0717e-060.4171imageNELAVL1;FUS;HNRNPLNAMacrophages_M2GSVA_HALLMARK_HEDGEHOG_SIGNALING
chr17:49830360-49832257:+TGCTEERENSG00000033867,SLC4A70.35051.7980e-033.8366e-090.4932imageNELAVL1;FUS;HNRNPLNAMacrophages_M2GSVA_HALLMARK_TGF_BETA_SIGNALING
chr17:49830360-49832257:+TGCTEERENSG00000112186,CAP20.34102.7147e-032.8784e-060.4016imageNELAVL1;FUS;HNRNPLNAMacrophages_M2GSVA_HALLMARK_UV_RESPONSE_DN

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4. Enriched editing regions and immune related splicing for KAT7


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr17:49830360-49832257:+
TGCTEERA5ENSG00000085999.7chr146248511:46248598:46247731:46247746:46247731:46248408-0.28922.9151e-021.6331e-06-0.4298imageNELAVL1;FUS;HNRNPLNAMacrophages_M2GSVA_HALLMARK_ANGIOGENESIS
chr17:49830360-49832257:+
TGCTEERIRENSG00000198742.5chr799047683:99047882:99049562:99049709-0.39122.9722e-033.8842e-06-0.4058imageNELAVL1;FUS;HNRNPLSMURF1Macrophages_M2GSVA_HALLMARK_TGF_BETA_SIGNALING
chr17:49830360-49832257:+
TGCTEERIRENSG00000197119.8chr14100293293:100293377:100295625:1002956560.42081.3414e-033.3399e-060.4006imageNELAVL1;FUS;HNRNPLNAMacrophages_M2GSVA_HALLMARK_UV_RESPONSE_DN
chr17:49830360-49832257:+
TGCTEERA5ENSG00000140451.8chr1564821166:64821281:64822265:64822337:64821366:648223370.29774.3699e-025.4194e-060.4017imageNELAVL1;HNRNPLNAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr17:49830360-49832257:+
TGCTEERESENSG00000167107.8chr1750464247:50464294:50464525:50464599:50471027:50471065-0.37753.3722e-031.5922e-07-0.4466imageNELAVL1;FUS;HNRNPLACSF2Macrophages_M2GSVA_HALLMARK_NOTCH_SIGNALING
chr17:49830360-49832257:+
TGCTEERA5ENSG00000106246.13chr799429587:99429806:99433277:99433418:99432923:994334180.42368.0184e-041.8702e-060.4099imageNELAVL1;FUS;HNRNPLNAMacrophages_M2GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr17:49830360-49832257:+
TGCTEERMEXENSG00000148444.11chr1022318104:22318168:22318271:22318306:22318352:22318862:22318958:223190180.35781.4734e-022.3857e-060.4046imageNELAVL1;FUSNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
chr17:49830360-49832257:+
TGCTEERIRENSG00000004777.14chr1935785408:35785483:35786412:35786598-0.35316.6663e-031.8495e-06-0.4296imageNELAVL1;FUS;HNRNPLNAMast_cells_restingGSVA_HALLMARK_NOTCH_SIGNALING
chr17:49830360-49832257:+
TGCTEERESENSG00000197119.8chr14100293293:100293377:100295625:100295993:100298841:100298885-0.40091.7476e-032.4163e-07-0.4423imageNELAVL1;FUS;HNRNPLNAMacrophages_M2GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr17:49830360-49832257:+
TGCTEERA5ENSG00000185215.4chr14103126309:103126575:103123460:103123483:103123460:1031239510.32081.0228e-026.6179e-070.4732imageNELAVL1;FUS;HNRNPLTNFAIP2T_cells_regulatory_(Tregs)GSVA_HALLMARK_HEDGEHOG_SIGNALING

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5. Enriched editing regions and immune infiltration for KAT7


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000136504.10,KAT7BLCAEAGT_cells_CD88.4947e-040.4068image
ENSG00000136504.10,KAT7BRCAEAGMacrophages_M01.9755e-020.1225image
ENSG00000136504.10,KAT7CESCEAGMacrophages_M22.1573e-020.3986image
chr17:49830360-49832257:+ESCAEERNeutrophils1.3111e-020.2713image
ENSG00000136504.10,KAT7ESCAEAGNeutrophils2.7198e-020.2368image
ENSG00000136504.10,KAT7GBMEAGB_cells_naive4.9124e-020.3172image
ENSG00000136504.10,KAT7LAMLEAGMacrophages_M24.5604e-030.4244image
ENSG00000136504.10,KAT7LGGEAGMast_cells_activated3.0049e-020.2007image
chr17:49830360-49832257:+LUADEERMacrophages_M07.9634e-050.3610image
ENSG00000136504.10,KAT7LUADEAGMacrophages_M01.2853e-040.3496image
chr17:49830360-49832257:+LUSCEERB_cells_naive3.6330e-020.2883image
ENSG00000136504.10,KAT7LUSCEAGT_cells_CD89.2002e-03-0.3451image
chr17:49830360-49832257:+OVEERT_cells_follicular_helper3.6206e-02-0.2645image
ENSG00000136504.10,KAT7OVEAGT_cells_follicular_helper4.2406e-02-0.2469image
chr17:49830360-49832257:+PCPGEERMacrophages_M18.8395e-030.3562image
ENSG00000136504.10,KAT7PCPGEAGEosinophils1.3875e-020.3271image
chr17:49830360-49832257:+SARCEERT_cells_CD83.3313e-030.3890image
ENSG00000136504.10,KAT7SARCEAGT_cells_CD89.6258e-030.3373image
chr17:49830360-49832257:+SKCMEEREosinophils2.3420e-020.2160image
ENSG00000136504.10,KAT7SKCMEAGEosinophils2.5726e-020.2098image
chr17:49830360-49832257:+STADEERMast_cells_activated2.6666e-02-0.1798image
ENSG00000136504.10,KAT7STADEAGMast_cells_resting1.4427e-020.1956image
chr17:49830360-49832257:+TGCTEERMacrophages_M21.3597e-040.3322image
ENSG00000136504.10,KAT7TGCTEAGDendritic_cells_activated4.6549e-02-0.1756image
ENSG00000136504.10,KAT7THYMEAGMacrophages_M01.3960e-020.5160image


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6. Enriched editing regions and immune gene sets for KAT7


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000136504.10,KAT7LUADEAG1.0099e-020.23901.3274e-020.23032.3961e-020.21053.4101e-020.1978image
chr17:49830360-49832257:+LUADEER1.7741e-020.22172.9935e-020.20343.9035e-020.19361.8754e-020.2199image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000136504.10,KAT7BLCAGSVA_HALLMARK_ADIPOGENESISEAG4.0715e-02-0.2566image
chr17:49830360-49832257:+BRCAGSVA_HALLMARK_HEME_METABOLISMEER2.2074e-030.1617image
ENSG00000136504.10,KAT7BRCAGSVA_HALLMARK_HEME_METABOLISMEAG8.3408e-040.1749image
ENSG00000136504.10,KAT7CESCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.3421e-020.4261image
chr17:49830360-49832257:+ESCAGSVA_HALLMARK_IL2_STAT5_SIGNALINGEER3.4004e-020.2330image
ENSG00000136504.10,KAT7GBMGSVA_HALLMARK_MYOGENESISEAG1.3572e-040.5734image
ENSG00000136504.10,KAT7KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.7617e-030.3751image
ENSG00000136504.10,KAT7LGGGSVA_HALLMARK_MYC_TARGETS_V2EAG1.3192e-02-0.2286image
ENSG00000136504.10,KAT7LUADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG2.7413e-030.2769image
chr17:49830360-49832257:+LUADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER2.3084e-030.2827image
chr17:49830360-49832257:+LUSCGSVA_HALLMARK_P53_PATHWAYEER3.8267e-020.2855image
ENSG00000136504.10,KAT7LUSCGSVA_HALLMARK_P53_PATHWAYEAG3.1719e-020.2874image
ENSG00000136504.10,KAT7PCPGGSVA_HALLMARK_HEME_METABOLISMEAG1.4142e-020.3262image
chr17:49830360-49832257:+PCPGGSVA_HALLMARK_HEME_METABOLISMEER4.1172e-030.3878image
chr17:49830360-49832257:+SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.0886e-020.3109image
ENSG00000136504.10,KAT7SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.5919e-020.3153image
chr17:49830360-49832257:+STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.2990e-020.1644image
chr17:49830360-49832257:+TGCTGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER2.0201e-050.3685image
ENSG00000136504.10,KAT7TGCTGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG4.9310e-02-0.1735image
ENSG00000136504.10,KAT7THCAGSVA_HALLMARK_GLYCOLYSISEAG1.3550e-020.1598image
ENSG00000136504.10,KAT7THYMGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG1.4282e-020.5145image


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7. Enriched editing regions and drugs for KAT7


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000136504.10,KAT7BLCALapatinibEAG5.0953e-030.3461image
chr17:49830360-49832257:+BRCAATRAEER6.8269e-030.1433image
ENSG00000136504.10,KAT7BRCAATRAEAG1.2713e-020.1310image
ENSG00000136504.10,KAT7CESCAKT.inhibitor.VIIIEAG3.1278e-03-0.4988image
chr17:49830360-49832257:+ESCABexaroteneEER4.1195e-02-0.2246image
ENSG00000136504.10,KAT7GBMBI.D1870EAG6.5281e-040.5220image
ENSG00000136504.10,KAT7KIRCLFM.A13EAG2.1567e-030.3019image
ENSG00000136504.10,KAT7KIRPBryostatin.1EAG2.6448e-020.2712image
ENSG00000136504.10,KAT7LGGCytarabineEAG7.4895e-050.3578image
ENSG00000136504.10,KAT7LUADAS601245EAG1.2966e-030.2964image
chr17:49830360-49832257:+LUADAS601245EER5.8083e-030.2568image
chr17:49830360-49832257:+LUSCFH535EER3.2455e-02-0.2943image
ENSG00000136504.10,KAT7LUSCCCT018159EAG1.7758e-02-0.3158image
chr17:49830360-49832257:+OVBMS.754807EER5.3593e-03-0.3468image
ENSG00000136504.10,KAT7OVBMS.754807EAG2.6708e-03-0.3587image
ENSG00000136504.10,KAT7PCPGCamptothecinEAG1.0852e-020.3379image
chr17:49830360-49832257:+PCPGCamptothecinEER3.7254e-030.3917image
ENSG00000136504.10,KAT7PRADLapatinibEAG1.5122e-020.2853image
chr17:49830360-49832257:+SARCABT.263EER6.4740e-05-0.5119image
ENSG00000136504.10,KAT7SARCABT.263EAG1.2595e-04-0.4823image
ENSG00000136504.10,KAT7SKCMMG.132EAG2.9312e-020.2060image
chr17:49830360-49832257:+SKCMMG.132EER1.6649e-020.2289image
chr17:49830360-49832257:+TGCTCI.1040EER7.4168e-060.3860image
ENSG00000136504.10,KAT7TGCTAG.014699EAG9.2177e-03-0.2284image
ENSG00000136504.10,KAT7THCAABT.263EAG2.5790e-020.1445image
ENSG00000136504.10,KAT7THYMLenalidomideEAG2.9012e-030.6042image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType