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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: NBR2 (ImmuneEditome ID:10230)

1. Gene summary of enriched editing regions for NBR2

check button Gene summary
Gene informationGene symbol

NBR2

Gene ID

10230

GeneSynonymsNCRNA00192
GeneCytomap

17q21.31

GeneTypencRNA
GeneDescriptionNeighbor of BRCA1 gene 2 protein|Next to BRCA1 gene 2 protein|neighbor of BRCA1 gene 2 (non-protein coding)
GeneModificationdate20230329
UniprotID.
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr17:43131798-43131998:+ENST00000356906.6ENSG00000198496.9NBR2ncRNA_intronicAluSz6chr17:43131798-43131998:+.alignment
chr17:43131798-43131998:+ENST00000460115.4ENSG00000198496.9NBR2ncRNA_intronicAluSz6chr17:43131798-43131998:+.alignment
chr17:43131798-43131998:+ENST00000467245.4ENSG00000198496.9NBR2ncRNA_intronicAluSz6chr17:43131798-43131998:+.alignment
chr17:43132844-43133905:+ENST00000467245.4ENSG00000198496.9NBR2ncRNA_exonicAluY,MER5A,MIR,AluSzchr17:43132844-43133905:+.alignment
chr17:43137102-43138121:+ENST00000356906.6ENSG00000198496.9NBR2ncRNA_intronicL1PA5,AluSz,AluSq2chr17:43137102-43138121:+.alignment
chr17:43137102-43138121:+ENST00000460115.4ENSG00000198496.9NBR2ncRNA_intronicL1PA5,AluSz,AluSq2chr17:43137102-43138121:+.alignment
chr17:43137102-43138121:+ENST00000467245.4ENSG00000198496.9NBR2ncRNA_intronicL1PA5,AluSz,AluSq2chr17:43137102-43138121:+.alignment
chr17:43139363-43139887:+ENST00000356906.6ENSG00000198496.9NBR2ncRNA_exonicL1PREC2,AluSg4chr17:43139363-43139887:+.alignment
chr17:43139363-43139887:+ENST00000460115.4ENSG00000198496.9NBR2ncRNA_exonicL1PREC2,AluSg4chr17:43139363-43139887:+.alignment
chr17:43141516-43143272:+ENST00000467245.4ENSG00000198496.9NBR2ncRNA_exonic(TG)n,MIRb,AluY,(AT)n,AluSx,(TATT)nchr17:43141516-43143272:+.alignment
chr17:43146340-43152964:+ENST00000467245.4ENSG00000198496.9NBR2ncRNA_intronicA-rich,(AAAT)n,MIR3,AluY,AluSp,LTR88b,AluSx1,L2c,LTR7C,MIRb,AluSx3,AluSz6,AluJr,OldhAT1,L2,AluJb,MER81,AluSzchr17:43146340-43152964:+.alignment


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2. Tumor-specific enriched editing regions for NBR2


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for NBR2


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for NBR2


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for NBR2


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr17:43146340-43152964:+BLCAEERDendritic_cells_activated3.1618e-02-0.1674image
ENSG00000198496.9,NBR2BLCAEAGMacrophages_M14.1926e-030.2079image
chr17:43139363-43139887:+BRCAEERMacrophages_M24.7232e-02-0.2380image
chr17:43146340-43152964:+BRCAEERT_cells_CD81.8562e-02-0.1826image
ENSG00000198496.9,NBR2BRCAEAGT_cells_regulatory_(Tregs)5.3960e-03-0.1724image
chr17:43146340-43152964:+CESCEERDendritic_cells_resting1.6100e-02-0.2635image
ENSG00000198496.9,NBR2CESCEAGDendritic_cells_resting7.0719e-03-0.2678image
ENSG00000198496.9,NBR2CHOLEAGNK_cells_resting4.9978e-020.4044image
ENSG00000198496.9,NBR2COADEAGDendritic_cells_activated2.2778e-040.4775image
chr17:43146340-43152964:+ESCAEERMast_cells_resting2.4164e-020.2265image
ENSG00000198496.9,NBR2ESCAEAGT_cells_regulatory_(Tregs)2.5806e-02-0.1933image
chr17:43139363-43139887:+GBMEEREosinophils3.2393e-020.4472image
ENSG00000198496.9,NBR2GBMEAGT_cells_CD4_memory_resting1.5208e-030.4248image
ENSG00000198496.9,NBR2HNSCEAGT_cells_CD4_memory_resting9.7408e-060.5256image
chr17:43146340-43152964:+KIRPEERT_cells_regulatory_(Tregs)3.0166e-02-0.2169image
ENSG00000198496.9,NBR2KIRPEAGT_cells_regulatory_(Tregs)4.2871e-02-0.1800image
chr17:43146340-43152964:+LAMLEERMast_cells_activated1.3604e-02-0.3309image
ENSG00000198496.9,NBR2LAMLEAGT_cells_follicular_helper1.0309e-020.2769image
chr17:43146340-43152964:+LGGEERT_cells_CD4_naive2.3452e-020.2361image
ENSG00000198496.9,NBR2LGGEAGT_cells_follicular_helper2.1816e-030.2484image
ENSG00000198496.9,NBR2LUADEAGPlasma_cells3.6351e-02-0.1557image
ENSG00000198496.9,NBR2LUSCEAGB_cells_naive2.3884e-020.1882image
ENSG00000198496.9,NBR2PCPGEAGMacrophages_M02.1915e-020.4970image
ENSG00000198496.9,NBR2PRADEAGNeutrophils2.7709e-020.2774image
ENSG00000198496.9,NBR2SARCEAGMast_cells_resting3.0141e-020.3476image
chr17:43132844-43133905:+STADEERNK_cells_activated1.6692e-020.2517image
chr17:43137102-43138121:+STADEERT_cells_CD82.4211e-030.5898image
chr17:43139363-43139887:+STADEERT_cells_CD81.7598e-020.2830image
chr17:43141516-43143272:+STADEERMacrophages_M02.1567e-02-0.2987image
ENSG00000198496.9,NBR2STADEAGEosinophils4.3198e-02-0.1293image
ENSG00000198496.9,NBR2TGCTEAGNK_cells_activated1.3524e-020.4388image
ENSG00000198496.9,NBR2THCAEAGT_cells_CD4_memory_activated2.6809e-02-0.1602image
ENSG00000198496.9,NBR2THYMEAGB_cells_naive3.8894e-02-0.2720image
ENSG00000198496.9,NBR2UCECEAGT_cells_follicular_helper4.2177e-02-0.2701image
ENSG00000198496.9,NBR2UCSEAGDendritic_cells_activated3.3424e-020.4771image


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6. Enriched editing regions and immune gene sets for NBR2


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000198496.9,NBR2BLCAGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG6.8188e-060.3215image
chr17:43146340-43152964:+BLCAGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER1.2636e-020.1938image
chr17:43146340-43152964:+BRCAGSVA_HALLMARK_ANDROGEN_RESPONSEEER2.7134e-030.2313image
ENSG00000198496.9,NBR2CESCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG5.5484e-030.2754image
chr17:43146340-43152964:+CESCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER1.1172e-050.4617image
ENSG00000198496.9,NBR2COADGSVA_HALLMARK_PEROXISOMEEAG1.2788e-03-0.4234image
chr17:43146340-43152964:+ESCAGSVA_HALLMARK_MYOGENESISEER1.1318e-020.2536image
ENSG00000198496.9,NBR2GBMGSVA_HALLMARK_ANGIOGENESISEAG1.3172e-02-0.3385image
chr17:43139363-43139887:+GBMGSVA_HALLMARK_APICAL_SURFACEEER4.5215e-02-0.4214image
ENSG00000198496.9,NBR2HNSCGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG3.7811e-040.4341image
ENSG00000198496.9,NBR2KIRPGSVA_HALLMARK_P53_PATHWAYEAG3.0117e-02-0.1925image
chr17:43146340-43152964:+KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEER6.3129e-030.2714image
chr17:43146340-43152964:+LAMLGSVA_HALLMARK_UV_RESPONSE_DNEER4.5875e-020.2704image
ENSG00000198496.9,NBR2LAMLGSVA_HALLMARK_E2F_TARGETSEAG1.1160e-020.2740image
chr17:43146340-43152964:+LGGGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER2.2735e-030.3144image
ENSG00000198496.9,NBR2LGGGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG7.0490e-05-0.3187image
ENSG00000198496.9,NBR2LUADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG4.4088e-020.1498image
ENSG00000198496.9,NBR2LUSCGSVA_HALLMARK_MYC_TARGETS_V2EAG3.1220e-03-0.2447image
ENSG00000198496.9,NBR2OVGSVA_HALLMARK_COAGULATIONEAG1.2563e-030.2654image
chr17:43146340-43152964:+OVGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER1.7747e-030.3166image
chr17:43139363-43139887:+OVGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER3.1641e-020.3321image
ENSG00000198496.9,NBR2SARCGSVA_HALLMARK_MYC_TARGETS_V1EAG5.8968e-03-0.4330image
chr17:43137102-43138121:+STADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER4.9347e-020.4054image
chr17:43141516-43143272:+STADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER3.7011e-020.2722image
chr17:43146340-43152964:+STADGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER4.6905e-020.1509image
ENSG00000198496.9,NBR2STADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG7.1638e-030.1714image
ENSG00000198496.9,NBR2TGCTGSVA_HALLMARK_GLYCOLYSISEAG1.3871e-020.4374image
chr17:43146340-43152964:+THCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER8.5985e-040.2676image
ENSG00000198496.9,NBR2THCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG8.4975e-060.3159image
ENSG00000198496.9,NBR2THYMGSVA_HALLMARK_UV_RESPONSE_DNEAG3.5373e-030.3770image
ENSG00000198496.9,NBR2UCECGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.8321e-030.4039image
ENSG00000198496.9,NBR2UCSGSVA_HALLMARK_G2M_CHECKPOINTEAG4.8046e-030.6039image


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7. Enriched editing regions and drugs for NBR2


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr17:43146340-43152964:+BLCAJW.7.52.1EER1.2510e-040.2942image
ENSG00000198496.9,NBR2BLCAAICAREAG6.3207e-05-0.2875image
chr17:43146340-43152964:+BRCABMS.536924EER8.0167e-040.2585image
ENSG00000198496.9,NBR2BRCAGSK.650394EAG4.8337e-020.1228image
chr17:43146340-43152964:+CESCBryostatin.1EER1.9373e-030.3354image
ENSG00000198496.9,NBR2CESCAMG.706EAG1.4067e-020.2449image
ENSG00000198496.9,NBR2COADGSK.650394EAG1.6056e-040.4874image
ENSG00000198496.9,NBR2ESCADMOGEAG3.6853e-05-0.3497image
chr17:43146340-43152964:+ESCACyclopamineEER6.8425e-05-0.3892image
ENSG00000198496.9,NBR2HNSCBortezomibEAG3.8141e-040.4339image
ENSG00000198496.9,NBR2KIRPGSK269962AEAG6.2973e-040.3005image
chr17:43146340-43152964:+KIRPCGP.60474EER6.4468e-040.3355image
ENSG00000198496.9,NBR2LAMLAZ628EAG5.7401e-030.2972image
chr17:43146340-43152964:+LAMLBryostatin.1EER3.2388e-030.3901image
ENSG00000198496.9,NBR2LGGDasatinibEAG3.5762e-050.3307image
chr17:43146340-43152964:+LGGA.770041EER3.8278e-040.3626image
chr17:43146340-43152964:+LUADA.770041EER3.1766e-030.2459image
ENSG00000198496.9,NBR2LUADA.770041EAG1.3110e-020.1841image
ENSG00000198496.9,NBR2OVErlotinibEAG2.4438e-04-0.3002image
chr17:43146340-43152964:+OVEpothilone.BEER8.0410e-03-0.2704image
chr17:43139363-43139887:+OVCCT007093EER1.9788e-020.3584image
ENSG00000198496.9,NBR2PAADBIBW2992EAG3.8747e-020.2770image
ENSG00000198496.9,NBR2PRADAMG.706EAG1.0216e-02-0.3214image
ENSG00000198496.9,NBR2SARCCCT007093EAG1.0488e-02-0.4052image
ENSG00000198496.9,NBR2SKCMAMG.706EAG1.0944e-02-0.2700image
chr17:43132844-43133905:+STADGDC.0449EER3.6908e-02-0.2203image
chr17:43139363-43139887:+STADBMS.509744EER2.2529e-03-0.3593image
chr17:43141516-43143272:+STADCCT018159EER1.4546e-03-0.4052image
chr17:43137102-43138121:+STADAZD.2281EER2.6271e-02-0.4529image
chr17:43146340-43152964:+STADBIRB.0796EER2.6402e-040.2733image
ENSG00000198496.9,NBR2STADBMS.708163EAG2.7577e-03-0.1905image
ENSG00000198496.9,NBR2TGCTMG.132EAG2.8958e-02-0.3925image
chr17:43146340-43152964:+THCACCT007093EER1.4249e-04-0.3037image
ENSG00000198496.9,NBR2THCABexaroteneEAG1.1570e-04-0.2753image
ENSG00000198496.9,NBR2THYMAS601245EAG1.0021e-02-0.3356image
ENSG00000198496.9,NBR2UCECGW.441756EAG2.7871e-050.5247image
ENSG00000198496.9,NBR2UCSBicalutamideEAG1.2884e-020.5454image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType