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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: CALCOCO2 (ImmuneEditome ID:10241)

1. Gene summary of enriched editing regions for CALCOCO2

check button Gene summary
Gene informationGene symbol

CALCOCO2

Gene ID

10241

GeneSynonymsNDP52
GeneCytomap

17q21.32

GeneTypeprotein-coding
GeneDescriptioncalcium-binding and coiled-coil domain-containing protein 2|antigen nuclear dot 52 kDa protein|nuclear domain 10 protein 52|nuclear domain 10 protein NDP52|nuclear dot protein 52
GeneModificationdate20230404
UniprotIDQ13137;H0YBP4;D6RF70;D6REB0;D6RBI4;I3L4E1;I3L493;D6RJE7;D6RBF9
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr17:48843935-48846286:+ENST00000509507.4ENSG00000136436.13CALCOCO2exonicMER3,(TG)n,AluSp,AluSx1,MIRb,(GT)n,AluSz6,MIRc,AluSz,AluSq2chr17:48843935-48846286:+.alignment
chr17:48843935-48846286:+ENST00000576582.4ENSG00000136436.13CALCOCO2exonicMER3,(TG)n,AluSp,AluSx1,MIRb,(GT)n,AluSz6,MIRc,AluSz,AluSq2chr17:48843935-48846286:+.alignment
chr17:48864073-48866171:+ENST00000510997.1ENSG00000136436.13CALCOCO2ncRNA_exonicTigger19a,AluYk3,AluSx,AluSg7chr17:48864073-48866171:+.alignment


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2. Tumor-specific enriched editing regions for CALCOCO2


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr17:48864073-48866171:+BRCAEER1.9891e-03image
ENSG00000136436.13,CALCOCO2BRCAEAG4.6871e-03image
chr17:48864073-48866171:+COADEER3.3878e-02image
ENSG00000136436.13,CALCOCO2COADEAG9.3390e-03image
chr17:48864073-48866171:+KIRCEER1.2584e-03image
ENSG00000136436.13,CALCOCO2KIRCEAG5.1512e-05image
chr17:48864073-48866171:+KIRPEER6.8484e-05image
ENSG00000136436.13,CALCOCO2KIRPEAG4.4512e-05image
chr17:48864073-48866171:+PRADEER1.7821e-02image
ENSG00000136436.13,CALCOCO2PRADEAG1.9400e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr17:48864073-48866171:+HNSCPathEER4.4804e-024.9951e-030.2328image
ENSG00000136436.13,CALCOCO2HNSCPathEAG4.4804e-024.9951e-030.2328image
ENSG00000136436.13,CALCOCO2UVMPathEAG3.6656e-024.3675e-020.3647image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr17:48864073-48866171:+LUSCEER7.4173e-044.3478e-036.6694e+02image
ENSG00000136436.13,CALCOCO2LUSCEAG7.4173e-044.3478e-036.6694e+02image

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3. Enriched editing regions and immune related genes for CALCOCO2


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for CALCOCO2


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000136436.13,CALCOCO2
KIRCEAGIRENSG00000096746.13chr1068341173:68341309:68341584:683416800.19294.0667e-024.4934e-140.4012imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZC3H7B;ZNF184NAT_cells_follicular_helperGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
ENSG00000136436.13,CALCOCO2
KIRCEAGIRENSG00000129595.8chr5112162620:112168820:112168994:1121691050.19084.1381e-021.2624e-160.4375imageNACIN1;ADAR;ALYREF;CAPRIN1;CELF2;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;LIN28;MBNL2;MOV10;MSI1;NOP56;NOP58;NUMA1;PTBP1;QKI;RBFOX2;RBM10;RBM47;SRSF1;SRSF3;TAF15;TARDBP;TIA1;TIAL1;TROVE2;U2AF1;U2AF2;UPF1;ZNF184NAEosinophilsGSVA_HALLMARK_XENOBIOTIC_METABOLISM
ENSG00000136436.13,CALCOCO2
KIRCEAGIRENSG00000165209.14chr9123159095:123159207:123160366:1231604620.16434.1616e-024.9583e-190.5110imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZC3H7B;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
ENSG00000136436.13,CALCOCO2
KIRCEAGIRENSG00000267680.1chr1944094784:44096431:44097805:440978520.21196.5815e-031.7148e-140.4217imageNACIN1;ADAR;ALYREF;BCCIP;BUD13;CAPRIN1;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZC3H7B;ZNF184NAMacrophages_M2GSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000136436.13,CALCOCO2
KIRCEAGIRENSG00000074266.13chr1186276979:86277991:86278398:862785540.19214.1670e-022.1612e-160.4332imageNACIN1;ADAR;AIFM1;ALYREF;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YWHAG;ZC3H7B;ZNF184NANK_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000136436.13,CALCOCO2
KIRCEAGIRENSG00000116741.6chr1192809038:192809181:192810165:1928102670.28394.7507e-056.8808e-140.4030imageNCNBP;CPSF6;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;FBL;FMR1;FUS;HNRNPA1;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHSRP;LARP4B;LIN28B;LSM11;MBNL2;MSI2;NOP56;NOP58;RBFOX2;RBM10;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;TAF15;TARDBP;TRA2A;U2AF1;U2AF2;UPF1RGS2Macrophages_M0GSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
ENSG00000136436.13,CALCOCO2
KIRCEAGIRENSG00000164331.5chr573554860:73555585:73557574:735576400.22106.7390e-031.1717e-180.4622imageNAIFM1;AUH;BCCIP;BUD13;CAPRIN1;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;SAFB2;SF3B4;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
ENSG00000136436.13,CALCOCO2
KIRCEAGIRENSG00000186908.10chr1276843913:76845802:76846595:768466790.21666.8454e-034.6421e-300.5829imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YWHAG;ZC3H7B;ZNF184NANK_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
ENSG00000136436.13,CALCOCO2
KIRCEAGIRENSG00000118515.7chr6134169245:134171732:134172192:1341722970.19234.2170e-025.6007e-180.4533imageNACIN1;ADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CPSF6;CSTF2T;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;RBM22;RBM47;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YWHAGSGK1T_cells_follicular_helperGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
ENSG00000136436.13,CALCOCO2
KIRCEAGIRENSG00000100567.8chr1458267473:58270485:58270933:582709980.21886.9752e-036.5108e-150.4126imageNACIN1;ADAR;AIFM1;AUH;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YWHAG;ZC3H7B;ZNF184PSMA3T_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_UP

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5. Enriched editing regions and immune infiltration for CALCOCO2


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000136436.13,CALCOCO2ACCEAGMonocytes2.3757e-02-0.3928image
ENSG00000136436.13,CALCOCO2BLCAEAGMacrophages_M24.0373e-020.1815image
chr17:48864073-48866171:+COADEERNeutrophils4.4174e-060.3615image
ENSG00000136436.13,CALCOCO2COADEAGEosinophils3.9504e-050.3180image
chr17:48864073-48866171:+GBMEERT_cells_gamma_delta4.4507e-020.1713image
ENSG00000136436.13,CALCOCO2GBMEAGPlasma_cells2.7875e-020.1872image
chr17:48864073-48866171:+HNSCEERMacrophages_M04.1989e-040.2630image
ENSG00000136436.13,CALCOCO2HNSCEAGMacrophages_M04.1989e-040.2630image
chr17:48843935-48846286:+KIRCEEREosinophils1.3644e-050.6641image
ENSG00000136436.13,CALCOCO2KIRCEAGT_cells_CD4_memory_resting2.7518e-020.1217image
chr17:48864073-48866171:+KIRPEERT_cells_CD84.8864e-020.1454image
ENSG00000136436.13,CALCOCO2KIRPEAGT_cells_CD84.3605e-020.1489image
ENSG00000136436.13,CALCOCO2LAMLEAGNeutrophils1.8187e-030.2796image
chr17:48864073-48866171:+LGGEERT_cells_CD4_naive6.3697e-040.1504image
ENSG00000136436.13,CALCOCO2LGGEAGT_cells_CD4_naive5.8016e-040.1516image
ENSG00000136436.13,CALCOCO2LUADEAGEosinophils1.1554e-030.2004image
chr17:48864073-48866171:+LUSCEERMacrophages_M13.0685e-03-0.1936image
ENSG00000136436.13,CALCOCO2LUSCEAGMacrophages_M17.0992e-04-0.2189image
ENSG00000136436.13,CALCOCO2MESOEAGNK_cells_resting1.1592e-02-0.4053image
chr17:48864073-48866171:+OVEERT_cells_gamma_delta5.6888e-040.2490image
ENSG00000136436.13,CALCOCO2OVEAGT_cells_gamma_delta5.9214e-040.2445image
chr17:48864073-48866171:+PCPGEERT_cells_follicular_helper3.4256e-020.1844image
ENSG00000136436.13,CALCOCO2PCPGEAGT_cells_follicular_helper3.4256e-020.1844image
chr17:48864073-48866171:+PRADEERT_cells_CD4_memory_resting1.5702e-020.1269image
ENSG00000136436.13,CALCOCO2PRADEAGT_cells_CD4_memory_resting1.2307e-020.1314image
ENSG00000136436.13,CALCOCO2READEAGT_cells_CD4_naive2.3358e-040.4690image
chr17:48864073-48866171:+SARCEERT_cells_CD4_memory_resting2.5739e-030.2181image
ENSG00000136436.13,CALCOCO2SARCEAGT_cells_CD4_memory_resting2.6425e-030.2175image
chr17:48864073-48866171:+SKCMEERT_cells_CD4_naive2.6370e-040.2410image
ENSG00000136436.13,CALCOCO2SKCMEAGT_cells_CD4_naive3.1517e-040.2375image
chr17:48843935-48846286:+STADEERNK_cells_activated6.3484e-030.2183image
chr17:48864073-48866171:+STADEERNK_cells_resting7.8559e-04-0.1865image
ENSG00000136436.13,CALCOCO2STADEAGNK_cells_activated3.7889e-040.1937image
ENSG00000136436.13,CALCOCO2TGCTEAGNK_cells_resting4.3354e-020.3252image
chr17:48864073-48866171:+THCAEERMacrophages_M21.0099e-020.1340image
ENSG00000136436.13,CALCOCO2THCAEAGMacrophages_M21.0777e-020.1322image
chr17:48864073-48866171:+UCECEERMast_cells_activated4.0256e-050.5954image
ENSG00000136436.13,CALCOCO2UCECEAGMast_cells_activated1.9969e-030.4534image
ENSG00000136436.13,CALCOCO2UVMEAGB_cells_memory4.6794e-02-0.3541image


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6. Enriched editing regions and immune gene sets for CALCOCO2


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr17:48864073-48866171:+BRCAEER2.6463e-02image8.2485e-04-0.1185image
ENSG00000136436.13,CALCOCO2BRCAEAG1.7120e-02image8.4418e-05-0.1385image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr17:48864073-48866171:+LGGEER5.9916e-08-0.23674.7303e-03-0.12479.7477e-04-0.14533.2478e-07-0.2235image
ENSG00000136436.13,CALCOCO2LGGEAG3.1686e-08-0.24145.2462e-03-0.12328.5177e-04-0.14701.9888e-07-0.2274image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000136436.13,CALCOCO2ACCGSVA_HALLMARK_ANDROGEN_RESPONSEEAG4.1052e-02-0.3576image
chr17:48864073-48866171:+BLCAGSVA_HALLMARK_GLYCOLYSISEER6.8751e-03-0.2406image
ENSG00000136436.13,CALCOCO2BLCAGSVA_HALLMARK_GLYCOLYSISEAG8.1428e-05-0.3411image
ENSG00000136436.13,CALCOCO2BRCAGSVA_HALLMARK_ANGIOGENESISEAG6.4801e-06-0.1587image
chr17:48864073-48866171:+BRCAGSVA_HALLMARK_ANGIOGENESISEER1.1176e-04-0.1368image
chr17:48864073-48866171:+CESCGSVA_HALLMARK_P53_PATHWAYEER4.1583e-02-0.1938image
ENSG00000136436.13,CALCOCO2CESCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG4.5337e-02-0.1904image
ENSG00000136436.13,CALCOCO2COADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG7.3790e-08-0.4086image
chr17:48864073-48866171:+COADGSVA_HALLMARK_NOTCH_SIGNALINGEER2.6172e-03-0.2417image
chr17:48864073-48866171:+ESCAGSVA_HALLMARK_COAGULATIONEER1.6847e-02-0.2003image
ENSG00000136436.13,CALCOCO2ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.3415e-03-0.2639image
chr17:48864073-48866171:+GBMGSVA_HALLMARK_PROTEIN_SECRETIONEER4.8910e-02-0.1680image
chr17:48864073-48866171:+HNSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER9.6244e-04-0.2467image
ENSG00000136436.13,CALCOCO2HNSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG9.6244e-04-0.2467image
chr17:48843935-48846286:+KIRCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER1.7586e-02-0.3990image
ENSG00000136436.13,CALCOCO2KIRCGSVA_HALLMARK_UV_RESPONSE_UPEAG8.0204e-05-0.2160image
chr17:48864073-48866171:+KIRCGSVA_HALLMARK_UV_RESPONSE_UPEER1.8921e-02-0.1301image
ENSG00000136436.13,CALCOCO2KIRPGSVA_HALLMARK_ADIPOGENESISEAG6.8083e-03-0.1988image
chr17:48864073-48866171:+KIRPGSVA_HALLMARK_ADIPOGENESISEER1.0339e-02-0.1886image
chr17:48864073-48866171:+LAMLGSVA_HALLMARK_MYC_TARGETS_V1EER6.1919e-03-0.2619image
chr17:48843935-48846286:+LAMLGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.8218e-020.2796image
ENSG00000136436.13,CALCOCO2LAMLGSVA_HALLMARK_MYC_TARGETS_V1EAG2.4737e-02-0.2033image
chr17:48864073-48866171:+LGGGSVA_HALLMARK_COAGULATIONEER7.9760e-10-0.2673image
ENSG00000136436.13,CALCOCO2LGGGSVA_HALLMARK_COAGULATIONEAG4.6645e-10-0.2708image
chr17:48864073-48866171:+LIHCGSVA_HALLMARK_MYC_TARGETS_V2EER3.7773e-020.1715image
ENSG00000136436.13,CALCOCO2LIHCGSVA_HALLMARK_MYC_TARGETS_V2EAG1.4687e-020.2002image
chr17:48864073-48866171:+LUADGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER3.0610e-02-0.1379image
ENSG00000136436.13,CALCOCO2LUADGSVA_HALLMARK_P53_PATHWAYEAG1.1421e-05-0.2684image
chr17:48864073-48866171:+LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.2103e-05-0.2746image
ENSG00000136436.13,CALCOCO2LUSCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG2.1090e-05-0.2730image
ENSG00000136436.13,CALCOCO2MESOGSVA_HALLMARK_UV_RESPONSE_DNEAG2.0723e-040.5668image
chr17:48864073-48866171:+OVGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER5.6870e-04-0.2490image
ENSG00000136436.13,CALCOCO2OVGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG1.8371e-04-0.2654image
chr17:48864073-48866171:+PAADGSVA_HALLMARK_APICAL_SURFACEEER2.0918e-03-0.2760image
ENSG00000136436.13,CALCOCO2PAADGSVA_HALLMARK_APICAL_SURFACEEAG4.8793e-04-0.3086image
ENSG00000136436.13,CALCOCO2PCPGGSVA_HALLMARK_NOTCH_SIGNALINGEAG3.7429e-02-0.1814image
chr17:48864073-48866171:+PCPGGSVA_HALLMARK_NOTCH_SIGNALINGEER3.7429e-02-0.1814image
ENSG00000136436.13,CALCOCO2PRADGSVA_HALLMARK_GLYCOLYSISEAG6.4882e-05-0.2084image
chr17:48864073-48866171:+PRADGSVA_HALLMARK_GLYCOLYSISEER1.6905e-04-0.1964image
ENSG00000136436.13,CALCOCO2READGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG2.1190e-02-0.3047image
chr17:48864073-48866171:+SARCGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER1.0616e-06-0.3462image
ENSG00000136436.13,CALCOCO2SARCGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG9.4804e-07-0.3477image
ENSG00000136436.13,CALCOCO2SKCMGSVA_HALLMARK_PROTEIN_SECRETIONEAG3.3085e-04-0.2367image
chr17:48864073-48866171:+SKCMGSVA_HALLMARK_PROTEIN_SECRETIONEER5.4809e-04-0.2286image
chr17:48864073-48866171:+STADGSVA_HALLMARK_PROTEIN_SECRETIONEER8.9685e-06-0.2450image
chr17:48843935-48846286:+STADGSVA_HALLMARK_MYC_TARGETS_V1EER4.4145e-020.1619image
ENSG00000136436.13,CALCOCO2STADGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.4518e-07-0.2833image
ENSG00000136436.13,CALCOCO2TGCTGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.5702e-05-0.6046image
ENSG00000136436.13,CALCOCO2THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG5.9803e-04-0.1774image
chr17:48864073-48866171:+THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER1.8637e-03-0.1617image
ENSG00000136436.13,CALCOCO2UCECGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.1630e-03-0.4503image
ENSG00000136436.13,CALCOCO2UCSGSVA_HALLMARK_PEROXISOMEEAG1.7729e-02-0.4796image
ENSG00000136436.13,CALCOCO2UVMGSVA_HALLMARK_APICAL_SURFACEEAG4.0433e-040.5878image


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7. Enriched editing regions and drugs for CALCOCO2


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr17:48864073-48866171:+BLCACGP.082996EER1.9765e-020.2083image
ENSG00000136436.13,CALCOCO2BLCAA.443654EAG3.3527e-040.3121image
ENSG00000136436.13,CALCOCO2BRCAAZ628EAG1.7617e-030.1104image
chr17:48864073-48866171:+BRCABIBW2992EER1.0755e-02-0.0907image
chr17:48864073-48866171:+CESCDMOGEER5.7730e-030.2604image
ENSG00000136436.13,CALCOCO2CESCDMOGEAG1.1777e-040.3574image
chr17:48864073-48866171:+COADGW843682XEER2.4636e-060.3703image
ENSG00000136436.13,CALCOCO2COADBMS.509744EAG1.8394e-100.4755image
ENSG00000136436.13,CALCOCO2GBMLapatinibEAG2.1374e-020.1958image
chr17:48864073-48866171:+HNSCCI.1040EER4.5627e-030.2129image
ENSG00000136436.13,CALCOCO2HNSCCI.1040EAG4.5627e-030.2129image
ENSG00000136436.13,CALCOCO2KICHErlotinibEAG2.9605e-05-0.6369image
chr17:48864073-48866171:+KICHErlotinibEER2.9605e-05-0.6369image
chr17:48843935-48846286:+KIRCKU.55933EER1.0343e-040.6090image
ENSG00000136436.13,CALCOCO2KIRCGW843682XEAG2.7799e-080.3007image
chr17:48864073-48866171:+KIRCJW.7.52.1EER4.5429e-030.1570image
ENSG00000136436.13,CALCOCO2KIRPIPA.3EAG1.4135e-02-0.1806image
chr17:48864073-48866171:+KIRPIPA.3EER1.6800e-02-0.1761image
chr17:48843935-48846286:+LAMLFTI.277EER2.3516e-02-0.2686image
ENSG00000136436.13,CALCOCO2LAMLEtoposideEAG3.6584e-030.2612image
chr17:48864073-48866171:+LAMLGemcitabineEER2.4398e-020.2165image
ENSG00000136436.13,CALCOCO2LGGKU.55933EAG2.0652e-100.2764image
chr17:48864073-48866171:+LGGKU.55933EER3.3054e-100.2733image
ENSG00000136436.13,CALCOCO2LIHCCEP.701EAG9.5233e-03-0.2125image
chr17:48864073-48866171:+LIHCErlotinibEER3.9151e-02-0.1818image
chr17:48864073-48866171:+LUADBexaroteneEER1.6677e-020.1525image
ENSG00000136436.13,CALCOCO2LUADBexaroteneEAG3.4477e-060.2833image
chr17:48864073-48866171:+LUSCGemcitabineEER2.4136e-030.1983image
ENSG00000136436.13,CALCOCO2LUSCMG.132EAG1.2192e-020.1633image
ENSG00000136436.13,CALCOCO2MESOMidostaurinEAG1.1291e-03-0.5080image
chr17:48864073-48866171:+OVGDC.0449EER9.4173e-06-0.3168image
ENSG00000136436.13,CALCOCO2OVGDC.0449EAG4.7396e-06-0.3218image
ENSG00000136436.13,CALCOCO2PAADKU.55933EAG1.8170e-020.2127image
chr17:48864073-48866171:+PCPGLenalidomideEER4.3172e-02-0.1763image
ENSG00000136436.13,CALCOCO2PCPGLenalidomideEAG4.3172e-02-0.1763image
ENSG00000136436.13,CALCOCO2PRADCCT007093EAG1.4272e-04-0.1986image
chr17:48864073-48866171:+PRADCCT007093EER3.7782e-04-0.1859image
ENSG00000136436.13,CALCOCO2READGefitinibEAG1.9003e-020.3098image
chr17:48864073-48866171:+SARCMethotrexateEER1.6852e-040.2710image
ENSG00000136436.13,CALCOCO2SARCMethotrexateEAG1.7565e-040.2703image
chr17:48864073-48866171:+SKCMBMS.509744EER4.9212e-04-0.2305image
ENSG00000136436.13,CALCOCO2SKCMBMS.509744EAG1.7293e-04-0.2473image
ENSG00000136436.13,CALCOCO2STADEHT.1864EAG2.0955e-03-0.1680image
chr17:48843935-48846286:+STADAZD6482EER3.0032e-020.1744image
chr17:48864073-48866171:+STADBMS.536924EER3.6651e-05-0.2282image
ENSG00000136436.13,CALCOCO2THCAAMG.706EAG4.1041e-04-0.1825image
chr17:48864073-48866171:+THCAAMG.706EER2.5206e-04-0.1897image
chr17:48864073-48866171:+THYMElesclomolEER7.4222e-030.3342image
ENSG00000136436.13,CALCOCO2THYMJNK.9LEAG4.9731e-030.3470image
chr17:48864073-48866171:+UCECATRAEER1.3384e-030.4842image
ENSG00000136436.13,CALCOCO2UCECA.770041EAG1.4941e-07-0.6968image
ENSG00000136436.13,CALCOCO2UCSAZD.0530EAG3.2444e-02-0.4377image
ENSG00000136436.13,CALCOCO2UVMGW.441756EAG5.1640e-03-0.4825image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType