CAeditome Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: SAPCD1-AS1 (ImmuneEditome ID:104413891)

1. Gene summary of enriched editing regions for SAPCD1-AS1

check button Gene summary
Gene informationGene symbol

SAPCD1-AS1

Gene ID

104413891

GeneSynonymsC6orf26-AS1
GeneCytomap

6p21.33

GeneTypencRNA
GeneDescriptionC6orf26 antisense RNA 1 (non-protein coding)|SAPCD1 antisense RNA 1 (non-protein coding)|XXbac-BPG32J3.18
GeneModificationdate20230329
UniprotID.
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr6:31764941-31765442:-ENST00000419679.1ENSG00000235663.1SAPCD1-AS1ncRNA_intronicAluJb,AluSqchr6:31764941-31765442:-.alignment


Top

2. Tumor-specific enriched editing regions for SAPCD1-AS1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr6:31764941-31765442:-THCAEER1.8199e-02image
ENSG00000235663.1,SAPCD1-AS1THCAEAG1.8199e-02image
chr6:31764941-31765442:-UCECEER6.1881e-03image
ENSG00000235663.1,SAPCD1-AS1UCECEAG6.1881e-03image


Top

check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr6:31764941-31765442:-KIRPPathEER2.5929e-022.2022e-02-0.1475image
ENSG00000235663.1,SAPCD1-AS1KIRPPathEAG2.5929e-022.2022e-02-0.1475image


Top

check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

Top

3. Enriched editing regions and immune related genes for SAPCD1-AS1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



Top

4. Enriched editing regions and immune related splicing for SAPCD1-AS1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



Top

5. Enriched editing regions and immune infiltration for SAPCD1-AS1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr6:31764941-31765442:-CESCEERNK_cells_resting6.3478e-030.3027image
ENSG00000235663.1,SAPCD1-AS1CESCEAGNK_cells_resting6.3478e-030.3027image
chr6:31764941-31765442:-CHOLEERT_cells_regulatory_(Tregs)6.3031e-030.4798image
ENSG00000235663.1,SAPCD1-AS1CHOLEAGT_cells_regulatory_(Tregs)6.3031e-030.4798image
ENSG00000235663.1,SAPCD1-AS1COADEAGEosinophils4.1310e-060.4639image
chr6:31764941-31765442:-ESCAEERMonocytes4.8194e-020.2162image
ENSG00000235663.1,SAPCD1-AS1ESCAEAGMonocytes4.8194e-020.2162image
chr6:31764941-31765442:-HNSCEERT_cells_CD82.4804e-02-0.3637image
ENSG00000235663.1,SAPCD1-AS1HNSCEAGT_cells_CD82.4804e-02-0.3637image
chr6:31764941-31765442:-KICHEERT_cells_follicular_helper5.4778e-030.4118image
ENSG00000235663.1,SAPCD1-AS1KICHEAGT_cells_follicular_helper5.4778e-030.4118image
chr6:31764941-31765442:-KIRPEERNK_cells_activated7.3795e-030.1633image
ENSG00000235663.1,SAPCD1-AS1KIRPEAGNK_cells_activated7.3795e-030.1633image
chr6:31764941-31765442:-LGGEERT_cells_follicular_helper1.4965e-020.2516image
ENSG00000235663.1,SAPCD1-AS1LGGEAGT_cells_follicular_helper1.4965e-020.2516image
chr6:31764941-31765442:-LUADEEREosinophils3.6693e-02-0.1108image
ENSG00000235663.1,SAPCD1-AS1LUADEAGEosinophils3.6693e-02-0.1108image
chr6:31764941-31765442:-PAADEERDendritic_cells_resting1.7397e-030.2614image
ENSG00000235663.1,SAPCD1-AS1PAADEAGDendritic_cells_resting1.7397e-030.2614image
ENSG00000235663.1,SAPCD1-AS1READEAGNK_cells_resting1.5847e-030.4437image
chr6:31764941-31765442:-SARCEERNK_cells_activated4.1924e-020.3274image
ENSG00000235663.1,SAPCD1-AS1SARCEAGNK_cells_activated4.1924e-020.3274image
chr6:31764941-31765442:-STADEERT_cells_CD4_naive1.6051e-02-0.1537image
ENSG00000235663.1,SAPCD1-AS1STADEAGT_cells_CD4_naive1.5610e-02-0.1543image
chr6:31764941-31765442:-THCAEERMonocytes1.9446e-020.1070image
ENSG00000235663.1,SAPCD1-AS1THCAEAGMonocytes1.9446e-020.1070image
chr6:31764941-31765442:-THYMEERDendritic_cells_activated1.0787e-020.3412image
ENSG00000235663.1,SAPCD1-AS1THYMEAGDendritic_cells_activated1.0787e-020.3412image


Top

6. Enriched editing regions and immune gene sets for SAPCD1-AS1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


Top

check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


Top

check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr6:31764941-31765442:-BRCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER1.0907e-02-0.1456image
ENSG00000235663.1,SAPCD1-AS1BRCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.0907e-02-0.1456image
ENSG00000235663.1,SAPCD1-AS1CESCGSVA_HALLMARK_APOPTOSISEAG2.9712e-020.2432image
chr6:31764941-31765442:-CESCGSVA_HALLMARK_APOPTOSISEER2.9712e-020.2432image
ENSG00000235663.1,SAPCD1-AS1CHOLGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.2359e-03-0.5120image
chr6:31764941-31765442:-CHOLGSVA_HALLMARK_MITOTIC_SPINDLEEER3.2359e-03-0.5120image
ENSG00000235663.1,SAPCD1-AS1COADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG2.3761e-04-0.3782image
chr6:31764941-31765442:-GBMGSVA_HALLMARK_NOTCH_SIGNALINGEER2.1267e-02-0.4674image
ENSG00000235663.1,SAPCD1-AS1GBMGSVA_HALLMARK_NOTCH_SIGNALINGEAG2.1267e-02-0.4674image
ENSG00000235663.1,SAPCD1-AS1HNSCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG3.3491e-02-0.3457image
chr6:31764941-31765442:-HNSCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER3.3491e-02-0.3457image
ENSG00000235663.1,SAPCD1-AS1KICHGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG3.3112e-020.3219image
chr6:31764941-31765442:-KICHGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER3.3112e-020.3219image
ENSG00000235663.1,SAPCD1-AS1KIRCGSVA_HALLMARK_SPERMATOGENESISEAG1.8813e-02-0.1406image
chr6:31764941-31765442:-KIRCGSVA_HALLMARK_SPERMATOGENESISEER1.8813e-02-0.1406image
ENSG00000235663.1,SAPCD1-AS1KIRPGSVA_HALLMARK_MTORC1_SIGNALINGEAG4.2961e-05-0.2472image
chr6:31764941-31765442:-KIRPGSVA_HALLMARK_MTORC1_SIGNALINGEER4.2961e-05-0.2472image
chr6:31764941-31765442:-LGGGSVA_HALLMARK_ANDROGEN_RESPONSEEER2.2512e-04-0.3736image
ENSG00000235663.1,SAPCD1-AS1LGGGSVA_HALLMARK_ANDROGEN_RESPONSEEAG2.2512e-04-0.3736image
ENSG00000235663.1,SAPCD1-AS1LIHCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.9731e-020.1673image
chr6:31764941-31765442:-LIHCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.9731e-020.1673image
ENSG00000235663.1,SAPCD1-AS1LUSCGSVA_HALLMARK_NOTCH_SIGNALINGEAG3.5882e-03-0.2527image
chr6:31764941-31765442:-LUSCGSVA_HALLMARK_NOTCH_SIGNALINGEER3.5882e-03-0.2527image
chr6:31764941-31765442:-OVGSVA_HALLMARK_GLYCOLYSISEER8.7202e-040.2171image
ENSG00000235663.1,SAPCD1-AS1OVGSVA_HALLMARK_GLYCOLYSISEAG9.2875e-040.2160image
chr6:31764941-31765442:-PCPGGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER2.4179e-03-0.2319image
ENSG00000235663.1,SAPCD1-AS1PCPGGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG2.4179e-03-0.2319image
chr6:31764941-31765442:-PRADGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER1.5522e-02-0.3014image
ENSG00000235663.1,SAPCD1-AS1PRADGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG1.5522e-02-0.3014image
ENSG00000235663.1,SAPCD1-AS1READGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG3.9056e-03-0.4089image
chr6:31764941-31765442:-SARCGSVA_HALLMARK_ANGIOGENESISEER2.4452e-020.3598image
ENSG00000235663.1,SAPCD1-AS1SARCGSVA_HALLMARK_ANGIOGENESISEAG2.4452e-020.3598image


Top

7. Enriched editing regions and drugs for SAPCD1-AS1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr6:31764941-31765442:-BRCABryostatin.1EER1.4124e-03-0.1820image
ENSG00000235663.1,SAPCD1-AS1BRCABryostatin.1EAG1.4124e-03-0.1820image
chr6:31764941-31765442:-CESCGW.441756EER7.7567e-030.2956image
ENSG00000235663.1,SAPCD1-AS1CESCGW.441756EAG7.7567e-030.2956image
ENSG00000235663.1,SAPCD1-AS1CHOLMidostaurinEAG6.1080e-060.7153image
chr6:31764941-31765442:-CHOLMidostaurinEER6.1080e-060.7153image
ENSG00000235663.1,SAPCD1-AS1COADAG.014699EAG7.3135e-04-0.3496image
ENSG00000235663.1,SAPCD1-AS1ESCAMethotrexateEAG2.7632e-04-0.3870image
chr6:31764941-31765442:-ESCAMethotrexateEER2.7632e-04-0.3870image
ENSG00000235663.1,SAPCD1-AS1GBMBMS.754807EAG1.1586e-02-0.5063image
chr6:31764941-31765442:-GBMBMS.754807EER1.1586e-02-0.5063image
ENSG00000235663.1,SAPCD1-AS1HNSCBAY.61.3606EAG3.4847e-030.4622image
chr6:31764941-31765442:-HNSCBAY.61.3606EER3.4847e-030.4622image
ENSG00000235663.1,SAPCD1-AS1KICHCamptothecinEAG6.1374e-030.4068image
chr6:31764941-31765442:-KICHCamptothecinEER6.1374e-030.4068image
chr6:31764941-31765442:-KIRCDasatinibEER3.5483e-04-0.2131image
ENSG00000235663.1,SAPCD1-AS1KIRCDasatinibEAG3.5483e-04-0.2131image
ENSG00000235663.1,SAPCD1-AS1KIRPBX.795EAG1.9401e-030.1885image
chr6:31764941-31765442:-KIRPBX.795EER1.9401e-030.1885image
chr6:31764941-31765442:-LGGImatinibEER4.9191e-04-0.3544image
ENSG00000235663.1,SAPCD1-AS1LGGImatinibEAG4.9191e-04-0.3544image
ENSG00000235663.1,SAPCD1-AS1LIHCAKT.inhibitor.VIIIEAG1.2512e-02-0.1828image
chr6:31764941-31765442:-LIHCAKT.inhibitor.VIIIEER1.2512e-02-0.1828image
chr6:31764941-31765442:-LUADFTI.277EER5.6410e-04-0.1819image
ENSG00000235663.1,SAPCD1-AS1LUADFTI.277EAG5.6410e-04-0.1819image
chr6:31764941-31765442:-OVDasatinibEER2.8632e-03-0.1954image
ENSG00000235663.1,SAPCD1-AS1OVDasatinibEAG3.1294e-03-0.1936image
chr6:31764941-31765442:-PCPGABT.263EER2.9144e-03-0.2276image
ENSG00000235663.1,SAPCD1-AS1PCPGABT.263EAG2.9144e-03-0.2276image
ENSG00000235663.1,SAPCD1-AS1PRADCHIR.99021EAG3.7397e-02-0.2608image
chr6:31764941-31765442:-PRADCHIR.99021EER3.7397e-02-0.2608image
ENSG00000235663.1,SAPCD1-AS1READBX.795EAG5.7503e-060.6030image
chr6:31764941-31765442:-SARCAMG.706EER2.2331e-02-0.3650image
ENSG00000235663.1,SAPCD1-AS1SARCAMG.706EAG2.2331e-02-0.3650image
ENSG00000235663.1,SAPCD1-AS1STADBI.2536EAG9.6022e-050.2466image
chr6:31764941-31765442:-STADBI.2536EER1.1228e-040.2443image
ENSG00000235663.1,SAPCD1-AS1THCAEmbelinEAG3.8810e-060.2096image
chr6:31764941-31765442:-THCAEmbelinEER3.8810e-060.2096image
ENSG00000235663.1,SAPCD1-AS1THYMBortezomibEAG9.5517e-030.3465image
chr6:31764941-31765442:-THYMBortezomibEER9.5517e-030.3465image
chr6:31764941-31765442:-UCECMetforminEER2.4041e-02-0.2339image
ENSG00000235663.1,SAPCD1-AS1UCECMetforminEAG2.4041e-02-0.2339image


Top

check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType