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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: AP3S2 (ImmuneEditome ID:10239)

1. Gene summary of enriched editing regions for AP3S2

check button Gene summary
Gene informationGene symbol

AP3S2

Gene ID

10239

GeneSynonymsAP3S3|sigma3b
GeneCytomap

15q26.1

GeneTypeprotein-coding
GeneDescriptionAP-3 complex subunit sigma-2|AP-3 complex subunit sigma-3B|adapter-related protein complex 3 subunit sigma-2|adaptor complex sigma3B|adaptor related protein complex 3 sigma 2 subunit|clathrin-associated/assembly/adaptor protein, small 4, 22-kD|sigma-3B-adaptin|sigma-adaptin 3b
GeneModificationdate20230409
UniprotIDP59780;A0A024RC62;H0YLI7;A0A087WY05;H0YLX6;H0YNI6;H0YN38;H0YKM3
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr15:89832151-89832810:-ENST00000336418.7ENSG00000157823.15AP3S2UTR3AluY,AluJrchr15:89832151-89832810:-.alignment
chr15:89846901-89847180:-ENST00000558186.1ENSG00000157823.15AP3S2ncRNA_intronicAluSx,AluJochr15:89846901-89847180:-.alignment
chr15:89846901-89847180:-ENST00000559162.4ENSG00000157823.15AP3S2ncRNA_intronicAluSx,AluJochr15:89846901-89847180:-.alignment
chr15:89846901-89847180:-ENST00000561410.4ENSG00000157823.15AP3S2ncRNA_intronicAluSx,AluJochr15:89846901-89847180:-.alignment
chr15:89856279-89858284:-ENST00000559162.4ENSG00000157823.15AP3S2ncRNA_intronicAluSp,MLT1I,L2c,AluSz,AluSz6,AluSx3chr15:89856279-89858284:-.alignment
chr15:89859392-89860018:-ENST00000559162.4ENSG00000157823.15AP3S2ncRNA_intronicAluY,AluSx,(TTTC)nchr15:89859392-89860018:-.alignment
chr15:89873304-89874797:-ENST00000559162.4ENSG00000157823.15AP3S2ncRNA_intronicLTR7B,HAL1,L1M3,AluSx3,AluJo,AluSzchr15:89873304-89874797:-.alignment
chr15:89873304-89874797:-ENST00000560184.4ENSG00000157823.15AP3S2ncRNA_intronicLTR7B,HAL1,L1M3,AluSx3,AluJo,AluSzchr15:89873304-89874797:-.alignment
chr15:89885231-89886232:-ENST00000559162.4ENSG00000157823.15AP3S2ncRNA_intronicAluSc5,AluSz6,AluJbchr15:89885231-89886232:-.alignment
chr15:89885231-89886232:-ENST00000560184.4ENSG00000157823.15AP3S2ncRNA_intronicAluSc5,AluSz6,AluJbchr15:89885231-89886232:-.alignment


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2. Tumor-specific enriched editing regions for AP3S2


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr15:89832151-89832810:-BRCAEER5.8413e-05image
ENSG00000157823.15,AP3S2BRCAEAG7.1941e-04image
chr15:89832151-89832810:-COADEER1.3847e-12image
ENSG00000157823.15,AP3S2COADEAG1.0425e-10image
chr15:89832151-89832810:-KICHEER2.1436e-10image
ENSG00000157823.15,AP3S2KICHEAG2.1436e-10image
chr15:89832151-89832810:-KIRCEER7.7435e-08image
ENSG00000157823.15,AP3S2KIRCEAG5.7268e-07image
chr15:89832151-89832810:-KIRPEER6.4514e-08image
ENSG00000157823.15,AP3S2KIRPEAG8.2238e-08image
chr15:89832151-89832810:-LUSCEER5.9723e-03image
ENSG00000157823.15,AP3S2LUSCEAG1.2724e-03image
chr15:89832151-89832810:-PRADEER1.4728e-06image
ENSG00000157823.15,AP3S2PRADEAG6.0606e-06image
chr15:89832151-89832810:-THCAEER9.3676e-03image
ENSG00000157823.15,AP3S2THCAEAG3.3791e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr15:89832151-89832810:-CESCCliEER2.3983e-022.3252e-020.1537image
chr15:89873304-89874797:-STADPathEER2.2339e-021.3625e-020.2247image
chr15:89856279-89858284:-STADPathEER2.2701e-028.6224e-030.4003image
ENSG00000157823.15,AP3S2TGCTCliEAG3.4012e-029.2076e-030.4018image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr15:89873304-89874797:-ESCAEER1.1742e-021.7981e-021.2448e+02image

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3. Enriched editing regions and immune related genes for AP3S2


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr15:89832151-89832810:-GBMEERENSG00000240759,RP11-25I15.10.31326.2060e-037.1020e-100.4630imageNNNANeutrophilsGSVA_HALLMARK_KRAS_SIGNALING_DN
chr15:89832151-89832810:-GBMEERENSG00000217026,RPL10P10.30408.3643e-031.3379e-070.4023imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_KRAS_SIGNALING_DN
chr15:89832151-89832810:-GBMEERENSG00000228665,RP11-20O24.10.29829.2438e-031.6596e-110.5001imageNNNAGSVA_HALLMARK_KRAS_SIGNALING_DN
chr15:89832151-89832810:-GBMEERENSG00000180211,RP1-278E11.30.27491.9267e-028.6895e-080.4078imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_APICAL_JUNCTION
chr15:89832151-89832810:-GBMEERENSG00000219451,AC005251.30.27252.0700e-022.4883e-080.4231imageNNNAT_cells_follicular_helperGSVA_HALLMARK_KRAS_SIGNALING_DN
chr15:89832151-89832810:-GBMEERENSG00000224094,RPS24P80.25213.3915e-024.9303e-080.4148imageNNNAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr15:89832151-89832810:-GBMEERENSG00000225093,RPL3P70.24703.7688e-023.4680e-080.4191imageNNNAPlasma_cellsGSVA_HALLMARK_BILE_ACID_METABOLISM
chr15:89832151-89832810:-PRADEERENSG00000169020,ATP5I0.32455.6303e-109.4510e-210.4192imageNEIF4A3;ELAVL1;FBL;HNRNPC;NOP56;RBM10;U2AF2NAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr15:89832151-89832810:-KIRCEERENSG00000125107,CNOT1-0.33912.3129e-086.6961e-16-0.4078imageNEIF4A3;ELAVL1;FBL;HNRNPC;NOP56;RBM10;RBM5;U2AF2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
chr15:89832151-89832810:-KIRPEERENSG00000140382,HMG20A-0.34031.7554e-064.8469e-12-0.4100imageNEIF4A3;ELAVL1;FBL;HNRNPC;NOP56;RBM10;RBM5;U2AF2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE

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4. Enriched editing regions and immune related splicing for AP3S2


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr15:89832151-89832810:-
ESCAEERIRENSG00000189339.7chr11669663:1669736:1670097:16701510.40262.9427e-034.4266e-090.4456imageNEIF4A3;ELAVL1;FBL;HNRNPC;NOP56;RBM10;U2AF2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HEME_METABOLISM
chr15:89832151-89832810:-
ESCAEERIRENSG00000132142.15chr1737200138:37200183:37200426:372004830.46859.3161e-052.2637e-120.5253imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_BILE_ACID_METABOLISM
chr15:89832151-89832810:-
ESCAEERIRENSG00000101596.10chr182726451:2726524:2728456:27285960.36271.0668e-022.7119e-080.4270imageNEIF4A3;ELAVL1;FBL;HNRNPC;NOP56;RBM10;RBM5;U2AF2NAT_cells_CD4_memory_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr15:89832151-89832810:-
ESCAEERIRENSG00000177084.12chr12132668634:132668737:132668810:1326689390.33203.4456e-022.6275e-080.4274imageNEIF4A3;ELAVL1;FBL;HNRNPC;NOP56;RBM10;U2AF2NAT_cells_CD4_memory_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr15:89832151-89832810:-
ESCAEERIRENSG00000062650.13chr1086497200:86497319:86499717:865007430.42151.0468e-031.1224e-090.4607imageNEIF4A3;ELAVL1;FBL;HNRNPC;NOP56;RBM10;RBM5;U2AF2NANK_cells_activatedGSVA_HALLMARK_HEME_METABOLISM
chr15:89832151-89832810:-
ESCAEERMEXENSG00000135446.12chr1257748590:57748617:57749181:57749317:57751206:57751736:57752174:577522760.45022.2149e-045.1578e-100.4689imageNEIF4A3;ELAVL1;FBL;HNRNPC;NOP56;RBM10;U2AF2CDK4T_cells_CD4_memory_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr15:89832151-89832810:-
ESCAEERMEXENSG00000001036.9chr6143501944:143502122:143502354:143502560:143504166:143504252:143507236:1435074240.40812.2588e-031.0763e-080.4355imageNEIF4A3;ELAVL1;FBL;HNRNPC;NOP56;RBM10;U2AF2NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr15:89832151-89832810:-
ESCAEERIRENSG00000169871.8chr7101085438:101085571:101087005:1010871680.37625.3634e-037.0897e-090.4441imageNEIF4A3;ELAVL1;FBL;HNRNPC;NOP56;RBM10;U2AF2TRIM56T_cells_gamma_deltaGSVA_HALLMARK_MITOTIC_SPINDLE
chr15:89832151-89832810:-
ESCAEERA5ENSG00000158201.5chr1821659179:21659343:21664117:21664230:21663677:21664230-0.34442.4728e-025.0198e-09-0.4442imageNEIF4A3;ELAVL1;FBL;HNRNPC;NOP56;RBM10;U2AF2NAT_cells_gamma_deltaGSVA_HALLMARK_BILE_ACID_METABOLISM
chr15:89832151-89832810:-
ESCAEERMEXENSG00000172053.10chr349095993:49096079:49097991:49098480:49098549:49098692:49098884:490989890.45122.4025e-042.2959e-090.4529imageNEIF4A3;ELAVL1;FBL;HNRNPC;NOP56;RBM10;RBM5;U2AF2NAT_cells_CD8GSVA_HALLMARK_MITOTIC_SPINDLE

More results



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5. Enriched editing regions and immune infiltration for AP3S2


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr15:89832151-89832810:-ACCEERNK_cells_activated2.3248e-020.2951image
ENSG00000157823.15,AP3S2ACCEAGNK_cells_activated1.7838e-020.3075image
chr15:89832151-89832810:-BRCAEERNK_cells_activated4.0683e-050.1326image
ENSG00000157823.15,AP3S2BRCAEAGNK_cells_activated1.0531e-040.1247image
chr15:89832151-89832810:-CESCEERT_cells_CD4_naive6.5446e-030.1824image
ENSG00000157823.15,AP3S2CESCEAGT_cells_CD4_naive5.0023e-030.1869image
chr15:89832151-89832810:-CHOLEERMast_cells_activated1.0321e-030.5777image
ENSG00000157823.15,AP3S2CHOLEAGMast_cells_activated8.2202e-040.5867image
chr15:89832151-89832810:-COADEERMast_cells_activated6.3289e-030.1788image
ENSG00000157823.15,AP3S2COADEAGT_cells_CD4_memory_resting9.9106e-03-0.1672image
chr15:89832151-89832810:-ESCAEERT_cells_gamma_delta2.2041e-050.3306image
chr15:89859392-89860018:-ESCAEERB_cells_naive2.1982e-02-0.3861image
chr15:89873304-89874797:-ESCAEERT_cells_CD82.5553e-02-0.2931image
ENSG00000157823.15,AP3S2ESCAEAGT_cells_gamma_delta1.2796e-060.3720image
chr15:89832151-89832810:-HNSCEERT_cells_CD4_memory_resting2.3348e-02-0.1226image
ENSG00000157823.15,AP3S2HNSCEAGT_cells_CD4_memory_resting2.0713e-02-0.1243image
chr15:89832151-89832810:-KICHEERNK_cells_resting2.1014e-02-0.2880image
ENSG00000157823.15,AP3S2KICHEAGNK_cells_resting2.1014e-02-0.2880image
chr15:89832151-89832810:-KIRCEERNK_cells_activated2.5585e-040.1913image
ENSG00000157823.15,AP3S2KIRCEAGNK_cells_activated1.3545e-040.1984image
chr15:89832151-89832810:-KIRPEERT_cells_regulatory_(Tregs)7.4908e-030.1649image
ENSG00000157823.15,AP3S2KIRPEAGT_cells_regulatory_(Tregs)3.8460e-020.1280image
chr15:89832151-89832810:-LGGEERNK_cells_activated1.1735e-030.1414image
ENSG00000157823.15,AP3S2LGGEAGNK_cells_activated1.2103e-020.1095image
chr15:89832151-89832810:-LIHCEERT_cells_CD4_memory_resting1.0676e-02-0.1722image
ENSG00000157823.15,AP3S2LIHCEAGT_cells_CD4_memory_resting2.7010e-02-0.1452image
ENSG00000157823.15,AP3S2LUADEAGMonocytes4.4492e-02-0.1014image
chr15:89832151-89832810:-LUSCEERMacrophages_M12.9900e-03-0.1546image
ENSG00000157823.15,AP3S2LUSCEAGMacrophages_M14.9780e-04-0.1792image
chr15:89832151-89832810:-MESOEERMacrophages_M01.2128e-030.3765image
ENSG00000157823.15,AP3S2MESOEAGMacrophages_M02.8060e-030.3472image
chr15:89832151-89832810:-OVEERB_cells_memory6.7146e-040.2010image
chr15:89873304-89874797:-OVEERNK_cells_resting4.7092e-030.4230image
ENSG00000157823.15,AP3S2OVEAGT_cells_CD82.6579e-040.2148image
chr15:89832151-89832810:-PAADEERMacrophages_M14.5666e-03-0.2392image
ENSG00000157823.15,AP3S2PAADEAGDendritic_cells_resting1.2012e-02-0.2118image
chr15:89832151-89832810:-PCPGEERT_cells_CD81.1446e-020.2046image
ENSG00000157823.15,AP3S2PCPGEAGNK_cells_resting6.6174e-030.2166image
chr15:89832151-89832810:-PRADEERT_cells_CD4_memory_resting1.7014e-03-0.1469image
ENSG00000157823.15,AP3S2PRADEAGT_cells_CD4_memory_resting3.9278e-03-0.1345image
ENSG00000157823.15,AP3S2READEAGT_cells_CD4_naive4.8798e-020.2083image
chr15:89832151-89832810:-SARCEERMacrophages_M02.7549e-050.2844image
ENSG00000157823.15,AP3S2SARCEAGMacrophages_M07.2290e-050.2679image
chr15:89832151-89832810:-SKCMEERT_cells_CD4_memory_resting1.4412e-02-0.1195image
ENSG00000157823.15,AP3S2SKCMEAGT_cells_CD4_memory_resting1.7242e-02-0.1162image
chr15:89832151-89832810:-STADEERNeutrophils1.9539e-040.1959image
chr15:89873304-89874797:-STADEERMast_cells_resting6.2687e-03-0.2452image
ENSG00000157823.15,AP3S2STADEAGNeutrophils2.5715e-040.1918image
chr15:89832151-89832810:-TGCTEERNK_cells_activated3.1790e-020.2516image
ENSG00000157823.15,AP3S2TGCTEAGNK_cells_activated9.0870e-030.2936image
chr15:89832151-89832810:-THCAEERB_cells_naive2.3707e-05-0.1908image
ENSG00000157823.15,AP3S2THCAEAGB_cells_naive5.2153e-05-0.1821image
chr15:89832151-89832810:-THYMEERT_cells_regulatory_(Tregs)1.8862e-040.3798image
ENSG00000157823.15,AP3S2THYMEAGT_cells_regulatory_(Tregs)7.5797e-050.3986image
chr15:89832151-89832810:-UCECEERT_cells_regulatory_(Tregs)1.2773e-020.2601image
ENSG00000157823.15,AP3S2UCECEAGB_cells_naive1.4693e-040.3672image
chr15:89832151-89832810:-UCSEERNK_cells_activated1.6173e-020.4156image
ENSG00000157823.15,AP3S2UCSEAGNK_cells_activated1.8039e-020.3975image
chr15:89832151-89832810:-UVMEERMacrophages_M12.4751e-02-0.2609image
ENSG00000157823.15,AP3S2UVMEAGMacrophages_M11.7953e-02-0.2726image


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6. Enriched editing regions and immune gene sets for AP3S2


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
ENSG00000157823.15,AP3S2HNSCEAG3.6698e-02image3.5951e-02-0.1128image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr15:89832151-89832810:-THYMEER4.7536e-040.35711.5344e-030.32574.5945e-03-0.29304.1157e-04-0.3607image
ENSG00000157823.15,AP3S2THYMEAG2.3837e-030.31136.2330e-040.34831.0973e-02-0.26271.3903e-03-0.3268image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr15:89832151-89832810:-ACCGSVA_HALLMARK_PROTEIN_SECRETIONEER4.1305e-02-0.2665image
ENSG00000157823.15,AP3S2ACCGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.5888e-02-0.2900image
ENSG00000157823.15,AP3S2BLCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG4.9755e-02-0.1316image
ENSG00000157823.15,AP3S2BRCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.4476e-07-0.1655image
chr15:89832151-89832810:-BRCAGSVA_HALLMARK_PROTEIN_SECRETIONEER3.4773e-10-0.2016image
chr15:89832151-89832810:-CESCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER5.8319e-03-0.1849image
ENSG00000157823.15,AP3S2CESCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG1.6170e-02-0.1605image
chr15:89832151-89832810:-CHOLGSVA_HALLMARK_SPERMATOGENESISEER2.0081e-030.5497image
ENSG00000157823.15,AP3S2CHOLGSVA_HALLMARK_SPERMATOGENESISEAG5.3904e-040.6028image
ENSG00000157823.15,AP3S2COADGSVA_HALLMARK_DNA_REPAIREAG1.0703e-030.2112image
chr15:89832151-89832810:-COADGSVA_HALLMARK_DNA_REPAIREER4.5238e-030.1858image
chr15:89859392-89860018:-ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER1.2348e-020.4185image
ENSG00000157823.15,AP3S2ESCAGSVA_HALLMARK_HYPOXIAEAG1.8368e-020.1862image
chr15:89832151-89832810:-ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER2.0184e-05-0.3321image
chr15:89832151-89832810:-GBMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.8869e-02-0.1635image
chr15:89832151-89832810:-HNSCGSVA_HALLMARK_UV_RESPONSE_DNEER9.9197e-04-0.1773image
ENSG00000157823.15,AP3S2HNSCGSVA_HALLMARK_UV_RESPONSE_DNEAG2.2388e-03-0.1638image
chr15:89832151-89832810:-KICHGSVA_HALLMARK_ANGIOGENESISEER9.4500e-040.4035image
ENSG00000157823.15,AP3S2KICHGSVA_HALLMARK_ANGIOGENESISEAG9.4500e-040.4035image
chr15:89832151-89832810:-KIRCGSVA_HALLMARK_PROTEIN_SECRETIONEER2.4392e-07-0.2677image
ENSG00000157823.15,AP3S2KIRCGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.6172e-06-0.2480image
chr15:89832151-89832810:-KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEER8.9407e-11-0.3867image
ENSG00000157823.15,AP3S2KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.3217e-10-0.3734image
ENSG00000157823.15,AP3S2LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.0850e-03-0.3700image
ENSG00000157823.15,AP3S2LGGGSVA_HALLMARK_UV_RESPONSE_DNEAG1.5614e-10-0.2748image
chr15:89832151-89832810:-LGGGSVA_HALLMARK_UV_RESPONSE_DNEER1.8552e-12-0.3013image
chr15:89832151-89832810:-LIHCGSVA_HALLMARK_ADIPOGENESISEER8.2600e-04-0.2244image
ENSG00000157823.15,AP3S2LIHCGSVA_HALLMARK_ADIPOGENESISEAG9.0049e-04-0.2165image
chr15:89832151-89832810:-LUADGSVA_HALLMARK_ANDROGEN_RESPONSEEER5.4263e-030.1411image
ENSG00000157823.15,AP3S2LUADGSVA_HALLMARK_ANDROGEN_RESPONSEEAG3.0142e-030.1493image
chr15:89832151-89832810:-LUSCGSVA_HALLMARK_SPERMATOGENESISEER2.5933e-04-0.1896image
ENSG00000157823.15,AP3S2LUSCGSVA_HALLMARK_SPERMATOGENESISEAG1.2439e-03-0.1663image
chr15:89832151-89832810:-MESOGSVA_HALLMARK_MYC_TARGETS_V2EER1.3350e-030.3735image
ENSG00000157823.15,AP3S2MESOGSVA_HALLMARK_MYC_TARGETS_V2EAG1.6706e-030.3640image
chr15:89873304-89874797:-OVGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.1062e-020.3838image
chr15:89832151-89832810:-OVGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER6.7496e-04-0.2009image
ENSG00000157823.15,AP3S2OVGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.0369e-02-0.1519image
chr15:89832151-89832810:-PAADGSVA_HALLMARK_UV_RESPONSE_DNEER1.2348e-02-0.2117image
ENSG00000157823.15,AP3S2PAADGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.0467e-02-0.2157image
ENSG00000157823.15,AP3S2PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEAG7.5421e-04-0.2670image
chr15:89832151-89832810:-PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEER9.8246e-08-0.4160image
ENSG00000157823.15,AP3S2PRADGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.6482e-12-0.3192image
chr15:89832151-89832810:-PRADGSVA_HALLMARK_MITOTIC_SPINDLEEER3.8769e-15-0.3576image
ENSG00000157823.15,AP3S2SARCGSVA_HALLMARK_ANGIOGENESISEAG1.1573e-040.2605image
chr15:89832151-89832810:-SARCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER3.5224e-050.2807image
ENSG00000157823.15,AP3S2SKCMGSVA_HALLMARK_UV_RESPONSE_DNEAG9.9536e-04-0.1601image
chr15:89832151-89832810:-SKCMGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER1.5586e-04-0.1837image
chr15:89856279-89858284:-STADGSVA_HALLMARK_ADIPOGENESISEER3.8541e-02-0.3095image
chr15:89859392-89860018:-STADGSVA_HALLMARK_NOTCH_SIGNALINGEER7.4090e-040.3741image
chr15:89873304-89874797:-STADGSVA_HALLMARK_NOTCH_SIGNALINGEER1.8405e-030.2781image
chr15:89832151-89832810:-STADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.1315e-04-0.1948image
ENSG00000157823.15,AP3S2STADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.2151e-02-0.1131image
ENSG00000157823.15,AP3S2TGCTGSVA_HALLMARK_NOTCH_SIGNALINGEAG3.0761e-040.3980image
chr15:89832151-89832810:-TGCTGSVA_HALLMARK_NOTCH_SIGNALINGEER6.3811e-040.3904image
chr15:89832151-89832810:-THCAGSVA_HALLMARK_HEME_METABOLISMEER1.2815e-13-0.3282image
ENSG00000157823.15,AP3S2THCAGSVA_HALLMARK_HEME_METABOLISMEAG2.9780e-09-0.2644image
ENSG00000157823.15,AP3S2THYMGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG5.3274e-06-0.4523image
chr15:89832151-89832810:-THYMGSVA_HALLMARK_PROTEIN_SECRETIONEER4.2315e-08-0.5339image
chr15:89832151-89832810:-UCECGSVA_HALLMARK_MYC_TARGETS_V1EER4.1136e-04-0.3627image
ENSG00000157823.15,AP3S2UCECGSVA_HALLMARK_BILE_ACID_METABOLISMEAG7.6590e-030.2626image
chr15:89832151-89832810:-UCSGSVA_HALLMARK_ANDROGEN_RESPONSEEER7.1495e-03-0.4594image
chr15:89832151-89832810:-UVMGSVA_HALLMARK_PEROXISOMEEER7.3174e-04-0.3840image
ENSG00000157823.15,AP3S2UVMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.7210e-03-0.3414image


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7. Enriched editing regions and drugs for AP3S2


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr15:89832151-89832810:-ACCEmbelinEER3.4980e-030.3743image
ENSG00000157823.15,AP3S2ACCEmbelinEAG2.3873e-030.3881image
ENSG00000157823.15,AP3S2BRCACEP.701EAG1.0541e-09-0.1951image
chr15:89832151-89832810:-BRCACCT007093EER5.1860e-120.2212image
chr15:89832151-89832810:-CESCGSK.650394EER5.7773e-05-0.2671image
ENSG00000157823.15,AP3S2CESCGSK.650394EAG8.4568e-04-0.2215image
chr15:89832151-89832810:-CHOLAZD8055EER1.3546e-020.4532image
ENSG00000157823.15,AP3S2CHOLGDC0941EAG8.0694e-030.4822image
ENSG00000157823.15,AP3S2COADGW843682XEAG8.0884e-04-0.2161image
chr15:89832151-89832810:-COADBI.D1870EER5.2214e-03-0.1828image
ENSG00000157823.15,AP3S2ESCAGNF.2EAG4.9660e-04-0.2722image
chr15:89832151-89832810:-ESCAGefitinibEER1.8889e-03-0.2461image
chr15:89859392-89860018:-ESCACGP.60474EER2.4157e-02-0.3805image
chr15:89832151-89832810:-GBMLFM.A13EER2.1859e-020.1812image
chr15:89832151-89832810:-HNSCEmbelinEER3.2172e-050.2228image
ENSG00000157823.15,AP3S2HNSCEmbelinEAG3.9185e-050.2192image
chr15:89832151-89832810:-KICHEHT.1864EER5.6712e-040.4191image
ENSG00000157823.15,AP3S2KICHEHT.1864EAG5.6712e-040.4191image
chr15:89832151-89832810:-KIRCBMS.536924EER5.4113e-08-0.2821image
ENSG00000157823.15,AP3S2KIRCBMS.536924EAG5.0465e-05-0.2111image
ENSG00000157823.15,AP3S2KIRPAZD6244EAG2.3729e-06-0.2867image
chr15:89832151-89832810:-KIRPGW843682XEER2.4341e-07-0.3124image
ENSG00000157823.15,AP3S2LAMLJNK.9LEAG6.5770e-04-0.3846image
chr15:89832151-89832810:-LGGCCT007093EER2.4668e-090.2568image
ENSG00000157823.15,AP3S2LGGCCT007093EAG3.1424e-080.2388image
chr15:89832151-89832810:-LIHCAZD.2281EER5.1202e-03-0.1903image
ENSG00000157823.15,AP3S2LIHCDasatinibEAG7.7399e-030.1824image
chr15:89832151-89832810:-LUADAKT.inhibitor.VIIIEER5.0116e-05-0.2046image
ENSG00000157823.15,AP3S2LUADGDC0941EAG5.9693e-05-0.2010image
chr15:89832151-89832810:-LUSCGemcitabineEER7.2691e-040.1756image
ENSG00000157823.15,AP3S2LUSCGemcitabineEAG2.6668e-040.1875image
chr15:89832151-89832810:-MESOBI.2536EER7.9351e-03-0.3127image
ENSG00000157823.15,AP3S2MESOCCT007093EAG5.9517e-030.3211image
chr15:89832151-89832810:-OVBMS.536924EER5.6083e-06-0.2662image
chr15:89873304-89874797:-OVAZD6244EER1.8986e-02-0.3564image
ENSG00000157823.15,AP3S2OVBMS.536924EAG1.6854e-05-0.2523image
chr15:89832151-89832810:-PAADBIRB.0796EER1.1921e-02-0.2128image
ENSG00000157823.15,AP3S2PAADBIRB.0796EAG4.5859e-03-0.2383image
ENSG00000157823.15,AP3S2PCPGCCT007093EAG1.4037e-040.3002image
chr15:89832151-89832810:-PCPGBMS.536924EER6.1508e-05-0.3201image
ENSG00000157823.15,AP3S2PRADCEP.701EAG1.5027e-11-0.3084image
chr15:89832151-89832810:-PRADCEP.701EER6.1961e-10-0.2850image
chr15:89832151-89832810:-READBosutinibEER1.5128e-030.3351image
ENSG00000157823.15,AP3S2READBMS.754807EAG1.7520e-03-0.3254image
ENSG00000157823.15,AP3S2SARCCCT018159EAG2.2403e-030.2079image
chr15:89832151-89832810:-SARCAZD7762EER9.1306e-05-0.2661image
ENSG00000157823.15,AP3S2SKCMCHIR.99021EAG1.1991e-040.1866image
chr15:89832151-89832810:-SKCMImatinibEER8.7989e-050.1904image
chr15:89832151-89832810:-STADMethotrexateEER1.5603e-04-0.1996image
chr15:89859392-89860018:-STADEmbelinEER6.5351e-03-0.3055image
ENSG00000157823.15,AP3S2STADMethotrexateEAG1.0168e-04-0.2045image
chr15:89856279-89858284:-STADKU.55933EER5.0957e-030.4105image
chr15:89832151-89832810:-TGCTGefitinibEER2.6941e-030.3462image
ENSG00000157823.15,AP3S2TGCTGefitinibEAG6.1685e-040.3792image
ENSG00000157823.15,AP3S2THCAAKT.inhibitor.VIIIEAG2.1356e-080.2501image
chr15:89832151-89832810:-THCABMS.536924EER8.6626e-14-0.3307image
ENSG00000157823.15,AP3S2THYMGDC.0449EAG2.0534e-06-0.4696image
chr15:89832151-89832810:-THYMGDC.0449EER1.1295e-09-0.5824image
ENSG00000157823.15,AP3S2UCECIPA.3EAG3.7033e-030.2849image
chr15:89832151-89832810:-UCECBAY.61.3606EER9.7314e-030.2697image
chr15:89832151-89832810:-UCSBMS.708163EER2.4017e-030.5105image
ENSG00000157823.15,AP3S2UCSBMS.708163EAG1.8062e-020.3975image
chr15:89832151-89832810:-UVMMidostaurinEER1.0207e-04-0.4363image
ENSG00000157823.15,AP3S2UVMMidostaurinEAG2.7031e-05-0.4644image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType