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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: GIPC1 (ImmuneEditome ID:10755)

1. Gene summary of enriched editing regions for GIPC1

check button Gene summary
Gene informationGene symbol

GIPC1

Gene ID

10755

GeneSynonymsC19orf3|GIPC|GLUT1CBP|Hs.6454|IIP-1|NIP|OPDM2|RGS19IP1|SEMCAP|SYNECTIIN|SYNECTIN|TIP-2
GeneCytomap

19p13.12

GeneTypeprotein-coding
GeneDescriptionPDZ domain-containing protein GIPC1|GAIP C-terminus-interacting protein|GLUT1 C-terminal binding protein|IGF-1 receptor interacting protein 1|RGS-GAIP-interacting protein|RGS19-interacting protein 1|regulator of G-protein signalling 19 interacting protein 1|tax interaction protein 2
GeneModificationdate20230517
UniprotIDA0A024R7I0;O14908;A0A024R7I1;K7ELJ2;K7ESN1;K7EJ33;K7EIT0;K7EM11
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr19:14480982-14481626:-ENST00000345425.5ENSG00000123159.14GIPC1intronicL2b,AluJb,AluSc,FLAM_Achr19:14480982-14481626:-.alignment
chr19:14480982-14481626:-ENST00000393028.4ENSG00000123159.14GIPC1intronicL2b,AluJb,AluSc,FLAM_Achr19:14480982-14481626:-.alignment
chr19:14480982-14481626:-ENST00000393033.7ENSG00000123159.14GIPC1intronicL2b,AluJb,AluSc,FLAM_Achr19:14480982-14481626:-.alignment
chr19:14480982-14481626:-ENST00000586027.4ENSG00000123159.14GIPC1intronicL2b,AluJb,AluSc,FLAM_Achr19:14480982-14481626:-.alignment
chr19:14480982-14481626:-ENST00000587210.1ENSG00000123159.14GIPC1intronicL2b,AluJb,AluSc,FLAM_Achr19:14480982-14481626:-.alignment
chr19:14480982-14481626:-ENST00000589497.4ENSG00000123159.14GIPC1intronicL2b,AluJb,AluSc,FLAM_Achr19:14480982-14481626:-.alignment
chr19:14480982-14481626:-ENST00000591349.4ENSG00000123159.14GIPC1intronicL2b,AluJb,AluSc,FLAM_Achr19:14480982-14481626:-.alignment
chr19:14483177-14491511:-ENST00000587811.1ENSG00000123159.14GIPC1ncRNA_exonic(TTCT)n,AluY,AluSp,MER91A,(AG)n,AluSx1,MLT1I,MIRc,MSTB2,L2a,(AAT)n,AluSz,Zaphod2,AluSg,AluSq2,AluSz6,AluSx3,AluJo,AluSx,AluJrchr19:14483177-14491511:-.alignment


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2. Tumor-specific enriched editing regions for GIPC1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000123159.14,GIPC1BRCAEAG2.3553e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr19:14483177-14491511:-KIRPCliEER1.9088e-021.2367e-020.4184image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for GIPC1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:14483177-14491511:-OVEERENSG00000213867,RP11-829H16.20.20061.8774e-025.5104e-150.4533imageNNNAT_cells_CD8GSVA_HALLMARK_MITOTIC_SPINDLE

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4. Enriched editing regions and immune related splicing for GIPC1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:14483177-14491511:-
OVEERIRENSG00000143457.6chr1150694107:150694173:150694655:150694850-0.31247.9796e-066.7120e-11-0.4235imageNNNAMacrophages_M0GSVA_HALLMARK_GLYCOLYSIS
ENSG00000123159.14,GIPC1
PCPGEAGESENSG00000140750.12chr1624935469:24935639:24939363:24939597:24941986:24942143-0.37061.8527e-032.6217e-07-0.4019imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZNF184ARHGAP17T_cells_CD4_memory_activatedGSVA_HALLMARK_HYPOXIA
ENSG00000123159.14,GIPC1
PCPGEAGA5ENSG00000160752.10chr1155310042:155310205:155308915:155308965:155308915:1553099650.37051.9329e-032.9322e-070.4016imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZNF184NAT_cells_CD4_memory_activatedGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
ENSG00000123159.14,GIPC1
PCPGEAGIRENSG00000258315.1chr177016494:7016525:7016909:7017014-0.43361.1807e-047.1407e-08-0.4163imageNAUH;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DICER1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPK;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RNF219;RTCB;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr19:14483177-14491511:-
STADEERIRENSG00000124104.14chr2045840321:45840458:45840638:45840780-0.30111.9936e-071.1172e-11-0.4169imageNNNAMacrophages_M2GSVA_HALLMARK_UV_RESPONSE_UP
chr19:14483177-14491511:-
STADEERIRENSG00000116350.11chr129165889:29166912:29168502:29168638-0.29418.9600e-078.9901e-13-0.4226imageNNNAB_cells_memoryGSVA_HALLMARK_HEME_METABOLISM
ENSG00000123159.14,GIPC1
STADEAGIRENSG00000116350.11chr129165889:29166912:29168502:29168638-0.27945.2769e-065.3247e-12-0.4092imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NCBP3;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZNF184NAB_cells_memoryGSVA_HALLMARK_HEME_METABOLISM

More results



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5. Enriched editing regions and immune infiltration for GIPC1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000123159.14,GIPC1ACCEAGPlasma_cells3.4544e-040.6812image
chr19:14483177-14491511:-BLCAEERT_cells_CD4_memory_activated1.3845e-020.2130image
ENSG00000123159.14,GIPC1BLCAEAGNeutrophils6.6756e-030.2199image
chr19:14480982-14481626:-BRCAEERMast_cells_activated2.0024e-020.2534image
chr19:14483177-14491511:-BRCAEERMacrophages_M24.7723e-030.1201image
ENSG00000123159.14,GIPC1BRCAEAGT_cells_regulatory_(Tregs)2.1374e-02-0.0859image
ENSG00000123159.14,GIPC1CESCEAGMast_cells_resting4.6176e-020.1871image
ENSG00000123159.14,GIPC1CHOLEAGMonocytes1.4904e-020.5118image
chr19:14480982-14481626:-ESCAEERPlasma_cells4.3606e-020.2321image
chr19:14483177-14491511:-ESCAEERMacrophages_M11.2261e-030.2534image
ENSG00000123159.14,GIPC1ESCAEAGMacrophages_M12.0133e-030.2424image
chr19:14480982-14481626:-GBMEERDendritic_cells_resting1.3935e-020.4949image
chr19:14483177-14491511:-GBMEERMonocytes4.1939e-030.3112image
ENSG00000123159.14,GIPC1GBMEAGEosinophils2.9923e-02-0.2100image
ENSG00000123159.14,GIPC1HNSCEAGMast_cells_activated3.0838e-020.2915image
chr19:14483177-14491511:-KIRCEERMacrophages_M13.2964e-030.4431image
ENSG00000123159.14,GIPC1KIRCEAGMacrophages_M04.5676e-020.2124image
chr19:14483177-14491511:-KIRPEERT_cells_CD4_memory_activated7.3188e-070.6454image
ENSG00000123159.14,GIPC1KIRPEAGT_cells_CD4_memory_activated1.6228e-060.5661image
chr19:14483177-14491511:-LGGEERMacrophages_M01.0968e-020.1871image
ENSG00000123159.14,GIPC1LGGEAGMacrophages_M06.2360e-050.1918image
ENSG00000123159.14,GIPC1LIHCEAGB_cells_memory7.8503e-030.2832image
chr19:14483177-14491511:-LUADEERT_cells_regulatory_(Tregs)2.0851e-020.1601image
chr19:14483177-14491511:-LUSCEERT_cells_gamma_delta4.9480e-030.2092image
ENSG00000123159.14,GIPC1LUSCEAGT_cells_gamma_delta9.6431e-030.1804image
chr19:14480982-14481626:-OVEERB_cells_memory2.8113e-020.2553image
chr19:14483177-14491511:-OVEERT_cells_CD81.7600e-030.1902image
ENSG00000123159.14,GIPC1OVEAGT_cells_CD82.2009e-030.1852image
ENSG00000123159.14,GIPC1PCPGEAGMonocytes8.1451e-030.2118image
ENSG00000123159.14,GIPC1PRADEAGPlasma_cells3.9542e-030.3759image
ENSG00000123159.14,GIPC1SARCEAGNK_cells_activated1.8626e-030.3936image
chr19:14483177-14491511:-SKCMEERDendritic_cells_resting3.9939e-020.1582image
ENSG00000123159.14,GIPC1SKCMEAGMacrophages_M11.2709e-020.1689image
chr19:14480982-14481626:-STADEERT_cells_CD4_memory_activated2.4535e-030.4004image
chr19:14483177-14491511:-STADEERT_cells_CD4_memory_activated1.5463e-020.1357image
ENSG00000123159.14,GIPC1STADEAGT_cells_CD4_memory_activated1.0145e-020.1435image
ENSG00000123159.14,GIPC1TGCTEAGT_cells_CD4_memory_activated5.1029e-03-0.4761image
ENSG00000123159.14,GIPC1THCAEAGB_cells_naive3.7864e-02-0.1726image
ENSG00000123159.14,GIPC1THYMEAGT_cells_CD88.6743e-03-0.4310image
chr19:14483177-14491511:-UCECEERNeutrophils4.2721e-070.6118image
ENSG00000123159.14,GIPC1UCECEAGNeutrophils5.3276e-080.5922image


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6. Enriched editing regions and immune gene sets for GIPC1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr19:14483177-14491511:-STADEER3.4384e-040.19957.0177e-030.15094.5718e-040.19549.4355e-060.2456image
ENSG00000123159.14,GIPC1STADEAG4.5275e-040.19497.2171e-030.14995.7431e-040.19153.5436e-050.2290image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000123159.14,GIPC1ACCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG3.0083e-02-0.4527image
chr19:14483177-14491511:-BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER3.1768e-030.2540image
chr19:14483177-14491511:-BRCAGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.9818e-060.2010image
chr19:14480982-14481626:-BRCAGSVA_HALLMARK_UV_RESPONSE_DNEER2.4724e-020.2450image
ENSG00000123159.14,GIPC1BRCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG3.5505e-05-0.1538image
chr19:14483177-14491511:-CESCGSVA_HALLMARK_HEME_METABOLISMEER7.0453e-030.2640image
ENSG00000123159.14,GIPC1CESCGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.9117e-040.3213image
chr19:14483177-14491511:-CHOLGSVA_HALLMARK_MYOGENESISEER4.3171e-02-0.4451image
chr19:14483177-14491511:-ESCAGSVA_HALLMARK_DNA_REPAIREER2.1062e-040.2890image
ENSG00000123159.14,GIPC1ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG2.7120e-040.2842image
chr19:14480982-14481626:-ESCAGSVA_HALLMARK_GLYCOLYSISEER4.1409e-030.3253image
ENSG00000123159.14,GIPC1GBMGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.4585e-05-0.4057image
chr19:14483177-14491511:-GBMGSVA_HALLMARK_APOPTOSISEER4.6450e-050.4315image
ENSG00000123159.14,GIPC1HNSCGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.8689e-020.3162image
ENSG00000123159.14,GIPC1KIRCGSVA_HALLMARK_HYPOXIAEAG7.9652e-04-0.3492image
ENSG00000123159.14,GIPC1KIRPGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG9.4290e-03-0.3272image
ENSG00000123159.14,GIPC1LGGGSVA_HALLMARK_BILE_ACID_METABOLISMEAG9.4465e-04-0.1589image
ENSG00000123159.14,GIPC1LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG6.0268e-04-0.3605image
ENSG00000123159.14,GIPC1LUADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG3.1000e-03-0.1856image
chr19:14483177-14491511:-LUADGSVA_HALLMARK_APOPTOSISEER1.1960e-030.2232image
ENSG00000123159.14,GIPC1LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG8.2408e-03-0.1841image
chr19:14483177-14491511:-LUSCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER1.4917e-020.1817image
chr19:14483177-14491511:-OVGSVA_HALLMARK_FATTY_ACID_METABOLISMEER3.0950e-060.2805image
ENSG00000123159.14,GIPC1OVGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG3.1986e-050.2498image
ENSG00000123159.14,GIPC1PAADGSVA_HALLMARK_PEROXISOMEEAG3.1992e-020.2263image
ENSG00000123159.14,GIPC1PCPGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG7.4072e-08-0.4158image
ENSG00000123159.14,GIPC1PRADGSVA_HALLMARK_ANDROGEN_RESPONSEEAG2.7086e-02-0.2928image
ENSG00000123159.14,GIPC1SARCGSVA_HALLMARK_HYPOXIAEAG2.3733e-03-0.3852image
ENSG00000123159.14,GIPC1SKCMGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.0807e-020.1727image
chr19:14483177-14491511:-SKCMGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.8656e-040.2836image
ENSG00000123159.14,GIPC1STADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG4.8117e-080.2993image
chr19:14483177-14491511:-STADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER7.9995e-090.3164image
chr19:14480982-14481626:-STADGSVA_HALLMARK_APICAL_SURFACEEER4.8758e-020.2670image
ENSG00000123159.14,GIPC1TGCTGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG3.0704e-03-0.4997image
ENSG00000123159.14,GIPC1THCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG8.1164e-04-0.2751image
ENSG00000123159.14,GIPC1THYMGSVA_HALLMARK_MYC_TARGETS_V1EAG1.9151e-02-0.3887image
ENSG00000123159.14,GIPC1UCECGSVA_HALLMARK_UV_RESPONSE_DNEAG2.4882e-030.3536image
chr19:14483177-14491511:-UCECGSVA_HALLMARK_UV_RESPONSE_DNEER3.8981e-060.5688image


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7. Enriched editing regions and drugs for GIPC1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000123159.14,GIPC1ACCAZD6482EAG8.7067e-03-0.5338image
ENSG00000123159.14,GIPC1BLCAGefitinibEAG4.6679e-03-0.2291image
chr19:14483177-14491511:-BLCAGefitinibEER5.9294e-03-0.2374image
chr19:14483177-14491511:-BRCAAZD6482EER1.1330e-02-0.1078image
chr19:14480982-14481626:-BRCAAS601245EER3.6918e-02-0.2281image
ENSG00000123159.14,GIPC1BRCAAZD6482EAG3.4345e-03-0.1091image
ENSG00000123159.14,GIPC1CESCGDC.0449EAG1.7357e-050.3906image
chr19:14483177-14491511:-CESCGDC.0449EER8.6683e-050.3770image
chr19:14483177-14491511:-CHOLAS601245EER7.0873e-030.5691image
ENSG00000123159.14,GIPC1CHOLAS601245EAG4.3346e-020.4344image
chr19:14483177-14491511:-ESCACMKEER2.2459e-05-0.3284image
ENSG00000123159.14,GIPC1ESCACMKEAG2.0093e-05-0.3302image
chr19:14480982-14481626:-ESCABMS.754807EER2.5335e-02-0.2565image
chr19:14483177-14491511:-GBMLapatinibEER7.6685e-04-0.3622image
ENSG00000123159.14,GIPC1GBMBosutinibEAG1.4809e-03-0.3036image
chr19:14480982-14481626:-GBMJNJ.26854165EER1.2191e-020.5032image
ENSG00000123159.14,GIPC1HNSCGefitinibEAG1.0294e-02-0.3633image
chr19:14483177-14491511:-KIRCBAY.61.3606EER2.0999e-02-0.3551image
ENSG00000123159.14,GIPC1KIRCCI.1040EAG7.8996e-030.2799image
chr19:14483177-14491511:-KIRPGW.441756EER4.8397e-020.2864image
ENSG00000123159.14,GIPC1KIRPBAY.61.3606EAG5.0851e-03-0.3515image
chr19:14483177-14491511:-LGGBMS.509744EER1.0379e-020.1885image
ENSG00000123159.14,GIPC1LGGAKT.inhibitor.VIIIEAG5.0168e-050.1942image
ENSG00000123159.14,GIPC1LIHCAICAREAG1.3013e-050.4488image
chr19:14483177-14491511:-LUADAZD.2281EER3.1089e-02-0.1510image
chr19:14483177-14491511:-LUSCAZD6482EER2.0623e-03-0.2288image
ENSG00000123159.14,GIPC1LUSCAZD6482EAG6.8942e-05-0.2743image
ENSG00000123159.14,GIPC1MESOBortezomibEAG2.6099e-020.4442image
chr19:14483177-14491511:-OVBMS.536924EER1.9795e-04-0.2255image
chr19:14480982-14481626:-OVBI.2536EER3.0856e-020.2512image
ENSG00000123159.14,GIPC1OVBMS.536924EAG1.9307e-04-0.2246image
ENSG00000123159.14,GIPC1PAADABT.888EAG2.7232e-020.2341image
chr19:14483177-14491511:-PAADAZD6482EER4.6730e-02-0.2368image
ENSG00000123159.14,GIPC1PCPGBexaroteneEAG9.1516e-070.3823image
ENSG00000123159.14,GIPC1PRADCMKEAG2.6802e-03-0.3904image
ENSG00000123159.14,GIPC1SARCCGP.60474EAG2.5542e-030.3826image
ENSG00000123159.14,GIPC1SKCMGSK269962AEAG1.7764e-040.2524image
chr19:14483177-14491511:-SKCMElesclomolEER4.1874e-020.1567image
ENSG00000123159.14,GIPC1STADGemcitabineEAG2.0061e-05-0.2359image
chr19:14483177-14491511:-STADGemcitabineEER2.1645e-05-0.2357image
chr19:14480982-14481626:-STADCyclopamineEER1.1106e-02-0.3430image
ENSG00000123159.14,GIPC1TGCTGemcitabineEAG4.9556e-030.4775image
chr19:14483177-14491511:-THCAEHT.1864EER3.6936e-02-0.2241image
ENSG00000123159.14,GIPC1THCAGW843682XEAG5.2760e-03-0.2305image
ENSG00000123159.14,GIPC1THYMGemcitabineEAG1.5213e-030.5090image
ENSG00000123159.14,GIPC1UCECBMS.708163EAG2.7634e-03-0.3501image
chr19:14483177-14491511:-UCECBMS.708163EER2.2544e-03-0.3966image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType