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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: HPSE (ImmuneEditome ID:10855)

1. Gene summary of enriched editing regions for HPSE

check button Gene summary
Gene informationGene symbol

HPSE

Gene ID

10855

GeneSynonymsHPA|HPA1|HPR1|HPSE1|HSE1
GeneCytomap

4q21.23

GeneTypeprotein-coding
GeneDescriptionheparanase|endo-glucoronidase|heparanase-1
GeneModificationdate20230329
UniprotIDQ9Y251;D6RHG4;A0A7P0TBD9;D6RAQ1
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr4:83294055-83295098:-ENST00000311412.8ENSG00000173083.13HPSEUTR3AluSz,AluJo,AluSx1chr4:83294055-83295098:-.alignment
chr4:83294055-83295098:-ENST00000405413.5ENSG00000173083.13HPSEUTR3AluSz,AluJo,AluSx1chr4:83294055-83295098:-.alignment


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2. Tumor-specific enriched editing regions for HPSE


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr4:83294055-83295098:-COADEER1.1016e-03image
ENSG00000173083.13,HPSECOADEAG5.4422e-04image
chr4:83294055-83295098:-HNSCEER3.6249e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr4:83294055-83295098:-SKCMPathEER9.1460e-032.2931e-020.2933image
ENSG00000173083.13,HPSESKCMPathEAG4.8821e-036.0299e-030.3423image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr4:83294055-83295098:-ESCAEER9.0009e-035.3574e-044.5229e+02image
ENSG00000173083.13,HPSEESCAEAG2.8836e-025.3408e-031.3399e+02image

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3. Enriched editing regions and immune related genes for HPSE


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr4:83294055-83295098:-ESCAEERENSG00000153561,RMND5A-0.45965.0720e-045.5449e-06-0.4029imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZNF184NAMacrophages_M1GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr4:83294055-83295098:-ESCAEERENSG00000166106,ADAMTS150.37907.5158e-034.2416e-090.5063imageNCNBP;CSTF2T;DGCR8;DKC1;EIF4A3;ELAVL1;FBL;FMR1;FUS;HNRNPC;IGF2BP2;LIN28;NOP56;NOP58;PTBP1;RBFOX2;SRSF1;TAF15;TARDBP;U2AF2;UPF1NAPlasma_cellsGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr4:83294055-83295098:-ESCAEERENSG00000173083,HPSE-0.37049.4674e-031.6751e-06-0.4227imageNADAR;CNBP;CSTF2T;DGCR8;DKC1;EIF4A3;ELAVL1;EWSR1;FBL;FUS;HNRNPA1;HNRNPC;IGF2BP2;IGF2BP3;LIN28;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM47;SRSF1;SRSF3;TAF15;TIA1;U2AF2;UPF1NAGSVA_HALLMARK_P53_PATHWAY
chr4:83294055-83295098:-ESCAEERENSG00000083444,PLOD10.35011.6703e-025.8059e-060.4021imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZNF184NAMacrophages_M0GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr4:83294055-83295098:-ESCAEERENSG00000183963,SMTN0.34381.8456e-026.0539e-060.4014imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZNF184NAMast_cells_restingGSVA_HALLMARK_MYOGENESIS
chr4:83294055-83295098:-ESCAEERENSG00000115414,FN10.32193.1344e-021.4757e-060.4248imageNADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LARP7;LIN28;LIN28B;MOV10;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;RBM5;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZNF184FN1Macrophages_M2GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr4:83294055-83295098:-ESCAEERENSG00000153561,RMND5A-0.45965.0720e-045.5449e-06-0.4029imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZNF184NAMacrophages_M1GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr4:83294055-83295098:-ESCAEERENSG00000166106,ADAMTS150.37907.5158e-034.2416e-090.5063imageNCNBP;CSTF2T;DGCR8;DKC1;EIF4A3;ELAVL1;FBL;FMR1;FUS;HNRNPC;IGF2BP2;LIN28;NOP56;NOP58;PTBP1;RBFOX2;SRSF1;TAF15;TARDBP;U2AF2;UPF1NAPlasma_cellsGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr4:83294055-83295098:-ESCAEERENSG00000173083,HPSE-0.37049.4674e-031.6751e-06-0.4227imageNADAR;CNBP;CSTF2T;DGCR8;DKC1;EIF4A3;ELAVL1;EWSR1;FBL;FUS;HNRNPA1;HNRNPC;IGF2BP2;IGF2BP3;LIN28;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM47;SRSF1;SRSF3;TAF15;TIA1;U2AF2;UPF1NAGSVA_HALLMARK_P53_PATHWAY
chr4:83294055-83295098:-ESCAEERENSG00000083444,PLOD10.35011.6703e-025.8059e-060.4021imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZNF184NAMacrophages_M0GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr4:83294055-83295098:-ESCAEERENSG00000183963,SMTN0.34381.8456e-026.0539e-060.4014imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZNF184NAMast_cells_restingGSVA_HALLMARK_MYOGENESIS
chr4:83294055-83295098:-ESCAEERENSG00000115414,FN10.32193.1344e-021.4757e-060.4248imageNADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LARP7;LIN28;LIN28B;MOV10;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;RBM5;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZNF184FN1Macrophages_M2GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION

More results



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4. Enriched editing regions and immune related splicing for HPSE


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr4:83294055-83295098:-
ESCAEERMEXENSG00000129657.10chr1777215971:77215984:77216010:77216088:77216101:77216127:77216257:772162700.29074.3438e-027.1377e-050.4083imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZNF184NAT_cells_CD4_naiveGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr4:83294055-83295098:-
ESCAEERMEXENSG00000129657.10chr1777215971:77215984:77216010:77216062:77216101:77216387:77216426:772168020.27034.5655e-021.4870e-050.4461imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZNF184NAT_cells_CD4_naiveGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr4:83294055-83295098:-
ESCAEERMEXENSG00000129657.10chr1777215971:77215984:77216010:77216075:77216101:77216387:77216426:772168020.27034.5655e-021.4870e-050.4461imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZNF184NAT_cells_CD4_naiveGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr4:83294055-83295098:-
ESCAEERMEXENSG00000129657.10chr1777215971:77215984:77216010:77216101:77216101:77216387:77216426:772168020.27034.5655e-021.4870e-050.4461imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZNF184NAT_cells_CD4_naiveGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr4:83294055-83295098:-
ESCAEERMEXENSG00000129657.10chr1777215971:77215984:77216010:77216088:77216101:77216387:77216426:772168020.27554.0677e-021.2908e-050.4490imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZNF184NAT_cells_CD4_naiveGSVA_HALLMARK_XENOBIOTIC_METABOLISM

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5. Enriched editing regions and immune infiltration for HPSE


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr4:83294055-83295098:-BLCAEERT_cells_CD4_memory_activated4.4585e-020.3116image
ENSG00000173083.13,HPSEBLCAEAGT_cells_CD4_memory_activated3.2622e-020.3122image
chr4:83294055-83295098:-BRCAEERMacrophages_M04.4423e-02-0.1612image
ENSG00000173083.13,HPSEBRCAEAGMacrophages_M03.7740e-02-0.1609image
chr4:83294055-83295098:-COADEERT_cells_CD4_memory_activated2.8570e-02-0.3162image
ENSG00000173083.13,HPSECOADEAGT_cells_CD4_memory_activated2.0820e-02-0.3294image
chr4:83294055-83295098:-ESCAEERMacrophages_M21.6479e-020.2195image
ENSG00000173083.13,HPSEESCAEAGMacrophages_M29.3887e-030.2362image
chr4:83294055-83295098:-GBMEERMonocytes2.6987e-02-0.2607image
ENSG00000173083.13,HPSEGBMEAGT_cells_regulatory_(Tregs)2.7393e-020.2600image
chr4:83294055-83295098:-HNSCEERNK_cells_resting6.9416e-030.1652image
ENSG00000173083.13,HPSEHNSCEAGMacrophages_M04.4013e-020.1229image
chr4:83294055-83295098:-KICHEERNK_cells_activated2.9280e-020.4451image
ENSG00000173083.13,HPSEKICHEAGNK_cells_activated2.9280e-020.4451image
chr4:83294055-83295098:-KIRCEERMonocytes3.2429e-020.1790image
ENSG00000173083.13,HPSEKIRCEAGMonocytes7.1807e-030.2224image
chr4:83294055-83295098:-KIRPEERT_cells_CD4_memory_activated2.8898e-070.8019image
ENSG00000173083.13,HPSEKIRPEAGT_cells_CD4_memory_activated2.8898e-070.8019image
chr4:83294055-83295098:-LAMLEERMast_cells_activated3.8244e-020.4009image
ENSG00000173083.13,HPSELAMLEAGMast_cells_activated3.8244e-020.4009image
chr4:83294055-83295098:-LGGEERT_cells_regulatory_(Tregs)1.0779e-02-0.2359image
ENSG00000173083.13,HPSELGGEAGT_cells_regulatory_(Tregs)1.1069e-02-0.2341image
ENSG00000173083.13,HPSELUSCEAGT_cells_CD4_naive1.7517e-02-0.1674image
ENSG00000173083.13,HPSEMESOEAGMonocytes3.7217e-020.3641image
chr4:83294055-83295098:-OVEERMacrophages_M04.3367e-030.2324image
ENSG00000173083.13,HPSEOVEAGMacrophages_M01.0657e-030.2572image
chr4:83294055-83295098:-PAADEERMacrophages_M12.5655e-020.4211image
ENSG00000173083.13,HPSEPAADEAGMacrophages_M12.9178e-020.4053image
chr4:83294055-83295098:-SKCMEERPlasma_cells4.5769e-020.2362image
ENSG00000173083.13,HPSESTADEAGEosinophils6.0532e-05-0.2875image
chr4:83294055-83295098:-THYMEERMacrophages_M01.7830e-020.4892image


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6. Enriched editing regions and immune gene sets for HPSE


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr4:83294055-83295098:-BLCAGSVA_HALLMARK_KRAS_SIGNALING_UPEER6.6419e-030.4124image
ENSG00000173083.13,HPSEBLCAGSVA_HALLMARK_UV_RESPONSE_DNEAG6.9296e-030.3887image
chr4:83294055-83295098:-BRCAGSVA_HALLMARK_NOTCH_SIGNALINGEER3.1448e-02-0.1723image
chr4:83294055-83295098:-CESCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER2.5844e-020.1767image
ENSG00000173083.13,HPSECESCGSVA_HALLMARK_IL2_STAT5_SIGNALINGEAG3.7971e-020.1627image
ENSG00000173083.13,HPSEESCAGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.5124e-03-0.2865image
chr4:83294055-83295098:-ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER2.0201e-03-0.2803image
ENSG00000173083.13,HPSEGBMGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG2.1506e-020.2706image
chr4:83294055-83295098:-GBMGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER2.8547e-020.2582image
chr4:83294055-83295098:-HNSCGSVA_HALLMARK_PANCREAS_BETA_CELLSEER5.5558e-040.2103image
ENSG00000173083.13,HPSEHNSCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG2.2354e-040.2232image
ENSG00000173083.13,HPSEKIRPGSVA_HALLMARK_HEME_METABOLISMEAG4.7041e-03-0.5185image
chr4:83294055-83295098:-KIRPGSVA_HALLMARK_HEME_METABOLISMEER4.7041e-03-0.5185image
ENSG00000173083.13,HPSELGGGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.9096e-020.2164image
chr4:83294055-83295098:-LGGGSVA_HALLMARK_KRAS_SIGNALING_DNEER2.2930e-020.2111image
ENSG00000173083.13,HPSELUADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.4802e-030.2364image
chr4:83294055-83295098:-LUADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER6.2411e-040.2808image
ENSG00000173083.13,HPSELUSCGSVA_HALLMARK_APOPTOSISEAG1.0123e-020.1810image
chr4:83294055-83295098:-LUSCGSVA_HALLMARK_MITOTIC_SPINDLEEER5.1198e-030.1997image
chr4:83294055-83295098:-MESOGSVA_HALLMARK_MTORC1_SIGNALINGEER1.2336e-02-0.4440image
ENSG00000173083.13,HPSEMESOGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.3076e-02-0.4275image
chr4:83294055-83295098:-OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.6515e-02-0.1634image
ENSG00000173083.13,HPSEOVGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.1439e-020.2001image
chr4:83294055-83295098:-PAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.3566e-030.5350image
ENSG00000173083.13,HPSEPAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.4845e-030.5246image
chr4:83294055-83295098:-SARCGSVA_HALLMARK_UV_RESPONSE_DNEER2.5133e-020.2414image
ENSG00000173083.13,HPSESARCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.2473e-02-0.2365image
ENSG00000173083.13,HPSESKCMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG3.5453e-020.2433image
chr4:83294055-83295098:-STADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER4.6313e-020.1471image
ENSG00000173083.13,HPSESTADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG2.0916e-020.1679image
chr4:83294055-83295098:-THYMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.4826e-030.6234image
ENSG00000173083.13,HPSETHYMGSVA_HALLMARK_DNA_REPAIREAG1.0820e-02-0.5006image


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7. Enriched editing regions and drugs for HPSE


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr4:83294055-83295098:-BLCAAZD.2281EER2.1128e-02-0.3548image
ENSG00000173083.13,HPSEBLCAAZD.2281EAG2.2013e-02-0.3334image
ENSG00000173083.13,HPSEBRCACGP.082996EAG4.9238e-020.1524image
chr4:83294055-83295098:-BRCADMOGEER2.5112e-020.1793image
chr4:83294055-83295098:-CESCJW.7.52.1EER3.3742e-02-0.1685image
ENSG00000173083.13,HPSECOADLFM.A13EAG2.8063e-020.3139image
chr4:83294055-83295098:-COADLFM.A13EER3.3645e-020.3073image
ENSG00000173083.13,HPSEESCAGSK269962AEAG1.6674e-05-0.3820image
chr4:83294055-83295098:-ESCAGSK269962AEER1.7515e-06-0.4220image
ENSG00000173083.13,HPSEGBMMethotrexateEAG3.0540e-020.2551image
chr4:83294055-83295098:-GBMMethotrexateEER3.3571e-020.2508image
ENSG00000173083.13,HPSEHNSCAKT.inhibitor.VIIIEAG5.8246e-030.1677image
chr4:83294055-83295098:-HNSCAKT.inhibitor.VIIIEER1.0201e-030.2003image
chr4:83294055-83295098:-KIRCAKT.inhibitor.VIIIEER1.7623e-030.2602image
ENSG00000173083.13,HPSEKIRCAKT.inhibitor.VIIIEAG1.2753e-030.2659image
ENSG00000173083.13,HPSEKIRPAS601245EAG1.6743e-030.5665image
chr4:83294055-83295098:-KIRPAS601245EER1.6743e-030.5665image
ENSG00000173083.13,HPSELGGATRAEAG1.2828e-020.2294image
chr4:83294055-83295098:-LGGATRAEER1.4271e-020.2270image
ENSG00000173083.13,HPSELUADCGP.60474EAG7.9755e-03-0.2152image
chr4:83294055-83295098:-LUADCGP.60474EER4.8994e-03-0.2325image
chr4:83294055-83295098:-LUSCAMG.706EER3.3480e-02-0.1524image
chr4:83294055-83295098:-MESOCCT007093EER6.4493e-03-0.4787image
ENSG00000173083.13,HPSEMESOCCT007093EAG1.0683e-03-0.5439image
chr4:83294055-83295098:-OVMetforminEER3.9654e-020.1688image
ENSG00000173083.13,HPSEOVEmbelinEAG3.4233e-03-0.2308image
chr4:83294055-83295098:-PAADA.443654EER2.1832e-02-0.4316image
ENSG00000173083.13,HPSEPAADGemcitabineEAG3.9404e-02-0.3846image
ENSG00000173083.13,HPSESARCLFM.A13EAG1.3853e-02-0.2544image
chr4:83294055-83295098:-SARCLFM.A13EER1.1350e-02-0.2718image
ENSG00000173083.13,HPSESKCMDocetaxelEAG6.8279e-03-0.3098image
chr4:83294055-83295098:-SKCMDocetaxelEER3.9605e-02-0.2431image
chr4:83294055-83295098:-STADBMS.708163EER1.5886e-020.1776image
ENSG00000173083.13,HPSESTADBMS.708163EAG3.5918e-030.2108image
ENSG00000173083.13,HPSETHCAAZ628EAG2.2402e-020.2186image
chr4:83294055-83295098:-THCAMethotrexateEER3.1437e-02-0.2132image
ENSG00000173083.13,HPSETHYMGSK.650394EAG1.6972e-030.5952image
chr4:83294055-83295098:-THYMBMS.536924EER2.0322e-05-0.7661image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType