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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: PAICS (ImmuneEditome ID:10606)

1. Gene summary of enriched editing regions for PAICS

check button Gene summary
Gene informationGene symbol

PAICS

Gene ID

10606

GeneSynonymsADE2|ADE2H1|AIRC|PAICSD|PAIS
GeneCytomap

4q12

GeneTypeprotein-coding
GeneDescriptionbifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase|AIR carboxylase|SAICAR synthetase|multifunctional protein ADE2|multifunctional protein ADE2H1|phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase|phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase
GeneModificationdate20230518
UniprotIDP22234;D6RF62;E9PBS1
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr4:56459892-56460985:+ENST00000264221.5ENSG00000128050.7PAICSUTR3AluSx1,Charlie4z,L2a,AluJrchr4:56459892-56460985:+.alignment
chr4:56459892-56460985:+ENST00000399688.6ENSG00000128050.7PAICSUTR3AluSx1,Charlie4z,L2a,AluJrchr4:56459892-56460985:+.alignment
chr4:56459892-56460985:+ENST00000512576.2ENSG00000128050.7PAICSUTR3AluSx1,Charlie4z,L2a,AluJrchr4:56459892-56460985:+.alignment
chr4:56459892-56460985:+ENST00000514888.4ENSG00000128050.7PAICSUTR3AluSx1,Charlie4z,L2a,AluJrchr4:56459892-56460985:+.alignment
chr4:56462702-56463663:+ENST00000512576.2ENSG00000128050.7PAICSUTR3AluSpchr4:56462702-56463663:+.alignment


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2. Tumor-specific enriched editing regions for PAICS


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr4:56459892-56460985:+BRCAEER6.6903e-11image
ENSG00000128050.7,PAICSBRCAEAG6.9213e-11image
chr4:56459892-56460985:+COADEER9.0514e-13image
ENSG00000128050.7,PAICSCOADEAG8.3862e-13image
chr4:56459892-56460985:+HNSCEER2.3735e-11image
ENSG00000128050.7,PAICSHNSCEAG2.2763e-11image
chr4:56459892-56460985:+KICHEER3.2927e-04image
ENSG00000128050.7,PAICSKICHEAG3.2747e-04image
chr4:56459892-56460985:+KIRCEER1.5063e-03image
ENSG00000128050.7,PAICSKIRCEAG1.5418e-03image
chr4:56459892-56460985:+KIRPEER3.7800e-03image
ENSG00000128050.7,PAICSKIRPEAG3.7583e-03image
chr4:56459892-56460985:+LIHCEER7.8789e-04image
ENSG00000128050.7,PAICSLIHCEAG7.5232e-04image
chr4:56459892-56460985:+LUADEER1.6655e-04image
ENSG00000128050.7,PAICSLUADEAG1.6413e-04image
chr4:56459892-56460985:+LUSCEER3.2738e-07image
ENSG00000128050.7,PAICSLUSCEAG3.2964e-07image
chr4:56459892-56460985:+PRADEER3.7498e-02image
ENSG00000128050.7,PAICSPRADEAG3.8959e-02image
chr4:56459892-56460985:+STADEER2.6332e-02image
ENSG00000128050.7,PAICSSTADEAG2.4605e-02image
chr4:56459892-56460985:+THCAEER1.9626e-05image
ENSG00000128050.7,PAICSTHCAEAG2.0517e-05image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr4:56459892-56460985:+BRCAPathEER2.3319e-032.7535e-030.0910image
ENSG00000128050.7,PAICSBRCAPathEAG2.4691e-032.8046e-030.0908image
chr4:56459892-56460985:+CESCCliEER4.2389e-046.3859e-05-0.2318image
ENSG00000128050.7,PAICSCESCCliEAG3.1453e-043.9298e-05-0.2378image
chr4:56459892-56460985:+ESCAPathEER3.7948e-023.8069e-020.1736image
ENSG00000128050.7,PAICSESCAPathEAG3.9337e-024.0473e-020.1716image
ENSG00000128050.7,PAICSHNSCCliEAG2.0714e-022.8435e-030.1361image
chr4:56459892-56460985:+HNSCCliEER2.1514e-022.9835e-030.1356image
ENSG00000128050.7,PAICSKIRCPathEAG2.1910e-062.8952e-060.2012image
chr4:56459892-56460985:+KIRCPathEER2.1454e-062.9332e-060.2011image
ENSG00000128050.7,PAICSLUSCPathEAG2.8992e-052.8438e-030.1337image
chr4:56459892-56460985:+LUSCPathEER3.2413e-052.9563e-030.1333image
chr4:56459892-56460985:+THCAPathEER3.6159e-052.1137e-030.1370image
ENSG00000128050.7,PAICSTHCAPathEAG3.9451e-052.2598e-030.1361image
ENSG00000128050.7,PAICSUCSCliEAG7.5227e-033.1943e-03-0.3906image
chr4:56459892-56460985:+UCSCliEER7.4550e-033.0757e-03-0.3920image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for PAICS


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr4:56459892-56460985:+LIHCEERENSG00000116586,LAMTOR20.39341.3493e-111.5450e-170.4225imageNNNANK_cells_activatedGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr4:56459892-56460985:+CESCEERENSG00000121060,TRIM25-0.46233.8109e-134.8588e-19-0.4863imageNNTRIM25T_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
chr4:56459892-56460985:+CESCEERENSG00000274211,SOCS7-0.46081.2577e-129.6619e-17-0.4571imageNNNAMacrophages_M0GSVA_HALLMARK_MITOTIC_SPINDLE
chr4:56459892-56460985:+CESCEERENSG00000174151,CYB561D1-0.44263.3655e-122.8758e-19-0.4891imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr4:56459892-56460985:+CESCEERENSG00000175970,UNC119B-0.44113.8970e-111.9774e-14-0.4246imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr4:56459892-56460985:+CESCEERENSG00000152102,FAM168B-0.42644.5739e-104.5995e-15-0.4339imageNNNAMacrophages_M0GSVA_HALLMARK_MITOTIC_SPINDLE
chr4:56459892-56460985:+CESCEERENSG00000124164,VAPB-0.40342.9436e-093.6287e-13-0.4052imageNNNAB_cells_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
chr4:56459892-56460985:+CESCEERENSG00000109971,HSPA8-0.37575.5269e-085.2789e-13-0.4027imageNNHSPA8Mast_cells_restingGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSE
chr4:56459892-56460985:+HNSCEERENSG00000174151,CYB561D1-0.42253.2605e-191.3795e-22-0.4217imageNNNAMacrophages_M1GSVA_HALLMARK_HYPOXIA
chr4:56459892-56460985:+THCAEERENSG00000188846,RPL140.39027.8524e-171.0048e-220.4187imageNNNANK_cells_activatedGSVA_HALLMARK_HEME_METABOLISM
chr4:56459892-56460985:+LIHCEERENSG00000116586,LAMTOR20.39341.3493e-111.5450e-170.4225imageNNNANK_cells_activatedGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr4:56459892-56460985:+CESCEERENSG00000121060,TRIM25-0.46233.8109e-134.8588e-19-0.4863imageNNTRIM25T_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
chr4:56459892-56460985:+CESCEERENSG00000274211,SOCS7-0.46081.2577e-129.6619e-17-0.4571imageNNNAMacrophages_M0GSVA_HALLMARK_MITOTIC_SPINDLE
chr4:56459892-56460985:+CESCEERENSG00000174151,CYB561D1-0.44263.3655e-122.8758e-19-0.4891imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr4:56459892-56460985:+CESCEERENSG00000175970,UNC119B-0.44113.8970e-111.9774e-14-0.4246imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr4:56459892-56460985:+CESCEERENSG00000152102,FAM168B-0.42644.5739e-104.5995e-15-0.4339imageNNNAMacrophages_M0GSVA_HALLMARK_MITOTIC_SPINDLE
chr4:56459892-56460985:+CESCEERENSG00000124164,VAPB-0.40342.9436e-093.6287e-13-0.4052imageNNNAB_cells_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
chr4:56459892-56460985:+CESCEERENSG00000109971,HSPA8-0.37575.5269e-085.2789e-13-0.4027imageNNHSPA8Mast_cells_restingGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSE
chr4:56459892-56460985:+HNSCEERENSG00000174151,CYB561D1-0.42253.2605e-191.3795e-22-0.4217imageNNNAMacrophages_M1GSVA_HALLMARK_HYPOXIA
chr4:56459892-56460985:+THCAEERENSG00000188846,RPL140.39027.8524e-171.0048e-220.4187imageNNNANK_cells_activatedGSVA_HALLMARK_HEME_METABOLISM
chr4:56459892-56460985:+LIHCEERENSG00000116586,LAMTOR20.39341.3493e-111.5450e-170.4225imageNNNANK_cells_activatedGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr4:56459892-56460985:+CESCEERENSG00000121060,TRIM25-0.46233.8109e-134.8588e-19-0.4863imageNNTRIM25T_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
chr4:56459892-56460985:+CESCEERENSG00000274211,SOCS7-0.46081.2577e-129.6619e-17-0.4571imageNNNAMacrophages_M0GSVA_HALLMARK_MITOTIC_SPINDLE
chr4:56459892-56460985:+CESCEERENSG00000174151,CYB561D1-0.44263.3655e-122.8758e-19-0.4891imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr4:56459892-56460985:+CESCEERENSG00000175970,UNC119B-0.44113.8970e-111.9774e-14-0.4246imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr4:56459892-56460985:+CESCEERENSG00000152102,FAM168B-0.42644.5739e-104.5995e-15-0.4339imageNNNAMacrophages_M0GSVA_HALLMARK_MITOTIC_SPINDLE
chr4:56459892-56460985:+CESCEERENSG00000124164,VAPB-0.40342.9436e-093.6287e-13-0.4052imageNNNAB_cells_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
chr4:56459892-56460985:+CESCEERENSG00000109971,HSPA8-0.37575.5269e-085.2789e-13-0.4027imageNNHSPA8Mast_cells_restingGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSE
chr4:56459892-56460985:+HNSCEERENSG00000174151,CYB561D1-0.42253.2605e-191.3795e-22-0.4217imageNNNAMacrophages_M1GSVA_HALLMARK_HYPOXIA
chr4:56459892-56460985:+THCAEERENSG00000188846,RPL140.39027.8524e-171.0048e-220.4187imageNNNANK_cells_activatedGSVA_HALLMARK_HEME_METABOLISM
chr4:56459892-56460985:+LIHCEERENSG00000116586,LAMTOR20.39341.3493e-111.5450e-170.4225imageNNNANK_cells_activatedGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr4:56459892-56460985:+CESCEERENSG00000121060,TRIM25-0.46233.8109e-134.8588e-19-0.4863imageNNTRIM25T_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
chr4:56459892-56460985:+CESCEERENSG00000274211,SOCS7-0.46081.2577e-129.6619e-17-0.4571imageNNNAMacrophages_M0GSVA_HALLMARK_MITOTIC_SPINDLE
chr4:56459892-56460985:+CESCEERENSG00000174151,CYB561D1-0.44263.3655e-122.8758e-19-0.4891imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr4:56459892-56460985:+CESCEERENSG00000175970,UNC119B-0.44113.8970e-111.9774e-14-0.4246imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr4:56459892-56460985:+CESCEERENSG00000152102,FAM168B-0.42644.5739e-104.5995e-15-0.4339imageNNNAMacrophages_M0GSVA_HALLMARK_MITOTIC_SPINDLE
chr4:56459892-56460985:+CESCEERENSG00000124164,VAPB-0.40342.9436e-093.6287e-13-0.4052imageNNNAB_cells_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
chr4:56459892-56460985:+CESCEERENSG00000109971,HSPA8-0.37575.5269e-085.2789e-13-0.4027imageNNHSPA8Mast_cells_restingGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSE
chr4:56459892-56460985:+HNSCEERENSG00000174151,CYB561D1-0.42253.2605e-191.3795e-22-0.4217imageNNNAMacrophages_M1GSVA_HALLMARK_HYPOXIA
chr4:56459892-56460985:+THCAEERENSG00000188846,RPL140.39027.8524e-171.0048e-220.4187imageNNNANK_cells_activatedGSVA_HALLMARK_HEME_METABOLISM

More results



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4. Enriched editing regions and immune related splicing for PAICS


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000128050.7,PAICS
BLCAEAGIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.42853.8012e-141.4999e-19-0.4328imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CBX7;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184PRKCSHMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr4:56459892-56460985:+
BLCAEERIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.44898.7136e-168.2380e-23-0.4672imageNNPRKCSHMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000128050.7,PAICS
CESCEAGIRENSG00000117616.13chr125243549:25244498:25245149:25245208-0.37811.3352e-071.6114e-13-0.4200imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28B;LSM11;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZC3H7B;ZNF184NAT_cells_CD4_memory_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000128050.7,PAICS
CESCEAGIRENSG00000184857.7chr168795179:8796590:8797611:8797642-0.37951.3909e-072.9591e-12-0.4060imageNAIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;NONO;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RTCB;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZNF184NADendritic_cells_activatedGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
ENSG00000128050.7,PAICS
CESCEAGIRENSG00000166012.10chr1193732243:93733397:93734624:93734660-0.39251.7809e-071.9663e-13-0.4094imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL14;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAB_cells_naiveGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
ENSG00000128050.7,PAICS
CESCEAGIRENSG00000168672.3chr8126552814:126553503:126556264:126556271-0.38462.0128e-071.0849e-12-0.4066imageNADAR;AIFM1;ALYREF;BCCIP;CAPRIN1;CELF2;CSTF2T;DDX54;DGCR8;EIF4A3;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR2;HNRNPA1;HNRNPC;HNRNPD;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;LIN28;LIN28A;LIN28B;MBNL2;MOV10;NUMA1;PCBP2;PRPF8;RANGAP1;RBFOX2;RBM47;RNF219;RTCB;SRSF1;SRSF3;TIA1;TIAL1;U2AF2;UPF1;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
ENSG00000128050.7,PAICS
CESCEAGIRENSG00000089280.14chr1631184938:31185179:31188324:31188357-0.37422.2350e-077.4545e-16-0.4478imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAT_cells_CD4_memory_activatedGSVA_HALLMARK_APOPTOSIS
chr4:56459892-56460985:+
CESCEERIRENSG00000132199.14chr18690548:691276:692769:693175-0.22474.0768e-032.6562e-10-0.4112imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_APOPTOSIS
ENSG00000128050.7,PAICS
CESCEAGIRENSG00000132199.14chr18690548:691276:692769:693175-0.22174.6976e-032.7812e-10-0.4099imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAT_cells_CD4_memory_activatedGSVA_HALLMARK_APOPTOSIS
ENSG00000128050.7,PAICS
CESCEAGIRENSG00000117616.13chr125243549:25243633:25244453:25244498-0.36766.3684e-075.3108e-14-0.4208imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28B;LSM11;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZC3H7B;ZNF184NAT_cells_CD4_memory_activatedGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY

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5. Enriched editing regions and immune infiltration for PAICS


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr4:56459892-56460985:+ACCEERB_cells_memory1.7500e-020.2667image
ENSG00000128050.7,PAICSACCEAGB_cells_memory1.7586e-020.2665image
chr4:56459892-56460985:+BLCAEERMacrophages_M11.2505e-020.1256image
ENSG00000128050.7,PAICSBLCAEAGMacrophages_M12.5717e-020.1119image
chr4:56459892-56460985:+BRCAEERNK_cells_activated4.3769e-050.1238image
chr4:56462702-56463663:+BRCAEERMacrophages_M13.8751e-020.1947image
ENSG00000128050.7,PAICSBRCAEAGNK_cells_activated4.4572e-050.1237image
chr4:56459892-56460985:+CESCEERT_cells_CD85.7203e-040.1987image
ENSG00000128050.7,PAICSCESCEAGT_cells_CD85.2935e-040.1996image
chr4:56459892-56460985:+CHOLEERT_cells_CD4_naive1.1434e-020.4226image
ENSG00000128050.7,PAICSCHOLEAGT_cells_CD4_naive1.1434e-020.4226image
chr4:56459892-56460985:+COADEERMacrophages_M15.6148e-030.1663image
ENSG00000128050.7,PAICSCOADEAGMacrophages_M15.5651e-030.1665image
chr4:56459892-56460985:+ESCAEERT_cells_regulatory_(Tregs)7.5704e-03-0.2104image
chr4:56462702-56463663:+ESCAEERT_cells_gamma_delta2.8631e-020.3462image
ENSG00000128050.7,PAICSESCAEAGT_cells_regulatory_(Tregs)8.9165e-03-0.2061image
chr4:56459892-56460985:+GBMEERB_cells_naive2.1672e-03-0.2357image
chr4:56462702-56463663:+GBMEERMacrophages_M02.1744e-02-0.2701image
ENSG00000128050.7,PAICSGBMEAGB_cells_naive3.0022e-03-0.2283image
chr4:56459892-56460985:+HNSCEERMacrophages_M12.2322e-030.1377image
ENSG00000128050.7,PAICSHNSCEAGMacrophages_M12.4162e-030.1365image
chr4:56459892-56460985:+KICHEERT_cells_gamma_delta1.4743e-040.4537image
ENSG00000128050.7,PAICSKICHEAGT_cells_gamma_delta1.4743e-040.4537image
chr4:56459892-56460985:+KIRCEERMacrophages_M28.5626e-05-0.1991image
ENSG00000128050.7,PAICSKIRCEAGMacrophages_M28.2866e-05-0.1995image
chr4:56459892-56460985:+LAMLEERMast_cells_resting9.4851e-03-0.2126image
ENSG00000128050.7,PAICSLAMLEAGMast_cells_resting7.5619e-03-0.2188image
chr4:56459892-56460985:+LGGEERMacrophages_M01.3738e-12-0.3016image
ENSG00000128050.7,PAICSLGGEAGMacrophages_M01.4610e-12-0.3013image
chr4:56459892-56460985:+LIHCEERMacrophages_M02.3711e-03-0.1571image
ENSG00000128050.7,PAICSLIHCEAGMacrophages_M04.8918e-03-0.1456image
chr4:56459892-56460985:+LUADEERT_cells_gamma_delta1.2971e-030.1416image
ENSG00000128050.7,PAICSLUADEAGT_cells_gamma_delta1.3100e-030.1415image
chr4:56459892-56460985:+LUSCEERT_cells_CD82.7951e-040.1625image
ENSG00000128050.7,PAICSLUSCEAGT_cells_CD4_memory_activated2.9432e-040.1617image
chr4:56459892-56460985:+MESOEERT_cells_CD4_naive8.7198e-03-0.2896image
ENSG00000128050.7,PAICSMESOEAGT_cells_CD4_naive8.6593e-03-0.2899image
chr4:56459892-56460985:+OVEERMacrophages_M21.4703e-03-0.1859image
ENSG00000128050.7,PAICSOVEAGMacrophages_M21.3448e-03-0.1874image
chr4:56459892-56460985:+PAADEERNK_cells_resting6.2948e-050.2953image
ENSG00000128050.7,PAICSPAADEAGNK_cells_resting6.1770e-050.2956image
chr4:56459892-56460985:+PCPGEERT_cells_CD4_memory_resting1.1892e-03-0.2378image
ENSG00000128050.7,PAICSPCPGEAGT_cells_CD4_memory_resting1.1795e-03-0.2380image
chr4:56459892-56460985:+PRADEERMacrophages_M22.5671e-04-0.1631image
ENSG00000128050.7,PAICSPRADEAGMacrophages_M22.4105e-04-0.1638image
chr4:56459892-56460985:+READEERT_cells_CD4_memory_activated1.1319e-03-0.3307image
ENSG00000128050.7,PAICSREADEAGT_cells_CD4_memory_activated7.7776e-04-0.3390image
chr4:56459892-56460985:+SARCEERT_cells_gamma_delta3.2131e-050.2577image
ENSG00000128050.7,PAICSSARCEAGT_cells_gamma_delta3.6474e-050.2560image
chr4:56459892-56460985:+SKCMEERMast_cells_activated3.1061e-06-0.2152image
ENSG00000128050.7,PAICSSKCMEAGMast_cells_activated2.0712e-05-0.1960image
chr4:56459892-56460985:+STADEERT_cells_CD4_memory_activated4.4713e-050.2100image
chr4:56462702-56463663:+STADEERMast_cells_resting1.2339e-020.3784image
ENSG00000128050.7,PAICSSTADEAGT_cells_CD4_memory_activated3.8917e-050.2116image
chr4:56459892-56460985:+TGCTEERMacrophages_M24.9492e-10-0.4761image
ENSG00000128050.7,PAICSTGCTEAGMacrophages_M25.1336e-10-0.4758image
chr4:56459892-56460985:+THCAEERT_cells_CD89.8519e-03-0.1151image
ENSG00000128050.7,PAICSTHCAEAGT_cells_CD81.0088e-02-0.1147image
chr4:56459892-56460985:+THYMEERMacrophages_M11.0173e-120.5986image
ENSG00000128050.7,PAICSTHYMEAGMacrophages_M11.1668e-120.5974image
chr4:56459892-56460985:+UCECEERT_cells_regulatory_(Tregs)9.8346e-040.2477image
ENSG00000128050.7,PAICSUCECEAGT_cells_regulatory_(Tregs)1.6467e-030.2362image
chr4:56459892-56460985:+UCSEERMacrophages_M02.1562e-020.3093image
ENSG00000128050.7,PAICSUCSEAGMacrophages_M02.1547e-020.3094image
chr4:56459892-56460985:+UVMEERT_cells_CD82.1249e-020.2572image
ENSG00000128050.7,PAICSUVMEAGT_cells_CD82.1249e-020.2572image


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6. Enriched editing regions and immune gene sets for PAICS


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000128050.7,PAICSLGGEAG2.1354e-03-0.13322.0067e-12-0.29951.1542e-04-0.16691.7811e-020.1030image
chr4:56459892-56460985:+LGGEER1.8831e-03-0.13481.2340e-12-0.30221.0257e-04-0.16811.7626e-020.1032image
ENSG00000128050.7,PAICSTHYMEAG1.7463e-06-0.42541.6367e-08-0.49306.8480e-040.30952.5940e-080.4869image
chr4:56459892-56460985:+THYMEER1.7027e-06-0.42581.7668e-08-0.49206.2019e-040.31182.2544e-080.4888image
ENSG00000128050.7,PAICSUCECEAG1.4244e-02-0.18502.3444e-02-0.17134.5485e-03-0.21354.8652e-02-0.1493image
chr4:56459892-56460985:+UCECEER9.0282e-03-0.19741.7642e-02-0.17972.2884e-03-0.22984.3479e-02-0.1533image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000128050.7,PAICSBLCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG8.9868e-04-0.1660image
chr4:56459892-56460985:+BLCAGSVA_HALLMARK_MITOTIC_SPINDLEEER7.6109e-04-0.1687image
chr4:56462702-56463663:+BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.1869e-020.1918image
ENSG00000128050.7,PAICSBRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.2934e-110.2013image
chr4:56459892-56460985:+BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.4581e-110.2033image
ENSG00000128050.7,PAICSCESCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG3.1540e-050.2386image
chr4:56459892-56460985:+CESCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.2099e-05-0.2388image
chr4:56459892-56460985:+CHOLGSVA_HALLMARK_ANGIOGENESISEER3.3768e-03-0.4819image
ENSG00000128050.7,PAICSCHOLGSVA_HALLMARK_ANGIOGENESISEAG3.3768e-03-0.4819image
chr4:56459892-56460985:+COADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.7110e-030.1880image
ENSG00000128050.7,PAICSCOADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.7230e-030.1878image
ENSG00000128050.7,PAICSDLBCGSVA_HALLMARK_HYPOXIAEAG4.1414e-020.3088image
chr4:56459892-56460985:+DLBCGSVA_HALLMARK_HYPOXIAEER4.0944e-020.3095image
ENSG00000128050.7,PAICSESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.5017e-04-0.2792image
chr4:56462702-56463663:+ESCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER3.6565e-040.5359image
chr4:56459892-56460985:+ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER3.2497e-04-0.2806image
chr4:56459892-56460985:+GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEER7.2443e-040.2590image
ENSG00000128050.7,PAICSGBMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG8.4128e-040.2560image
chr4:56462702-56463663:+GBMGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER8.3744e-030.3085image
ENSG00000128050.7,PAICSHNSCGSVA_HALLMARK_HEME_METABOLISMEAG7.3528e-10-0.2730image
chr4:56459892-56460985:+HNSCGSVA_HALLMARK_HEME_METABOLISMEER6.2300e-10-0.2744image
chr4:56459892-56460985:+KICHGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.7286e-03-0.3658image
ENSG00000128050.7,PAICSKICHGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.7286e-03-0.3658image
chr4:56459892-56460985:+KIRCGSVA_HALLMARK_PROTEIN_SECRETIONEER7.4283e-09-0.2896image
ENSG00000128050.7,PAICSKIRCGSVA_HALLMARK_PROTEIN_SECRETIONEAG7.6220e-09-0.2894image
ENSG00000128050.7,PAICSKIRPGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.5512e-04-0.2219image
chr4:56459892-56460985:+KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEER1.5536e-04-0.2218image
chr4:56459892-56460985:+LAMLGSVA_HALLMARK_PEROXISOMEEER3.9017e-04-0.2878image
ENSG00000128050.7,PAICSLAMLGSVA_HALLMARK_PEROXISOMEEAG6.6334e-04-0.2767image
chr4:56459892-56460985:+LGGGSVA_HALLMARK_G2M_CHECKPOINTEER4.2421e-18-0.3648image
ENSG00000128050.7,PAICSLGGGSVA_HALLMARK_G2M_CHECKPOINTEAG1.1265e-17-0.3605image
chr4:56459892-56460985:+LIHCGSVA_HALLMARK_SPERMATOGENESISEER8.8285e-05-0.2019image
ENSG00000128050.7,PAICSLIHCGSVA_HALLMARK_SPERMATOGENESISEAG6.4260e-05-0.2057image
chr4:56459892-56460985:+LUADGSVA_HALLMARK_KRAS_SIGNALING_DNEER6.2356e-06-0.1980image
ENSG00000128050.7,PAICSLUADGSVA_HALLMARK_KRAS_SIGNALING_DNEAG5.9267e-06-0.1985image
ENSG00000128050.7,PAICSLUSCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG6.4907e-07-0.2210image
chr4:56459892-56460985:+LUSCGSVA_HALLMARK_BILE_ACID_METABOLISMEER6.7234e-07-0.2209image
chr4:56459892-56460985:+MESOGSVA_HALLMARK_APICAL_JUNCTIONEER3.6890e-02-0.2323image
ENSG00000128050.7,PAICSMESOGSVA_HALLMARK_APICAL_JUNCTIONEAG3.7558e-02-0.2315image
ENSG00000128050.7,PAICSOVGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG6.2625e-06-0.2618image
chr4:56459892-56460985:+OVGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER5.6831e-06-0.2629image
chr4:56459892-56460985:+PAADGSVA_HALLMARK_SPERMATOGENESISEER6.7336e-05-0.2942image
ENSG00000128050.7,PAICSPAADGSVA_HALLMARK_SPERMATOGENESISEAG6.7988e-05-0.2940image
ENSG00000128050.7,PAICSPCPGGSVA_HALLMARK_KRAS_SIGNALING_DNEAG8.3161e-050.2867image
chr4:56459892-56460985:+PCPGGSVA_HALLMARK_KRAS_SIGNALING_DNEER8.2928e-050.2868image
ENSG00000128050.7,PAICSPRADGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.9737e-12-0.3084image
chr4:56459892-56460985:+PRADGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.8674e-12-0.3087image
ENSG00000128050.7,PAICSREADGSVA_HALLMARK_MYC_TARGETS_V2EAG3.1642e-03-0.2998image
chr4:56459892-56460985:+READGSVA_HALLMARK_MYC_TARGETS_V2EER9.6611e-04-0.3350image
ENSG00000128050.7,PAICSSARCGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG9.5713e-03-0.1623image
chr4:56459892-56460985:+SARCGSVA_HALLMARK_TGF_BETA_SIGNALINGEER1.0881e-02-0.1595image
chr4:56459892-56460985:+SKCMGSVA_HALLMARK_ANGIOGENESISEER2.1183e-05-0.1966image
ENSG00000128050.7,PAICSSKCMGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.4578e-04-0.1752image
ENSG00000128050.7,PAICSSTADGSVA_HALLMARK_KRAS_SIGNALING_DNEAG4.3669e-05-0.2102image
chr4:56459892-56460985:+STADGSVA_HALLMARK_KRAS_SIGNALING_DNEER5.8327e-05-0.2068image
chr4:56459892-56460985:+TGCTGSVA_HALLMARK_UV_RESPONSE_DNEER4.7296e-10-0.4766image
ENSG00000128050.7,PAICSTGCTGSVA_HALLMARK_UV_RESPONSE_DNEAG4.8839e-10-0.4763image
chr4:56459892-56460985:+THCAGSVA_HALLMARK_HEME_METABOLISMEER3.4716e-05-0.1837image
ENSG00000128050.7,PAICSTHCAGSVA_HALLMARK_DNA_REPAIREAG3.6850e-050.1831image
ENSG00000128050.7,PAICSTHYMGSVA_HALLMARK_E2F_TARGETSEAG3.5549e-13-0.6081image
chr4:56459892-56460985:+THYMGSVA_HALLMARK_E2F_TARGETSEER3.1946e-13-0.6090image
chr4:56459892-56460985:+UCECGSVA_HALLMARK_MITOTIC_SPINDLEEER1.9069e-05-0.3180image
ENSG00000128050.7,PAICSUCECGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.9219e-05-0.3103image
chr4:56459892-56460985:+UCSGSVA_HALLMARK_MYOGENESISEER3.4420e-03-0.3878image
ENSG00000128050.7,PAICSUCSGSVA_HALLMARK_MYOGENESISEAG3.4754e-03-0.3874image
chr4:56459892-56460985:+UVMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER2.9000e-020.2442image
ENSG00000128050.7,PAICSUVMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG2.9000e-020.2442image


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7. Enriched editing regions and drugs for PAICS


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr4:56459892-56460985:+ACCABT.263EER7.3808e-030.2993image
ENSG00000128050.7,PAICSACCABT.263EAG7.0788e-030.3007image
ENSG00000128050.7,PAICSBLCAAxitinibEAG6.3495e-050.1993image
chr4:56459892-56460985:+BLCAAxitinibEER4.6034e-050.2035image
chr4:56462702-56463663:+BRCABicalutamideEER2.6930e-02-0.2082image
chr4:56459892-56460985:+BRCABMS.708163EER2.2291e-100.1913image
ENSG00000128050.7,PAICSBRCABMS.708163EAG2.8725e-100.1902image
chr4:56459892-56460985:+CESCBMS.536924EER8.2285e-08-0.3055image
ENSG00000128050.7,PAICSCESCBMS.536924EAG4.4074e-08-0.3110image
ENSG00000128050.7,PAICSCHOLGSK269962AEAG8.3303e-030.4390image
chr4:56459892-56460985:+CHOLGSK269962AEER8.3303e-030.4390image
ENSG00000128050.7,PAICSCOADAZ628EAG5.1940e-04-0.2076image
chr4:56459892-56460985:+COADAZ628EER4.8939e-04-0.2085image
chr4:56459892-56460985:+DLBCA.443654EER4.6284e-020.3021image
ENSG00000128050.7,PAICSDLBCA.443654EAG4.6280e-020.3021image
chr4:56462702-56463663:+ESCABIRB.0796EER9.2329e-040.5036image
chr4:56459892-56460985:+ESCAAMG.706EER1.2419e-02-0.1979image
ENSG00000128050.7,PAICSESCAAMG.706EAG1.3145e-02-0.1963image
ENSG00000128050.7,PAICSGBMCytarabineEAG8.0233e-070.3709image
chr4:56462702-56463663:+GBMCI.1040EER2.7051e-03-0.3484image
chr4:56459892-56460985:+GBMCytarabineEER6.3891e-070.3740image
chr4:56459892-56460985:+HNSCA.770041EER7.4903e-07-0.2213image
ENSG00000128050.7,PAICSHNSCA.770041EAG6.9146e-07-0.2218image
chr4:56459892-56460985:+KICHDasatinibEER2.5127e-020.2798image
ENSG00000128050.7,PAICSKICHDasatinibEAG2.5127e-020.2798image
chr4:56459892-56460985:+KIRCBMS.536924EER6.0518e-09-0.2920image
ENSG00000128050.7,PAICSKIRCBMS.536924EAG6.1207e-09-0.2919image
chr4:56459892-56460985:+KIRPAZD6482EER1.2888e-060.2817image
ENSG00000128050.7,PAICSKIRPAZD6482EAG1.2746e-060.2818image
ENSG00000128050.7,PAICSLAMLEHT.1864EAG2.0669e-030.2513image
chr4:56459892-56460985:+LAMLEHT.1864EER2.2659e-030.2491image
chr4:56459892-56460985:+LGGCytarabineEER3.6934e-130.3089image
ENSG00000128050.7,PAICSLGGCytarabineEAG5.8943e-130.3063image
chr4:56459892-56460985:+LIHCBMS.754807EER3.2212e-060.2394image
ENSG00000128050.7,PAICSLIHCBMS.754807EAG9.5223e-060.2279image
chr4:56459892-56460985:+LUADGemcitabineEER4.5969e-04-0.1541image
ENSG00000128050.7,PAICSLUADGemcitabineEAG4.5275e-04-0.1543image
ENSG00000128050.7,PAICSLUSCAP.24534EAG3.3588e-040.1602image
chr4:56459892-56460985:+LUSCAP.24534EER3.5937e-040.1596image
chr4:56459892-56460985:+MESOAICAREER1.1410e-030.3551image
ENSG00000128050.7,PAICSMESOAICAREAG1.1773e-030.3542image
chr4:56462702-56463663:+OVAKT.inhibitor.VIIIEER1.2262e-040.4651image
ENSG00000128050.7,PAICSOVBexaroteneEAG2.5253e-060.2723image
chr4:56459892-56460985:+OVBexaroteneEER2.7576e-060.2713image
chr4:56459892-56460985:+PAADAZD6482EER4.3801e-060.3430image
ENSG00000128050.7,PAICSPAADAZD6482EAG4.4150e-060.3429image
chr4:56459892-56460985:+PCPGEpothilone.BEER8.4604e-070.3546image
ENSG00000128050.7,PAICSPCPGEpothilone.BEAG8.3514e-070.3547image
ENSG00000128050.7,PAICSPRADAZD.2281EAG3.9077e-18-0.3763image
chr4:56459892-56460985:+PRADAZD.2281EER4.6592e-18-0.3755image
ENSG00000128050.7,PAICSREADCyclopamineEAG3.2442e-03-0.3006image
chr4:56459892-56460985:+READCyclopamineEER1.1905e-03-0.3310image
chr4:56459892-56460985:+SARCCMKEER2.0306e-060.2929image
ENSG00000128050.7,PAICSSARCCMKEAG1.2265e-060.2989image
chr4:56459892-56460985:+SKCMAZD6244EER1.7827e-06-0.2203image
ENSG00000128050.7,PAICSSKCMABT.263EAG2.4592e-050.1945image
chr4:56462702-56463663:+STADAG.014699EER1.6604e-02-0.3634image
ENSG00000128050.7,PAICSSTADBIBW2992EAG4.3847e-04-0.1831image
chr4:56459892-56460985:+STADCamptothecinEER4.4517e-04-0.1812image
chr4:56459892-56460985:+TGCTGefitinibEER4.5719e-09-0.4518image
ENSG00000128050.7,PAICSTGCTGefitinibEAG5.4985e-09-0.4497image
chr4:56459892-56460985:+THCAAZD6482EER5.0316e-150.3397image
ENSG00000128050.7,PAICSTHCAAZD6482EAG5.2938e-150.3394image
ENSG00000128050.7,PAICSTHYMIPA.3EAG1.4502e-170.6858image
chr4:56459892-56460985:+THYMIPA.3EER1.1726e-170.6872image
chr4:56459892-56460985:+UCECImatinibEER1.5603e-100.4609image
ENSG00000128050.7,PAICSUCECImatinibEAG1.2894e-100.4615image
ENSG00000128050.7,PAICSUCSA.443654EAG8.3142e-04-0.4377image
chr4:56459892-56460985:+UCSA.443654EER9.2256e-04-0.4343image
chr4:56459892-56460985:+UVMFH535EER2.1490e-020.2568image
ENSG00000128050.7,PAICSUVMFH535EAG2.1490e-020.2568image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType
chr4:56459892-56460985:+ENST00000264221.5P22234DB00128Aspartic acidSmallMoleculeDrug
chr4:56459892-56460985:+ENST00000399688.6P22234DB00128Aspartic acidSmallMoleculeDrug
chr4:56459892-56460985:+ENST00000512576.2P22234DB00128Aspartic acidSmallMoleculeDrug
chr4:56462702-56463663:+ENST00000512576.2P22234DB00128Aspartic acidSmallMoleculeDrug