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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: FAM157C (ImmuneEditome ID:100996541)

1. Gene summary of enriched editing regions for FAM157C

check button Gene summary
Gene informationGene symbol

FAM157C

Gene ID

100996541

GeneSynonyms-
GeneCytomap

16q24.3

GeneTypencRNA
GeneDescriptionfamily with sequence similarity 157 member C (non-protein coding)
GeneModificationdate20230329
UniprotID.
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr16:90168413-90170708:+ENST00000568070.1ENSG00000260528.3FAM157CncRNA_intronicNoRepeatchr16:90168413-90170708:+.alignment
chr16:90168413-90170708:+ENST00000570230.1ENSG00000260528.3FAM157CncRNA_intronicNoRepeatchr16:90168413-90170708:+.alignment


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2. Tumor-specific enriched editing regions for FAM157C


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr16:90168413-90170708:+ESCACliEER3.0199e-022.7532e-02-0.3182image
ENSG00000260528.3,FAM157CESCACliEAG2.6767e-022.6213e-02-0.3208image
ENSG00000260528.3,FAM157CKIRPCliEAG1.7989e-022.3135e-020.4278image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr16:90168413-90170708:+LGGEER2.5540e-021.0419e-028.5578e-03image

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3. Enriched editing regions and immune related genes for FAM157C


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for FAM157C


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr16:90168413-90170708:+
ESCAEERA5ENSG00000164733.16chr811842523:11842867:11844468:11844657:11843179:118446570.19631.5675e-031.4478e-090.5691imageNFUS;U2AF2CTSBDendritic_cells_restingGSVA_HALLMARK_ANDROGEN_RESPONSE
ENSG00000260528.3,FAM157C
ESCAEAGA5ENSG00000164733.16chr811842523:11842867:11844468:11844657:11843179:118446570.19631.7799e-032.2328e-090.5637imageNADAR;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX3X;DGCR8;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28B;LSM11;NONO;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM27;SAFB2;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;XRN2;YTHDC1;ZNF184CTSBDendritic_cells_restingGSVA_HALLMARK_ANDROGEN_RESPONSE
ENSG00000260528.3,FAM157C
ESCAEAGIRENSG00000164733.16chr811842523:11842867:11844468:11845222-0.19229.3850e-032.8001e-08-0.4542imageNADAR;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX3X;DGCR8;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28B;LSM11;NONO;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM27;SAFB2;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;XRN2;YTHDC1;ZNF184CTSBDendritic_cells_restingGSVA_HALLMARK_ANDROGEN_RESPONSE
chr16:90168413-90170708:+
ESCAEERIRENSG00000164733.16chr811842523:11842867:11844468:11845222-0.19227.9711e-032.1967e-08-0.4572imageNFUS;U2AF2CTSBDendritic_cells_restingGSVA_HALLMARK_ANDROGEN_RESPONSE

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5. Enriched editing regions and immune infiltration for FAM157C


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000260528.3,FAM157CBLCAEAGT_cells_gamma_delta6.4182e-070.4233image
chr16:90168413-90170708:+BRCAEERDendritic_cells_resting1.5463e-02-0.1524image
ENSG00000260528.3,FAM157CBRCAEAGDendritic_cells_resting1.6883e-02-0.1464image
ENSG00000260528.3,FAM157CCOADEAGDendritic_cells_activated2.5320e-020.3625image
chr16:90168413-90170708:+ESCAEERT_cells_follicular_helper1.6834e-02-0.2047image
ENSG00000260528.3,FAM157CESCAEAGT_cells_follicular_helper1.8871e-02-0.2011image
chr16:90168413-90170708:+HNSCEERB_cells_memory7.2852e-060.4421image
ENSG00000260528.3,FAM157CHNSCEAGB_cells_memory9.7663e-060.4323image
chr16:90168413-90170708:+KIRCEERB_cells_naive2.8308e-020.3762image
ENSG00000260528.3,FAM157CKIRCEAGB_cells_naive3.0779e-020.3710image
ENSG00000260528.3,FAM157CKIRPEAGT_cells_follicular_helper1.8354e-030.4566image
chr16:90168413-90170708:+LAMLEERT_cells_gamma_delta3.4806e-040.3811image
ENSG00000260528.3,FAM157CLAMLEAGT_cells_gamma_delta4.8404e-040.3704image
chr16:90168413-90170708:+LIHCEERMacrophages_M01.9235e-02-0.2680image
ENSG00000260528.3,FAM157CLIHCEAGMacrophages_M02.4146e-02-0.2489image
chr16:90168413-90170708:+LUADEERT_cells_CD83.6560e-040.2672image
ENSG00000260528.3,FAM157CLUADEAGT_cells_CD81.7004e-030.2336image
ENSG00000260528.3,FAM157CLUSCEAGNeutrophils3.0776e-02-0.1437image
chr16:90168413-90170708:+OVEERB_cells_memory8.0661e-030.2514image
ENSG00000260528.3,FAM157COVEAGB_cells_memory1.4516e-020.2325image
ENSG00000260528.3,FAM157CPAADEAGMast_cells_resting8.4370e-030.3550image
ENSG00000260528.3,FAM157CPCPGEAGNeutrophils7.9471e-050.6025image
chr16:90168413-90170708:+PRADEERDendritic_cells_activated4.2371e-020.1905image
ENSG00000260528.3,FAM157CPRADEAGDendritic_cells_activated2.6310e-020.2045image
ENSG00000260528.3,FAM157CSARCEAGNK_cells_activated1.9778e-030.4691image
ENSG00000260528.3,FAM157CSKCMEAGDendritic_cells_resting4.6309e-020.2050image
chr16:90168413-90170708:+STADEERT_cells_follicular_helper2.9923e-020.1528image
chr16:90168413-90170708:+TGCTEERMonocytes4.4503e-020.2078image
ENSG00000260528.3,FAM157CTHCAEAGMonocytes3.8267e-020.1760image
chr16:90168413-90170708:+UCECEERDendritic_cells_activated8.9286e-030.3294image
ENSG00000260528.3,FAM157CUCECEAGDendritic_cells_activated6.5941e-030.3389image


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6. Enriched editing regions and immune gene sets for FAM157C


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000260528.3,FAM157CBLCAGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG2.0292e-02-0.2050image
ENSG00000260528.3,FAM157CBRCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG4.8133e-02-0.1213image
ENSG00000260528.3,FAM157CCOADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG7.1450e-040.5250image
ENSG00000260528.3,FAM157CESCAGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG5.0872e-030.2389image
chr16:90168413-90170708:+ESCAGSVA_HALLMARK_TGF_BETA_SIGNALINGEER4.9951e-030.2394image
ENSG00000260528.3,FAM157CGBMGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.4895e-020.3824image
chr16:90168413-90170708:+GBMGSVA_HALLMARK_DNA_REPAIREER2.4113e-020.3702image
chr16:90168413-90170708:+HNSCGSVA_HALLMARK_FATTY_ACID_METABOLISMEER4.9517e-02-0.2021image
chr16:90168413-90170708:+KIRCGSVA_HALLMARK_APICAL_SURFACEEER3.5590e-020.3617image
ENSG00000260528.3,FAM157CKIRCGSVA_HALLMARK_APICAL_SURFACEEAG2.4350e-020.3855image
ENSG00000260528.3,FAM157CKIRPGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG1.2926e-020.3719image
ENSG00000260528.3,FAM157CLAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.4144e-05-0.4519image
chr16:90168413-90170708:+LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.9868e-04-0.3952image
ENSG00000260528.3,FAM157CLGGGSVA_HALLMARK_HYPOXIAEAG6.1489e-03-0.2313image
ENSG00000260528.3,FAM157CLIHCGSVA_HALLMARK_HEME_METABOLISMEAG5.8845e-030.3017image
chr16:90168413-90170708:+LIHCGSVA_HALLMARK_PANCREAS_BETA_CELLSEER8.8169e-030.2985image
ENSG00000260528.3,FAM157CLUSCGSVA_HALLMARK_PEROXISOMEEAG4.5082e-020.1334image
chr16:90168413-90170708:+LUSCGSVA_HALLMARK_PEROXISOMEEER2.5940e-020.1498image
ENSG00000260528.3,FAM157COVGSVA_HALLMARK_MYC_TARGETS_V1EAG1.3667e-030.3016image
chr16:90168413-90170708:+OVGSVA_HALLMARK_MYC_TARGETS_V1EER6.9882e-040.3184image
chr16:90168413-90170708:+PRADGSVA_HALLMARK_ANGIOGENESISEER1.6062e-020.2251image
ENSG00000260528.3,FAM157CPRADGSVA_HALLMARK_ANGIOGENESISEAG2.5747e-020.2053image
ENSG00000260528.3,FAM157CSARCGSVA_HALLMARK_APICAL_JUNCTIONEAG5.1973e-030.4284image
chr16:90168413-90170708:+STADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.4702e-020.1580image
ENSG00000260528.3,FAM157CSTADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.8356e-020.1535image
ENSG00000260528.3,FAM157CTGCTGSVA_HALLMARK_APICAL_SURFACEEAG2.8193e-020.2252image
chr16:90168413-90170708:+THCAGSVA_HALLMARK_GLYCOLYSISEER1.3556e-020.2128image


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7. Enriched editing regions and drugs for FAM157C


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000260528.3,FAM157CBLCAAICAREAG1.9384e-030.2715image
chr16:90168413-90170708:+BLCAAZD6482EER4.7776e-030.2528image
chr16:90168413-90170708:+BRCAFTI.277EER6.5007e-03-0.1710image
ENSG00000260528.3,FAM157CBRCAFTI.277EAG2.0208e-03-0.1885image
chr16:90168413-90170708:+CESCBosutinibEER1.2812e-020.2212image
ENSG00000260528.3,FAM157CCESCBosutinibEAG7.2172e-030.2373image
ENSG00000260528.3,FAM157CCOADCGP.60474EAG2.5458e-020.3622image
chr16:90168413-90170708:+ESCAJNK.9LEER3.3687e-030.2497image
ENSG00000260528.3,FAM157CESCAJNK.9LEAG3.4373e-030.2492image
ENSG00000260528.3,FAM157CGBMGDC0941EAG4.2694e-020.3221image
chr16:90168413-90170708:+KIRCAZD6244EER1.2592e-020.4234image
ENSG00000260528.3,FAM157CKIRCAZD6244EAG1.6261e-020.4092image
ENSG00000260528.3,FAM157CKIRPCGP.082996EAG4.0595e-03-0.4247image
ENSG00000260528.3,FAM157CLAMLGefitinibEAG3.4450e-03-0.3138image
chr16:90168413-90170708:+LAMLGefitinibEER5.7893e-03-0.2987image
ENSG00000260528.3,FAM157CLGGEtoposideEAG7.6917e-03-0.2252image
chr16:90168413-90170708:+LIHCAICAREER2.2283e-02-0.2619image
chr16:90168413-90170708:+LUADKIN001.135EER3.8386e-020.1571image
ENSG00000260528.3,FAM157CLUADCGP.60474EAG4.7522e-020.1488image
ENSG00000260528.3,FAM157CLUSCBortezomibEAG8.6251e-03-0.1743image
chr16:90168413-90170708:+LUSCBortezomibEER3.5469e-03-0.1954image
ENSG00000260528.3,FAM157COVCCT007093EAG2.0710e-040.3467image
chr16:90168413-90170708:+OVCCT007093EER4.8964e-050.3771image
ENSG00000260528.3,FAM157CPAADAICAREAG5.9420e-03-0.3697image
ENSG00000260528.3,FAM157CPCPGBIRB.0796EAG4.1568e-02-0.3367image
chr16:90168413-90170708:+PRADAMG.706EER2.1317e-03-0.2848image
ENSG00000260528.3,FAM157CPRADMetforminEAG5.1572e-030.2559image
ENSG00000260528.3,FAM157CSARCBMS.754807EAG4.3846e-03-0.4359image
ENSG00000260528.3,FAM157CSKCMBI.D1870EAG1.6028e-020.2465image
chr16:90168413-90170708:+SKCMCisplatinEER7.8920e-03-0.2799image
chr16:90168413-90170708:+STADAZ628EER2.8081e-04-0.2530image
ENSG00000260528.3,FAM157CSTADAZ628EAG2.6932e-04-0.2525image
chr16:90168413-90170708:+TGCTElesclomolEER3.1841e-020.2216image
chr16:90168413-90170708:+THCAAG.014699EER2.8939e-020.1888image
ENSG00000260528.3,FAM157CTHYMJNK.Inhibitor.VIIIEAG3.1899e-020.3634image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType