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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: RN7SL737P (ImmuneEditome ID:106481123)

1. Gene summary of enriched editing regions for RN7SL737P

check button Gene summary
Gene informationGene symbol

RN7SL737P

Gene ID

106481123

GeneSynonyms-
GeneCytomap

12q22

GeneTypepseudo
GeneDescription-
GeneModificationdate20230329
UniprotID.
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr12:93507799-93509753:+ENST00000490246.2ENSG00000243015.2RN7SL737PncRNA_exonicAluJo,L1M5,7SLRNA,MLT1H,AluSp,AluSx1chr12:93507799-93509753:+.alignment


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2. Tumor-specific enriched editing regions for RN7SL737P


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr12:93507799-93509753:+ESCAEER4.4058e-021.9240e-021.0488e+02image

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3. Enriched editing regions and immune related genes for RN7SL737P


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr12:93507799-93509753:+GBMEERENSG00000152661,GJA10.27884.4597e-022.7673e-060.4130imageNFBL;FUSGJA1Macrophages_M0GSVA_HALLMARK_BILE_ACID_METABOLISM

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4. Enriched editing regions and immune related splicing for RN7SL737P


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000243015.2,RN7SL737P
ESCAEAGIRENSG00000006576.12chr777940018:77940302:77940527:779406590.40221.4379e-022.1800e-070.4627imageNNNADendritic_cells_restingGSVA_HALLMARK_HEDGEHOG_SIGNALING
ENSG00000243015.2,RN7SL737P
ESCAEAGMEXENSG00000177380.9chr1949148665:49148763:49148992:49149168:49149302:49149325:49149546:491497180.36994.3004e-028.4370e-060.4004imageNNNAMacrophages_M2
chr12:93507799-93509753:+
ESCAEERIRENSG00000173914.7chr1166675559:66677091:66677763:666778240.34304.6913e-021.5744e-060.4189imageNFAM120A;FBL;FUSNAGSVA_HALLMARK_ADIPOGENESIS
ENSG00000243015.2,RN7SL737P
ESCAEAGIRENSG00000185658.9chr2139296264:39296363:39298431:392985820.38044.3029e-023.9289e-060.4072imageNNNAT_cells_CD8GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr12:93507799-93509753:+
GBMEERMEXENSG00000129657.10chr1777215831:77215844:77215896:77216270:77216270:77216296:77216335:772163480.31952.7934e-028.2525e-060.4275imageNFAM120A;FBL;FUSNAMonocytes

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5. Enriched editing regions and immune infiltration for RN7SL737P


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr12:93507799-93509753:+BRCAEERNK_cells_resting5.3054e-03-0.1466image
ENSG00000243015.2,RN7SL737PBRCAEAGT_cells_regulatory_(Tregs)4.3918e-030.1557image
chr12:93507799-93509753:+CESCEERMast_cells_resting4.1145e-020.2502image
ENSG00000243015.2,RN7SL737PCESCEAGMast_cells_resting3.6208e-020.2604image
chr12:93507799-93509753:+ESCAEERDendritic_cells_resting4.4054e-03-0.2492image
ENSG00000243015.2,RN7SL737PESCAEAGDendritic_cells_resting4.8029e-02-0.1809image
chr12:93507799-93509753:+HNSCEERNK_cells_resting4.6295e-020.2562image
ENSG00000243015.2,RN7SL737PHNSCEAGNK_cells_resting4.9221e-020.2529image
ENSG00000243015.2,RN7SL737PKICHEAGB_cells_memory4.7657e-020.4082image
chr12:93507799-93509753:+KIRCEERMacrophages_M05.4241e-030.1764image
ENSG00000243015.2,RN7SL737PKIRCEAGMacrophages_M03.3285e-020.1383image
chr12:93507799-93509753:+KIRPEERDendritic_cells_resting4.9942e-02-0.1480image
ENSG00000243015.2,RN7SL737PLAMLEAGMacrophages_M01.2122e-020.4522image
chr12:93507799-93509753:+LGGEERT_cells_follicular_helper2.0001e-02-0.1095image
ENSG00000243015.2,RN7SL737PLGGEAGT_cells_follicular_helper3.8714e-02-0.0993image
chr12:93507799-93509753:+LUADEERDendritic_cells_activated3.8247e-030.2220image
ENSG00000243015.2,RN7SL737PLUADEAGDendritic_cells_activated4.5500e-030.2198image
chr12:93507799-93509753:+LUSCEERNeutrophils3.0424e-020.1885image
ENSG00000243015.2,RN7SL737PLUSCEAGNK_cells_activated2.2063e-020.2022image
chr12:93507799-93509753:+OVEERMacrophages_M14.1433e-020.1517image
ENSG00000243015.2,RN7SL737POVEAGNK_cells_activated8.8717e-030.2063image
ENSG00000243015.2,RN7SL737PPAADEAGNK_cells_resting4.1728e-020.3873image
chr12:93507799-93509753:+PCPGEERT_cells_CD82.7009e-020.2109image
ENSG00000243015.2,RN7SL737PPCPGEAGT_cells_CD81.8058e-020.2251image
ENSG00000243015.2,RN7SL737PPRADEAGT_cells_gamma_delta2.5616e-020.1559image
ENSG00000243015.2,RN7SL737PREADEAGPlasma_cells4.3051e-03-0.4586image
chr12:93507799-93509753:+SARCEERT_cells_CD81.5402e-030.3273image
ENSG00000243015.2,RN7SL737PSARCEAGT_cells_CD81.4920e-030.3318image
chr12:93507799-93509753:+STADEERT_cells_gamma_delta1.2994e-02-0.1485image
ENSG00000243015.2,RN7SL737PSTADEAGNK_cells_activated2.4675e-030.1958image
chr12:93507799-93509753:+THCAEERT_cells_CD4_memory_activated7.7620e-030.2091image
ENSG00000243015.2,RN7SL737PTHCAEAGT_cells_CD4_memory_activated2.3983e-020.1831image
chr12:93507799-93509753:+UCECEERMast_cells_activated6.4682e-030.4579image
ENSG00000243015.2,RN7SL737PUCECEAGMast_cells_activated7.3070e-030.4518image


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6. Enriched editing regions and immune gene sets for RN7SL737P


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000243015.2,RN7SL737PPAADEAG2.5201e-020.42223.0124e-020.41031.8386e-020.44251.1671e-020.4697image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000243015.2,RN7SL737PACCGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.6560e-020.4570image
chr12:93507799-93509753:+BLCAGSVA_HALLMARK_HYPOXIAEER2.1294e-040.3829image
ENSG00000243015.2,RN7SL737PBLCAGSVA_HALLMARK_APOPTOSISEAG2.5736e-040.3866image
chr12:93507799-93509753:+BRCAGSVA_HALLMARK_PEROXISOMEEER3.1112e-070.2657image
ENSG00000243015.2,RN7SL737PBRCAGSVA_HALLMARK_GLYCOLYSISEAG8.6700e-090.3088image
chr12:93507799-93509753:+CESCGSVA_HALLMARK_BILE_ACID_METABOLISMEER3.7030e-030.3499image
ENSG00000243015.2,RN7SL737PCESCGSVA_HALLMARK_ADIPOGENESISEAG1.8548e-030.3789image
ENSG00000243015.2,RN7SL737PCOADGSVA_HALLMARK_P53_PATHWAYEAG4.9902e-020.1919image
chr12:93507799-93509753:+ESCAGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.9179e-02-0.2060image
ENSG00000243015.2,RN7SL737PESCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.0601e-02-0.2325image
chr12:93507799-93509753:+GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEER5.5640e-030.2516image
ENSG00000243015.2,RN7SL737PGBMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG9.1315e-040.3064image
chr12:93507799-93509753:+HNSCGSVA_HALLMARK_PROTEIN_SECRETIONEER3.2108e-030.3714image
ENSG00000243015.2,RN7SL737PHNSCGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.4605e-030.3987image
ENSG00000243015.2,RN7SL737PKICHGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG9.4244e-03-0.5186image
chr12:93507799-93509753:+KIRCGSVA_HALLMARK_DNA_REPAIREER2.1665e-020.1461image
ENSG00000243015.2,RN7SL737PKIRCGSVA_HALLMARK_DNA_REPAIREAG2.3524e-020.1471image
chr12:93507799-93509753:+KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEER3.9520e-03-0.2162image
ENSG00000243015.2,RN7SL737PKIRPGSVA_HALLMARK_MITOTIC_SPINDLEEAG7.5556e-03-0.2030image
ENSG00000243015.2,RN7SL737PLGGGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG9.6982e-050.1860image
chr12:93507799-93509753:+LGGGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER1.3298e-050.2035image
ENSG00000243015.2,RN7SL737PLIHCGSVA_HALLMARK_PEROXISOMEEAG1.4281e-020.3412image
chr12:93507799-93509753:+LIHCGSVA_HALLMARK_HEME_METABOLISMEER1.2248e-020.3418image
ENSG00000243015.2,RN7SL737PLUADGSVA_HALLMARK_PEROXISOMEEAG7.4890e-030.2075image
chr12:93507799-93509753:+LUADGSVA_HALLMARK_PEROXISOMEEER7.1831e-030.2067image
chr12:93507799-93509753:+LUSCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER4.1327e-040.3030image
ENSG00000243015.2,RN7SL737PLUSCGSVA_HALLMARK_MYC_TARGETS_V2EAG1.5990e-03-0.2762image
chr12:93507799-93509753:+OVGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER8.9149e-040.2449image
ENSG00000243015.2,RN7SL737POVGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.3691e-030.2387image
ENSG00000243015.2,RN7SL737PPAADGSVA_HALLMARK_HYPOXIAEAG1.1671e-020.4697image
ENSG00000243015.2,RN7SL737PPCPGGSVA_HALLMARK_IL2_STAT5_SIGNALINGEAG4.0053e-030.2723image
chr12:93507799-93509753:+PCPGGSVA_HALLMARK_IL2_STAT5_SIGNALINGEER6.7683e-030.2568image
ENSG00000243015.2,RN7SL737PPRADGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.3757e-05-0.2985image
ENSG00000243015.2,RN7SL737PREADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG6.3058e-03-0.4409image
chr12:93507799-93509753:+SARCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER4.4731e-020.2110image
ENSG00000243015.2,RN7SL737PSARCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.4585e-020.2382image
ENSG00000243015.2,RN7SL737PSKCMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.6041e-020.2142image
chr12:93507799-93509753:+SKCMGSVA_HALLMARK_UV_RESPONSE_UPEER1.1621e-020.2174image
ENSG00000243015.2,RN7SL737PSTADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG6.3905e-030.1767image
ENSG00000243015.2,RN7SL737PTGCTGSVA_HALLMARK_KRAS_SIGNALING_UPEAG1.9087e-020.3408image
chr12:93507799-93509753:+THCAGSVA_HALLMARK_MYC_TARGETS_V2EER2.7114e-020.1742image
ENSG00000243015.2,RN7SL737PTHCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG3.3400e-020.1727image
ENSG00000243015.2,RN7SL737PTHYMGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG4.5323e-040.4732image
ENSG00000243015.2,RN7SL737PUCECGSVA_HALLMARK_UV_RESPONSE_DNEAG1.0525e-02-0.4330image
chr12:93507799-93509753:+UCECGSVA_HALLMARK_UV_RESPONSE_DNEER1.4082e-02-0.4173image


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7. Enriched editing regions and drugs for RN7SL737P


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000243015.2,RN7SL737PACCCyclopamineEAG5.2182e-030.5221image
ENSG00000243015.2,RN7SL737PBLCAKIN001.135EAG3.0351e-03-0.3178image
chr12:93507799-93509753:+BLCAKIN001.135EER1.3694e-03-0.3342image
ENSG00000243015.2,RN7SL737PBRCAGNF.2EAG1.0110e-05-0.2393image
chr12:93507799-93509753:+BRCAGNF.2EER3.6490e-04-0.1868image
chr12:93507799-93509753:+CESCJW.7.52.1EER3.4946e-02-0.2581image
ENSG00000243015.2,RN7SL737PCOADDocetaxelEAG1.2223e-02-0.2437image
chr12:93507799-93509753:+COADCEP.701EER7.7698e-03-0.2537image
chr12:93507799-93509753:+ESCACHIR.99021EER5.9596e-030.2409image
ENSG00000243015.2,RN7SL737PESCAAMG.706EAG8.1095e-04-0.3030image
ENSG00000243015.2,RN7SL737PGBMErlotinibEAG1.2187e-03-0.2993image
chr12:93507799-93509753:+GBMErlotinibEER3.4286e-03-0.2651image
ENSG00000243015.2,RN7SL737PHNSCCI.1040EAG1.8423e-02-0.3010image
chr12:93507799-93509753:+HNSCCI.1040EER3.3094e-02-0.2733image
ENSG00000243015.2,RN7SL737PKICHCGP.082996EAG8.3084e-03-0.5259image
ENSG00000243015.2,RN7SL737PKIRCBMS.708163EAG1.2279e-030.2088image
chr12:93507799-93509753:+KIRCAZD6482EER9.5203e-040.2098image
chr12:93507799-93509753:+KIRPAMG.706EER9.8780e-03-0.1940image
ENSG00000243015.2,RN7SL737PKIRPAMG.706EAG8.8903e-03-0.1989image
ENSG00000243015.2,RN7SL737PLGGJNK.Inhibitor.VIIIEAG2.6469e-050.2002image
chr12:93507799-93509753:+LGGMG.132EER9.4062e-06-0.2069image
chr12:93507799-93509753:+LUADAxitinibEER7.7933e-030.2046image
ENSG00000243015.2,RN7SL737PLUADAxitinibEAG2.5759e-020.1736image
chr12:93507799-93509753:+LUSCAZD8055EER1.5830e-030.2723image
ENSG00000243015.2,RN7SL737PLUSCAZD8055EAG1.9753e-040.3233image
ENSG00000243015.2,RN7SL737PMESOKU.55933EAG4.7950e-020.3274image
chr12:93507799-93509753:+MESOAxitinibEER2.1131e-020.3778image
chr12:93507799-93509753:+OVDasatinibEER1.7451e-04-0.2762image
ENSG00000243015.2,RN7SL737POVDasatinibEAG5.5987e-06-0.3514image
ENSG00000243015.2,RN7SL737PPAADAUY922EAG1.7863e-02-0.4443image
ENSG00000243015.2,RN7SL737PPCPGAZD.2281EAG6.9234e-04-0.3186image
chr12:93507799-93509753:+PCPGAZD.2281EER2.1999e-04-0.3453image
ENSG00000243015.2,RN7SL737PPRADBMS.509744EAG1.6980e-05-0.2955image
ENSG00000243015.2,RN7SL737PREADJNK.9LEAG2.0369e-02-0.3799image
chr12:93507799-93509753:+SARCCCT007093EER3.5077e-020.2212image
ENSG00000243015.2,RN7SL737PSARCCCT007093EAG2.0495e-020.2453image
chr12:93507799-93509753:+SKCMABT.263EER1.1067e-020.2189image
ENSG00000243015.2,RN7SL737PSKCMMG.132EAG8.8904e-03-0.2331image
ENSG00000243015.2,RN7SL737PSTADBAY.61.3606EAG2.7640e-050.2687image
chr12:93507799-93509753:+STADBAY.61.3606EER6.5193e-050.2367image
ENSG00000243015.2,RN7SL737PTGCTFH535EAG7.9202e-030.3828image
chr12:93507799-93509753:+THCAImatinibEER7.9071e-030.2086image
ENSG00000243015.2,RN7SL737PTHCACI.1040EAG7.7082e-03-0.2154image
ENSG00000243015.2,RN7SL737PTHYMBMS.509744EAG1.5337e-03-0.4323image
ENSG00000243015.2,RN7SL737PUCECEmbelinEAG6.6279e-040.5547image
chr12:93507799-93509753:+UCECEmbelinEER1.0411e-030.5376image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType