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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: CENPC (ImmuneEditome ID:1060)

1. Gene summary of enriched editing regions for CENPC

check button Gene summary
Gene informationGene symbol

CENPC

Gene ID

1060

GeneSynonymsCENP-C|CENPC1|MIF2|hcp-4
GeneCytomap

4q13.2

GeneTypeprotein-coding
GeneDescriptioncentromere protein C|CENP-C 1|centromere autoantigen C|centromere autoantigen C1|centromere protein C 1|interphase centromere complex protein 7
GeneModificationdate20230404
UniprotIDQ03188;H0Y8J2;H0Y9W1
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr4:67469328-67470608:-ENST00000273853.9ENSG00000145241.9CENPCUTR3AluSq2,L1MEc,AluSx1,L1PBb,MER3chr4:67469328-67470608:-.alignment


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2. Tumor-specific enriched editing regions for CENPC


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr4:67469328-67470608:-BRCAEER9.4173e-09image
ENSG00000145241.9,CENPCBRCAEAG3.7378e-08image
chr4:67469328-67470608:-KIRCEER9.8529e-04image
ENSG00000145241.9,CENPCKIRCEAG2.4385e-03image
chr4:67469328-67470608:-KIRPEER5.9602e-03image
ENSG00000145241.9,CENPCKIRPEAG5.5787e-03image
chr4:67469328-67470608:-PRADEER3.0509e-02image
ENSG00000145241.9,CENPCPRADEAG3.1457e-02image
chr4:67469328-67470608:-THCAEER1.2789e-04image
ENSG00000145241.9,CENPCTHCAEAG1.5459e-04image
chr4:67469328-67470608:-UCECEER1.1015e-02image
ENSG00000145241.9,CENPCUCECEAG7.4148e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr4:67469328-67470608:-ACCPathEER1.8937e-021.6861e-02-0.3507image
ENSG00000145241.9,CENPCACCPathEAG1.8937e-021.6861e-02-0.3507image
ENSG00000145241.9,CENPCTGCTCliEAG1.4922e-021.0587e-02-0.4048image
chr4:67469328-67470608:-TGCTCliEER1.4922e-021.0587e-02-0.4048image
chr4:67469328-67470608:-THCAPathEER6.7502e-043.0554e-040.1657image
ENSG00000145241.9,CENPCTHCAPathEAG5.7458e-042.2744e-040.1689image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr4:67469328-67470608:-KIRPEER6.9892e-031.1297e-021.2204e+02image
ENSG00000145241.9,CENPCKIRPEAG6.9892e-031.1297e-021.2204e+02image

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3. Enriched editing regions and immune related genes for CENPC


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr4:67469328-67470608:-THCAEERENSG00000273015,RP11-352M15.2-0.39851.0944e-161.0220e-22-0.4301imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr4:67469328-67470608:-THCAEERENSG00000138316,ADAMTS140.37131.2559e-145.2611e-200.4041imageNNNADendritic_cells_restingGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr4:67469328-67470608:-THCAEERENSG00000176422,SPRYD4-0.37241.7211e-141.1438e-19-0.4007imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr4:67469328-67470608:-THCAEERENSG00000153896,ZNF599-0.37222.3709e-141.0137e-19-0.4012imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr4:67469328-67470608:-THCAEERENSG00000182718,ANXA20.36325.0577e-142.2073e-200.4078imageNNANXA2Dendritic_cells_restingGSVA_HALLMARK_P53_PATHWAY
chr4:67469328-67470608:-THCAEERENSG00000115414,FN10.35581.3609e-136.6030e-210.4130imageNNFN1Dendritic_cells_restingGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr4:67469328-67470608:-THCAEERENSG00000147654,EBAG9-0.35322.1141e-131.5404e-20-0.4094imageNNEBAG9T_cells_regulatory_(Tregs)GSVA_HALLMARK_APICAL_JUNCTION
chr4:67469328-67470608:-THCAEERENSG00000197747,S100A100.35195.0379e-131.2985e-190.4001imageNNS100A10Dendritic_cells_restingGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr4:67469328-67470608:-THCAEERENSG00000132965,ALOX5AP0.34921.2903e-121.3123e-190.4001imageNNALOX5APT_cells_CD4_memory_activatedGSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr4:67469328-67470608:-THCAEERENSG00000121552,CSTA0.34971.5272e-121.1630e-190.4006imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION

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4. Enriched editing regions and immune related splicing for CENPC


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr4:67469328-67470608:-
THYMEERA5ENSG00000178209.10chr8143921931:143922395:143926783:143926882:143922503:143926882-0.35501.4056e-027.4720e-05-0.4138imageNNPLECT_cells_regulatory_(Tregs)GSVA_HALLMARK_P53_PATHWAY
ENSG00000145241.9,CENPC
THYMEAGA5ENSG00000138768.10chr475799621:75799732:75793689:75793901:75793689:75795356-0.31743.6790e-021.5446e-05-0.4551imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAMast_cells_restingGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000145241.9,CENPC
THYMEAGA3ENSG00000099953.5chr2223781263:23781409:23782225:23782315:23781787:237823150.34141.0281e-021.2238e-040.4003imageNADAR;AUH;BCCIP;BUD13;CSTF2T;DGCR8;DKC1;EIF4A3;ELAVL1;FAM120A;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;LIN28;LIN28B;PCBP2;PRPF8;RBFOX2;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1;ZNF184NAMacrophages_M1GSVA_HALLMARK_ANGIOGENESIS
chr4:67469328-67470608:-
THYMEERA3ENSG00000165238.12chr993299114:93299261:93306776:93306821:93300050:93306821-0.43224.0674e-035.1546e-06-0.4443imageNNWNK2T_cells_CD4_memory_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr4:67469328-67470608:-
THYMEERMEXENSG00000196776.10chr3108047080:108047292:108050577:108051752:108051938:108054215:108057476:1080575330.37712.4190e-021.9654e-060.4593imageNNCD47Dendritic_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000145241.9,CENPC
THYMEAGMEXENSG00000196776.10chr3108047080:108047292:108050577:108051752:108051938:108054215:108057476:1080575330.37712.5999e-021.9654e-060.4593imageNACIN1;ADAR;AIFM1;ALYREF;AUH;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZNF184CD47Dendritic_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr4:67469328-67470608:-
THYMEERIRENSG00000102890.10chr1667202626:67203004:67203118:67203223-0.40548.5448e-033.4909e-05-0.4072imageNNELMO3T_cells_CD4_naiveGSVA_HALLMARK_E2F_TARGETS
ENSG00000145241.9,CENPC
THYMEAGMEXENSG00000165238.12chr993299114:93299261:93300050:93300153:93306776:93307195:93308327:933085840.40491.0754e-023.5582e-050.4068imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS3;LARP4B;LARP7;LIN28;LIN28B;MBNL2;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;YTHDC1;YTHDF1;ZNF184WNK2T_cells_CD4_memory_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr4:67469328-67470608:-
THYMEERESENSG00000092199.13chr1421234218:21234229:21262600:21263336:21269297:21269389-0.39891.2040e-023.6315e-05-0.4044imageNNNAMacrophages_M0GSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr4:67469328-67470608:-
THYMEERMEXENSG00000026508.12chr1135180357:35180407:35189834:35190065:35208136:35208206:35214851:35214861-0.35018.1517e-031.5113e-05-0.4219imageNNCD44NK_cells_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE

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5. Enriched editing regions and immune infiltration for CENPC


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr4:67469328-67470608:-ACCEERMacrophages_M11.8795e-03-0.4418image
ENSG00000145241.9,CENPCACCEAGMacrophages_M11.8795e-03-0.4418image
chr4:67469328-67470608:-BLCAEERT_cells_CD87.0372e-030.2568image
ENSG00000145241.9,CENPCBLCAEAGT_cells_regulatory_(Tregs)1.2521e-02-0.2363image
chr4:67469328-67470608:-BRCAEERMonocytes2.9851e-03-0.1074image
ENSG00000145241.9,CENPCBRCAEAGMonocytes5.1197e-03-0.1010image
chr4:67469328-67470608:-CESCEERT_cells_CD4_memory_activated3.3377e-020.1657image
ENSG00000145241.9,CENPCCESCEAGT_cells_CD4_memory_activated3.9088e-020.1603image
chr4:67469328-67470608:-COADEERT_cells_follicular_helper6.7146e-040.5336image
ENSG00000145241.9,CENPCCOADEAGEosinophils1.6891e-040.5668image
chr4:67469328-67470608:-ESCAEERNeutrophils7.6259e-030.3000image
ENSG00000145241.9,CENPCESCAEAGNeutrophils4.7159e-030.3129image
chr4:67469328-67470608:-GBMEERT_cells_gamma_delta4.9621e-020.2912image
ENSG00000145241.9,CENPCGBMEAGT_cells_gamma_delta4.0037e-020.3006image
chr4:67469328-67470608:-HNSCEERMacrophages_M22.1994e-020.2774image
ENSG00000145241.9,CENPCHNSCEAGMacrophages_M21.8196e-020.2836image
chr4:67469328-67470608:-KICHEERMonocytes4.5918e-020.2781image
ENSG00000145241.9,CENPCKICHEAGMonocytes4.5918e-020.2781image
chr4:67469328-67470608:-KIRCEERMast_cells_resting2.3101e-02-0.1390image
ENSG00000145241.9,CENPCKIRCEAGNK_cells_activated4.2410e-02-0.1236image
chr4:67469328-67470608:-KIRPEERT_cells_CD4_memory_resting2.1006e-02-0.2015image
ENSG00000145241.9,CENPCKIRPEAGT_cells_CD4_memory_resting2.4625e-02-0.1956image
ENSG00000145241.9,CENPCLAMLEAGMacrophages_M09.4998e-030.2720image
chr4:67469328-67470608:-LGGEERNeutrophils3.7757e-030.1859image
ENSG00000145241.9,CENPCLGGEAGNeutrophils3.7757e-030.1859image
chr4:67469328-67470608:-LUADEERMonocytes4.1641e-02-0.1706image
ENSG00000145241.9,CENPCLUADEAGMonocytes4.9287e-02-0.1642image
chr4:67469328-67470608:-MESOEERMacrophages_M09.3902e-03-0.3873image
ENSG00000145241.9,CENPCMESOEAGMacrophages_M01.9203e-02-0.3479image
chr4:67469328-67470608:-OVEERNK_cells_resting1.6397e-02-0.1687image
ENSG00000145241.9,CENPCOVEAGNK_cells_resting1.6397e-02-0.1687image
chr4:67469328-67470608:-PAADEERMonocytes1.9308e-020.2771image
ENSG00000145241.9,CENPCPAADEAGMonocytes1.4867e-020.2860image
chr4:67469328-67470608:-PCPGEERT_cells_CD4_memory_resting1.0848e-02-0.2068image
ENSG00000145241.9,CENPCPCPGEAGT_cells_CD4_memory_resting1.0848e-02-0.2068image
chr4:67469328-67470608:-PRADEERMacrophages_M13.6862e-030.1475image
ENSG00000145241.9,CENPCPRADEAGMacrophages_M13.7144e-030.1474image
chr4:67469328-67470608:-SARCEERMacrophages_M18.5112e-030.2134image
ENSG00000145241.9,CENPCSARCEAGB_cells_naive8.8020e-03-0.2118image
chr4:67469328-67470608:-SKCMEERMacrophages_M02.4373e-03-0.2351image
ENSG00000145241.9,CENPCSKCMEAGMacrophages_M02.3929e-03-0.2349image
chr4:67469328-67470608:-STADEERT_cells_CD4_naive3.0825e-02-0.1638image
chr4:67469328-67470608:-THCAEERT_cells_CD4_memory_activated6.8306e-060.2052image
ENSG00000145241.9,CENPCTHCAEAGT_cells_CD4_memory_activated6.4015e-060.2056image
chr4:67469328-67470608:-THYMEERT_cells_gamma_delta4.0026e-040.3507image
ENSG00000145241.9,CENPCTHYMEAGT_cells_gamma_delta4.0026e-040.3507image
chr4:67469328-67470608:-UVMEERT_cells_regulatory_(Tregs)1.0717e-020.4746image
ENSG00000145241.9,CENPCUVMEAGT_cells_regulatory_(Tregs)1.0717e-020.4746image


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6. Enriched editing regions and immune gene sets for CENPC


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr4:67469328-67470608:-THCAEER3.3537e-03image7.1334e-160.3595image
ENSG00000145241.9,CENPCTHCAEAG3.0050e-03image2.3569e-160.3647image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr4:67469328-67470608:-ACCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER3.7081e-020.3050image
ENSG00000145241.9,CENPCACCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG3.7081e-020.3050image
chr4:67469328-67470608:-BLCAGSVA_HALLMARK_E2F_TARGETSEER4.0521e-020.1966image
ENSG00000145241.9,CENPCBRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.6755e-070.1876image
chr4:67469328-67470608:-BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.4487e-080.2002image
chr4:67469328-67470608:-CESCGSVA_HALLMARK_MITOTIC_SPINDLEEER1.7388e-03-0.2420image
ENSG00000145241.9,CENPCCESCGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.7539e-03-0.2238image
ENSG00000145241.9,CENPCCOADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG7.0713e-030.4245image
chr4:67469328-67470608:-COADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER2.3376e-040.5696image
chr4:67469328-67470608:-ESCAGSVA_HALLMARK_ADIPOGENESISEER2.4391e-030.3384image
ENSG00000145241.9,CENPCESCAGSVA_HALLMARK_ADIPOGENESISEAG9.4600e-040.3627image
ENSG00000145241.9,CENPCGBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.3599e-020.3576image
chr4:67469328-67470608:-GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.5798e-020.3285image
ENSG00000145241.9,CENPCHNSCGSVA_HALLMARK_COMPLEMENTEAG2.1739e-030.3630image
chr4:67469328-67470608:-HNSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.2592e-030.3832image
ENSG00000145241.9,CENPCKICHGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.6352e-020.3315image
chr4:67469328-67470608:-KICHGSVA_HALLMARK_NOTCH_SIGNALINGEER1.6352e-020.3315image
chr4:67469328-67470608:-KIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.5492e-020.2111image
ENSG00000145241.9,CENPCKIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.9244e-020.1898image
ENSG00000145241.9,CENPCLAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.1969e-02-0.2639image
chr4:67469328-67470608:-LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEER3.0937e-02-0.2766image
chr4:67469328-67470608:-LGGGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.9700e-020.1401image
ENSG00000145241.9,CENPCLGGGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.9700e-020.1401image
ENSG00000145241.9,CENPCLUADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG1.6284e-020.1999image
chr4:67469328-67470608:-LUADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER2.8219e-020.1835image
chr4:67469328-67470608:-LUSCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.5087e-020.2205image
ENSG00000145241.9,CENPCLUSCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG7.6962e-030.2392image
chr4:67469328-67470608:-OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.8887e-030.1931image
ENSG00000145241.9,CENPCOVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.8887e-030.1931image
ENSG00000145241.9,CENPCPAADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG2.3543e-020.2667image
chr4:67469328-67470608:-PAADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER3.2145e-020.2546image
chr4:67469328-67470608:-PCPGGSVA_HALLMARK_MYC_TARGETS_V1EER1.4720e-02-0.1982image
ENSG00000145241.9,CENPCPCPGGSVA_HALLMARK_MYC_TARGETS_V1EAG1.4720e-02-0.1982image
ENSG00000145241.9,CENPCPRADGSVA_HALLMARK_E2F_TARGETSEAG1.8020e-030.1584image
chr4:67469328-67470608:-PRADGSVA_HALLMARK_E2F_TARGETSEER1.7428e-030.1589image
ENSG00000145241.9,CENPCSARCGSVA_HALLMARK_IL2_STAT5_SIGNALINGEAG4.1047e-040.2830image
chr4:67469328-67470608:-SARCGSVA_HALLMARK_IL2_STAT5_SIGNALINGEER1.6993e-030.2533image
ENSG00000145241.9,CENPCSKCMGSVA_HALLMARK_GLYCOLYSISEAG3.2454e-03-0.2279image
chr4:67469328-67470608:-SKCMGSVA_HALLMARK_GLYCOLYSISEER2.0362e-03-0.2392image
ENSG00000145241.9,CENPCSTADGSVA_HALLMARK_NOTCH_SIGNALINGEAG7.8617e-030.1970image
chr4:67469328-67470608:-STADGSVA_HALLMARK_APICAL_SURFACEEER6.1288e-030.2070image
ENSG00000145241.9,CENPCTGCTGSVA_HALLMARK_GLYCOLYSISEAG1.2741e-02-0.2791image
chr4:67469328-67470608:-TGCTGSVA_HALLMARK_GLYCOLYSISEER1.2741e-02-0.2791image
chr4:67469328-67470608:-THCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER7.5992e-180.3816image
ENSG00000145241.9,CENPCTHCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG2.6075e-180.3862image
chr4:67469328-67470608:-THYMGSVA_HALLMARK_MITOTIC_SPINDLEEER4.0345e-04-0.3505image
ENSG00000145241.9,CENPCTHYMGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.0345e-04-0.3505image
ENSG00000145241.9,CENPCUCECGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.2905e-02-0.2650image
chr4:67469328-67470608:-UCECGSVA_HALLMARK_MYC_TARGETS_V2EER4.9916e-020.2462image
chr4:67469328-67470608:-UCSGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.4379e-020.4930image
ENSG00000145241.9,CENPCUCSGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.4379e-020.4930image
ENSG00000145241.9,CENPCUVMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.1568e-020.4702image
chr4:67469328-67470608:-UVMGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.1568e-020.4702image


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7. Enriched editing regions and drugs for CENPC


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr4:67469328-67470608:-ACCAP.24534EER2.6948e-030.4279image
ENSG00000145241.9,CENPCACCAP.24534EAG2.6948e-030.4279image
ENSG00000145241.9,CENPCBLCALFM.A13EAG1.6769e-020.2266image
chr4:67469328-67470608:-BLCALFM.A13EER1.3037e-020.2371image
chr4:67469328-67470608:-BRCAAxitinibEER2.9730e-030.1075image
ENSG00000145241.9,CENPCBRCAAxitinibEAG3.1543e-030.1065image
ENSG00000145241.9,CENPCCESCCEP.701EAG1.9435e-05-0.3249image
chr4:67469328-67470608:-CESCCEP.701EER2.9402e-05-0.3191image
ENSG00000145241.9,CENPCCOADImatinibEAG1.2361e-02-0.3969image
chr4:67469328-67470608:-COADAZD8055EER3.6310e-03-0.4662image
ENSG00000145241.9,CENPCESCAJNJ.26854165EAG1.1709e-040.4174image
chr4:67469328-67470608:-ESCABleomycinEER2.3885e-040.4046image
ENSG00000145241.9,CENPCGBMAS601245EAG3.0615e-03-0.4229image
chr4:67469328-67470608:-GBMAS601245EER7.0177e-03-0.3922image
ENSG00000145241.9,CENPCHNSCAP.24534EAG4.4696e-04-0.4113image
chr4:67469328-67470608:-HNSCAP.24534EER7.0066e-04-0.4010image
ENSG00000145241.9,CENPCKICHAMG.706EAG7.6408e-030.3659image
chr4:67469328-67470608:-KICHAMG.706EER7.6408e-030.3659image
ENSG00000145241.9,CENPCKIRCAZD6244EAG9.9951e-04-0.1992image
chr4:67469328-67470608:-KIRCAZD6244EER2.5342e-03-0.1841image
chr4:67469328-67470608:-KIRPEHT.1864EER1.5720e-020.2107image
ENSG00000145241.9,CENPCKIRPGW.441756EAG1.3564e-02-0.2144image
ENSG00000145241.9,CENPCLAMLCMKEAG1.3994e-03-0.3318image
chr4:67469328-67470608:-LAMLAZD6482EER1.0981e-02-0.3235image
ENSG00000145241.9,CENPCLGGBMS.708163EAG2.2600e-02-0.1468image
chr4:67469328-67470608:-LGGBMS.708163EER2.2600e-02-0.1468image
chr4:67469328-67470608:-LUSCErlotinibEER1.7237e-020.2162image
ENSG00000145241.9,CENPCLUSCErlotinibEAG1.4041e-020.2210image
chr4:67469328-67470608:-MESOCHIR.99021EER5.6944e-03-0.4101image
ENSG00000145241.9,CENPCMESOCHIR.99021EAG1.1986e-02-0.3715image
chr4:67469328-67470608:-OVBMS.509744EER1.0424e-03-0.2290image
ENSG00000145241.9,CENPCOVBMS.509744EAG1.0424e-03-0.2290image
chr4:67469328-67470608:-PAADATRAEER1.3725e-020.2954image
ENSG00000145241.9,CENPCPAADATRAEAG5.4673e-030.3287image
chr4:67469328-67470608:-PCPGBIRB.0796EER1.0682e-020.2072image
ENSG00000145241.9,CENPCPCPGBIRB.0796EAG1.0682e-020.2072image
ENSG00000145241.9,CENPCPRADBMS.754807EAG1.2881e-040.1937image
chr4:67469328-67470608:-PRADBMS.754807EER1.3104e-040.1934image
ENSG00000145241.9,CENPCSARCBortezomibEAG9.1141e-05-0.3120image
chr4:67469328-67470608:-SARCEHT.1864EER1.2231e-030.2607image
ENSG00000145241.9,CENPCSKCMABT.888EAG3.0909e-04-0.2774image
chr4:67469328-67470608:-SKCMABT.888EER1.0883e-04-0.2976image
chr4:67469328-67470608:-STADBexaroteneEER1.9518e-02-0.1769image
ENSG00000145241.9,CENPCTGCTAICAREAG1.7550e-02-0.2666image
chr4:67469328-67470608:-TGCTAICAREER1.7550e-02-0.2666image
chr4:67469328-67470608:-THCACI.1040EER8.1853e-21-0.4121image
ENSG00000145241.9,CENPCTHCACI.1040EAG1.9665e-19-0.3979image
chr4:67469328-67470608:-THYMGDC0941EER6.6435e-070.4775image
ENSG00000145241.9,CENPCTHYMGDC0941EAG6.6435e-070.4775image
ENSG00000145241.9,CENPCUCECAZD.0530EAG4.4305e-03-0.3486image
chr4:67469328-67470608:-UCECCGP.082996EER5.9382e-03-0.3403image
chr4:67469328-67470608:-UCSCMKEER1.9653e-020.4728image
ENSG00000145241.9,CENPCUCSCMKEAG1.9653e-020.4728image
chr4:67469328-67470608:-UVMBX.795EER2.7943e-02-0.4154image
ENSG00000145241.9,CENPCUVMBX.795EAG2.7943e-02-0.4154image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType