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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: RPP14 (ImmuneEditome ID:11102)

1. Gene summary of enriched editing regions for RPP14

check button Gene summary
Gene informationGene symbol

RPP14

Gene ID

11102

GeneSynonymsP14
GeneCytomap

3p14.3

GeneTypeprotein-coding
GeneDescriptionribonuclease P protein subunit p14|ribonuclease P/MRP 14kDa subunit
GeneModificationdate20230518
UniprotIDO95059;L0R6P0
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr3:58318380-58319024:+ENST00000462046.1ENSG00000163684.10RPP14ncRNA_exonicAluSz,AluSx1chr3:58318380-58319024:+.alignment
chr3:58320384-58323350:+ENST00000445193.6ENSG00000163684.10RPP14UTR3AluY,MIRb,L1MB7,AluJo,AluSz,LTR49,AluSq2chr3:58320384-58323350:+.alignment


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2. Tumor-specific enriched editing regions for RPP14


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr3:58320384-58323350:+BRCAEER3.5534e-02image
ENSG00000163684.10,RPP14BRCAEAG3.2548e-03image
chr3:58320384-58323350:+KICHEER9.3662e-03image
ENSG00000163684.10,RPP14KICHEAG4.4825e-03image
ENSG00000163684.10,RPP14KIRCEAG4.2795e-02image
chr3:58320384-58323350:+KIRPEER5.6522e-03image
ENSG00000163684.10,RPP14KIRPEAG6.7563e-03image
chr3:58320384-58323350:+PRADEER3.3263e-02image
ENSG00000163684.10,RPP14PRADEAG3.9775e-02image
chr3:58320384-58323350:+UCECEER1.2025e-03image
ENSG00000163684.10,RPP14UCECEAG3.2995e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr3:58320384-58323350:+ESCAEER1.4052e-024.4157e-033.9926e-03image
ENSG00000163684.10,RPP14ESCAEAG1.9096e-021.0066e-031.4508e-03image
ENSG00000163684.10,RPP14READEAG1.5722e-022.5803e-024.3808e+03image

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3. Enriched editing regions and immune related genes for RPP14


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr3:58320384-58323350:+PRADEERENSG00000037749,MFAP30.43054.7202e-176.5508e-190.4037imageNCELF2;DHX9;EIF4A3;ELAVL1;ELAVL3;FBL;HNRNPC;HNRNPM;IGF2BP1;IGF2BP2;MBNL2;NOP56;NOP58;RANGAP1;RBFOX2;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;U2AF2NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr3:58320384-58323350:+KICHEERENSG00000039650,PNKP-0.61012.5449e-023.0809e-06-0.5654imageNAIFM1;CELF2;EIF4A3;EIF4G2;ELAVL1;FBL;HNRNPC;HNRNPM;IGF2BP1;IGF2BP2;NOP56;NOP58;RANGAP1;RBFOX2;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;U2AF2;VIMNANK_cells_restingGSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:58320384-58323350:+KICHEERENSG00000113790,EHHADH0.58013.0289e-021.4093e-030.4063imageNDHX9;EIF4A3;ELAVL1;FBL;HNRNPC;HNRNPM;IGF2BP1;IGF2BP2;NOP56;NOP58;RBFOX2;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;U2AF2NAMonocytesGSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:58320384-58323350:+KICHEERENSG00000268713,CTC-444N24.8-0.58303.2648e-022.2362e-05-0.5220imageNELAVL1;FBL;HNRNPC;HNRNPM;IGF2BP1;IGF2BP2;NOP56;NOP58;RBFOX2;SRSF1;TAF15;TARDBP;U2AF2NANK_cells_restingGSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:58320384-58323350:+KICHEERENSG00000077312,SNRPA-0.57313.7689e-021.0163e-03-0.4170imageNAIFM1;CELF2;DHX9;EIF4A3;EIF4G2;ELAVL1;FBL;HNRNPC;HNRNPM;IGF2BP1;IGF2BP2;NOP56;NOP58;RANGAP1;RBFOX2;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;U2AF2;VIMNAT_cells_CD4_memory_activatedGSVA_HALLMARK_BILE_ACID_METABOLISM
chr3:58320384-58323350:+KICHEERENSG00000128973,CLN6-0.55773.9176e-021.0422e-06-0.5867imageNAIFM1;CELF2;DHX9;EIF4A3;EIF4G2;ELAVL1;FBL;HNRNPC;HNRNPM;IGF2BP1;IGF2BP2;MBNL2;NOP56;NOP58;RANGAP1;RBFOX2;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;U2AF2;VIMNANK_cells_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr3:58320384-58323350:+KICHEERENSG00000169570,DTWD20.55844.2150e-022.0392e-060.5737imageNCELF2;DHX9;EIF4A3;ELAVL1;ELAVL3;FBL;HNRNPC;HNRNPM;IGF2BP1;IGF2BP2;MBNL2;NOP56;NOP58;RBFOX2;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;U2AF2NADendritic_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr3:58320384-58323350:+KICHEERENSG00000130204,TOMM40-0.55974.2498e-023.2191e-06-0.5644imageNAIFM1;CELF2;DHX9;EIF4A3;EIF4G2;ELAVL1;FBL;HNRNPC;HNRNPM;IGF2BP1;IGF2BP2;NOP56;NOP58;RANGAP1;RBFOX2;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;U2AF2;VIMNAGSVA_HALLMARK_HEME_METABOLISM
chr3:58320384-58323350:+KICHEERENSG00000132549,VPS13B0.55004.2812e-021.3483e-050.5336imageNAIFM1;CELF2;DHX9;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FBL;HNRNPC;HNRNPM;IGF2BP1;IGF2BP2;MBNL2;NOP56;NOP58;RANGAP1;RBFOX2;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;U2AF2;VIMNANeutrophilsGSVA_HALLMARK_MITOTIC_SPINDLE
chr3:58320384-58323350:+KICHEERENSG00000273437,RP11-434H6.7-0.55844.4098e-026.9955e-05-0.4940imageNELAVL1;HNRNPC;NOP58;U2AF2NAMacrophages_M0GSVA_HALLMARK_ANDROGEN_RESPONSE

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4. Enriched editing regions and immune related splicing for RPP14


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr3:58320384-58323350:+
COADEERMEXENSG00000118816.5chr477048134:77048662:77055149:77055203:77058506:77058635:77066248:77066405-0.42273.8307e-073.6190e-11-0.4152imageNAIFM1;CELF2;DHX9;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FBL;HNRNPC;HNRNPM;IGF2BP1;IGF2BP2;NOP56;NOP58;RANGAP1;RBFOX2;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;U2AF2;VIMNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_DN
chr3:58320384-58323350:+
ESCAEERESENSG00000217128.7chr5131709200:131709272:131710577:131710661:131716564:131716656-0.37194.2321e-031.0749e-08-0.4661imageNAIFM1;CELF2;DHX9;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FBL;HNRNPC;HNRNPM;IGF2BP1;IGF2BP2;MBNL2;NOP56;NOP58;RANGAP1;RBFOX2;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;U2AF2;VIMNANK_cells_restingGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr3:58320384-58323350:+
ESCAEERESENSG00000180530.5chr2114967995:14968526:15014343:15014466:15043494:15043570-0.39072.8019e-036.7818e-07-0.4053imageNAIFM1;CELF2;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FBL;HNRNPC;HNRNPM;IGF2BP1;IGF2BP2;MBNL2;NOP56;NOP58;RANGAP1;RBFOX2;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;U2AF2NRIP1T_cells_regulatory_(Tregs)GSVA_HALLMARK_HEME_METABOLISM
chr3:58320384-58323350:+
KICHEERMEXENSG00000115170.9chr2157738439:157738570:157760879:157761077:157770367:157770514:157774087:157774187-0.66292.7829e-021.4515e-05-0.5360imageNCELF2;DHX9;EIF4A3;EIF4G2;ELAVL1;FBL;HNRNPC;HNRNPM;IGF2BP1;IGF2BP2;MBNL2;NOP56;NOP58;RANGAP1;RBFOX2;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;U2AF2ACVR1T_cells_CD4_memory_activatedGSVA_HALLMARK_HEME_METABOLISM
chr3:58320384-58323350:+
KICHEERIRENSG00000122257.14chr1624548944:24553557:24555614:24555703-0.60504.2591e-023.8235e-05-0.5130imageNAIFM1;CELF2;DHX9;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FBL;HNRNPC;HNRNPM;IGF2BP1;IGF2BP2;MBNL2;NOP56;NOP58;RANGAP1;RBFOX2;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;U2AF2;VIMNAT_cells_CD4_memory_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000163684.10,RPP14
KICHEAGMEXENSG00000115170.9chr2157738439:157738570:157760879:157761077:157770367:157770514:157774087:157774187-0.68333.7901e-021.0839e-05-0.5426imageNACIN1;ADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS2;LIN28;LIN28B;MOV10;MSI1;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;RBM5;RC3H1;SF3A3;SF3B4;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1;ZNF184ACVR1T_cells_CD4_memory_activatedGSVA_HALLMARK_HEME_METABOLISM
ENSG00000163684.10,RPP14
TGCTEAGMEXENSG00000198690.5chr1530903892:30904011:30904511:30904543:30905724:30905897:30908117:309082580.30678.3654e-032.3881e-060.4379imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZNF184FAN1GSVA_HALLMARK_DNA_REPAIR
ENSG00000163684.10,RPP14
TGCTEAGMEXENSG00000169919.12chr765974525:65974704:65974918:65976202:65979833:65979911:65980223:65980409-0.38301.6717e-031.1429e-06-0.4087imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28B;LSM11;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184GUSBT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
chr3:58320384-58323350:+
TGCTEERA5ENSG00000198728.6chr10102107582:102108323:102109034:102109174:102109028:1021091740.29344.4563e-022.9256e-070.4257imageNAIFM1;CELF2;EIF4A3;EIF4G2;ELAVL1;FBL;HNRNPC;HNRNPM;IGF2BP1;IGF2BP2;NOP56;NOP58;RANGAP1;RBFOX2;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;U2AF2;VIMNAB_cells_naiveGSVA_HALLMARK_TGF_BETA_SIGNALING
chr3:58320384-58323350:+
TGCTEERIRENSG00000176890.11chr18667720:669173:670691:6708670.30173.0907e-022.2748e-110.5352imageNAIFM1;CELF2;DHX9;EIF4A3;EIF4G2;ELAVL1;FBL;HNRNPC;HNRNPM;IGF2BP1;IGF2BP2;NOP56;NOP58;RANGAP1;RBFOX2;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;U2AF2;VIMNAMacrophages_M2GSVA_HALLMARK_TGF_BETA_SIGNALING

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5. Enriched editing regions and immune infiltration for RPP14


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr3:58320384-58323350:+ACCEERMast_cells_activated2.3553e-020.2806image
chr3:58320384-58323350:+BLCAEERT_cells_regulatory_(Tregs)1.5997e-03-0.1888image
ENSG00000163684.10,RPP14BLCAEAGT_cells_regulatory_(Tregs)7.8110e-03-0.1559image
chr3:58320384-58323350:+BRCAEERT_cells_follicular_helper2.6336e-02-0.0725image
chr3:58320384-58323350:+CESCEERNK_cells_resting1.6881e-020.1525image
ENSG00000163684.10,RPP14CHOLEAGNK_cells_activated2.9128e-040.6438image
chr3:58320384-58323350:+COADEERMacrophages_M21.6554e-030.2046image
ENSG00000163684.10,RPP14COADEAGNeutrophils1.7385e-030.2024image
chr3:58320384-58323350:+DLBCEERT_cells_follicular_helper1.7113e-03-0.5401image
ENSG00000163684.10,RPP14DLBCEAGT_cells_follicular_helper2.6200e-03-0.5067image
chr3:58318380-58319024:+ESCAEERPlasma_cells1.6777e-030.2862image
chr3:58320384-58323350:+ESCAEERT_cells_CD4_naive1.7480e-030.2518image
ENSG00000163684.10,RPP14ESCAEAGB_cells_naive3.4381e-030.2307image
chr3:58320384-58323350:+GBMEERT_cells_CD4_memory_activated7.9316e-030.2182image
ENSG00000163684.10,RPP14GBMEAGT_cells_CD4_memory_activated2.4710e-030.2462image
chr3:58318380-58319024:+HNSCEERMacrophages_M03.6999e-020.1965image
chr3:58320384-58323350:+HNSCEERT_cells_CD82.5933e-02-0.1237image
chr3:58320384-58323350:+KICHEERDendritic_cells_resting1.1786e-030.4122image
ENSG00000163684.10,RPP14KICHEAGDendritic_cells_resting9.8536e-030.3335image
chr3:58318380-58319024:+KIRCEERT_cells_regulatory_(Tregs)2.5712e-020.2364image
chr3:58320384-58323350:+KIRCEERNeutrophils1.8907e-030.1820image
ENSG00000163684.10,RPP14KIRCEAGMast_cells_resting2.3451e-030.1733image
chr3:58320384-58323350:+KIRPEERT_cells_CD4_memory_activated5.1349e-080.3511image
ENSG00000163684.10,RPP14KIRPEAGT_cells_CD4_memory_activated2.4337e-050.2716image
chr3:58320384-58323350:+LGGEERMast_cells_resting2.7266e-020.0977image
chr3:58320384-58323350:+LIHCEERB_cells_memory5.1403e-03-0.1593image
ENSG00000163684.10,RPP14LIHCEAGB_cells_memory1.6423e-02-0.1353image
chr3:58320384-58323350:+LUADEERT_cells_CD4_memory_activated4.2228e-030.1800image
ENSG00000163684.10,RPP14LUADEAGT_cells_CD4_memory_activated2.2743e-020.1356image
chr3:58320384-58323350:+LUSCEERT_cells_CD4_memory_resting3.9557e-020.1185image
chr3:58320384-58323350:+MESOEERT_cells_CD81.1737e-030.3967image
ENSG00000163684.10,RPP14MESOEAGT_cells_CD82.7444e-020.2715image
chr3:58318380-58319024:+OVEERB_cells_naive2.1286e-02-0.2011image
chr3:58320384-58323350:+OVEERT_cells_CD86.9632e-030.1648image
ENSG00000163684.10,RPP14OVEAGNK_cells_activated4.6394e-020.1200image
chr3:58320384-58323350:+PAADEERMacrophages_M12.5030e-020.2045image
chr3:58320384-58323350:+PCPGEERB_cells_memory1.5357e-020.1856image
ENSG00000163684.10,RPP14PCPGEAGB_cells_memory4.8071e-030.2147image
chr3:58320384-58323350:+PRADEERT_cells_CD4_memory_resting5.5322e-040.1629image
ENSG00000163684.10,RPP14PRADEAGB_cells_naive2.0819e-030.1441image
chr3:58320384-58323350:+READEERNK_cells_activated1.2461e-02-0.2669image
ENSG00000163684.10,RPP14READEAGNK_cells_activated2.4454e-02-0.2411image
chr3:58320384-58323350:+SARCEERB_cells_memory4.5487e-02-0.1303image
ENSG00000163684.10,RPP14SARCEAGB_cells_naive3.2052e-02-0.1387image
chr3:58318380-58319024:+STADEERB_cells_naive4.0071e-02-0.1302image
chr3:58320384-58323350:+STADEERT_cells_CD4_memory_resting1.9029e-02-0.1372image
chr3:58320384-58323350:+THCAEERDendritic_cells_activated6.2828e-030.1235image
ENSG00000163684.10,RPP14THCAEAGNeutrophils9.5201e-030.1172image
chr3:58320384-58323350:+THYMEERMacrophages_M25.3772e-050.3704image
ENSG00000163684.10,RPP14THYMEAGMacrophages_M24.9960e-050.3704image
chr3:58320384-58323350:+UCSEERDendritic_cells_resting3.8004e-030.3909image
ENSG00000163684.10,RPP14UCSEAGEosinophils5.7431e-040.4496image
ENSG00000163684.10,RPP14UVMEAGB_cells_memory3.6675e-020.3966image


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6. Enriched editing regions and immune gene sets for RPP14


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr3:58320384-58323350:+BLCAGSVA_HALLMARK_MITOTIC_SPINDLEEER1.7659e-040.2235image
ENSG00000163684.10,RPP14BLCAGSVA_HALLMARK_UV_RESPONSE_UPEAG1.0037e-030.1922image
chr3:58320384-58323350:+BRCAGSVA_HALLMARK_PROTEIN_SECRETIONEER1.1947e-140.2481image
ENSG00000163684.10,RPP14BRCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.0775e-060.1518image
chr3:58320384-58323350:+CESCGSVA_HALLMARK_UV_RESPONSE_DNEER6.3465e-040.2168image
ENSG00000163684.10,RPP14CESCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.8683e-040.2328image
ENSG00000163684.10,RPP14CHOLGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG3.3581e-02-0.4102image
chr3:58320384-58323350:+COADGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER4.0917e-070.3239image
ENSG00000163684.10,RPP14COADGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG7.3824e-060.2866image
chr3:58320384-58323350:+DLBCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER5.0379e-030.4910image
ENSG00000163684.10,RPP14DLBCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.6452e-030.5265image
ENSG00000163684.10,RPP14ESCAGSVA_HALLMARK_GLYCOLYSISEAG3.5620e-02-0.1668image
chr3:58320384-58323350:+ESCAGSVA_HALLMARK_PEROXISOMEEER4.1601e-04-0.2828image
chr3:58318380-58319024:+ESCAGSVA_HALLMARK_MYOGENESISEER2.1493e-020.2115image
ENSG00000163684.10,RPP14GBMGSVA_HALLMARK_ANDROGEN_RESPONSEEAG2.2844e-030.2481image
chr3:58320384-58323350:+GBMGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER4.2303e-040.2871image
chr3:58318380-58319024:+HNSCGSVA_HALLMARK_MITOTIC_SPINDLEEER2.9222e-03-0.2775image
ENSG00000163684.10,RPP14HNSCGSVA_HALLMARK_PEROXISOMEEAG1.1834e-04-0.2052image
chr3:58320384-58323350:+HNSCGSVA_HALLMARK_DNA_REPAIREER7.6133e-05-0.2180image
chr3:58320384-58323350:+KICHGSVA_HALLMARK_MITOTIC_SPINDLEEER2.6883e-040.4576image
ENSG00000163684.10,RPP14KICHGSVA_HALLMARK_MITOTIC_SPINDLEEAG6.3207e-040.4321image
chr3:58318380-58319024:+KIRCGSVA_HALLMARK_ANGIOGENESISEER2.6044e-02-0.2359image
ENSG00000163684.10,RPP14KIRCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG1.6935e-020.1364image
chr3:58320384-58323350:+KIRCGSVA_HALLMARK_ANDROGEN_RESPONSEEER5.9816e-050.2338image
chr3:58320384-58323350:+KIRPGSVA_HALLMARK_ANDROGEN_RESPONSEEER2.4077e-040.2409image
ENSG00000163684.10,RPP14KIRPGSVA_HALLMARK_ANDROGEN_RESPONSEEAG4.1140e-030.1865image
ENSG00000163684.10,RPP14LAMLGSVA_HALLMARK_DNA_REPAIREAG1.8794e-02-0.3490image
chr3:58320384-58323350:+LGGGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER7.4510e-07-0.2169image
ENSG00000163684.10,RPP14LGGGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG6.7070e-06-0.1971image
ENSG00000163684.10,RPP14LIHCGSVA_HALLMARK_SPERMATOGENESISEAG3.4189e-03-0.1647image
chr3:58320384-58323350:+LIHCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.2634e-030.1832image
ENSG00000163684.10,RPP14LUADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG7.9875e-030.1577image
chr3:58320384-58323350:+LUADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER1.2492e-040.2398image
chr3:58320384-58323350:+LUSCGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.0601e-020.1469image
chr3:58320384-58323350:+MESOGSVA_HALLMARK_APICAL_JUNCTIONEER4.0076e-030.3549image
ENSG00000163684.10,RPP14MESOGSVA_HALLMARK_APICAL_JUNCTIONEAG1.6860e-020.2933image
ENSG00000163684.10,RPP14OVGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG4.0845e-030.1723image
chr3:58318380-58319024:+OVGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.5047e-020.2120image
chr3:58320384-58323350:+OVGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER1.6919e-040.2282image
ENSG00000163684.10,RPP14PAADGSVA_HALLMARK_UV_RESPONSE_DNEAG1.6266e-020.2129image
chr3:58320384-58323350:+PAADGSVA_HALLMARK_TGF_BETA_SIGNALINGEER5.4889e-040.3109image
chr3:58320384-58323350:+PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEER7.0937e-050.2999image
ENSG00000163684.10,RPP14PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEAG6.7716e-040.2574image
chr3:58320384-58323350:+PRADGSVA_HALLMARK_UV_RESPONSE_DNEER7.2888e-140.3444image
ENSG00000163684.10,RPP14PRADGSVA_HALLMARK_UV_RESPONSE_DNEAG1.3519e-110.3104image
chr3:58320384-58323350:+READGSVA_HALLMARK_MITOTIC_SPINDLEEER5.0731e-030.2979image
ENSG00000163684.10,RPP14READGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.0505e-020.2730image
chr3:58320384-58323350:+SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.9243e-030.1825image
ENSG00000163684.10,RPP14SARCGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.5155e-030.1831image
chr3:58320384-58323350:+SKCMGSVA_HALLMARK_PROTEIN_SECRETIONEER2.7984e-050.2232image
ENSG00000163684.10,RPP14SKCMGSVA_HALLMARK_PROTEIN_SECRETIONEAG6.7792e-060.2350image
ENSG00000163684.10,RPP14STADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG3.4299e-020.1166image
chr3:58320384-58323350:+STADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER3.9387e-060.2663image
chr3:58318380-58319024:+STADGSVA_HALLMARK_MITOTIC_SPINDLEEER2.6166e-04-0.2294image
ENSG00000163684.10,RPP14TGCTGSVA_HALLMARK_HEME_METABOLISMEAG2.8335e-05-0.3520image
chr3:58320384-58323350:+TGCTGSVA_HALLMARK_HEME_METABOLISMEER6.7793e-05-0.3360image
ENSG00000163684.10,RPP14THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG2.2223e-100.2818image
chr3:58320384-58323350:+THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER4.1447e-120.3070image
chr3:58320384-58323350:+THYMGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER3.5217e-080.4904image
ENSG00000163684.10,RPP14THYMGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG4.7445e-070.4511image
chr3:58320384-58323350:+UCECGSVA_HALLMARK_DNA_REPAIREER5.9863e-06-0.3546image
ENSG00000163684.10,RPP14UCECGSVA_HALLMARK_DNA_REPAIREAG2.0994e-06-0.3692image
chr3:58320384-58323350:+UCSGSVA_HALLMARK_ANDROGEN_RESPONSEEER3.4234e-020.2914image


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7. Enriched editing regions and drugs for RPP14


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000163684.10,RPP14ACCGDC0941EAG2.0218e-02-0.2853image
chr3:58320384-58323350:+BLCAJNK.Inhibitor.VIIIEER2.9198e-05-0.2483image
ENSG00000163684.10,RPP14BLCAKIN001.135EAG7.7823e-05-0.2299image
chr3:58320384-58323350:+BRCAGW843682XEER1.1677e-080.1847image
ENSG00000163684.10,RPP14BRCAAZD6482EAG2.3842e-05-0.1355image
chr3:58320384-58323350:+CESCKIN001.135EER1.0589e-03-0.2084image
ENSG00000163684.10,RPP14CESCFTI.277EAG3.6066e-04-0.2226image
ENSG00000163684.10,RPP14CHOLEpothilone.BEAG2.3366e-02-0.4350image
chr3:58320384-58323350:+COADCCT007093EER1.3194e-03-0.2088image
ENSG00000163684.10,RPP14COADGW.441756EAG1.7261e-030.2025image
ENSG00000163684.10,RPP14DLBCEmbelinEAG1.7802e-02-0.4100image
chr3:58320384-58323350:+DLBCErlotinibEER4.7713e-020.3584image
ENSG00000163684.10,RPP14ESCALenalidomideEAG8.9480e-04-0.2609image
chr3:58320384-58323350:+ESCAAMG.706EER9.3764e-05-0.3125image
chr3:58318380-58319024:+ESCAABT.263EER3.7040e-020.1930image
ENSG00000163684.10,RPP14GBMMetforminEAG2.8431e-020.1796image
chr3:58320384-58323350:+GBMMG.132EER7.7049e-030.2190image
chr3:58318380-58319024:+HNSCBAY.61.3606EER1.1101e-040.3556image
ENSG00000163684.10,RPP14HNSCKIN001.135EAG7.9355e-04-0.1793image
chr3:58320384-58323350:+HNSCKIN001.135EER5.5100e-06-0.2494image
chr3:58320384-58323350:+KICHBMS.536924EER2.3059e-070.6141image
ENSG00000163684.10,RPP14KICHBMS.536924EAG1.6010e-060.5784image
chr3:58318380-58319024:+KIRCEmbelinEER5.6379e-030.2912image
ENSG00000163684.10,RPP14KIRCAZD.2281EAG4.7360e-030.1613image
chr3:58320384-58323350:+KIRCBMS.536924EER1.4371e-040.2222image
chr3:58320384-58323350:+KIRPGW843682XEER1.1248e-030.2144image
ENSG00000163684.10,RPP14KIRPBMS.754807EAG4.3669e-030.1853image
ENSG00000163684.10,RPP14LAMLMidostaurinEAG2.1307e-020.3424image
chr3:58320384-58323350:+LGGAZD6482EER1.4983e-08-0.2472image
ENSG00000163684.10,RPP14LGGAZD6482EAG5.0581e-07-0.2194image
chr3:58320384-58323350:+LIHCIPA.3EER1.7456e-040.2126image
ENSG00000163684.10,RPP14LIHCIPA.3EAG6.7873e-040.1908image
ENSG00000163684.10,RPP14LUADDoxorubicinEAG1.4956e-03-0.1882image
chr3:58320384-58323350:+LUADDoxorubicinEER4.2846e-02-0.1279image
chr3:58320384-58323350:+LUSCMetforminEER5.1185e-040.1988image
ENSG00000163684.10,RPP14LUSCAUY922EAG2.6122e-020.1217image
chr3:58320384-58323350:+MESOGefitinibEER1.8713e-03-0.3814image
ENSG00000163684.10,RPP14MESOGefitinibEAG1.2898e-03-0.3879image
ENSG00000163684.10,RPP14OVAG.014699EAG7.6580e-030.1602image
chr3:58318380-58319024:+OVBAY.61.3606EER5.2566e-030.2425image
chr3:58320384-58323350:+OVDasatinibEER1.7055e-03-0.1915image
ENSG00000163684.10,RPP14PAADIPA.3EAG2.0308e-02-0.2143image
chr3:58320384-58323350:+PAADDMOGEER9.9160e-03-0.2375image
chr3:58320384-58323350:+PCPGAZD.0530EER8.1351e-030.2030image
ENSG00000163684.10,RPP14PCPGKU.55933EAG1.1001e-020.1940image
chr3:58320384-58323350:+PRADBMS.536924EER9.9312e-120.3160image
ENSG00000163684.10,RPP14PRADBMS.536924EAG3.6129e-100.2897image
chr3:58320384-58323350:+READBMS.536924EER1.4708e-040.3981image
ENSG00000163684.10,RPP14READBMS.536924EAG6.3543e-040.3611image
chr3:58320384-58323350:+SARCJNK.Inhibitor.VIIIEER8.5980e-06-0.2851image
ENSG00000163684.10,RPP14SARCJNK.Inhibitor.VIIIEAG7.1825e-06-0.2857image
chr3:58320384-58323350:+SKCMBMS.536924EER1.5367e-030.1702image
ENSG00000163684.10,RPP14SKCMCEP.701EAG5.9921e-040.1803image
ENSG00000163684.10,RPP14STADCI.1040EAG1.1195e-02-0.1395image
chr3:58318380-58319024:+STADBAY.61.3606EER1.5727e-030.1993image
chr3:58320384-58323350:+STADBortezomibEER7.3966e-06-0.2589image
ENSG00000163684.10,RPP14TGCTBX.795EAG1.2840e-020.2137image
chr3:58320384-58323350:+TGCTBX.795EER2.0963e-020.1986image
ENSG00000163684.10,RPP14THCACEP.701EAG6.0893e-140.3310image
chr3:58320384-58323350:+THCACEP.701EER7.7380e-160.3542image
chr3:58320384-58323350:+THYMGSK269962AEER1.4490e-090.5310image
ENSG00000163684.10,RPP14THYMDocetaxelEAG3.7714e-080.4875image
chr3:58320384-58323350:+UCECFH535EER8.3741e-050.3106image
ENSG00000163684.10,RPP14UCECFH535EAG2.0188e-040.2934image
ENSG00000163684.10,RPP14UCSAZD.2281EAG4.3656e-020.2731image
chr3:58320384-58323350:+UCSBMS.754807EER4.3008e-030.3861image
ENSG00000163684.10,RPP14UVMBI.D1870EAG5.5790e-030.5098image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType